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Research article structure:
Where can reporting guidelines help?
Iveta Simera
The EQUATOR Network workshop
Research article
• Research article is ‘end product’ of one process …
• …and ‘raw material’ of other processes
2
Design Conduct Publication
Use in further research
Clinical practice guideline
Systematic reviewPublication
Primary research
Informs health policies and clinical practice
Research article: “fit for purpose”
• Published research article is a permanent record
• Will be used by different users for different purposes which means different needs for reporting– From brief scanning for information – To rigorous scrutiny of methodology and findings for possible comparison across
studies in systematic reviews
• Published article should be fit for these multiple purposes
• New ways of publishing (e.g. online suppl) can aid readability without excluding crucial information
3
Typical medical article sections
• Title – attracts readers to the key aspects of the study
• Abstract – summarises the paper and, together with the title, helps reader identify the nature of the
study and briefly summarises what was found
• Introduction – explains why we did the study and what question we asked
• Methods – describes how we did it
• Results – presents what we found
• Discussion – considers what the findings mean
• Conclusions – if present offers a succinct summary of the major findings
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Good research paper
• Is based on carefully designed and well conducted study
• Combines: – Good logical structure
– Complete and accurate description of the key study elements
– Clear and concise writing style
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Good research paper
• Is based on carefully designed and well conducted study
• Combines: – Good logical structure
– Complete and accurate description of the key study elements
– Clear and concise writing style
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Scientific writing guidance
Good research paper
• Is based on carefully designed and well conducted study
• Combines: – Good logical structure
– Complete and accurate description of the key study elements
– Clear and concise writing style
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Reporting guidelines
Scientific writing guidance
Reporting guidelines (RGs)
• Focus on scientific content of the article
• Provide structured advice on what to include in a research report
• Definition:– Specify a minimum set of items required for a clear and
transparent account of what was done and what was found in a research study, reflecting in particular issues that might introduce bias into the research
– Form: often as a checklist (perhaps also a flow diagram)
• Most internationally accepted RGs– Based on evidence– Consensus of relevant stakeholders (multidisciplinary
group)
8Moher et al. PLoS Med 2010
Reporting guidelines database
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Different focus of RG: study design / methodology
• Generally applicable, key methodology features, no details specific to diseases, etc.
• Generic framework for reporting key aspects of:– Main study designs / types (generic guidelines)
• Framework for a complete research paper (examples: CONSORT, STARD, STROBE)
• Framework for only a part of research study / paper (examples: CONSORT for abstracts)
– More specialised designs• Often extending the generic guidelines• Examples: CONSORT for cluster trials
– Specific methods, evaluations, analyses• Generic statistical guidelines• Cost-effectiveness analysis• Quality of life assessment
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Core RG(“Must”)
See your handout: Structure of a medical research paper: key content elements, writing tips, and examples of RG
• Key focus is on discipline / clinical area specific issues – Different ‘degree’ of specificity
• May or may not address general methodology items
• May focus on a complete research study / paper or only on a part
• Examples– RCTs in leukaemia; longitudinal studies in
rheumatology– Economic evaluations in obstetrics
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Different focus of RG: specific discipline / clinical area
Should be used with relevant generic methodology guidelines as they often focus only on content specifics
See your handout: Structure of a medical research paper: key content elements, writing tips, and examples of RG
Medical research paper (1)
12See your handout: Structure of a medical research paper: key content elements, writing tips, and examples of RG
Medical research paper (2)
13See your handout: Structure of a medical research paper: key content elements, writing tips, and examples of RG
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Common problems in research reporting
– Non-reporting or delayed reporting of whole studies– Omissions or misinterpretation of results in abstracts
– Omission of crucial information in the description of research methods and interventions
– Inconsistencies between study protocol (or register) and publication
– Incomplete reporting (data cannot be included in SR / MA)– Selective reporting of only some outcomes or analyses – Inadequate reporting of harms– Inadequate statistical reporting– Confusing or misleading presentation (e.g. presenting data &
graphs in confusing or misleading ways - particularly important for presenting benefits and harms)
– General misinterpretation of study findings (spin)
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Responsibilities of researchers / authors
Key principles for responsible research reporting
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• The research being reported should have been conducted in an ethical and
responsible manner and should comply with all relevant legislation.
• Researchers should present their results clearly, honestly, and without fabrication, falsification or inappropriate data manipulation.
• Researchers should strive to describe their methods clearly and unambiguously so that their findings can be confirmed by others.
• Researchers should adhere to publication requirements that submitted work is original, is not plagiarised, and has not been published elsewhere.
• Authors should take collective responsibility for submitted and published work.
• The authorship of research publications should accurately reflect individuals’ contributions to the work and its reporting.
• Funding sources and relevant conflicts of interest should be disclosed.
Reproduced from the International standards for authors of scholarly publications (http://publicationethics.org/international-standards-editors-and-authors)
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How I can improve reporting of my research study
• Find out about reporting requirements early, when planning your research study
• When writing up your research, check the EQUATOR website for any new relevant guidelines to help improve the quality of your manuscript
• Adhere to the relevant reporting guideline(s).
• When not reporting on certain items explain why.
• Remember that reporting guidelines provide a minimum set of items; other details specific to your particular study might be relevant for a clear and complete account of what was done and found (consider in particular items that might have introduced bias into your research).
• It is important to provide enough information to allow your study to be potentially reproducible by others.
• See ‘Steps to consider’ in Simera et al. BMC Medicine 2010,8:24