REPORT OF lWE RESEARCH FACILITY I Chicago, IL 60612 ...4) The attending veterinarian for this research faality has appropriate authority to ensure the provision of adequate veterinary

ANNUAL REPORT OF RESEARCH FACILITY ( l W E OR PRINT ) I RwhPrebyterian-St Luke's Medicai Ctr

1 653 W. Congress Parkway Chicago, IL 60612

I I Telephone: (31 2) 442-6578

Aninmb Covwed By Tho kJnul

Wethrm Rogubllons

4. Dogs 1 104

B. Non-hurnan Primate

10. Sheep-

12. Other Farm Animals .

N u n b s r d n h p t . w v v t d d r t e e ~ . = m ~ ~ t w g e r y o r ~ w l e r e

-hvdvhO#corrpanylng palnor- lo the enlrralr nd for v&ch the use c4 appropdate anesthetic. anrlgask. or tranquiliring drugs w d d have advbndy afhxted Ihe procedures, dl& or interpretallon d the teaching. research. cspwlmnls. surgery, or lesta ( kb uplandlion of lhe proadves produa'n~ pdn or &tress in these aninrals and the reasons urch drugs were not used m s l be attached to

F.

TOTAL NUMBER OF ANIMALS

( COLUMNS I C + D + E )

1 ASSURANCE STATEMENTS

COLUMN "E" EXPLANATION

1. Registration Number: 33-R-0022

2. Number: 22 of animals used in this study.

3. Species (common name) of animals used in the study. swine

4. Explain the procedure producing pain and/or distress.

Swine are subjected to sterile survival surgery to implant instruments to measure left ventricular and aortic pressures, internal short axis diameter and pulmonary artery flow. Animals receive analgesics - - postoperatively for this procedure. One week after this surgical preparation, swine are subjected to sterile survival surgery to intraperitoneally implant a fibrin clot containing a large number of bacteria, to create a model of sepsis. Swine are then restrained in a metabolic stanchion for four days for close monitoring of the septic condition, for continuous collection of cardiovascular data and to receive treatment or vehicle. Food and water are provided ad libitum while the animals are restrained and all transducer connections are "quick disconnect" in type, so that no harm will come to the animals if rapid movement disconnects instrumentation.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing, see item 6 below.)

It is the IACUCts consensus that these animals are not in pain or distress, as experts on the IACUC have concurred that the septic condition is not painful or distressful in humans. Septic humans are gmerally lethargic and feel "flu-like". For this reason, the IACUC concurred that analgesics, tranquilizers or other anxiety relieving medication are not indicated. However, the IACUC concluded at the same time that the septic condition and restraint in the metabolic stanchion may be stressful and could appear to laypersons to be painful or distressfbl. The IACUC recommended that the principal investigator list the animals used in column "E" of this report. The principal investigator provided a scientific justification for not administering analgesics, indicating that they would interfere with the action and/or reaction of ths swine body to the substance being tested. These animals are made septic to test the efficacy of dmgs for human use, and any pain or distress relieving drugs would interfere with the drug being tested and the cardiovascular parameters being measured to evaluate the effectiveness of the drug. If an animal were to develop conditions unrelated to the study that would indicate the need for any pain or distress relieving drug, the animal is taken off study and treated with these drugs by the veterinarians or is euthanatized.

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e/g/, APHIS, 9 CFR 1 13.102):

Agency CFR

This repot? 6 required by law (7 "SC 2143). Fatlure to report according to the regulations N 0 v 2 2 2002 %attached form for Interagency Report Contrd No.: - additional ~nformation can

L

L rED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

1. CERTIFICATE NUMBER: 33-R-0025

CUSTOMER NUMBER: 584

Abbott Laboratories 100 Abbott Park Rd. Ap13, R403 Abbott Park, IL 60064

FORM APPROVED

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT )

Telephone: (847) -938-8697

). or experimentation. or held for these purposes. Attach additional sheets if necessary ) I -

Si t e 1, 2 2 3 FACIL~~Y LOCATIONS ( sites ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A \

8. Numberof : animals bejng bred. conditioned. or held for use in teaching, testing. experiments. research. or surgery but not ye

34

C. Number of animals upon which teaching. research. experiments. or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

60 7.

D. Number of animals upon which experiments. teaching. research, surgery, or tests were Conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriale anesthetic, analgesic. w tranquilizing drugs would have adversely affected the procedures. results, w


Anlmals Covered By The Animal

Welfare Regulations ( COLUMNS C + D + E )

interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures produang pan w distress in these animals and the reasons such drugs were not used must be anached to

4. Dogs -

5. Cats

6. Gu.inea Pigs

7. Hamsters

8. Rabbits

9. Non-human Primate

10. Sheep

1 1. Pigs

12. Other Farm Animals

Goats 13. Other Animals

Ferrets Gerbil s

I 1) Professionally acceptable standards governing the cam, treatment, and use of animals, indudkg appropriete we of anedetic, analgesic. and banquiliing dmga, prior to, during, and following

actual research. teaching, testing, surgery, or eqwimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the s b d m l s and rsgulations be spedied and qla ined by the principal investigator and approved by the InstiMional Animal Care and Use Committee (IACUC). A summary of all such exceptlons Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a Mef explanation of the exceptions, as well as the species and mvnber of animals affected.

4) The attending veterinarian for this research faality has appropriate authority to ensure the provision of adequate veterinary care and to ovenee the adequacy of other aspedr d animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICIAL Chief Executive Officer or Legally Responsible Institutional ORicial )

(AUG 91 )

DATE SIGNED

&&t%+

-& APHIS

Explanation of Animal Totals

Number of animals

Column E, APHIS form 7023 Registration Number 3 3-R-0025

Explanation

Animals used in anti-infective research to test the efficacy of new compounds against human bacterial pathogens. This work directly supported the development of new antibiotic drugs for human use. Distress resulted from the infection process modeling human infection processes. Use of anesthetic, analgesic or tranquilizer drugs was contraindicated to avoid drug interaction and alterations of the whole animals' response to the infectious agent in combination with the test compound.

Studies involved pre-clinical drug safety studies mandated by 2 1 CFR 312.23(a)(8)(ii) and 21 CFR 314.50(d)(2) to determine safety of new pharmaceuticals prior to human trials and eventual approval for human use. FDA requires study design to establish the maximum tolerated dose. This results in demonstrated toxicity and occasional distress, especially in the highdose groups. Use of anesthetic, analgesic or tranquilizer drugs was contraindicated to avoid drug interaction or masking toxicity.

-- - - -- -- - -

Studies involved pre-clinical drug safety studies mandated by 21 CFR 3 12.23(a)(8)(ii) and 21 CFR 3 14SO(d)(2) to determine safety of new pharmaceuticals prior to human trials and eventual approval for human use. FDA requires study design to establish the maximum tolerated dose. This results in demonstrated toxicity and occasional distress, especially in the high-dose groups. Use of anesthetic, analgesic or tranquilizer drugs was contraindicated to avoid drug interaction or masking toxicity.

Studies involved pre-clinical drug safety studies mandated by 21 CFR 312.23(a)(8)(ii) and 21 CFR 3 14.50(d)(2) to determine safety of new pharmaceuticals prior to human trials and eventual approval for human use. FDA requires study design to establish the maximum tolerated dose. This results in demonstrated toxicity and occasional distress, especially in the highdose groups. Use of anesthetic, analgesic or tranquilizer drugs was contraindicated to avoid drug interaction or masking toxicity.

There were no IACUC approved exceptions to Regulations and Standards during this reporting year

additional inforination can

1. CERTlFlCATE NUMBER: 33-R-0028

CUSTOMER NUMBER: 576 I FORM APPROVED UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

G. 0. Searle & Co., Inc. 4901 Searle Parkway Skokie, lL 60077 T e l : -. 847- 982-7000 Telephone: -- ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT )

1, or experimentation. or held for these purposes. Attach additional sheets if necessary )

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A )

Number of animals E. Number of animals upon which teaching. experiments. research. surgery or tests were conduded involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching, research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

anirnals being bred, conditioned. or held for use in teaching. testing. experiments. research. or surgery but not ye

- 0-

animals upon which teaching. research. experiments, or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

233

-0-

upon which experiments. teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a


Animals Covered By The Animal


4. Dogs

5. Cats

6. Guinea Pigs

I . Hamsters

8. P3bbits

d. Non-human Primate

10. Cheep

11. Pigs


13. Other Animals

1 AssURANCE STATEMENTS

1) ~ i iess iona l l~ s a b l e standards governing the care, treatment, and we of animals. induding appropriate use of anestetic, analgesic, and tranquiling drugs, prior to, during, and following actual research, teaching, testing, surgery, or experimentation were followed by this msm& facility.

2) Each principal investigator has considered alternatives to painful prooedures.

3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be s-ed and explained by the pfindpal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual repoh In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the axceptions, as well as the species and mnbw of animals afeded.

4) The attending veterinarian for this research facility has appropriate auVlonty to ensure the provision of adequate veterinary care and to avsnee the adequacy of other aspect?, of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFlCtAL hief Executive Officer or Legally Responsible Institutional Official )

( AUG 91 )

DATE SIGNED

6 APHIS FORM 7023 (Replaces VS FORM 18-23

(OCT 88). which is obsolete.

Special Use:

Column E Explanation

This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names, addresses. protocols, veterinary care programs, and the like. are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.


2. Number 5 of animals used in this study.

;3. Species (common name) Dogs of animals used in the study.

.4. Explain the orocedure producing pain and/or distress.

= _ Dogs received high dose of test compound. Following dosing, one dog died acutely and four dogs became moribund.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing. see Item 6 below)

This study was conducted to determine non-toxic effective doses of test compound. Use of drugs to reverse the clinical signs that developed would have interferred with the evaluation of the lesions induced by the test compound. The four dogs that were found moribund were euthanized. Necropsies were performed on all five dogs.

6 . What. if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations : (CFR) title number and the specific section number (e.g.. APHIS, 9 CFR 113.102):

Agency CFR

Special Use:


.This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is 'voluntary. Names, addresses, protocols. veterinary care programs, and the like. are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.

1 . Registration Number: 33-R-0028

.2. Number 6 of animals used in this study.

3. Species (common name) Guinea Pig of animals used in tbe study.

4. Explain the orocedure producing pain andfor distress. Six guinea pigs were dosed with a positive control compound that caused

,,, reduction in food consumption and significant weight loss.

:5. Provide scientific justification why pain andor distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

This study was conducted to compare effect of new test compound to effects pf positive control compound. Administration of drugs to reverse the clinical effects would have interferred with the comparison. All animals were euthanized within four days after side-effects were noted. Animals were monitored daily by research.personne1 and animal care staff during

1 the interim period. 'I

i6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations ; (CFR) title number and the specific section number (e-g., APHIS, 9 CFR l13.102):

i Agency CFR

Special Use:


This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.



13. Species (common name) Non-human P r w f animals used in the study.

4. Explain the orocedure producing pain andlor distress. Animal was dosed with test compound and subsequently developed lethargyfor

- - _ twenty minutes.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing. see Item 6 below)

Use of drugs to reverse the clinical signs would have interferred in the evaluation of the effectiveness of the test compound. The animal's vital signs were monitored closely during the twenty minute period during which lethargy was exhibited. The animal spontaneously recovered and all vital signs returned to nornial and futher treatment was not required.

.

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 113.102):

Special Use:


-This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is :voluntary. Names, addresses. protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientist


2. Number 2 . of animals used in this study.

3. Species (common name)N~n-human Primate of animals used in the study.

4. Explain the orocedure producing pain and/or distress. Two non-human primates were dosed orally with test compound.

- One animal coughed up test compound and aspirated a portion of the dose into its lungs and experienced acute death. The other animal developed an acute episode c hypotension post-dosing and died acutely.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used t( determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing. see Item 6 below)

Both non-human primates died acutely post-dosing before medical intervention cou be initiated.

6 . What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations : (CFR) title number and the specific section number (e-g.. APHIS, 9 CFR 113.102):

: Agency CFR

This repM IS requi-d by law (7 USC 2113). Fallure to report according to the rqulations N 0 Y 2 7 2002 attached fm for Interagency Report Control No.: can add~tional information

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I 1. CERTIFICATE NUMBER: 33-R-0029

CUSTOMER NUMBER: 603 I FORM APPROVED

University Of Illinois At Urbana-Champaign 1 Observatory Building 901 S. Mathews Urbana, lL 61801


I Telephone: (21 7) -333-2564

. REPORTING FAClLFPl ( bst all locations where animals were housed or used in actual research. testing. or experimentation, or held for these purposes. Attach additional sheets if necessary )

FAClLrrY LOCATIONS ( Sites ) - See Atached Listing

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1

B. Nurnber of animals being - bred. conditioned. or held for use in teaching, testing, experiments, research. or surgery but not ye

Number of Number of animals E. Number of animals upon which teaching, animals upon which teaching. research, experiments, or tests were conducted involwng no pain, distress. or use of pain- relieving drugs.

upon which experiments. teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

77

experiments, research, surgery or tests were conducted involving acconpanying pain or distress TOTAL NUMBER

OF ANIMALS Animals Covered

By The Animal Welfare Regulations

to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

( COLUMNS C + D + E )

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep

11. Piqs


Bovine 13. Other Animals

Chinchilla

Gerbil

Caprine I ASSURANCESTATEMENTS

I 1) Professionally acceptable standards governing the cam, treatment and use of animals, induding appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during. 8nd following

actual research, teaching, testing, surgery, or experimentation wen, followed by this research facility.

2) Each principal.investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exteptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (kCUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to enurn, the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

2

CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL xecutive Officer or Legalty Responsible Institutional Official )

APHIS FORM S obsolete.

(AUG91 )

DATE SIGNED

11/26/0

SIGNATURE Pnnt

Th~s report IS requlred by law (7 USC 2143) Fallore lo report accord~ng l o the regulallons can NOV 2 7 2002

See reverse sue lor Interagency Report Control No result In an order l o cease and des~st and lo be sublecl lo pen~ l l les Js provlded lor In Secl~on 2150 Md~l lona l ~nlormatlon. 01 80-A-AN

L

t HEADOUARTERS RESEARCH FAClUM (Name end Address. as regrstered wrth USOA

UNITED STATES DEPAfZlMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTlON SERVICE

w

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILrrV (Attach aditlmonal sheets r l necessary or use thjs form.)

1. REGISTRATION NO.

33-R-0029

CONTINUATION SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT)

FORM APPROVED OMB NO. 0579-0036

include Zip Code)

I A

Antmals Covered By The An~mal

Welfare Regulations

------------------I

12. &OR 13. Other (Lst by species)

-

Equine

Bat

- --

1) Prolesstonally acceptable stindards governlng the care. treatment. and use ot aoltnals. ~ncludtng apprortate use of ~clesthet~c. analges~c. and t r ~ r t qu~ l~z l ng <:rugs. prtor to. Ju:llrg. and lollow~ny acturl research. tcach~ng. lestlng. sulgery. or erperlmenlotlocl were followeJ by Ihts research lac~ltty

a Number 01 antmals betng bed. cond~l~oned. or held l o r use ~n teaching. testing, expmrnents. research. w Surgery but not yet used tor such Purpo-.

Ferret

W i l d R o d e n t

-

ASSURANCE STATEMENTS

2). Each pr inc~pr l ~nvestlgalor. has considered alternatives l o pamlul procedures.

32

3). Th~s lacility IS adhering to the slarldards a d regulations under the Act. and 11 has required that eacepttons to the standards and regulat~ons be cpeclfred and rxplamed by the prtnctpol investogalor and approved by Ih r h t ~ t l t ~ l l o l l ~ ~ h t r n a l Care Jrld Use Colnmlltee (IACUC). A summary of all such exceptions i s a l l s chcd l o t h ~ s annual repor t Irt addition to ldenltfy~ng the IACUC.~pproved erceptlons. ihls runlmary includes a buel explanal~on of the exceptlens. as well as the spec~es ~ n d nurnbic 01 animals allecled

C Number 01 an~mals upon which leaching, research. e*wrlments. Or

tests were conducted 1nvoIvtng no Pam. d~stress, or use 01 pan- relieving drugs.

