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Institute of Pharmacology Public transport: Nearest underground station Medical University of Vienna line U2 (purple line), station: "Schottentor – Währinger Straße 13a Universität". Walk up Währinger Straße A-1090 Vienna (about 5 min) or take trams no. 37, 40, 41 or 42 till first stop (Schwarzspanierstraße).

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) 26 - 27 November 2010

LOCATION 

REGISTRATION FEES AND ORGANISATION 

Registration Fee: € 20,-- (Please pay the registation fee at the registration desk.) Reduced registration fee for retired members of APHAR and for students with written confirmation of student status: € 10,-- Participation is free of charge for plenary speakers and for APHAR honorary members. Registration Desk: Institute of Pharmacology, Medical University of Vienna Währinger Str. 13a, A-1090 Vienna, Tel: +43 (1) 4277-64101; Fax +43 (1) 4277-9641 e-mail: michaela.gnasmueller@meduniwien.ac.at Opening hours: Fri, 26 Nov: 08:00 – 19:00 Sat, 27 Nov: 08:00 – 13:00 Language: All presentations shall be given in English Organisation: Austrian Pharmacological Society (APHAR) President: Andrea Laslop, Secretary: Michael Freissmuth

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CHAIR: Anna Bucsics, Markus Zeitlinger

  08:30  The trafficking of GPR55 is regulated by the G protein-coupled receptor   A 1  associated sorting protein-1

Julia Kargl1, Nariman Balenga1, Wolfgang Platzer1, Lene Martini2, Jennifer Whistler2 and Maria Waldhoer1 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria; 2Ernest Gallo Clinic and Research Center, University of California San Francisco, CA 94608, USA

08:45 Enhanced fear expression in a psychopathological mouse model of trait anxiety: A 5 pharmacological interventions

Markus Hauschild1, Simone B Sartori1, Mirjam Bunck2,3, Stefano Gaburro1, Rainer Landgraf2 and Nicolas Singewald1 1Department of Pharmacology and Toxicology, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria, 2Department of Behavioral Neuroendocrinology, Max Planck Institute of Psychiatry, 80804 Munich, Germany, 3Affectis Pharmaceuticals AG, 82152 Martinsried, Germany

09:00 Vertical inhibition of the mTORC1/mTORC2/PI3K pathway shows synergistic A 42 A 42 effects against melanoma in vitro and in vivo

Johannes Werzowa, Stefan Koehrer, Sabine Strommer, Daniel Cejka, Thorsten Füreder and Volker Wacheck Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

09:15 Thrombus formation is not pH-dependent A 43 Stefan Weisshaar, Ghazaleh Gouya and Michael Wolzt

Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

09:30 Is thymoquinone an antioxidant? A 9 Katrin Staniek and Lars Gille

Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria

09:45 Inhibition of tissue factor pathway inhibitor (TFPI) by ARC19499 improves clotting A 44 of hemophiliac blood

Monika E Gorczyca1, Bernd Jilma1, Christoph Male2, Sylvia Reitter3, James C Gilbert4 and Ingrid Pabinger3 1Department of Clinical Pharmacology, 2Department of Pediatrics, 3Department of Medicine I, Division of Hematology and Hemostasis, Medical University of Vienna, 1090 Vienna, Austria; 4Archemix Corp., Cambridge, MA 02142, USA

  SHORT COMMUNICATIONS 

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Friday , 26th of November, 2010

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10:00 Coffee Break CHAIR: Dagmar Stoiber-Sakaguchi, Jürgen Zezula

10:10 Structured Poster Session (Details - page 10) 5 min/Poster (A4, A6, A8, A12, A35, A36, A39, A40, A41) (3 slides, 3 min. presentation,

2 min. discussion) CHAIR: Brigitte Blöchl-Daum

11:00 Drug Discovery: Lessons from Evolution John Warren

Medical Assessor at UK Medicines Healthcare products Regulatory Agency (MHRA) and Member of EU Scientific Advice Working Party at the European Medicines Agency (EMA)

CHAIR: Sonja Sucic, Oliver Kudlacek

14:00 Endotoxin-induced microparticle formation is subject to tolerance development A 37 in humans

Daniel Nguyen, Stefan Weisshaar and Michael Wolzt Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

14:15 Small-animal PET evaluation of [11C]MC113 as a PET tracer for P-glycoprotein A 46 Severin Mairinger1,2,3, Nicola A Colabufo4, Thomas Wanek1, Claudia Kuntner1,

