Regenerative medicine changes the world - WHITE PAPERwrecoin.org/assets/pdf/whitepaper.pdf · 2018. 9. 20. · Japan Regeneration Medicine Association(JRMA) and has a tie-up relationship

- WHITE PAPER -

Regenerative medicine changes the world

Table of contents

2

■RBC project …3

■Regenerative medicine using stem cells …4

■Types and characteristics of stem cells …5

■"Stem cell regeneration treatment" and target diseases …6

■Medical Corporation Yushikai …7

■Number of diabetics in the world …8

■Improvement cases of "diabetes” & "liver dysfunction" …9

■Purpose of ICO …10

■ Token sale outline …11

■Token allocation & Use of funds …12

■Details of RBC Project …13

■Organization chart of RBC Project …14

■Roadmap …15

■About ICO & Potential risk …16

Our company is a bio venture company that agrees with the idea of the

Japan Regeneration Medicine Association(JRMA) and has a tie-up

relationship.

In Japan's regenerative medicine, according to legitimate procedures, we

are starting to provide stem cell therapy in various medical institutions

including the Yusikai, a member of the Japanese Society for Regenerative

Medicine.

In addition to diabetes and liver dysfunction, treatment was performed on

immunological diseases, and results such as partial remission (symptomatic

improvement state), complete remission (symptoms disappeared and

examination numerical values also indicate normal), and results such as

progress stop has been obtained, and it has proved to be highly effective.

This result shows that we can spread the stem cell therapy in earnest and

hope that many patients will receive treatment for diseases that have been

difficult to treat until now. At the same time, development of stem cell

treatment technology will be further advanced using AI technology. In

addition, we will promote the development of new drugs to obtain approval

for medicines.

This time, we will spread cutting-edge stem cell therapy technology to the

world and conduct ICO to become a new standard of medical care.

By using the RBC project to optimize treatment costs, we also use block

chain technology to protect customer information with a high security

level, and connect medical institutions offering stem cell therapy to patients

who wish to treat this treatment.

It is a project that combines cutting-edge stem cell therapy and cutting-

edge block-chain technology.

RBC project

3

Regenerative medicine using stem cells

The human body consists of about 60

trillion cells, and each cell has a role

determined by the function of the body

such as muscles and nerves. However,

there are special cells that do not have a

definite role and can change into various

cells.

It is "stem cells". "Stem cells" have the

ability to repair or regenerate cells and

tissues that have become unable to perform

their intended function by disease.

"Stem cell regeneration treatment" aims at

improving the condition by extracting

"stem cells" from adipocytes collected

from patients, culturing them and

administering them again to patients.

"Stem cells" extracted from own fat,

therefore, there is no possibility of

rejection is very reliable and highly safe

treatment methods.

In modern times medical care has advanced highly. However, on the other hand, lifestyle-related diseases such as diabetes, heart disease, stroke, hypertension,obesity and hyperlipemia continue to increase. These diseases were difficult to treat completely and the ' Symptomatic treatment ' was the main focus.

However, the future era is not going to cure after getting sick, but "prevention

medicine" which prevents in advance and makes a healthy life expectancy is

changing to the center world.

This RBC project is a cutting-edge treatment in the field of "stem cell

regeneration therapy".

Now, regenerative medicine is the most noteworthy field in the medical industry,

and continues to advance and develop rapidly, and new results around the world

are picked up every day.

Regenerative medicine is a way of treating cells and tissues and will open up a

new path to treatment for diseases that have been difficult to treat until now.

4

Types and characteristics of stem cells

Fertilized egg

Totipotent stem cell The ability to produce any kind of cell is called

"omnipotence", and having this ability is the "source of life"

that can be all cells, such as fetus and placenta, with only

about two weeks 'fertilized eggs' from right after

fertilization.

Embryonic Stem cell; Stem

cells within the early embryo

of fertilized ovum. It is

possible to become all cells,

research progress, but

practical application is

difficult from the ethical

problem. It is not carried out

to a person. ES cells (embryonic stem cells)

Pluripotent stem cells

iPS cells

Induced pluripotent stem cells induced Pluripotent Stem cell;

It is currently in the process of

being studied and has not been

carried out to people.

Somatic stem cells

Mesenchymal stem cells

Chondrocytes, tenocytes, osteoblasts,

muscle cells, cardiomyocytes,

hepatocytes, adipocytes,

glial cells, nerve cells,

fibroblasts,

vascular endothelial cells, etc.