8

I

I

4). The atlending veterinart~n tor t h ~ s research lacilily has appropriate author~ly 10 ensure the provlshon of adequate veterutwy care and l o oversee the adequacy of other irSPeC!S 01 an~mal care and use.

29

75

CEHTIFICATION BY fIEADQUAKTES HESEAHCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional Official)

I cert~ly lhdt the above IS true. correct. r n d cornplele (7 U S C Stc t~on 2143) . SIGNANRE OF C.E-0. OR INSTITUTIONAL OFFICIAL NAME & TITLE OF CEO. OR INSTITUTIONAL OFFICIAL Pype or Prrr~O DATE SIGNED

0. ~~~b~~ ol upon whlch axpertmenls. Ieachmg. research. surgery, or tests were conducted involv~ng accompanymg pain or distress l o the an~mals and lor wh& approprwle

or Iranqu,l,zmg drugs were m.

61

75

63

I

APHIS FORM 70% (AUG 91 )

E. Number ot an~mals upon which leach~ng. uperlments. research. surgery or tests were conducted involnng accompanymg pain or distress to the an~mals and tor wh~ch the use of appropriate anesthetic, analgesic. or tranquiliz~ng drugs would have advusety atftcted the procedures. results. or interpretation o l the teachtng. research. mwrimenfs. surgery. or tests. (An eaplanotion of the Drocedores producing pain or distress in these animals and the reasons such drugs were not used must b. attached lo this report).

--

20

PAKT 1 - HEADQUARTERS

F

TOTAL NO. OF ANIMALS

(~01s. c + D + E)

71

20





3. Species (common name) Guinea Piqs of animals used in the study. .- . - -


Guinea pigs are used for the Anopheles and Aedes species. A monthly blood loss estimate would be 0.12 to 0.5 milliliters of blood per pig per four weeks. Guinea pigs do not appear to show any negative response to our handling and do not appear "frightened" by transport in the holding cages. There is no apparent learned response to our process that would indicate any abnormal stress, nor has there been any loss of guinea pigs due to any factor relating to being used as mosquito hosts. Each guinea pig is only used two times each month.

5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

No other option

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 113.102):

Agency CFR





3. Species (common name) Rabbit of animals used in the study.


We will generate antibodies using rabbits. Healthy New Zealand White rabbits will be immunized with 100-500 mg of bacterially produced protein in Freunds Complete Adjuvant (1 ml volume). The immunization will be given in 10 volumes of 0.1 ml each. The back of the rabbit will be shaved and disinfected. The 10 immunizations will be given at sites more than 4 cm apart and will be given subcutaneously. The rabbits will be boosted in one month with protein and Freunds incomplete adjuvant, in the same manner as the initial immunization. From 10-14 days after the boost, serum will be collected. First, a small volume of test serum will be collected (5 ml). If the titer is good, a larger volume will be collected. Up to I% of the rabbits body weight will be collected (usually about 30 ml). Blood will be collected by catheterizing the central ear artery. After collecting the blood, manual pressure will be applied to the ear for at least 2 minutes to stop the bleeding. The rabbits will be monitored for at least 15 minutes afterward to be certain that the bleeding has stopped. Blood samples will be taken no more frequently than once every 2 weeks

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

Usually pain is minimal in this procedure. If a rabbit becomes unthrifty, we will measure it's hematocrit. If i t is anemic, we will stop blood collection until i t has a normal hematocrit. Staff veterinarians will be consulted in this situation. We do not anticipate other complications but if necessary, we will administer analgesics in consultation with staff veterinarians.


Agency CFR





3. Species (common name) Pigs of animals used in the study.

- 4. Explain the procedure producing pain and/or distress.

Pigs were inoculated with PRRSV.

. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

The purpose of the study was to investigate how the immune system responds to PRRSV and decreases growth. Interfering with what occurs normally after the inoculation would interfere with the study's results.

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 1 l3.102):

Agency CFR


This form is intended as an aid to completing the Column E explanation. It is not an official form - and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.



3. Species (common name) Pias of animals used in the study.

4. Explain the procedure producing pain andlor distress. .. -.

The animals were sbved so that they could be bled. The pain or distress is minimal.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

Not enough pain or distress was inflicted on the animal to justify the use of a tranquilizer or pain medication. The animals eat normal as soon as they are released. The use of medication would produce an effect long after the animal would recover from sbvings on its own. a

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 1 1 3.1 02):





3. Species (common name) Bovine of animals used in the study.

4. Explain the procedure producing pain andlor distress. - z

Induction of colifon mastitis in each of 2 mammary glands (1 control, 1 treatment wlsystemic antibiotic). All cows developed transient swelling of the mammary gland and tachycardia, but feed intake and attitude remained good.

5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

The analgesics would have impacted our measurement of the inflammatory response to coliform mastitis and the cows' systemic response to the local rnastitis (eg, we needed to measure heart rate, CBC, duration of gland swelling, etc.) Justification was provided in more detail in the animal use protocol.

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 1 13.102):

Agency CFR





3. Species (common name) Gerbil of animals used in the study. -

.- -- 4. Explain the procedure producing pain and/or distress.

Gerbils are fed feed that has been contaminated with Neospora oocyst. (no pain from this). Gerbils are then monitored daily for any evidence of illness (e.g. ruffled fur). At first sign of illness, they are euthanized. Any suffering is minimal

+ 5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means

used to determine that pain and/or distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

Most gerbils do not show any evidence of illness. We could not recognize illness (and provide prompt euthanasia), and then recover Neospora from the sick gerbils, if the signs were masked by drugs.


Agency CFR





3. Species (common name) Gerbil of animals used in the study.

--- -_ 4. Explain the procedure producing pain and/or distress.

Gerbils are fed feed that has been contaminated with oocysts (no pain from this). Gerbils are then monitored daily for any evidence of illness (e.g. ruffled fur). At first sign of illness, they are euthanized. Any suffering is minimal.

5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

Most gerbils do not show any evidence of illness. We could not recognize illness (and provide prompt euthanasia), and then recover Neospora from the sick gerbils, if the signs were masked by drugs.

6. What, if any, federal regulations require this procedure? Cite the agency, the Code of Federal Regulations (CFR) title number and the specific section number (e-g., APHIS, 9 CFR 113.102):

Agency CFR


This form is intended as an aid to completing the Column E explanation. It is not an oficial form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.



u-, \& 3. Species (common name) mouse of animals used in the study.

4. Explain the procedure producing pain and/or distress. _

Clinical pseudorabies causes discomfort and respiratory disease that can lead to acute infection of the central nervous system and death. Although mice do not experience pain as such in the disease process, the severity of the disease and the acute encelphalitis require that terminal animals be euthanized. The points were animals are considered terminal are extreme respiratory distress, subnormal body temperature or coma.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. ( For Federally mandated testing, see question 6 below)

Drugs cannot be administered because of the unknown effect that they might have on the outcome of the experiments which are aimed at understanding the interaction of the virus with the immune system.


Agency CFR

Th~s renon IS reqoird by law (7 USC 2143). Fadure to report accordtng to the regulations See attached form for lnterasency Re~crt Control NO.: Adit~onal intonnation

1. CERTIFICATE NUMBER: 33-R-0030 I FORM APPROVED

can

UNKED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

University Of Chicago, The 5841 S. Maryland Ave., Mc- 1000

. REPORTING FACtUTY ( List all locations where animals were housed or used in actual research, testing. or experimentatian, or held for VNsC p u m . Attach a d d i t i d sheets if necessary ) 1

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRINT ) Chicago, IL 60637

Telephone: 7 7 3 -702-3004

.IT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if naccssrn, or use APHIS Form 7023A 1 1 6. Number of

animals bang bred. conditioned. or held for use in teadung, testing. erpenments. research, or surgery but not ye

D. Number of animls E. Number of animals upon which teaching. . experiments. research, surgery or tests were conducted involving accorrpanying pain or distress to the animals and for which the use of apprCpfiate anesthetic, analgesic or tranquilizing dm* would have adversely affected the procedures. resuits. cr mterpretation of the leaching, research. eqmments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these anirrrals and me reasons such drugs were not used must be attached to

an~mals upon which teach~ng. research. experiments. or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

0

upon which experiments. teaching. research, surgery. or tests were conducted involwng accompanying pain or distress to the animals and for which appropriate anesthetic, a

TOTAL NUMBE? OF ANIMALS

Animals Covered By Tho Animal


4. Dogs - --

5. Cats - - -

6. Guinea Pigs

7. Hamsters

8. Rabbits - - -


10. Sheep

11. Pigs

12. Other farm Animals

13. Other Animals -- -

c h i n c h i l l a s

f e r r e t s

g e r b i l s 1 ASSURANCE STATEMENTS I

1) MsrionaHy acceptable standards governing the cars. treatment, and use of animals, inducting appropriate use of anestetic. analgesic. and tranquiliring drugs, prior to, during, yrd tollwing J

actual re- teaching. testing. surgery, or experimentation were followed by this research facility.


3) This facrlity is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations b -tied and explained by the pnncpal ~nvestigator and approved by Vle Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In additicn !o ;dmlifytng the lACUC-appovsd exceptions, th~s summary includes a brid explanation of the exceptions, as well as the specks and nwnber d animals Mected.

4) T h m attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary cars and to oversea the adequacy of other aspSC.s of animal cars and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Oftidal )

SIGNATURE OF C.E

i APHIS FORM 7023 1


This form intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as Part of an . explanation. A Column E explanation must be written so as to be understood by lay Penons as well as scientists.

1. Registration Number: 3 3-R-0030


3. Species (common name) rabbit of animals used in the study.

4. Explain the procedure producing pain andlor distress. This study examines the effects on cardiac muscle cellsc+aused by the pressure

. _ and-volume overload associated with heart failure. These conditions are induced by two surgical procedures. Analgesics and post-operative care are provided, but some animals may experience distress from the symptoms of heart failure. These may include dyspnea, lethergy, or edema. Animals that develop complications resulting in signs of excessive heart failure or respiratory distress are euthanized. The study is routinely terminated after 29 days if there are no complications.

5. Provide scientific justification why pain andlor distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing. see Item 6 below) Since the study depends on inducing symptoms of heart failure, relief of symptoms would negate the goals of the study. The investigator has determined through a search of the literature that no suitable alternatives exist. No cardiac celtline exists that could be used and a computer-based simulated study would not show

- the effects on heart muscle cells.

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 11 3.902):

Agency N/A CFR

IACUC-APPROVED EXCEPTIONS AND NUMBERS OF ANIMAL USED FOR USDA-COVERED SPECIES FOR THE PERIOD 10/0 1/0 1 THROUGH 09/30/02

ACUP 70748 USDA Covered Species: Nonhuman Primate Number Used: 1 1

Variance: Water is not provided ad libittim during some parts of the study. Rationale: This study requires rhesus monkeys to be motivated to perform - simple behavioral tasks in anticipation of receiving fluid rewards. Thus fluids are sometimes restricted to the study sessions, where the animals are able to obtain fluids to satiety.

: = This study conforms to the June, 1990 NIH Guidelines for such research. In addition, the physical condition of the animals is closely monitored. They readily adapt to this schedule during active study periods. At other time fluids are provided continuously.

ACUP 70607 USDA-Covered Species: Nonhuman Primate Number Used: 10

Variance: Water is removed from the animals 7-10 hours prior to testing, thus water is not available at all times. Rationale: The experimental design requires the animals to work for a juice reward by following a spot of light visually. Mild thirst increases the animals' interest and is not detrimental. Water is promptly returned following testing and animals are not allowed to become dehydrated.

ACUP 71 127 USDA-Covered Species: Nonhuman Primate Number Used: 4

Variance: Water is not provided ad libirtim during some parts of this study. Rationale: This study requires nonhuman primates to perform simple visual-motor tasks (move a lever to move a cursor) in order to obtain fluid rewards. Thus fluids are sometimes restricted to study sessions, where the animals are able to obtain fluids to satiety. This study confirms to the NIH Animal Care and Use Committee guidelines for such studies. In addition, the physical condition of the animals is closely monitored and additional fluids are provided as needed to meet the normal daily fluid intake of each animal.

Interagency Report Control No N- J See attached form for

additional inforrnabon Thts report IS required by law (7 USC 2143). Fatlure to report accordlng to the regulallons can

L

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE




Tox Monitor Laboratories, Inc. 33 W. Chicago Avenue Oak Park, IL 60302

Telephone: (708) -345-6970

L 3. REPORTING FAClUM ( List all locations where animals were housed w used in actual research, tes I, or experimentation, or held for these purposes. Attach additional sheets if necessary ) I

-- -

FAClLm LOCAVONS ( Sites ) - See Atached Listing

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I - - - -- -- -

C. Number of animals upon Wih teachmg. research. experiments, or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

- - - --

D. Number of animals upon which experiments, teachmg. research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching, experiments. research. surgery w tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. or tranquilizing drugs would have advendy affected the procedures, results, or interpretation of the teaching, research, experiments. surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

B. Numberof animals being -- bred. conditioned, or held for use in teaching. testing, experiments. research, or surgery but not ye



Welfare RegubHons ( COLUMNS C + D + E )

4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits - -


10. Sheep

1 1. Pigs


13. Other Animals


1) Professionally aaepteble standards governing the care, treatment and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual researdr, t-, m, wrgery, or e)pementation wen, followed by this research facility.

2) Each principal investigator has coosidered alternatives to painful procedures.

3) This faality is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specrfied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions. this summary indudes a brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate euthwity to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and +

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICLAL ( Chief Executive Officer or Legally Responsible Institutional Official )

N ICIAL ( Type or Print DATE SIGNED I /,,I f,4 APHIS F RM 16-23 (OCT 88). wh~ch IS obsolete.


mis form is intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols. veterinary care programs, and the like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.

2. Number of animals used in this study

13. Species (common name) zkb 7 of animals used in the study.

:4. Explain the orocedure producing pain and/or distress.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain and/or distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

TWf,J if UL& Fjp / ~ I J c I L ~ ' 646a7 & q T ~ ~ i d

q'q rr~8y. 7za ~ L U E ~ ~ , L , Y . I 7 @ ~ 4 > 4 3 I Q $4 VkW &% C O L L ~ U ' Q ~ A&'/

ewes 1 V&S .

i6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations I (CFR) title number and the specific section number (e-g., APHIS, 9 CFR 113.1 02):

h This report IS required by law (7 USC 2143). Failure to report according to the regulatlonO C ? 2 .$ 2006 See attached form for Interagency Report Control No.:

additional jnformatlon

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVlCE

1. CERTIFICATE NUMBER: 33-R-0097 I FORM APPROVED OM6 NO. 0579-0036

CUSTOMER NUMBER: 569 f i '\&

Carle Foundation Medical Research 61 1 W. Park Street Urbana, lL 61801

I


-

Telephone: (21 7) -383-3036

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. testing. or experimentation, or held for these purposes. Attach additional sheets d necessary )

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A

C. Number of animals upon which teaching. research. experiments, or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

Number of animals upon which experiments, teaching. research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving w a n y i n g pain or distress to the animals and for which the use of appropriate anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching. research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

B. Number of animals being ; bred, conditioned. or held for use in teachtng. testing. experiments. research, or surgery but not ye




4. Dogs

5. Cats

6. Gu'cilea Pigs I 7. Hamsters I 8. Rabbits I 10. Sheep

11. Pigs I 12. Other Farm Animals

13. Other Animals I Black Bears


1) Prof858ionally acceptable standards governing the care, treatment, and use of animals, indudii appropriate use of amsbtic, analgesic, and Wmqulizing drugs, prior to, during, and following adwl meah, teaching, testing, surgery, or -on were followed by this mean31 facility.

2) Each prinapal investigator has considered altemathm to painful procedures.

3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be speafied and explained by the principal investigator and approved by fhe Institutional Animal Care and Use Committee (MCUC). A summty of all such exceptions Is attached to this annual report. In addiiion to identifying the IACUC-epproved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals Mected.

4) The attendinp veten'hrian for this research facility has appropriate authority to ensure the provision of adequate veterinary cam and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlCLAL ( Chief Exeartive Officer or Legally Responsible Institutional Official )

DATE SIGNED

h IS obsolete.