Johann Stanek2, Thomas Erker3, Mariangela Cantore4, Francesco Berardi4, Roberto Perrone4, Markus Müller2 and Oliver Langer1,2 1Health and Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf; 2Department of Clinical Pharmacology, Medical University of Vienna, 3Department of Medicinal Chemistry, University of Vienna, 1090 Vienna, Austria; 4Dipartimento Farmacochimico, Facoltà di Farmacia, Università degli Studi di Bari “A. Moro”, 70125 Bari, Italy

  COFFEE BREAK & STRUCTURED POSTERSESSION 1 

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Friday , 26th of November, 2010

  PLENARY LECTURE 

12:00 – 14:00  LUNCH BREAK AND FREE POSTER SESSION 

12:00  MITGLIEDERVERSAMMLUNG DER SEKTION  KLINISCHE PHARMAKOLOGIE   Assembly of the Members of the Clinical Pharmacology Section 

  SHORT COMMUNICATIONS 

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14:30 Molecular engineering of the TRPC3 pore structure identifies Ca2+ permeation A 15 through TRPC3 channels as a key determinant of cardiac calcineurin/NFAT signaling

Michaela Lichtenegger1, Hannes Schleifer1, Thomas Stockner2, Christoph Romanin3, Michael Poteser1 and Klaus Groschner1 1Institute of Pharmaceutical Sciences – Pharmacology and Toxicology, University of Graz, 8010 Graz, Austria 2Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

3Institute of Biophysics, University of Linz, 4040 Linz, Austria 14:45 Does VEGF polymorphism play a role in the treatment success with VEGF A 38 inhibitors in patients with CNV?

Agnes Boltz1, Günther Weigert2, Stefan Palkovits1, Manuel Ruiß1, Martin Weger3, Yosuf El-Shabrawi3, Gerhard Garhöfer1, Jost Jonas4 and Leopold Schmetterer1,5 1Department of Clinical Pharmacology, 2Department of Ophthalmology, 5Center of Medical Physics and Biomedical Engineering, Medical University of Vienna, 1090 Vienna, Austria

3Department of Ophthalmology, Medical University of Graz, 8036 Graz, Austria 4Department of Ophthalmology, University of Heidelberg, 69120 Mannheim, Germany CHAIR: Michael Freissmuth

15:00 Molecular networks and the mechanism of action of drugs Giulio Superti-Furga Director, CeMM Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 14, AKH BT 25.3; A-1090 Vienna, Austria 16:00 – 18:00 Coffee Break and CHAIR: Maria Waldhör, Christian Nanoff

Structured Poster Session (Details - page 12) 5 min/Poster (A10, A11, A13, A14, A16, A17, A18, A19, A20, A21, A22, A26, A28, A29, A30, A31, A32, A34, A45, A47, A48, L1)

  PLENARY LECTURE 

  COFFEE BREAK & STRUCTURED POSTERSESSION 2 

18:00  APHAR GENERAL ASSEMBLY   APHAR Members only 

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Friday , 26th of November, 2010

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Location: Heuriger WELSER Probusgasse 12 1190 Vienna (19th district) Public transport: Take tram no. 37 (see map of meeting location above) in direction "Hohe Warte" and get off at the last stop. From there walk down Hohe Warte (keeping the direction of the tram line), cross Grinzinger Straße, enter Armbrustergasse, first right is Probusgasse. Alternatively, you can take underground U4 (green line, see plan above) until last stop Heiligenstadt, then take bus no. 38A until stop Armbrustergasse.

19:30  EVENING AT A VIENNESE WINE RESTAURANT (HEURIGER) 

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Friday , 26th of November, 2010

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CHAIR: Eva-Maria Zebedin, Georg Wietzorrek

08:30 Effect of rat common carotid artery occlusion on vascular action of adenosine A 2 Miroslav Radenković1, Radmila Stevanović2, Marko Stojanović1, Mirko Topalović1 and Milica Stojiljković1 1Department of Pharmacology, Clinical Pharmacology and Toxicology, Medical Faculty, University of Belgrade, 11129 Belgrade; 2Institute of Pathology, Medical Faculty, University of Belgrade, 11000 Belgrade, Serbia 08:45 Neuropeptide Y in the basolateral amygdala modulates the acquisition of A 33 conditioned fear Ramon O Tasan1, Dilip Verma1, Herbert Herzog2 and Günther Sperk1 1Institute of Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria

2Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia

09:00 Cross-talk of PGD2 receptors: the DP receptor modulates signaling and trafficking A 7 of CRTH2 Miriam Sedej, Wolfgang Platzer, Ákos Heinemann and Maria Waldhoer

Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria

09:15 Resveratrol reduces myofibroblast arrhythmogenicity A 3 Christian Rosker, Nicolò Salvarani and Stephan Rohr Department of Physiology, University of Bern, 3012 Bern, Switzerland 09:30 Altered sodium channel function in dystrophin/utrophin-deficient cardiomyocytes A 25 Xaver Koenig1, Agnes Mike1, Markus Mille1, René Cervenka1, Péter Lukács1,

Katrin Nagl1, Xuan Bach Dang1, Hannes Todt1, Reginald E Bittner2 and Karlheinz Hilber1 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Neuromuscular Research Department, Center for Anatomy and Cell Biology, Medical University of Vienna, 1090 Vienna, Austria

09:45 Conformation of membrane-inserted P-glycoprotein A 27 Thomas Stockner1,2, Harald H Sitte1 and Peter Chiba2 1Institute of Medical Chemistry, Medical University of Vienna, 1090 Vienna, Austria

2Institute of Pharmacology, Centre of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

10:00 – 10:30 Coffee Break and Free Postersession

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Saturday , 27th of November, 2010

  SHORT COMMUNICATIONS 

  COFFEE BREAK & FREE POSTERSESSION 

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CHAIR: Eva-Maria Zebedin, Georg Wietzorrek

10:30 A molecular switch between the outer and the inner vestibules of the voltage- A 23 gated Na+ channel

René Cervenka, Péter Lukács, Touran Zarrabi, Xaver Koenig, Agnés Mike, Karlheinz Hilber and Hannes Todt Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

10:45 The permanently charged lidocaine analogue QX222 acts as a blocker from the A 24 intracellular side and as an inactivation modulator from the extracellular side in a

mutant NaV1.4 channel Péter Lukács, René Cervenka, Xaver Koenig, Agnés Mike, Touran Zarrabi, Karlheinz Hilber and Hannes Todt Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

11:00 The Hans Horst Meyer Award of the Austrian Pharmacological Society is awarded to young investigators in experimental and clinical pharmacology and toxicology. Donated by Corporation Austria. H.H. MEYER (1853–1939) 11:20 The Heribert Konzett Award of the Austrian Pharmacological Society is awarded to young investigators in experimental and clinical pharmacology in recognition of their independent research achievements. Donated by Austria. H. KONZETT (1912–2004) 12:00 Insights into migraine mechanisms from mouse models of familial hemiplegic migraine. Daniela Pietrobon Department of Biomedical Sciences, University of Padova, 35121, Padua, Italy

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Saturday , 27th of November, 2010

  SHORT COMMUNICATIONS 

  HANS HORST MEYER AWARD 2010 

  HERIBERT KONZETT AWARD 2010 

  EPHAR LECTURE          CHAIR: Alexandra Koschak, Thomas Griesbacher 

13:00  END OF MEETING 

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CHAIR: Dagmar Stoiber-Sakaguchi, Jürgen Zezula A 4 A ligand-based 3D pharmacophore model for the μ opioid receptor: application to the morphinan class of opioids

Muhammad Faheem Asim, Gerhard Wolber, Mariana Spetea and Helmut Schmidhammer Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences, University of Innsbruck, 6020 Innsbruck, Austria

A 6 The interplay of excitatory and inhibitory coupling modes is crucial for the regulation of neuronal electrical activities by L-type calcium channels

Petra Geier, Michael Lagler, Stefan Boehm and Helmut Kubista Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

A 8 Signalling and function of the human G protein-coupled receptor 55

Nariman Balenga1, Julia Kargl1, Ralf Schröder2, Ákos Heinemann1, Evi Kostenis2 and Maria Waldhoer1 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria 2Section of Molecular, Cellular and Pharmacobiology, Institute for Pharmaceutical Biology, University of Bonn, 53115 Bonn, Germany

A 12 Long term regulation of ATP-binding cassette transporters on mRNA and protein level by simvastatin in human rhabdomyosarcoma and neuroblastoma cells

Bihter Atil1, Martin Werner1, Evelyn Sieczkowski1, Peter Chiba2 and Martin Hohenegger1 1Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Institute of Medical Chemistry, Medical University of Vienna, 1090 Vienna, Austria

