Recent advances in the monitoring and management of diabetic ketoacidosis

by T.M. Wallace, and D.R. Matthews

QJMVolume 97(12):773-780

November 29, 2004

QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

(a) Increased lipolysis results in the production of acetylCoA from fatty acids which acts as the substrate for hepatic synthesis of ketone bodies (acetoacetate, beta-hydroxybutyrate and

acetone).

T.M. Wallace, and D.R. Matthews QJM 2004;97:773-780

QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

Glucose and β-OHB profiles in two patients admitted with DKA. There is an initial reduction in β-OHB and glucose with treatment.

T.M. Wallace, and D.R. Matthews QJM 2004;97:773-780

QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

The time course for blood glucose (squares), β-hydroxybutyrate (β-OHB, diamonds) and bicarbonate (triangles) in hours from initiation of treatment.

T.M. Wallace, and D.R. Matthews QJM 2004;97:773-780

QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.

Guidelines for the use of the ketone meter in out-patients.

T.M. Wallace, and D.R. Matthews QJM 2004;97:773-780

QJM vol. 97 no. 12 © Association of Physicians 2004; all rights reserved.