Research Integrity Lecture Series

A rude awakening and a journey to improved data storage and curation

or Making Lemonade and the Search for Practical Data Solutions for Investigators

Mark E Anderson, MD, PhD

DisclosuresName Type of Financial

RelationshipName of Company

Mark Anderson, M.D., Ph.D.

Grant Research Funding NIH/NHLBI

Ownership Interest Allosteros Therapeutics

Jeanne Clark, M.D., M.P.H. Grant/Research NIH/NIDDK

Grant/Research PCORI

An Overview

• A Google search and a rude awakening (12/2012)

• Hiding in plain sight

• Early efforts to improve data storage and curation in our lab

• Repeating experiments

• The ORI process, sanctions (11/2014), retractions and reflection

• Reaching out and learning that (almost) no one has a data solution

• What is expected of you – by the NIH, by journals, by Johns Hopkins?

• Using this experience as a motivation to advance data storage and curation for researchers

• Various solutions, some clear limitations and next steps

Public scrutiny: hiding in plain site

Greuter Mol Cell 2009

Lab meeting discussions and developing a policy

• Science fraud website

• Brainstorming

• What is the goal

• What can be achieved?

• Our ‘solution’

• Looking for more

• A silent period and repeating experiments

• ORI sanctions Dzhura

Igor Dzhura, PhD

Dzhura Nat Cell Biol 2000

ORI (Office of Research Integrity)

Reaching out

• 23 coauthors

• ~75 collaborators, friends and mentors

• Search committee chair

• Many have had a close call and no one has a coherent plan

NIH

Journals

University

What is expected of you?

http://www.hopkinsmedicine.org/som/faculty/policies/facultypolicies/responsible_conduct.html

Bottom line: Johns Hopkins owns the data but you are responsible for custody

Indemnification, guidance, resources….

Various solutions, some clear limitations and next steps

Clinical versus non-clinicalLarge data setsWhat are primary data?What are the goals and a quest for practical solutions?

Panel Discussion

• SOM Data Integrity and Curation Task Force Mark E. Anderson, MD, PhDJeanne Clark, MDJulie Gottlieb, MAGregory Kirk, MD, MPH, PhDMollie K. Meffert, MD, PhDBrian O’Rourke, PhDStuart C. Ray, MD, FIDSARandall Reed, PhDAntony Rosen, MDGary Rosner, ScD

• Goal: develop best practices and data storage solutions for investigators

• Best probably does not mean perfect

• Practical first steps based on the question “can you readily locate data from a certain figure in a paper you published 5-10 years ago?”

Panel Discussion

• Mark Anderson, M.D., Ph.D.• Jeanne Clark, M.D., M.P.H.• Gary Rosner, SCD• Stuart Ray, M.D.

• Julie Gottlieb, M.A - Moderator