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Principles of Immunology, Fall ‘18
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BIO 431/531 Principles of Immunology Course Syllabus
Fall 2018
Fridays 8:45 – 11:15 AM 306 Payson Smith
Course Identification Course Title: Principles of Immunology Credit Hours: 3 CRN# 25780/26726 Class: BIO 431/531
Required Textbook The Immune System, 4th Edition, (2015) by Parham, P. Garland Science, NY. ISBN: 978-0-8153-4466-7. See also Garland Science Immunology Videos
Instructor Contact Information Instructor Name: Blake Whitaker, PhD Office: Lewiston Campus 208B Office Phone #: 753-6535Email address: [email protected]
Office Hours By appointment after class
Catalog Description An introduction to the fundamentals of immunology, especially as they relate to human diseases. Topics include history of immunology, basic elements of immune systems, principles of natural and acquired immunity, cellular and molecular basis of B cell and T cell development and diversity, and clinical aspects of immunology. Prerequisites: CHY 107 or CHY 115, junior standing, and grade of C- or higher in either BIO 107 or BIO 113; or permission of instructor. Cr 3.
Course Objectives/Outcomes To develop in each student a beginning understanding of the human immune system and its
organization To develop a practical understanding of the immune system’s contributions to maintaining
homeostasis To review the molecular underpinnings of immunobiology including antigen recognition
and presentation, receptor-ligand signaling cascades. and genetics To explore the initiation’ development, and control of T and B lymphocyte responses to
antigens To identify, differentiate, and describe various aspects of clinical immunology
DRAFT
Copyright 2018 Blake Whitaker, PhD
Principles of Immunology, Fall ‘18
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How to succeed The course material is interesting, challenging, and requires all of us to work hard. The following are some common sense suggestions made to support your course performance-
1. Come to class, attendance is mandatory. The lectures will clarify the reading andexpand upon it. Reading the material ahead of time and then hearing about it will alsoincrease the retention of the material.
2. Read the material for the class ahead of time. Keep ahead on the reading. This isextremely important. Because of the tremendous amount of material, it is almostimpossible to catch up once you have fallen behind. This is especially true in thesummer sessions.
3. Ask questions in class. It is very likely that you are not the only one having difficultywith the concept or principle in question and you will be doing others a favor by askingthe question. Asking and answering questions also helps develop skills with theterminology that you will be learning and gives you a chance to express yourself usingthat terminology.
4. If you have a problem with the material, ask for help immediately. We can go over the problem immediately or make an appointment to go over it.
5. Form study groups which can meet in person or electronically. The hardest thing toknow is what you don’t know. Support one another and learn how to work effectively inteams. Teamwork is required in nursing, medicine, and science.
Assignments/Grading Final grades will be determined by summing the scores on
1. Three essay exams each worth 30% of the final grade.a. There are no makeup exams except for very good reasons.b. Exams will include definitions, essay questions, and multiple choice
questions.c. Each exam will be graded on a 100 point scale and include 110 points of
assessments, i.e. there will be 10 bonus points on each exam 2. Class participation/chapter questions will account for the remainder of the
grade3. Students enrolled in BIO 531 will be required to:
a. Answer a “Grad Student Question” on each examb. Prepare and submit a 10 page literature research paper using the APA
format (Due December 7, 2018), andc. Present the topic of the research paper in class during a 10 minute oral
presentation followed by a 5 minute question period
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Copyright 2018 Blake Whitaker, PhD
Principles of Immunology, Fall ‘18
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Lecture Topics & Reading Assignments
Class/Date Topic Reading Assignment 1/Sep 7 Elements of the Immune System
Innate Immunity: Immediate Responses Parham, pp. 1- 46
2/Sep 14 Innate Immunity: Induced Responses Antibody Structure & B-Cell GoD
Parham, pp. 47 - 112
3/Sep 21 Antigen Recognition by T Lymphocytes Development of B Lymphocytes
Parham, pp. 113 - 176
4/Sep 28 Development of T Lymphocytes Review1
Parham, pp. 177 – 198
5/Oct 5 Exam #1 – System Components T Cell-Mediated Immunity Parham, pp. 199 - 230
6/Oct 12 Immunity Mediated by B Cells & Ab Parham, pp. 231 - 266 7/Oct 19 Defense of Mucosal Surfaces Parham, pp. 267 - 294 8/Oct 26 Immunological Memory & Vaccination Parham, pp. 295 - 328 9/Nov 2 Coevolution of Innate & Adaptive IR
Review Parham, pp. 329 - 364
10/Nov 9 Exam #2 – System Responses Failures of Body Defenses Parham, pp. 365 - 400
11/Nov 16 IgE-Mediated Immunity & Allergy Grad Student Presentations 1 & 2
Parham, pp. 401 - 432
12/Nov 30 Transplantation of Tissues & Organs Grad Student Presentations 3 & 4
Parham, pp. 433 - 472
13/ Dec 7 Disruption of Healthy Tissue Grad Student Presentation 5
Parham, pp. 473 - 508
14/Dec 14 Cancer and the Immune System Parham, pp. 509 - 532 15/Dec 21 Exam #3 – System Issues Enjoy your semester break!
