ResearchVOLUME 48 •¿�NUMBER 22 •¿�CNREA8 •¿�PP 6257-6623

CONTENTSf

Asterisks # preceding page numbers refer to studies using human-derived material.

6257

BASIC SCIENCES

Use of a Mammalian Cell Culture Benzo(a)p}Tene MetabolismAssay for the Detection of Potential Anticarcinogens from Natural Products: Inhibition of Metabolism by Biochanin A, an Iso-flavone from Trifoliumpratense L. John M. Cassady, Thomas M.Zennie, Young-Heum Chae, Mark A. Ferin, Nuris E. Portuondo,and William M. Baird.

Blocking of Collagenase Secretion by Estramustine during inVitro Tumor Cell Invasion. Min Wang and Mark E. Stearns.

Clonal Analysis of Untreated Non-Hodgkin's Lymphoma Utilizing Immunoglobulin Gene Rearrangement and Immu-nophenotype. Richard A. Rudders, Satinder Dhillon, andTheodore G. Kremlins.

A Possible Effect of Heme on the Fate of DNA Ligase ActivityExtracted from Differentiating Mouse Erythroleukemia Cells.Barbara M. Scher, William Scher, and Samuel Waxman.

Quantitätenof Primary in Vitro Clonogenic Keratinocytes fromNormal Adult Murine Epidermis, following Initiation, and duringPromotion of Epidermal Tumors. Rebecca J. Morris, Kay C.Tacker, Susan M. Fischer, and Thomas J. Slaga.

Combined Modality Therapy with Bleomycin, Hyperthermia, andRadiation. Beverly A. Teicher, Terence S. Herman, and Sylvia AHolden.

DNA Replication in Syrian Hamster Cells Transiently Exposedto Hydroxyurea. David C. Creasey and Paul O. P. Ts'o.

Enhanced Cytotoxicity against Colon Carcinoma by Combinationsof Noncompeting Monoclonal Antibodies to the 17-1A Antigen.William E. Fogler, Mark R. Klinger, Katalin G. Abraham,Heinrich G. Gottlinger, Gert Riethmuller, and Peter E. Daddona.

6309 Gene Expression during the Early Phases of Regression of theAndrogen-dependent Shionogi Mouse Mammary Carcinoma.Paul S. Rennie, Nicholas Bruchovsky, Ralph Buttyan, MitchellBenson, and Helen Cheng.

6313 Boron Neutron Capture Therapy of a Murine Melanoma. JeffreyA. Coderre, John A. Kalef-Ezra, Ralph G. Fairchild, Peggy L.Micca, Lawrence E. Reinstein, and John D. Glass.

6317 L-Ascorbic Acid Amplification of Second-Stage Bladder Carcino-genesis Promotion by NaHCO3. Shoji Fukushima, KatsumiImaida, Masa-Aki Shibata, Seiko Tamaño,Yasushi Kurata, andTomoyuki Sturai.

* 6321 Infiltration of Interleukin-2-inducible Killer Cells in Ascitic Fluidand Pleural Effusions of Advanced Cancer Patients. D. KayBlanchard, John J. Kavanagh, Joseph G. Sinkovics, DenisCavanagh, Susan M. Hewitt, and Julie Y. Djeu.

$6328 Immunological Detection of Aflatoxin B,-DNA Adducts Formedin Vivo. Ling-Ling Hsieh, Shang-Wei Hsu, Ding-Shinn Chen, andRegina M. Santella.

*6262

*6272

6278

6285

6291

6298

*6303

6332 Enhancement by Prolonged Administration of Caerulein of Experimental Carcinogenesis Induced by W-Methyl-yV'-nitro-M-

nitrosoguanidine in Rat Stomach. Masaharu Tatsuta, Hiroyasulishi, Miyako Baba, Hisako Yamamura, and Haruo Taniguchi.

* 6336 Immunochemical Quantitation of DNA Adducts Derived from theHuman Bladder Carcinogen 4-Aminobiphenyl. Dean W. Roberts,R. Wayne Benson, John D. Groopman, Thomas J. Flammang,William A. Nagle, A. J. Moss, and Fred F. Kadlubar.

* 6.143 Relation between the Human Fibroblast Strain 46BR and CellLines Representative of Bloom's Syndrome. Alan R. I chinami,

Anne E. Willis, Bernard C. Broughton, Michael R. James, HerdisSteingrimsdottir, Susan A. Harcourt, Colin F. Arlett, and TomasLindahl.

