REFEREED JOURNALS & BOOKS & PATENTS

1. Albergoni V., Cobelli C., Torresin G.: Interaction model between circulatory and respiratory system. IEEE

Trans. on Biomed. Eng. BME-19: 108-113, 1972.

2. Cobelli C., Frezza M., Tiribelli C.: Modeling, identification and parameter estimation of bilirubin kinetics in

normal, hemolytic and system Gilbert's states. Comput. Biomed. Res. 8: 522-537, 1975.

3. Cobelli C., Romanin Jacur G.: Structural identifiability of strongly connected biological compartmental

systems. Med. Biol. Eng. 13: 831-838, 1975.

4. Cobelli C., Salvan A.: A medical record and a computer program for diagnosis of thyroid diseases. Meth. Infor.

Med. 14: 126-132, 1975.

5. Cobelli C., Romanin Jacur G.: Controllability, observability and structural identifiability of multi- input multi-

output biological compartmental systems. IEEE Trans. Biomed. Eng. BME- 23: 93-100, 1976.

6. Cobelli C., Romanin Jacur G.: On the structural identifiability of biological compartmental systems in a general

input-output configuration. Math. Biosci. 30: 139-151, 1976.

7. Cobelli C., Salvan A.: Parameter estimation in a biological two compartment model. A computer experimental

study of the influence of the initial estimate in the parameter space and of the model representation. Math.

Biosci. 33: 51-62, 1977.

8. Cobelli C., Polo A., Romanin Jacur G.: A computer program for the analysis of controllability, observability

and structural identifiability of biological compartmental systems. Comput. Progr. Biomed. 7: 21-36, 1977.

9. Cobelli C., Salvan A.: Parameter estimation in a biological two compartment model. II: A computer

experimental study of the influence of the initial estimate in the parameter space, of some sampling protocols

and of weighting factors. Math. Biosci. 37: 267-274, 1977.

10. Campello L., Cobelli C.: Parameter estimation of biological stochastic compartmental models. An application.

IEEE Trans. Biomed. Eng. BME-25: 139-146, 1978.

11. Cobelli C., Rescigno A.: Some observations on the physical realizability of compartmental models with delays.

IEEE Trans. Biomed. Eng. BME-25: 294-295, 1978.

12. Cobelli C., Lepschy A., Romanin Jacur G.: Comments on "On the relationship between structural identifiability

and the controllability, observability properties". IEEE Trans. Autom. Contr. AC-23: 965-966, 1978.

13. Cobelli C., Morato L.: On the identification by filtering techniques of a biological n-compartment model in

which the transport rate parameters are assumed to be stochastic processes. Bull. Math. Biol. 40: 651-660, 1978.

14. Bossi A., Cobelli C., Colussi L., Romanin Jacur G.: A method of writing symbolically the transfer matrix of a

compartmental model. Math. Biosci. 43: 187-198, 1979.

15. Cobelli C., Lepschy A., Romanin Jacur G.: Identifiability of compartmental systems and related structural

properties. Math. Biosci. 44: 1-18, 1979.

16. Bergman R.N., Ider Y.Z., Bowden C.R., Cobelli C.: Quantitative estimation of insulin sensitivity. Am. J.

Physiol. 236: E667 -677, 1979.

17. Cobelli C., Lepschy A., Romanin Jacur G.: Identifiability results on some constrained compartmental systems.

Math.Biosci. 47: 173-195, 1979.

18. Cobelli C., Pacini G., Salvan A.: On a simple model of insulin secretion. Med. Biol. Eng. Comput. 18: 457-463,

1980.

19. DiStefano J.J. III, Cobelli C.: On parameter and structural identifiability: nonunique

reconstructiability/observability for identifiable systems, other ambiguities and new definitions. IEEE Trans.

Autom. Contr. AC-25: 830-833, 1980.

20. Toffolo G., Bergman R.N., Bowden C.R., Cobelli C.: Quantitative estimation of Beta-cell sensitivity to glucose

in the intact organism. Diabetes 29: 979-990, 1980.

21. Cobelli C., DiStefano J.J. III: Parameter and structural identifiability concepts and ambiguities: a critical review

and analysis. Am. J. Physiol. 239: R7-R24, 1980.

22. Bossi A., Cobelli C., Romanin Jacur G., Livio Colussi: Transfer function matrix of a compartmental model.

Comput. Progr. Biomed. 12: 141-155, 1980.

23. Bergman R.N., Cobelli C.: Minimal modeling, partition analysis and the estimation of insulin sensitivity. Fed.

Proc. 39: 110-115, 1980.

24. Cobelli C., Lepschy A., Romanin Jacur G.: Identifiability in tracer experiments. Fed. Proc. 39: 91-96, 1980.

25. Bossi A., Colussi L., Cobelli C., Romanin Jacur G.: Identifiability of compartmental models: algorithms to

solve an actual problem by means of symbolic calculus. ACM SIGSAM Bulletin 14: 35-40, 1980.

26. Bergman R.N., Cobelli C., Toffolo G.: Minimal model of glucose/insulin dynamics in the intact organism. A

novel approach for evaluation of factors controlling glucose tolerance. Trans. Inst. Meas. Control 3: 207-216,

1981.

27. Albergoni V., Cobelli C., Lepschy A.: Compartmental systems. An appealing class for kinetic modeling and

identification of metabolic processes. Toxicol. Environm. Chem. 4, 297-336, 1981.

28. Okolicsanyi L., Orlando R., Venuti M., Dal Brun G., Cobelli C., Ruggeri A., Salvan A.: A modeling study of

the effect of fasting on bilirubin kinetics in Gilbert's syndrome. Am. J. Physiol. 240: R266-R271, 1981.

29. Carson E.R., Cobelli C., Finkelstein L.: Modeling and identification of metabolic systems. Am. J. Physiol. 240:

R120-R129, 1981.

30. Bergman R.N., Phillips L.S., Cobelli C.: Physiologic evaluation of factors controlling glucose tolerance in man.

Measurement of insulin sensitivity and B-cell glucose sensitivity from the response to intravenous glucose. J.

Clin. Invest. 68, 1456-1467, 1981.

31. Cobelli C., Finkelstein L., Carson E.R.: Mathematical modelling of endocrine and metabolic systems: model

formulation, identification and validation. Mathematics and Computers in Simulation XXIV, 442-451, 1982.

32. Nosadini R., Del Prato S., Tiengo A., Duner E., Toffolo G., Cobelli C., Faronato P., Moghetti P., Muggeo M.:

Insulin sensitivity, binding and kinetics in pancreatogenic and type I diabetes. Diabetes 31: 346-355, 1982.

33. Cobelli C., Nosadini R., Toffolo G., McCulloch A., Avogaro A., Tiengo A., Alberti K.G.M.M.: Model of the

kinetics of ketone bodies in humans. Am. J. Physiol. 243: R7-R17, 1982.

34. Cobelli C., Federspil G., Pacini G., Salvan A., Scandellari C.: An integrated mathematical model of the

dynamics of blood glucose and its hormonal control. Math. Biosci. 58: 27-60, 1982.

35. Cobelli C., Ruggeri A.: Evaluation of alternative model structures of metabolic systems. Two case studies on

model identification and validation. Med. Biol. Eng. Comput. 20: 444-450, 1982.

36. Cobelli C., DiStefano J.J.III, Ruggeri A.: Minimal sampling schedule for identification of dynamic models of

metabolic systems of clinical interest: case studies for two liver function tests. Math. Biosci. 63: 173-186, 1983.

37. Cobelli C., Ruggeri A.: Evaluation of portal/peripheral route and of algorithms for insulin delivery in the

closed-loop control of glucose in diabetes. A modeling study. IEEE Trans. Biomed. Eng. BME-30: 93-103,

1983.

38. Cobelli C., Mari A.: Validation of mathematical models of complex endocrine-metabolic systems. A case study

on a model of glucose regulation. Med. Biol. Eng. Comput. 21: 390-399, 1983.

39. Cobelli C., Ruggeri A., Toffolo G., Avogaro A., Nosadini R.: Is the "pool fraction" paradigm a valid model for

assessment of in vivo turnover in non-steady state? Am. J. Physiol. 245: R624-R633, 1983.

40. Del Prato S., Nosadini R., Tiengo A., Tessari P., Avogaro A., Trevisan R., Valerio A., Muggeo M., Cobelli C.,

Toffolo G.: Insulin-mediated glucose disposal in Type-I diabetes. Evidence for insulin resistance, J. Clin.

Endocrin. Metab. 57: 904-910, 1983.

41. Cobelli C.: Modeling and identification of endocrine-metabolic systems. Theoretical aspects and their

importance in practice. Math. Biosci. 72:263-289, 1984.

42. Cobelli C., Carson E.R., Finkelstein L., Leaning M.S.: The validation of simple and complex models in

physiology and medicine. Am. J. Physiol. 246: R259-R266, 1984.

43. Cobelli C., Toffolo G.: Compartmental vs noncompartmental modeling for two accessible pools. Am. J.

Physiol. 247: R488-R496, 1984.

44. Cobelli C., Toffolo G.: Identifiability from parameter bounds. Structural and numerical aspects. Math. Biosci.

71: 237-243, 1984.

45. Cobelli C., Toffolo G., Ferrannini E.: A model of glucose kinetics and their control by insulin. Compartmental

and noncompartmental approaches. Math. Biosci. 72: 291-315, 1984.

46. Cobelli C., Pacini G.: Physiological modelling for better interpreting dynamic test data: estimation of insulin

sensitivity. Scand. J. Clin. Lab. Invest. 44, Suppl. 171: 193-210, 1984.

47. Cobelli C., Mari A., Duner E., Mollo F., Nosadini R.: On the estimation of absorption of subcutaneous injected

insulin from plasma concentrations using mathematical models. Diabetologia 26: 314-316, 1984.

48. Cobelli C., Thomaseth K.: Optimal input design for identification of compartmental models. Theory and

application to a model of glucose kinetics. Math. Biosci. 77: 267-286, 1985.

49. Cobelli C., Ruggeri A., DiStefano J.J. III, Landaw E.M.: Optimal design of multioutput sampling schedule -

Software and applications to endocrine-metabolic and pharmacokinetic models. IEEE Trans. Biomed. Eng.

BME-32: 219-256, 1985.

50. Ferrannini E., Smith D.J., Cobelli C., Toffolo G., Pilo A., DeFronzo R.A.: Effect of insulin on the distribution

and disposition of glucose in man. J. Clin. Invest. 76: 357-364, 1985.

51. Cobelli C., Mari A.: Control of diabetes with artificial systems for insulin delivery - Algorithm independent

limitations revealed by a modelling study. IEEE Trans. Biomed. Engng. BME-32: 840-845, 1985.

52. Nosadini R., Avogaro A., Trevisan R., Duner E., Marescotti C., Iori E., Cobelli C., Toffolo G.: Acetoacetate and

3- hydroxybuty-rate kinetics in obese and insulin-dependent diabetic humans. Am. J. Physiol. 248:R611-R620,

1985.

53. Nosadini R., Avogaro A., Sacca' L., Vigorito C., de Kreutzenberg S., Cobelli C., Toffolo G., Trevisan R.,

Tessari P., Tiengo A., Crepaldi G.: Ketone body metabolism in normal and diabetic human skeletal muscle.

Am. J. Physiol. 249: E131 -136, 1985.

54. Cobelli C., Lepschy A., Romanin Jacur G., Viaro U.: L'analisi compartimentale: uno strumento efficace per i

problemi di modellizzazione in vari campi applicativi. Ricerca Operativa 36: 69-90, 1985.

55. Cobelli C., Pacini G., Toffolo G., Sacca' L.: Estimation of insulin sensitivity and glucose clearance from

minimal model: new insights from labelled IVGTT. Am. J. Physiol. 250: E591-598, 1986.

56. Cobelli C., Lepschy A., Romanin Jacur G., Viaro U.: An expanded schematic for compartmental systems. Math.

Biosci 79: 97-106, 1986.

57. Cobelli C., Lepschy A., Romanin Jacur G., Viaro U.: Symbolic expression of transfer functions in

compartmental systems with control. Int. J. of System Sci. 17: 925-935, 1986.

58. Cobelli C., Lepschy A., Romanin Jacur G., Viaro U.: Compartmental graphs accounting for smoothing,

integration and differentiation. J. Franklin Inst. 321:179-188, 1986.

59. Cobelli C., Lepschy A., Romanin Jacur G., Viaro U.: On the relationship between Forrester's schematics and

compartmental graphs. IEEE Trans. System, Man and Cyber. SMC-16: 723-726, 1986.

60. Cobelli C., Mari A., Ferrannini E.: On linearity of insulin kinetics. Am. J. Physiol. 251: E247 -248, 1986.

61. Ferrannini E., Cobelli C.: The kinetics of insulin in man. I General aspects. II Role of the liver. Diab. Metab.

Rev. 3: 335-363 and 365-397, 1987.

62. Nosadini R., Angelini C., Trevisan C., Vigili de Kreutzenberg S., Fioretto P., Trevisan R., Avogaro A., De

Dona C., Doria A., Cobelli C., Toffolo G.: Glucose and ketone body turnover in carnitine-palmitoyl-transferase

deficiency. Metabolism 36: 821-826, 1987.

63. Cobelli C., Thomaseth K.: The minimal model of glucose disappearance: optimal input studies. Math. Biosci.

83: 127-155, 1987.

64. Cobelli C., Mari A., Del Prato S., De Kreutzenberg S., Nosadini R., Jensen I.: Reconstructing the rate of

appearance of subcutaneous insulin by deconvolution. Am. J. Physiol. 253:E584 -590, 1987.

65. Cobelli C., Mari A., Ferrannini E.: Non-steady state: error analysis of Steele's model and developments for

glucose kinetics. Am. J. Physiol. 252:E679 -689,1987.

66. Cobelli C., Toffolo G., Bier D., Nosadini R.: Models to interpret kinetic data in stable isotope tracer studies.

Am. J. Physiol. 253:E551 -564, 1987.

67. Smith D., Rossetti L., Ferrannini E., Johnson C.M., Cobelli C., Toffolo G., Katz L.D., DeFronzo R.: In vivo

glucose metabolism in the avake rat: tracer and insulin clamp studies. Metabolism 36: 1167-1174, 1987.

68. Cavallo-Perin P., Bruno A., Cobelli C., Pacini G., Niort G., Boine L., Goria M., Pagano G.: Insulin sensitivity

in subacute experimental T3 hyperthyroidism in man. Horm. Metabol. Res. 20: 186-187, 1988.

69. Cobelli C., Pacini G.: Insulin secretion and hepatic extraction in humans by minimal modeling of C-peptide and

insulin kinetics. Diabetes 37: 223-231, 1988.

70. Cobelli C., Thomaseth K.: On optimality of the impulse input for linear system identification. Math. Biosci. 89:

127-133, 1988.

71. Cobelli C., Thomaseth K.: Optimal equidose inputs and role of measurement error for estimating the parameters

of a compartmental model of glucose kinetics from continuous- and discrete-time optimal samples. Math.

Biosci. 89: 135-147, 1988.

72. Galli G., Maini C.L., Orlando P., Cobelli C., Thomaseth K., Deleide G., Valle G.: A radiopharmaceutical for the

study of the liver: 99m-Tc-DTPA-Asialo-orosomucord II: Human dynamic and imaging studies. J. Nucl. Med.

& All. Sci. 32: 117-126, 1988.

73. Pacini G., Valerio A., Beccaro F., Nosadini R., Cobelli C., Crepaldi G.: Insulin sensitivity and Beta-cell

responsivity are not decreased in elderly subjects with normal OGTT. J. Am. Geriatr. Soc. 36: 317-323, 1988.

74. Nosadini R., DeKreutzenberg S., Duner E., Iori E., Avogaro A., Trevisan R., Fioretto P., Doria A., Merkel C.,

Cobelli C., Mari A., Jensen I., Heding L., Crepaldi G.: Porcine and human insulin absorption from subcutaneous

tissues in normal and insulin-dependent diabetic subjects: a deconvolution-based approach. J. Clin. Endocrinol.

Metab. 67: 551-559, 1988.

75. Avogaro A., Bristow J.D., Bier D.M., Cobelli C., Toffolo G.: Stable-label intravenous glucose tolerance test

minimal model. Diabetes 38:1048-1055, 1989.

76. Cobelli C., Ruggeri A.: Optimal design of sampling schedules for studying glucose kinetics with tracers. Am. J.

Physiol. 257: E444 -450, 1989.

77. Cobelli C., Saccomani M.P., Ferrannini E., DeFronzo R.A., Gelfand R., Bonadonna R.: A compartmental model

to quantitate in vivo glucose transport in the human forearm. Am. J. Physiol. 257: E943-958, 1989.

78. Bellavere F., Thomaseth K., Cobelli C., Balzani I., DeMasi G., Guarini L., Bax G., Fedele D.: Evaluation of the

vagal-sympathetic interaction in diabetics with autonomic neuropathy through power spectrum density analysis

of the heart rate. A critical revision of the natural history of diabetic autonomic neuropathy is possible.

Functional Neurology 4: 177-181, 1989.

79. Cobelli C., Saccomani M.P.: Unappreciation of a priori identifiability in software packages causes ambiguities

in numerical estimates. Am. J. Physiol. 21: E1058-1059, 1990.

80. Cobelli C., Toffolo G.: Constant specific activity allows reconstruction of endogenous glucose concentration in

non steady state. Am. J. Physiol. 258: E1037 -1040, 1990.

81. Cobelli C., Toffolo G., Avogaro A., Nosadini R.: On the measurement of ketone body turnover. Am. J. Physiol.

258: E890, 1990.

82. Des Rosiers C., Montgomery J.A., Garneau M., David F., Mamer O.A., Daloze P., Toffolo G., Cobelli C.,

Landau B., Brunengraber H.: Pseudoketogenesis in hepatectomized dogs. Am. J. Physiol. 258: E519-528, 1990.

83. Marchesini G., Pacini G., Bianchi G.P., Patrono D., Cobelli C.: Glucose disposal, Beta-cell secretion, and

hepatic insulin extraction in cirrhosis: a minimal model assessment. Gastroenterology 99: 1715-1722, 1990.

84. Pacini G., Cobelli C.: Estimation of B-cell secretion and insulin hepatic extraction by the minimal modelling

technique. Comp. Methods Programs Biom. 32: 241-248, 1990.

85. Thomaseth K., Cobelli C., Bellavere F., Balzani I., De Masi G., Bax G., Carenza P.: Heart rate spectral analysis

for assessing autonomic regulation in diabetic patients. J. Autonom. Nerv. Syst. 30: S169-172, 1990.

86. Avogaro A., Nosadini R., Doria A., Fioretto P., Velussi M., Vigorito C., Sacca' L., Toffolo G., Cobelli C.,

Trevisan R., Duner E., Razzolini R., Rengo F., Crepaldi G.: Myocardial metabolism in insulin-deficient diabetic

humans without coronary artery disease. Am. J. Physiol. 258: E606-618, 1990.

87. Cobelli C., Ruggeri A.: A reduced sampling schedule for estimating the parameters of the glucose minimal

model from a labelled IVGTT. IEEE Trans. Biomed. Eng. BME-38: 1023-1029, 1991.

88. Cobelli C., Saccomani M.P.: Accessible pool and system parameters: assumptions and models. J. Parent. and

Ent. Nutr. 15: 45S-50S, 1991.

89. Cobelli C., Saccomani M.P., Tessari P., Biolo G., Luzi L., Matthews D.E.: Compartmental model of leucine

kinetics in humans. Am. J. Physiol. 261: E539 -550, 1991.

90. Cobelli C., Saccomani M.P.: Domain of validity of classical models of leucine metabolism assessed by

compartmental modeling. Math. Biosci. 107: 3-20, 1991.

91. Matthews D.E., Cobelli C.: Leucine metabolism in man: lessons from modeling. J. Parent. and Ent. Nutr. 15:

86S-89S, 1991.

92. Caumo A., Giacca A., Morgese M., Pozza G., Micossi P., Cobelli C.: Minimal models of glucose

disappearance: lessons from the labelled IVGTT. Diabetic Medicine 8: 822-832, 1991.

93. Cobelli C., Toffolo G., Foster D.: Tracer-to-tracee ratio for analysis of stable isotope tracer data: link with radio-

active kinetic formalism. Am. J. Physiol. 262: E968-975, 1992.

94. Sacca' L., Toffolo G., Cobelli C.: V-A and A-V modes in whole body and regional kinetics: domain of validity

from a physiological model. Am. J. Physiol. 262: E597-606, 1992.

95. Bellavere F., Balzani I., De Masi G., Carraro M., Carenza P., Cobelli C., Thomaseth K.: Power spectral analysis

of heart-rate variations improves assessment of diabetic cardiac autonomic neuropathy. Diabetes 41: 633-640,

1992.

96. Saccomani M.P., Cobelli C.: Qualitative experiment design in physiological system identification. IEEE Control

Systems Magazine 12: 18-23, 1992.

97. Brunetti P., Cobelli C., Cruciani P., Fabietti P.G., Filippucci F., Santeusanio F.: A simulation study on a self-

tuning portable controller of blood glucose. The International Journal of Artificial Organs 16: 51-57, 1993.

98. Foster D.M., Barret P.H.R., Toffolo G., Beltz W.F., Cobelli C.: Estimating the fractional synthetic rate of

plasma apolipoproteins and lipids from stable isotope data. Journal of Lipid Research 34: 2193-2205, 1993.

99. Butler P., Caumo A., Zerman A., O'Brien P., Cobelli C., Rizza R.: Methods for assessment of the rate of onset

and offset of insulin action during nonsteady state in humans. Am. J. Physiol. 264: E548-560, 1993.

100. Katz H., Butler P., Homan M., Zerman A., Caumo A., Cobelli C., Rizza R.: Hepatic and extrahepatic insulin

action in humans: measurement in the absence of non-steady-state error. Am. J. Physiol. 264: E561-566, 1993.

101. Bonadonna R., Del Prato S., Saccomani M.P., Bonora E., Gulli G., Ferrannini E., Bier D., Cobelli C., DeFronzo

R.: Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes. J.