A 35 Short-chain methotrexate polyglutamate MTXPG2 as outcome parameter in rheumatoid arthritis

Eva-Luise Hobl1, Bernd Jilma1, Ludwig Erlacher2 and Robert Mader3 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Rheumatology, Kaiser-Franz-Josef-Spital, 1100 Vienna, Austria 3Department of Internal Medicine I, Medical University of Vienna, 1090 Vienna, Austria

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) Friday , 26th of November, 2010

  STRUCTURED POSTER PRESENTATION (SESSION 1) 

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A 36 Teicoplanin pharmacokinetics during albumin dialysis

Stefan Weiler1, Gerda Falkensammer2, Christoph Seger2, Michael Joannidis3 and Romuald Bellmann1,3 1Clinical Pharmacokinetics Unit, Laboratory of Inflammation Research, Department of Internal Medicine I, Innsbruck Medical University, 6020 Innsbruck, Austria 2Central Institute for Medical and Chemical Laboratory Diagnostics, Innsbruck General Hospital, 6020 Innsbruck, Austria 3Intensive Care Unit, Department of Internal Medicine I, Innsbruck Medical University, 6020 Innsbruck, Austria

A 39 Antimicrobial activity of antibiotics in urine under different physiological conditions

Angela Burian, Zeynep Erdogan, Mohammad Manafi and Markus Zeitlinger Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

A 40 The influence of lutein supplementation on macular pigment optical density in patients with dry AMD compared with healthy control subjects Semira Kaya1, Günther Weigert2, Nikolaus Dragostinoff3, René Werkmeister3,

Berthold Pemp1,2, Stefan Sacu2, Gerhard Garhöfer1, Ursula Schmidt-Erfurth2 and Leopold Schmetterer1,3 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Ophthalmology, Medical University of Vienna, 1090 Vienna, Austria 3Center for Biomedical Engineering and Physics, Medical University of Vienna, 1090, Vienna, Austria A 41 BEZ235 impairs gastric cancer growth by inhibition of PI3K/mTOR in vitro and in vivo

Thorsten Füreder1, Thomas Wanek2, Pamina Pflegerl3, Agnes Jaeger-Lansky1, Doris Hoeflmayer1, Sabine Strommer1, Claudia Kuntner2, Markus Müller1, Oliver Langer1,2 and Volker Wacheck1 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Health and Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria 3Department of Pathology, Medical University of Vienna, 1090 Vienna, Austria

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CHAIR: Maria Waldhör, Christian Nanoff A 10 Toxicity of ascaridole from Chenopodium ambrosioides in mammalian mitochondria

Lars Gille1, Lianet Monzote2, Werner Stamberg1 and Katrin Staniek1 1Molecular Pharmacology and Toxicology Unit, Department of Biomedical Sciences, University of Veterinary Medicine, 1210 Vienna, Austria 2Institute of Tropical Medicine “Pedro Kouri”, 11500 Havana City, Cuba

A 11 Concentrative ER export of the serotonin transporter relies exclusively on an interaction with Sec24C

Sonja Sucic1, Ali El-Kasaby1, Subhodeep Sarker1, Harald H Sitte1, Philippe Marin2 and Michael Freissmuth1 1Institute of Pharmacology, Center for Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Institut de Génomique Fonctionnelle, CNRS UMR 5203, INSERM U661, Universités Montpellier I & II, 34094 Montpellier Cedex 5, France

A 13 Interactions of peripheral and central opioid systems during emotional stress

Valentina Bashkatova1,3, Helmut Prast2, Alexei Umriukhin1 and Sergey Sudakov1,3 1Department of Reinforcement Physiology, P.K. Anokhin Research Institute of Normal Physiology RAMS, 125315 Moscow, Russia 2Department of Pharmacology and Toxicology, University of Innsbruck, 6020 Innsbruck, Austria 3Department of Addictive Physiology, Institute of Human Morphology RAMS, 119217 Moscow, Russia

A 14 Effects on cell proliferation and EPR spin trapping studies of Abnormal Savda Munziq and its chromatographic subfractions

Klaus Stolze1, Adiljan Ablimit2 and Alois Strasser3 1Department of Biomedical Sciences, Molecular Pharmacology and Toxicology, University of Veterinary Medicine Vienna, 1210 Viena, Austria 2Xinjiang Medical University, Urumqi 830054, Xinjiang, China 3Department of Biomedical Sciences, Institute of Physiology, University of Veterinary Medicine Vienna, 1210 Vienna, Austria

