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Re-engineering Collaborative Mechanisms and Knowledge Networks to Accelerate
Innovation for Alzheimer’s
Richard A. Johnson Chairman, OECD/BIAC Science & Technology Committee
National Academy of Sciences Board on Life Sciences
CEO, Global Helix LLC
Unlocking Global Collaboration to Accelerate Innovation for Alzheimer’s
Oxford, 20-21 June 2013
Drivers of Key Inflection Points for AD Research, Accelerated Innovation, & Care Models Require Policy Shifts
• Re-engineering Clinical Research
Ecosystem
• Convergence and the “New Biology”
• Next-generation “Enabling Tools Revolution and Platforms”
• Aligning Science and Biomedicine
with “Challenge-driven Innovation” and the “Knowledge Triangle” : Problem-driven, Tool-based, and Solutions-oriented
• Big Data and Knowledge Networks
and Markets • Patient-centered Approaches from the
Outset
• Global Solutions & Local Knowledge
Re-Engineering the Clinical Research Ecosystem (10 years on) (Grady 2004)
Convergence of the “New Biology” with Physical Sciences & Engineering + Redrawing the Boundaries for Accelerating Research and Translation =
Foundational Shift for AD and Biomedicine over next 20 years
The “New Biology” (NAS, 2009/2011) The “Third Revolution” in Life Sciences (MIT 2011)
New Enabling Tools and Platforms Required to Traverse the Scales (and Complexity) of the Brain – not to mention
Innovative Care Models (Donoghue, Brown Institute for Brain Science, 2013)
Aligning AD Research and National AD Strategies with National Innovation Strategies and new Business Models: New AD Initiatives Build
on Open Innovation, Multi-directional S&T, University-Industry Partnering, Pre-competitive Consortia, Forward-looking IPR, and New Public-Private Collaborative
Mechanisms to Enable Cutting-edge Research, Innovation, and Care Models
Challenge-driven Innovation: AD Research as a Foundation for The Creative Destruction of Medicine [in a good way] and Innovative Care Models
Eric Topol (2012) Patient-driven needs require innovative research beyond traditional research paradigms
• Expand the Research Agenda
– Social Science research matters – Risk Reduction strategies – Understanding support communities – Behavioral and lifestyle research
• Non-technological innovation matters: Risk reduction strategies, Best practices for Innovative Care, Innovation Models of support services
Big Data Changes (Almost) Everything -- The Fourth Paradigm (Gray 2009), the Internet of Things/M2M, Big Data Analytics,
and Patient-centered Data Come Together in New AD Research, Collaborative Mechanisms, Patient Choice Options, and Healthcare Initiatives
Big Data: New Sets of Access, Diffusion, Ownership, and Re-Use Policy Issues
Range of Inter-related Issues
The eMERGE Network = DNA biorepositories + Electronic Medical Records + GWAS studies + Results in Clinical Care Settings
• Data Silos
• Governance
• Curation, management, and quality
• Privacy and confidentiality
• Data linkages
• Lack of standards, interoperability, data exchanges, common nomenclature
• Patient consent and research re-use
• Data, samples, and material transfers
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Rapid Growth of Knowledge Networks and Markets
OECD Knowledge Networks and Markets (2012)
Patient-centered from the Outset: Re-coupling Research and Technology with Patients, Families, and Support Communities
Banner Alzheimer’s Institute/NIA Experiment
Reintegrating Technology Innovation, Social Needs, and Patients (Maynard 2013)
AD is a Global Crisis: Addressing the Growing Burden in Low- and Middle-Income Countries
10/66 Dementia Research Group: more than 2/3 of dementia patients but < 10% of the population-based funding
But New Global Opportunities to Leverage Global Solutions & Local Knowledge/Contexts
G8 Dementia Summit AD Innovation, Financial Infrastructure, Portfolio Theory, and Global Securitization (Andrew Lo, MIT - 2013)
Research Collaborations Broaden and Deepen
Global Business Becomes a Major Player and Partner
Comprehensive Regional Initiatives – e.g., Europe
Patient-driven Strategies and Venture Philanthropy
1. Maximize OECD’s Role as the “Gold standard” Think Tank and Economic Bridge to Economics/Finance/Budget Ministries
The Reality of Alzheimer’s: Fiscal Nightmare and Barrier to Sustainable Economic Growth: If Dementia Were a Country, It Would be the World’s 18th Largest Economy
Developing the Economic Case for Investing in AD and the Need for a Global Financing Mechanism Cumulative Costs of AD ~ € 460 billion; >1% of global GDP (and rising)
2. Create an OECD Global Policy Forum on National/Regional/Subnational Plans – leverage the OECD’s convening
power on a global scale by creating a global policy hub
13 National Plans +
Complement Core Building Blocks such as JPND (Europe/Canada) and NAPA (U.S.)
• Best Practices, Infrastructure, Governance and Accountability
• Whole-of-government Policies (beyond Research only)
• Financing Mechanisms
• Multi-stakeholder Strategies
• Comprehensive Collaborations
Develop a Global “Network of Networks” to Enable Comprehensive Collaboration and Policy Coherence
Leverage extensive OECD expertise on new Innovation Modes, Knowledge Networks, Business Models, and Virtual Organizations
• Scaling for optimal impact
• Compression of time scales/cycle times (“Silicon Valley time” rather than academic/government ministry time cycles)
• Optimization
• Prioritization
• Impact assessments and metrics
Combined with OECD-facilitated Global Databases
• International Database of Shared Research Infrastructures for AD
• Network of Global AD Database Linkages
• Database of International R&D Collaborations in AD
3. Focus on Innovating Regulatory Governance and Regulatory Science: an OECD “Berlin 2.0” Process
4. Develop Financing Toolkits and Mechanisms to Leverage Public-Private Funding, to Attract Risk Capital, and to “De-Risk” Research & Innovative
Care Models
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5. AD and Big Data Technical Roadmap: Standards, Validation, Measurement, Interoperability, Data Transfer Protocols
Why a Standards-driven Roadmap? Proven Approach in other Complex, Cumulative, Integrated Domains
• Standardized Information Commons
• Global-scale patient registries
• Facilitating trans-border data flows and database linkage technical policy issues
• Best practices for pre-competitive data sharing, access & diffusion
Biomarkers as a Case Study building on OECD 2010-2012 work programs and analysis
6. Strategic Design, Business Models, Globalization, and Measurement of PPPs and Collaborative Mechanisms
• Program design and metrics
• Governance structures
• Interoperability and collaboration
• Financing Modes
• Strategic Policy Mix for PPPs
• Globalization of PPPs
Compelling OECD Value Proposition: Delivering Global Best Practices and Innovative, Whole-of-Government Policies in Support of AD
Research, Innovative Care Models, and Public Awareness
Thank You!
“Knowing is not enough; we must apply.
Willing is not enough; we must do.”
—Goethe
Contact Email: [email protected]