Self-derived and highly safe (medical technology provided in this project)

Glial cells

Nerve cell

Neural stem cells Hematopoietic stem cells

Erythrocyte

White blood cell

platelet

Vascular endothelial stem cells

Vascular

endothelial cells

Hepatic stem cells

Hepatocytes

Epithelial system stem cells

Skin

Mucosal

epithelium

Somatic stem cells are stem cells that exist in many parts of our body. It is thought that there is

no ability to differentiate because the role is fixed, but it is known that "mesenchymal stem cells"

in the bone marrow have "differentiation ability" to become various cells. In a more recent study,

"fat-derived mesenchymal stem cells" It has been revealed that it has "differentiation ability."

Since adipose origin is easy to collect and abundant in quantity, it is being rapidly put into

practical use as a medical technology that can be utilized for realistic stem cell regeneration

treatment. Many clinical prescriptions for people are also being implemented.

5

In the relationship between aging and stem cells, when the neonate is taken as 1, in

the 80s, the number of tissue stem cells in the bone marrow has decreased to 1/200

of the newborn, that is, the decrease in stem cells has been found to be a cause of

aging .

"Stem cell regeneration treatment" is

to improve the disease condition by

increasing the number of stem cells

in the body by extracting "stem

cells" from adipocytes collected

from patients, culturing them and

administering them to the patient

himself again .

Immune disease

atopic

Atopic dermatitis

Alcohol urticaria

Allergic constitution

Sjogren's syndrome

Chemical hypersensitivity

Brain / neurological

diseases

Ethambutol visual neurosis

Facial paralysis

Cluster headache

Autonomic imbalance

Nerve sequelae

Hearing loss

Disc herniation

Epilepsy

Brainstem bleeding

Brain stem bleeding

sequelae

cerebral infarction

Cerebral infarction

sequelae

cerebral hemorrhage

Brain tumor

Tinnitus

Spinal stenosis

Metabolic disease

Diabetes

High fat thrombus

Renal dysfunction

Kidney disease

ventilation

Chronic renal failure

Neurodegenerative disease

ALS

Alzheimer's disease

Cerebral palsy

Parkinson's disease

Chronic axilloscopy

neuropathy

Respiratory disease

COPD

Bronchiectasis

asthma

Pulmonary suppuration

Exercise system / trauma

Tough damaging

Muscle

Lumbar spondylosis

Low back pain

Cervical spinal canal

stenosis

Tuberculous spinal caries

Malignant tumor

Malignant lymphoma

Stomach cancer

Liver cancer

Pleural mesothelioma

Esophageal cancer

Prostate cancer

Colon cancer

After ovarian cancer

surgery

Other

Menopause

sarcoidosis

Postpartum depression

Periodontal disease

Pressure sores

Prostatic hypertrophy

Male menopause

Wrist joint pain

Graves' disease

Behcet's disease

Glaucoma

Gastrointestinal disease

Liver dysfunction

Liver disease

Liver dysfunction

Reflux esophagitis

Enteritis

Constipation

Chronic gall bladder

Abnormality of

confluence of

pancreatobiliary

Cardiovascular disease

Acute myocardial

infarction

Angina pectoris

Hypertension

arrhythmia

Atrial septal defect

Idiopathic atrial

fibrillation

6

"Stem cell regeneration

treatment" and target diseases

Medical Corporation Yushikai

http://www.hellodc.net/pdf/hello_pdf01.pdf

Chief Director Yasushi:

Yasushi ChoMedical Corporation Yushikai

Wing Hello Dental / Medical Clinic

Treatment of diabetes using autologous adipose-derived stem cells

Plan number: PB7170014 (accepted)

Wing Hello Dental / Medical Clinic is an accredited medical institution that

officially obtains regenerative treatment of stem cells by acquiring the

provisional plan number of Type 2 Regenerative Medicine etc. for the

treatment of diabetes based on formal procedures to the Ministry of Health,

Labor and Welfare.

Yushikai is the world's first clinic in Japan that acquired a plan number from

the Ministry of Health, Labor and Welfare for regenerative medicine for the

treatment of diabetes.

7

This data summarizes the World Diabetes Union (IDF).

From the IDF data, the world suffers from diabetes at a rate of one out of

eleven people.

Diabetic patients are estimated to be 425 million in 2017, and 700 million

in 30 years.