* 6348 Increased mar Gene Expression and Decreased Drug Accumulation in Multidrug-resistant Human Melanoma Cells. Jeffrey F.Lemontt, Marie Azzaria, and Philippe Gros.

*635-t Increased Glyceraldehyde-3-phosphate Dehydrogenase Gene Expression in Human Pancreatic Adenocarcinoma. Nancy Schek,Bruce Lee Hall, and Olivera J. Finn.

* 636(1 Direct Relation of DNA Lesions in Multidrug-resistant HumanMyeloma Cells to Intracellular Doxorubicin Concentration.William T. Bellamy, Robert T. Dorr, William S. Dalton, andDavid S. Alberts.

* 6365 Verapamil Reversal of Doxorubicin Resistance in Multidrug-resistant Human Myeloma Cells and Association with Drug Accumulation and DNA Damage. William T. Bellamy, William S.Dalton, Jenai M. Kailey, Mary C. Gleason, Thomas M.McCloskey, Robert T. Dorr, and David S. Alberts.

6371 Differential Regulation of Normal and Tumor a,-FetoproteinGenes in Fetal Hepatocyte x Hepatoma Hybrids. Marie-ClaudeGingras, Josiane Szpirer, Bernard Turcotte, Luc Bélanger,andClaude Szpirer.

6375 Liver Microsomal Inactivation of 4-Methyl-5-amino-l-formyliso-quinoline Thiosemicarbazone as an Inhibitor of RibonucleotideReductase. Marvin T. Williams, Lizette Simonet, Ann H. Cory,and Joseph G. Cory.

* 6379 Proteases in Cyst Fluid from Human Gross Cyst Breast Disease.Leo Kesner, Wanshang Yu, H. Leon Bradlow, Charles W. Breed,and Martin Fleisher.

^6384 Modulation of Plasminogen Activator Activity in Human Endo-metrial AdenocarcinomaCells by Basic Fibroblast Growth Factorand TransformingGrowth Factor ß.Marco Presta, Jeanette A. M.Maier, Marco Rusnati, David Moscatelli, and Giovanni Ragnotti.

6390 Alterations in Epidermal Polyamine Levels and DNA Synthesisfollowing Topical Treatment with Chrysarobin in SENCAR Mice.Francis H. Kruszewski and John DiGiovanni.

6396 Improved Antitumor Effects of Immunotoxins Prepared with De-glycosylated Ricin A-Chain and Hindered Disulfide Linkages.Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles, MicheleG. Reif, Alex N. F. Brown, Graham J. Watson, David C. Blakey,and David R. Newell.

t The CONTENTS arranged by Subject Category can be found immediately following these CONTENTS.

Research. on August 14, 2021. © 1988 American Association for Cancercancerres.aacrjournals.org Downloaded from

6404 Camptothecin-resistant Mutants of Chinese Hamster Ovary CellsContaining a Resistant Form of Topoisomerase I. Radhey S.Gupta, Rajni Gupta, Barry Eng, Richard B. Lock, Warren E.Ross, Robert P. Hertzberg, Mary Jo Caranfa, and Randall K.Johnson.

6411 Identification of a Platelet-aggregating Factor of Murine ColonAdenocarcinoma 26: U, 44,000 Membrane Protein as Determined by Monoclonal Antibodies. Masahiko Watanabe, EtsukoOkochi, Yoshikazu Sugimoto, and Takashi Tsuruo.

$6417 Preclinical Studies and Clinical Correlation of the Effect of Al-kylating Dose. Emil Frei III, Beverly A. Teicher, Sylvia A.Holden, Kathleen N. S. Cathcart, and Yenyun Wang.

* 6-42-4 Production of Growth Potentiating Factor(s) for Autologous Blast

Cells by Acute Myeloblastic Leukemia Cells. Ikuo Murohashi,Kaoru Nagata, Toshiya Suzuki, Yoko Yamashita, YasuoMaruyama, and Nobuo Nara.

$6429 Insulin-like Growth Factor 1 Receptors in Human Breast Cancerand Their Relation to Estradiol and Progesterone Receptors. J-P.Peyrat, J. Bonneterre, R. Beuscart, J. Djiane, and A. Démaille.

6434 In Vitro Estrogen-like Effects of 7,12-Dimethylbenz(<i)-anthracene on Anterior Pituitary Dopamine Receptors of Rats.Catherine Pasqualini, Florence Bojda, and Bernard Kerdelhue.