APHIS Form 7023 Site List (per Item 3)

Registration Number: 3343-0097

Facility: Carle Foundation Medical Research 61 1 W. Park Urbana, lL 61801 (21 7) 383-3036

The following site is used to house and conduct research on animals:

Carle Bear Research Facility 2397 County Road 675E Champaign, IL 61821


This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names, addresses, protocols, veterinary care programs, and the like, are not required as pan of an

. explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.


13 2. Number r

of animals used in this study.

Black Bears 3. Species (common name) of animals used in the study.

- .

4. Explain the procedure producing pain andlor distress.

Animals are used to study hibernation which involves fasting during the - months. In the wild, d'uring the natural denning season, black bears

normally do not have access to food or even water, but are able to survive as long as 5 to 7 months under these conditions without eating, drinking, urinating or defecating. In addition, female bears are able to give birth and nurse cubs while maintaining their winter fast. In order to stimulate the metabolic changes in captive black bears, it is necessary to reproduce the denning state as found in the wild. To do this, bears housed at the Carle Foundation Research Facility are fasted for 4-5 months, -

but have free access to water. The bears are observed daily by-the . .

caretaker and once a month by a veterinarian. Anesthesia and medications for pain relief are used for any painful procedures.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing, see Item 6 below)

Not applicable

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g., APHIS, 9 CFR 11 3.1 02):

Agency Not applicable CFR

Thrs repoct IS required by law (7 USC 2143). Fa~lure lo report accordmg to the regulatrons See attached form for Interagency Report Control No.: additional informatron

1


1. CERTIFICATE NUMBER: 3 3-R-0 1 22 I OMB FORM NO. APPROVED 05790036 1 I CUSTOMER NUMBER: 796 I

. REPORTING FAClLrrY ( List all locations where anrrnals were housed or used in actual research. testing. or expenmentation. or held for these purposes. Attach addlbonal sheets tf necessary ) 1

Pfizer, Inc. East Lincoln Road P. 0. Box 221 White Hall, IL 62092


Telephone: (21 7) -374-21 02 I [-REPORT OF A N ~ L S USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv o r use APHIS Form 7023A \ I

B. Numberof animals being bred. condittoned. or held for use in teaching, testing. experiments. research, or surgery but not ye

C. Number of animals upon which teaching. research. experiments. or tests were conducted involnng no pain. distress. or use of pan- relieving drugs.

D. N u h r of animals upon whlch experiments, teaching. research. surgery. or tests were conducted involving accorrpanying pain or distress lo the animals and for *iCh appropriate anesthetic. a

E. N u d m of animals upon whrch leachng. expenmeots, research, surgery or tests were conduded involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching. research, experiments. surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to




4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep

1 1. Pigs


Cattle 13. Other An~rnals

ASSURANCE STATEMENTS L I

1) Professionally aaeptable standards governing the care, treatment and use of animals. including appropriate use of anestetic. analgesic. and tranquilizing drugs, prior to, during, and following adual research, teaching, testing. urgery, or experimentation were followed by this research faali i.

2) Each principal investiptor has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Act, and it has required that excaptions to the standards and regulations be specilied and explained by the principal investigator and approved by the Institulional Anrmal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to t h k annual report. In addition to identrfying the IACUC-approved exceptions. this summary includes a brief explanation of the exceptions, as well as the spedes and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to enswe the provision of adequate velerinary care and to oversee the adequacy of other a-s of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICWL ( Chief Executive Officer or Legally Responsible Institutional Official )

CT 88). which IS obsolete.

DATE SIGNED

Z&Z

Special Use:


This form is intended as an aid to completing the Column E explanation. It is not an official form and its use is voluntary. Names. addresses, protocols, veterinary care programs, and ihe like, are not required as part of an explanation. A Column E explanation must be written so as to be understood by lay persons as well as scientists.


2. Number 1862 of animals used in this study

3. Species (common name) Guinea Pig of animals used in the study.

- 4. Explain the orocedure producing pain andlor distress.

Potency testing requirements for Clostridium chauvoei, and C1. haemolyticum .. require that both vaccinated and non-vaccinated (Control) guinea pigs be

challenged with virulent organisms as proof of the potency of the bacterin. The vaccinates must survive challenge while the controls must die.

5. Provide scientific justification why pain and/or distress could not be relieved. State methods or means used to determine that pain andlor distress relief would interfere with test results. (For Federally mandated testing. see Item 6 below) Anesthetics and/or analgesics may not be used because they might interfere with the results.

6. What, if any, federal regulations require this procedure? Cite the agency, the code of Federal Regulations (CFR) title number and the specific section number (e.g.. APHIS. 9 CFR 113.102):

additional information This report is required by law (7 usc 2143). Failure to report according to the rquQ&J 1 5 2002 See attached form for Interagency Report Control No.: can

1. CERTIFICATE NUMBER: 33-F-000 1 I FORM APPROVED OMB NO. 0579-0036



Naval Dental Research Institute Naval Dental Research lnstitut 310a B Street, Building 1-H Great Lakes, IL 60088

J m

I


3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or expenmentation, or held for these purposes. Attach additional sheets if necessary )

Telephone: (847) -688-4651

FACILITY LOCATIONS ( Sites ) - See Atached Listing

-- -

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY i Attach additional sheets if necessarv o r use APHIS Form 7023A \ 1 6. Number of

animals being bred, conditioned, or held for use in teaching, testing. experiments, research, or surgery but not ye

C. Number of animals upon which teaching. research, experiments, or tests were conducted involving no pain. distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain w distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results. or interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to




5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabb i


10. Sheep

1 1. Pigs

12. Other Farm Animals m 13. Other Animals 0


1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and trenquili drugs, prior to, during, and following actual research, teaching, testing, surgery, or experimentation were followed by this research facili.


3) This fedlity is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the InstiMional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to thit annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the -6s and number of animals affeded.

4) The attending veterinarian for this research facility has appropriate authority to emure the provisicm of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILrrY OFFlClAL ( Chief Executive Oflicer or Legally Responsible Institutional Official )

1 DATE SIGNED

1 --. 4.- 1

(b)(6)

See attached form for additional information

Interagency Report Control No.:


CUSTOMER NUMBER: 8 1 0

Th~s report is required by law (7 USC 2143). Failure to report according to the regulations

I FORM APPROVED OMB NO. 05794036

i

Illinois Wesleyan University P.O. Box 2900 Bloomington, IL 61 702


C l * b p.2 nkA-4 5dZt-a zw GLU~+.L. S+ FACIL~~Y LOCATIONS ( sites ) - See Atached Listing

B)o~r+.rrm+- JL b d f ~ x ' 2 4 ~ b REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessaw or use APHIS Form 7023A 1 3

A

can

Telephone: (309) -556-3255


B. Numberof animals being bred, conditioned, or held for use in teaching. testing. experiments. research, or surgery but not ye

J I

1 I

Number of animals upon which teaching. research, experiments, or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) 1

D. Number of animals upon which experiments, teaching, research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching, experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching, research. experiments, surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

Animals Covered By The Anlmal

Welfare Regulations



4. Dogs I 5. Cats I 6. Guinea Pigs I 7. Hamsters I 8. Rabbits I 9. Non-human Primate I

I

10. Sheep


13. Other Animals


1) Professionally acceptable standards governing the care, treatment, and use of animals, including -ate use of anestetic, analgesic, and trenquilizii drugs, prior to, during, and following adual research, teaching, testing. sweery, or experimentation were followed by this research facility.

2) Each principal investigator has considered alternatives to painful procedwss.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Cam and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affeded.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to owtnee the adequacy of other aspects of animal care and F

FICATION BY HEADQUARTERS RESEARCH FACILIW OFFlClAL f Executive Omcer or Legally Responsible Institutional OffWal)

DATE SIGNED


Interagency Report Control No.: This report is required by law (7 USC 2143). Failure to report according to the regulations can

- -



. I FORM APPROVED OMB NO. 0579-0036


Illinois State University 3330 Academic Research Svcs Normal, IL 61 790


Telephone: (309) -438-2528

I Fekmley Hall Annex Rm 235 Miller Park Zoo FAClLrrY LOCATIONS ( Sites ) - See Atached Listing University Farm

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILllY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 1 B. Numberof

animals being ored. conditioned, or held for use in teaching. testing, experiments. research. or surgery but not ye

C. Number of anirnals upon which teaching. research. experiments. or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the anirnals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or


Animals Cwered By The Animal


interpretation of the teaching, research. experiments. surgery. or tests. ( An explanation of the procedures produdng pain w distress in these animals and the reasons such drugs were not used must be attached to

I

4. Dogs

5. Cats

6. Guinea Pigs I I 7. Hamsters I 8. Rabbits I I 9. Non-human Primate I I 10. Sheep

White Footed idice I 13. Other Animals

Sumatran ~ i g e b I

I

S u n Bears I I ASSURANCE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals. including appropriate we of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual research, teaching, testing, surgery, or experimentation were followed by this research faciiii.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be rpecified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addiion to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptiis, as well as the species and number of animals dfwted.

4) The attending veterinarian for this research facility has appropriate author@ to ensure the provision of adequate veterinary care and to oversee the adequacy d other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

p - --

Thts report IS requtred by law (7 USC 2143) Fatlure to report accordtng to Ihe regulat~ons can result tn an order to cease and destst and to be subtect to penalttes as prov~ded l w In Section 2150.

See reverse sde tor hleragency Report Control No. additbond inlormatton. 01 80-00A-AN

UNWED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTlON SERVICE

1. REGISTRATION NO.

3

CONTlNUATlON SHEET FOR ANNUAL REPORT OF RESEARCH FACILITY

( TYPE OR PRINT) I FORM APPROVED OM0 NO. 0579-0036

I1 1 inois State Universitv 3330 Academic Research Services Normal, IL 61790

2. HEADOUARTERS RESEARCH FAClLlN (Name end Address. as reqstered wrth U D A . include Zip Code)

Honal sheets r l necessarv or use this farm ) I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILIlV M a c h adik , - - - - - . . . . .

D. Number of animals upon E. Number 01 animals upon which teaching. expermmts, research. surgery or tests were

F which axpariments.

A

Animals Covered By The Antmal

Welfare Regulations

------------------. 12. &/OR 13. Other

( h t by species)

C Number ot animals upon whtch teaching. research. exper~ments. or lesls were conducted involv~ng no pan, datress. or use 01 patn- relieving drugs.

8. Number of animals bang bred. conditioned, or held Jor use ~n teachmg, testing. experiments. research, or surgery but not yet used for such Purposes.

- - - - -. teaching, research. surgery, or tests were conducted involving accompanymg pan or dislress to the animals and lor w h r h appropriale anesthelic, analgesic. or tranquilizing drugs were used.

conducted involving accompanymg pain or distress 10 the animals and lor which the use o l appropriate anesthetic, analgesic. or tranquilizing drugs would have adversely attected the procedures. results. or interpretation of the teaching. research. experiments, surgery. or tests. (An explanation d the procedures producing pain or distress in these animak and the reasons such drugs were not used must be attached to this report).


(Cots. C + D + E)

- --

Tortoises - Goats

Bobcats I I ~ e d woiies I j

-Pygmy Marmosets Meerka t s Lemurs I I

I ASSURANCE STATEMENTS

1) Prolessionally acceptable standards governtng the care. treatment, and use of artitnals, including approriate use of aoesthetic. analgesic, and trartqurlizing tfrugs. prtor to. during. and tollowinci) ~ c t u a l rt?seatch. Ieachmg. Irsling, surgery, or experimentat~orr were lollowed by thts research lacrlity.

2). Each principal rnvestigator has considered alternatives lo pattitul procedures.

3). This Iaolity 1s adhering to the standards and regul~ltons under the Act, and it has required lhat exceptions to the standards and regulattons be rpectlied 2nd explatned by the princtpal investigator and approved by the Irbsttlultooal Antma1 Care and Use Cotnrncttee (tACUC). A summary of all such exceptions is a t t jched to this annual report. I r t addition to identify~ng the IACUC-approved excepttons, lhts suntmary Includes a brtel explanation 01 the exceptions. as well as the spectes and rtunher ol anttnals atfecled.

4). The attending veterinarmn lor lhts research tacthty hds approprmte aulhortty to ertsure the prov~stot~ 01 JdequJte vetertttary care and to oversee the adequacy of other aspects o l antmal care and bse.

CERTIFICATION BY 1lEADQUAHTES HESEAHCH FACILITY OFFICl A L (Chief Executive Officer or Legally Responsible Institutional Official)

I certify that the J ~ O V ~ is true. correct. and complete (7 U.S.C. Sectton 21 43)

DATE SIGNED

FACILITY SITES LISTING

LicenseeRegistrant Name: Illinois State University

License/Registration Number: 33-R-0003

Please list below all sites that house regulated animals under the above number. Be sure to include all requested information. If the line does not apply, please note it NlA. If you have more than three (3) sites, copy this form as many times as necessary before filling in the sites.

Site No. 11 NameIDepartment: Felmley Hall Animal Lab

Address: Illinois State University Research and Sponsored Programs Mail Code 3040 Normal, IL 6 1790-3040

Building: Felmley Hall

FloorRoom: 2" Floor, Room 235

Contact Person: -------- -- --------- Phone No: ------- ---------- --

Site No. 02 Namemepartment: ISU Farm

Address: Illinois State University Research and Sponsored Programs Mail Code 3040 Normal, IL 6 1 790-3040

Locat ions: Gregory Street, Normal, IL Lexington, IL

Contact Person: -------- -- --------- Phone No.: ------- ---------- -- .

Site No. - NameDepartment :

Address:

Building:

Floor/Room:

Contact Person: Phone No.:

All redactions on this page are pursuant to (b)(6) & (b)(7)(c).

This report is required by law (7 USC 2143). Failure to report according to the regulations K T 1 6 2002 wawmfomfor can additional information

Interagency Report Contro w UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PLANT HEALTH INSPECTION SERVICE


I I -

1. CERTIFICATE NUMBER: 33-R-0006 FORM APPROVED OMB NO. 0579-0036

CUtTOMER NUMBER: . 594 D I

pvsplna c#b Children S Memorial Institute 2300 Children's Plaza, Me4W I Chicago, IL 60614-3-344 I

I

. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary ) i

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I ~ttacYh additional sheets if necessanr or use APHIS Form 7023A \ 1

Animals Covered ay The Animai

Welfare Regulations

B. Number of animals being - bred, conditioned. or held for use in teaching. testing, experiments, research, or surgery but not ye

4. Dogs I

C. Number of animals upon which teaching. research,

I experiments, or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching, research. surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Nurnbw of animals upon which teaching. experiments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching, research, experiments. surgery. or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

TOTAL NUMBER OF AXMAiS


5. Cats

6. Guinea Pigs

7. Hamsters I I I I I 8. Rabbits


10. Sheep

1 ASSURANCE STATEMENTS 1

11. Pigs


13. Other Animals

Fe fret s

1) Professionally acceptable standards governing the care, treatment. and use of animals, incfuding appropriate use of OneStetic, analgesic, and tranquilizing drugs, prior to, during, and following adual research, teaching, testing, surgery, or experimentation were followed by this research facility.

6b


6b

25

12

3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the lnstiiutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual repoh In addition to identifying the IACUC-appmed exceptions, this summary includes a brief explanation of the exceptions, as wefi as the species and number of animals affected.

25

12

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterirwy cam and to oversee the adequacy of other aspeds of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Official )

SIG (DATE SIGNED

APHI

( AUG 91 )

This report IS required by law (7 USC 2143). Failure to report according to the regulations Interagency Report Contrd No.: r;r n -- -

U N E D STATES DEPARTMENT OF AGRICULTURE AN!WL .Wn PLA.hlT HEN?!-! !MSPEC-T!% SEWC-E


1. CERTlnCATE NUMBER: 33-R-0009


I Telephone: (3 12) -791 -2000

-

FORM APPROVED

. 3. R E P O R ~ N G FAClUTY ( List all locations where animals were housed or used in actual research. testing. or expenmentation, or held for these purposes. Attach additional sheets if necessary )

Michael Reese Hospital & Medical Center Department Of Lab Animal Medicine D-1118 2929 S. Ellis Ave Chicago, IL 60616

FACILITY LOCATIONS ( Sies ) - See ~tached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A \

B. Nurnber of - animals being bred. conditioned. or held for use in teaching. testing. expenments. research, or surgery but not ye

C. Nurnber of animls upon which teaching, research. experiments, or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

D. Number d animals upon which experiments, teaching. research, surgery. w tests were conducted involving accorrganying pain w distress to the animals and for which appropriate anesthetic. a

- - - - - -- - - -- - -

E. N u h e r of animals upon which teaching. experiments. research. surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic. analgesic. or tranquilizing drugs would have adversely affeded the procedures, results. w interpretation of the teaching. research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



Welfare Rzgubtions ( COLUMNS C + D + E )

- -

4. Dogs 2

5. Cats -

7 . Hamsters

8. Rabbits

1 1. Pigs

12. Other Farm Animals I

5


10. Sheep

13. Other Animals

1 4

-


1) Professionally acceptable standards governing the care. treatment, and use d animals, inducting appropriate use of anestetic, analgesic, and tranquilizing drugs. prior to, m, and following a w l research, teaching. testing. surgery, or experimentation were followed by this research facilii.