Number of diabetics in the world

Country/Territory People with diabetes

China 114394.82

India 72946.39

United States of America 30187.48

Brazil 12465.83

Mexico 12030.06

Indonesia 10276.12

Russian Federation 8455.3

Egypt 8222.64

Germany 7476.8

Pakistan 7474.03

Japan 7234.23

Bangladesh 6926.26

Turkey 6694.46

Iran (Islamic Republic of) 4985.53

Thailand 4208.59

Saudi Arabia 3851.99

Philippines 3721.91

Spain 3584.53

Viet Nam 3535.69

http://www.diabetesatlas.org/

1st place China about 114 million people2nd place India about 73 million people3rd place Americans about 30 million people4th place Brazil about 12.5 million people5th place Mexico about 12 million people6th place Indonesia about 10 million people

In the top six places, three countries are located in Asia, and the number of people in the world is close to half a billion of diabetics.We aim to enhance the clinic and the culture facilities which are able to receive treatment for the patient in the world suffering from the diabetic which is considered to be an incurable disease in this way.

8

9

Improved cases of "diabetes & "liver dysfunction”

Currency code RBC

Purpose of ICO

All funds raised are for the development of the RBC project.

1.Enriching domestic / overseas clinics and culture facilities

2.Developing your own wallet

3.Optimize cost of stem cell therapy by expanding business

4.Pharmacy of stem cell therapy

5.Client support using block chain technology and optimization of stem cell

therapy using AI

6.Construction of a platform that can purchase health foods and cosmetics

7.Development of health management application and wearable terminal

10

Token name Rebirth Coin

Currency code RBC

Number issued 120,000 RBC

Type ERC20

Token Sales Price 1BTC＝25RBC

1ETH＝1RBC

Maximum number of tokens sold 60,000 RBC

※1RBC = about $300

Token sale outline

Phase1 2018

10/1～10/20

Distribution of

tokens

December 2018

20%Bonus

Phase2 2018

10/21～11/10

10%Bonus

Phase3 2018

11/11～11/30

5%Bonus

For example, if you buy 1 RBCs on October 1, you will get 0.2 RBCs for 20%, so you own a

total of 1.2 RBCs.

* Token sale out issuance limit Upper limit of 60,000 RBC is sold out, the token sale will end at

that point.

* The contents of the schedule may change depending on the progress of the project.

* Bonus content will be held for 6 months after distribution.

* For team reservations, we will lock you for one year after the sale ends.

* We will lock you for one year after using RBC.

Payment is accepted as Bitcoin / Ethereum. These are virtual currencies that are

circulated globally. We will change the legal currency once to these currencies and

purchase RBC.

The total number of issued RBCs shall be 120,000 RBC, and the maximum number

of issuance of selling at the time of token sale shall be 60,000.

Only if it does not reach the expected amount of funds procurement, it shall incinerate

(burn) the market distribution minute token for the unachieved amount of

procurement and then incinerate (burn) the same token from the team's holding.

For that reason, the market distribution token quantity and the team / development

token quantity are the same value and the balance is kept without being biased.

Also, during the token sale the following time bonus (distribution of tokens as a

predecessor privilege) will be applied.

Treatment cost 2% discountAdministration under 3,000 times

Treatment cost 3% discountAdministration over 3,000 times


Over 1 RBC holders benefits







11

35%

30%

20%

10%

5%Expansion and research ofhospital facilities

System development

Marketing

Legal compliance

Management cost

12

Token allocation & Use of funds

50%

15%

35%Token sale

Token bonus

Team ownership

Token Sales Participants can distribute up to 50% of the number of copies issued.

This treatment can be expected to have a variety of effects, including anti-aging and diabetes.

Although stem cell therapy is currently attracting worldwide attention, it is the only five

countries in the world that can perform stem cell therapy in the United States,

Germany ,Switzerland, Russia (government agencies) and Japan.

In particular, as the demand for stem cell therapy rises in Asia, there are only Japan to be

accepted in neighboring countries. Companies and organizations that introduce Chinese

patients to overseas hospitals are born. The Japan has many benefits, such as being able to

access a medical residency visa from China.

In partnership with Chinese Travel Companies

Stem Cell Therapy's inbound service to Japan, centering on the Yushikai,

which is the only clinic in Japan that can perform regenerative medicine for

the purpose of diabetes treatment, starts.

As a saucer for this inbound service, we plan to install new culture facilities and

medical facilities, and we can expect the inflow of funds to regenerative medicine

on a global scale by using the RBC settlement by our own wallet.