6438 Autocrine Production of Pre-B-Cell Stimulating Activity by a Variety of Transformed Murine Pre-B-Cell Lines. Francois M.Lemoine, Gerald Krystal, R. Keith Humphries, and Connie J.Eaves.

6444 Comparison between the DNA Precipitation and Alkali Unwinding Assays for Detecting DNA Strand Breaks and Cross-Links.Peggy L. Olive, Angela P. S. Chan, and Carissa S. Cu.

6450 Induction of High-Grade Tumor-specific Immunity in a HostUsing a Cytotoxic T-Lymphocyte Clone Specific for a StableTumor Antigen on Murine Leukemia 1,1210. S. M. JamshedurRahman, Kohei Kawashima, Izumi Nakashima, and FumihikoNagase.

6455 Chromosomal Translocations with Specific Breakpoints in Asbestos-induced Rat Mesotheliomas. Bisharah L. Libbus and JohnE. Craighead.

* 6-462 Immunocytochemical Localization of Progesterone Receptors inBreast Cancer with Anti-Human Receptor Monoclonal Antibodies. Dorraya Elashry-Stowers, David T. Zava, Wendell C.Speers, and Dean P. Edwards.

6475 Lack of Binding of Methapyrilene and Similar Antihistamines toRat Liver DNA Examined by 'T Postlabeling. W. Lijinsky and

K. Yamashita.

6478 Nuclear Fragmentation and Premature Chromosome Condensation Induced by Heat Shock in S-Phase Chinese Hamster OvaryCells. Michael A. Mackey, William F. Morgan, and William C.Dewey.

6484 Characterization of Chromium Effects on a Rat Liver EpithelialCell Line and Their Relevance to in Vitro Transformation.JudithA. Briggs and Robert C. Briggs.

$6491 Aromatization of Testosterone by Epithelial Tumor Cells Cultured from Patients with Ovarian Carcinoma. Margaret A.Thompson, Mark D. Adelson, Lydia M. Kaufman, Linda D.Marshall, and Denis A. Coble.

6498 a-Difluoromethylornithine-induced Inhibition of Growth of Autochthonous Experimental Colonie Tumors Produced by Azox-ymethane in Male F344 Rats. Shao-Zeng Zhang, Gordon D. Luk,and Stanley R. Hamilton.

6504 Loss of Metastatic and Primary Tumor Factor X Activator Capabilities by Lewis Lung Carcinoma Cells Cultured in VitaminK-dependent Protein Deficient Serum. Michael J. Fasco, GeorgeE. Eagan, Adrian C. Wilson, John F. Gierthy, and David L.Lincoln.

Quantitative Studies on the Transplantubilit> of Murine and Human Tumors into the Brain and Subcutaneous Tissues ofNCr/Sed Nude Mice. Anthony L. Zietman, Herman D. Suit,Jonathan R. Ramsay, Vlatko Silobrcic, and Robert S. Sedlacek.

* 6517 Immunocytochemical Localization of Estrogen Receptor in Human Breast Tissue. Kerry J. Walker, Nasser Bouzubar, JohnRobertson, Ian O. Ellis, Christopher W. Elston, Roger W.Blarney, Douglas W. Wilson, Keith Griffiths, and Robert I.Nicholson.

* 6523 Intranucleolar Localization of Human Proliferating Cell Nucleo-lar Antigen pi 20. Robert L. Ochs, Mary T. Reilly, James W.Freeman, and Harris Busch.

* 6530 Neuronal Cell Differentiation of Human Neuroblastoma Cells byRetinoic Acid plus Herbimycin A. Peter N. Preis, Hideyuki Saya,I as/lo Nádasdi, Guenther Hochhaus, Victor Levin, andWolfgang Sadée.

$6535 Partial Down-Regulation of Protein Kinase C in C3H lili1.'Mouse Fibroblasts Transfected with the Human IIu-ru.vOncogene. Crystal M. Weyman, Elizabeth J. Taparowsky, MarinaWolfson, and Curtis L. Ashendel.

6542 Cytoplasmic Accumulation of Ditercalinium in Rat Hepatocytesand Induction of Mitochondria! Damage. Robert Fellous,Dominique Coulaud, ImánEl Abed, Bernard P. Roques, Jean-Bernard Le Pecq, Etienne Detain, and Alain Gouyette.

6550 Altered Expression of NM23, a Gene Associated with LowTumor Metastatic Potential, during Adenovirus 2 Eia Inhibitionof Experimental Metastasis. Patricia S. Steeg, GenerosoBevilacqua, Rudy Pozzatti, Lance A. Liotta, and Mark E. Sobel.