A 16 Interaction of manganese with striatal dopamine turnover in human alphasynuclein transgenic mice

Tamara M Peneder1, Michael Berger1, Petra Scholze1, Georg Heinze2, Johanna Bertl2, Jan Bauer1, Oleh Hornykiewicz1, Eric K Richfield3 and Christian Pifl1 1Center for Brain Research, Medical University of Vienna, 1090 Vienna, Austria 2Core Unit for Medical Statistics and Informatics, Medical University of Vienna, 1090 Vienna, Austria 3Environmental and Occupational Health Science Institute, Piscataway, NJ 08854, USA

A 17 A biological target for antiplatelet therapy: the prostaglandin E2 receptor EP4

Sonia Philipose, Martina Ofner, Ákos Heinemann and Rufina Schuligoi Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria

  STRUCTURED POSTER PRESENTATION (SESSION 2) 

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A 18 The role of the carboxyl terminus in folding of the serotonin transporter

Ali El-Kasaby, Herwig Just, Harald Sitte, Oliver Kudlacek and Michael Freissmuth Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

A 19 Calmodulin kinase II regulates amphetamine-induced reverse transport in the dopamine transporter: implications for the importance of the dopamine transporter in Angelman Syndrome

Thomas Steinkellner1, Oliver Kudlacek1, Michael Freissmuth1, Ype Elgersma2 and Harald Sitte1 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Neuroscience, Erasmus University Medical Center, 3015 GE Rotterdam, The Netherlands

A 20 α-N-Heterocyclic thiosemicarbazones induce ER stress-mediated CHOP activation

Robert Trondl1, Christian R Kowol1, Vladimir B Arion1,2, Michael A Jakupec1,2 and Bernhard K Keppler1,2 1Institute of Inorganic Chemistry, University of Vienna, 1090 Vienna, Austria 2Research Platform “Translational Cancer Therapy Research”, University of Vienna, 1090 Vienna, Austria

A 21 The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter

Subhodeep Sarker1, René Weissensteiner2, Ilka Steiner1, Harald H Sitte1, Gerhard F Ecker2, Michael Freissmuth1 and Sonja Sucic1 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Medicinal Chemistry, University of Vienna, 1090 Vienna, Austria

A 22 4-Methylthioamphetamine (4-MTA) induces mitochondrial-dependent apoptosis in SH-SY5Y cells independently of dopamine and noradrenaline transporters

Therese Montgomery1, Harald Sitte1 and Gethin McBean2 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland

A 26 The interactome of the A2A adenosine receptor in vitro and in vivo

Christian Bergmayr, Christian Nanoff, Oliver Kudlacek and Christian Gruber Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

A 28 Selective serotonin reuptake inhibitor-induced cell death: in search of a mechanism

Christina Glöckel1, Christoph Minichsdorfer1, Gerhard F Ecker2 and Michael Freissmuth1 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Medicinal Chemistry, University of Vienna, 1090 Vienna, Austria

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A 29 The pulmonary microvascular endothelial barrier function is controlled by the PGE2-EP4 signaling axis

Viktória Kónya1, Andreas Üllen2, Eva M Sturm1, Petra Luschnig1, Wolfgang Sattler2 and Ákos Heinemann1 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria 2Institute of Molecular Biology and Biochemistry, Medical University of Graz, 8010 Graz, Austria

A 30 Tracking the A2A adenosine receptor

Patrick Thurner, Simon Keuerleber, Ingrid Gsandtner, Michael Freissmuth, Jürgen Zezula Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria

A 31 Luminescence resonance energy transfer-based intramolecular distances measurements in leucine transporter from Aquifex aeolicus

Azmat Sohail1, Peggy Stolt-Bergner2, Gerhard F Ecker3, Michael Freissmuth1, Harald Sitte1 and Walter Sandtner1 1Institute of Pharmacology, Center of Physiology and Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Research Institute of Molecular Pathology, Campus Vienna Biocenter, 1030 Vienna, Austria 3Department of Medicinal Chemistry, University of Vienna, 1090 Vienna, Austria

A 32 Endogenous dynorphin in emotional control and stress response revisited

Christoph Schwarzer1, Christian Lutsch1, Eduard Schunk1, Iris Kastenberger1 and Herbert Herzog2 1Institute of Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria 2Neuroscience Research Program, Garvan Institute of Medical Research, Darlinghurst NSW 2010, Australia

A 34 Fear learning triggers structural changes at GABAergic synapses in the basal amygdala

