Upload
others
View
2
Download
0
Embed Size (px)
Citation preview
Institute of Industrial Science
SAKAI LAB.[Tissue Engineering for Regenerative Medicine
and Cell-Based Assay]Center for International Research on Integrative Biomedical Systems
http://envchem.iis.u-tokyo.ac.jp/sakai/index.php
Organs and Biosystems Engineering
Reconstruction and Utilization of TissuesToward applications to regenerative medicine for transplantation treatment andcell-based assays for drug and chemical screening, we have studied massproduction and differentiation control of progenitor stem cells, construction ofimplantable tissues, and development of cell-based assays.
TISSUE ENGINEERING
CIRIBiSMPUTC
Fe-505
Department ofChemical System EngineeringBioengineering
O2-
O2+
Monolayer
Multilayer
Cell sheet
Liver cell aggregates
Pancreatic islet cellaggregates
5 cm
Top viewSide view
Lung cells
Cell-Based Assays
Construction of 3D cell sheets under direct oxygenation
Development of the large artificial livercombined with 3D printing technology
Building blocks-based tissues for construction of large organs
Enhancement of liver metabolic capacityunder direct oxygenation
and application to drug screening testsConstruction of pancreatic islet models
for diabetes treatments
Development of lung cell-based assay systemsfor nanotoxicology
Biodegradable polymer
Immobilization of liver cells
Biodegradable polymer
Mass Production and Differentiation Control of Progenitor Stem Cells
Implantable Tissues
Mass production of iPS cells using microgel particles
Microgel particles (MGP)
iPS cells in MGP
Differentiation control of iPS cells to hepatocyte-like cells
iPS cells Hepatocyte-like cellsHepatocyte-like cells
O2- O2+
High metabolic capacityLow metabolic capacity
Side view Top view