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Research Infrastructures in
Structural Biology and Framework Programme 7
The role of NMR
Lucia BanciCERM, Florence, Italy
Workshop organized by the RI Division of EC, Brussels,16th March 2005
Future Needs for Research Infrastructures in Biomedical Sciences in FP7
Needs for supporting existing research infrastructures at the EU-level• A need for improved coordination at EU level: the case of bio-repositories• The support to facilities for Protein Structure determination. Status and future needs• Infrastructures in Genomics and Proteomics • Mapping existing infrastructures in Biomedical Sciences
Needs for new research infrastructures at EU-level• Needs for new infrastructures as analysed by the ESFRI - “Biology and Medical Sciences” • The access to information from molecular biology and genome research • The future of imaging facilities in Europe• New developments for Ion and X-Ray radiation therapy research facilities• Clinical research: A need for constructing a new European infrastructure?
Funding from EC to BioNMR RI (1994-2005)
FP3 Limited Transnational access funded to the individual Infrastructures (RI)
FP6 Transnational access funding has been approved and available to the community from end of the year
• “Design study” project under negotiation
FP4 Transnational access funded to each RI which formed a cluster • Concerted Action involving other EU NMR laboratories
• RTD’s
FP5 Transnational access funded to each RI which formed a cluster • Cluster formalization through ICN common access protocol • RTD’s
Future Needs for existing BioNMR RI
• Support for technological/methodological advancement of the Infrastructures
“Design studies” are an excellent instrument for forefront advancement of RI
• More funds for instruments: – keep the instrumentation updated
EC could support about 20% depreciation cost/year
– acquire new equipment to comply User’s needs
• Reestablish access for European researchers:
– Remote Access should be promoted
Increased support for technical staff
The European Strategy Forum on Research Infrastructures
(ESFRI)
• ESFRI started in 2002 as an initiative of the Governments of the EU states
• it brings together the representatives of:- 25 EU Member States- 7 Associated Countries - European Commission
ESFRI activities:
• set up thematic working groups• act as incubator of Research Infrastructures Projects• prepare a roadmap for Research Infrastructures of pan-European interest in the next 10-20 years (http://cordis.lu/esfri/)
ESFRI
Physical Sciences and Engineering (PSE)
Biological and Medical Sciences (BMS)
Social Sciences and Humanities (SSH)
• Advanced infrastructure for brain and whole body imaging• Bio-informatics infrastructure for Europe• European network of advanced clinical research centers• European network of bio-banks and genomic resources• High security laboratories for emerging diseases and threats to public health• Infrastructure for functional analysis of a whole mammalian genome• Model testing facilities for biomedical research• Integrated Structural Biology Infrastructure for Europe
The BMS Steering Group has proposed the following Infrastructures to be established in FP7
Future Scientific Needs
Integrated Structural Biology Infrastructure for Europe
Bioinformatics Clinical records
PrioritizationModule
Structural Biology
HT Expression Module
Chemical Biology
Biomedical Applications
COORDINATION ACTION
Focusing NMR on the machinery of Life - NMR-Life
Main goals: 1. foster cross-fertilization between the four different scientific areas of this project, mainly through the common vertical aspects;2. contribute to the development and dissemination of common good practices and methodological approaches;3. foster the transfer of knowledge among different research teams, thereby enhancing the spreading of innovative methods and tools;4. implement a common reference point for the European NMR community in the internet, by maintaining a common virtual laboratory;5. jointly identify bottlenecks and possible breakthroughs in the field of biological NMR.
COORDINATION ACTION
Focusing NMR on the machinery of Life - NMR-Life
The PartnersThe Partners:1. Center for Magnetic Resonance Florence (CERM) - I.Bertini 2. European molecular biology laboratory (EMBL) - M.Sattler3. Utrecht University (RUUTR) - R.Boelens 4. Johann Wolfgang Goethe-University (BMRZ) - H.Schwalbe5. Forschungsinstitut fur molekulare pharmakologie (FMP) - H.Oschkinat 6. Ecole Normale Supérieure de Paris (ENS) - G.Bodenhausen7. Københavns Universitet (UKBH) - F.Poulsen 8. Masaryk University (P F MU) - V.Sklenar9. University of Cambridge (UCAM) - E.Laue10. University of Oxford (UOXF) - I.Campbell
COORDINATION ACTION
Focusing NMR on the machinery of Life - NMR-LifeEstimated relative need for coordination activities of scientific areas as a function of the methodological aspects considered: * Average; ** High; *** Very high.
Sample production and
preparation
NMR methods High-molecular-
weight systems
Software tools
Protein-protein interactions ** *** ** ***
Protein-DNA/RNA interactions
*****
** ***
Protein-ligand interactions * ** * ***
Membrane and immobilized proteins
*** *** *** **
Forum for European Structural Proteomics (FESP) www.ec-fesp.org
Supported by EC as Specific Supported Action (SSA)
Lucia Banci, Centro Risonanze Magnetiche, University of Florence, Italy
Wolfgang Baumeister, Max-Planck-Institute of Biochemistry, Martinsried, Germany
Udo Heinemann, Max-Delbrück-Centrum für Molekulare Medizin, Berlin Germany
Gunter Schneider, Karolinska Institutet, Stockholm Sweden
Joel Sussman, Weizmann Institute of Science, Rehovot Israel - Coordinator
Goals
• Assess Structural Genomics/Proteomics projects already in action at national, European, and global level.
• Assess existing Infrastructures (synchrotrons, NMR, EM,
Protein Production, Bioinformatics) with respect to the needs for Structural Genomics/Proteomics in Europe, and comparison with the status in the rest of the world
• Develop strategic plans for an European policy in Structural Genomics/ Proteomics
Outcomes
• A database will be established and it will serve as a complete register of the Structural Genomics/Proteomics projects worldwide
• A position paper which includes -- assessment of Structural Genomics/Proteomics Infrastructures and activities in Europe and worldwide
-- a strategic road map to guide future directions of SG and SP initiatives in EU
To achieve these goals the active contribution of the entire SG/SP community is needed and sought for
Contributions will be collected from:
Interactions with the Infrastructures involved in SG/SP activities
installation of a web site www.ec-fesp.org collecting contributions to the debate targeted workshops
For the debate aimed at the
identification of new strategic areas and directions to be addressed in future projects