1 Reviews will depend on your preparation/participation via developed questions. A review is not a repeat of all prior information.
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Copyright 2018 Blake Whitaker, PhD
Principles of Immunology, Fall ‘18
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Blackboard A&P I course content is available on Blackboard. To access this material, go to the LAC website and click “Blackboard” under LAC Quick Links and then select BIO 431/531 Fall 2017.
Attendance Policy Class attendance is critical to the success of the class as a whole and for the individual student. If possible, advance notice of class absence is requested and must be accompanied by a reasonable excuse. Excessive absences or tardiness will result in forfeiture of 2% of the total grading points per unexcused instance.
Cell Phones and Other Distractions Use of electronic devices for class purposes is allowed. However, cell phone ringers and all other potentially disruptive notifications, including vibrations, must be silenced.
Disability AccommodationsThe syllabus should include information for those students having difficulty in a class orneeding accommodations due to a disability. For example:
At any point in the semester, if you encounter difficulty with the course or feel that you could be performing at a higher level, consult with me. Students experience difficulty in courses for a variety of reasons. The following resources are available on campus for student:
Please feel free to drop by The Learning Commons in Portland or Gorham, or theWriting Center at Lewiston-Auburn College. If there is a tutor available, he or she willbe happy to work with you. It is always best, though, to plan ahead and schedule anappointment in advance. This is especially true toward the end of the semester.
If you are familiar with how to schedule an appointment, click HERE to begin. If youare not sure how to use the scheduling system, or if you would like to see how to request an online tutoring session, please see below.
Through partnerships with academic departments at USM, we are able to offertutoring in multiple subject areas at the Learning Commons. We are a peer supportservice, meaning that all of our tutors are current USM students.
Students are allowed two appointments per week per subject area. For example, astudent can schedule two writing appointments as well as two math appointments. There are also some drop-in groups, which do not count towards the two appointments in that subject.
Appointments are available in Gorham, Portland, LAC, and online.
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Copyright 2018 Blake Whitaker, PhD
Principles of Immunology, Fall ‘18
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If you need course accommodations because of a disability, please contact the Disability Services Center in Portland at 780-4706, as soon as possible. For more information, visit http://usm.maine.edu/dsc.
University Health and Counseling Services is a student resource that promotes the health and well-being of the USM community. A personal counselor will be available weekly at LAC; please call Wendy at 753-6685 to make an appointment. More information can be found at www.usm.maine.edu/uhcs.
Academic Integrity Responsible behavior and academic integrity will be expected in this class. Remember honesty is required of all professionals!! Plagiarism, cheating, facilitated academic dishonesty, and falsification of information violates academic integrity. Violation of these policies is subject to penalties up to and including failure for the course.
Plagiarism, cheating, and falsification of information are violations of academic integrity that will not be tolerated in this class. For more information, see http://usm.maine.edu/deanofstudents/student-academic-integrity-policy-0
Campus Safety & Title IX The University of Southern Maine is committed to making our campuses safer places for students. Because of this commitment, and our federal obligations, faculty and other employees are considered mandated reporters when it comes to experiences of interpersonal violence (sexual assault, sexual harassment, dating or domestic violence, and stalking). Disclosures of interpersonal violence must be passed along to the University’s Deputy Title IX Coordinator who can help provide support and academic remedies for students who have been impacted. More information can be found online at http://usm.maine.edu/campus-safety-project or by contacting Sarah E. Holmes at [email protected] or 207-780-5767.
If students want to speak with someone confidentially, the following resources are available on and off campus: University Counseling Services (207-780-4050); 24 Hour Sexual Assault Hotline (1-800-871-7741); 24 Hour Domestic Violence Hotline (1-866-834-4357).
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Copyright 2018 Blake Whitaker, PhD
