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RETREAT MISSION STATEMENT
The Verna and Marrs McLean Department of Biochemistry and Molecular Biology
and The Department of Pharmacology and Chemical Biology
We take pride in the enormous breadth of biomedical research carried out within our two departments. This broad scope provides unique opportunities for cross-field education and intra- and inter-departmental collaboration. It is in the spirit of this cooperative venture that we hold the annual retreat, the goals of which are threefold: 1. To inform the departments as a whole about the state of research in the specific fields represented
within the departments. 2. To provide a congenial atmosphere where department members can present their research in a
manner conducive to collaboration. 3. To allow scientists at all levels the opportunity to hone their professional skills in an informal setting.
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BMB-PHARM RESEARCH CONFERENCE
OCTOBER 11 & 12, 2018
SCHEDULE OF EVENTS
Thursday, October 11th 8:00 a.m. – 8:45 a.m. Continental Breakfast Davidson South
8:00 a.m. – 8:45 a.m. Registration Davidson Annex
8:50 a.m. Opening Remarks Davidson North
9:00 a.m. – 10:00 a.m. SESSION 1 Davidson North
10:00 a.m. – 10:15 a.m. Departmental Photo Davidson Staircase
10:15 a.m. – 11:00 a.m. Poster Ranking Davidson Annex
11:00 a.m. – 12:00 p.m. SESSION 2 Davidson North
12:00 p.m. – 2:00 p.m. Lunch The Strand
2:00 p.m. – 3:00 p.m. SESSION 3 Davidson North
3:00 p.m. – 4:00 p.m. POSTER SESSION I (Odd) Davidson Annex
4:00 p.m. – 5:30 p.m. Free time
5:30 p.m. – 7:00 p.m. Cocktails & Costumes Davidson Annex
7:00 p.m. – 8:30 p.m. Dinner Davidson South
8:30 p.m. – 11:00 p.m. Dance Davidson South
Friday, October 12th
8:30 a.m. – 9:30 a.m. Breakfast Buffet Davidson South
9:30 a.m. – 10:30 a.m. SESSION 4 Davidson North
10:30 a.m. – 10:45 a.m. Break
10:45 a.m. – 11:45 a.m. POSTER SESSION II (Even) Davidson Annex
11:45 a.m. – 12:45 p.m. Lunch Davidson South
12:45 p.m. – 1:45 p.m. SESSION 5 Davidson North
1:45 p.m. – 2:00 p.m. Break
2:00 p.m. – 3:00 p.m. SESSION 6 Davidson North
3:00 p.m. – 3:30 p.m. Awards and Announcements
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1) Tacon’ Madre Food Truck (Latin American) 2100 Strand Hendley Park (no rating, 5 min walk) 2) Stranded Corner (Seafood) 2100 Strand St. (no rating, 5 min walk) 3) Old Strand Emporium (Deli) 2112 Strand St. (4.5 out of 5 stars, 4 min walk) 4) Stuttgarden Tavern (American, German) 2110 Strand St. (4 out of 5 stars, 5 min walk) 5) Starbucks (Café, American) 102 22nd St. (4.5 out of 5 stars, 4 min walk) 6) Willie G’s Seafood and Steaks (Seafood, American) 2100 Harborside Dr. (4 out of 5 stars, 7 min walk) 7) Fisherman’s Wharf (American, Seafood, Deli) 2200 Harborside Dr. (4 out of 5 stars, 5 min walk) 8) Olympia Grill at Pier 21 (American, Seafood, Mediterranean, Greek, International) 100 21st Street Harbor House Hotel (4.5 out of 5 stars, 7 min walk)
9) Hubcap Grill and Cocktail Bar (American) 2021 Strand St. (4 out of 5 stars, 5 min walk)
10) Shrimp and Stuff Downtown (American, Seafood) 2021 Strand St. (4 out of 5 stars, 5 min walk)