Details of RBC Project

13

・Optimization of the cost of stem cell therapy

・Pharmaceutical treatment of stem cells

・Build a platform to purchase health food and cosmetics

・Development of health management application and wearable terminal

・Optimization of stem cell therapy using block chain technology, client support and AI

Based on the user's own

medical data, we propose a

supplement, household medical

equipment, cosmetics, health

food, and food materials to the

user, using big data such as diet

and exercise that are

accumulated on a daily basis.

Wearable devices visualize

your health and keep your

health data safe on the block

chain.

The daily health data will help

you manage your own health

and treat you at this project

partner clinic.

By using block chain technology,

we prevent leakage of client

information and enhance support

after treatment.

In addition, we aim to establish

the best stem cell therapy for the

symptoms by using AI

technology for the accumulation

of data by many treatments.

Stem cell therapy is a new

treatment that can be expected

to be effective for a variety of

symptoms. However, one-time

treatment is a high-millions-

tens treatment. Therefore, it is

the present situation that the

person who can receive this

treatment is limited

By conducting research and

clinical studies of therapeutic

formulations utilizing stem

cells and distributing them, we

aim to "optimize the cost of

stem cell therapy and become

a pharmaceutical".

The project aims to deliver the

regenerative medicine to many

people, to achieve the optimal

cost of treatment.

Organization chart of RBC project

14

Medical Corporation Yushikai

Tokyo Clinic Opening Schedule

Travel package for stem cell

therapy by

Chinese Travel Companese

Opening of Macau S.A.R. Clinic

Diabetes Regenerative Medicine Institute

Japan Regeneration Medicine Association

Roadmap

2018 2019 2020 2021 2022 2023 2024 2025

-PC CSS

Development

(Note 1)

-Development of

EC site platform

-Development and

implementation of

health promotion

applications

-Stabilization of the

management of medical

institutions

- Partnering with stem cell

clinics for beauty


clinics for immune diseases


clinics for skin diseases

- Spread of payment system

- Development of original

Wallet

-Development of

Japan and Asian city

Clinic

-Increase in culture

facilities

-EC Site

Platform

implementation

-Wearable

development

-Wearable

implementation

-CSS

Implementation

(Note1) PC：Private Chain

CSS：Client Support System

15

About ICO & Potential risks

Risk of losing access to this token due to loss of private key

Regulatory risksRisk by force

majeure

The private key is required to receive this token stored in the purchaser's digital wallet.Thus, loss of the private key of the digital wallet in which the purchaser's token is stored may result in loss of this token.

It is not always possible to predict how each regulatory authority will apply or apply the current regulations for the technology and use of this token.If regulatory or legal changes are illegal to operate in that jurisdiction, the law may cease to operate in that jurisdiction.

ICO and our success are influenced by a number of factors. As a result, the value of the RBC may fluctuate. The reasons may be affected by circumstances such as economic conditions, virtual currency token market conditions, political circumstances, war, natural disasters, or other unforeseen situations.

16

ICO (Initial Coin offering) is a technique for raising money by issuing and selling your own digital tokens.It is not a form of equity transfer, as in stock procurement, but as well as a purchase-type crowdfunding, which simply sells tokens.This token is not recognized as a "virtual currency" at the time of sale.In other words, ICO is not a "fund-raising" method, but rather a "token sales method" on a strict definition, and the purchaser of the token is not the "investor" who invests in the project. At the present time, the RBC token is not intended to be used as a payment of consideration to unspecified persons, and the exchange market with legal currency, bitcoin and other existing cryptographic currencies is not present.The above definition is also considered to be true for this ICO project.

What is ICO?

Although ICO's funding was only 36 million in the first quarter of 2017, in the second quarter, ICO's funding for the block chain was 790 million (22 times the previous quarter). It became clear that VC's investment in this field was significantly above 230 million million.The procurement amount Top10 all issuers have raised more than 5 billion yen and are expected to be in further growth markets in the future.The market capitalization of the entire virtual currency is surged this year in parallel with the growth rate of ico, and topped 170 billion dollars.Mount Gox has also overcome barriers such as embezzlement and closure of the Chinese exchange, and is actively trading today.

About ICO Market

The Plaza Commercial Centre Level 8, Suite 5,

Bisazza Street Sliema SLM1640, Malta

Reblo Co.,Ltd.

Documents

Regenerative medicine changes the world - WHITE PAPERwrecoin.org/assets/pdf/whitepaper.pdf · 2018. 9. 20. · Japan Regeneration Medicine Association(JRMA) and has a tie-up relationship