3) This facility is adhering to h e sianoards and reguiaiions under the Act, and ii has required that exceptions to ihe sandards and reguiaiions be specified and expiained by ihe principai investigator and approved by the Institutional Animal Care and Use C~Inmittee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the LACUC-apprwed exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number d animals affected.

has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspeds of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFlClAL ( Chief Executive Officer or Legalty Responsible Institutional Official )

+ %

(AUG 91 )

S I

r'

APHIS FORM 7023 (Replaces VS FORM 18-23 (OCT 88). whtch IS obsolete.

Pnnt

DATE SIGNED

This report is required by law (7 USC 2143). Failure to report according to the regulations can




OCT 0 7 2002


. REPORTING FACILITY ( List all locations where animals were housed w used in actual research, tesl

Midwestern University 555 31 st Street Downers Grove, IL 60515

Q34' Telephone: @fX# -515-6140



2, or experimentation, or held for these purposes. Attach additional sheets if necessary )

FORM APPROVED OM6 NO. 05740036

I REPORT OF ANIMALS

\ "i'


Welfare Regulations

FAClLlM LOCATIONS ( Sites ) - See Atached Listing

JSED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I B. Nurnberof -

animals being bred, conditioned, or held for use in teaching. testing. experiments. research, or surgery but not ye

4. Dogs I I 5. Cats I I 6. Guinea Pigs I I 7. Hamsters I I 8. Rabbits

- -- ---

9. Non-human Primate I I 10. Sheep 1 I --

11. Pigs I I 12. Other Farm Animals

13. Other Animals I 1 ASSURANCE STATEMENTS

C. Number of animals upon which teaching. research. experiments, or tests were conducted involving no pain, distress. or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments. research. surgery w tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures, results, or intwpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures producing pajn or distress in these anirmls and the reasons such drugs were not used must be attached to



1 ) Professionally acceptable standards governing the care, trsatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilking drugs, prior to, during, and following adual research, teaching, testing, surgery, or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Ad, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to thls annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFlClAL ( Chief Executive Ofker or Legalty Responsible Institutional Official )

DATE SIGNED

Facility Locations

Evanston Hospital Coon Research Building 2650 Ridge Avenue Evanstonl IL 60201

MR Center for Research 1033 University Place, Suite 150 Evanstonl IL 6Q201

This report IS r qu~red by law (7 USC 2143). Fa~lure to report accord~ng to the regulat~ons can

See attached fonn for additional mformation


--

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I I

-- -

1. CERTIFICATE NUMBER: 33-R-0013 FORM APPROVED OM8 NO. 05794036



Evanston Northwestern Healthcare 2650 Ridge Avenue Evanston, lL 60201

Telephone: (847) -570-2000

- -- - - -

I. REPORTING F A C ~ ~ ( List all locations where animals were housed or used in actual research, testing. w experimentation, or held for these purposes. Attach additional sheets if necessary ) I

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessaw or use APHIS Form 7023A 1 1


Welfare Regulations

- --

6. Number of animals bemg bred. conditroned, or held for use In teaching. tesbng. expenrnents, research. or surgery but not yr

5. Cats I

I

6. Guinea Pigs I

4. Dogs

7. Hamsters I

1

C. Numter of animals upon which teachmg. research. expenrnents, or tests were conduc!ed involvmg no pam, distress, or use of pain- relieving drugs.

Number of animals upon which experiments. teaching. research. surgery, or tests were conducted involving accompanymg pam or distress to the animals and for which appropriate anesthetic. a

8. Rabbits

9. Nonhuman Primate

E. Number of animals upon which teaching. experiments, research. surgery or tests were conducted involving accompanying pain or distress to the anirrrals and for which the use of appropriate anesthetic, analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching. research, experiments, surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

22



ASSURANCE STATEMENTS I 1) Professionally acceptable standards governing the care, treatment. and use of Ztnimals. including appropriate use of anestetic, analgesic, and tranquilizing drugs. prior to, during. and following

10. Sheep

11. Piis


13. Other Animals

actual research, teaching, testing. wrgery, or experimentation were followed by thb researth facility.


3) This facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report In addition to identrtying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions. as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the pmvision of adequate veterinary care and to oversee the adequacy of other aspects d animal care and

4

40

40

i

nt

DATE SIGNED

1 4 G 1

1. CERTIFICATE NUMBER: 33-R-0014 FORM APPRO'JED I O U B N C O S 7 S - i ! 5 X

tt 7.

Southern Illinois University Vivarium, Life Science li Room 1062

r UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

b


-

Carbondale, 11 62901

Telephone: (61 8) -536-2346

3. REPORTING FACILITY ( bs l all locations where animals were housed or used In actual research, lesting. or expenmentabon, or held for these purposes. Attach additional sheels if necessary ) J - - - - -

FACILITY LOCATIONS ( Sites ) - See Atached L i n g

-- - - -- - - - - - -

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACIUTY I Attach additional sheets if necessarv or use APHIS Form 7023A )

B. Number of animals being bred. -- conditioned, or held for use in teachlng. testing, experiments, research. or surgery but not yr

C. Number of anlrnals upon which teaching. research, experiments, or tests were conducted involwng no pain, distress, or use of pain- reltevrng drugs.

0

0

D. Number of animals upon which experiments, teaching, research, surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthelic, a

E. Number of animals upon whch teaching. exper~ments, research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriaie aneslhetic, analgesic, or tranquiliang drugs would have adversely affected the procedures, results, Or interpretallon d the teachng, research. experrrnents. surgery, or tests. ( An explanation of the procedures producing pan or drstress In these animals and the reasons such drugs were not used musl be attached 10

F.

TOTAL NUMBEi? OF ANIMALS



Welfare Regulations

4. Dogs + 5. Cats I 6. Guinea Pigs I

I

7. Hamsters

8. Rabbits I 9. Non-human Primate

10. Sheep I 1 1. Pigs

- 1 12. Other Farm Animals I

Horses I 13. Other Animals I

Catt le I Beaver

Deer ASSURANCE STATEMENTS

1) Professionally acceptable standards governing the care, treatment, and use of animals, induding appropriate use d anesletic, analgesic, and tranquilizing drugs, prior to, durino, and f o l l h n ~ actual research, teaching, lesting, surgery, or experimentation were followed by this research facility.

2) Eech principal investigator has considered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the Ad, and it has required thal exceptions to the standafds and regulations be specirred and explained by the principal investigator and approved by tha Institutional Anlrnal Care end Use Committee (IACUC). A summary of a# such exceptions Is attached to this annual report. In addition to identifying the IACUC-epproved exceptions, this summary includes a brief exqlanation of the exceptions. as well as the species and number of animels affeded.

4) The attending velerinerian for this research facility has appropriale authority to ensure the provision of adequate veterinary care end to oversee the adequacy of other asp& of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrCY OFFlClAL ( Chief Executive Omcer or Legally Responsible Institutional Official )

DATE SIGNED

w

Site(s) Listing

Registrant Name: Southern Illinois University

Certificate No.: 33-R-0014

Site No.: 001

Life Science I I - main campus Life Science Ill - main campus WiMlife Annex - McLafferty Road Beef Center - Rowden Road Beef Evaluation Station - Union Hill Road Dairy Center Annex - McLafferty Road Dairy Galf Facility - McLafferty Road Dairy Center - McLafferty Road Horse Center - Union Hill Road Metabolism Physiology Laboratory - Union Hill Road Swine Center - Union Hill Road

This report is required by law (7 USC 2143). Failure to nport according to the regulations See attached f m for htewlenc~ Report can additimal infomation

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND P L M HEALTH INSPECTION SERVICE I 1. CERTIFICATE NUMBER: 33-R-0023

CUSTOMER NUMBER: 595 I FORM APPROVED OMB NO. 05190036

ANNUAL REPORT OF RESEARCH FACILITY ( TVPE OR PRIM ) I

Baxter Healthcare Corporation Baxter Technology P W g 2 Route 120 & Wilson Road Round Lake, IL 60073

I Telephone: (847) -270-5455

I I. REPORTING FACtlCrV ( List all locatiw where animals were housed or used in actual reseanh. testing, or apubmtation, or hdd fur these purpoxs. Attach add i t id sheets if n a e s a y )

1 REPORT OF ANtMALS

4. Dogs

JSED BY OR UNDER

B. Fhrmberof animals being' bred. conditioned. or held for use in -n& testing. Wments. research. or surgery but not ye

FACIIJ'W LOCATIONS ( Silsr ) - Seh ~tached Usting

:ONlROL OF RESEARCH FACnTTY 1 Attach additkn;rl shaeb H necessa~ or use APHIS Fonn 70234 \

C. Nurrbefd aninralsupon wrhich teaching. -. testSwel-0 Conduded M n g no pain. distress. or use of pain- relieving drugs.

13

E. d a n i ~ upon whict~ teading, ocperimenknsearch,swgeryort~were conducted involving accompanying pain a distxes lo the animals and for which the use of appropriate aneshk analgesic, or tranquilizing drugs warM h a v e ~ a f f e c t e d t h e p r o a d w e s . ~ , o r interpretation d the teaching. nseanh. expefimcnts. surgery, or tesk ( An ocpbnation of the proadures produdng pain or distress in these animals and the reasons such Qugs were not used must be attached to

TOTAL NUMBER Of ANIMALS


5. Cab

CERTIFWTlON BY HEADQUARTERS RESEARCH FACIUTY OFFICIAL

10. sheep

11. Piis

12 Other Farm A n i i

1 3. Other Animals

DATE SIGNED

L0/22/02

- - -

17

22

- ppppp - -

17

22

Z

Thls report is requtred by law (7 USC 21431 Fatlure to report according to the regulations can See reverse slde for result tn an order to cease and desist and to be Subject to penalttes as provtded for n Sectton 21 50 additional tnforrnation

Interagency Report Control NO 01 80-00A-AN


3. REPORTING FACILITY (List all locations where antmals were housed or used in actual research. testing, teaching, or experimentatton, or held for these purposes. Attach addtttonal sheets tf necessarv I

ANNUAL REPORT OF RESEARCH FACILITY (TYPE OR PRINT)

FACILITY LOCAllONSfsites)

1. REGISTRATION NO. CUSTOMER NO. 33-R-0024 583

I

2 HEADQUARTERS RESEARCH FACILITY (Name and Address, as regrstered wth USDA, indude Zip Code)

LOYOLA UNIVERSITY 21 60 S. FIRST AVE. MAYWOOD, IL 60153

STRITCH SCHOOL OF MEDICINE I

FORM APPROVED OM8 NO. 0579-0036

r

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach additional sheets if necessary or use APHIS FORM 7023A )

animals being Animals Covered

By The Animal conditioned, or Welfare Regulations held for use in

teaching, testing, experiments.

C. Number of animals upon which teachtng, research. experiments, or tests were Conducted

0. Number of animals upon E. Number of antmals upon whtch teaching. F. which experiments. expertments, research, surgery or tests were teaching, research. conducted involv~ng accompanying pain or distress TOTAL NO surgery, or tests were to the animals and for which the use of appropriate OF ANIMALS conducted involving anesthettc.analgesic. or tranquiliz~ng drugs would accompanying pain or have adversely affeded the procedures. results, or (Cols. C + distress to the animals interpretation of the teaching. research, D+E)

research. or involvtng no and for which appropriate experiments, surgery, or tests. (An explanatron of surgery but not pain, distress. or anesthetic, analgesic, or the procedures producrng parn or drstress in these

. - yet used for such use of paln- tranquilizing drugs were animals and the reasons such drugs were not used purposes. relieving drugs. used. must be artached to this repoft!

4. Dogs 17 46 46

5. Cats 2 99 99

5. Guinea Pigs I 18 18

7. Hamsters I I 143 143

3. Rabbits 18 25 1 73 324 I 3. Non-Human Primates I 17 I 17

10. Sheep 1 I 1 I 1 I 1. Pigs 20 20


3 . Other Animals

SSURANCE STATEMENTS

1) Professionally acceptable standards governing the care. treatment, and use of animals, including appropriate wa of anesthetic, analgesic. and tranquilizing drugs. prior to, during. and following actual research. teachtng, testing. surgery, or experimentation were followed by this research facility.


3 ) Thts facility is adhering to the standards and regulations under the Ad. and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all the exceptions is attached to this annual repoh In addition to identtfying the IACUC-approved exceptions, th~s summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for thts research factl~ty has approprtate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other asoects of antrnal care and use

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible lnstitutional official)

I certify that the above is true. correct, and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) DATE SIGNED

L I

APHIS FORM 7023 (Replaces VS FORM 18-23 (Oct 88), which is obsolete PART 1 - HEADQUARTERS (AUG 91)

APHIS Form 7023 Additional Reported Sites

The following additional sites have been reported by the facility. The reported sites have not been verified by APHIS and have been provided by the facility solely for completeness of the APHIS Form 7023 Annual Reporting submission.

Registration Number: 33-R-0024 Customer Number: 583 Facility: LOYOLA UNIVERSITY

2160 S. FIRST AVE. MAYWOOO, IL 60153

University of lllinois/Biological Resources Laboratory 1840 W. Taylor Street Chicago, IL 60612 (nothing housed at this site during this reporting period) Edward Hines Jr. Veterans Hospital 5th Avenue & Roosevelt Road Hines, 1L 60141 (hamsters and dogs hdused at this site)

Thts repon is required by law (7 USC 2143). Fallure to report according to the regulations See attached form for 9 C ? 2 2002 additional informatiin can

UNITED STATES DEPARTMENT OF AGRICULTURE 1. CERTIFICATE NUMBER: 33-R-0027 FORM APPROVED ANIMAL AND PLANT HEALTH INSPECTION SERVICE OM6 NO. 0579-0036



Finch University Of Health Sciences The Chicago Medical School 3333 Green Bay Road North Chicago, IL 60064

I Telephone: (847) -578-3251

I I

I. REPORTING FACILITY ( List all locations Mere animals were housed or used in actual research, testing, or eqxrirnentation. or held for these purposes. Attach additional sheets if necessary ) p- --

FACIUTY LOCATIONS ( Stet ) - See ~tach& Listing

- --

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets i f necessaw or use APHIS Form 7023A 1 -

I


Welfare RegulaUons , -

-

8. Number of animals being -- bred, conditioned. or held for use in teaching. testlng. experiments, research. or surgery but not ye

I

4. Dogs

5. Cats I 6. Guinea Pigs I 7. Hamsters * I 8. Rabbits I

C. Number of animals upon which teaching. research. experiments. or tests were conducted involving no pain. distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted

Mini-Pigs 8 1 96 13. Other Animals

involving aaonpanying pain or distress to the animals and for which appropriate anesthetic, a

ASSURANCE STATEMEJUTS I 1) Professionally acceptable standards governing the cam, treatment. and use of animals, i n d u d i appropriate use of anestetic, analgasic, and tranquilking drugs, prior to. during. and f0l-

E. Number of animals upon which teaching. experiments. mearch, surgery or tests were conducted involving accorrpanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing dwgs would

actual research, teaching, testing, surgery, a axperirnentation were followed by this research facility.

F.


have adversely affected the procedures. results. or interpretation of the teaching, research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these anitrals and the reasons such drugs we= not used must be attached to

2) Each principal invsrtipbr has considered alternatives to painful procedurer.