Yu Kasugai1, Markus Hauschild2, Werner Sieghart3, Ryuichi Shigemoto4, Nicolas Singewald2, Francesco Ferraguti1 1Department of Pharmacology, Innsbruck Medical University, 6020 Innsbruck, Austria 2Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Innsbruck, 6020 Innsbruck, Austria 3Department of Biochemistry and Molecular Biology, Medical University of Vienna, 1090 Vienna, Austria 4Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Aichi, 444-8585, Japan

A 45 Tissue pharmacokinetics of individual macrolides support observed differences in development of bacterial resistance

Shaip Krasniqi1, Peter Matzneller1, Martina Kinzig2, Sven Hüttner2, Fritz Sörgel2, Markus Müller1 and Markus Zeitlinger1 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Institute for Biomedical and Pharmaceutical Research, 90562 Nürnberg- Heroldsberg, Germany

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A 47 Dose-response assessment of tariquidar for inhibition of P-glycoprotein at the human blood-brain barrier using (R)-[11C]verapamil PET

Martin Bauer1, Markus Zeitlinger1, Peter Matzneller1, Johann Stanek1, Edith Lackner1, Wolfgang Wadsak2, Markus Müller1 and Oliver Langer1,3 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Department of Nuclear Medicine, Medical University of Vienna, 1090 Vienna, Austria 3Health and Environment Department, Molecular Medicine, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria

A 48 Heterogeneous penetration of cefpirome and moxifloxacin into abscesses after simultaneous administration in humans

Robert Sauermann1, Thomas Feurstein1, Rudolf Karch2, Andreas Püspök3, Herbert Langenberger4, Walter Jäger5, Michaela Böhmdorfer5, Thomas Wild6, Stefan Winkler7, Maria C Kjellsson8, Markus Zeitlinger1 1Department of Clinical Pharmacology, Medical University of Vienna, 1090 Vienna, Austria 2Center for Medical Statistics, Informatics and Intelligent Systems, Medical University of Vienna, 1090 Vienna, Austria 3Department of Gastroenterology, Medical University of Vienna, 1090 Vienna, Austria 3Department of Gastroenterology, Medical University of Vienna, 1090 Vienna, Austria 3Department of Gastroenterology, Medical University of Vienna, 1090 Vienna, Austria 4Department of Diagnostic Radiology, Medical University of Vienna, 1090, Vienna, Austria 5Clinical Pharmacy and Diagnostics, University of Vienna, 1090 Vienna, Austria 6Department of Surgery, Paracelsus Medical University, 5020 Salzburg, Austria 7Division of Infectious Diseases and Tropical Medicine, Medical University of Vienna, 1090 Vienna, Austria 8Department of Pharmaceutical Biosciences, Uppsala University, 75124,Uppsala, Sweden

L 1 Cyanate transforms HDL into a pro-atherogenic lipoprotein Michael Holzer1, Martin Gauster2, Veronika Binder1, Dalia El-Gamal1, Christian Wadsack3, Rufina Schuligoi1, Ákos Heinemann1 and Gunther Marsche1 1Institute of Experimental and Clinical Pharmacology, Medical University of Graz, 8010 Graz, Austria 2Department of Cell Biology, Histology and Embryology, Medical University of Graz, 8010 Graz, Austria 3Department of Obstetrics and Gynecology, Medical University of Graz, 8036 Graz, Austria

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Austrian Pharmacological Society (APHAR): Executive Committee:

President: Andrea Laslop (Vienna), Vice-President: Peter Holzer (Graz), Secretary: Michael Freissmuth (Vienna), Treasurer: Barbara Valenta (Vienna), President of the Clinical Pharmacology Section: Brigitte Blöchl-Daum (Vienna), Further Member: Reiner Fischer-Colbrie (Innsbruck).

Clinical Pharmacology Section Committee: President: Brigitte Blöchl-Daum (Vienna), Vice-President: Bernd Jilma (Vienna), Further Member: Markus Zeitlinger (Vienna).

ZVR-Zahl: 202359700 Website: http://www.aphar.at/ Supporting Members of APHAR:

The EPHAR Lecture is supported by the Federation of European Pharmacological Societies (sponsored by the British Pharmacological Society)

16th Scientific Symposium of the Austrian Pharmacological Society (APHAR) 26 - 27 November 2010

Poster_APHAR2010_A4_mit_MUWAPHAR_PROGRAMM_2010_DRUCK.pdf