Clin. Invest. 92: 486-494, 1993.

102. Baura G., Foster D., Porte D.Jr., Kahn S., Bergman R., Cobelli C., Schwartz M.: Saturable trasport of insulin

from plasma into the central nervous system of dogs in vivo. J. Clin. Invest. 92: 1824-1830, 1993.

103. Caumo A., Cobelli C.: Hepatic glucose production during the labeled IVGTT: estimation by deconvolution with

a new minimal model. Am. J. Physiol. 264: E829-841, 1993.

104. Bonadonna R., Saccomani M.P., Cobelli C.: Effect of insulin on system A amino acid trasport in human skeletal

muscle. J. Clin. Invest. 91: 514-521, 1993.

105. Bonadonna R., Saccomani M.P., Seely L., Zych K., Ferrannini E., Cobelli C., DeFronzo R.: Glucose transport

in human skeletal muscle: the in vivo response to insulin. Diabetes 42:191- 198, 1993.

106. Bonadonna R., Saccomani M.P., Cobelli C.: In vivo glucose transport in human skeletal muscle: tools, problems

and perspectives. Bailliere's Clinical End. and Metab. 7: 929-960, 1993.

107. Saccomani M.P., Cobelli C.: A minimal input-output configuration for a priori identifiability of a

compartmental model of leucine metabolism. IEEE Trans. Biomed. Eng. 40:797-803, 1993.

108. Toffolo G., Foster D., Cobelli C.: Estimation of protein fractional synthetic rate from tracer data. Am. J.

Physiol. 264: E128-135, 1993.

109. Caumo A., Zerman A., Rizza R., Cobelli C.: The dual tracer time-varying volume method for measuring hepatic

glucose release in nonsteady state: theoretical and simulation results. Comp. Meth. Progr. Biomed. 41: 243-267,

1994.

110. Cefalu W.T., Wagner J.D., Bell-Farrow A.D., Wang Z.Q., Adams M.R., Toffolo G., Cobelli C.: The effects of

hormonal replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys. Am. J.

Obstet. Gynecol. 171: 440-445, 1994.

111. Dobbins R.L., Davis S.N., Neal D.W., Cobelli C., Cherrington A.D.: Pulsatility does not alter the response to a

physiological increment in glucagon in the conscious dog. Am. J. Physiol. 266: E467-478, 1994.

112. Foster D.M., Barrett P.H., Bell B.M., Beltz W.F., Cobelli C., Golde H., Jacquez J.A., Phair R.D.: SAAM II:

simulation, analysis, and modeling software. Biomed. Eng. Soc. Bulletin 18: 19-21, 1994.

113. Katz H., Homan M., Jensen M., Caumo A., Cobelli C., Rizza R.: Assessment of insulin action in NIDDM in the

presence of dynamic changes in insulin and glucose concentration. Diabetes 43:289-296, 1994.

114. Vettor R., Macor C., Rossi E., De Palo C., Ruggeri A., Cobelli C., Federspil G.: Effect of naltrexone treatment

on insulin secretion, insulin action and postprandial thermogenesis in obesity. Horm. Metab. Res. 26: 188-194,

1994.

115. Alzaid A., Dinneen S., Turk D., Caumo A., Cobelli C., Rizza R.: Assessment of insulin action and glucose

effectiveness in diabetic and nondiabetic humans. J. Clin. Invest. 94: 2341-2348, 1994.

116. Dobbins R.L., Davis S.N., Neal D.W., Cobelli C., Jaspan J., Cherrington A.D.: Compartmental modeling of

glucagon kinetics in the conscious dog. Metabolism 44: 452-459, 1995.

117. Muller M.J., Reynard C.A., Burger A.G., Toffolo G., Cobelli C., Ferrannini E.: Kinetic analysis of thyroid

hormone action on glucose metabolism in man. Eur. J. Endocrinol. 132:413-418, 1995.

118. Caumo A., Homan M., Katz H.K., Cobelli C., Rizza R.: Glucose turnover in presence of changing glucose

concentrations: error analysis for glucose disappearance. Am. J. Physiol. 269: E557-567, 1995.

119. Toffolo G., De Grandi F., Cobelli C.: Estimation of beta cell sensitivity from intravenous glucose tolerance test

C-peptide data. Diabetes 44: 845-854, 1995.

120. Saccomani M.P., Bonadonna R., Caveggion E., DeFronzo R.A., Cobelli C.: [14C]bicarbonate kinetics in

humans: identification and validation of a three-compartment model. Am. J. Physiol. 269: E183-192, 1995.

121. Monti L.D., Brambilla P., Stefani I., Caumo A., Magni F., Poma R., Tomasini L., Agostini G., Galli-Kienle M.,

Cobelli C., Chiumello G., Pozza G.: Insulin regulation of glucose turnover and lipid levels in obese children

with fasting normoinsulinaemia. Diabetologia 38: 739-747, 1995.

122. Sparacino G., and Cobelli C.: A stochastic deconvolution method to reconstruct insulin secretion rate after a

glucose stimulus. IEEE Trans. Biom. Eng. 42:512-529, 1996.

123. Avogaro A.P., Vicini P., Valerio A., Caumo A., Cobelli C.: The hot but not the cold minimal model allows

precise assessment of insulin sensitivity in NIDDM subjects. Am. J. Physiol. 33:E532-540, 1996.

124. Caumo A., Vicini P., and Cobelli C.: Is the minimal model too minimal? Diabetologia, 39:997-1000, 1996.

125. Sparacino G., and Cobelli C.: Reconstruction of insulin secretion by deconvolution: Domain of validity of a

monoexponential impulse response model. Technology and Health Care 4:87-95, 1996.

126. Saccomani M.P., Bonadonna R., Bier D.M., De Fronzo R.A., and Cobelli C.: A model to measure insulin

effects on glucose transport and phosphorylation in muscle: a three-tracer study. Am. J. Physiol., 33:E170-185,

1996.

127. Zachwieja J.J., Toffolo G., Cobelli C., Bier D.M., and Yarasheski K.E.: Resistance exercise and growth

hormone administration in oder men: effects on insulin sensitivity and secretion during a stable-label

intravenous glucose tolerance test. Metabolism 45:254-260, 1996.

128. Avogaro A., Toffolo G., Miola M., Valerio A., Tiengo A., Cobelli C., Del Prato S.: Intracellular lactate- and

pyruvate-interconversion rates are increased in muscle tissue of non-insulin-dependent diabetic individuals. J.

Clin. Invest. 98:1-8, 1996.

129. Basu A., Alzaid A., Dinneen S., Caumo A., Cobelli C., Rizza R.: Effects of a change in the pattern of insulin

delivery on carbohydrate tolerance in diabetic and nondiabetic humans in the presence of differing degrees of

insulin resistance. J. Clin. Invest. 97:2351-2361, 1996.

130. Taylor R., Magnusson I., Rothman D.L., Cline G.W., Caumo A., Cobelli C., Shulman G.I.: Direct assessment of

liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis

after a mixed meal in normal subjects. J. Clin. Invest. 97:126-132, 1996.

131. Bonadonna R.C., Del Prato S., Bonora E., Saccomani M.P., Gulli G., Natali A., Frascerra S., Pecori N.,

Ferrannini E., Bier D., Cobelli C., De Fronzo R.A.: Roles of glucose transport and glucose phosphorylation in

muscle insulin resistance of NIDDM. Diabetes 45: 915-925, 1996.

132. Avogaro A., Toffolo G., Valerio A., Cobelli C.: Epinephrine exerts opposite effects of peripheral glucose

disposal and glucose-stimulated insulin secretion. Diabetes 45: 1373-1378, 1996.

133. Avogaro A., Piarulli F., Valerio A., Miola M., Calveri M., Pavan P., Vicini P., Cobelli C., Tiengo A., Cal L.,

Del Prato S.: Forearm nitric oxide balance, vascular relaxation and glucose metabolism in non-insulin

dependent diabetic patients. Diabetes 46: 1040-1046, 1997.

134. Basu A., Caumo A., Bettini F., Gelisio A., Alzaid A., Cobelli C., Rizza R.: Impaired basal glucose effectiveness

in NIDDM-Contribution of defects in glucose disappearance and production, measured using an optimized

minimal model independent protocol. Diabetes 46: 421-432, 1997.

135. Cobelli C., Vicini P., Caumo A.: If the minimal model is too minimal, who suffers more: SG or SI?

Diabetologia 40: 362-363, 1997.

136. De Nicolao G., Sparacino G., Cobelli C.: Nonparametric input estimation in physiological systems: problems,

methods, case studies. Automatica 33: 851-870, 1997.

137. Gastaldelli A., Schwarz J.M, Caveggion E., Traber L.D., Traber D.L., Rosenblatt J., Toffolo G., Cobelli C.,

Wolfe R.R.: Glucose kinetics in interstitial fluid can be predicted by compartmental modeling. Am. J. Physiol.

272: E494-505, 1997.

138. Lowe N.M., Shames D.M., Woodhouse L.R., Matel J.S., Roehl R., Saccomani M.P., Toffolo G., Cobelli C.: A

compartmental model of zinc metabolism in healthy women using oral and intravenous stable isotope tracers.

Am. J. Clin. Nutr. 65: 1810-1819, 1997.

139. Macor A., Ruggeri A., Mazzonetto P., Federspil G., Cobelli C., Vettor R.: Visceral adipose tissue impairs

insulin secretion and insulin sensitivity but not energy expenditure in obesity. Metabolism: 46: 123-129, 1997.

140. Monti L.D., Brambilla P., Caumo A., Magni F., Omati S., Nizzoli G., di Natale B., Galli-Kienle M., Cobelli C.,

Chiumello G., Pozza G.: Glucose turnover and insulin clearance after growth hormone treatment in girls with

Turner's syndrome. Metabolism 46: 1482-1488, 1997.

141. Sparacino G., Cobelli C.: Impulse response model in reconstruction of insulin secretion by deconvolution. Role

of input design in the identification experiment. Ann. Biomed. Eng. 25: 398-416, 1997.

142. Sparacino G., Vicini P., Bonadonna R.C., Marraccini P., Lehtovirta M., Ferrannini E., Cobelli C.: Removal of

catheter distortion in multiple indicator dilution studies: a deconvolution-based method and case studies on

glucose blood-tissue exchange. Med. Biol. Eng. Comp. 35: 337-342, 1997.

143. Utriainen T., Nuutila P., Takala T., Vicini P., Ruotsalainen U., Rnnemaa T., Tolvanen T., Raitakari M.,

Haaparanta M., Kirvel O., Cobelli C., Yki-Jarvinen H.: Intact insulin stimulation of skeletal muscle blood flow,

its heterogeneity and redistribution but not of glucose uptake in non-insulin dependent diabetes mellitus. J. Clin.

Invest. 100: 777-785, 1997.

144. Vicini P., Bonadonna R.C., Utriainen T., Nuutila P., Raitakari M., Yki-Jarvinen H., Cobelli C.: Estimation of

blood flow heterogeneity distribution in human skeletal muscle from positron emission tomography. Ann.

Biomed. Eng. 25: 906-910, 1997.

145. Vicini P., Caumo A., Cobelli C.: The hot IVGTT two compartment minimal model: indices of glucose

effectiveness and insulin sensitivity. Am. J. Physiol. 273: E1024-1031, 1997.

146. Vicini P., Cobelli C.: Parameter estimation in distributed models of blood-tissue exchange: a Monte Carlo

strategy to assess precision of parameter estimates. Ann. Biomed. Eng. 25: 815-821, 1997.

147. Vicini P., Sparacino G., Caumo A., Cobelli C.: Estimation of endogenous glucose production after a glucose

perturbation by nonparametric stochastic deconvolution. Computer Meth. Progr. Biomed. 52: 147-156, 1997.

148. Cobelli C., Caumo A.: Using what is accessible to measure that which is not: necessity of model of system.

Metabolism 47: 1009-35, 1998.

149. Bonadonna R.C., Saccomani M.P., Del Prato S., Bonora E., DeFronzo R.A., Cobelli C.: Role of tissue-specific

blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle. Circulation 98:

234-41, 1998.

150. Steinmueller T., Konrad T., Vicini P., Toffolo G., Jonas S., Tullius S., Bechstein W.O., Cobelli C., Usadel K.H.,

Neuhaus P.: Effect of CsA versus FK 506 on insulin sensitivity and insulin response using a modeling

technique. Transplant. Proc. 30: 1452-3, 1998.

151. Laine H., Knuuti M.J., Ruotsalainen U., Utriainen T., Oikonen V., Raitakari M., Luotolahti M., Kirvela O.,

Vicini P., Cobelli C., Nuutila P., Yki Jarvinen H.: Preserved relative dispersion but blunted stimulation of mean

flow, absolute dispersion, and blood volume by insulin in skeletal muscle of patients with essential

hypertension. Circulation 97: 2146-2153, 1998.

152. Dudley M.A., Burrin D.G., Wykes L.J., Toffolo G., Cobelli C., Nichols B.L., Rosenberger J., Jahoor F., Reeds

P.J.: Protein kinetics determined in vivo with a multiple-tracer, single-sample protocol: application to lactase

synthesis. Am. J. Physiol. 274: G591-598, 1998.

153. Caumo A., Cobelli C.: Minimal model estimate of glucose effectiveness: role of the minimal model volume and

of the second hidden compartment. Am. J. Physiol. 274: E573-576, 1998.

154. Barrett P.H., Bell B.M., Cobelli C., Golde H., Schumitzky A., Vicini P., Foster D.M.: SAAM II: Simulation,

Analysis, and Modeling Software for tracer and pharmacokinetic studies. Metabolism 47: 484-92, 1998.

155. Vicini P, Bonadonna R.C., Lehtovirta M., Groop L., Cobelli C.: Estimation of blood flow heterogeneity in

human skeletal muscle using intravascular tracer data: importance for modeling transcapillary exchange. Ann.

Biomed. Eng. 26: 764-774, 1998.

156. Vicini P., Barrett P.H.R., Cobelli C., Foster D.M., Schumitzky A.: Approaches to population kinetic analysis

with application to metabolic studies. Adv. Exp. Med. Biol. 445: 103-113, 1998.

157. Avogaro A., Valerio A., Vicini P., Toffolo G., Varagnolo C., Tiengo A., Cobelli C.: A modeling approach to

quantify the direct ketogenic effect of ethanol in humans. Nutrition Research 18: 1521-1532, 1998.

158. Audoly S., D'Angio' L., Saccomani M.P., Cobelli C.: Global identifiability of linear compartmental models. A

computer algebra algorithm. IEEE Trans. Biomed. Eng. 45: 36-41, 1998. 159. Sparacino G., Bonadonna R., Steinberg H., Baron A., Cobelli C.: Estimation of organ transport function from

recirculating indicator dilution curves. Ann. Biomed. Eng. 26: 128-137, 1998.

160. Bertoldo A., Vicini P., Sambuceti G.M., Lammertsma A.A., Parodi O., Cobelli C.: Evaluation of compartmental

and spectral analysis models of [18F]FDG kinetics for heart and brain studies with PET. IEEE Trans. Biomed.

Eng. 45: 1429-1448, 1998.

161. Cobelli C., Bettini F., Caumo A, Quon M.J.: Overestimation of minimal model glucose effectiveness in

presence of insulin response is due to undermodeling. Am. J. Physiol. 275: E1031-1036, 1998.

162. Cobelli C., Foster D.M.: Compartmental models: theory and practice using the SAAM II software system. Adv.

Exp. Med. Biol. 445: 79-101, 1998.

163. Dobbins R.L., Davis S.N., Neal D., Caumo A., Cobelli C., Cherrington A.D.: Rates of glucagon activation and

deactivation of hepatic glucose production in conscious dogs. Metabolism 47: 135-142, 1998.

164. Nielsen M.F., Basu R., Wise S., Caumo A., Cobelli C., Rizza R.A.: Normal glucose-induced suppression of

glucose production but impaired stimulation of glucose disposal in type 2 diabetes: Evidence for a

concentration-dependent defect in uptake. Diabetes 47: 1735-1747, 1998.

165. Cobelli C., Caumo A., Omenetto M.: Minimal model SG overestimation and SI underestimation: improved

accuracy by a Bayesian two-compartment model. Am. J. Physiol. 277: E481-488, 1999.

166. Caumo A., Vicini P., Zachwieja J.J., Avogaro A., Yarasheski K., Bier D.M., Cobelli C.: Undermodeling affects

minimal model indexes: insights from a two-compartment model. Am. J. Physiol. 276: E1171-1193, 1999.

167. Fabris L., Jemmolo R.M., Toffolo G., Paleari D., Viaggi S., Rigon M., Casagrande F., Lirussi F., Strazzabosco

M., Cobelli C., Okolicsanyi L.: The monoethylglycinexylidide test for grading of liver cirrhosis. Aliment.

Pharmacol. Ther. 13: 67-75, 1999.

168. Konrad T., Vicini P., Kusterer K., Hoflich A., Assadkhani A., Bohles H.J., Sewell A., Tritschler H.J., Cobelli

C., Usadel K.H.: Alpha-Lipoic acid treatment decreases serum lactate and pyruvate concentrations and improves

glucose effectiveness in lean and obese patients with type 2 diabetes. Diabetes Care 22: 280-287, 1999.

169. Thomaseth K., Cobelli C.: Generalized sensitivity functions in physiological system identification. Ann.

Biomed. Eng. 27: 607-616, 1999.

170. Toffolo G., Cefalu W., Cobelli C.: Beta cell function during insulin modified IVGTT successfully assessed by

the C-peptide minimal model. Metabolism 48: 1162-1166, 1999.

171. Vicini P., Caumo A., Cobelli C.: Glucose effectiveness and insulin sensitivity from the minimal models:

consequences of undermodeling assessed by Monte Carlo simulation. IEEE Trans. Biomed. Eng. 46: 130-137,

1999.

172. Vicini P. Cobelli C.: A priori identifiability of distributed models of blood-tissue exchange. Ann. Biomed. Eng.

27: 200-207, 1999.

173. Vicini P., Zachwieja J.J., Yarasheski K.E., Bier D.M., Caumo A., Cobelli C.: Glucose production during an

IVGTT by deconvolution: validation with the tracer-to-tracee clamp technique. Am. J. Physiol. 276: E285-294,

1999.

174. Konrad T., Vicini P., Zeuzem S., Toffolo G., Briem D., Lormann J., Herrmann G., Wittmann D., Lenz T.,

Kusterer K., Teuber G., Cobelli C., Usadel K.H.: Interferon-alpha improves glucose tolerance in diabetic and

non-diabetic patients with HCV-induced liver disease. Exp Clin Endocrinol Diabetes. 107:343-9, 1999.

175. Nucci G., Cobelli C.: Models of subcutaneous insulin kinetics. A critical review. Comp. Meth. Progr. Biomed.

62: 249-257, 2000.

176. Hoffman R.P., Vicini P., Sivitz W.I., Cobelli C.: Pubertal adolescent male-female differences in insulin

sensitivity and glucose effectiveness determined by the one compartment minimal model. Pediatric Research

48:384-388, 2000.

177. Utriainen T., Lovisatti S., Mäkimattila S., Bertoldo A., Weintraub S., DeFronzo R., Cobelli C., Yki-Järvinen:

Direct measurement of the lumped constant for 2-deoxy-[1-14C]glucose in vivo in human skeletal muscle. Am.

J. Physiol. 279: E228-233, 2000.

178. Sparacino G., Tombolato C., Cobelli C.: Maximum-likelihood versus maximum a posteriori parameter

estimation of physiological system models: the C-peptide impulse response case study. IEEE Trans. Biomed.

Eng. 47: 801-811, 2000.

179. Sparacino G., Bardi F., Cobelli C.: Approximate entropy studies of hormone pulsatility from plasma

concentration time series: influence of the kinetics assessed by simulation. Ann. Biomed. Eng. 28: 665-676,

2000.

180. Kalliokoski K.K., Kemppainen J., Larmola K., Takala T.O., Peltoniemi P., Oksanen A., Ruotsalainen U.,

Knuuti M.J., Cobelli C., Nuutila P.: Muscle perfusion and perfusion heterogeneity during exercise studied with

positron emission tomography in humans. Eur. J. A Physiol. 83:395-401, 2000.

181. Konrad T., Steinmuller T., Vicini P., Toffolo G., Grewerus D., Schuller A., Bechstein W.O., Usadel K.H.,

Cobelli C., Mahon A., Wittmann W., Klar E., Golling M., Neuhaus P.: Evidence for impaired glucose

effectiveness in cirrhotic patients after liver transplantation. Metabolism 49: 367-72, 2000.

182. Konrad T., Steinmuller T., Vicini P., Toffolo G., Grewerus D., Schuller A., Bechstein W.O., Usadel K.H.,

Cobelli C., Neuhaus P.: Regulation of glucose tolerance in patients after liver transplantation: impact of

cyclosporin versus tacrolimus therapy. Transplantation 27: 2072-8, 2000.

183. Konrad T., Zeuzem S., Toffolo G., Vicini P., Teuber G., Briem D., Lormann J., Lenz T., Herrmann G., Berger

A., Cobelli C., Usadel K.H.: Severity of HCV-induced liver damage alters glucose homeostasis in noncirrhotic

patients with chronic HCV infection. Digestion 62: 52-59, 2000

.

184. Konrad T., Zeuzem S., Vicini P., Toffolo G., Briem D., Lormann J., Herrmann G., Berger A., Kusterer K.,

Teuber G., Cobelli C., Usadel K.H.: Evaluation of factors controlling glucose tolerance in patients with HCV

infection before and after 4 months therapy with interferon-a. Eur. J. Clin. Invest. 30: 111-121, 2000.

185. Magni P., Bellazzi R., Sparacino G., Cobelli C.: Bayesian identification of a population compartmental model

of C-peptide kinetics. Ann. Biomed. Eng. 28: 812-823, 2000.

186. Nucci G., Mergoni M., Bricchi C., Polese G., Cobelli C., Rossi A. : On line monitoring of intrinsic PEEP in

ventilator-dependent patients. J Appl. Physiol. 89:985-995, 2000.