6555 Intervention of T-Cells in Transportation of Mouse MammaryTumor Virus (Milk Factor) to Mammary Gland Cells in Vivo.Airo Tsubura, Muneo Inaba, Shunsuke Imai, Akira Murakami,Naoki Oyaizu, Ryoji Yasumizu, Yoko Ohnishi, HarutakaTanaka, Sotokichi Morii, and Susumu Ikehara.

6560 Effects of Butyrate on Epidermal Growth Factor Receptor Binding, Morphology, and DNA Synthesis in Cultured Rat Hepatocytes. Ivar P. Gladhaug, Magne Refsnes, Tor-Erik Sand, andThoralf Christoffersen.

$6565 New Monoclonal Antibody, 1C5, Reactive with Human CervicalAdenocarcinomaof the Uterus, with Immunodiagnostic Potential.Motoiki Koizumi, Toshimitsu Uede, Noriharu Shijubo, RyuichiKudo, Masayoshi Hashimoto, and Kokichi Kikuchi.

$6573 In Vivo Localization of Human Colon Adenocarcinoma by Monoclonal Antibody Binding to a Highly Expressed Cell Surface Antigen. Hiroshi Takahashi, Byron Wilson, Mehmet Ozturk, PhilippeMotte, William Strauss, Kurt J. Isselbacher, and Jack R. Wands.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

6580 Incidence of Lung Cancer by Histological Type from a Population-based Registry. Hoda Anton-Culver, B. Dwight Culver, TomKurosaki, Kathryn E. Osann, and Jason Bok Lee.

6584 Phase I Study of Difluoromethylornithine in Combination withRecombinant a2a-Interferon. John H. Edmonson, John S.Kovach, Jan C. Buckner, Larry K. Kvols, and Richard G. Hahn.

Continued

Research. on August 14, 2021. © 1988 American Association for Cancercancerres.aacrjournals.org Downloaded from

6587 Phase I Trial of Lonidamine with Whole Body Hyperthermia inAdvanced Cancer. H. Ian Robins, Walter L. Longo, Rhonda K.Lagoni, Alan J. Neville, Anders Hugander, C. L. Schmitt, andChuck Riggs.

6593 Phase I Trial of the Amsacrine Analogue 9-{|2-Meth-oxy-4-((methylsulfonyl)amino|phenyl|aminoKV,5-dimethyl-4-ac-ridinecarboxamide (CI-921). Janet R. Hardy, Vernon J. Harvey,James W. Paxton, Pandora Evans, Shelba Smith, William Grove,Antonio J. Grillo-Lopez, and Bruce C. Baguley.

6597 Appearance and Phenotypic Characterization of Circulating Leu19+ Cells in Cancer Patients Receiving Recombinant Interleukin2. Thomas M. Ellis, Stephen P. Creekmore, John D. McMannis,Donald P. Braun, Jules A. Harris, and Richard I. Fisher.

6603 Relationship of Membrane-bound Tissue Type and UrokinaseType Plasminogen Activators in Human Breast Cancers to Estrogen and Epidermal Growth Factor Receptors. G. K. Needham,S. Nicholson, B. Angus, J. R. Farndon, and A. L. Harris.

6608 Association of DNA Content and Proliferate Activity with Clinical Outcome in Patients with Diffuse Mixed Cell and Large CellNon-Hodgkin's Lymphoma. Terry N. Wooldridge, Helen L.Grierson, Dennis D. Weisenburger, James O. Armitage, WarrenG. Sanger, Michaeleen M. Collins, Jene L. Pierson, Mary E.Pauza, RenéeFordyce, and David T. Purtilo.

6614 Nucleic Acid Flow Cytometry in Large Cell Lymphoma. PeterMcLaughlin, Barbara M. Osborne, Dennis Johnston, PaulJennings, James J. Butler, Fernando Cabanillas, and BartBarlogie.

6620 AnnouncementsEightieth Annual Meeting of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCollected Perspectives in Cancer ResearchRecent DeathCalendar of Events

6622 Author Index

Applications for active and corresponding membership and for associate membership in the American Association for Cancer Researchavailable in the back of this issue.

