May – June 2019ReseaRch Bulletin

Corneliu Sima, DMD, DMSc, MMSc, assistant professor of Oral Medicine, Infection, and Immunity, received supplemental funding from NIH/NIDCR for a new collaboration with Dr. Xiao Han, associate member of the staff at the Forsyth Institute. This

funding is supplemental to his parent R01, “Regulatory B Cells in the Amelioration of Immune-Mediated Periodontal Disease.” The research will assess interactions between B10 cells and monocytes/macrophages in resolution of periodontal inflammation. The project will help establish a strong collaboration to bridge the knowledge gap in innate-adaptive immune cell interactions during resolution of periodontitis, and to advance noninvasive imaging approaches for craniofacial immunology research.

RESEARCh AWARDS

Alessandro Villa, DDS, PhD, MPh, assistant professor of Oral Medicine, Infection, and Immunity, program director for the Oral Medicine Residency Program, and associate surgeon in the Division of Oral Medicine and Dentistry at Brigham

and Women’s Hospital, received an award from NIH/National Network of Libraries of Medicine. The overall goal of his project is to increase Human Papilloma Virus (HPV) awareness among oral health providers working with American Indian populations and therefore increase HPV vaccination rates. HPV is the most common sexually transmitted infection in the United States.

The Global health Starter Kit Launches

The HSDM Office of Global and Community Health has officially launched the Global Health Starter Kit. This project is led by Brittany Seymour, DDS, MPH, assistant professor

of Oral Health Policy and Epidemiology, and the Global Oral Health Interest Group of the Consortium of Universities for Global Health. Seymour is the editor and co-editors include, Janice Cho, PharmD, DMD and Jane Barrow, MS, both lecturers in Oral Health Policy and Epidemiology. It is a competency-based global health ‘starter’ curriculum designed for dental educators and students. It is free and available for anyone to use and is organized into two versions, one for educators and one for learners. The Global Health Starter Kit,https://hsdm.harvard.edu/global-health-starter-kit is funded by the Consortium of Universities for Global Health, Dr. Thomas Hall Global Health Education Grant, and International College of Dentists USA Section Foundation.

We are excited to announce that Jane Barrow, associate dean for Global and Community Health and executive director of HSDM’s Initiative to Integrate Oral Health and Medicine, has been awarded the 2019 Joseph B. Martin Dean’s Leadership Award for the Advancement of Women Staff. Photographed left to right – Dr. Christine Riedy, Dr. John Da Silva, Dr. Lisa Simon, Ms. Jane Barrow, Ms. Christina Cassano, and Dr. Brittany Seymour.

2 Research Bulletin • May – June 2019 • Harvard School of Dental Medicine

NEW RESEARCh STAFFAkiri Yamakawa, MD, PhD, joined the Yang Lab as a postdoctoral research fellow in the Department of Developmental Biology. Yamakawa received his PhD from the Graduate School of Medicine at the University of Tokyo, Tokyo, Japan and MD from the School of Medicine at Kanazawa University, Ishikawa, Japan. Yamakawa’s PhD work under the mentorship of Professors Shinsuke Ohba and Ung-il Chung, focused

on the identification of a chondrocyte-specific Indian hedgehog enhancer by a genome-wide approach and the investigation of the Sox9-mediated mechanisms of the enhancer activation. In Yang Lab, Yamakawa will focus on the function of Wnt5a/PCP signaling in chondrocyte stem cell regulation in the growth plate.He is partially funded by a grant from the Japanese Orthopaedics and Traumatology Research Foundation.

Arielle Mather, MPh & Jamie BichelmanThe Department of Oral Health Policy and Epidemiology (OPHE) is pleased to welcome Arielle Mather and Jamie Bichelman to HSDM.

Arielle serves as Program Manager for the National Center for Equitable Care for Elders (NCECE), a HRSA-funded project housed within OHPE. Arielle will oversee the planning and delivery of the Center’s trainings and technical assistance activities. She has spent many years in the Boston nonprofit sector addressing the needs of older and vulnerable populations, as well as the providers who care for them. Arielle received her Master of Public Health from Tufts University School of Medicine, where she concentrated in health communication.

Jamie serves as the Communications Coordinator for the NCECE and will oversee outreach and engagement through social media content production, website management, and the development of brochures and other literature. Jamie will be responsible for designing and facilitating the dissemination of informative program-related marketing materials to a wide range of internal and external stakeholders and brings more than 12 years of experience in journalism, marketing, and content production.