187. Nielsen M.F., Nyholm B., Caumo A., Chandramouli V., Schumann W.C., Cobelli C., Landau, B.R., Rizza

R.A., Schmitz O.: Prandial glucose effectiveness and fasting gluconeogenesis in insulin resistant first-degree

relatives of patients with type 2 diabetes. Diabetes 49:2135-2141.2000.

188. Caumo A., Bergman RN., Cobelli C.: Insulin sensitivity from meal tolerance tests in normal subjects: a minimal

model index. J. Clin. End. Metab. 85:4396-4402, 2000

189. Vicini P., Cobelli C.: The iterative two-stage population approach to IVGTT minimal modeling: improved

precision with reduced sampling. Intravenus glucose tolerance test. Am. J. Physiol. 280: E179-186, 2001.

190. Audoly S., Bellu G., D'Angio L., Saccomani M.P., Cobelli C.: Global identifiability of nonlinear models of

biological systems. IEEE Trans. Biomed. Eng. 48: 55-65, 2001.

191. Bellazzi R., Nucci G., Cobelli C.: The subcutaneous route to insulin-dependent diabetes therapy: closed-loop

and partially closed-loop control strategies for insulin delivery and measuring glucose concentration. IEEE.

Eng. Med. Biol. 20: 54-64, 2001.

192. Bertoldo A., Peltoniemi P., Oikonen V., Knuuti J., Nuutila P., Cobelli C.: Kinetic modeling of [18F]FDG in

skeletal muscle by PET: a four compartment five rate constant model. Am. J. Physiol. 281: E524-536, 2001.

193. Breda E., Cavaghan M.K., Toffolo G., Polonsky K.S., Cobelli C.: Oral Glucose tolerance test minimal model

indexes of Beta-cell function and insulin sensitivity in a single individual. Diabetes 50: 150-158, 2001.

194. Breda E., Cobelli C.: Insulin secretion rate during glucose stimuli: alternative analyses of C-peptide data. Ann.

Biomed. Eng. 29: 692-700, 2001.

195. Kelley D.E., Price J.C., Cobelli C.: Assessing skeletal muscle glucose metabolism with positron emission

tomography. IUBMB Life 52: 279-284, 2001.

196. Konrad T., Golling M., Vicini P., Toffolo G., Wittman M., Mahon A., Klar E., Cobelli C., Usadel K.: Insulin

sensitivity and Beta-cell secretion after liver transplantation in patients with acute liver failure. Transplant. Proc.

33: 2576-2579, 2001.

197. Konrad T., Markus B., Allers C., Vicini P., Toffolo G., Lakos C., Viehmann K., Hanisch E., Encke A., Cobelli

C., Usadel K.H.: Impact of cyclosporine and low-dose steroid therapy on insulin sensitivity and Beta-cell

function in patients with long-term liver grafts. Transpl. Int. 14: 6-11, 2001.

198. Pillonetto G., Sparacino G., Cobelli C.: Reconstructing insulin secretion rate after a glucose stimulus by an

improved stochastic deconvolution method. IEEE Trans. Biomed. Eng. 48: 1352-1354, 2001.

199. Sunehag A.L., Treuth M.S., Toffolo G., Butte N.F., Cobelli C., Bier D.M., Haymond M.W.: Glucose

production, gluconeogenesis, and insulin sensitivity in children and adolescents: an evaluation of their

reproducibility. Pediatr. Res. 50: 115-23, 2001.

200. Toffolo G., Breda E., Cavaghan M.K., Ehrmann D.A., Polonsky K.S., Cobelli C.: Quantitative indexes of Beta-

cell function during graded Up&Down glucose infusion from C-peptide minimal models. Am. J. Physiol. 280:

E2-10, 2001.

201. Breda E., Toffolo G., Polonsky K.S, Cobelli C.: Insulin release in impaired glucose tolerance. Oral minimal

model predicts normal sensitivity to glucose but detective response times. Diabetes 51: S227-233, 2002.

202. Sunehag A.L., Toffolo G., Treuth M.S., Butte N.F., Cobelli C., Bier D.M., Haymond M.W.: Effects of dietary

macronutrient content on glucose metabolism in children. J. Clin. End. Metab. 87:5168-5178, 2002.

203. Bellazzi R., Larizza C., Montani S., Riva A., Stefanelli M., d’Anunzio G., Lorini R., Gomez E.J., Hernando E.,

Brugues E., Cermeno J., Corcoy R., de Leiva A., Cobelli C., Nucci G., Del Prato S., Maran A., Kilkki E.,

Tuominen J.: A telemedicine support for diabetes management: the EU T-IDDM. Comput. Methods Progr.

Biomed. 69: 147-161, 2002.

204. Callegari T., Caumo A., Cobelli C.: Generalization of MAP estimation in SAAM II: validation against ADAPT

II in a glucose model case study. Ann. Biomed. Eng. 30: 961-968, 2002.

205. Ehrmann D.A., Breda E., Cavaghan M.K., Bajramovic S., Imperial J., Toffolo G., Cobelli C., Polonsky K.S.:

Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired

glucose tolerance. Diabetologia 45: 509-517, 2002.

206. Dalla Man C., Caumo A., Cobelli C.: The oral glucose minimal model: estimation of insulin sensitivity from a

meal test. IEEE Trans. Biomed. Eng. 49: 419-429, 2002.

207. Hoffman R.P., Vicini P., Cobelli C.: Comparison of insulin sensitivity and glucose effectiveness determined by

the one- and two-compartment-labeled minimal model in late prepubertal children and early adolescents.

Metabolism 51: 1582-1586, 2002.

208. Nucci G., Tessarin S., Cobelli C.: A morphometric model of lung mechanics for time-domain analysis of

alveolar pressures during mechanical ventilation. Ann. Biomed. Eng. 30: 537–545, 2002.

209. Pillonetto G., Sparacino G., Cobelli C.: Handling non-negativity in deconvolution of physiological signals: a

nonlinear stochastic approach. Ann. Biomed. Eng. 30: 1077-1087, 2002.

210. Pillonetto G., Sparacino G., Magni P., Bellazzi R., Cobelli C.: Minimal model SI=0 problem in NIDDM

subjects: nonzero Bayesian estimates with credible confidence intervals. Am. J. Physiol. 282: E564-573, 2002.

211. Singhal P., Caumo A., Carey P.E., Cobelli C., Taylor R.: Regulation of endogenous glucose production after a

mixed meal in type 2 diabetes. Am. J. Physiol. 83: E275-283, 2002.

212. Sparacino G., Milani S., Arslan E., Cobelli C.: A Bayesian approach to estimate evoked potentials. Comput.

Meth. Progr. Biomed. 68: 233-248, 2002.

213. Sparacino G., Pillonetto G., Capello M., De Nicolao G., Cobelli C.: WINSTODEC: a stochastic deconvolution

interactive program for physiological and pharmacokinetic systems. Comput. Meth. Progr. Biomed 67: 67-77,

2002.

214. Sparacino G., Shames D.M., Vicini P., King J.C., Cobelli C.: Double isotope tracer method for measuring

fractional zinc absorption: theoretical analysis. Am. J. Physiol. 282: E679-687, 2002.

215. Vicini P., Avogaro A., Spilker M.E., Gallo A., Cobelli C.: Epinephrine effects on insulin-glucose dynamics: the

labeled IVGTT two-compartment minimal model approach. Am. J. Physiol. 283: E78-84, 2002.

216. Bellazzi R., Larizza C., Montani S., Riva A., Stefanelli M., D'Annunzio G., Lorini R., Gomez E.J., Hernando E.,

Brugues E., Cermeno J., Corcoy R., De Leiva A., Cobelli C., Nucci G., Del Prato S., Maran A., Kilkki E.,

Tuominen J.: A telemedicine support for diabetes management: the T-IDDM project. Comput Methods

Programs Biomed. 69(2):147-61, 2002.

217. Williams K.V., Bertoldo A., Kinahan P., Cobelli C., Kelley D.E.: Weight loss-induced plasticity of glucose

transport and phosphorylation in the insulin resistance of obesity and type 2 diabetes. Diabetes: 52:1619-26,

2003.

215. Williams K.V., Bertoldo A., Mattioni B., Price J.C., Cobelli C., Kelley D.E.: Glucose transport and

phosphorylation in skeletal muscle in obesity: insight from a muscle-specific positron emission tomography

model. J. Clin. Endocrinol. Metab. 88:1271-9, 2003.

216. Basu R., Di Camillo B., Toffolo G., Basu A., Shah P., Vella A., Rizza R., Cobelli C.: Use of a novel triple-

tracer approach to assess postprandial glucose metabolism. Am. J. Physiol. 284: E55-69, 2003.

217. Toffolo G., Cobelli C.: The hot IVGTT two-compartment minimal model: an improved version. Am. J.

Physiol. 284: E317-321, 2003.

218. Avogaro A., Toffolo G., Kiwanuka E., DeKreutzenberg S., Tessari P., Cobelli C.: L-arginine-nitric oxide

kinetics in normal and type 2 diabetic subjects: a stable-labelled 15n arginine approach. Diabetes 52:795-802,

2003.

219. Basu R., Breda E., Oberg A.L., Powell C.C., Dalla Man C., Basu A., Vittone J.L., Klee G.G., Arora P., Jensen

M.D., Toffolo G., Cobelli C., Rizza R.A.: Mechanisms of the age-associated deterioration in glucose tolerance:

contribution of alterations in insulin secretion, action, and clearance. Diabetes 52:1738-1748, 2003.

220. Pillonetto G., Sparacino G., Cobelli C.: Numerical non-identifiability regions of the minimal model of glucose

kinetics: superiority of Bayesian estimation. Math. Biosci. 184:53-67, 2003.

221. Toffolo G., Albright R., Joyner M., Dietz N., Cobelli C., Nair KS.: Model to assess muscle protein turnover:

domain of validity using amino acyl-tRNA vs. surrogate measures of precursor pool. Am J Physiol Endocrinol

Metab. 285(5): E1142-9, 2003.

222. Callegari T., Caumo A., Cobelli C.: Bayesian two-compartment and classic single-compartment minimal

models: comparison on insulin modified IVGTT and effect of experiment reduction. IEEE Trans Biomed Eng.

50(12):1301-9, 2003.

223. Basu R., Singh R.J., Basu A., Chittilapilly E.G., Johnson C.M., Toffolo G., Cobelli C., Rizza R.A.: Splanchnic

cortisol production occurs in humans: evidence for conversion of cortisol to cortisone via the 11- hydroxy

steroid dehydrogenase 11- HSD type 1 pathway. Diabetes 53:2051-2059, 2004.

224. Magni P., Sparacino G., Bellazzi R., Toffolo G., Cobelli C.: Insulin minimal model indexes and secretion:

proper handling of uncertainty by a Bayesian approach. Ann. Biomed. Eng. 32:1027-1037, 2004.

225. Bertoldo A., Sparacino G., Cobelli C.: Population approaches improve parameter estimation of kinetic models

from dynamic PET data. IEEE Trans. Med. Imaging 23:297-306, 2004.

226. Dalla Man C., Caumo A., Basu R., Rizza R., Toffolo G., Cobelli C.: Minimal model estimation of glucose

absorption and insulin sensitivity from oral test: validation with a tracer method. Am. J. Physiol. 287:E637-343,

2004.

227. Ehrmann D.A., Breda E., Corcoran M.C., Cavaghan M.K., Imperial J., Toffolo G., Cobelli C., Polonsky K.S.:

Impaired Beta-cell compensation to dexamethasone-induced hyperglycemia in women with polycystic ovary

syndrome. Am. J. Physiol. Endocrinol. Metab. 287:E241-6, 2004.

228. Krssak M., Brehm A., Bernroider E., Anderwald C., Nowotny P., Dalla Man C., Cobelli C., Cline G.W.,

Shulman G.I., Waldhäusl W., Roden M.: Alteration in postprandial hepatic glycogen metabolism in type 2

diabetes. Diabetes 53:3048-56, 2004.

229. Nielsen M.F., Caumo A., Chandramouli V., Schumann W.C., Cobelli C., Landau B.R., Vilstrup H., Rizza R.A.,

Schmitz O.: Impaired basal glucose effectiveness but unaltered fasting glucose release and gluconeogenesis

during short-term hypercortisolemia in healthy subjects. Am. J. Physiol. Endocrinol Metab. 286:E102-110,

2004.

230. Bertoldo A., Price J., Mathis C., Mason S., Holt D., Kelley C., Cobelli C., Kelley D.E.: Quantitative assessment

of glucose transport in human skeletal muscle: dynamic positron emission tomography imaging of [O-methyl-

11C]3-O-methyl-D-glucose. J. Clin. Endocrinol. Metab. 90:1752-9, 2005.

231. Carey P.E., Gerrard J., Cline G.W., Dalla Man C.: English PT, Firbank MJ, Cobelli C, Taylor R. Acute

inhibition of lipolysis does not affect postprandial suppression of endogenous glucose production. Am. J.

Physiol. Endocrinol. Metab. 289:E941-947, 2005.

232. Dalla Man C., Campioni M., Polonsky K.S., Basu R., Rizza R.A., Toffolo G., Cobelli C.: Two-hour seven-

sample oral glucose tolerance test and meal protocol: minimal model assessment of -cell responsivity and

insulin sensitivity in nondiabetic individuals. Diabetes 54:3265-3273, 2005.

233. Dalla Man C., Caumo A., Basu R., Rizza R., Toffolo G., Cobelli C.: Measurement of selective effect of insulin

on glucose disposal from labeled glucose oral test minimal model. Am. J. Physiol. Endocrinol. Metab.

289:E909-914, 2005.

234. Dalla Man C., Yarasheski K.E., Caumo A., Robertson H., Toffolo G., Polonsky K.S., Cobelli C.: Insulin

sensitivity by oral glucose minimal models: validation against clamp. Am. J. Physiol. Endocrinol. Metab.

289:E954-959, 2005.

235. Di Camillo B., Sanchez-Cabo F., Toffolo G., Nair S.K., Trajanoski Z., Cobelli C.: A quantization method based

on threshold optimization for microarray short time series. BMC Bioinformatics, 6 Suppl 4: S11, 2005

236. Lubow J.M., Pinon I.G., Avogaro A.., Cobelli C., Treeson D.M., Mandeville K.A., Toffolo G., Boyle P.J.: Brain

oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not

sufficient to offset energy deficit. Am. J. Physiol. Endocrinol. Metab. 290:E149-153, 2005.

237. Corazza S., Cobelli C.: An innovative ski-boot: design, numerical simulation and testing. J. Sports Science and

Medicine 4:229-238, 2005.

238. Basu R., Singh R.J., Basu A., Chittilapilly E.G., Johnson M.C., Toffolo G., Cobelli C., Rizza R.A.: Obesity and

type 2 diabetes do not alter splanchnic cortisol production in humans. J Clin Endocrinol Metab. 90(7):3919-26,

2005.

239. Yu J.S., Ongarello S., Fiedler R., Chen X.W., Toffolo G., Cobelli C., Trajanoski Z.: Ovarian cancer

identification based on dimensionality reduction for high-throughput mass spectrometry data. Bioinformatics.

21(10):2200-9, 2005.

240. Corazza S., Mundermann L., Chaudhari A.M., Demattio T., Cobelli C., Andriacchi T.P.: A markerless motion

capture system to study musculoskeletal biomechanics: visual hull and simulated annealing approach. Ann.

Biomed. Eng. 34:1019-29, 2006.

241. Basu R., Dalla Man C., Campioni M., Basu A., Klee G., Jenkins G., Toffolo G., Cobelli C., Rizza R.A.: Effect

of age and sex on postprandial glucose metabolism: difference in glucose turnover, insulin secretion, insulin

action, and hepatic insulin extraction. Diabetes 55: 2001-14, 2006.

239. Bertoldo A., Pencek R.R., Azuma K., Price J.C., Kelley C., Cobelli C., Kelley D.E. Interactions between delivery,

transport, and phosphorylation of glucose in governing uptake into human skeletal muscle. Diabetes 55:3028-37,

2006.

240. Bock G., Dalla Man C., Campioni M., Chittilapilly E., Basu R., Toffolo G., Cobelli C., Rizza R.A.: Pathogenesis

of prediabetes: mechanisms of fasting and postprandial hyperglycemia in people with impaired fasting glucose

and/or impaired glucose tolerance. Diabetes 55:3536-49, 2006.

241. Cohw L.S., Albright R.C., Bigelow M.L., Toffolo G., Cobelli C., Nair KS: Mechanism of insulin's anabolic effect

on muscle: measurementes of muscle protein synthesis and breakdown using aminoacyl-tRNA and other

surrogate measures. Am. J. Physiol. Endocrinol. Metab. 291:E729-36, 2006.

242. Cogo P.E., Toffolo G., Ori C., Vianello A., Chierici M., Gucciardi A., Cobelli C., Baritussio A., Carnielli V.P.:

Surfactant disaturated phosphatidylcholine kinetics in human adults with acute respiratory distress syndrome

using stable isotopes. Biology of the Neonate 89:344-344, 2006.

243. Cohen O., Basu R., Bock G., Dalla Man C., Campioni M., Basu A., Toffolo G., Cobelli C., Rizza R.A.: Prediction

of postprandial glycemic exposure: utility of fasting and two hour glucose measurements alone and in

combination with assessment of body composition, fitness and strength. Diabetes Care 29:2708-13, 2006.

244. Dalla Man C., Camilleri M., Cobelli C.: A system model of oral glucose absorption: validation on gold standard

data. IEEE Trans. Biomed. Eng. 53:2472-8, 2006.

245. Lubow J.M., Pinon I.G., Avogaro A., Cobelli C., Treeson D.M., Mandeville K.A., Toffolo G., Boyle P.J.: Brain

oxygen utilization is unchanged by hypoglycemia in normal humans: lactate, alanine, and leucine uptake are not

sufficient to offset energy deficit. Am. J. Physiol. Endocrinol. Metab. 290: E149-153, 2006.

246. Magni P., Sparacino G., Bellazzi R., Cobelli C.: Reduced sampling schedule for the glucose minimal model:

importance of Bayesian estimation. Am. J. Physiol. Endocrinol. Metab. 290:E177-184, 2006.

247. Nair K.S., Rizza R.A, O’Brein P., Short K.R., Nehra A, Vittone J.L., Klee G.G, Basu A., Basu R., Cobelli C.,

Toffolo G., Dalla Man C., Tindall D.J., Melton L.J., Smith G.E., Khosla S., Jensen M.D.: Effect of two years

dehydropiandosterone in elderly men and women and testosterone in elderly men on physiological performance,

body composition and bone density. New England Journal of Medicine 355:1647-1659, 2006.

248. Pencek R.R., Bertoldo A., Price J., Kelley C., Cobelli C., Kelley D.E.: Dose-responsive insulin regulation of

glucose transport in human skeletal muscle. Am. J. Physiol. Endocrinol. Metab. 290:E1124-30, 2006.

249. Petersen K.F., Dufour S., Feng J., Befroy D., Dzuira J., Dalla Man C., Cobelli C., Shulman G.: Increased

prevalence of insulin resistance and non-alcholic fatty liver disease in asian indian men. PNAS 103:18273-7,

2006.

250. Pillonetto G., Caumo A., Sparacino G., Cobelli C.: A new dynamic index of insulin sensitivity. IEEE Trans.

Biomed. Eng. 53:369-79, 2006.

251. Sparacino G., Zanderigo F., Maran A., Cobelli C.: Continuous glucose monitoring and hypo/hyperglycaemia

prediction. Diabetes Research and Clinical Practice 74:S160–S163, 2006.

252. Toffolo G., Basu R., Dalla Man C., Rizza R.A, Cobelli C.: Assessment of postprandial glucose metabolism:

conventional dual versus triple tracer method. Am. J. Physiol. Endocrinol. Metab. 291:E800 -806, 2006.

253. Toffolo G., Campioni M., Basu R., Rizza R.A., Cobelli C.: A minimal model of insulin secretion and kinetics to

assess hepatic insulin extraction. Am. J. Physiol. Endocrinol. Metab. 290:E169 -176, 2006.

254. Denti P., Bertoldo A., Vicini P., Cobelli C.: Identification of IVGTT minimal glucose model by nonlinear mixed-

effects approaches. Conf Proc IEEE Eng Med Biol Soc. 1:5049-52, 2006.

255. Nair K.S., Rizza R.A., O'Brien P., Dhatariya K., Short K.R., Nehra A., Vittone J.L., Klee G.G., Basu A., Basu R.,

Cobelli C., Toffolo G., Dalla Man C., Tindall D.J., Melton L.J 3rd, Smith G.E., Khosla S., Jensen MD.: DHEA

in elderly women and DHEA or testosterone in elderly men. N Engl J Med. 355(16):1647-59, 2006.

256. Brazg R., Xu L., Dalla Man C., Cobelli C., Thomas K., Stein P.P.: Effect of adding sitagliptin, a dipeptidyl

peptidase-4 inhibitor, to metformin on 24-h glycaemic control and -cell function in patients with type 2

diabetes. Diabetes, Obesity and Metabolism 9:186-193, 2007.

257. Campioni M., Toffolo G., Shuster L.T., Service F.J., Rizza R.A., Cobelli C.: Incretin effect potentiates Beta-cell

responsivity to glucose as well as to its rate of change: OGTT and matched intravenous study. Am. J. Physiol.

Endocrinol. Metab. 292:E54-60, 2007.

258. Cogo P.E., Simonato M., Toffolo G., Stefanutti G., Chierici M., Cobelli C., Carnielli V.: Dexametasone therapy in

preterm infants with developing bronchopulmonary displasia: effect on pulmonary surfactant disaturated

phosphatidylcholine kinetics. Neonatology 91:323-329, 2007.

258. Bock G., Chittilapilly E., Basu R., Toffolo G., Cobelli C., Chandramouli V., Landau B.R., Rizza R.A.:

Contribution of hepatic and extrahepatic insulin resistance to the pathogenesis of impaired fasting glucose: role

of increased rates of gluconeogenesis. Diabetes 56:1703-1711, 2007.