Research. on August 14, 2021. © 1988 American Association for Cancercancerres.aacrjournals.org Downloaded from

Cancer Research

VOLUME 48 •¿�NUMBER 22

CONTENTS Arranged by Subject Category

BASIC SCIENCES

Biochemistry and Biophysics

6278 A Possible Effect of Heme on the Fate of DNA Ligase ActivityExtracted from Differentiating Mouse Erythroleukemia Cells.Barbara M. Scher, William Scher, and Samuel Waxman.

6411 Identification of a Platelet-aggregating Factor of Murine ColonAdenocarcinoma 26: A/r 44,000 Membrane Protein as Determined by Monoclonal Antibodies. Masahiko Watanabe, EtsukoOkochi, Yoshikazu Sugimoto, and Takashi Tsuruo.

6560 Effects of Butyrate on Epidermal Growth Factor Receptor Binding, Morphology, and DNA Synthesis in Cultured Rat Hepato-cytes. Ivar P. Gladhaug, Magne Refsnes, Tor-Erik Sand, andThoralf ChristofTersen.

Carcinogenesis

6257 Use of a Mammalian Cell Culture Benzo(a)pyrene MetabolismAssay for the Detection of Potential Anticarcinogens from Natural Products: Inhibition of Metabolism by Biochanin A, an Iso-flavone from Trìfoliumpratense L. John M. Cassady, Thomas M.Zennie, Young-Heum Chae, Mark A. Ferin, Nuris E. Portuondo,and William M. Baird.

6285 Quantitation of Primary in Vitro Clonogenic Keratinocytes fromNormal Adult Murine Epidermis, following Initiation, and duringPromotion of Epidermal Tumors. Rebecca J. Morris, Kay C.Tacker, Susan M. Fischer, and Thomas J. Slaga.

6317 i.-Ascorbic Acid Amplification of Second-Stage Bladder Carcinogenesis Promotion by Nal KO,. Shoji Fukushima, KatsumiImaida. Masa-Aki Shibata, Seiko Tamaño,Yasushi Kurata, andTomoyuki Shirai.

$6323 Immunologia!) Detection of Aflatoxin B,-DNA Adducts Formedin Vivo. Ling-Ling Hsieh, Shang-Wei Hsu, Ding-Shinn Chen, andRegina M. Santella.

6332 Enhancement by Prolonged Administration of Caerulein of Experimental Carcinogenesis Induced by j\-Methyl-A''-nitnWV-ni-

trosoguanidine in Rat Stomach. Masaharu Tatsuta, Hiroyasulishi, Miyako Baba, Hisako Yamamura, and I lai UDTaniguchi.

* 6336 Immunochemical Quantitation of DNA Adducts Derived from theHuman Bladder Carcinogen 4-Aminobiphenyl. Dean W. Roberts,R. Wayne Benson, John D. Groopman, Thomas J. Flammang,William A. Nagle, A. J. Moss, and Fred F. Kadlubar.

6390 Alterations in Epidermal Polyamine Levels and DNA Synthesisfollowing Topical Treatment with Chrysarobin in SENCAR Mice.Francis H. Kruszewski and John DiGiovanni.

6475 Lack of Binding of Methapyrilene and Similar Antihistamines toRat Liver DNA Examined by 'T Postlabeling. W. Lijinsky and

K. Yamashita.

6484 Characterization of Chromium Effects on a Rat Liver EpithelialCell Line and Their Relevance to in Vitro Transformation.JudithA. Briggs and Robert C. Briggs.

*6535 Partial Down-Regulation of Protein Kinase C in C3H lOT'/zMouse Fibroblasts Transfected with the Human lla-ra.v Oncogene. Crystal M. Weyman, Elizabeth J. Taparowsky, MarinaWolfson, and Curtis L. Ashendel.

Endocrinology

6309

6434

*6462

*64'M

*6517

* 6303

*6321

6450

*6523

*f>565

6298

$6343

Gene Expression during the Early Phases of Regression of theAndrogen-dependent Shionogi Mouse Mammary Carcinoma.Paul S. Rennie, Nicholas Bruchovsky, Ralph Buttyan, MitchellBenson, and Helen Cheng.

In Vitro Estrogen-like Effects of 7,12-Dimethylbenz(a)anthra-cene on Anterior Pituitary Dopamine Receptors of Rats.Catherine Pasqualini, Florence Bojda, and Bernard Kerdelhue.

Immunocytochemical Localization of Progesterone Receptors inBreast Cancer with Anti-Human Receptor Monoclonal Antibodies. Dorraya Elashry-Stowers, David T. Zava, Wendell C.Speers, and Dean P. Edwards.