Dr. Francesca Gori Joins the Office of Research

Starting July 1st, Dr. Gori will work closely with all DMD students on their research coursework and requirements. Gori received her PhD in biology from the University of Florence, Italy and competed her postdoctoral work at the Mayo Clinic. Gori then decided to pursue a career in basic research in the US and joined the Endocrine Unit at Massachusetts General Hospital. She is now assistant professor in the Department of Oral Medicine, Infection and Immunity in the Baron-Gori Lab. Her work focuses on investigating the molecular, cellular, and genetic basis of skeletal homeostasis and its regulation in health and disease with emphasis on the mechanisms by which Wnt signaling regulates bone homeostasis.

Gori will work with Dawn DeCosta, director of Research Operations at HSDM with oversight from the associate deans for Research, Dr. Malcolm Whitman and Dr. Yingzi Yang. The Office of Research supports student research experiences in basic science, clinical and translational research, health services and global health research. Please do not hesitate to reach out to any member of the Office of Research with questions or concerns during this transition.

Research Bulletin • May – June 2019 • Harvard School of Dental Medicine 3

Mitwalli H, Mourao M, Dennison J, Yaman P, Paster B, Fontana M. Effect of silver diamine fluoride treatment on microbial profiles of plaque biofilms from root/cervical caries lesions. Caries Research 2019;1-12.

Nagano K. R-spondin signaling as a pivotal regulator of tissue development and homeostasis. Japanese Dental Science Review 2019;55(1):80-87.

Robledo-Sierra J, Ben-Amy D, Varoni E, Bavarian R, Simonsen J, Paster B, Wade W, Kerr R, Peterson D, Frandsen Lau E. World Workshop on Oral Medicine VII: Targeting the oral microbiome Part 2: Current knowledge on malignant and potentially malignant oral disorders. Oral Diseases 2019;25-1:28-48

Shinjo T, Ishikado A, Hasturk H, Pober D, Paniagua S, Shah H, Wu I, Tinsley L, Matsumoto M, Keenan H, Van Dyke T, Genco R, King G. Characterization of periodontitis in people with type 1 diabetes of 50 years or longer duration. Journal of Periodontology 2019; Apr 26.

Varoni E, Bavarian R, Robledo-Sierra J, Ben-Amy D, Wade W, Paster B, Kerr R, Peterson D, Frandsen Lau E. World Workshop on Oral Medicine VII: Targeting the microbiome for oral medicine specialists-Part 1. A methodological guide. Oral Diseases 2019;25-1:12-27.

Villa A, Celentano A, Glurich I, Borgnakke W, Jensen S, Peterson D, Delli K, Ojeda D, Vissink A, Farah C. World Workshop on Oral Medicine VII: Prognostic biomarkers in oral leukoplakia: A systematic review of longitudinal studies. Oral Diseases 2019;25-1:64-78.

RESTORATIVE DENTISTRY AND BIOMATERIALS SCIENCESFurze D, Byrne A, Alam S, Brägger U, Wismeijer D, Wittneben J. Influence of the fixed implant-supported provisional phase on the esthetic final outcome of implant-supported crowns: 3-year results of a randomized controlled clinical trial.Clinical Oral Implants Research 2019; Jun 7.

Jamjoom F, Yilmaz B, Johnston W. Impact of number of registration points on the positional accuracy of a prosthetic treatment plan incorporated into a cone-beam computed tomography scan by surface scan registration: Clinical Oral Implants Research 2019; Jun 4.

Joda T, Gallucci G, Wismeijer D, Zitzmann N. Augmented and virtual reality in dental medicine: A systematic review. Computers in Biology and Medicine 2019;108:93-100.

Ohyama H, Hamilton A, Forman M, Weber HP. Comparative observation of immediate and late placement of dental implants with immediate loading: A 14-year follow up case report. Journal of Oral Implantology 2019; Apr 22.

ORAL AND MAxILLOFACIAL SuRGERY Carlson E, Tannyhill R. A foundational framework for andragogy in oral and maxillofacial surgery II: Interactive andragogies. Journal of Oral and Maxillofacial Surgery 2019;77(6):1101-1102.

Jazayeri H, Khavanin N, Yu J, Lopez J, Shamliyan T, Peacock Z, Dorafshar A. Fixation points in the treatment of traumatic zygomaticomaxillary complex fractures: A systematic review and meta-analysis. Journal of Oral and Maxillofacial Surgery 2019; Apr 30.