259. Bock G., Dalla Man C., Campioni M., Chittilapilly E., Basu R., Toffolo G., Cobelli C., Rizza R.A.: Effects of

nonglucose nutrients on insulin secretion and action in people with pre-diabetes. Diabetes 56:1113-1119, 2007.

260. Cobelli C., Toffolo G.M., Dalla Man C., Campioni M., Denti P., Caumo A., Butler P., Rizza R.A.: Assessment

of Beta-cell function in humans, simultaneously with insulin sensitivity and hepatic extraction, from intravenous

and oral glucose tests. Am. J. Physiol. Endocrinol. Metab. 293:E1 -15, 2007.

261. Sparacino G., Zanderigo F., Corazza S., Maran A., Facchinetti A., Cobelli C.: Glucose concentration can be

predicted ahead in time from continuous glucose monitoring sensor time-series. IEEE Trans. Biomed. Eng.

54:931-937, 2007.

262. Facchinetti A., Sparacino G., Cobelli C.: Reconstruction of glucose in plasma from interstitial fluid continuous

glucose monitoring data: role of sensor calibration. J. Diabetes Sci. Technol. 1:617-623, 2007.

263. Di Camillo B., Toffolo G., Nair S.K., Greenlund L.J., Cobelli C.: Significance analysis of microarray transcript

levels in time series experiments. BMC Bioinformatics. 8(Suppl 1): S10, 2007.

264. Zanderigo F., Sparacino G., Kovatchev B., Cobelli C.: Glucose prediction algorithms from continuous

monitoring data: assessment of accuracy via continuous glucose error-grid analysis CG-EGA. J. Diabetes Sci.

Technol. 1:645-651, 2007.

265. Brazg R., Xu L., Dalla Man C., Cobelli C., Thomas K., Stein P.P.: Effect of adding sitagliptin, a dipeptidyl

peptidase-4 inhibitor, to to on-going metformin on 24-hour 24-hour glycemic control and Beta-cell function in

patients with type 2 diabetes. Diabetes Obesity and Metabolism 9:186-193, 2007.

266. Basu R., Dalla Man C., Campioni M., Basu A., Nair K S., Jensen M.D., Khosla S., Klee. G., Toffolo G., Cobelli

C., Rizza R.A.: Two years of treatment with deydroepiandrosterone does not improve insulin secretion action or

postprandial glucose turnover in elderly men or women. Diabetes 56:753-66, 2007.

267. Dalla Man C., Raimondo D.M., Rizza R.A., Cobelli C.: GIM, simulation software of meal glucose-insulin

model. J. Diabetes Sci. Technol. 1:323-330, 2007.

268. Basu R., Dalla Man C., Campioni M., Basu A., Nair K.S., Jensen M.D., Khosla S., Klee G., Toffolo G., Cobelli

C., Rizza R.A.: Effect of 2 years of testosterone replacement on insulin secretion, insulin action, glucose

effectiveness, hepatic insulin clearance, and postprandial glucose turnover in elderly men. Diabetes Care

30:1972-8, 2007.

269. Dalla Man C., Rizza R.A., Cobelli C.: Meal simulation model of the glucose-insulin system. IEEE Trans.

Biomed. Eng. 54:1740-9, 2007.

270. Magni L., Raimondo F., Bossi L., Dalla Man C., De Nicolao G., Kovatchev B.P., Cobelli C.: Model predictive

control of type 1 diabetes: an in silico trial. J. Diabetes. Sci. Technol. 1:804-12, 2007.

271. Pendergrass M., Bertoldo A., Bonadonna R.C., Nucci G., Mandarino L., Cobelli C., Defronzo R.A.: Muscle

glucose transport and phosphorylation in type 2 diabetic, obese nondiabetic, and genetically predisposed

individuals. Am. J. Physiol. Endocrinol. Metab. 292:E92 -100, 2007.

272. Cogo P.E., Toffolo G., Ori C., Vianello A., Chierici M., Gucciardi A., Cobelli C., Baritussio A., Carnielli V.P.:

Surfactant disaturated phosphatidylcholine kinetics in acute respiratory distress syndrome by stable isotopes and

a two compartment model. Respiratory Research 21:8-13, 2007.

273. Pillonetto G., Cobelli C.: Identifiability of the stochastic semi-blind deconvolution problem using a class of time-

invariant linear systems. Automatica 43:647-654, 2007. 274. Ravikumar B., Gerrard J., Dalla Man C., Firbank M.J., Lane A., English P.T., Cobelli C., Taylor R.: Pioglitazone

decreases fasting and postprandial endogenous glucose production in proportion to decrease in hepatic

triglyceride content. Diabetes 57:2288-95, 2008.

275. Perreault L., Bergman B.C., Playdon M.C., Dalla Man C., Cobelli C., Eckel R.H.: Impaired fasting glucose with

or without impaired glucose tolerance: progressive or parallel states of prediabetes? Am. J. Physiol. Endocrinol.

Metab. 295:E428-35, 2008.

276. Xu L., Dalla Man C., Charbonnel B., Meninger G., Davies M.J., Williams-Herman D., Cobelli C., Stein P.P.:

Effect of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on beta-cell function in patients with type 2 diabetes: a

model-based approach. Diabetes Obes. Metab. 10:1212-20, 2008.

277. Toffolo G., Dalla Man C., Cobelli C., Sunehag A.L.: Glucose fluxes during OGTT in adolescents assessed by a

stable isotope triple tracer method. J Pediatr. Endocrinol. Metab. 21:31-45, 2008.

278. Azuma K., Rádiková Z., Mancino J., Toledo F.G., Thomas E., Kangani C., Dalla Man C., Cobelli C., Holst J.J.,

Deacon C.F., He Y., Ligueros-Saylan M., Serra D., Foley J.E. Kelley D.E.: Measurements of islet function and

glucose metabolism with the dipeptidyl peptidase 4 inhibitor vildagliptin in patients with type 2 diabetes. J. Clin.

Endocrinol. Metab. 93:459-64, 2008.

279. Magni L., Raimondo D.M., Dalla Man C., Breton M., Patek S., De Nicolao G., Cobelli C., Kovatchev B.P.:

Evaluating the efficiency of closed-loop glucose regulation via control-variability grid analysis CVGA. J.

Diabetes Sci. Technol. 2:630-635, 2008.

280. Dalla Man C., Toffolo G., Basu R., Rizza R.A., Cobelli C.: Use of labeled oral minimal model to measure hepatic

insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 295:E1152-9, 2008.

281. Pedersen M.G., Corradin A., Toffolo G., Cobelli C.: Subcellular model of glucose-stimulated pancreatic insulin

secretion. Philosophical Transactions of the Royal Society of London Series A: Mathematical Physical and

Engineering Sciences 366:3525-3543, 2008.

282. Sparacino G., Facchinetti A., Maran A., Cobelli C.: Continuous glucose monitoring time series and

hypo/hyperglycemia prevention: requirements, methods, open problems. Current Diabetes Review 4:181-

192, 2008.

283. Sunehag A.L., Toffolo G., Campioni M., Bier D.M., Haymond M.W.: Short-term high dietary fructose intake

had no effects on insulin sensitivity and secretion or glucose and lipid metabolism in healthy, obese adolescents.

J. Pediatr. Endocrinol. Metab. 21:225-235, 2008.

284. Tomasi G., Edison P., Bertoldo A., Roncaroli F., Singh P., Gerhard A., Cobelli C., Brooks D.J., Turkheimer

F.E.: Novel reference region model reveals increased microglial and reduced vascular binding of 11C-R-

PK11195 in patients with Alzheimer's disease. J. Nuclear Med. 49:1249-1256, 2008.

285. Cogo P.E., Simonato M., Toffolo G., Stefanutti G., Chierici M., Cobelli C., Ori C., Carnielli V.P. : Dexamethasone therapy in preterm infants with developing bronchopulmonary dysplasia: Effect on pulmonary

surfactant disaturated phosphatidylcholine kinetics. Pediatr Res. 63:433-7, 2008.

286. Dalla Man C., Breton M.D., Cobelli C.: Physical activity into the meal glucose-insulin model of type 1 diabetes:

in silico studies. J Diabetes Sci. Technol. 3:56-67, 2009.

287. Saisho Y., Manesso E., Gurlo T., Huang C.J., Toffolo G., Cobelli C., Butler P.C.: Development of factors to

convert frequency to rate for beta-cell replication and apoptosis quantified by time-lapse video microscopy and

immunohistochemistry. Am. J. Physiol. Endocrinol. Metabol. 296:E89-96, 2009.

288. Sunehag A.L, Dalla Man C., Toffolo G., Haymond M.W., Bier D.M., Cobelli C.: Beta-cell function and insulin

sensitivity in adolescents from an OGTT. Obesity 17:233-239, 2009.

289. Tomasi G., Bertoldo A., Cobelli C.: PET parametric imaging improved by global-two-stage method. Ann.

Biomed. Eng. 37:419-427, 2009.

290. Kovatchev B.P., Breton M.D., Dalla Man C., Cobelli C.: In silico preclinical trials: a proof of concept in closed-

loop control of type 1 diabetes. J. Diabetes. Sci. Technol. 3:44-55, 2009.

291. Dalla Man C., Bock G., Giesler P.D., Serra D.B., Ligueros Saylan M., Foley J.E., Camilleri M., Toffolo G.,

Cobelli C., Rizza R.A, Vella A.: Dipeptidyl peptidase 4 inhibition by vildagliptin and the effect on insulin

secretion and action in response to meal ingestion in type 2 diabetes. Diabetes Care 32:14-8, 2009.

292. Cali A.M., Dalla Man C., Cobelli C., Dziura J., Seyal A., Shaw M., Allen K., Chen S., Caprio S.: Primary

defects in -cell function further exacerbated by worsening of insulin resistance mark the development of

impaired glucose tolerance in obese adolescents. Diabetes Care 32:456-61, 2009.

293. Basu A., Dalla Man C., Basu R., Toffolo G., Cobelli C., Rizza R.A.: Effects of Type 2 diabetes on insulin

secretion, insulin action, glucose effectiveness and postprandial glucose metabolism. Diabetes Care 32:866-72,

2009.

294. Bruttomesso D., Farret A., Costa S., Marescotti M.C., Vettore M., Avogaro A., Tiengo A., Dalla Man C., Place

J., Facchinetti A., Guerra S., Magni M., De Nicolao G., Cobelli C., Renard E., Maran A.: Closed-loop artificial

pancreas using subcutaneous glucose sensing and insulin delivery and a model predictive control algorithm:

preliminary studies in Padova and Montpellier. J. Diabetes Sci. Technol. 3:1014-1021, 2009.

295. Magni L., Forgione M., Toffanin C., Dalla Man C., Kovatchev B.P., De Nicolao G., Cobelli C.: Run-to-run

tuning of model predictive control for type 1 diabetes subjects: in silico trial. J. Diabetes Sci. Technol. 3:1091-

1098, 2009.

296. Cobelli C., Dalla Man C., Sparacino G., Magni L., De Nicolao G., Kovatchev B.P.: Diabetes: models, signals,

and control. IEEE Rev. Biomed. Eng. 2:54-96, 2009.

297. Campioni M., Toffolo G.M., Basu R., Rizza R.A., Cobelli C.: Minimal model assessment of hepatic insulin

extraction during an oral test from standard insulin kinetic parameters. Am. J. Physiol. Endocrinol. Metab. 298:

E941-8, 2009.

298. Denti P., Bertoldo A., Vicini P., Cobelli, C.: Nonlinear mixed effects to improve glucose minimal model

parameter estimation: a simulation study in intensive and sparse sampling. IEEE Trans. Biomed. Eng. BME

56:2156-66, 2009.

299. Di Camillo B., Toffolo G., Cobelli C.: A gene network simulator to assess reverse engineering algorithms.

Annals of the New York Academy of Sciences 2009.

300. Donà G., Preatoni E., Cobelli C., Rodano R., Harrison A.J.: Application of functional principal component

analysis in race walking: an emerging methodology. Sports Biomechanics 8:284–301, 2009.

301. Manesso E., Toffolo G.M., Saisho Y., Butler A.E., Matveyenko A.V., Cobelli C., Butler P.C.: Dynamics of

beta-cell turnover; evidence for beta-cell turnover and regeneration from sources of beta-cells other than beta-

cell replication in the HIP rat. Am. J. Physiol. Endocrinol. Metab. 297:E323-30, 2009.

302. Pillonetto G., De Nicolao G., Chierici M., Cobelli C.: Fast algorithms for nonparametric population modeling of

large data sets. Automatica 45:173-179, 2009.

303. Sawacha Z., Cristoferi G., Guarneri G., Corazza S., Donà G., Denti P., Facchinetti A., Avogaro A., Cobelli C.:

Characterizing multisegment foot kinematics during gait in diabetic foot patients. J. Neuroeng. Rehabil. 6:37,

2009.

304. Sawacha Z., Guarneri G., Cristoferi G., Guiotto A., Avogaro A., Cobelli C.: Diabetic gait and posture

abnormalities: A biomechanical investigation through three dimensional gait analysis. Clinical Biomechanics

24:722-728, 2009.

305. Zanderigo F., Bertoldo A., Pillonetto G., Cobelli C.: Nonlinear stochastic regularization to characterize tissue

residue function in bolus-tracking MRI: assessment and comparison with SVD, block-circulant SVD and

Tikhonov. IEEE Trans. Biomed. Eng. 56:1287-1297, 2009.

306. Dalla Man C., Toffolo G., Basu R., Rizza R.A., Cobelli C.: Use of labeled oral minimal model to measure

hepatic insulin sensitivity. Am. J. of Physiol. Endocrinol. Metab. 295:1152-1159, 2009.

307. Klonoff D.C., Cobelli C., Kovatchev B., Zisser H.C.: Progress in development of an artificial pancreas. Journal

of Diabetes Science and Technology 3:1002-1004; 2009.

308. Kovatchev B., Patek S., Dassau E., Doyle F.J. 3rd, Magni L., De Nicolao G., Cobelli C.: Juvenile diabetes

research foundation artificial pancreas consortium: control to range for diabetes: functionality and modular

architecture. Journal of Diabetes Science and Technology 3:1058-1065, 2009.

309. Chandler-Laney P.C., Phadke R.P., Granger W.M., Fernández J.R., Muñoz J.A., Man C.D., Cobelli C., Ovalle

F., Gower B.A.: Age-related changes in insulin sensitivity and β-cell function among european-american and

african-american women. Obesity 19:528-35, 2010.

310. Balasubramanian R., Gerrard J., Dalla Man C., Firbank M.J., Lane A., English P.T., Cobelli C., Taylor R.:

Combination peroxisome proliferator-activated receptor gamma and alpha agonist treatment in Type 2 diabetes

prevents the beneficial pioglitazone effect on liver fat content. Diabetic Medicine 27:150-156, 2010.

311. Butler A.E., Cao-Minh L., Galasso R., Rizza R.A., Corradin A., Cobelli C., Butler P.C.: Adaptive changes in

pancreatic beta cell fractional area and beta cell turnover in human pregnancy. Diabetologia 53:2167-2176, 2010.

312. Chandler-Laney P.C., Phadke R.P., Granger W.M., Muñoz J.A., Dalla Man C., Cobelli C., Ovalle F., Fernández

J.R., Gower B.A.: Adiposity and β-cell function: relationships differ with ethnicity and age. Obesity 18:2086-

2092, 2010.

313. Dalla Man C., Micheletto F., Sathananthan A., Rizza R.A., Vella A., Cobelli C.: A model of GLP-1 action on

insulin secretion in nondiabetic subjects. Am. J. of Physiol. Endocrinol. Metab. 298:E1115-E1121, 2010.

314. De Kreutzenberg S.V., Ceolotto G., Papparella I., Bortoluzzi A., Semplicini A., Dalla Man C., Cobelli C., Fadini

G.P., Avogaro A.: Downregulation of the longevity-associated protein sirtuin 1 in insulin resistance and

metabolic syndrome: potential biochemical mechanisms. Diabetes 59:1006-1015, 2010.

315. Denti P., Bertoldo A., Vicini P., Cobelli C.: IVGTT glucose minimal model covariate selection by nonlinear

mixed-effects approach. Am. J. Physiol. Endocrinol. Metab. 298:E950-E960, 2010.

316. Facchinetti A., Sparacino G., Cobelli C.: An on-line self-tuneable method to denoise CGM sensor data. IEEE

Trans. Biomed. Eng. 57:634-641, 2010.

317. Facchinetti A., Sparacino G., Cobelli C.: Enhanced accuracy of continuous glucose monitoring by online

extended Kalman filtering. Diabetes Technology and Therapeutics 12:353-363, 2010.

318. Facchinetti A., Sparacino G., Cobelli C.: Modeling the error of continuous glucose monitoring sensor data:

critical aspects discussed through simulation studies. Journal of Diabetes Science and Technology 4:4-14, 2010.

319. Kovatchev B., Cobelli C., Renard E., Anderson S., Breton M., Patek S., Clarke W., Bruttomesso D., Maran A.,

Costa S., Avogaro A., Dalla Man C., Facchinetti A., Magni L., De Nicolao G., Place J., Farret A.: Multinational

study of subcutaneous model-predictive closed-loop control in type 1 diabetes mellitus: summary of the results.

Journal of Diabetes Science and Technology 4:1374-1381, 2010.

320. Perreault L., Man C.D., Hunerdosse D.M., Cobelli C., Bergman B.C.: Incretin action maintains insulin secretion,

but not hepatic insulin action, in people with impaired fasting glucose. Diabetes Research and Clinical Practice

90:87-94, 2010.

321. Pillonetto G., Caumo A., Cobelli C.: Dynamic insulin sensitivity index: importance in diabetes. Am. J. Physiol.

Endocrinol. Metab. 298:E440-E448, 2010.

322. Pérez-Gandía C., Facchinetti A., Sparacino G., Cobelli C., Gómez E.J., Rigla M., De Leiva A., Hernando M.E.:

Artificial neural network algorithm for online glucose prediction from continuous glucose monitoring. Diabetes

Technology and Therapeutics 12:81-88, 2010.

323. Saisho Y., Butler A.E., Manesso E., Galasso R., Zhang L., Gurlo T., Toffolo G.M., Cobelli C., Kavanagh K.,

Wagner J.D., Butler P.C.: Relationship between fractional pancreatic beta cell area and fasting plasma glucose

concentration in monkeys. Diabetologia 53:111-114, 2010.

324. Sathananthan A., Dalla Man C.., Micheletto F., Zinsmeister A.R., Camilleri M., Giesler P.D., Laugen J.M.,

Toffolo G.M., Rizza R.A., Cobelli C., Vella A.: Common genetic variation in GLP1R and insulin secretion in

response to exogenous GLP-1 in nondiabetic subjects: a pilot study. Diabetes Care 33:2074-2076, 2010.

325. Sawacha Z., Guarneri G., Avogaro A., Cobelli C.: A new classification of diabetic gait pattern based on cluster

analysis of biomechanical data. Journal of Diabetes Science and Technology 4:1127-1138, 2010.

326. Sparacino G., Facchinetti A., Cobelli C.: Smart continuous glucose monitoring sensors: on-Line signal

processing issues. Sensors 10:6751-6772, 2010.

327. Zanderigo F., Ogden R.T., Bertoldo A., Cobelli C., Mann J.J., Parsey R.V.: Empirical Bayesian estimation in

graphical analysis: a voxel-based approach for the determination of the volume of distribution in PET studies.

Nuclear Medicine and Biology 37:443-451, 2010.

328. Lavezzo E., Toppo S., Barzon L., Cobelli C., Di Camillo B., Finotello F., Franchin E., Peruzzo D., Toffolo G.M.,

Trevisan M., Palù G.: Draft genome sequences of two Neisseria meningitidis serogroup C clinical isolates.

Journal of Bacteriology 192:5270-5271, 2010.

329. Pedersen M.G., Toffolo G., Cobelli C.: Cellular modeling: insight into oral minimal models of insulin secretion.

Am. J. of Physiol. Endocrinol. Metab. 298:E597-E601, 2010.

330. Bock G., Dalla Man C., Micheletto F., Basu R., Giesler P.D., Laugen J., Deacon C.F., Holst J.J., Toffolo G.,

Cobelli C., Rizza R.A., Vella A.: The effect of DPP-4 inhibition with sitagliptin on incretin secretion and on

fasting and postprandial glucose turnover in subjects with impaired fasting glucose. Clinical Endocrinology 73:

189-196, 2010.

331. Manesso E., Toffolo G.M., Basu R., Rizza R.A., Cobelli C.: Modelling non-steady state metabolism from

arteriovenous data. IEEE Trans. Biomed. Eng. 58:1253-1259,2011.

332. Manesso E., Toffolo G., Butler A:E., Butler P.C., Cobelli C. :Shortened beta-cell lifespan leads to beta.cell

deficit in a riodent model of type 2 diabetes. Am. J. Physiol. Endocrinol. Metab. 300:E933-E938, 2011.

333. Ceseracciu E., Sawacha Z., Fantozzi S., Cortesi M., Gatta G., Corazza S., Cobelli C.: Markerless analysis of

front crawl swimming. Journal of Biomechanics 44:2236-42, 2011.

334. Cobelli C., Renard E., Kovatchev B.: Artificial pancreas: past, present, future. Diabetes 60:2672-82, 2011.

335. Corradin A., Di Camillo B., Ciminale V., Toffolo G., Cobelli C.: Sensitivity analysis of retrovirus HTLV-1

transactivation. J. Comput. Biol. 18:183-93, 2011.

336. Del Din S., Carraro E., Sawacha Z., Guiotto A., Bonaldo L., Masiero S., Cobelli C.: Impaired gait in ankylosing

spondylitis. Medical & Biological Engineering & Computing 49:801-809, 2011.

337. Facchinetti A., Sparacino G., Cobelli C.: Online denoising method to handle intraindividual variability of signal-

to-noise ratio in continuous glucose monitoring. IEEE Trans Biomed Eng. 58:2664-71, 2011.