Aromatization of Testosterone by Epithelial Tumor Cells Cultured from Patients with Ovarian Carcinoma. Margaret A.Thompson, Mark D. Adelson, Lydia M. Kaufman, Linda D.Marshall, and Denis A. Coble.

Immunocytochemical Localization of Estrogen Receptor in Human Breast Tissue. Kerry J. Walker, Nasser Bouzubar, JohnRobertson, Ian O. Ellis, Christopher W. Elston, Roger W.Blarney, Douglas W. Wilson, Keith Griffiths, and Robert I.Nicholson.

Immunology

EnhancedCytotoxicity against Colon Carcinoma by Combinationsof Noncompeting Monoclonal Antibodies to the 17-1A Antigen.William E. Fogler, Mark R. Klinger, Katalin G. Abraham,Heinrich G. Gottlinger, Gert Riethmuller, and Peter E. Daddona.

Infiltration of Interleukin-2-inducible Killer Cells in Ascitic Fluidand Pleural Effusions of Advanced Cancer Patients. D. KayBlanchard, John J. Kavanagh, Joseph G. Sinkovics, DenisCavanagh, Susan M. Hewitt, and Julie Y. Djeu.

Induction of High-Grade Tumor-specific Immunity in a HostUsing a Cytotoxic T-Lymphocyte Clone Specific for a StableTumor Antigen on Murine Leukemia LI 210. S. M. JamshedurRahman, Kohei Kawashima, Izumi Nakashima, and FumihikoNagase.

Intranucleolar Localization of Human Proliferating Cell Nucleo-lar Antigen pi 20. Robert L. Ochs, Mary T. Reilly, James W.Freeman, and Harris Busch.

New Monoclonal Antibody, 1C5, Reactive with Human CervicalAdenocarcinomaof the Uterus, with Immunodiagnostic Potential.Motoiki Koizumi, Toshimitsu (Jede, Noriharu Shijubo, RyuichiKudo, Masayoshi Hashimoto, and Kokichi Kikuchi.

Molecular Biology and Genetics

DNA Replication in Syrian Hamster Cells Transiently Exposedto Hydroxyurea. David C. Creasey and Paul O. P. Ts'o.

Relation between the Human Fibroblast Strain 46BR and CellLines Representative of Bloom's Syndrome. Alan R. Lehmann,

Anne E. Willis, Bernard C. Broughton, Michael R. James, HerdisSteingrimsdottir, Susan A. Harcourt, Colin F. Arlett, and TomasLindahl.

Increased mdr Gene Expression and Decreased Drug Accumulation in Multidrug-resistant Human Melanoma Cells. Jeffrey F.Lemontt, Marie Azzaria, and Philippe Gros.

' Indicates studies using human-derived material.

Research. on August 14, 2021. © 1988 American Association for Cancercancerres.aacrjournals.org Downloaded from

* 6354 Increased Glyceraldehyde-3-phosphate Dehydrogenase Gene Expression in Human Pancreatic Adenocarcinoma. Nancy Schek,Bruce Lee Hall, and Olivera J. Finn.

6371 Differential Regulation of Normal and Tumor a,-FetoproteinGenes in Fetal Hepatocyte x Hepatoma Hybrids. Marie-ClaudeGingras. Josiane Szpirer, Bernard Turcotte, Luc Bélanger,andClaude Szpirer.

6455 Chromosomal Translocations with Specific Breakpoints in Asbestos-induced Rat Mesotheliomas. Bisharah L. Libbus and JohnE. Craighead.

Preclinical Pharmacology and Experimental Therapeutics

6291 Combined Modality Therapy with Bleomycin, Hyperthermia, andRadiation. Beverly A. Teicher, Terence S. Herman, and Sylvia A.Holden.

6313 Boron Neutron Capture Therapy of a Murine Melanoma. JeffreyA. Coderre, John A. Kalef-Ezra, Ralph G. Fairchild, Peggy L.Micca, Lawrence E. Reinstein, and John D. Glass.

* 63611 Direct Relation of DNA Lesions in Multidrug-resistant HumanMyeloma Cells to Intracellular Doxorubicin Concentration.William T. Bellamy, Robert T. Dorr, William S. Dalton, andDavid S. Alberts.

*6365 \ erapa mil Reversal of Doxorubicin Resistance in Mult idrun-resistant Human Myeloma Cells and Association with Drug Accumulation and DNA Damage. William T. Bellamy, William S.Dalton, Jenai M. Kailey, Mary C. Gleason, Thomas M.McCloskey, Robert T. Dorr, and David S. Alberts.