Resnick C, Doyle M, Calabrese C, Sanchez K, Padwa B. Is it cost effective to add an intraoral scanner to an oral and maxillofacial surgery practice? Journal of Oral and Maxillofacial Surgery 2019; Mar 23.

publications continued on page 4

hSDM PuBLICATIONS DEVELOPMENTAL BIOLOGYAn S, Zhang Y, Chen Q, Xiong B, Hao J, Zheng Y, Zhou X, Wang J. Effect of systemic delivery of Substance P on experimental tooth movement in rats. American Journal of Orthodontics and Dentofacial Orthopedics 2019;155(5):642-649.

Chen P, Tang T, Liu C, Wang B, Mian M, Oka C, Baquerizo M, Li Y, Xu L. High temperature requirement A1 protease as a rate-limiting factor in the development of osteoarthritis. American Journal of Pathology 2019; Apr 30.

Feigenson M, Jonason J, Shen J, Loiselle A, Awad H, O’Keefe R. Inhibition of the prostaglandin EP-1 receptor in periosteum progenitor cells enhances osteoblast differentiation and fracture repair. Annals of Biomedical Engineering 2019; Apr 12.

Fuente R, Gil-Peña H, Claramunt-Taberner D, Hernández-Frías O, Fernández-Iglesias Á, Alonso-Durán L, Rodríguez-Rubio E, Hermida-Prado F, Anes-González G, Rubio-Aliaga I, Wagner C, Santos F. MAPK inhibition and growth hormone: a promising therapy in XLH. FASEB Journal 2019; Apr 11.

Kim W, Cho YS, Wang X, Park O, Ma X, Kim H, Gan W, Jho E, Cha B, Jeung Y, Zhang L, Gao B, Wei W, Jiang J, Chung K, Yang Y. Hippo signaling is intrinsically regulated during cell cycle progression by APC/CCdh1. Proceedings of the National Academy of Sciences USA 2019; Apr 18.

Taubman M, Giannobile W. Robert J. Genco, DDS, PhD (1938-2019). Journal of Dental Research 2019;98(6):609-610.

Xiao L, Liu C, Wang B, Fei W, Mu Y, Xu L, Li Y. Targeting discoidin domain receptor 2 for the development of disease-modifying osteoarthritis drugs. Cartilage 2019; Jun 10.

Zhu S, Kuek V, Bennett S, Xu H, Rosen V, Xu J. Protein Cytl1: Its role in chondrogenesis, cartilage homeostasis, and disease. Cellular and Molecular Life Sciences 2019; May 14.

ORAL MEDICINE, INFECTION AND IMMuNITYAlmazyad A, Woo SB, Villa A. Persistent pain and gingival swelling in a middle-aged woman. JAMA Otolaryngology – Head and Neck Surgery 2019; Apr 25.

Gueiros L, France K, Posey R, Mays J, Carey B, Sollecito T, Setterfield J, Woo SB, Culton D, Payne A, Lodi G, Greenberg M, De Rossi S. World Workshop on Oral Medicine VII: Immunobiologics for salivary gland disease in Sjögren’s syndrome: A systematic review. Oral Diseases 2019;25-1:102-10.

Idelevich A, Sato K, Nagano K, Rowe G, Gori F, Baron R. ΔFosB requires galanin, but not leptin, to increase bone mass via the hypothalamus, but both are needed to increase energy expenditure. Journal of Bone and Mineral Research 2019; Apr 18.

Johnston C, Cotton S, Rittling S, Starr J, Borisy G, Dewhirst F, Lemon K. Systematic evasion of the restriction-modification barrier in bacteria. Proceedings of the National Academy of Sciences USA 2019; May 16.

Lotinun S, Ishihara Y, Nagano K, Kiviranta R, Carpentier V, Neff L, Parkman V, Ide N, Hu D, Dann P, Brooks D, Bouxsein M, Wysolmerski J, Gori F, Baron R. Cathepsin K-deficient osteocytes prevent lactation-induced bone loss and parathyroid hormone suppression. Journal of Clinical Investigation 2019 May 21;130.

Mays J, Carey B, Posey R, Gueiros L, France K, Setterfield J, Woo SB, Sollecito T, Culton D, Payne A, Greenberg M, De Rossi S. World Workshop of Oral Medicine VII: A systematic review of immunobiologic therapy for oral manifestations of pemphigoid and pemphigus. Oral Diseases 2019;25-1:111-21.

