Moringa Background Nutrition Heath

Polyphenols Isothiocyanates

Moringa Phytochemistry, Processing, and Bioactivity

Moringa Potential – Sustainable Research & Ventures for Global Health, Agriculture, and Climate

Credit: Flickr/US Army Africa

Patented Food Grade Extraction Process

Harnesses Nutrients & Bioactive

Anti-inflammatory MICs Stability

*Reported 75% degradation of

sulforaphane (SF) after 6 days at 37°C.11

References

1. Gopalan, C., Sastri, B. V. R., Balasubramanian, S. C., & Nutrition, N. I. o. (1989). Nutritive Value of Indian

Foods: National Institute of Nutrition, Indian Council of Medical Research.

2. Fahey, J. W. (2005). Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic,

and Prophylactic Properties. Trees for Life Journal 1, 5.

3. Anwar, F., Latif, S., Ashraf, M., & Gilani, A. H. (2007). Moringa oleifera: a food plant with multiple

medicinal uses. Phytotherapy Research, 21(1), 17-25.

4. Mbikay, M. (2012). Therapeutic potential of Moringa oleifera leaves in chronic hyperglycemia and

dyslipidemia: a review. Frontiers in Pharmacology, 3, 1-12.

5. Bennett, R. N., Mellon, F. A., Foidl, N., Pratt, J. H., Dupont, M. S., Perkins, L., & Kroon, P. A. (2003).

Profiling Glucosinolates and Phenolics in Vegetative and Reproductive Tissues of the Multi-Purpose Trees

Moringa oleifera L. (Horseradish Tree) and Moringa stenopetala L. Journal of Agricultural and Food

Chemistry, 51(12), 3546-3553.

6. Traka, M., & Mithen, R. (2009). Glucosinolates, isothiocyanates and human health. Phytochemistry

Reviews, 8(1), 269-282.

7. Song, L., & Thornalley, P. J. (2007). Effect of storage, processing and cooking on glucosinolate content of

Brassica vegetables. Food & Chemical Toxicology, 45(2), 216-224.

8. Sipahioglu, O., & Barringer, S. A. (2003). Dielectric Properties of Vegetables & Fruits as a Function of

Temperature, Ash, & Moisture Content. Journal of Food Science, 68(1), 234-239.

9. Force, L. E., O’Hare, T. J., Wong, L. S., & Irving, D. E. (2007). Impact of cold storage on glucosinolate

levels in seed-sprouts of broccoli, rocket, white radish and kohl-rabi. Postharvest Biology and Technology,

44(2), 175-178.

10. Pereira, F. M. V., Rosa, E., Fahey, J. W., Stephenson, K. K., Carvalho, R., & Aires, A. (2002). Influence

of Temperature and Ontogeny on the Levels of Glucosinolates in Broccoli (Brassica oleracea Var. italica)

sprouts and their effect on the induction of mammalian phase 2 enzymes. Journal of Agricultural and Food

Chemistry, 50:6239-44.

11. Franklin SJ, Dickinson SE, Karlage KL, Bowden GT, Myrdal PB. 2013. Stability of sulforaphane for

topical formulation. Drug Development and Industrial Pharmacy. 0:1-9.

Carrie Waterman Department of Nutrition, UC Davis cwaterman@ucdavis.edu

Kay Dewey, Peter Havel, Elizabeth Mitcham, UC Davis

Jennifer Orwa, Violet Wanjihia, KEMRI; Ramni Jamnadass, ICRAF- Kenya

Ilya Raskin, Rutgers Univeristy

Acknowledgements:

This project was supported by P50AT002776-01 from the National Center for Complementary and

Alternative Medicine (NCCAM) and the Office of Dietary Supplements (ODS), which funds the

Botanical Research Center and Botanical Research Center Pilot Program Sub award

5P50AT002776-08 S12-50318. CW and DC were also supported by NIH training grant T32:

5T32AT004094-04. PRS was supported by the SENESCYT 2011 Fellowship. We would like to

thank Rodney Perdew from Moringa Farms, CA for supplying high-quality moringa leaves.

Uses

Health

Nutrition

Agriculture

Livestock Feed

Water Purification

Value-added Products

Moringa oleifera is a fast

growing, drought-tolerant

tree, native to the subtropics.

It is an economically &

sustainably valuable

multipurpose plant ideal to

be meet the SDGs.

Agriculture & Animals

Biofertilizer

Plant Growth Promotor

Pest & Nematocide Control

Integrated Crop Management

Protein-rich Animal Fooder

Reduces blood

pressure and

cholesterol levels

Controls blood sugar for

prevention & treatment

of diabetes

Stabilizes body weight

by building muscle &

reducing excess fat

Builds strong bones. Prevents

and treats inflammation and

arthritis in joints

Enhances brain function &

memory, while reducing

anxiety & headaches

Boosts immunity to fight

colds & viruses for faster

illness recovery

Provide essential vitamins

& nutrients for child

growth & development

Increases breastmilk

& nutrition for

infants

Increases energy, stamina,

body function, and improves

sleep

Resilient Moringa: A Crop for Sustainable Nutrition, Health, and Agriculture in Africa

Moringa Isothiocyantes MICs

• Compounds similar to sulforaphane (SF) from broccoli, but with added chemical stability & bioavailabitly

• Demonstrated in vitro:

• Potent anti-inflammatory activity in macrophages (Reduced cytokine expression in vitro)

• Activate detoxification pathways (Nrf2/KEAP1)

• Reduced glucose production in vitro

• Demonstrated in vivo activity

• Moringa concentrate (MC) containing nutrients, polyphenols, and MICs reduced weight gain, cholesterol, insulin resistance, and inflammation diet-induced obese C57 mice.

*Potential to Contribute to 13/17 UN SDGs

•Construction of 5 UC Davis designed chimney solar dryer for faster safer drying of Moringa leaves in Kenya

•Supporting and training small-scale farmers and mothers to eat, grow, and use moringa in Kenya for nutrtion, health, and income generation.

•Exploring genetic variation and growing techniques for improved quality and post harvest processing in collaboration with the African Orphan Crop Consortium (AOCC).

•Experimentation with MC and MICs and as bionematocide and protein supplement in animal feed

•Planning clincal trials for prevention of Type II diabetes in Kenya

Bioactivity