338. Facchinetti A., Sparacino G., Trifoglio E., Cobelli C.: A new index to optimally design and compare continuous

glucose monitoring glucose prediction algorithms. Diabetes Technology and Therapeutics 13:111-9, 2011.

339. Fisher G., Alvarez JA., Ellis AC., Granger WM., Ovalle F., Dalla Man C., Cobelli C.: Gower BA Race

differences in the association of oxidative stress with insulin sensitivity in African- and European-American

women. Obesity 19 :1930-7381, 2011.

340. Guerra S., Sparacino G., Facchinetti A., Schiavon M., Dalla Man C., Cobelli C.: A dynamic risk measure from

continuous glucose monitoring data. Diabetes Technology and Therapeutics 13:843-52, 2011.

341. Pedersen MG., Dalla Man C., Cobelli C.: Multiscale modeling of insulin secretion. IEEE Trans. Biomed. Eng.

58:3020-3023, 2011.

342. Peruzzo D., Bertoldo A., Zanderigo F., Cobelli C.: Automatic selection of arterial input function on dynamic

contrast-enhanced MR images. Computer Methods and Programs in Biomedicine 104:e148-e157, 2011.

343. Saisho Y., Manesso E., Butler AE., Galasso R., Kavanagh K., Flynn M., Zhang L., Clark P., Gurlo T., Toffolo

GM., Cobelli C., Wagner JD., Butler PC.: Ongoing {beta}-cell turnover in adult nonhuman primates is not

adaptively increased in streptozotocin-induced diabetes. Diabetes, 60:848-56, 2011.

344. Sivananthan S., Naumova V., Dalla Man C., Facchinetti A., Renard E., Cobelli C., Pereverzyev S.V.:

Assessment of blood glucose predictors: the prediction-error grid analysis. Diabetes Technology and

Therapeutics 13:787-96, 2011.

345. Peruzzo D., Zanderigo F., Bertoldo A., Pillonetto G., Cosottini M., Cobelli C.: Assessment on clinical data of

nonlinear stochastic deconvolution versus Singular Value Decomposition for quantitative Dynamic

Susceptibility Contrast-Magnetic Resonance Imaging. Magn Reson Imaging. 29:927-36, 2011.

346. Smushkin G., Sathananthan A., Dalla Man C., Zinsmeister A.R., Camilleri M., Cobelli C., Rizza R.A., Vella A.:

Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes.

The Journal of Clinical Endocrinology and Metabolism 97:589-598, 2011.

347. Tomasi G., Bertoldo A., Cobelli C., Pavese N., Tai Y., Hammers A., Turkheimer FE.: Global-two-stage filtering

of clinical PET parametric maps: application to [(11)C]-(R)-PK11195. Neuroimage 55:942-953, 2011.

348. Vigili de Kreutzenberg S., Fadini G.P., Boscari F., Rossi E., Guerra S., Sparacino G., Cobelli C., Ceolotto G.,

Bottero M., Avogaro A.: Impaired hemodynamic response to meal intake in insulin-resistant subjects: an

impedance cardiography approach. Am J Clin Nutr. 93:926-33, 2011.

349. Tomasi G., Bertoldo A., Cobelli C., Pavese N., Tai Y., Hammers A., Turkheimer FE.: Global-two-stage filtering

of clinical PET parametric maps: Application to [(11)C]-(R)-PK11195. Neuroimage 55:942-953, 2011.

350. Chandler-Laney P.C., Phadke R.P., Granger W.M., Fernández J.R., Muñoz J.A., Dalla Man C., Cobelli C.,

Ovalle F., Gower B.A. : Age-related changes in insulin sensitivity and β-cell function among European-

American and African-American women. Obesity 19:528-35, 2011.

351. Fisher G., Alvarez JA., Ellis A.C., Granger WM., Ovalle F., Dalla Man C., Cobelli C., Gower B.A.: Race

differences in the association of oxidative stress with insulin sensitivity in African- and European-American

women. Obesity 20:972-7, 2012.

352. Smushkin G., Sathananthan M., Sathananthan A., Dalla Man C., Micheletto F., Zinsmeister A.R., Cobelli C.,

Vella A.: Diabetes-associated common genetic variation and its association with GLP-1 concentrations and

response to exogenous GLP-1. Diabetes 61:1082-9, 2012.

353. Smushkin G., Sathananthan A., Dalla Man C., Zinsmeister A.R., Camilleri M., Cobelli C., Rizza R.A., Vella A.:

Defects in GLP-1 response to an oral challenge do not play a significant role in the pathogenesis of prediabetes. J

Clin Endocrinol Metab. 97:589-98, 2012.

354. Guerra S., Facchinetti A., Sparacino G., Nicolao G.D., Cobelli C.: Enhancing the accuracy of subcutaneous

glucose sensors: a real-time deconvolution-based approach. IEEE Trans. Biomed. Eng. 59:1658-69, 2012.

355. Sawacha Z., Guarneri G., Cristoferi G., Guiotto A., Avogaro A., Cobelli C.: Integrated kinematics-kinetics-

plantar pressure data analysis: A useful tool for characterizing diabetic foot biomechanics. Gait Posture 36:20-6,

2012.

356. Di Camillo B., Sanavia T., Martini M., Jurman G., Sambo F., Barla A., Squillario M., Furlanello C., Toffolo G.,

Cobelli C.: Effect of size and heterogeneity of samples on biomarker discovery: synthetic and real data

assessment. PLoS One 7:e32200, 2012.

357. Di Camillo B., Irving B.A., Schimke J., Sanavia T., Toffolo G., Cobelli C., Nair K.S.: Function-based discovery

of significant transcriptional temporal patterns in insulin stimulated muscle cells. PLoS One 7:e32391, 2012.

358. Zecchin C., Facchinetti A., Sparacino G., De Nicolao G., Cobelli C.: Neural network incorporating meal

information improves accuracy of short-time prediction of glucose concentration. IEEE Trans Biomed Eng

59:1550-60, 2012.

359. Del Favero S., Facchinetti A., Cobelli C.: A glucose-specific metric to assess predictors and identify models.

IEEE Trans. Biomed. Eng. 59:1281-90, 2012.

360. Basu A., Pedersen M.G., Cobelli C.: Prediabetes: evaluation of β-cell function. Diabetes 61:270-1, 2012.

361. Sawacha Z., Spolaor F., Guarneri G., Contessa P., Carraro E., Venturin A., Avogaro A., Cobelli C.: Abnormal

muscle activation during gait in diabetes patients with and without neuropathy. Gait Posture 35:101-105, 2012.

362. Sathananthan A., Dalla Man C., Zinsmeister A.R., Camilleri M., Rodeheffer R.J., Toffolo G., Cobelli C., Rizza

R.A., Vella A.: A concerted decline in insulin secretion and action occurs across the spectrum of fasting and

postchallenge glucose concentrations. Clin. Endocrinol. 76:212-9, 2012.

363. Saad A., Dalla Man C., Nandy DK, Levine JA, Bharucha AE, Rizza RA, Basu R, Carter RE, Cobelli C, Kudva

YC, Basu A: Diurnal pattern to insulin secretion and insulin action in healthy individuals. Diabetes 61:2691-

2700, 2012.

364. Zanon M., Sparacino G., Facchinetti A,. Riz M., Talary M.S., Suri R.E., Caduff A., Cobelli C.: Non-invasive

continuous glucose monitoring: improved accuracy of point and trend estimates of the Multisensor system. Med

Biol Eng Comput. 50:1047-1057, 2012.

365. Breton M., Farret A., Bruttomesso D., Anderson S., Magni L., Patek S., Dalla Man C., Place J., Demartini S.,

Del Favero S., Toffanin C., Hughes-Karvetski C., Dassau E., Zisser H., Doyle F.J. 3rd, De Nicolao G., Avogaro

A., Cobelli C., Renard E., Kovatchev B. : On behalf of The International Artificial Pancreas (iAP) Study Group:

Fully integrated artificial pancreas in type 1 Diabetes: modular closed-loop glucose control maintains near

normoglycemia. Diabetes. 61:2230-2237, 2012.

366. Matveyenko A.V., Liuwantara D., Gurlo T., Kirakossian D., Dalla Man C., Cobelli C., White M.F., Copps K.D.,

Volpi E., Fujita S., Butler P.C.: Pulsatile portal vein insulin delivery enhances hepatic insulin action and

signaling. Diabetes. 61:2269-2279, 2012.

367. Denti P., Toffolo G.M., Cobelli C.: The Disposition Index: from Individual to population approach. Am. J.

Physiol. Endocrinol. Metab. 303:E576-586, 2012.

368. Di Camillo B., Falda M., Toffolo G., Cobelli C.: SimBioNeT: A simulator of biological network topology.

IEEE/ACM Trans. Comput. Biol. Bioinf. 9:592-600, 2012.

369. Guiotto A, Sawacha Z, Guarneri G, Cristoferi G, Avogaro A, Cobelli C., The role of foot morphology on foot

function in diabetic subjects with or without neuropathy. Gait Posture 37:603-610, 2012.

370. Ceccon S., Ceseracciu E., Sawacha Z., Gatta G., Cortesi M., Cobelli C., Fantozzi S.: Application of CAST

technique to 3D motion analysis of front crawl swimming. Journal of Sports Sciences 31:276-287, 2012.

371. Sawacha Z., Carraro E., Del Din S., Guiotto A., Bonaldo L., Punzi L., Cobelli C., Masiero S.: Biomechanical

assessment of balance and posture in subjects with ankylosing spondylitis. Journal of neuroengineering and

rehabilitation 29:9-63, 2012.

372. Manohar C.,. Levine J. A, Nandy D. K., Saad A., Dalla Man C., . McCrady-Spitzer S. K, Basu R., Cobelli C.,

Carter R. E., Basu A., Kudva Y. C.: The effect of walking on postprandial glycemic excursion in patients with

type 1 diabetes and healthy people. Diabetes Care 38:2493-2499, 2012.

373. Cobelli C., Renard E., Kovatchev B. P., Keith-Hynes P., Ben Brahim N., Place J., Del Favero S., Breton M.,

Farret A., Bruttomesso D., Dassau E., Zisser H., Doyle F. J., Patek S. D., Avogaro A.: Pilot studies of wearable

outpatient artificial pancreas in type 1 diabetes. Diabetes Care 35: e65-e67, 2012.

374. Sparacino G., Zanon M., Facchinetti A., Zecchin C., Maran A., Cobelli C.: Italian contributions to the

development of continuous glucose monitoring sensors for diabetes management. Sensors 12:13753-13780,

2012.

375. Soru P., De Nicolao G., Dalla Man C., Cobelli C., Magni L.: MPC based artificial pancreas: strategies for

individualization and meal compensation. Annual Reviews in Control 36:118-128, 2012.

376. Sambo F, Trifoglio E, Di Camillo B, Toffolo G, Cobelli C.: Bag of Naïve Bayes: biomarker selection and

classification from Genome-Wide SNP data. BMC Bioinformatics 13 Suppl. 14:S2, 2012.

377. Patek S., Magni L., Dassau E., Karvetski C., Toffanin C., De Nicolao G., Del Favero S., Breton M., Dalla Man

C., Renard E., Zisser H., Doyle F., Cobelli C., Kovatchev B.: Modular Closed-Loop Control of Diabetes. IEEE

Trans. Biomed. Eng. 59:2986- 2999, 2012.

378. Short K.R., Pratt L.V., Teague A.M., Dalla Man C., Cobelli C.: Postprandial improvement in insulin sensitivity

after a single exercise session in adolescents with low aerobic fitness and physical activity. Pediatric Diabetes

14:129-37, 2013.

379. Zecchin C., Facchinetti A., Sparacino G., Cobelli C.: Reduction of number and duration of hypoglycemic events

by glucose prediction methods: A proof-of-concept in silico study. Diabetes Technol Ther. 15:66-77, 2013.

380. Smushkin G., Sathananthan M., Piccinini F., Dalla Man C., Law J.H., Cobelli C., Zinsmeister A.R., Rizza R.A.,

Vella A.: The effect of a bile acid sequestrant on glucose metabolism in subjects with type 2 diabetes. Diabetes

62:1094-1101, 2013.

381. Pedersen M. G., Cobelli C.: Multiscale modelling of insulin secretion during an intravenous glucose tolerance

test. Interface Focus 3:1-5, 2013.

382. Facchinetti A., Favero S.D., Sparacino G., Cobelli C.: An online failure detection method of the glucose sensor-

insulin pump system: improved overnight safety of Type-1 diabetic subjects. IEEE Tran. Biomed. Eng. 60:406-

416, 2013.

383. Hodson K., Dalla Man C., Smith F.E., Thelwall P.E., Cobelli C., Robson S.C., Taylor R.: Mechanism of insulin

resistance in normal pregnancy. Horm. Metab. Res 45:567-571, 2013.

384. Ceccon S., Ceseracciu E, Sawacha Z., Gatta G., Cortesi M., Cobelli C., Fantozzi S.: Motion analysis of front

crawl swimming applying CAST technique by means of automatic tracking. Journal of Sports Sciences 31: 276-

287, 2013.

385. Toffanin C., Messori M., Di Palma F., De Nicolao G., Cobelli C., Magni L. Artificial pancreas: model

predictive control design from clinical experience. J Diabetes Sci Technol.7: 1470-1483, 2013.

386. Micheletto F., Dalla Man C., Kolterman O., Chiquette E., Herrmann K., Schirra J., Kovatchev B., Cobelli C.: In

silico design of optimal ratio for co-administration of pramlintide and insulin in type 1 diabetes. Diabetes

Technol Ther. 15: 802- 809, 2013.

387. Renard E., Cobelli C., Zisser H.C., Kovatchev B.P:. Artificial pancreas goes outpatient: a new diabetes

ecosystem. J Diabetes Sci Technol. 7: 1411- 1415, 2013.

388. Renard E., Cobelli C., Kovatchev B.P.: Closed loop developments to improve glucose control at home. Diabetes

Res Clin Pract 102: 79- 85, 2013.

389. Basu A., Dube S., Slama M., Errazuriz I., Amezcua J.C., Kudva Y.C., Peyser T., Carter R.E., Cobelli C., Basu

R.: Time lag of glucose from intravascular to interstitial compartment in humans. Diabetes 62: 4083- 4087,

2013.

390. Dube S., Errazuriz I., Cobelli C., Basu R., Basu A.: Assessment of insulin action on carbohydrate metabolism:

physiological and non-physiological methods. Diabetic Medicine 30:664-70, 2013.

391. Schiavon M.,Dalla Man C.,Kudva Y.C.,Basu A.,Cobelli C.: In Silico optimization of basal insulin infusion rate

during exercise: implication for artificial pancreas. J Diabetes Sci Technol. 7:1461- 1469, 2013.

392. Kovatchev B.P., Renard E., Cobelli C., Zisser H.C., Keith-Hynes P., Anderson S.M., Brown S.A.,

Chernavvsky D.R., Breton M.D., Farret A., Pelletier M.J., Place J. , Bruttomesso D., Del Favero S., Visentin

R., Filippi A., Scotton R., Avogaro A., Doyle F.J. 3rd: Feasibility of outpatient fully integrated closed-loop

control: first studies of wearable artificial pancreas. Diabetes Care 36:1851-8, 2013.

393. Junqueira Vasques A.C., Pareja J.C., De Oliveira Mda S., Satake Novaes F., Miranda de Oliveira Lima M.,

Chaim É.A., Piccinini F., Dalla Man C., Cobelli C., Geloneze B.: Beta -Cell function improvements in grade I/II

obese subjects with type 2 diabetes 1 month after biliopancreatic diversion: results from modeling analyses of

oral glucose tolerance tests and hyperglycemic clamp studies. Diabetes Care 36:4117- 4124, 2013.

394. Garcia A., Rack-Gomer A.L.,Bhavaraju N.C.,Hampapuram H.,Kamath A.,Peyser T.,Facchinetti A., Zecchin

C.,Sparacino G.,Cobelli C.: Dexcom G4AP: An advanced continuous glucose monitor for the artificial pancreas.

J Diabetes Sci Technol. 7:1436- 1445, 2013.

395. Facchinetti A., Sparacino G., Cobelli C.: Signal processing algorithms implementing the “smart sensor” concept

to improve continuous glucose monitoring in diabetes. J Diabetes Sci Technol 7:1308- 1318, 2013.

396. Facchinetti A., Del Favero S., Sparacino G. , Castle J., Ward W. , Cobelli C.: Modeling the Glucose Sensor Error

IEEE Tran. Biomed. Eng 61:620-9, 2013.

397. Zanon M., Sparacino G.,Facchinetti A., Talary M., Mueller M., Caduff A., Cobelli C.: Non-invasive continuous

glucose monitoring with multi-sensor systems: A Monte Carlo-Based methodology for assessing calibration

robustness. Sensors 13:7279- 7295, 2013.

398. Zanon M., Sparacino G., Facchinetti A., Talary M.S., Caduff A., Cobelli C.: Regularised model identification

improves accuracy of multisensor systems for noninvasive continuous glucose monitoring in diabetes

management. Journal of Applied Mathematics 2013:1- 10, 2013.

399. Zecchin C., Facchinetti A., Sparacino G., Dalla Man C., Manohar C., Levine J.A., Basu A., Kudva Y.C., Cobelli

C.: Physical activity measured by physical activity monitoring system correlates with glucose trends

reconstructed from continuous glucose monitoring. Diabetes Technol Ther 15:836- 844, 2013.

400. Sawacha Z., Carraro E., Contessa P., Guiotto A., Masiero S., Cobelli C.: Relationship between clinical and

instrumental balance assessments in chronic post-stroke hemiparesis subjects. J Neuroeng Rehabil 2013:10:95,

2013.

401. Schiavon M., Hinshaw L., Mallad A., Dalla Man C., Sparacino G., Johnson M.L., Carter R.E., Basu R., Kudva

Y.C., Cobelli C., Basu A.: Postprandial glucose fluxes and insulin sensitivity during exercise: a study in healthy

individuals. Am. J. Physiol. Endocrinol. Metab. 305:E557- E566, 2013.

402. Hinshaw L., Dalla Man C., Nandy D.K., Saad A., Bharucha A.E., Levine J.A., Rizza R.A., Basu R., Carter

R.E., Cobelli C., Kudva Y.C., Basu A.: Diurnal pattern of insulin action in type 1 diabetes: implications for a

closed loop system. Diabetes. Diabetes 62:2223-2229, 2013.

403. Sathananthan M., Farrugia L.P., Miles J.M., Piccinini F., Man C.D., Zinsmeister A.R., Cobelli C., Rizza R.A.,

Vella A.: Direct effects of exendin-(9,39) and GLP-1-(9,36)amide on insulin action, β-Cell function and glucose

metabolism in Non-Diabetic Subjects. Diabetes 62: 2752- 2756, 2013.

404. Dalla Man C., Piccinini F., Basu R., Basu A., Rizza R.A., Cobelli C.: Modeling hepatic insulin sensitivity during

a meal: validation against the euglycemic-hyperinsulinemic clamp. Am. J. Physio. Endocrinol. Metabol.

304:E819- E825, 2013.

405. Facchinetti A., Sparacino G., Guerra S., Luijf Y.M., Devries J.H., Mader J.H., Ellmerer M., Benesch C.,

Heinemann L., Bruttomesso D., Avogaro A., Cobelli C., on behalf of the Ap@home consortium: Real-time

improvement of continuous glucose-monitoring accuracy - the smart sensor concept. Diabetes Care 36:793- 800,

2013.

406. Luijf, Y.M., DeVries, J.H., Zwinderman, K., Leelarathnam, L., Nodale, M., Caldwell, K., Kumareswaran, K.,

Elleri, D., Allen, J.M., Wilinska, M.E., Evans, M.L., Hovorka, R., Doll, W., Ellmerer, M., Mader, J.K., Renard,

E., Place, J., Farret, A., Cobelli, C., Del Favero, S., Dalla Man, C., Avogaro, A., Bruttomesso, D., Filippi, A.,

Scotton, R., Magni, L., Lanzola, G., Di Palma,F., Soru, P., Toffanin, C., De Nicolao, G., Arnolds, S., Benesch,

C., Heinemann, L.; AP@home consortium: Day and night closed-loop control in adults with type 1 diabetes: a

comparison of two closed-loop algorithms driving continuous subcutaneous insulin infusion versus patient self-

management. Diabetes Care 36: 3882-3887, 2013.

407. Chandler-Laney P.C., Higgins P.B., Granger W., Alvarez J., Casazza K., Fernandez J.R., Dalla Man C., Cobelli

C., Gower B.A.: Use of a simple liquid meal test to evaluate insulin sensitivity and beta-cell function in children.

Pediatric Obesity 9:102-10, 2013.

408. Junqueira Vasques A.C., Pareja J.C., de Oliveira Mda S., Satake Novaes F., Miranda de Oliveira Lima M.,

Chaim É.A., Piccinini F., Dalla Man C., Cobelli C., Geloneze B.: β-Cell function improvements in grade I/II

obese subjects with type 2 diabetes 1 month after biliopancreatic diversion: results from modeling analyses of

oral glucose tolerance tests and hyperglycemic clamp studies. Diabetes Care. 36(12):4117-24, 2013.

409. Basu A., Dube S., Slama M., Errazuriz I., Amezcua J.C., Kudva Y.C., Peyser T., Carter R.E., Cobelli C., Basu

R.: Time lag of glucose from intravascular to interstitial compartment in humans. Diabetes. 62(12):4083-7, 2013.