6375 Liver Microsomal Inactivation of 4-Methyl-5-amino-l-formyliso-quinoline Thiosemicarbazone as an Inhibitor of RibonucleotideReducíase.Marvin T. Williams, Lizette Simonet, Ann H. Cory,and Joseph G. Cory.

6396 Improved Antitumor Effects of Immunotoxins Prepared with De-glycosylated Ricin A-Chain and Hindered Disulfide Linkages.Philip E. Thorpe, Philip M. Wallace, Phillip P. Knowles, MicheleG. Reif, Alex N. F. Brown, Graham J. Watson, David C. Blakey,and David R. Newell.

6404 Camptothecin-resistant Mutants of Chinese Hamster Ovary CellsContaining a Resistant Form of Topoisomerase I. Radhey S.Gupta, Rajni Gupta, Barry Eng, Richard B. Lock, Warren E.Ross, Robert P. Hertzberg, Mary Jo Caranfa, and Randall K.Johnson.

*64I7 Preclinical Studies and Clinical Correlation of the Effect of Al-kylating Dose. Emil Frei III, Beverly A. Teicher, Sylvia A.Holden, Kathleen N. S. Cathcart, and Yenyun Wang.

6444 Comparison between the DNA Precipitation and Alkali Unwinding Assays for Detecting DNA Strand Breaks and Cross-Links.Peggy L. Olive, Angela P. S. Chan, and Carissa S. Cu.

6498 a-Difluoromethylornithine-induced Inhibition of Growth of Autochthonous Experimental Colonie Tumors Produced by Azox-ymethane in Male F344 Rats. Shao-Zeng Zhang, Gordon D. Luk,and Stanley R. Hamilton.

* 6530 Neuronal Cell Differentiation of Human Neuroblastoma Cells byRetinoic Acid plus Herbimycin A. Peter N. Preis, Hideyuki Saya,LászlóNádasdi, Guenther Hochhaus, Victor Levin, andWolfgang Sadée.

6542 Cytoplasmic Accumulation of Ditercalinium in Rat Hepatocytesand Induction of Mitochondrial Damage. Robert Fellous,Dominique Coulaud, ImánEl Abed, Bernard P. Roques, Jean-Bernard Le Pecq, Etienne Delain, and Alain Gouyette.

Tumor Biology

*6262 Blocking of Collagenase Secretion by Estramustine during inVitro Tumor Cell Invasion. Min Wang and Mark E. Stearns.

* 6272 (limai Analysis of Untreated Non-Hodgkin's Lymphoma Utilizing Immunoglobulin Gene Rearrangement and Immunopheno-rype. Richard A. Rudders, Satinder Dhillon, and TheodoreG. Krontiris.

*6379 Proteases in Cyst Fluid from Human Gross Cyst Breast Disease.

Leo Kesner, Wanshang Yu, H. Leon Bradlow, Charles W. Breed,and Martin Fleisher.

* 6384 Modulation of Plasminogen Activator Activity in Human Endo-

metrial AdenocarcinomaCells by Basic Fibroblast Growth Factorand Transforming Growth Factor ß.Marco Presta, Jeanette A. M.Maier, Marco Rusnati, David Moscatelli, and Giovanni Ragnotti.

* 6424 Production of Growth Potentiating Factoids) for Autologous BlastCells by Acute Myeloblastic Leukemia Cells. Ikuo Murohashi,Kaoni Nagata, Toshiya Suzuki, Yoko Yamashita, YasuoMaruyama, and Nobuo Nara.

%6429 Insulin-like Growth Factor 1 Receptors in Human Breast Cancerand Their Relation to Estradiol and Progesterone Receptors. J-P.Peyrat, J. Bonneterre, R. Beuscart, J. Djiane, and A. Démaille.

6438 Autocrine Production of Pre-B-Cell Stimulating Activity by a Variety of Transformed Murine Pre-B-Cell Lines. FrançoisM.Lemoine, Gerald Krystal, R. Keith Humphries, and Connie J.Eaves.

6478 Nuclear Fragmentation and Premature Chromosome Condensation Induced by Heat Shock in S-Phase Chinese Hamster OvaryCells. Michael A. Mackey, William F. Morgan, and William C.Dewey.

6504 Loss of Metastatic and Primary Tumor Factor X Activator Capabilities by Lewis Lung Carcinoma Cells Cultured in VitaminK-dependent Protein Deficient Serum. Michael J. Fasco, GeorgeE. Eagan, Adrian C. Wilson, John F. Gierthy, and David L.Lincoln.