3) This facility is adhering to the standards and regulations under the Act, end it has required that arceptions to the standards and regulations be specdied and explained by the prindpal investigator and approved by the lnstiional Animal Care and Use Carmittee (IACUC). A summary of all such exceptions Ir attached to thb annual repon In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the mceptions, as well as the species and number of animals afbued.


CERTIFICATION BY HEADQUARTERS RESEARCH FACILilY OFFICIAL ( Chief Executive Oflicer or Legally Responsible lnstiftrtional Official )

DATE SIGNED -- -

SIGNATURE OF C.E.O. OR INSTI

10/18/0;) APHIS FORM 7023 ( ~ e ~ l

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. 33-R-0033 ANIMAL AND PLANT HEALTH INSPECTION SERVICE FORM APPROVED

, Customer No. 589 OM6 NO 0579-0036

2. HEADOUARTERS RESEARCH FACILITY (Ndrnc? d#td Atldrrss. as regrsfur~d wrth 8 I

rr~cltrrk 3 1 ) C o t l ~ l

ANNUAL REPORT OF RESEARCH FACILITY Aventis Behring LLC (TYPE OR PRINT) Route 50 North

Bradley, IL 60915 N0~282u02

Telephone: (815) 932-6771 3. REPORTING FACILITY [ t ~ s l all l o r d l ~ o ~ ~ s where J~IIIIIJIS were hotr~t*d or ubed 111 J( IIIJI resewc.h. lesllttg. Ie~(.hlttg. or expertrnenlaIIot~. IN h ~ l d 101 lht:se I)UIC)OS~S A I I j ch ~d(11l1ortal

sheets 11 necessary )

L I FACILITY LOCATIONS (Srles)

--

~REPORT OF ANIMALS USED BV OR UNDER CONTROL OF RESEARCH FACILITY (Altach ~t lr t t r t rort~l sllcetr rt rwcc8ssdrv or use APHIS FORM iO?M,

Animals Covered By The Antmal

Welfare R e g b l ~ l i ~ n S

B Number o l antrnals be1119 bred. cotrdrltoned, or held lor use In leachtng. lesltttg. exprlmellls. research. or suryery bul 1101 yet used lor such purposes.

4. Dogs I 5. Cats

6. Gumea Pigs

7. H a m s t e r s 1

8. Rabbits

10. Sheep I 11. Pias

I 12. O the r Farm Animals

13. Other Animals t I ASSURANCE STATEMENTS

C Nurnber o l JIIIIIIJI~ upon wh~ch Ieachtrq. rasearch. experttnenls, or tests were conducted ltrvolvlog 110

pdtn, dlslress, or use o l pmt- reltevtng drugs

D Nutnlw o l vt~t~nals ul~o11 whlch experlrnetrls, teachttrg. research. suryery. or lesls were

1 cot~ducled ~tivolvt~tg accompalrylny palm or d~stress l o the at~rtnals and lor whtch approprlale aneslhellc. analgesic, or I rat~qui l l r~ng druys were used

E. Number d dtittnids upon whlch le~chlt lg. expertrnenrs. research. surgery or lesls were cocdt~cled itwolvtng accoinparry~rig pain or dtslress to Ihe atr~mals aod lor wh~ch I t ~ e use o l approprtate anesthet~c. alr~lyestc. or Irar~qu~lrztng drugs would have adversely allected the procedures, resulls, or mlerprelallon o l the leachrng. research. experttnenls. surgery. or tests (An erplanalion 01 Ihe procedtrres productr~y part1 or drstress rrt these animals and the reasons such drugs were rtol used nwst be attached l o thrs report)


(Colt. C + 0 + E)

1) Prolesstonally acceptable standards governtrly Ihe care. Ireattnent. and use 01 awrnals. rrrcluding apprortate use o l aneslhetic, analgesic, and tranqulluiay drugs, prior lo, during. and following actual research, teach~ng. lesttng. suryery, or expertme~rtation were lollowed by thts rewvrch Iacllily

2). Each prtnctpal invesliyalor has cons~dered alteroal~ves l o patt~lul procedures

3) Thts lac~l l ty is adhering lo the standards and regu l~ l~ot ts under the Acl. and tt has rcqulred lhal excepllons lo the slat~dards arrd regul~ltons be spec~lted and explatned by the prlnclpal investigalor and approved by Ihe 1nsltl11ltott;rl A~I I~ IJ~ Care and Use Cotntnillee (IACUC) A summary ol al l such exceptions i s at tached t o this annual report In addillon l o iden l~ ly~ng the IACUC.approved excepllons, thts summary ~lrcludes a briel explirn~ltoo of the excepttons. as well as Ihe spectes and trumber o l ~ n t r n ~ l s attrcted

4). The attettd~ng veterttlarlatl lor lhts research lac~l t ly hiis approprldle dulhortly l o ensure Ihc provlslutr o l adequate velertndry care and l o oversee the adequacy o l other aspects of anlrnal care and use

CEHTII21CATIOFi HY 11 EADQUARTES HESEAHCH FACILITY OFFICIAL cutive Officer or Legally Responsible Instilulional Official)

fy lhal Itbe above IS I r w . correct. and cotnplele (7 U S C Sec;lton 2143) I

NAME 6 TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Prrtjl)

(OCT 88). r*t~tc.h IS obsolete j

(AUG 91) 94.97 ? . c4aDQUAFlTERS

~ i c o n k e / ~ e ~ i s t r a n t Name: Avnnt i s B n h r ino

License/Registration Nunbe=: 3 3 R- 0 0 3 3

Please l i s t below a l l s i t e s that house regulated animals under t h e above number. BS sure to include all requested information. If t h e line does not apply, please mark it N/A. If you have more than three ( 3 ) s i t e s ccpy this form as many times as needed before f i l l i n c r i n t h e s ites-

S i t e No.:

Address : R n ~ i t ~ 50 N n r t h

B rad l ey , IL 6 0 9 1 5

Building: N- 17

S i t e No.: Name/Department:

Address :

Building :

Floor/Room:

Contact Person: Phone No. :

- --

S i t e No.: Name/Department :

Address :


Th~s report IS required by law (7 USC 2143). Fa~lure to report according to the regulations I mn

Interagency Report~ontrol No.:

-



UNIJED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I FORM APPROMD

OMB NO. 05790036

I

- 1

D

Hektoen Institute For Medical Research , t. L . C . 627 S. Wood Street Chicago, IL 60612

3. REPORTING FAClLlM ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Attach additional sheets if necessary )


Telephone: (31 2) -738-31 00

FAClLlM LOCATIONS ( Sites ) - See Atached Listing

C. Numberof animals upon which teaching, researoh. experiments, or tests were conducted involving no pain, distress, or use of patn- relieving drugs.

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I D. Number of animals

upon which experiments, teaching. research, surgery. ot. tests were conducted involving

E. Number of animals upon which teaching, experiments. research, surgery of tests were conducted involving amrnpanying pain or distress Lo t?e anirrsis &A :or which d e rise cf ap~rcl;Aa:a anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures, results. or interpretation of the teaching, research. experiments, surgery. or tests. ( A n explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

I k

Animais Covered By The Animal

Welfare RegukUons

I TOTAL NUMBER OF ANIMALS

B. Number of animals being '- bred. conditioned. or held for use in teaching. testing, experiments. research, or surgery but not yc


accompanying pain or distress to the animals and for which appropnate anesthetic, a

4. Dogs 1 0

5. Cats

6. Guinea Pigs I I


13. Other Animals I I


1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and ba&iliing drugs,$or to, during, and following actual research, teaching. testing, surgery, or experimentation were followed by this reseerch facility.

2) Each principal investigator has amsidered alternatives to painful procedures.

3) This faality is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be smed and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions 1s attached to thls annual report. In addition to identifying the IACUCapproved exceptions, this summary indudes a brief explanation of the exceptions, as well as the spedes and number d animals affected.

4) The attending veterinarian for this research facility has appropriate authority to enswe the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICLAL ( Chief Exwwtive Officer or Legally Responsible Institutional Official )

DATE SIGNED

APHIS FORM

UNITED STATES DEPARTMENT OF AGRICULTURE 1. CERT#ICATE NUMBER 33-R-0040 ANIMAL AND PLANT HEALTH 1NSPECTK)N SERVICE

CWTOMt3 NUMBER: 580

Northwestern University ANNUAL REPORT OF RESEARCH FACILITY Searle Bldg., Room 15-582

(TYPE OR PRINT ) 320 E. Superior Street Chicago, IL 6061 1

From 10/1/2001-2/6/2002 I Telephone: (31 2) -908-8257

FACllrrV LOCATKINS ( Sites ) - See Aachcd Listing

4. Dogs

5. Cats

6. Guinea Pigs

JSED BY OR UNOER CONTROL OF RESEARCH FACfLTTY I AttacJ~ addhna1 sheet, if mcess;uv w use APHIS F m 7023A 1 1

7. Hamsters

8. Rabbits

9. Nonhuman Primate

10. Sheep

11. Pigs

12 Other Farm Anbnals

13. Other Animals

Chinchillas

Gerbils - -- - -- -

Ground Squirrel I I

C. Number of anirrals upon which tf?a&ing. research. epsiments. or testt wtre conducted invoiving no pan. dislreu, or uscdpain- relieving chugs.

Nw&rd* uponwhich exphmts,teaddnp, resemh. swggr. a tests w e conducted imrdving =-w=vm pain 08- ~ l 0 U l e ~ and kr which appropiate amsthetic. a

E. N u m b e r d ~ u p o n ~ ~ n g . urpaimntsmeychnr~ayattsb~ conducted 'lmno)ving aawrVanying pain w distress to the animals and for whid the use of a-te anestheti~ analgesic, a banquilii drugs would have a & m d y affected the procedures. nurlk. w in(erpeWon d the leaching. wsearch. experiments. surgtwy, a tests. ( An egknation of procedwes producing pain a distress in these animals and the reasons such drugs were not used rmsl be attached to

TOTAL N U W R OF ANIMALS


CERTIFICATlON BY HEJWQUARTERS RESEARCH F A C I W OFFlCW ( C h i i Executive Ofiicer or Cegally R e q m s i i l e ktitotional Omdal)

DATE SIGNED

11/21/02

NOV 2 2 2002 Vice President for Research Northwestern University Rebecca Crown Center

633 Clark Street

Evanston, Illinois 60208-1 108 NORTH WESTERN UNIVERSITY

November 2 1,2002

Elizabeth Goldentyer, DVM Regional Director- Animal Care 920 Main Campus Drive, Suite 200, Unit 3040 Raleigh, NC 27606-52 13

Dear Dr. Goldentyer:

As you may recall, the Northwestern University research facility registration that was due for renewal on - February 6,2002 lapsed, and was not renewed until April 1 1,2002. The break in registration was

identified and cited in the USDA inspection report of June 1 1,2002, by Dr. Kenneth Kirstein, DW1, USDA, APHIS, Animal Care. In accordance with the advice provided by your office, we enclose two Annual Reports of Research Facility (APHIS form 7023). The regulated activities from October 1, 200 1 to February 6,2002 were performed under registration number 33-R-0040 and the regulated activities from April 1 1, 2002 to September 30, 2002 were performed under registration number 3 3 -R-0 1 29.

We were also advised to provide information on the numbers of animals covered by the Animal Welfare Regulations and used during the break in registration, as follows:

We trust that this will provide the information required to accurately report our animal use during the last year. If we can be of any further assistance or provide additional clarification please contact me.

Sincerely,

.

Pain Level D D D D D

I D D D D D D

Species Dogs Cats Guinea Pigs Hamsters Rabbits Non-Human Primates Pigs Goats Chinchillas Gerbils Ground Squirrels

Numbers 12 30 6 163 115 5 1 27 5 10 157 23 ,


Interagency Report Control No.: Th~s report is required by law (7 USC 2143). Fa~lure to report according to the regulations



can

( FORM APPROVED k

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I OMS NO. 05794036 %w

r*. f - L/

University Of Illinois At Springfield Off. Of Provost & Vcaa, Pac530 P.O. Box 19243 Springfield, IL 62794

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary )


Telephone: (21 7) -5L66r66 1 4

FAClUM LOCATIONS ( Sites ) - See Atached Listing

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 I k 6. Number of (

animals being 1 bred,

Animals Covered conditioned. x By The Animal held for use in

Welfare Regutatlono teaching.

testing. experiments. research, or surgery but not yc

C. Number of animals upon which teaching. research. experiments. or tests were conducted involving no pain. distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments. teaching. research. surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching. experiments, research. surgery or tests were conducted invdnng accompanying pain or distress to the anim!s md for which the use of ap?ropnate anesthetic. analgesic. or tranquilizing drugs would

TOTAL NUMBER OF ANI:*GLS

have adversely affected the procedures. results. or interpretation of the teaching, research. experiments. ( COLUMNS

C + D + E ) surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

4. Dogs I 5. Cats

6. Guinea Pigs

7. Hamsters 12

8. Rabbits

9. Non-human Primate -

10. Sheep I 11. Pigs I 12. Other Farm Animals I I

13. Other Animals I I


1) Professionally acceptable standards governing the care, treatment, and use of animals, induding appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during. and following actual research, teaching, testing, surgery, or experimentation were followed by this research facility.


3) This fadllty is adhenng to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speafied and explained by the princjpal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report In addition to identiing the IACUC-approved emeptions, this summary includes a brief explanation of the except'ms, as well as the species and number of animals atlected.

4) The atending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary cars and to oversee the adequacy of other aspects d animal care and

CERnFlCATlON BY HEADQUARTERS RESEARCH FACILTTY OFFlClAL

( AUG 91 )

DATE SIGNED

1111 1/0: D

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE I 1. CERTIFICATE NUMBER: 33-R-0062

CUSTOMER NUMBER: 574 I FORM APPROVE3 0MB NO. 0579-CC2'


Western Illinois University One University Circle Macomb, IL 61455

. REPORTING FACILITY ( List all locations where animals were housed or used ~n actual research, testing, or experimentation, or heid for these purposes. Attach additional sheets lf necessary ) 3 I

ggoner H a l l , One U n i v e r s i t y C i r c l e Wes te rn I l l i n o i s U n i v e r s i t y , Macomb I L 61455 ~ACILTPI LOCATIONS ( Sites ) - See Atached Listino . .

Rooms 7 , 9 t h r o u g h 3 6 , 4 1 , 4 2 , 43 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A 1

A.


Welfare Regulations

4. Dogs -

I I I --- -

5. Cats I -0 - -0-

6. Guinea Pigs

7. Hamsters

8. Rabbits

9. Elon-human Primate

10. Sheep

1 1. Pigs

B. Number of animals being bred. conditioned. or held for use ~n teaching. testing, experiments.

research, or surgery but not ye

-0-

12. Other F a n Animals

1) Professionally acceptable standards governing the care. treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, ~ d f & o w i n g actual research, teaching. testing, surgery, or experimentation were followed by this research facility.

-0 -

-0-

-0 -

-0-

-0-

-0-

13. Other Animals

o l d f i e l d m i c e [ ~ e r o m y s c u s

yu-a J 1

I 2) Each principal investigator has considered alternatives to painful procedures

C. Numberof animals upon which teachmg. research. experiments. or tests were conducted involving no pain. distress, or use of pain- relieving drugs.

-0-

-0-

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speufied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions. this summary includes a brief explanation of the exceptions, as well as the species and number d animals affected.

5

-0-

-0-

-0-

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care ard

t CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL

D. Number of animals upon which experiments. teaching. research. surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic. a

SI rint IDATE SIGNED

- --

107

E. Number of animls upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropnate anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures, results, or interpretation of the teaching, research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

- - -- - - - -

-0-

-0-

5

-0-

-0-

-0-

F.

TOTAL NUMBER OF ANIhULS


-0-

- --

. 107

1 2 / 4 / 0 2 ;

AP

Thts report 1s requmd by law (7 USC 2143) Fa~lure to report according to the regulations can result in an order to cease and desist and to be subject to penalt~es as provlded far In Sect~on 2150

See reverse side for additional informat~on

Interagency Report Control No 01 80-DOA-AN


I DE KALB. IL 601 15 I


I

) 3. REPORTING FACILITY (Llst all locations where animals were housed or wed in actual research. testing. teaching. or experimentation, or held for these purposes. Attach additional 1

1. REGISTRATION NO. CUSTOMER NO. 33-R-0067 575

I 2 HEADQUARTERS RESEARCH FACtLiW (Name and Address, as registered with USDA,

indude z p code) NORTHERN ILLINOIS UNIVERSITY

J sheets if necessary.) J FACILITY LOCATK)NS(sites)

DEPT. OF BIOLOGICAL SCIENCES DE KALB, IL 601 15


C. Number of animals upon which teaching. research, experiments. or tests were conducted involving no pain. distress, or use of pairr relieving drugs.

