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7/23/2019 Reseptor Adrenergik
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Reseptor Adrenergik
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The adrenergic receptors(or adrenoceptors)are a class of G protein-coupled receptorsthat
are targets of the catecholamines, especially
norepinephrine(noradrenaline) and epinephrine
(adrenaline).
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http://en.wikipedia.org/wiki/G_protein-coupled_receptorhttp://en.wikipedia.org/wiki/Catecholaminehttp://en.wikipedia.org/wiki/Norepinephrinehttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Epinephrinehttp://en.wikipedia.org/wiki/Norepinephrinehttp://en.wikipedia.org/wiki/Catecholaminehttp://en.wikipedia.org/wiki/G_protein-coupled_receptor7/23/2019 Reseptor Adrenergik
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Reseptor adrenergik
Alfa 1 !asoconstrikto "ncreased
peripheralresutance
"ncreased
#lood pressure $idriasis
"ncreasedclosure of
internal
spinchter of
the #ladder
Alfa % "nhi#ition of
&' release "nhi#iton of
insulin
release
eta 1
Takikardi
"ncreasedlipolysis
"nreased
miocard
conractolity
eta% !asodilatasi ecreased
perpheral resist ronchoconstric
tion "ncreased
muuscle * li+er
gluconeogynesi
s "ncreased
release of
glucagon Relaed uterine
smooth muscle
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CLONIDIN
entrally acting selecti+e partail 2 adrenergic
agonist Clinical uses :
Antihypertensive drug by virtue f its ability to decrease
SNS output from the CNS ( 0,20,! mg daily p"o #Anaesthetic ad$uvant in spinal or epidural anesthesia
1 mcgkg
%ive analgesia effect &ithin spinal cord modulate
pain path&ay at dorsal horn such as ma$or site fortransmission and modulation pain ( by mimic'ing
activation pf descending Noradrenergi' path&ay and
inhibiting release of substance #
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/reanesthetic medication ( 0 mcgkg p.o #lunt
refle tachycardi ) a,decrease intraoperati+e
la#ility /-R, decrease plasma cathecolamine
concentartion )
/rolong the effect of RA ( 20-103 mcg )
/rotection against perioperati+e myocardischemia ( 3,% mg p.o or transder,al patch )
iagnosis of pheocromocytomareflect a#ility
clonidin to suppress the endogenous release of
cathecolamine #ut not diffusion of ecess
catecholamine into circulation from a
pheocromocytoma ( 3,4 mg p.o )
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Treatment of opioid and alcohol withdrawl syndr
Treatment shi+ering ( 20 mcg "! )
/erioperati+e myocardial ischemia
5ide effect 6
5edation and erostomia
Re#ound y7ertension 8 hr - 49 hr after last dose
( : 1,% mg daily )
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Muscle Relaxan
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Obat
RenalExcretion
(%
Uncanged!
"iliar#Excretion
(%
Uncanged!
$epaticDegradatio
n (%!
Eliination
Dependent
on Renal&unction
Eliination
Dependent
on $epatic&unction
Eliination $al')ie (in!
&ormal ;idneyfailure
epaticfailure
/ancuroniu
m
83 0-13 13
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