Residue 22

D (Asp)

E (Glu)

Residue 81

I (Ile)

V (Val)

Residue 132

H (His)Y (Try)

Residue 154

E (Glu)

D (Asp)

Residue 160

A (Ala)

V (Val)

Supplementary Figure 1A

Residue 270N

T (Thr)N (Asp) I (Ile)

Residue 270I

T (Thr)

Residue 301T

T (Thr)L (Leu)

Residue 301S

L (Leu)

S (Ser)

Residue 302

N (Asp)G(Gly)

Residue 380,383,386

N (Asp)K (Lys)

T (Thr)

I (Ile)

K (Lys)

R(Arg)

Residue 68

I (Ile)V (Val)

Residue 169

A (Ala)

V (Val)

R (Arg)

K (Lys)

Residue 231 Residue 303

T (Thr)

A (Ala)

Residue 391

R (Arg)

K (Lys)

Supplementary Figure 1B

Residue 140

I (Ile)

T (Thr)

Supplementary Figure 1C