11) Jimmy Johns (American) 102 22nd Street (4 out of 5 stars, 4 min walk) 12) Mama Teresa’s Flying Pizza (Italian) 416 21st St. (4.5 out of 5 stars, 6 min walk) 13) HuliHuli Hut (American) 312 19th St. and Mechanic (4 out of 5 stars, 9 min walk) 14) El Pinoy (Filipino, Asian) 101 21st St., Ste. 4 (3.5 out of 5 stars, 6 min walk) 15) Yaga’s Tropical Café (American) 2314 Strand St. (4 out of 5 stars, 3 min walk) 16) Trattoria La Vigna (Italian) 412 20th St. (4.5 out of 5 stars, 7 min walk) 17) The Tremont Café (American, Café) 2300 Ship Mechanic Row St. (4 out of 5 stars, 1 min walk) 18) Sky Bar Steak and Seafood (Japanese, Sushi,
American) 2105 Post Office St. (4 out of 5 stars, 7 min walk)
19) La Mixteca Mexican Restaurant (Mexican) 1818 Mechanic St. (4.5 out of 5 stars, 10 min walk) 20) Mediterranean Chef (Mediterranean, Greek, Middle Eastern) 2402 Strand St. (4 out of 5 stars, 2 min walk)
Restaurants Near the Strand
***ALL WALK TIMES LISTED ARE ONE-WAY***
Lunch on the Strand Thursday, October 11, 2018
12:00 p.m.– 2:00 p.m.
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BMB-PHARM RESEARCH CONFERENCE
OCTOBER 11 & 12, 2018
THURSDAY, OCTOBER 11 8:00 am – 8:45 am CONTINENTAL BREAKFAST Davidson South
8:00 am – 8:45 am Registration Davidson Annex
8:50 am Opening Remarks Davidson North
SESSION 1 Session Moderator: Jin Wang, Ph.D. [F] Davidson North
9:00 am – 9:20 am Ming Zhou, Ph.D. [F] Elevators in Cell Membrane: Transporters in Motion
9:20 am – 9:40 am Josephine Ferreon, Ph.D. [F] Changing Phases of Intrinsically Disor-
dered Proteins
9:40 am – 10:00 am Rui Chen, Ph.D. [F] Degeneration and Survival of Photoreceptor Cells in the
Spata7 Mutant Retina
10:00 am – 10:15 am Departmental Photo Davidson Staircase
10:15 am – 11:00 am Poster Ranking Davidson Annex
SESSION 2 Session Moderator: Diana Cox [GS] (Cooper Lab) Davidson North
11:00 am – 11:20 am Wanderson Rezende [GS] (D Young Lab) Exploring the Potential of Bi-
functional Degraders as Chemical Probes to Study the HIV Replication Cycle
11:20 am – 11:40 am Tao Wang [PD] (N Young Lab) Histone Acetylation Increases Within
Minutes after Histone Deacetylase Inhibitor Treatment
11:40 am – 12:00 pm Alex Saltzman [GS] (Malovannaya Lab) Hypothesis Generation from the
Integration of Multiproteomic Data and a posteriori Knowledge to Generate
Hypothesis from CD4+T Cell & HIV Activation
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12:00 pm – 2:00 pm Lunch The Strand
SESSION 3 Session Moderator: Thu Vu Phuc Nguyen [GS] (Golding Lab) Davidson North
2:00 pm – 2:20 pm Teng-Kuei Hsu [GS] (Lichtarge Lab) A Calculus of Mutational Landscapes
Reveals Novel Cancer Driver Genes Under Positive Selection
2:20 pm – 2:40 pm Fangrui Wu [F] (Song Lab) Synthesis, SAR and Biological Activity of Thi-
ophene-Containing Inhibitors of Histone Acetyltransferase P300/CBP
2:40 pm – 3:00 pm Ryan Haley [GS] (Z Zhou Lab) The Small GTPase RAB-35 Defines a Novel
Pathway for Apoptotic Cell Clearance in Caenorhabditis Elegans
3:00 pm – 4:00 pm POSTER SESSION 1 (Odd) Davidson Annex
4:00 pm – 5:30 pm Free time
5:30 pm – 7:00 pm Cocktails & Costumes Davidson Annex
7:00 pm – 8:30 pm Dinner Davidson South
8:30 pm – 11:00 pm Dance Davidson South
FRIDAY, OCTOBER 12
8:30 am – 9:30 am BREAKFAST BUFFET Davidson South
SESSION 4 Session Moderator: Kehan Chen [GS] (M Zhou Lab) Davidson North
9:30 am – 9:50 am Cameron Brown [GS] (Palzkill Lab) Molecular Basis for Negative Epistasis
Between Two Naturally Occurring Drug-Resistance Mutations in CTX-M-β lac-
tamases
9:50 am – 10:10 am Mahdi Moosa [PD] (A Ferreon Lab) Deciphering complexities in Sox2-DNA
Interactions Using Single-molecule Spectroscopy