* 65111 Quantitative Studies on the Transplantability of Murine and Human Tumors into the Brain and Subcutaneous Tissues ofNCr/Sed Nude Mice. Anthony L. Zietman, Herman D. Suit,Jonathan R. Ramsay, Vlatko Silobrcic, and Robert S. Sedlacek.

6550 Altered Expression of .\.\t23. a Gene Associated with LowTumor Metastatic Potential, during Adenovirus 2 Eia Inhibitionof Experimental Metastasis. Patricia S. Steeg, GenerosoBevilacqua, Rudy Pozzatti, Lance A. Liotta, and Mark E. Sobel.

* 6573 In Vivo Localization of Human Colon Adenocarcinoma by Monoclonal Antibody Binding to a Highly Expressed Cell Surface Antigen. Hiroshi Takahashi, Byron Wilson, Mehmet Ozturk, PhilippeMotte, William Strauss, Kurt J. Isselbacher, and Jack R. Wands.

Virology

6555 Intervention of T-Cells in Transportation of Mouse MammaryTumor Virus (Milk Factor) to Mammary Gland Cells in Vivo.Airo Tsubura, Muneo Inaba, Shunsuke Imai, Akira Murakami,Naoki Oyaizu, Ryoji Yasumizu, Yoko Ohnishi, HarutakaTanaka, Sotokichi Morii, and Susumu Ikehara.

CLINICAL AND EPIDEMIOLOGICALINVESTIGATIONS

Clinical

6584 Phase I Study of Difluoromethylornithine in Combination withRecombinant a2a-Interferon. John H. Edmonson, John S.Kovach, Jan C. Buckner, Larry K. Kvols, and Richard G. Hahn.

Continued

Research. on August 14, 2021. © 1988 American Association for Cancercancerres.aacrjournals.org Downloaded from

6587 Phase I Trial of Lonidamine with Whole Body Hyperthermia inAdvanced Cancer. H. Ian Robins, Walter L. Longo, Rhonda K.Lagoni, Alan J. Neville, Anders Hugander, C. L. Schmitt, andChuck Riggs.

6593 Phase I Trial of the Amsacrine Analogue 9-(j2-Meth-oxy-4-|(methylsulfonyl)amino|phenyl|amino)-A',5-dimethyl-4-ac-ridinecarboxamide (CI-921). Janet R. Hardy, Vernon J. Harvey,James W. Paxton, Pandora Evans, Shelba Smith, William Grove,Antonio J. Grillo-Lopez, and Bruce C. Baguley.

6597 Appearance and Phenotypic Characterization of Circulating Leu19+ Cells in Cancer Patients Receiving Recombinant Interleukin2. Thomas M. Ellis, Stephen P. Creekmore, John D. McMannis,Donald P. Braun, Jules A. Harris, and Richard I. Fisher.

6603 Relationship of Membrane-bound Tissue Type and UrokinaseType Plasminogen Activators in Human Breast Cancers to Estrogen and Epidermal Growth Factor Receptors. G. K. Needham,S. Nicholson, B. Angus, J. R. Farndon, and A. L. Harris.

6608 Association of DNA Content and Proliferaiin- Activity with Clinical Outcome in Patients with Diffuse Mixed Cell and Large CellNon-Hodgkin's Lymphoma. Terry N. Wooldridge, Helen L.

Grierson, Dennis D. Weisenburger, James O. Armitage, WarrenG. Sanger, Michaeleen M. Collins, Jene L. Pierson, Mary E.Pauza, RenéeFordyce, and David T. Purtilo.

6614 Nucleic Acid Flow Cytometry in Large Cell Lymphoma. PeterMcLaughlin, Barbara M. Osborne, Dennis Johnston, PaulJennings, James J. Butler, Fernando Cabanillas, and BartBarlogie.

Epidemiological

6580 Incidence of Lung Cancer by Histológica!Type from a Population-based Registry. Hoda Anton-Culver, B. Dwight Culver, TomKurosaki, Kathryn E. Osann, and Jason Bok Lee.

6620 AnnouncementsEightieth Annual Meeting of the AACRAACR Special Conferences in Cancer ResearchFuture Annual Meetings of the AACRCollected Perspectives in Cancer ResearchRecent DeathCalendar of Events

6622 Author Index

Applications for active and corresponding membership and for associate membership in the American Association for Cancer Researchavailable in the back of this issue.

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