410. Sathananthan M., Ikramuddin S., Swain J.M., Shah M., Piccinini F., Dalla Man C., Cobelli C., Rizza R.A.,

Camilleri M., Vella A.: The effect of vagal nerve blockade using electrical impulses on glucose metabolism

in nondiabetic subjects. Diabetes Metab Syndr Obes. 7:305-12, 2014. 411. Cobelli C., Renard E., Kovatchev B.: The artificial pancreas: a digital-age treatment for diabetes. Lancet

Diabetes Endocrinol 2(9):679-81, 2014. 412. Kovatchev B.P., Renard E., Cobelli C., Zisser H.C., Keith-Hynes P., Anderson S.M., Brown S.A.,

Chernavvsky D.R., Breton M.D., Mize L.B., Farret A., Place J., Bruttomesso D., Del Favero S., Boscari F.,

Galasso S., Avogaro A., Magni L., Di Palma F., Toffanin C., Messori M., Dassau E., Doyle F.J. 3rd: Safety

of outpatient closed-loop control: first randomized crossover trials of a wearable artificial pancreas. Diabetes

Care 37(7):1789-96, 2014. 413. Dalla Man C., Micheletto F., Lv D., Breton M., Kovatchev B., Cobelli C.: The UVA/PADOVA Type 1

Diabetes Simulator: New Features. J Diabetes Sci Technol. 8(1):26-34, 2014. 414. Sambo F., Malovini A., Sandholm N., Stavarachi M., Forsblom C., Mäkinen V.P., Harjutsalo V., Lithovius

R., Gordin D., Parkkonen M., Saraheimo M., Thorn L.M., Tolonen N., Wadén J., He B., Osterholm A.M.,

Tuomilehto J., Lajer M., Salem R.M., McKnight A.J.; GENIE Consortium, Tarnow L, Panduru N.M.,

Barbarini N., Di Camillo B., Toffolo G., Tryggvason K., Bellazzi R., Cobelli C., FinnDiane Study Group,

Groop PH: Novel genetic susceptibility loci for diabetic end-stage renal disease identified through robust

naive Bayes classification. Diabetologia 57(8):1611-22, 2014. 415. Cobelli C., Dalla Man C., Pedersen M.G., Bertoldo A., Toffolo G.: Advancing our understanding of the

glucose system via modeling: a perspective. IEEE Trans Biomed Eng. 61(5):1577-92, 2014. 416. Del Favero S., Bruttomesso D., Di Palma F., Lanzola G., Visentin R., Filippi A., Scotton R., Toffanin C.,

Messori M., Scarpellini S., Keith-Hynes P., Kovatchev B.P., Devries J.H., Renard E., Magni L., Avogaro A.,

Cobelli C., AP@home Consortium: First use of model predictive control in outpatient wearable artificial

pancreas. Diabetes Care 37(5):1212-5, 2014.

417. Kudva Y.C., Carter R.E., Cobelli C., Basu R., Basu A.: Closed-loop artificial pancreas systems:

physiological input to enhance next-generation devices. Diabetes Care 37(5):1184-90, 2014. 418. Del Favero S., Facchinetti A., Sparacino G., Cobelli C.: Improving accuracy and precision of glucose sensor

profiles: retrospective fitting by constrained deconvolution. IEEE Trans Biomed Eng. 61(4):1044-53, 2014. 419. Cobelli C., Dalla Man C., Toffolo G., Basu R., Vella A., Rizza R.: The oral minimal model method. Diabetes

63(4):1203-13, 2014. 420. Visentin R., Dalla Man C., Kovatchev B., Cobelli C.: The university of Virginia/Padova type 1 diabetes

simulator matches the glucose traces of a clinical trial. Diabetes Technol Ther. 16(7):428-34, 2014. 421. Schiavon M., Dalla Man C., Kudva Y.C., Basu A., Cobelli C.: Quantitative estimation of insulin sensitivity

in type 1 diabetic subjects wearing a sensor-augmented insulin pump. Diabetes Care 37(5):1216-23, 2014. 422. Goodpaster B.H., Bertoldo A., Ng J.M., Azuma K., Pencek R.R., Kelley C., Price J.C., Cobelli C., Kelley

D.E..: Interactions among glucose delivery, transport, and phosphorylation that underlie skeletal muscle

insulin resistance in obesity and type 2 Diabetes: studies with dynamic PET imaging. Diabetes 63(3):1058-

68, 2014. 423. Facchinetti A., Del Favero S., Sparacino G., Castle J.R., Ward W.K., Cobelli C.: Modeling the glucose

sensor error. IEEE Trans Biomed Eng. 61(3):620-9, 2014. 424. Shah M., Law J.H., Micheletto F., Sathananthan M., Dalla Man C., Cobelli C., Rizza R.A., Camilleri M.,

Zinsmeister A.R., Vella A.: Contribution of endogenous glucagon-like peptide 1 to glucose metabolism after

Roux-en-Y gastric bypass. Diabetes 63(2):483-93, 2014. 425. Giannini C., Dalla Man C., Groop L., Cobelli C., Zhao H., Shaw M.M., Duran E., Pierpont B. Bale A.E Caprio

S. Santoro N.:Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese

youth to prediabetes. Diabetes Care 37(2):475-82, 2014.

426. Zecchin C., Facchinetti A., Sparacino G., Cobelli C.: Jump neural network for online short-time prediction of

bloodglucose from continuous monitoring sensors and meal information. Comput Methods Programs Biomed.

113:144- 152, 2014.

427. Riz M. , Pedersen M.G., Toffolo G.M., Haschke G., Schneider H.C., Klabunde T., Margerie D., Cobelli C.:

Minimal modeling of insulin secretion in the perfused rat pancreas: a drug effect case study. Am J Physiol

Endocrinol Metab. 306(6):E627-34, 2014.

428. Di Camillo B., Sambo F., Toffolo G., Cobelli C.: ABACUS: an entropy-based cumulative bivariate statistic

robust to rare variants and different direction of genotype effect. Bioinformatics. 30(3):384-91, 2014.

429. Ng J.M., Bertoldo A., Minhas D.S., Helbling N.L., Coen P.M., Price J.C., Cobelli C., Kelley D.E., Goodpaster

B.H.: Dynamic PET imaging reveals heterogeneity of skeletal muscle insulin resistance. J Clin Endocrinol

Metab. 99(1):E102-6, 2014.

430. Brown S.A., Kovatchev B.P., Breton M.D., Anderson S.M., Keith-Hynes P., Patek S.D., Jiang B., Ben Brahim

N., Vereshchetin P., Bruttomesso D., Avogaro A., Del Favero S., Boscari F., Galasso S., Visentin R., Monaro

M., Cobelli C.: Multinight "bedside" closed-loop control for patients with type 1 diabetes. Diabetes Technology

and Therapeutics 17:203-209, 2015.

431. Cobelli C., Ursino M.: A Model Approach: Mathematical modeling provides an increasingly clear picture of

glucose and neural systems. IEEE Pulse 6: 33-38, 2015.

432. Dassau E., Brown S.A., Basu A., Pinsker J.E., Kudva Y.C., Gondhalekar R., Patek S., Lv D., Schiavon M., Lee

J.B., Dalla Man C., Hinshaw L., Castorino K., Mallad A., Dadlani V., McCrady-Spitzer S.K., McElwee-Malloy

M., Wakeman C.A., Bevier W.C., Bradley P.K., Kovatchev B., Cobelli C., Zisser H.C., Doyle F.J.: Adjustment

of open-loop settings to improve closed-loop results in type 1 diabetes: a multicenter randomized trial. Journal of

Clinical Endocrinology and Metabolism 100:3878-3886, 2015.

433. Del Favero S., Facchinetti A., Sparacino G., Cobelli C.: Retrofitting of continuous glucose monitoring traces

allows more accurate assessment of glucose control in outpatient studies. Diabetes Technology and Therapeutics

17:355-363, 2015.

434. Del Favero S., Place J., Kropff J., Messori M., Keith-Hynes P., Visentin R., Monaro M., Galasso S., Boscari F.,

Toffanin C., Di Palma F., Lanzola G., Scarpellini S., Farret A., Kovatchev B., Avogaro A., Bruttomesso D.,

Magni L., Devries J.H., Cobelli C., Renard E.: Multicenter outpatient dinner/overnight reduction of

hypoglycemia and increased time of glucose in target with a wearable artificial pancreas using modular model

predictive control in adults with type 1 diabetes. Diabetes, Obesity and Metabolism 17:468-476, 2015. 435. Fabris C., Facchinetti A., Fico G., Sambo F., Arredondo M.T., Cobelli C., MOSAIC EU Project Consortium:

Parsimonious description of glucose variability in type 2 diabetes by sparse principal component analysis.

J Diabetes Sci Technol. 10(1):119-24, 2015. 436. Facchinetti A., Del Favero S., Sparacino G., Cobelli C.: Model of glucose sensor error components: identification

and assessment for new Dexcom G4 generation devices. Medical and Biological Engineering and Computing

53:1259-1269, 2015. 437. Hakaste L.H., Sambo F., Facchinetti A., Cobelli C., Groop L.C., Tuomi T.: Continuous glucose monitoring at the

early phases of type 2 diabetes. Diabetologia 58: s184-s184, 2015.

438. Hinshaw L., Mallad A., Dalla Man C., Basu R., Cobelli C., Carter R.E., Kudva Y.C., Basu A.: Glucagon

sensitivity and clearance in type 1 diabetes: insights from in vivo and in silico experiments. Am J Physiol

Endocrinol Metab. 309(5):E474-86., 2015. 439. Javed A., Vella A., Balagopal P.B., Fischer P.R., Weaver A.L., Piccinini F., Dalla Man C., Cobelli C., Giesler

P.D., Laugen J.M., Kumar S.: Cholecalciferol supplementation does not influence β-cell function and insulin

action in obese adolescents: a prospective double-blind randomized trial. J Nutr. 145(2):284-90, 2015. 440. Javed A., Balagopal P.B., Vella A., Fischer P.R., Piccinini F., Dalla Man C., Cobelli C., Giesler P.D., Laugen

J.M., Kumar S.: Association between thyrotropin levels and insulin sensitivity in euthyroid obese adolescents.

Thyroid 25:478-484, 2015. 441. Konopka A.R., Asante A., Lanza I.R., Robinson M.M., Johnson M.L., Dalla Man C., Cobelli C., Amols M.H., Irving

B.A., Nair K.S.: Defects in mitochondrial efficiency and H2O2 emissions in obese women are restored to a lean

phenotype with aerobic exercise training. Diabetes 64:2104-2115, 2015.

442. Kovatchev B.P., Renard E., Cobelli C., Zisser H.C., Keith-Hynes P., Anderson S.M., Brown S.A., Chernavvsky

D.R., Breton M.D., Farret A., Pelletier M.J., Place J., Bruttomesso D., Del Favero S., Visentin R., Filippi A.,

Scotton R., Avogaro A., Doyle F.J.: Feasibility of outpatient fully integrated closed-loop control. Diabetes

Technology and Therapeutics 17:S31-S32, 2015. 443. Kropff J., Del Favero S., Place J., Toffanin C., Visentin R., Monaro M., Messori M., Di Palma F., Lanzola G.,

Farret A., Boscari F., Galasso S., Magni P., Avogaro A., Keith-Hynes P., Kovatchev B.P., Bruttomesso D.,

Cobelli C., DeVries J.H., Renard E., Magni L.: 2 month evening and night closed-loop glucose control in patients

with type 1 diabetes under free-living conditions: a randomised crossover trial. The Lancet Diabetes and

Endocrinology 3(12):939-947, 2015.

444. Largajolli A., Bertoldo A., Campioni M., Cobelli C.: Visual predictive check in models with time-varying input

function. AAPS Journal 17:1455-1463, 2015.

445. Mallad A., Hinshaw L., Dalla Man C., Cobelli C., Basu R., Lingineni R., Carter R.E., Kudva Y.C., Basu A.:

Nocturnal glucose metabolism in type 1 diabetes: a study comparing single versus dual tracer approaches.

Diabetes Technology and Therapeutics 17:587-595, 2015. 446. Mallad A., Hinshaw L., Schiavon M., Man C.D., Dadlani V., Basu R., Lingineni R., Cobelli C., Johnson M.L.,

Carter R., Kudva Y.C., Basu A.: Exercise effects on postprandial glucose metabolism in type 1 diabetes: A triple-

tracer approach. American Journal of Physiology - Endocrinology and Metabolism 308: E1106-E1115, 2015. 447. Dalla Man C., Pillonetto G., Riz M., Cobelli C.: An index of parameter reproducibility accounting for estimation

uncertainty: theory and case study on β-cell responsivity and insulin sensitivity. American Journal of Physiology

Endocrinology and Metabolism 308:E971-E977, 2015. 448. Mantoan A., Pizzolato C., Sartori M., Sawacha Z., Cobelli C., Reggiani M.: MOtoNMS: A MATLAB toolbox to

process motion data for neuromusculoskeletal modeling and simulation. Source Code for Biology and Medicine

16:10-12, 2015. 449. Marini S., Trifoglio E., Barbarini N., Sambo F., Di Camillo B., Malovini A., Manfrini M., Cobelli C., Bellazzi

R.: A dynamic bayesian network model for long-term simulation of clinical complications in type 1 diabetes.

Journal of Biomedical Informatics 57:369-376, 2015. 450. Sathananthan M., Shah M., Edens K.L., Grothe K.B., Piccinini F., Farrugia L.P., Micheletto F., Man C.D.,

Cobelli C., Rizza R.A., Camilleri M., Vella A.: Six and 12 weeks of caloric restriction increases β cell function

and lowers fasting and postprandial glucose concentrations in people with type 2 diabetes. J Nutr. 145(9):2046-

51, 2015. 451. Schiavon M., Dalla Man C., Dube S., Slama M., Kudva Y.C., Peyser T., Basu A., Basu R., Cobelli C.: Modeling

plasma-to-interstitium glucose kinetics from multitracer plasma and microdialysis data. Diabetes Technology and

Therapeutics 17:825-831, 2015. 452. Tanaka K., Saisho Y., Manesso E., Tanaka M., Meguro S., Irie J., Sugiura H., Kawai T., Jinzaki M., Cobelli C.,

Itoh H.: Effects of liraglutide monotherapy on beta cell function and pancreatic enzymes compared with

metformin in japanese overweight/obese patients with type 2 diabetes mellitus: a subpopulation analysis of the

KIND-LM Randomized Trial. Clinical Drug Investigation 35:675-684, 2015. 453. Vasques A.C.J., Pareja J.C., Souza J.R.M., Yamanaka A., de Oliveira M.S., Novaes F.S., Chaim Ã.A., Piccinini

F., Dalla Man C., Cobelli C., Geloneze B.: Epicardial and pericardial fat in type 2 diabetes: favourable effects of

biliopancreatic diversion. Obesity Surgery 25:477-485, 2015. 454. Vella A., Cobelli C.: Defective glucagon-like peptide 1 secretion in prediabetes and type 2 diabetes is influenced

by weight and sex. chicken, egg, or none of the above?. Diabetes. 64(7):2324-5, 2015.

455. Visentin R., Dalla Man C., Basu R., Basu A., Rizza R.A., Cobelli C.: Hepatic insulin sensitivity in healthy and

prediabetic subjects: From a dual- to a single-tracer oral minimal model. American Journal of Physiology

Endocrinology and Metabolism 309:E161-E167, 2015.

456. Visentin R., Dalla Man C., Kudva Y.C., Basu A., Cobelli C.: Circadian variability of insulin sensitivity:

Physiological input for in silico artificial pancreas. Diabetes Technology and Therapeutics 17:1-7, 2015.

457. Zheng C., Dalla Man C., Cobelli C., Groop L., Zhao H., Bale A.E., Shaw M., Duran E., Pierpont B., Caprio S.,

Santoro N.: A common variant in the MTNR1b gene is associated with increased risk of impaired fasting glucose

(IFG) in youth with obesity. 2015. Obesity 23:1022-1029, 2015.

458. Basu A., Dube S., Veetil S., Slama M., Kudva Y.C., Peyser T., Carter R.E., Cobelli C., Basu R.: Time lag of

glucose from intravascular to interstitial comportament in type 1 diabetes. J Diabetes Sci Technol. 9(1):63-8,

2015.

459. Zecchin C., Facchinetti A., Sparacino G., Cobelli C: Jump neural network for real-time prediction of glucose

concentration. Methods in Molecular Biology 1260:245-259, 2015.

460. Del Favero, S., Bruttomesso, D., Cobelli, C. Articial pancreas: a review of fundamentals and inpatient and out

patient studies. Frontiers in Diabetes, 2015, Vol. 24 pp. 166-189.

461. Kovatchev B., Cobelli C.: Glucose Variability: Timing, Risk Analysis, and Relationship to Hypoglycemia in

Diabetes. Diabetes Care 39(4): 502-510, 2016.

462. Gonder-Frederick L.A., Grabman J. H., Kovatchev B., Brown S. A., Patek S., Basu A., Pinsker J. E., Kudva

Y. C., Wakeman C.A., Dassau E., Cobelli C., Zisser H. C., Doyle F. J. : Is psychological stress a factor for

incorporation into future closed-loop systems?. Journal of Diabetes Science and Technology 10(3):640-646,

2016.

463. Deiss D., Adolfsson A., Alkemade-Van Zomeren M., Bolli G. B., Charpentier G., Cobelli C., Danne T., Girelli

A., Mueller H., Verderese C. A., Renard E.: Insulin infusion set use: european perspectives and

recommendations. Diabetes Technology & Therapeutics 18(9): 517-524, 2016.

464. Vella A., Cobelli C.: Exocrine and endocrine interactions in cystic fibrosis a potential key to understanding

insulin secretion in health and disease?. Diabetes 66:1-3, 2016.

465. Rubega M., Sparacino G., Sejling A.S., Juhl C.B., Cobelli C.: Hypoglycemia-induced decrease of EEG

coherence in patients with type 1 diabetes. Diabetes Technol Ther. 18(3):178-84, 2016.

466. Dalla Man C., Micheletto F., Sathananthan M., Vella A., Cobelli C.: Model-based quantification of Glucagon-

like Peptide-1-induced potentiation of insulin secretion in response to a mixed meal challenge. Diabetes Technol

Ther. 18(1):39-46, 2016.

467. Facchinetti A., Del Favero S., Sparacino G., Cobelli C.: Modeling transient disconnections and compression

artifacts of continuous glucose sensors. Diabetes Technol Ther. 18(4):264-72, 2016.

468. Sandrini M., Manenti R., Brambilla M., Cobelli C., Cohen L.G., Cotelli M.: Older adults get episodic memory

boosting from noninvasive stimulation of prefrontal cortex during learning. Neurobiol Aging. 39:210-6, 2016.

469. Hinshaw L., Schiavon M., Dadlani V., Mallad A., Dalla Man C., Bharucha A., Basu R., Geske J.R., Carter R.E.,

Cobelli C., Basu A., Kudva Y.C.: Effect of pramlintide on postprandial glucose fluxes in type 1 diabetes. J Clin

Endocrinol Metab. 101(5):1954-62, 2016.

470. Scarton A., Sawacha Z., Cobelli C., Li X.: Towards the generation of a parametric foot model using principal

component analysis: A pilot study. Med Eng Phys. 38(6):547-59, 2016.

471. Konopka A.R., Esponda R.R., Robinson M.M., Johnson M.L., Carter R.E., Schiavon M., Cobelli C., Wondisford

F.E., Lanza I.R., Nair K.S.: Hyperglucagonemia mitigates the effect of metformin on glucose production in

prediabetes. cell rep. 15(7):1394-400, 2016.

472. Shaw N.D., McHill A.W., Schiavon M., Kangarloo T., Mankowski P.W., Cobelli C., Klerman E.B., Hall J.E.:

Effect of slow wave sleep disruption on metabolic parameters in adolescents. Sleep 39(8):1591-9, 2016.

473. Siebel A.L., Trinh S.K., Formosa M.F., Mundra P.A., Natoli A.K., Reddy-Luthmoodoo M., Huynh K., Khan

A.A., Carey A.L., van Hall G., Cobelli C., DallaMan C., Otvos J.D., Rye K.A., Johansson J., Gordon A., Wong

N.C., Sviridov D., Barter P., Duffy S.J., Meikle P.J., Kingwell B.A.: Effects of the BET-inhibitor, RVX-208 on

the HDL lipidome and glucose metabolism in individuals with prediabetes: A randomized controlled trial.

Metabolism 65(6):904-14, 2016.

474. Rizza R.A., Toffolo G., Cobelli C.: Accurate measurement of postprandial glucose turnover: why is it difficult

and how can it be done (relatively) simply?. Diabetes 65(5):1133-45, 2016.

475. Anderson S.M., Raghinaru D., Pinsker J.E., Boscari F., Renard E., Buckingham B.A., Nimri R., Doyle F.J. 3rd,

Brown S.A., Keith-Hynes P., Breton M.D., Chernavvsky D., Bevier W.C., Bradley P.K., Bruttomesso D., Del

Favero S., Calore R., Cobelli C., Avogaro A., Farret A., Place J., Ly T.T., Shanmugham S., Phillip M., Dassau

E., Dasanayake I.S., Kollman C., Lum J.W., Beck R.W., Kovatchev B., Control to Range Study Group.:

Multinational home use of closed-loop control is safe and effective. Diabetes Care 39(7):1143-50, 2016.

476. Renard E., Farret A., Kropff J., Bruttomesso D., Messori M., Place J., Visentin R., Calore R., Toffanin C., Di

Palma F., Lanzola G., Magni P., Boscari F., Galasso S., Avogaro A., Keith-Hynes P., Kovatchev B., Del Favero

S., Cobelli C., Magni L., DeVries J.H., AP@home Consortium.: Day-and-night closed-loop glucose control in

patients with type 1 diabetes under free-living conditions: results of a single-arm 1-month experience compared

with a previously reported feasibility study of evening and night at home. Diabetes Care 39(7):1151-60, 2016.

477. Del Favero S., Boscari F., Messori M., Rabbone I., Bonfanti R., Sabbion A., Iafusco D., Schiaffini R., Visentin

R., Calore R., Moncada Y.L., Galasso S., Galderisi A., Vallone V., Di Palma F., Losiouk E., Lanzola G., Tinti

D., Rigamonti A., Marigliano M., Zanfardino A., Rapini N., Avogaro A., Chernavvsky D., Magni L., Cobelli C.,

Bruttomesso D.: Randomized summer camp crossover trial in 5- to 9-year-old children: outpatient wearable

artificial pancreas is feasible and safe. Diabetes Care 39(7):1180-5, 2016.