4 Research Bulletin • May – June 2019 • Harvard School of Dental Medicine

A PuBLICATION OF ThE OFFICE OF RESEARCh

188 Longwood Avenue, REB-404 – Boston, MA 02115 www.hsdm.harvard.edu – 617.432-1121

Malcolm Whitman, PhD, Associate Dean for Basic Science

Yingzi Yang, PhD, Associate Dean for Translational Research

Dawn M. DeCosta, Editor and Layout

heather M. Denny, Editing

Lia Sgourakes, Editing

Ashley Simmons, Editing and Photography

ORAL hEALTh POLICY AND EPIDEMIOLOGYChen M, Wright C, Tokede O, Yansane A, Montasem A, Kalenderian E, Beaty T, Feingold E, Shaffer J, Crout R, Neiswanger K, Weyant R, Marazita M, McNeil D. Predictors of dental care utilization in north-central Appalachia in the USA. Community Dentistry & Oral Epidemiology 2019; Apr 17.

Glicken A, Savageau J, Flick T, Lord C, Harvan R, Silk H. Integrating oral health: Physician assistant education in 2017. Journal of Physician Assistant Education 2019;30(2):93-100.

Haber J, Dolce M, Hartnett E, Savageau J, Altman S, Lange-Kessler J, Silk H. Integrating oral health curricula into midwifery graduate programs: Results of a US survey. Journal of Midwifery and Women’s Health 2019; Apr 29. Heaton B, Crawford A, Wimsatt M, Henshaw M, Riedy C, Barker J, Garcia R. A storytelling intervention reduces childhood caries risk behaviors among American Indian and Alaska Native mothers in Northern California. Journal of Public Health Dentistry 2019; Apr 23.

Khalid I, Chandrupatla S, Kaye E, Scott T, Sohn W. Dental sealant prevalence among children with special health care needs: National Health and Nutrition Examination Survey 2013 to 2014.Pediatric Dentistry 2019;41(3):186-190.

Nelson S, Albert J, Liu Y, Selvaraj D, Curtan S, Ryan K, Pinto A, Ejaz F, Milgrom P, Riedy C. The psychometric properties of a new oral health illness perception measure for adults aged 62 years and older. PLoS One 2019;14(4):e0214082.

Simon L, Obadan-Udoh E, Yansane A, Gharpure A, Licht S, Calvo J, Deschner J, Damanaki A, Hackenberg B, Walji M, Spallek H, Kalenderian E. Improving oral-systemic healthcare through the interoperability of electronic medical and dental records: An exploratory study. Applied Clinical Informatics 2019 May;10(3):367-376.

Simon L, Tobey M, Wilson M. Feasibility of integrating a dental hygienist into an inpatient medical team for patients with diabetes mellitus. Journal of Public Health Dentistry 2019; Apr 24.

MuLTI-DEPARTMENTALBesschetnova T, Brooks D, Hu D, Nagano K, Nustad J, Ominsky M, Mitlak B, Hattersley G, Bouxsein M, Baron R, Lanske B. Abaloparatide improves cortical geometry and trabecular microarchitecture and increases vertebral and femoral neck strength in a rat model of male osteoporosis. Bone 2019; Apr 30.

Chang J, Li C, Achtari M, Stoufi E. Crohn’s disease initiated with extraintestinal features. British Medical Journal Case Reports 2019;12(4).

Dolce M, Parker J, Savageau J, Da Silva J. Older adult patients’ experience of care in a dental school clinic. Journal of Dental Education 2019; May 27.

Nedjat-Haiem F, Cadet T, Amatya A, Thompson B, Mishra S. Efficacy of motivational interviewing to enhance advance directive completion in Latinos with chronic illness: A randomized controlled trial. American Journal of Hospice & Palliative Medicine 2019; May 23.

Dr. Asma Almazyad wins Shafer AwardDr. Almazyad, a fourth-year advanced graduate DMSc student in oral pathology, won the Shafer Award for the top scorer in the oral pathology fellowship exam. This is the first for HSDM, and speaks to the program’s excellence in not only research, but also in diagnostic pathology. Dr. Almazyad is photographed here with Dr. Sook-Bin Woo, associate professor of Oral Medicine, Infection and Immunity and advanced graduate education program director for the Oral and Maxillofacial Pathology specialty training program.

hSDM SCIENCE TALKS11:00 am -12:00 pm in the REB Auditorium

• september 12, 2019 Dr. Ling Qin (Penn)

• October 10, 2019 Dr. Ben Levi (Michigan)

• november 14, 2019 Dr. Terry Capellini (harvard)

• December 12, 2019 Dr. Jie Song (uMass)

• January 16, 2020 Dr. Eileen Shore (Penn)

• February 13, 2020 to Be Determined

• March 12, 2020 Dr. Matt Greenblatt (cornell)

• april 16, 2020 Dr. Tamara Alliston (ucsF)

• May 14, 2020 Dr. Catherine McCusker (uMass)