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M Olivia HarrisSenior Environmental Health Scient ist
NCEH/ATSDR Office of [email protected]
Research Translat ion in Act ion:
Building Relat ionships
between
SRP and NCEH/ATSDR Scient ists
Agency for Toxic Substances and Disease RegistryNational Center for Environmental Health
Perspect ive from the joint ly managed
Agency for Toxic Substances and Disease Registry(Superfund hazardous waste sites)
ht tp://www.atsdr.cdc.gov/
&
National Center for Environmental Health(exposures from all sources) ht tp://www.cdc.gov/nceh/
SRP Purpose
Fund mult i-disciplinary research which
Environmental Managers & Risk Assessors(such as ATSDR Scient ists)
Can USEto make decisions
about Superfund & other Hazardous Waste Sites.
To Facilitate Research Translat ion,NIEHS Encourages SRP grantees to form Partnerships with
NCEH/ATSDR ATSDR State Cooperat ive Agreement Partners
Region 4 EPA
SO
We have Prompt Access to SRP Research
SRP Grantees have Feedback on our RESEARCH Needs
Building Relat ionships between NCEH/ATSDR Scient ists & SRP Grantees
WE can’t work with YOU
IF
WE don’t know YOU….(OR know your expert ise)
A Research Translat ion Strategy that Works
Seminar & Networking Opportunity at NCEH/ATSDR
NCEH/ATSDR Scient ists
Get to Know
SRP grantee scient ists
So we learn what Tools & Expert ise SRP has to HELP US
Seminar Audience
NCEH/ATSDRRegion 4 EPA
Emory Medical Toxicology Program traineesCDC (including NIOSH)
Online (LiveMeeting):ATSDR State Cooperat ive Agreement Partners
ATSDR Regional Offices
Low pressure format for NCEH/ATSDR Scient ists
from diverse Environmental Health Disciplines
to Explore Mutual Interests
with SRP Scient ists
One on One Interact ionsMay Catalyze
Faster use of Basic Research Insights in Applied Environmental
Public Health Pract ice
Many desired outcomes are not easily quant ified.
NCEH/ATSDR learns about new developments in basic science
DHAC/ATSDR has used information gained from the seminars & individual meet ings in their Public Health Assessments
SRP grantees learn about NCEH/ATSDR programs, research, and research needs.
Scient ific networking connect ions made for future use
Collaborat ions & cooperat ion are considered
The Zenith of Success
Collaborat ions are Easily Counted Outcomes
But
Should not be the Only Metric for Evaluat ing
this Research Translat ion Act ivity
New Collaborat ions Developed: I
Jim Swenberg, University of North Carolina-Chapel Hill&
Protein Biomarker Lab/NCEH
NCEH chemists analyzed acrylamide and glycidamide hemoglobin adducts as biomarkers of exposure for a case control study on brain tumors.
Jim Swenberg’s lab measured butadiene hemoglobin adducts in the same study. The data are current ly being analyzed.
New Collaborat ions Developed : II
Clem Furlong, University of Washington&
Emergency Response & Air Toxicants Branch/NCEH
Development of Novel Blood Biomarkers to aid in diagnosing human exposure to
Cholinesterase Inhibitors
[bioterrorism agents, organophosphate insect icides, organophosphate ester addit ives to lubricants and
hydraulic fluids]
Potent ial Collaborat ions Incubating Now
Grant proposal ideas being kicked around.
NCEH scient ists were contacted by an epidemiologist from a non-SRP inst itut ion.
“ If we hadn’t met this SRP grantee when he visited, we wouldn’t have thought of including him when brainstorming about study design.”
Challenges
Lack Funding to follow through on all
Ideas for Potent ial Collaborat ions between SRP grantees & NCEH/ATSDR
NCEH/ATSDR scient ists ask: Will SRP
Fund some collaborat ions?Provide some seed money to start pilot projects?
Thank YOU!!!SRP & SRP grantees
for funding &
part icipat ing in this Research Translat ion Act ivity!
2007- 2010 SRP Part icipants
University of North Carolina-Chapel Hill
Frederic K. PfaenderBioavailability as a Factor in Pollutant Exposure
Leena A. Nylander-FrenchPharmacokinet ics of the Interact ion between Inhaled &
Dermal Absorpt ion of Naphthalene, an Environmental PAH
James A. SwenbergBiomarkers of Exposure and Effect: Implicat ions for Risk
Assessment
Duke University & University of Colorado-BoulderKarl G. Linden
From PAHs to Organophosphates: Photolyt ic Fate in Engineered & Natural Systems
University of California-BerkeleyJames R. Hunt
Dense Brines as Sources of Groundwater Contaminat ion by Perchlorate & Chromate
Columbia UniversityTom K. Hei
The How and Why of Asbestos Carcinogenesis
University of WashingtonClement Furlong
Biomarkers of Exposure & Paraoxonases as Biomarkers of Suscept ibility for Environmentally-Induced Diseases
University of California-DavisAlan R. Buckpit t
Species Differences in Naphthalene Toxicity:Implicat ions for Humans
University of IowaKeri Hornbuckle
Industrial Chemicals in Urban Environments: Airborne PCBs & their Sources
University of ArizonaRaina Maier
Phytostabilizat ion of Mine Tailings in Arid Environments: Plant Establishment and Tailings Characterizat ion
Dartmouth CollegeCelia Y Chen
Ecological Factors Controlling Metal Bioaccumulat ion & TrophicTransfer in Aquat ic Food Webs
Michigan State UniversityJames Tiedje
Using High Throughput DNA Sequencing to Better Characterize PCB, PAH, & Dioxin
Biodegradat ion Capacit ies in Environmental Matrices
For more information please contact Agency for Toxic Substances and Disease Registry
4770 Buford Hwy. NE, Chamblee, GA 30341 Telephone: 1-800-CDC-INFO (232-4636)/TTY: 1-888-232-6348E-mail: [email protected] Web: www.atsdr.cdc.gov
The findings and conclusions in this report are those of the authors and do not necessarily represent the official position of the Centers for Disease Control and Prevention.
NCEH/ATSDRLooks Forward To Meeting
More SRP Scient ists in
2011 !
Agency for Toxic Substances and Disease RegistryNational Center for Environmental Health