General Chemistry 2019

Recent Trend

in Organic Chemistry

Organic Chem.

Synthetic Org. Physical Org.

Total Synthesis Methodology

Bioorganic

Organometallic

Material/

Polymer

Computational Supramolecular

Medicinal Catalysis

Organic Chemistry Faculty @ KAIST?

Contemporary Organic Chemistry?

Representative Nobel Laureates

who opens the fields in organic and polymer chemistry.

Whom do you know?

Polymerization of Commodity Chemicals

"for their

discoveries in the

field of the

chemistry and

technology of high

polymers“ (1963)

K. Ziegler G. Natta

CO2-Incorporated Polymers

O

CO O +Cat *OO

O nR R

<A Breakthrough in Polymer Technology>

•Low Petroleum-Dependency: 44 or 50 w%-CO2

•Enzyme Degradable

•Clean Burning

•Adhere to Cellulosic Substrates.

•Form to Tough, Printable Films

•Long Term Mechanical Stability

Total Synthesis & Natural Product Synthesis

"for his outstanding

achievements in the art of

organic synthesis“ (1965)

RB Woodward

Vitamin B12Reserpine

Erythromycin

In his Cope Lecture, Woodward said it best when he acknowledged the special

challenge of chemistry compared to mathematics:

“While in mathematics, presumably one's imagination may run riot without

limit, in chemistry, one's ideas, however beautiful, logical, elegant,

imaginative they may be in their own right, are simply without value unless

they are actually applicable to the one physical environment we have- in

short, they are only good if they work! I personally very much enjoy the very

special challenge which this physical restraint on fantasy presents.”

“In chemistry, ideas have to answer to reality”

Revolutionary Method for Molecular Synthesis

"for the development of the

metathesis method in

organic synthesis“ (in 2005)

Y. Chauvin R.H. Grubbs R.R. Schrock

C=C Formation by Olefin Metathesis

C=C Formation by Olefin Metathesis

Catalytic Bond Formation: C-C & C-X Bonds

R.F. Heck E. Negishi A. Suzuki

“for palladium-catalyzed

cross couplings in organic

synthesis” (in 2010)

Molecular Machines Designed by Chemists

J.-P. Sauvage J. F. Stoddart B. L. Ferringa

“for the design and

synthesis of

molecular machines”

(in 2016)

We can't solve problems by using the same kind of thinkingwe used, when we created them (A. Einstein)

1. ENERGY

2. WATER

3. FOOD

4. ENVIRONMENT

5. POVERTY

6. DISEASE

7. EDUCATION

8. TERRORISM & WAR

9. DEMOCRACY

10. POPULATION 2003 6.5 Billion

People

2050 8-10 Billion People

Humanity’s Top 10 Problems for Future

(by Prof. Richard Smalley, 1996 Nobel Laureate in Chemistry)

Solicitation number DE-RP02-05CH11231 Use or disclosure of data contained on this sheet is subject to the restriction on the title page of this proposal

Nature has a way to convert sunlight, CO2,

water and nutrients into chemical energy

We?

Catalysis in Your Daily Life!

C-H Functionalization & Biomass Conversion

Value-added

Products

Hydrocarbons Biomass

Little functionality Much functionality

Functionality

Uti

lity

Va

lue

Functionalization De-functionalization

CatalysisReactivity &

Selectivity

Methanol

Silylformate

Urea

Carbonate

Capturing CO2 from

exhaust gas…

…to perform

chemical reactions

Pd

Ru

Rh

CO2 is safe and abundant

C1 feedstock to produce

value-added chemicals!!

CO2 Conversion