10:10 am – 10:30 am Jing Zhang [GS] (Golding Lab) Measuring Transcription at a Single
Gene Copy Illuminates mRNA Dynamics and Reveals Intracellular Correlations
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10:30 am – 10:45 am Break
10:45 am – 11:45 am POSTER SESSION 2 (Even) Davidson Annex
11:45 am – 12:45 pm Lunch Davidson South
SESSION 5 Session Moderator: Vidya Sethunath [GS] (Schiff Lab) Davidson North
12:45 pm – 1:05 pm Franklin Gu [GS] (Sreekumar Lab) Kynurenine Pathway Enzyme
AADAT Promotes Breast Cancer Progression and Immunosuppression in
Triple-negative Breast Cancer
1:05 pm – 1:25 pm Renae Bertrand [GS] (R Chen Lab) Investigating the Mechanism of
Retinal Degeneration Due to Mutations in CWC27
1:25 pm – 1:45 pm Dorit Donoviel [F] (Donoviel Lab) Exciting Research & Programs at the
Translational Research Institute for Space Health
1:45 pm – 2:00 pm Break
SESSION 6 Session Moderator: Nicolas Young, Ph.D. [F] Davidson North
2:00 pm – 2:20 pm Liya Hu, Ph.D. [F] Glycan Recognition in Gastrointestinal Viral Patho-
gens
2:20 pm – 2:40 pm Koen Venken, Ph.D. [F] The Collateral Analysis of Cellular Signaling
Events Using Multiplex Luciferase Assaying
2:40 pm – 3:00 pm Charles Lin, Ph.D. [F] Targeting Transcriptional Circuitries in Disease
3:00 pm – 3:30 pm AWARDS CEREMONY: Timothy Palzkill, Ph.D. and Ted Wensel, Ph.D.
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THE JOSHI
MEMORIAL PRIZE Dr. Vadusev C. Joshi was born in Gujarat, India. He
received his B.S. degree in pharmacy from Madras
Medical College in 1959, ranking among the top 5% of
students in the state. After earning his M.S.
degree in pharmacy from Andra Pradesh University in
1961, Dr. Joshi began his Ph.D. studies in the
Department of Biochemistry at the Indian Institute of
Science in Bangalore. Under the tutelage of Dr.
T. Ramasarma, he studied ubiquinone and related
compounds, earning his doctorate in biochemistry in
1964. While a postdoctoral fellow at the Indian
Institute of Science, Dr. Joshi was awarded a Ford
Foundation Research Fellowship. In 1966, he was
awarded the prestigious Fulbright Fellowship, which
allowed him to come to the United States to further his
education at Duke University in the Departments of Pediatrics and Biochemistry. There, he
continued his studies of ubiquinone and eventually became interested in fatty acid synthesis. In
1972, Dr. Joshi accepted a position as an assistant professor in the Department of Biochemistry
at Baylor College of Medicine under the leadership of Dr. Salih J. Wakil. While at BCM, he con-
tinued his investigations of fatty acid synthesis. He was promoted to associate professor in
1977 and was honored with a prestigious Research Career Development Award from the Na-
tional Institutes of Health the same year. During his tenure at BCM, Dr. Joshi published numer-
ous papers and was an active member of the Admissions Committee. In 1980, Dr. Joshi spent
a year in the laboratory of Dr. Hargovind Khorana in the Department of Chemistry at the Massa-
chusetts Institute of Technology. After returning to BCM in late 1981, he continued his research
in fatty acid synthesis and gene regulation until his untimely death in 1982. Dr. Joshi not only
was a committed and hardworking scientist; he was an active member of the Indian community
and a strong patron of the arts. Most importantly, Dr. Joshi was a devoted husband to his wife
Yogini and a doting father to his three daughters, Harshini, Yamini, and Meena.