F.


(Cds. C + D + E)

D. Number of animals upon which e-ents. teaching. research. surgery, or tests were conducted involving accompanying pain or distress to Vw, animals and for orwhich appropriate anesthetic, analgesic, or tranquilizing drugs were used.


I 9

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClUM (Attach additional sheets #necessary or use APHIS FORM 7023A )

E Number of animals upon wtu& teaching. experiments. research. surgery or tests were oonduded involving accompanying pain w distress to the animals and for which the use of appropriate anesthetii.analgesic, or tranquilizing drugs would have adversely affected the procedures, ~e~ults. or interpretation of the teaching, research. experiments, swgery, or testt. (An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to this report)

3) This facility is adhering to the standards and regulations under the Aq and it has required that exceptions to the standards and regulations be speafied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all tho exceptions is attached to this annual repott In addition to ident~fying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the spedes and number of animals affected.

A

Antmals Covered By The Animal

Welfare Regulations

4. Dogs

5. Cats

4) The attending veterinarian for this research facility has appropriate wthority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional official)

I certify that the above is true, correct, and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL I NAME i% TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Print) I DATE SIGNED

6. Guinea Pigs

-

- 9. Non-Human Primates


1) Professionally acceptable standards governing the care, treatment, and use of animals. including appropriate use of anesthetic, analgesic, and tranquilizing drugs. prior to. during. and following actual research, teaching, testing, surgery, or experimentation were followed by this ressarch facility.

6. Number of animals being bred. conditioned. or held for use in teac+ing, testing. experiments. research, or surgery but not yet used for such purposes.

1110612002 I

I

- - -

I I I I

APHIS FORM 7023 (Replaces VS FORM 18-23 ( ~ c t 88). which is obsolete PART 1 - HEADQUARTERS (AUG 91)

"C 0' 200' ,eeat,ched,rnfor Thts report IS required by law (7 USC 2143). Failure to report according to the regulations - a n addrt~onal information


- - - - - --



Telephone: (31 2) -583-4050



I. REPORTING FACILITY ( List all locations where animals were housed or used in actual research, testing, or experimentation, or held for these purposes. Amch additional sheets if necessary )

FORM APPROVED OM0 NO. 05790036

FACILITY LOCATIONS ( S i i ) - See Atached Listing

Northeastern Illinois University Office Of The Provost 5500 N. St. Louis Avenue Chicago, IL 60625

I REPO~T OF ANIMAL* USED BY b~ UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets i f necessarv or use APHIS Form 7023A 1 I


Welfare Regulations

B. Number of animals being -- bred. conditioned. or held for use in teaching. testing. experiments. research, or surgery but not ye

6. Guinea Pigs - 7. Hamsters

8. Rab:its


10. Sheep

1 1. Pigs


13. Other Animals

C. Number of animals upon which teaching. research. experiments, or tests were conducted involvlng no pain. distress. or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaming. research. surgery, or tests were conducted involving acwrnpanying pain or distress to the animals and for which appropriate anesthetic. a

E. Number of animals upon which teaching, experiments. research, surgery or tests were conducteG+wi~ing accornpanyng pain or oisuess to the animals and for which the use of appropriate anesthetic. analgesic. or tranquilizing drugs would have adversely affect& the procedures, results. or interpretation of the teachtng, research. experiments, surgery, or tests. ( An explanation of the procedures produang pain or distress in these animals and the reasons such drugs were not used must be anached to



I

ASSURANCE STATEMENTS I

1) Professionally acceptabte standards governing the cam, treatment, end use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following actual research, teaching, testing, swgery, or ex$xrhentation wem followed by this research fadtii.


3) This facility is adhering to the standards and regulations under the Ad, and it has required ?hat exceptions to the standards and regulations be speatied and explained by the principal investigator and approved by the InstiMionaI Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, 8s well as the species and number d animals deded.


CERTIFICATION BY HEADQUARTERS RESEARCH FAClLrrY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

( AUG 91 )


UNITEO STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE

I Wheaton College 501 E. College Ave.

"0 2.9 2w Wheaton, IL 60187

1. REGISTRATION NO. 1 FORM APPROVED

33-R-0088 OM6 NO 0579-0036

2. HEADOUARTERS RESEARCH FACILITY (Name and Address. as reyistered wtth USDA J

tnclude ZIP Code)

3. REPORTING FACIL lN (Ltst all locartons wtlere an~mals were housed or used tn Jctual research, lesttttg. leachmy. or expectmentatloo. or held lor these purposes. Allach Jddtllot~al sheels 11 twceswry )

FACILITY LOCATIONS (Srles)

I Biology Department, Armerding Hall

0. Number ol at~tcnals upon wh~ch erperclnenls. teachrng. research. surgery, or tests were corw3ucred ~rtvolvtng accompanyrng patn or dtstress lo the ~rllm;lls and lor wh~ch appropr i~le aoeslhel~c. at~algestc. or Iro~~qucltzing drugs were trsed

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILIT cessurv or trse APHIS FORM 7023A)

E. Number ot antmals upon whach Ieach~ng. 1 expermenls. research, surgery or tests were coriducled ~rivolvtng accompdnymg pa181 or d~stresa l o Ihe J ~ ~ I S and lor wh~ch Ihe use ot Jpproprcale aneslhettc. analgesrc. or Iranqu~lrang drugs would have adversely ~ f k c l e d the procedures, resulls. or tnterprelat8on o l Ihe leaching. research. experwnenls, surgery. or lesls (An erplanatron 01 Ihe procedures producrny pain or d~stress m these animals and Ihe reasons such drugs ware no1 used nwsl be atiached to this report)

C Number 01 antrnals upon whlch leachtcq. research. erpttr~menls. or tests were conduc led ~ n v o l v ~ r ~ y no pin. distress. or use 01 p ~ ~ ~ ~ - relrevtng drugs

A

At:~cnals Covered By The Animal

Wellare Regulal~ons TOTAl NO

OF ANIMALS

B Number 01 ant~nals bemg bred. - condrt~oned, or held lor use ~n teaching. lestlrlg. erper~ments. research. or surgery but rlol yet used lor such purposes

(Cols. C + D + E)

4. Dogs I 1 I I I 5 . Cats I I I I I 6. Gumea Pigs I I I I 7. Hamsters

8. Rabbits

10. Sheep I I I I 1

I I I I I ASSURANCE STATEMENTS

12. Other Farm An tma l s

13. Olher Anlmals

Golden Mantle

Ground Squirrel

I ) P l o l e ~ ~ t ~ l l ~ ~ ~ y acreplable slandards yoverntrty the core. I re~lrnec~l. WIJ use 01 JilltrlitlS. ~ciclud~crg approrrale use 01 anesrhel~c. analgesrc. and I r anc~u t l ~ r~ t~y drcrgs. pr~or lo. durcr~g. and lol lowc~y actual research. trachmg. lestcng. surgery. or exvcrcrnet~tatsoo were lollowed by rh~s research l ac~ l~ r y

2). Each prtnc~pel tnvesltyalor has corlsldered J l l ~ l l l ~ l l ~ e ~ l o pi11111ui procedures

I I I I I

1 1

K T I ' ' 2002 See attached form for add~tional infomtion

This report is required by law (7 USC 2143). Fa~lure lo report according to the regulations can


1. CERTIFICATE NUMBER: 33-R-0094 FORM APPROVED OMB NO. 0579-0036


I Pharmichem Testing Services, Inc. 17501 W. Duvan Drive Tinley Park, IL 60477


I Telephone: (708) -429-4040

- - - - - - - - - . REPORTING FACIUTY ( L~st all locations where anlmals were housed or used in actual research, test~ng, or experimentation, or held for these purposes. Attach addttional sheets d necessary ) I

FAClLrrY LOCATIONS ( S i i ) - See Atached Listing

( REPORT OF ANIMALS - - - - - - - -- - --

JSED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessaw or use APHIS Form 7023A I 1 5. Nc&or;f

animals being -.. bred, conditioned, or held for use in teaching. testing. expenrnents, research. or surgery but not ye

C. Nuesr cf animals upon which teaching. research. experiments. w tests were conducted involving no pain, distress, or use of pain- relievina dtuas.

D. Nm!xr cf aainuls upon which experiments. teaching. research. surgery, or tests were conduded involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Ncxber C! ar;i=!t uW v f i * ttea~\iq. experimen:s. research. surgery or tests were conduded involving accompanying pain or distress to the animals and for which the use of appropriate anesthetic, analgesic. or tranquilizrng dtugs would have adversely affected the procedures. results. or interpretation of the teaching. research. experiments. surgery, or tests. ( An explanation of the procedures produang pain or distress in these animals and the reasons such drugs were not used must be attached to



Wetfare R ~ u h t l o n s ( COLUMNS C + D + E )

5. Can 0

1 1. Pigs

12. Other Farm Animals m 13. Other Animals I+ I ASURANCE STATEMENTS I

1) Professionally acceptable standsrds governing the care, lmatment and use of animalt, inchding appropriate use of anestetic, analgesic, and tranquilizing dmgs. prior to, during, and following adual msewch, teaching, testing, surgeuy, or -mentation were followed by this research facility.

2) Each principal investigator has considered alematives to painful procedwes.

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speafied and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report In addition to identifying the IACUC-approved exceptions, this summary indudes a brief eqlanetion of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has appropriate autwity to ensure the provision of adequate veterinary cars and to wsnee the adequacy of other aspects of animal cam and

CERTlFlCATlON BY HEADQUARTERS RESEARCH FACILITY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Official )

( AUG 91 )

DATE SIGNED

10/1/02

This report is required by law (7 USC 2143). Fa~lure to report according to the regulations *?.- additional informtion Interagency Report Contrd o. 4


1. CERTlFlCATE NUMBER: 33-R-0100

CUSTOMER NUMBER: 571 I FORM APPROVED OMB NO. 0579-0036 I

I Parkland College 2400 W. Bradley Avenue Champaign, IL 61821


I Telephone: (21 7) -351 -2200

I I I. REPORTlNG FACILITY ( List all locations where animals were housed or used in actual fEaWch. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary )

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A I B. Numberof -

animals being _ bred. conditioned. or held for use in teaching. lesting. experiments. research, or surgery but not ye

C. Numberof animals upon v.ki,J: :scC.ing. research. experiments. or tests were conducted involving no pain. distress. or use of pain- relievmg drugs.

0

0. Number of animals upon which aqeiimt, 13, tsa;'.iq. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

Number of animals upon which teaching. experiments, research. surgery or tests were ccnducietf invoiving accwryanyirlg pan or distlrss to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching. research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to


Animals Covered By T b Animal

Welfare Reguptiom ( COLUMNS C + D + E )

4. Dogs 0 5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits

10. Sheep 0 I 0 I 0 I 0 1 0

0 0

0

0 9. Non-human Primate

12. Other Farm Animals : 13. Other Animals

I I I I 0 0

ASSURANCE STATEMENTS I 1) Professionally acceptable standards governing the care, treatment, and w e of animals, including appropriate use of anestetic, analgesic, and tranquiliting drugs, prior to, during, and following

ectual resea&, teaching, testing, surgery, or experimentation were followed by this mead! facility.

0


mice rats

3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be @ed and eqlained by the prindpal investigator and approved by the lnstiional Animal Care and Use Committee (WCUC). A summary of all such exceptlons Is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the W e s and number of animals affected.

0

36 0

4) The attending veterinarian for this research facility has appropriate authority to ensum the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal care and _L

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Ofiicer or Legally Responsible Institutional Official )

0

0 0 8

DATE SIGNED

0 0

A obsolete.

(AUG 91 )

0 8

DEC 1 2 2002 Seeattachedfmfor Th~s report 1s requlred by law (7 USC 2143). Fa~lure to report according to the regulations - can addrtional information

Interagency Report Contrd "I$-' UNITED STATES DEPARTMENT OF AGRICULTURE

ANIMAL AND PLANT HEALTH INSPECTION SERVICE




I Kennelwood, lnc. 1913 N. Staley Road Champaign, IL 61821


I

). REPORTING FACIUTY ( List all locations where animals were housed or used in actual research, testing, w expenmentation, or held for these purposes. Attach additional sheets if necessary ) 3

1

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A \ I


Welfare Regulatlons

6. Nurnberof - animals betng - bred, conditioned. or held for use in teaching. testing. experiments, research, or surgery but not ye

5. Cats

6. Gcinea Pigs

7. Hamsten

C. Numberof

whlch teaching. I research. expenrnents, or tests were conducted involnng no pam, distress, or use of Pam- relievmg drugs.

D. Number of animals upon Mich experiments, teaching. research, surgery. or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropnate anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures, results. or interpretation of the teaching. research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



-

8. Rabbits 1 / I 9. Non-human Primate

10. Sheep

1 1. Pigs t 12. Other Farm Animals I I

13. Other Animals

\

1 ASSURANCE STATEMENTS I 1) Professionally acceptable standards governing the care. treatment, and use of animals, including appmpriste we of anestetic, analgesic, and trenquiliring drugs, prior to, during, and following

actual research, teaching, testing, surgery, or axperirnentati?n were followed by this rsrsarch tad i i .

2) Each principal investigator has considered alternatives to painful pmadums.

3) This facility is adhering to the standards and regulations under the A4 and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions is attached to this annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions. as well as the species and number of animals affeded.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal Cam and 1

CERTIFICATION BY HEADQUARTERS RESEARCH FAClLllY OFFICIAL ( Chief Executive Officer or Legally Responsible lnstihrtional Official )

I DATE SIGNED

APHIS

TIIS report 1s requlred by law (7 USC 2143) Fallure to report accorc?~r,g 'o :he regb atlois can result tn an order to cease and deslst and to be subject to penalties as prov~ded for In Sed~on 21 SO

See reverse slde for addit~onal mforrnatlon

Interagency Report Control No 01 80-DOA-AN

2. HEADQUARTERS RESEARCH FACILITY (Name and Address as regrstered wtth USDA, ANNUAL REPORT OF RESEARCH FACILITY rnc~u~ie ~ l p Code)

(TYPE OR PRINT) UNIVERSITY OF ILLINOIS AT CHICAGO 1601 PARKVIEW AVENUE

UNITED STATES DEPARTMENT OF AGRICULTURE 1. REGISTRATION NO. CUSTOMER NO. ANIMAL AND PLANT HEALTH INSPECTION SERVICE 33-R-0104 566

I ROCKFORD. IL 61 107-1 897 I

FORM APPROVED OMB NO. 05794026

I

3. REPORTING FACILITY (Lrst all locations where ammals were housed or used in actual research. test~ng, teach~ng, or experimentatton. or held for these purposes. Attach addltronal sheets lf necessaw I

FACILITY LOCARONS(srles)

U OF IL -COLLEGE OF MEDICINE @ ROCKFORD ROCKFORD. IL 61 107

6, Number of animals betng bred, conditioned. or held for use In teaching, testing, expenments. research. or surgery but not yet used for such purposes.

animals upon which teaching, research, experrments. w tests were conducted mvolving no pain. distress, or use of pain- relievmg drugs.

D. Number of animals upon which experiments, teachmng. research. surgery, or tests were conducted ~nvolv~ng accompanying pain or distress to the animals and for which appropriate anesthetic. analgesic, or tranquiliztng drugs were used.

E. Number of animals upon wh~ch teachrng. experiments. research, surgery or tests were conducted involving accompanying pain or distress to the an~mals and for which the use of appropriate anesthetic.analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching, research. expenments. surgery, or tests. (An explanation of the procedures producing pain or distress m these animals and the reasons such drugs were not used must be attached to this report)

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY (Attach addrbbnal sheets rf necessary or use APHIS FORM 7023A ) I

A.