478. Cobelli C., Schiavon M., Dalla Man C., Basu A., Basu R.: Interstitial fluid glucose is not just a shifted-in-time

but a distorted mirror of blood glucose: insight from an in silico study. Diabetes Technol Ther. 18(8):505-11,

2016.

479. Kovatchev B., Tamborlane W.V., Cefalu W.T., Cobelli C.: The artificial pancreas in 2016: a digital treatment

ecosystem for diabetes. Diabetes Care 39(7):1123-6, 2016.

480. Visentin R., Giegerich C., Jäger R., Dahmen R., Boss A., Grant M., Dalla Man C., Cobelli C., Klabunde T.:

Improving efficacy of inhaled technosphere insulin (afrezza) by postmeal dosing: in-silico clinical trial with the

university of Virginia/Padova type 1 diabetes simulator. Diabetes Technol Ther. 18(9):574-85, 2016.

481. Zecchin C., Facchinetti A., Sparacino G., Cobelli C.: How much is short-term glucose prediction in type 1

diabetes improved by adding insulin delivery and meal content information to CGM data? A proof-of-concept

study. J Diabetes Sci Technol. 10(5):1149-60, 2016.

482. Shankar S.S., Vella A., Raymond R.H., Staten M.A., Calle R.A., Bergman R.N., Cao C., Chen D., Cobelli C.,

Dalla Man C., Deeg M., Dong J.Q., Lee D.S., Polidori D., Robertson R.P., Ruetten H., Stefanovski D., Vassileva

M.T., Weir G.C., Fryburg D.A., Foundation for the National Institutes of Health β-Cell Project Team.:

Standardized mixed-meal tolerance and arginine stimulation tests provide reproducible and complementary

measures of β-Cell function: results from the foundation for the national institutes of health biomarkers

consortium investigative series. Diabetes Care 39(9):1602-13, 2016.

483. Messori M., Toffanin C., Del Favero S., De Nicolao G., Cobelli C., Magni L.: Model individualization for

artificial pancreas. Comput Methods Programs Biomed. S0169-2607(15) [Epub ahead of print], 2016.

484. Acciaroli G., Vettoretti M., Facchinetti A., Sparacino G., Cobelli C.: From two to one per day calibration of

dexcom G4 platinum by a time-varying day-specific bayesian prior. Diabetes Technol Ther. 18(8):472-9, 2016.

485. Deiss D., Adolfsson P., Alkemade-van Zomeren M., Bolli G.B., Charpentier G., Cobelli C., Danne T., Girelli A.,

Mueller H., Verderese C.A., Renard E.: Insulin infusion set use: european perspectives and recommendations.

Diabetes Technol Ther. 18(9):517-24, 2016.

486. Kovatchev B., Cobelli C.: Response to comment on Kovatchev and Cobelli. Glucose variability: timing, risk

analysis, and relationship to hypoglycemia in diabetes. Diabetes Care 39:502-510 39(9):e157-8., 2016.

487. Varghese R.T, Dalla Man C., Sharma A., Viegas I., Barosa C., Marques C., Shah M., Miles J.M., Rizza R.A.,

Jones J.G., Cobelli C., Vella A.: Mechanisms underlying the pathogenesis of isolated impaired glucose tolerance

in humans. J Clin Endocrinol Metab. 101(12):4816-4824, 2016.

488. Spolaor F., Sawacha Z., Guarneri G., Del Din S., Avogaro A., Cobelli C.: Altered EMG patterns in diabetic

neuropathic and not neuropathic patients during step ascending and descending. J Electromyogr Kinesiol. 31:32-

39, 2016.

489. Sandholm N., Van Zuydam N., Ahlqvist E., Juliusdottir T., Deshmukh H.A., Rayner N.W., Di Camillo B.,

orsblom C., Fadista J., Ziemek D., Salem R.M., Hiraki L.T., Pezzolesi M., Trégouët D., Dahlström E., Valo E.,

Oskolkov N., Ladenvall C., Marcovecchio M.L., Cooper J., Sambo F., Malovini A., Manfrini M., McKnight

A.J., Lajer M., Harjutsalo V., Gordin D., Parkkonen M., FinnDiane Study Group., Tuomilehto J., Lyssenko V.,

McKeigue P.M., Rich S.S., Brosnan M.J., Fauman E., Bellazzi R., Rossing P., Hadjadj S., Krolewski A.,

Paterson AD., DCCT/EDIC Study Group., Florez J.C., Hirschhorn J.N., Maxwell AP., GENIE Consortium.,

Dunger D., Cobelli C., Colhoun H.M., Groop L., McCarthy M.I., Groop P.H., SUMMIT Consortium.: The

genetic landscape of renal complications in type 1 diabetes. J Am Soc Nephrol. pii: ASN.2016020231. [Epub

ahead of print], 2016.

490. Vasques A.C., Pareja J.C., da Saúde de Oliveira M., Novaes F.S., Lima M.M., Chaim É.A., Piccinini F., Dalla

Man C., Cobelli C., Geloneze B.: Long-term outcomes of biliopancreatic diversion on glycemic control, insulin

sensitivity and Beta cell function. Obes Surg. 26(11):2572-2580., 2016.

491. Visentin R., Dalla Man C., Cobelli C.: One-day bayesian cloning of type 1 diabetes subjects: toward a single-day

UVA/Padova type 1 diabetes simulator. IEEE Trans Biomed Eng. 63(11):2416-2424, 2016.

492. Troncone A., Bonfanti R., Iafusco D., Rabbone I., Sabbion A., Schiaffini R., Galderisi A., Marigliano M., Rapini

N., Rigamonti A., Tinti D., Vallone V., Zanfardino A., Boscari F., Del Favero S., Galasso S., Lanzola G.,

Messori M., Di Palma F., Visentin R., Calore R., Leal Y., Magni L., Losiouk E., Chernavvsky D., Quaglini S.,

Cobelli C., Bruttomesso D.: Evaluating the experience of children with type 1 diabetes and their parents taking

part in an artificial pancreas clinical trial over multiple days in a diabetes camp setting. Diabetes Care

39(12):2158-2164, 2016.

493. Vettoretti M., Facchinetti A., Sparacino G., Cobelli C.: Predicting insulin treatment scenarios with the net effect

method: domain of validity. Diabetes Technol Ther. 18(11):694-704, 2016.

494. Lanzola G., Losiouk E., Del Favero S., Facchinetti A., Galderisi A., Quaglini S., Magni L., Cobelli C.: Remote

blood glucose monitoring in mhealth scenarios: a review. Sensors (Basel) 16(12). E1983, 2016.

495. Galderisi A., Brigadoi S., Cutini S., Moro S.B., Lolli E., Meconi F., Benavides-Varela S., Baraldi E., Amodio P.,

Cobelli C., Trevisanuto D., Dell'Acqua R.: Long-term continuous monitoring of the preterm brain with diffuse

optical tomography and electroencephalography: a technical note on cap manufacturing. Neurophotonics

3(4):045009, 2016.

496. Newhouse L. P., Joyner M. J., Curry T. B., Laurenti M. C., Dalla Man C., Cobelli C., Vella A., Limberg J. K.:

Three hours of intermittent hypoxia increases circulating glucose levels in healthy adults. Physiological Reports

5:e13106, 2017.

497. Wang Y., Zhang J., Zeng F., Wang N., Chen X., Zhang B., Zhao D., Yang W., Cobelli C.: "Learning" Can

improve the blood glucose control performance for type 1 diabetes mellitus. Diabetes Technol Ther. 19(1):41-48,

2017.

498. Manenti R, Sandrini M, Gobbi E, Cobelli C, Brambilla M, Binetti G, Cotelli M. Strengthening of Existing

Episodic Memories Through Non-invasive Stimulation of Prefrontal Cortex in Older Adults with Subjective

Memory Complaints. Front Aging Neurosci. 2017 Dec 5;9:401. doi: 10.3389/fnagi.2017.00401. eCollection

2017. PubMed PMID: 29259554; PubMed Central PMCID: PMC5723311.

499. Cobelli C., Vella A.: Exocrine and Endocrine Interactions in Cystic Fibrosis: A Potential Key to Understanding

Insulin Secretion in Health and Disease?. Diabetes. 66(1):20-22, 2017.

500. Kovatchev B., Cheng P., Anderson S.M., Pinsker J.E., Boscari F., Buckingham B.A., Doyle F.J. 3rd, Hood K.K.,

Brown S.A., Breton M.D., Chernavvsky D., Bevier W.C., Bradley P.K.., Bruttomesso D., Del Favero S., Calore

R., Cobelli C., Avogaro A., Ly T.T., Shanmugham S., Dassau E., Kollman C., Lum J.W., Beck R.W.: Feasibility

of Long-Term Closed-Loop Control: A Multicenter 6-Month Trial of 24/7 Automated Insulin Delivery. Diabetes

Technol Ther. 19(1):18-24, 2017.

501. Hodson K., Dalla Man C., Smith F.E., Barnes A., McParlin C., Cobelli C., Robson S.C., Araújo-Soares V.,

Taylor R.: Liver triacylglycerol content and gestational diabetes: effects of moderate energy restriction.

Diabetologia 60(2):306-313, 2017.

502. Kropff J., DeJong J., Del Favero S., Place J., Messori M., Coestier B., Farret A., Boscari F., Galasso S., Avogaro

A., Bruttomesso D., Cobelli C., Renard E., Magni L., DeVries J.H. AP@home consortium.: Psychological

outcomes of evening and night closed-loop insulin delivery under free living conditions in people with Type 1

diabetes: a 2-month randomized crossover trial. Diabet Med. 34(2):262-271, 2017.

503. Klement J., Ott V., Rapp K., Brede S., Piccinini F., Cobelli C., Lehnert H., Hallschmid M.: Oxytocin improves

β-Cell responsivity and glucose tolerance in healthy men. Diabetes 66(2):264-271, 2017.

504. Dal Favero S., Facchinetti A., Sparacino G., Cobelli C.: Retrofitting real-life Dexcom G5 Data. Diabetes

Technol Ther. 19(4):237-245, 2017.

505. Viceconti M., Cobelli C., Haddad T., Himes A., Kovatchev B., Palmer M.: In silico assessment of biomedical

products: The conundrum of rare but not so rare events in two case studies. Proc Inst Mech Eng H. 231(5):455-

466, 2017.

506. Errazuriz I., Dube S., Slama M., Visentin R., Nayar S., O'Connor H., Cobelli C., Das S.K., Basu A., Kremers

W.K., Port J., Basu R.: Randomized controlled trial of a MUFA or fiber-rich diet on hepatic fat in prediabetes. J

Clin Endocrinol Metab 102(5):1765-1774, 2017.

507. Vettoretti M., Facchinetti A., Sparacino G., Cobelli C.: A Model of self-monitoring blood glucose measurement

error. J Diabetes Sci Technol. 11(4):724-735, 2017.

508. Fico G., Hernández L., Cancela J., Isabel M.M., Facchinetti A., Fabris C., Gabriel R., Cobelli C., Arredondo

Waldmeyer M.T.: Exploring the frequency domain of continuous glucose monitoring signals to improve

characterization of glucose variability and of diabetic profiles. J Diabetes Sci Technol. 11(4):773-779, 2017.

509. Sharma A., Laurenti M.C., Dalla Man C., Varghese R.T., Cobelli C., Rizza R.A., Matveyenko A., Vella A.:

Glucose metabolism during rotational shift-work in healthcare workers. Diabetologia 60(8):1483-1490, 2017.

510. Cropano C., Santoro N., Groop L., Dalla Man C., Cobelli C., Galderisi A., Kursawe R., Pierpont B., Goffredo

M., Caprio S.: The rs7903146 variant in the TCF7L2 gene increases the risk of prediabetes/type 2 diabetes in

obese adolescents by impairing β-Cell function and hepatic insulin sensitivity. Diabetes Care 40(8):1082-1089,

2017.

511. Galderisi A., Facchinetti A., Steil G.M., Ortiz-Rubio P., Cavallin F., Tamborlane W.V., Baraldi E., Cobelli C.,

Trevisanuto D.: Continuous glucose monitoring in very preterm infants: a randomized controlled trial. Pediatrics

140(4), 2017.

512. Brown S.A., Breton M.D., Anderson S.M., Kollar L., Keith-Hynes P., Levy C.J., Lam D.W., Levister C., Baysal

N., Kudva Y.C., Basu A., Dadlani V., Hinshaw L., McCrady-Spitzer S., Bruttomesso D., Visentin R., Galasso

S., Del Favero S., Leal Y., Boscari F., Avogaro A., Cobelli C., Kovatchev B.P.: Overnight closed-loop control

improves glycemic control in a multicenter study of adults with type 1 diabetes. J Clin Endocrinol Metab.

102(10):3674-3682, 2017.

513. Scarton A., Jonkers I., Guiotto A., Spolaor F., Guarneri G., Avogaro A., Cobelli C., Sawacha Z.: Comparison of

lower limb muscle strength between diabetic neuropathic and healthy subjects using OpenSim. Gait Posture

58:194-200, 2017.

514. Scarton A, Guiotto A, Malaquias T, Spolaor F, Sinigaglia G, Cobelli C, Jonkers I, Sawacha Z. A methodological

framework for detecting ulcers' risk in diabetic foot subjects by combining gait analysis, a new musculoskeletal

foot model and a foot finite element model. Gait Posture. 2018 Feb;60:279-285. doi:

10.1016/j.gaitpost.2017.08.036. Epub 2017 Sep 1. PubMed PMID: 28965863.

515. Aerts W, Scarton A, De Groote F, Guiotto A, Sawacha Z, Cobelli C, Vander Sloten J, Jonkers I. Validation of

plantar pressure simulations using finite and discrete element modelling in healthy and diabetic subjects.

Comput Methods Biomech Biomed Engin. 2017 Oct;20(13):1442-1452. doi: 10.1080/10255842.2017.1372428.

Epub 2017 Sep 12. PubMed PMID: 28895759.

516. Faccioli S., Del Favero S., Visentin R., Bonfanti R., Iafusco D., Rabbone I., Marigliano M., Schiaffini R.,

Bruttomesso D., Cobelli C, PedArPan Study Group: Accuracy of a CGM sensor in pediatric subjects with type 1

diabetes. comparison of three insertion sites: arm, abdomen, and gluteus. J Diabetes Sci Technol. 11(6):1147-

1154, 2017.

517. Pievani M, Pini L, Ferrari C, Pizzini FB, Boscolo Galazzo I, Cobelli C, Cotelli M, Manenti R, Frisoni GB.

Coordinate-Based Meta-Analysis of the Default Mode and Salience Network for Target Identification in Non-

Invasive Brain Stimulation of Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Networks.

J Alzheimers Dis. 2017;57(3):825-843. doi: 10.3233/JAD-161105. PubMed PMID: 28304293.

518. Dassau E., Pinsker J.E., Kudva Y.C., Brown S.A., Gondhalekar R., Dalla Man C., Patek S., Schiavon M.,

Dadlani V., Dasanayake I., Church M.M., Carter R.E., Bevier W.C., Huyett L.M., Hughes J., Anderson S., Lv

D., Schertz E., Emory E., McCrady-Spitzer S.K., Jean T., Bradley P.K., Hinshaw L., Laguna Sanz A.J., Basu A.,

Kovatchev B., Cobelli C., Doyle F.J. 3rd.: Twelve-week 24/7 ambulatory artificial pancreas with weekly

adaptation of insulin delivery settings: effect on hemoglobin A(1c) and hypoglycemia. Diabetes Care

40(12):1719-1726, 2017.

519. Sandholm N., Van Zuydam N., Ahlqvist E., Juliusdottir T., Deshmukh H.A., Rayner N.W., Di Camillo B.,

Forsblom C., Fadista J., Ziemek D., Salem R.M., Hiraki L.T., Pezzolesi M., Trégouët D., Dahlström E., Valo E.,

Oskolkov N., Ladenvall C., Marcovecchio M.L., Cooper J., Sambo F., Malovini A., Manfrini M., McKnight

A.J., Lajer M., Harjutsalo V., Gordin D., Parkkonen M; FinnDiane Study Group, Jaakko Tuomilehto, Lyssenko

V., McKeigue P.M., Rich S.S., Brosnan M.J., Fauman E., Bellazzi R., Rossing P., Hadjadj S., Krolewski A.,

Paterson A.D.; DCCT/EDIC Study Group, Jose C. Florez, Hirschhorn JN, Maxwell AP; GENIE Consortium,

David Dunger, Cobelli C., Colhoun H.M., Groop L., McCarthy M.I., Groop P.H.; SUMMIT Consortium. The

Genetic Landscape of Renal Complications in Type 1 Diabetes. J Am Soc Nephrol. 28(2):557-574, 2017.

520. Danne T, Nimri R, Battelino T, Bergenstal RM, Close KL, DeVries JH, Garg S, Heinemann L, Hirsch I, Amiel

SA, Beck R, Bosi E, Buckingham B, Cobelli C, Dassau E, Doyle FJ 3rd, Heller S, Hovorka R, Jia W, Jones T,

Kordonouri O, Kovatchev B, Kowalski A, Laffel L, Maahs D, Murphy HR, Nørgaard K, Parkin CG, Renard E,

Saboo B, Scharf M, Tamborlane WV, Weinzimer SA, Phillip M. International Consensus on Use of Continuous

Glucose Monitoring. Diabetes Care. 2017 Dec;40(12):1631-1640. doi: 10.2337/dc17-1600. Review. PubMed

PMID: 29162583; PubMed Central PMCID: PMC6467165.

521. Van Zuydam N.R., Ahlqvist E., Sandholm N., Deshmukh H., Rayner N.W., Abdalla M., Ladenvall C., Ziemek

D., Fauman E., Robertson N.R., McKeigue P.M., Valo E., Forsblom C., Harjutsalo V.; Finnish Diabetic

Nephropathy Study (FinnDiane), Perna A., Rurali E., Marcovecchio M.L., Igo RP Jr., Salem R.M., Perico N.,

Lajer M., Käräjämäki A., Imamura M., Kubo M., Takahashi A., Sim X., Liu J., van Dam R.M., Jiang G., Tam

C.H.T., Luk A.O.Y., Lee H.M., Lim C.K.P., Szeto C.C., So W.Y., Chan J.C.N.; Hong Kong Diabetes Registry

Theme-based Research Scheme Project Group, Ang S.F., Dorajoo R., Wang L., Clara T.S.H., McKnight A.J.,

Duffy S.; Warren 3 and Genetics of Kidneys in Diabetes (GoKinD) Study Group, Pezzolesi M.G.; GENIE

(GEnetics of Nephropathy an International Effort) Consortium, Marre M., Gyorgy B., Hadjadj S., Hiraki L.T.;

Diabetes Control and Complications Trial (DCCT)/Epidemiology of Diabetes Interventions and Complications

(EDIC) Research Group, Ahluwalia T.S., Almgren P., Schulz C.A., Orho-Melander M., Linneberg A.,

Christensen C., Witte D.R., Grarup N., Brandslund I., Melander O., Paterson A.D., Tregouet D., Maxwell A.P.,

Lim S.C., Ma R.C.W., Tai E.S., Maeda S., Lyssenko V., Tuomi T., Krolewski A.S., Rich S.S., Hirschhorn J.N.,

Florez J.C., Dunger D., Pedersen O., Hansen T., Rossing P., Remuzzi G.; SUrrogate markers for Micro- and

Macrovascular hard endpoints for Innovative diabetes Tools (SUMMIT) Consortium, Brosnan M.J., Palmer

C.N.A., Groop P.H., Colhoun H.M., Groop L.C., McCarthy M.I..: A Genome-Wide Association Study of

Diabetic Kidney Disease in Subjects With Type 2 Diabetes. Diabetes 67(7):1414-1427, 2018.

522. Moran A, Toffolo G, Schiavon M, Vella A, Klaus K, Cobelli C, Nair KS. A novel triple-tracer approach to

assess postprandial protein turnover. Am J Physiol Endocrinol Metab. 2018 Oct 1;315(4):E469-E477. doi:

10.1152/ajpendo.00012.2018. Epub 2018 Jun 5. PubMed PMID: 29870679; PubMed Central PMCID:

PMC6230707.

523. Qian J, Dalla Man C, Morris CJ, Cobelli C, Scheer FAJL. Differential effects of the circadian system and

circadian misalignment on insulin sensitivity and insulin secretion in humans. Diabetes Obes Metab. 2018

Oct;20(10):2481-2485. doi: 10.1111/dom.13391. Epub 2018 Jul 2. PubMed PMID: 29862620; PubMed Central

PMCID: PMC6167165.

524. Vettoretti M., Facchinetti A., Sparacino G., Cobelli C.: Type-1 Diabetes Patient Decision Simulator for In Silico

Testing Safety and Effectiveness of Insulin Treatments. IEEE Trans Biomed Eng. 65(6):1281-1290, 2018.

525. Galderisi A, Lago P, Steil GM, Ghirardo M, Cobelli C, Baraldi E, Trevisanuto D. Procedural Pain during

Insertion of a Continuous Glucose Monitoring Device in Preterm Infants. J Pediatr. 2018 Sep;200:261-264.e1.

doi: 10.1016/j.jpeds.2018.03.040. Epub 2018 May 31. PubMed PMID: 29861315.

526. Purnell J.Q., Johnson G.S., Wahed A.S., Dalla Man C., Piccinini F., Cobelli C., Prigeon R.L., Goodpaster B.H.,

Kelley D.E., Staten M.A., Foster-Schubert K.E., Cummings D.E., Flum D.R., Courcoulas A.P., Havel P.J.,

Wolfe B.M.: Prospective evaluation of insulin and incretin dynamics in obese adults with and without diabetes

for 2 years after Roux-en-Y gastric bypass. Diabetologia 61(5):1142-1154, 2018.

527. Di Camillo B., Hakaste L., Sambo F., Gabriel R., Kravic J., Isomaa B., Tuomilehto J., Alonso M., Longato E.,

Facchinetti A., Groop L.C., Cobelli C., Tuomi T.: HAPT2D: high accuracy of prediction of T2D with a model

combining basic and advanced data depending on availability. Eur J Endocrinol. 331-341 ,2018.