As a tribute to Dr. Joshi for his dedication to excellence in education and research, his family,
friends, and colleagues established a memorial fund in his honor in 1986. The Joshi
Memorial Prize is granted to students and postdoctoral trainees within the Department of
Biochemistry in recognition of their outstanding oral and poster presentations at the annual re-
search conference.
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JUDGING CRITERIA Oral Presentations
I PRESENTATION (30%)
Organization of talk, clarity of presentation
Quality of slides, legibility & clarity of labeling, color & contrast
Engaging, entertaining, style
Time management
II RESEARCH (40%)
Significance for biomedical or basic science
Quality of data, difficulty of experiments
Interpretations justified, conclusions sound
Innovative approach or techniques
Clear acknowledgment of work by others
III INTERACTION (30%)
Did the talk stimulate questions
Ability to respond to questions
Display knowledge outside prepared presentation
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JUDGING CRITERIA Poster Presentations
I POSTER (30%)
Organization of poster, clear flow, aesthetics
Abstract, hypothesis or question, conclusions, acknowledgments
Legible figures, clearly & concisely labeled
II RESEARCH (40%)
Significance for biomedical or basic science
Quality of data, difficulty of experiments
Interpretations justified, conclusions sound
Innovate approach or techniques
How much work is done by the presenter
III INTERACTION (30%)
Was the poster presented clearly
Ability to respond to questions
Knowledge outside prepared presentation
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POSTER RANKING CRITERIA
I POSTER (40%)
Organization of poster, clear flow, aesthetics
Abstract, hypothesis or questions, conclusions, acknowledgments
Legible figures, clearly & concisely labeled
II RESEARCH (60%)
Significance for biomedical or basic science
Quality of data, difficulty of experiments
Interpretations justified, conclusions sound
Innovative approach or techniques
How much work is done by the presenter
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POSTER RANKING SHEETS THURSDAY, 10:15 A.M. - 11:00 A.M.
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POSTER FEEDBACK SHEET THURSDAY, 3:00 P.M. - 4:00 P.M.
13
POSTER FEEDBACK SHEETS FRIDAY, 10:45 A.M. - 11:45 A.M.
SPECIAL THANKS
Biochemistry and Molecular Biology Chair:
Ted Wensel, Ph.D.
Pharmacology and Chemical Biology Chair:
Tim Palzkill, Ph.D.
Retreat Organizing Committee:
B.V.V. Prasad, Ph.D.
Akhila Balasubramanian
Renae Bertrand
Imani Bijou
David Boragine
Elizabeth Bowling
Shelton Boyd
Shawn Briley
Christy Charles
Kehan Chen
Diana Cox
Adam Fluty
Secondra Holmes
Heyuan Li
Andrew McCullough
Quynh Nguyen
Thu Vu Phuc Nguyen
Omar Peña Ramos
Ruth Reeves
Liying Qin
Alexander Saltzman
Victoria Soeung
Vidyalakshmi Sethunath
Doris Taylor
Kim Tran
Lie Wang
Photography:
Omar Peña Ramos
Andrew McCullough
Registration:
Ruth Reeves
1st-year graduate students
Retreat Website:
Steve Ludtke
Adam Fluty
Alex Saltzman
Poster Judging Committee
Oral Presentation Judging Committee