Anmals Covered By The Anlmal

Welfare Regulations

4. Dogs

5 Cats

6. Guinea Pigs

7 Hamsters

8. Rabbits

9. Non-Human Primates

10. Sheep

11. Pigs


13. Other Animals

gerb~ls


1) Professionally acceptable standards governing the care, treatment and use of animals, including appropriate use of anesthetic. analgesic, and tranquilizing drugs, prior to. during. and following actual research, teaching, testing. surgery, or expenmentation were followed by this research facility


(Cols. C + D + E)


3) Thrs facility is adhering to the standards and regulations under the Act. and it has required that exceptions to the standards and regulations be specified and expla~ned by the principal investigator and approved by the Inst~tut~onal Anrrnal Care and Use Committee (IACUC). A summary of all the exceptions is attached to this annual report. In addit~on to identifymg the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected

4) The attending veterinarian for this research facllity has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of an~mal care and use.

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL (Chief Executive Officer or Legally Responsible Institutional official)

I certify that the above is true. correct: and complete (7 U.S.C. Section 2143) SIGNATURE OF C.E.O. OR INSTITUTIONAL OFFICIAL NAME & TITLE OF C.E.O. OR INSTITUTIONAL OFFICIAL (Type or Pnnt) DATE SIGNED

1 1210512002 I APHIS FORM 7023 (Replaces VS FORM 18-23 (Oct 88), which is obsolete

(AUG 91) PART I - HEADQUARTERS

12/11 '02 1546 1D:U of I PEORIA FAX ~309-671-8513 PAGE 2 Y UNITED STATES DEPARTMENT OF ACRlCULWRE

ANlMM AND PUNT HEAL7 H INSPPCTION SERVICE

ANNUAL REPORT OF RESEARCH FAClLiTY ( TYPE OR PRINT )

UnlversHy Of llllnole College Of Medicine At Peoria P. 0. Box 1649 Peoria. IL 61 0.56

I Talephone: (300) -67 1-8525 I

( COWMNS C * D + E )

Th~s report is required by law (7 USC 2143). Fa~lure to repofl according to the regulations ,--,. See attachtd form far additional information

Interagency Report ConM No.:

UNITED STATES DEPARTMENT OF AGRICULTURE ANWAL AND PIANT HEALTH INSPECTION SERVICE

ANNUAL REPORT OF RESEARCH FACILITY ( TYPE OR PRIM )

Southern Illinois University School Of Mediane P. 0.80~ 19620 Springfield, iL 62794

I Telephone: (21 7) 445-3625

FACILITY LOCATIONS ( Sites ) - See Atached Listing

- -

REPORT OF ANlMALS USED BY OR UNDER CONTROL OF RESEARCH FAClUM I Atbch additional

13. Other Animals

3) This facility b adhering to the standards and regulation8 under the Act, and it has required that exceptions to the standards and regulatiwu be specified and explained by ths principal investigafor and appmed by the InscituUonal Animal Cam and Use Committee (IACUC). A summary of all such r x c e p t l o ~ Is attached to thls annual repoh In addition to identiing the IAClJC-appmved sxceptioru, this summery induder a kief explanelion d the exceptions, aa well as the specie8 and number of rnimak affected.

she&~ if rrsaerun, or use APHIS Form 7023A I

,

Chinchilla

4) The attendim veterinarian fix this famsrch facility ha8 appropriate arVlority to ensum tha provision d adequate veterinefy cam end to oveneo the adequacy of other aspsds of animal crve and

CERTIFlCAllON BY HEADQUAKERS RESEARCH FACUrrY OFFICIAL ( C h i e f ~ O m c e r # L ~ R e s p o r r s i b l e t n s t i t u t k n a l O m c i a l )

I

I

85 85 1.

E. ~ d ~ u p o n m m c h i n g , ~ t S r e s c a r r h . t u r ~ e r y O r t e r t S w t r r aanduded imdving accarpanying pain a d b & s D o t h c ~ r d f o r ~ t h e u s e d a p f m @ a k ancsthctlC anaIgesic, ar banquitidng drugs wovld ha~sdvendyafkdadthepr#+d~rrudts.~ h- or he ormp - olperi- s u ~ ~ . ~ t e s b . (AnewJmatkndmaprocEdues prodrdngpainadbbessintheseaninabandIhc reasons such drugs were not used mst be attadnd to

D. Nwbxdanhnets upon Aidl -teactrkrg.

svgery.or t c s t r m r s m e d imching ##npsnying pain or dislrcss to m~ animals and for whi& appropriate anesthetic a

40

12

ATE SIGNED

10/16/02

F.



48

12

c. Nwnberai -won vvhichteachlng,

. ressarch. W m m l f U teas m c a l d u c ~ imrdvingno pain.dtstress.a use d pain- rdieving drugs.

8

k

Anhubcovefed Lty The ~ n f m a l

W a h n Regul.tlons

4. Dogs

5. Cats

6. Guinea Pi-

7. Hamsters

8. rabbit^


10. Sheep

2 L

APHIS F

11. Pigs

12OtherFarmAnimals

B. Number of animals being - bred cmmomd.a hdd for use in teaching. - -tr. re-seardr. a nwgery but not y€

2

, Th~s iepc t IS requ~red by law ( I USC Zl43). Fa~lure lo repor! accordmg to the regulations N 0 V 2 7 2002 Sealtached form for Interagency Report Control No.: u n additional informtion

UNfTED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE


Loyola University Of Chicago Research Services Sky Bldg 307 6525 N Sheridan Rd Chicago, lL 60626

1. CERTIFICATE NUMBER: 33-R-0 1 19 CUSTOMER NUMBER: 562

Telephone: (773) -508-2471

FORM APPROVED OMB NO. OS190036

m J 3. REPORTING FACILITY ( List all locations where animals were housed or wed in actual research, testing. or experimentation, or held f a these purposes. Attach additional sheets if necessary )

FACILJW LOCATIONS ( Sles ) - See Atached Listing

I REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessan, or use APHIS Form 7023A 1 I


Welfare R ~ u b t l o n s

4. Dogs

B. Number of :

animals being bred. conditioned. or held for use in teaching. testing, experiments. research. w surgery but not ye

C. Number of animals upon which teaching. research,

, experiments, or tests were conducted involving no pain. distress. or use of pain- relieving drugs.

I

I D. Number of animls upon which experiments, teaching. research. surgery. or tests were mduded involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. eqeiments, research, surgery or tests were conduded involving accorrpanying pain or distress lo the a n i d s and for w h i the use of appropriate anesthetic. analgesic. or tranquilizing drugs would have adverse affected the procedures, results. or inlerpretation of the teaching, research, experiments, surgery, or tests. ( An expfanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



5. Cats I I I I - - 1

8. Rabbits I I I I

6. Guinea Pigs - 7. Hamsters


10. Sheep

- -

I ASSURANCE STATEMENTS I

1 1. Pigs


1 3. Other Animals

Ground Squirre

Chinchillas

1) Professiooally accaptaMe r&ndards governing the care, batmmt, and use of animals, indd i sppropriate use of anestetic. analgesic, and tranquilizing drugs, prior to, dving. and following actual nuearch, teaching, testing. surgery, or eqmimentation were followed by this research facility.

2) Each principal investigator has conridered alternatives to painful procedures.

3) This facility is adhering to the standards and regulations under the A4 and it has required that excaptions to the stadads and regulations be specified and explained by the principal investigator and approved by the lnstiMional Animal Care and Use COmmitt~ (lACUC). A summary of all such exceptlons ir attached to thls annual report. In addition to identifying the IACUC-approved exceptions, this summary indudes a brief explanation of the exceptions, as well as the species and number of animals affected.


Ls

5

15

12

- -

15

17

APHIS Form 7023 Site List

The following sites have been reported by the facility.

Registration Number: 33-R-0 1 1 9 Customer Number: 562 Facility: LOYOLA UNIVERSITY OF CHICAGO

RESEARCH SERVICES 6525 N SHERIDAN RD CHICAGO, IL 60626 (773) 508-2471

LAKE SHORE CAMPUS DAMEN HALL 6525 N. SHERIDAN ROAD CHICAGO, IL 60626

This repc .s requtreu by law (7 USC 2143). Fa~lure to report according to the regulations See attached form for 0 C? 0 2002 additional inforimation can



L

1. REPORTING FACILITY ( List all locations where anrmals were housed or used in actual research. testing, or experimentation. or held for these purposes. Attach additional sheets if necessary)

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FAClLrrY I Attach additional sheets if necessarv or use APHIS Form 7023A \ 3

1. CERTIFICATE NUMBER: 3 3 - ~ - 0 1 20 CUSTOMER NUMBER: 563


Welfare Regulations


8. Number of :

animals being h r d conditioned, or held for use in teaching. testing. expenments. research. or surgery but not ye

Bioproducts, Inc. 1048 S. Hieland Road St Anne, IL 60964

Telephone: (81 5) -935-0900

4. Dogs

5. Cats

13. Other Animals I

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep

( ASSURANCE STATEMENTS

I \ ~ A

MA C\/A NA

C. Number of animals upon which tt+a&ir?g, research. experiments. or tests were conducted involving no pain. distress. or use of parn- relieving drugs.

11. Pigs FJA 12. Other Farm Animals MA

D. Number of animals upon which exp+mtr, t o ~ c k i n ~ . research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of animals upon which teaching. experiments, research, surgery or tests wet- cr?&urf::! ir.~!.,+ng =cscpz.?;-i:g s i n j i z t - ~ s to the animals and for which the use of appr :,xiate anesthetic. analgesic. or tranquilizing drugs waul\' have adversely affected the procedures, results. or interpretation of the teaching, research, experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to



1) Professionally acc%pbbk standards !Joveming the care, treatment, and use of animals, induding appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following achral rese&, teaching, testing, surgery, or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be specified and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptloru Is attached to this annual report. In addition to identifying the IACUC-approved exceptions. this summary indudes a brief explanation of the exceptions, as well as the species and number d animals affected.

4) The attending veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other aspects of animal cant and

CERnFlCATlON BY HEADQUARTERS RESEARCH FAClLrrY OFFlClAL ( Chief Executive Officer or Legally Responsible Institutional Official )

/

rint DATE SIGNED

?,'ar/o -

MU-14-mz a m n UEDA APHIS QC 919 716 5636 P.K/:O 'Iha r w IS r ~ o i r e d 3qLbw (7 U S 2142) FPI~UIC !O lepM BCODTdlng to ;hb wguhbmr rJh see revem l a b rr lrnuagenzy on b t r 3 No p 0 - ~ 1 t n ~ w O M t 0 ~ r d d e * f c n e L b ~~crbjef~crtopenattlww-hl nrOCdm21SC. a a a ~ w 17fcmaaon 0: aoEOkiW

h

U#ITED mATES WARWENT OF AGRICULTW I. REGISTRA~N NO. UJSTOWER NO. ANWL AND HEALTH HSK=tlON SERVI# 53-WI125 9450 FORM PPH(OVE0

I Lu

I 2. nuOQUARTER-- ---------------- ------------- --------- - nd RMnro. as W f S . 9 n d llvM lS&. ANNUAL REPORT OF RESEARCH FACILITY muds r~ corn

( V P E OR PRINT') ----------- ------------- - ---- ------- -----

4 WP l o 5. Cats 0

I

8. b n e a Piis C> I 0 7. hnulen

8. Rabbits 1

I I 10. Sheep

? 1. Pigs

12 Other Pam Aninals

13. O m r Animab -. - - - -

T J

CERTlFICAflON BY HEADQUARTrRS RESEARCH PAClUTV OFFlClAl (Chlef Ex@cutfve Officer or Legalty R~ponr;lbIo InstitutJocrd offlcfaJ)

I cmtifyttat the above is h a . carsd snd mplete (7 U.S.C. k t k x 2143) 'SIGNATURE OF CEO. OR I N S ~ ~ U ~ ~ W A L OFFICIAL

, HAMS 6 TITLE OF CEO. Of? tNSmLCnONAt OFFlClAL vyp or Pnnt) DATE SIGNED

- PART 1 - HEADWARTERS


Annual Report Checklist

Note: The intent of this checklist is to aid in the completion of the APHIS Form 7025 (Annual Report of Research Facility). It is a htonded ta b~ the only reference. Please check with your Animal Care Inspector or Regional Office if you have further qusstio~s OF concerns. For your informatbn: Annual reports will beccrne wailable through the FOIA.

Only one Annual Report submission is authorized per facility.

Report must be legible and all wplicable blanks must be completed.

The cerification signature, by the legally responsible official, and date black must 3e completed without exceptlan.

Animals used in mre than one protocol are counted in the most painfuridistressful category.

Common names of animals must be used under "Other Animals" and "Other Farm Animals".

Report Aid rodents. Do not report the use of laboratory ~ t s , laboratory mice. birds, or othr animals which are exempt from regufatkn under the AWA.

A summaw of exceptions to the regulations and standards. specified and explained by the principal invsstjgator and approved by the IACUC, m w t be attached.

Column E explanation(s) must be attached and must contain: (See attached optional Column E repding form). facility registration number. number and species cf animal for sach Column E a d y , descriptionlexplanation~purpose d study,

scientific or regulatory justification for withholding of painldistress relief (A justifica9an that mere4 states that pain reiief interfere with test results is not adequate.) and multiple Column E explanations must stab the number and species or animal used for & one.

Studies involving "death as an endpoint" of LDxx sb~dies, must & well documented and j-tified.

You do fi need to include tho following in your annual report:

ProtoCoIs Complete site addresses in Block #3 (Location descriptions strch as "Biology Cepartment" are acceptable). Names of UCUC members or Principal Investigators Program of Veterinary Care

N00- 14-2062 02 : 16 USLG RPHI 5 GC 913 7L6 5636 P.03/10

Internet Instructions for Annual Report of Research Facility APHIS Form 7023 and 7023A

We now a w t electronic submissions uh the Internet Go to h&trJ.Jfurrrw,aotis~.aoWas and setect AnnmlEwport Submission.

Y h will need a user Wpassword before attemptin9 to en:^ the arlrnal use survey data (APHIS Form 7023 and 70234). Tne user ldlpabsword allows you to log in at the Animal Care Web sib and begin enterin$ mima1 use surrey data M APHIS Form 7023 and 7023A. The foliowing daps desertbe the pr- for using the Internst to submit the APHIS Fwm 7023 and 7023A.

The P a d R ~ u e d r n c cptfon alkws yob to apply for a password 10 be used when you am ready to enter data far the APHIS Form 7023 and 7023A. You may a h req~est an existing password to be rnaU8d to you. To apply for a password, simply provide y w R m Facility Regletrallon Number and a usend of 6 to 10 cbaraders of your chocaiqj. ARer -llerifyiying your Raesrch Facility Registration Number d m cur reccrds, the Password Request will contirue by ueatlng a cornpurer generated password that will be asocated with your cser id. The p a ~ d will be mailed to the address of record fw j a r research facility.

Mer receiving the password in the mall created utlng Password Request, return to the Animal Care Web site and Choose SubmH/Rovlew/IComd APHIS Fom 7C23. You will be asked to enter your user id and pasewore! in the &gin Form scnen. :The brief U i r ! Form screen that ycx will see is required to verify yoclr gser Id and passwotd for your Research Fscilify. Upon determining a valld user WpassNcwd pa;?, the APHIS Form 7023 wit! be displayed and made available for entering the animal use s m m y data. If m need to r e p a t Other h i m a h , you w!1 be ~ iven an cpportunl!y wing APHlS Form 7023A.

If you enter a value tor Column E, you wtll be pfovfdec with a screen that albws Column E explsnatio?.

Finally, you hll be presented with me Assurance screen. At this pdnt, af!w agreelng to %e terms cC the Assurance statement, you must provide the rime of the s!grabJre of the CEO or institdMal Mc ia l ard the name ar,.? title of the CEO 3r institutional official.

After submintng the sssurance statement you wil be redirected to the statks screen. The status smr! llsls the bmts you haw submitted and the stabs. The status m be Vnff or Ylnal'. UnUl you save F u r work as 'Final' all infcrmation rwnains in r)raft" form. Oraft status allcws you to pri* exit and return at a lakr time !c rake modificatons prior to submitting as "Firial'.

if APHlS requests a correction. to the APHIS F m 7023/7023A submission. you will mxive a C0rrect.m Notification letter and an m a i l (if an m a i l address was ptovided to APHIS) mtificaticn, me Regional Ofice wili .met the APHiS F m 7023/7023A to D M status, You will access !he Web sib?, lqin, make !he necessary cotreetion and submit as Rna L

If the Cerdfkate Hdder requests a cmection, to the APHIS Fam, 7023nOPA submission. piease wntact the respective Reglcnai Offwe. The APHIS Form 70237023A wf!l be re& lo D a f l status. You will nsed to a c e s the Web site, login. make the nec%ssul/ anecJ9n aqd submit as Rnal.