528. Chouinard VA, Henderson DC, Dalla Man C, Valeri L, Gray BE, Ryan KP, Cypess AM, Cobelli C, Cohen BM,

Öngür D. Impaired insulin signaling in unaffected siblings and patients with first-episode psychosis. Mol

Psychiatry. 2019 Oct;24(10):1513-1522. doi: 10.1038/s41380-018-0045-1. Epub 2018 Mar 9. PubMed PMID:

29523870; PubMed Central PMCID: PMC6129440.

529. Varghese R.T., Dalla Man C., Laurenti M.C., Piccinini F., Sharma A., Shah M., Bailey K.R., Rizza R.A., Cobelli

C., Vella A.: Performance of individually measured vs population-based C-peptide kinetics to assess β-cell

function in the presence and absence of acute insulin resistance. Diabetes Obes Metab. 20(3):549-555, 2018.

530. Losiouk E, Lanzola G, Del Favero S, Boscari F, Messori M, Rabbone I, Bonfanti R, Sabbion A, Iafusco D,

Schiaffini R, Visentin R, Galasso S, Di Palma F, Chernavvsky D, Magni L, Cobelli C, Bruttomesso D, Quaglini

S. Parental evaluation of a telemonitoring service for children with Type 1 Diabetes. J Telemed Telecare. 2018

Apr;24(3):230-237. doi: 10.1177/1357633X17695172. Epub 2017 Mar 26. PubMed PMID: 28345384.

531. Acciaroli G., Vettoretti M., Facchinetti A., Sparacino G., Cobelli C.: Reduction of Blood Glucose Measurements

to Calibrate Subcutaneous Glucose Sensors: A Bayesian Multiday Framework. IEEE Trans Biomed Eng.

65(3):587-595, 2018.

532. Acciaroli G, Sparacino G, Hakaste L, Facchinetti A, Di Nunzio GM, Palombit A, Tuomi T, Gabriel R, Aranda J,

Vega S, Cobelli C. Diabetes and Prediabetes Classification Using Glycemic Variability Indices From Continuous

Glucose Monitoring Data. J Diabetes Sci Technol. 2018 Jan;12(1):105-113. doi: 10.1177/1932296817710478.

Epub 2017 Jun 1. PubMed PMID: 28569077; PubMed Central PMCID: PMC5761967.

533. Toffanin C., Visentin R., Messori M., Palma F.D., Magni L., Cobelli C.: Toward a Run-to-Run Adaptive

Artificial Pancreas: In Silico Results. IEEE Trans Biomed Eng. 65(3):479-488, 2018.

534. Visentin R., Campos-Náñez E., Schiavon M., Lv D., Vettoretti M., Breton M., Kovatchev B.P., Dalla Man C.,

Cobelli C.: The UVA/Padova Type 1 Diabetes Simulator Goes From Single Meal to Single Day. J Diabetes Sci

Technol. 12(2):273-281, 2018.

535. Schiavon M., Dalla Man C., Cobelli C.: Insulin Sensitivity Index-Based Optimization of Insulin to Carbohydrate

Ratio: In Silico Study Shows Efficacious Protection Against Hypoglycemic Events Caused by Suboptimal

Therapy. Diabetes Technol Ther. 20(2):98-105, 2018.

536. Sharma A., Varghese R.T., Shah M,. Dalla Man C., Cobelli C., Rizza R.A., Bailey K.R., Vella A.: Impaired

Insulin Action Is Associated With Increased Glucagon Concentrations in Nondiabetic Humans. J Clin

Endocrinol Metab 103(1):314-319, 2018.

537. Shankara S.S., Lee D.S., Raymond R.H., Calle R.A., Cobell C., Ghosh A., Robertson R.P., Ruetten H., Staten

M.A., Stefanovski D., Vella A., Whitaker S., Fryburg D.A.: Outpatient versus inpatient mixed meal tolerance

and arginine stimulation testing yields comparable measures of variability for assessment of beta cell function.

Contemporary Clinical Trias Communications 10: 94-99, 2018.

538. Cobelli C, Facchinetti A. Yet Another Glucose Variability Index: Time for a Paradigm Change? Diabetes

Technol Ther. 2018 Jan;20(1):1-3. doi: 10.1089/dia.2017.0397. PubMed PMID: 29320256.

539. Konopka AR, Esponda RR, Robinson MM, Johnson ML, Carter RE, Schiavon M, Cobelli C, Wondisford FE,

Lanza IR, Nair KS. Hyperglucagonemia Mitigates the Effect of Metformin on Glucose Production in

Prediabetes. Cell Rep. 2018 May 22;23(8):2532. doi: 10.1016/j.celrep.2018.05.027. PubMed PMID: 29791861;

PubMed Central PMCID: PMC6143136.

540. Schiavon M, Dalla Man C, Cobelli C. Modeling Subcutaneous Absorption of Fast-Acting Insulin in Type 1

Diabetes. IEEE Trans Biomed Eng. 2018 Sep;65(9):2079-2086. doi: 10.1109/TBME.2017.2784101. Epub 2017

Dec 15. PubMed PMID: 29989928.

541. Shankar SS, Lee DS, Raymond RH, Calle RA, Cobelli C, Ghosh A, Robertson RP, Ruetten H, Staten MA,

Stefanovski D, Vella A, Whitaker S, Fryburg DA; Foundation for the NIH Biomarkers Consortium Beta Cell

Project Team. Outpatient versus inpatient mixed meal tolerance and arginine stimulation testing yields

comparable measures of variability for assessment of beta cell function. Contemp Clin Trials Commun. 2018

Mar 29;10:94-99. doi: 10.1016/j.conctc.2018.03.009. eCollection 2018 Jun. PubMed PMID: 30023442; PubMed

Central PMCID: PMC6047312.

542. Manenti R, Cotelli MS, Cobelli C, Gobbi E, Brambilla M, Rusich D, Alberici A, Padovani A, Borroni B, Cotelli

M. Transcranial direct current stimulation combined with cognitive training for the treatment of Parkinson

Disease: A randomized, placebo-controlled study. Brain Stimul. 2018 Nov - Dec;11(6):1251-1262. doi:

10.1016/j.brs.2018.07.046. Epub 2018 Jul 18. PubMed PMID: 30056141.

543. Ruetten H, Gebauer M, Raymond RH, Calle RA, Cobelli C, Ghosh A, Robertson RP, Shankar SS, Staten MA,

Stefanovski D, Vella A, Wright K, Fryburg DA; Foundation for the NIH Biomarkers Consortium Beta Cell

Project Team. Mixed Meal and Intravenous L-Arginine Tests Both Stimulate Incretin Release Across Glucose

Tolerance in Man: Lack of Correlation with β Cell Function. Metab Syndr Relat Disord. 2018 Oct;16(8):406-

415. doi: 10.1089/met.2018.0022. Epub 2018 Aug 17. Erratum in: Metab Syndr Relat Disord. 2019

Mar;17(2):128. PubMed PMID: 30117761; PubMed Central PMCID: PMC6167614.

544. Brede S, Fehr S, Dalla-Man C, Cobelli C, Lehnert H, Hallschmid M, Klement J. Intranasal oxytocin fails to

acutely improve glucose metabolism in obese men. Diabetes Obes Metab. 2019 Feb;21(2):424-428. doi:

10.1111/dom.13527. Epub 2018 Oct 3. PubMed PMID: 30203536.

545. Visentin R, Schiavon M, Giegerich C, Klabunde T, Man CD, Cobelli C. Long-acting Insulin in Diabetes

Therapy: In Silico Clinical Trials with the UVA/Padova Type 1 Diabetes Simulator(.). Conf Proc IEEE Eng Med

Biol Soc. 2018 Jul;2018:4905-4908. doi: 10.1109/EMBC.2018.8513234. PubMed PMID: 30441443.

546. Shah M, Laurenti MC, Dalla Man C, Ma J, Cobelli C, Rizza RA, Vella A. Contribution of endogenous glucagon-

like peptide-1 to changes in glucose metabolism and islet function in people with type 2 diabetes four weeks

after Roux-en-Y gastric bypass (RYGB). Metabolism. 2019 Apr;93:10-17. doi: 10.1016/j.metabol.2018.12.005.

Epub 2018 Dec 23. PubMed PMID: 30586575; PubMed Central PMCID: PMC6401231.

547. Adams JD, Treiber G, Hurtado MD, Laurenti MC, Dalla Man C, Cobelli C, Rizza RA, Vella A. Increased Rates

of Meal Absorption Do Not Explain Elevated 1-Hour Glucose in Subjects With Normal Glucose Tolerance. J

Endocr Soc. 2018 Nov 21;3(1):135-145. doi: 10.1210/js.2018-00222. eCollection 2019 Jan 1. Erratum in: J

Endocr Soc. 2019 Jan 11;3(3):516. PubMed PMID: 30591957; PubMed Central PMCID: PMC6302905.

548. Anderson SM, Dassau E, Raghinaru D, Lum J, Brown SA, Pinsker JE, Church MM, Levy C, Lam D, Kudva YC,

Buckingham B, Forlenza GP, Wadwa RP, Laffel L, Doyle FJ 3rd, DeVries JH, Renard E, Cobelli C, Boscari F,

Del Favero S, Kovatchev BP. The International Diabetes Closed-Loop Study: Testing Artificial Pancreas

Component Interoperability. Diabetes Technol Ther. 2019 Feb;21(2):73-80. doi: 10.1089/dia.2018.0308. Epub

2019 Jan 16. PubMed PMID: 30649925; PubMed Central PMCID: PMC6354594.

549. Visentin R, Schiavon M, Giegerich C, Klabunde T, Dalla Man C, Cobelli C. Incorporating Long-Acting Insulin

Glargine into the UVA/ Padova Type 1 Diabetes Simulator for In Silico Testing of MDI Therapies. IEEE Trans

Biomed Eng. 2019 Feb 6. doi: 10.1109/TBME.2019.2897851. [Epub ahead of print] PubMed PMID: 30735983.

550. Laurenti MC, Vella A, Varghese RT, Andrews JC, Sharma A, Kittah NE, Rizza RA, Matveyenko A, De Nicolao

G, Cobelli C, Dalla Man C. Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide

concentrations by nonparametric stochastic deconvolution. Am J Physiol Endocrinol Metab. 2019 May

1;316(5):E687-E694. doi: 10.1152/ajpendo.00519.2018. Epub 2019 Feb 26. PubMed PMID: 30807214; PubMed

Central PMCID: PMC6580177.

551. Galderisi A, Zammataro L, Losiouk E, Lanzola G, Kraemer K, Facchinetti A, Galeazzo B, Favero V, Baraldi E,

Cobelli C, Trevisanuto D, Steil GM. Continuous Glucose Monitoring Linked to an Artificial Intelligence Risk

Index: Early Footprints of Intraventricular Hemorrhage in Preterm Neonates. Diabetes Technol Ther. 2019

Mar;21(3):146-153. doi: 10.1089/dia.2018.0383. PubMed PMID: 30835533.

552. Smushkin G, Sathananthan A, Man CD, Camilleri M, Cobelli C, Rizza RA, Vella A. Letter to the Editor:

"Defects in GLP-1 Response to an Oral Challenge Do Not Play a Significant Role in the Pathogenesis of

Prediabetes". J Clin Endocrinol Metab. 2019 Nov 1;104(11):5106-5107. doi: 10.1210/jc.2019-00904. PubMed

PMID: 31074786.

553. Schiavon M, Visentin R, Giegerich C, Klabunde T, Cobelli C, Dalla Man C. Modeling Subcutaneous Absorption

of Long-Acting Insulin Glargine in Type 1 Diabetes. IEEE Trans Biomed Eng. 2020 Feb;67(2):624-631. doi:

10.1109/TBME.2019.2919250. Epub 2019 May 28. PubMed PMID: 31150327.

554. Battelino T, Danne T, Bergenstal RM, Amiel SA, Beck R, Biester T, Bosi E, Buckingham BA, Cefalu WT,

Close KL, Cobelli C, Dassau E, DeVries JH, Donaghue KC, Dovc K, Doyle FJ 3rd, Garg S, Grunberger G,

Heller S, Heinemann L, Hirsch IB, Hovorka R, Jia W, Kordonouri O, Kovatchev B, Kowalski A, Laffel L,

Levine B, Mayorov A, Mathieu C, Murphy HR, Nimri R, Nørgaard K, Parkin CG, Renard E, Rodbard D, Saboo

B, Schatz D, Stoner K, Urakami T, Weinzimer SA, Phillip M. Clinical Targets for Continuous Glucose

Monitoring Data Interpretation: Recommendations From the International Consensus on Time in Range.

Diabetes Care. 2019 Aug;42(8):1593-1603. doi: 10.2337/dci19-0028. Epub 2019 Jun 8. Review. PubMed PMID:

31177185; PubMed Central PMCID: PMC6973648.

555. Basu R, Schiavon M, Petterson XM, Hinshaw L, Slama M, Carter R, Man CD, Cobelli C, Basu A. A novel

natural tracer method to measure complex carbohydrate metabolism. Am J Physiol Endocrinol Metab. 2019 Sep

1;317(3):E483-E493. doi: 10.1152/ajpendo.00133.2019. Epub 2019 Jul 2. PubMed PMID: 31265327; PubMed

Central PMCID: PMC6766609.

556. Bynoe K, Unwin N, Taylor C, Murphy MM, Bartholomew L, Greenidge A, Abed M, Jeyaseelan S, Cobelli C,

Dalla Man C, Taylor R. Inducing remission of Type 2 diabetes in the Caribbean: findings from a mixed methods

feasibility study of a low-calorie liquid diet-based intervention in Barbados. Diabet Med. 2019 Jul 31. doi:

10.1111/dme.14096. [Epub ahead of print] PubMed PMID: 31365159.

557. Fico G, Hernanzez L, Cancela J, Dagliati A, Sacchi L, Martinez-Millana A, Posada J, Manero L, Verdú J,

Facchinetti A, Ottaviano M, Zarkogianni K, Nikita K, Groop L, Gabriel-Sanchez R, Chiovato L, Traver V,

Merino-Torres JF, Cobelli C, Bellazzi R, Arredondo MT. What do healthcare professionals need to turn risk

models for type 2 diabetes into usable computerized clinical decision support systems? Lessons learned from the

MOSAIC project. BMC Med Inform Decis Mak. 2019 Aug 16;19(1):163. doi: 10.1186/s12911-019-0887-8.

PubMed PMID: 31419982; PubMed Central PMCID: PMC6697904.

558. Brown SA, Kovatchev BP, Raghinaru D, Lum JW, Buckingham BA, Kudva YC, Laffel LM, Levy CJ, Pinsker

JE, Wadwa RP, Dassau E, Doyle FJ 3rd, Anderson SM, Church MM, Dadlani V, Ekhlaspour L, Forlenza GP,

Isganaitis E, Lam DW, Kollman C, Beck RW; iDCL Trial Research Group. Six-Month Randomized, Multicenter

Trial of Closed-Loop Control in Type 1 Diabetes. N Engl J Med. 2019 Oct 31;381(18):1707-1717. doi:

10.1056/NEJMoa1907863. Epub 2019 Oct 16. PubMed PMID: 31618560.

559. Toffanin C, Aiello EM, Cobelli C, Magni L. Hypoglycemia Prevention via Personalized Glucose-Insulin Models

Identified in Free-Living Conditions. J Diabetes Sci Technol. 2019 Nov;13(6):1008-1016. doi:

10.1177/1932296819880864. Epub 2019 Oct 23. PubMed PMID: 31645119; PubMed Central PMCID:

PMC6835187.

560. Toffanin C, Kozak M, Sumnik Z, Cobelli C, Petruzelkova L. In Silico Trials of an Open-Source Android-Based

Artificial Pancreas: A New Paradigm to Test Safety and Efficacy of Do-It-Yourself Systems. Diabetes Technol

Ther. 2020 Feb;22(2):112-120. doi: 10.1089/dia.2019.0375. Epub 2019 Dec 17. PubMed PMID: 31769699.

561. Visentin R, Schiavon M, Göbel B, Riz M, Cobelli C, Klabunde T, Dalla Man C. Dual glucagon-like peptide-1

receptor/glucagon receptor agonist SAR425899 improves beta-cell function in type 2 diabetes. Diabetes Obes

Metab. 2019 Dec 5. doi: 10.1111/dom.13939. [Epub ahead of print] PubMed PMID: 31808298.

562. Galderisi A, Tricò D, Dalla Man C, Santoro N, Pierpont B, Groop L, Cobelli C, Caprio S. Metabolic and

Genetic Determinants of Glucose Shape After Oral Challenge in Obese Youths: A Longitudinal Study. J Clin

Endocrinol Metab. 2020 Feb 1;105(2). pii: dgz207. doi: 10.1210/clinem/dgz207. PubMed PMID: 31972003;

PubMed Central PMCID: PMC6977541.

563. Adams JD, Dalla Man C, Laurenti MC, Andrade MDH, Cobelli C, Rizza RA, Bailey KR, Vella A. Fasting

glucagon concentrations are associated with longitudinal decline of β-cell function in non-diabetic humans.

Metabolism. 2020 Feb 8;105:154175. doi: 10.1016/j.metabol.2020.154175. [Epub ahead of print] PubMed

PMID: 32045582.

564. Schiavon M, Visentin R, Giegerich C, Sieber J, Dalla Man C, Cobelli C, Klabunde T. IN SILICO HEAD-TO-

HEAD COMPARISON OF INSULIN GLARGINE 300 U/ML AND INSULIN DEGLUDEC 100 U/ML IN

TYPE 1 DIABETES. Diabetes Technol Ther. 2020 Mar 3. doi: 10.1089/dia.2020.0027. [Epub ahead of print]

PubMed PMID: 32125178.

565. Visentin R, Schiavon M, Göbel B, Riz M, Cobelli C, Klabunde T, Dalla Man C. Dual glucagon-like peptide-1

receptor/glucagon receptor agonist SAR425899 improves beta-cell function in type 2 diabetes. Diabetes Obes

Metab. 2020 Apr;22(4):640-647. doi: 10.1111/dom.13939. Epub 2019 Dec 22. PubMed PMID:31808298.

BOOKS

1. Albergoni V., Cobelli C., Francini G.: Biological Systems. An Engineering Approach to Physiology. Pitagora

Editrice, Bologna, 1974, pgg. 118.

2. Cobelli C., Bergman R.N., eds.: Carbohydrate Metabolism. Quantitative Physiology and Matematical Modelling.

Wiley, Chichester, 1981, pgg. 440.

3. Carson E.R., Cobelli C., Finkelstein L.: The Mathematical Modeling of Endocrine-Metabolic Systems. Model

Formulation, Identification and Validation. Wiley, New York, 1983, pgg. 394.

4. Cobelli C., Mariani L., eds.: Modeling and Control in Biomedical Systems. Pergamon Press, Oxford, 1990, pgg.

665.

5. Cobelli C., Bonadonna R., eds.: Bioingegneria dei Sistemi Metabolici. Pàtron, Bologna, 1998, pgg. 445.

6. Cobelli C., Foster D., Toffolo G.: Tracer Kinetics in Biomedical Research: From Data to Model. Kluwer

Academic/Plenum, London, 2001.

7. Cobelli C, Carson, E: Introduzione alla Modellistica in Fisiologia e Medicina. Patron Editore, Bologna, 2013.

8. Carson E., Cobelli C.: Modelling Methodology for Physiology and Medicine., 2nd Ed, Elesevier, Oxford, 2014,

pgg.564.

9. Cobelli C., Carson E.: Introduction to Modelling in Physiology and Medicine. 2nd edition, Academic Press, San

Diego, 2019, pgg 350.

PATENTS

. 1. PCT/IB2009/051870 (2009).Method and device for processing glycemia level data by means of self-adaptive

filtering, predicting the future glycemia level and generating alerts. Sparacino G., Facchinetti A., Cobelli C. 2. PCT/IB2010/054947 (2010). Method to Recalibrate Continuous Glucose Monitoring Data On-Line. Facchinetti

A., Guerra S., Sparacino G., De Nicolao G., Cobelli C. 3. PCT/US2008/082063 (2010). Predictive control based system and method for control of insulin delivery in diabetes

using glucose sensing. Magni L., De Nicolao G.,.Raimondo D.M, Cobelli C., Dalla Man C. 4. US 13/661,393 (2012). Alert System for Hypo and Hyperglycemia Prevention based on Clinical Risk. Guerra S.,

Facchinetti A., Sparacino G.,Schiavon M., Cobelli C. 5. US 61/606,549 (2012). Method to Improve Safety Monitoring in Type-1 Diabetic Patients by Detecting in Real-

Time Failures of the Glucose Sensor-Insulin Pump System. Facchinetti A., Del Favero S., Sparacino G., Cobelli C. 6. US 61/720,286 (2012). Systems and methods for providing sensitive and specific alarms. Kamath A., Rack-

Gomer A.L., Bhavaraju N, Hampapuram H., Facchinetti A., Zecchin C., Sparacino G., Cobelli C. 7. PCT/US10/40097(2012). System, Method and Computer Simulation Environment For In Silico Trials in Pre-

Diabetes and Type 2 Diabetes. Kovatchev B.P., Cobelli C., Dalla Man C.

8. PCT/US13/661,755 (2012). Estimation of insulin sensitivity from CGM and subcutaneous insulin delivery in type 1

diabetes. Dalla Man C., Schiavon M., Basu A., Kudva Y., Cobelli C.

9.PCT/IB2014/059121 (2013). Retrospective retrofitting method to generate a continuous glucose concentration

profile by exploiting continuous glucose monitoring sensor data and blood glucose. Del Favero S., Facchinetti A.,

Sparacino G., Cobelli C.

10. PCT/IT2012/000083 (2017). Method for controlling the delivery of insulin and the related system. Soru P., Magni

L.,Toffanin C., De Nicolao G., Dalla Man C. , Cobelli C.