If flu have addrional qudstisns regarding using the Internet to submit your APHIS = o m 7023 and X23A information, please mtad your respective Reglonal Offloe both of which are listed oelm;

USOA, *HIS Animal Care Eastern Region USDA, APHIS Animal Care Westqrn ReglOn 920 Mdn Campus M v e , Sdle 200 2150 h t f e Avenue, Building B. Mail Stop 3 W l l Raleigh, NC 27606 R. Collins, CO 80526 91 871 6W7 9704967378 POC: Joseph Nelson POC: Melanie Pwarfidd

NOU-14-2082 88: 1'' USW RPHI S F1C

INSTRUCTIONS FOR COMPLETION OF APHIS FORM 7023 (Refer lo g CFR Pert 2, Subpart C, Soctkyr 2.33 and 2.36)

ITEM 1 Enter regbb'atlwr number as assigned to th8 Remarch Facility by United Sltes Deparbnont of Agriculture (USDA).

I'EM 2 - Enter the comp~ete name and addres of the Headquarters Wearch Facility as registered with USOA

I n M 3 - List Locaton of earn Fdciliv or Site where animals were housed or used In actual research, testing, teaching, or exgerirnentahn, or held far these ~ ~ W 8 . (Attached 8dUtm31 shoe& lt necessary.)

ITEM 4 -13 - DO NOT enter n u m k s In Column A. W NOT add numbers enterd in Cdurnn B inb the total in Cdumn F. Column F is to show total of numbers entered In Cdumns C + 0 + E. Entries in Column !! must be explained on attached -t(s)*

rfEM 12 List by common name all othw fann animal species.

IlEM 13 - 0 t h ~ : Uft, Sy m m o n name, al other warm blooded anlmal spedes covered by h e Regulations. (77);s will Indude dl wld orexotic specks,) Attach additional sheers If necessary or use APHIS Form 7023A

CERTIFICATIONS: Must be signed by the Chief EecutIve Officer (C.F-0.) of the Registered Research Facility or ot!ef Institutional Offiddl (1.0.) havlfig authority b legally commit on the behalf d the Registerec Resear& Facility. Slgn, Print or type Name and Title, znd Date.

R m R N COYPlETeb FORM WITH AN Ofll&)lUL SIGNATURE OF C.E.O. OR 1.0. TO APPROPRLATE SECTOR OFFCE.

USW GPHI S RC

APHIS Farm 7023 Site Ust

The following sites have been reported by the facility.

Reglst-atbn Number: 33-R-0725 Customer Number: ------- Facility: ----------- -------------- --

P 0 BOX 256 ALTAMONT, IL 6241 1 (6 1 8) 483-5333

HUELS VETERINARY SERVICES, PC NORTH MAlN ST ALTAMONT, IL 6421 1


US16 GFHI '5 GC

----------- -------------- -- P 0 BOX 256 ALTAMONT, IL 6241 1

Oear Registrant:

November 13,2002 Customer No: 9450 Cedflcate Na: 33-R-0125 RE: ANNUAL REPORT SUBMlSSION

Under the Animal Welfare Act (AWA) regulations, all active or inactive research facilities, or thocia cancelled during the Fiscal Year must file an Annual Report (APHIS Fonn 7023) with the Animal Care Regional Office dccurnent~ng their aotivities and animal usage for the Federal Fiscal Year (October 1 thmugh September 30) by December 1 of that year. Research facilities Mose re~istrations were terminated during the Fisd Year must also fulfill this requirement. Failure to do so constitutes a vioiation of the AWA and its regulation$,

We offer two methods for submission of the Annual Report (APHIS Form 7023); regular mzil or electronic submissions vla the Internet. The Animal Care web site (http:lhvww.aphis.usda.gov/ac/ ) provides insbudions for Password Application and access to submit via t he internet.

If you elect to submit via regular mail, please wrnpleie the enclosed APHIS Form 7023 and rctum the original to the address listed to the !eft. Detailad instructions are provided on the enclosed Annual Report Check List. All research facilities should complete Items 4 through 13 if applicable. Negative reports are required. Also required is the Date, Signature, and Tide of the Chief Executive Officer or other legaily responsible official who sttests to the accuracy of the report and to the assurance statements. We appreciate your prompt attention to this matter.

We appreciate your efforts in complying with the Anirnai Welfare Act. Contact this office at (919) 71 6-5532 or (91 9) 71 6-5537 if you have any questions regarding this letter or the Anirnai Welfare Act.

Sincerely,

~lizadth Galdentyer. DVM \ Regional Director - Animal Care Eastern Regional Office


Th~s re;=rt IS requred by law (7 USC 2143). Falllira tc report ac:3rding to the regulations can

See anached form for additional information

- --

VIU'TED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLANT HEALTH INSPECTION SERVICE


1. CERTIFICATE NUMBER: 33-R-0 1 26 CUSTOMER NUMBER: 9971

--7-- FORM APPROVE3 OM6 NO. G57S-0035

---- -------- -------- Joliet Junior College 1215 Houbolt Rd Joliet, IL 60431

Telephone: (8 15) -280-2775

I 3. REPORTING FACILITY ( List all locations where antmals were housed or used in actual research, testing 1. or experimentation. or held for these purposes. Attach additional sheets if necessary )

FACILIIY LOCATIONS ( Sites ) - See Atached tisting

1 REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv or use APHIS Form 7023A 1 1


Welfare Regulations

B. Number of animals being bred, conditioned. or held for use In teaching, testing, expenmenis. researtn. or

C. Numcerof anirrals upon whtch ieaching, research. expenments, or tes's were conducted involving no pain, dtstress, or

D. Number of animals upon which expenments. :eachtng. research, surpecy, or tests were conoucted involving acccmpanying pain or distress to !he anirrals and for wh~ch

E. Number of animals upon which teaching, experiments, reseam. surgery or tests were conducted involving accompanying pain or distress to tha ani.rais and fgr .Nhich the use of appropriate aneslhe!ic, analgesic, or tranquilizing drugs would have adversely affected the procedures. results, or interpretat~on of the teaching, r e read , expenments. surgety, or :ests. ( An explanation of the procedures produang pain or distress in these animals and the



I surgery but not yt I appropnate anesthetic. a I reasons such drugs were not used must be attached to I

7. Hamsters I

4. Dogs

5. Cats

a. Guinea Pigs

a. Rabbits I

I

I I

9. Non-human Primate I I I I . i0. Sheep

I

! 1. Pigs

: 2. Other F a y Animals 4rtrkZm

i 3. Other Animals I

- --- --

ASSURANCE STATEMENTS 1 1) Professionally acceptable standards governing the care, treabnent, and use of animals, induding appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and following

actual mearch, teaching. testing, surgery, or experimentation were followed by this research facility.

2) Each prinapal investigator has considered alternatives to painful procedures.

3) This faality is adhering to the standards and regulations under the Ad, and it has required that excaptions to the standards and regulations be speufied and explained by the prinapal investigator and approved by the lnstitutlonal Animal Cam and Use Committee (IACUC). A summary of all such exceptloru is attached to thls annual report In addition to identifying the IACUC-approved exteptioru, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attending veterinarian for this research facility has apprcpriate authority to ensure the provision of adequate veterinary care and to oversee the adequacy of other as- of animal care and -- -- ---

CERTIFICA~ON BY HEADQUARTERS RESEARCH FACILITY OFFICIAL- ( Chief Executive Officer or Legally Responsible lnstihrtional Official )

(AUG 91 )

DATE . SIGNED ,( 11/25/0\ A


Interagency Remrt Co & rd No.: 3; ?

Thrs report Is required by law (7 USC 2143). Failure to report according to the regulations 2002 See attached form for additional information I

UNITED STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PLAN,T HEALTH INSPECTION SERVICE

Illinois College Of Optometry Department Of Basic And Health Sciences 3241 S Michigan Ave Chicago, IL 60616

1. CERTIFICATE NUMBER: 33-R-0 127

CUSTOMER NUMBER: 1 1 54 1



Telephone: (31 2) -949-71 88

I. REPORTING FACILITY ( Ltst all locations where anirnals were housed or used in actual research, test 1. or experimentation, or held for these purposes. Attach additional sheets if necessary ) 1 FACILITY LOCATIONS ( Sites ) - See Atached Listing

) REPORT OF ANIMALS

A.

JSED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv o r use APHIS Form 7023A \

6. Numberof I an~mals being bred. cond~tioned. or held for use tn teachmg, tesbng. expenments, research. or surgery but not ye

- - -- - - - - - - -

E. Number of animals upon which teaching, C. Number of animals upon which teaching, research. experiments. or tests were conducted involving no pain, distress, or use of pain- relieving drugs.

D. Number of animals upon which experiments, teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animals and for which appropnate anesthetic, a

experiments. research. surgery or tests were conducted involving accompanying pain or distress to the animals and for which the use of appropriate


Animals Covered By The Anlmal

Welfare Regulations anesthetic. analgesic, or tranquilizing drugs would have adversely affected the procedures. results. or


interpretation of the teaching. research. experiments. surgery, or tests. ( An explanation of the procedures producing pain or distress in these antmals and the reasons such d ~ g s were not used must be attached to

5. Cats '":? I

6. Guinea Pigs <+ 7. Hamsters

8. Rabbits


10. Sheep I 1 1. Pigs

12. Other Farm Animals I I

- w 4

\ k ~ c G&+ WWC I p&C m Ls-f ~ f ~ . r / i ~---- - - - - I

ASSURANCE STATEMENTS i

1) Professionally acceptable standards governing the care, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing drugs, prior to, during, and f&dW actual research, teacfting, testing, surgery, or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be smed and explained by the principal investigator and approved by the Institutional Animal Care and Use Committee (LACUC). A summary of all such exceptions Is attached to this annual report. In addition to identrfying the IACUC-approved exceptions, this summary includes a brief explanation of the exceptions, as well as the species and number of animals affected.

4) The attendii veterinarian for this research facility has appropriate authority to ensure the provision of adequate veterinary cam and to oversee the adequacy of other aspects of animal care and

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL

APHI



I lnteragency Report Control No.: Thls report is rquired by law (7 USC 2143). Fatlure to report according to the regulations

can

UNITE0 STATES DEPARTMENT OF AGRICULTURE ANIMAL AND PUNT HEALTH INSPECTION SERVICE


CUSTOMER NUMBER: 1 234 1 I FORM APPROMD OM0 NO. 0579-0036

De Paul Universitv Academic A f f a i r s 990 West Fullerton Avenue Suite 4300 Chicago, IL 60614


Telephone: (773) -325-2593

$ I. REPORTING FAClLrPl ( List all locations where anirrrals were housed or used in actual research, tesl

+ I. or experimentation. or held for these purposes. Attach additional sheets if necessary )

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if neeessarv or use APHIS Form 702315 \

B. Number of - animals being bred. conditioned, w held for use In teaching. testmg. experlmenb. research. or surgery but not yc

- - -

C. Number d animals upon which teaching, research. experiments, or tests were conducted involving no pain. distress. or use of palm rdieving drugs.

D. Number of animals upon which experiments, teaching. research. surgery. or tests were conducted involwng accompanying pain or distress to the animals and for which appropriate anesthetic, a

E. Number of anirmls upon which teaching. experiments. research. surgery or tests were conducted involving accompanying pain or distress to the anirnals and for which the use of appropnate anesthetic. analgesic. or tranquilizing drugs would have adversely affected the procedures. results. or interpretation of the teaching. research. experiments. surgery. or tests. ( An explanation of the procedures produang pain or distress in these animals and the reasons such drugs were not used must be attached to



4. Dogs I 5. Cats I 6. Guinea Pigs I

8. Rabbits


10. Sheep I 1 1. Pigs I 12. Other Farm Animals

- --

13. Other Animals

ASSURANCE STATEMENTS I

1) Pmsiondly aocbptoble standards govwning the c ~ . InMrrmt ond use of mim~LI, inctuding appropriate use d anestetic. analgesic. end tnnquilizing drugs. prior to, during, end fol- actual rssowct~, teaching, tasting, surgery, w expdmmbtion were followed by thir research facility.

3) This Wl i is .dh.nng to the stwrdrdr md regul.tions under tho A4 .nd it has required th.1 mceptbu to ths rtpnd.rdr end regulations be spadied snd explained by the principal m a t o r md approved by the I nM ion8 l Animal Cam and Use Committee (IACUC). A summary of all such uceptlons Is attached to this annual report. In sddition b idontitying tho IACUC-apprw.6 -ions, this sumnary lncludes e brid explanation of the gccsptiom, as well as the species and n u m b of onimals &eded

CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICLAL

s ATE SIGNED

1 / 2 5 / \ 2 A

ES

922 LT

s

OL

0

9s

L'IZ

ETOT

ES

921

LT

S

OL

0

9s

LIZ

ETOT

/

I

laynb~ puno~9

sI!qJW

sel~!wu!ln

~WJy .cr - A'. "c>lJ-yQ

~W~AJaclK)ZL

&!d 'CL

daarls -0 L

WWJd WnWW -6

Wqetl '8

ualsurw -L

Interagency Report Con Bd d 0.: See attached farm for additional information

This r e v c -equtred by law (7 USC 2143). Fatlure to report accordmg to the regulations t i t . D


1. CERTIFICATE NUMBER: 33-R-0 1 30 CUSTOMER NUMBER: 17720 I FORM APPROVED

OMB NO. 0579-0036

L

3. REPORTING FACILITY ( List all locations where animals were housed or used in actual research. testing, or expenmentation. or held for these purposes. Attach additional sheets if necessary ) 1

Jersey Calhoun Veterinary 1201 S. State St. Jerseyville, IL 62502


Telephone: (6 1 8) -498-24 1 3 .

REPORT OF ANIMALS USED BY OR UNDER CONTROL OF RESEARCH FACILITY I Attach additional sheets if necessarv o r use APHIS Form 702349 \

6. Number of animals being bred. conditioned, or held for use in teaching. testing. experiments. research, or surgery but not ye

C. Nurnberof animals upon which tezching research. experiments. or tests were conducted involving no pain. distress, or use of pain- relieving drugs.

D. Number of animals upon which expe5mts. teaching. research, surgery, or tests were conducted involving accompanying pain or distress to the animls and for which appropnate anesthetic. a

E. Number of animals upon which teaching. experiments, research, surgery or tests were conduded invdvino ?cxmnpar\ying pain or distrs* to the animals and for which the use of appropriate anesthetic, analgesic, or tranquilizing drugs would have adversely affected the procedures. results, or interpretation of the teaching, research. experiments. surgery, or tests. (An explanation of the procedures producing pain or distress in these animals and the reasons such drugs were not used must be attached to

TDTXL NUMBER OF ANIMALS



4. Dogs

5. Cats

6. Guinea Pigs

7. Hamsters

8. Rabbits


10. Sheep

1 1. Pigs


13. Other Animals

) ASSURANCE STATEMENTS I J

1) Professionally acceptable stamlards governing the cam, treatment, and use of animals, including appropriate use of anestetic, analgesic, and tranquilizing d q s , prior to, during, and following actual research, teaching, testing. surgery, or experimentation were followed by this research facility.


3) This facility is adhering to the standards and regulations under the Act, and it has required that exceptions to the standards and regulations be speclf~ed and explained by the principal investigator and appmved by Vie Institutional Animal Care and Use Committee (IACUC). A summary of all such exceptions Is attached to this annual report In addition to identtfying the IACUC-approved exceptions, this summary indudes a brief explanation of the excapbons. as well the species and number of animals affected.


CERTIFICATION BY HEADQUARTERS RESEARCH FACILITY OFFICIAL ( Chief Executive Officer or Legally Responsible Institutional Official )

( AUG 91 )

DATE SIGNED

/& .if-0 Z

Documents

REPORT OF lWE RESEARCH FACILITY I Chicago, IL 60612 ...4) The attending veterinarian for this research faality has appropriate authority to ensure the provision of adequate veterinary