12
P.O. Box 586 Needham, MA 02494 Phone: 1-800/535-6734 Fax: 1-781/433-0767 www.ramsci.com Correlation Study for SAFE-T-FILL ® Plastic Blood Gas Capillary Tubes vs. Glass Blood Gas Capillary Tubes Complete Data Glass tubes: 100μL borosilicate glass, Lithium Heparin, Allegiance brand Note 1: The samples used for testing were first drawn into BD Vacutainer™ Plus PST Lithium Heparin tubes, Plastic tubes: 150μL balanced heparin from RAM Scientific, part number 06 0186 from which each of the blood gas capillary tubes cor correlation were then filled and analyzed. Analyzer: Roche Omni Note 2: samples 15-19 were exposed to air for 30 minutes pH pCO 2 pO 2 HCO 3 SO 2 Na Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic 01 6.8850 6.8990 01 145.80 140.10 01 7.60 9.10 01 27.00 26.80 01 2.70 3.60 01 109.80 111.00 02 7.3650 7.3670 02 42.20 43.20 02 65.90 67.40 02 23.60 24.20 02 91.80 92.30 02 138.30 139.50 03 7.0950 7.1120 03 70.60 65.80 03 35.90 37.90 03 21.20 20.50 03 44.30 49.10 03 137.60 139.20 04 6.9130 6.9320 04 110.40 104.70 04 17.20 16.50 04 21.80 21.60 04 9.20 9.00 04 107.10 109.30 05 7.2430 7.2470 05 62.90 63.00 05 16.20 17.00 05 26.50 26.90 05 15.90 17.40 05 139.20 137.20 06 7.3570 7.3580 06 45.40 44.40 06 41.70 42.50 06 24.90 24.40 06 74.40 75.60 06 137.30 141.50 07 7.3310 7.3370 07 49.10 46.40 07 89.00 95.80 07 25.30 24.30 07 96.00 96.80 07 140.10 142.70 08 7.3610 7.3630 08 44.30 43.60 08 57.00 58.50 08 24.50 24.20 08 87.90 88.80 08 128.70 130.70 09 7.3480 7.3490 09 47.70 47.40 09 97.20 101.60 09 25.60 25.50 09 97.10 97.40 09 138.20 139.90 10 7.3210 7.3270 10 49.50 47.60 10 68.10 69.00 10 25.00 24.40 10 91.40 91.80 10 142.20 139.20 11 7.3800 7.3790 11 42.10 40.70 11 41.40 42.70 11 24.30 23.50 11 75.40 77.00 11 140.50 141.50 12 7.4440 7.4050 12 32.90 37.60 12 47.70 47.50 12 22.00 23.00 12 84.90 83.10 12 141.80 142.40 13 6.8890 6.8900 13 126.30 126.20 13 24.00 24.70 13 23.60 23.60 13 15.10 15.90 13 140.70 142.00 14 7.0240 7.0260 14 95.80 95.60 14 26.20 26.00 14 24.40 24.40 14 23.00 22.90 14 136.30 137.40 15 7.3310 7.3330 15 46.30 44.50 15 43.80 44.30 15 24.00 23.10 15 75.50 76.00 15 139.10 141.00 16 6.9830 6.9980 16 93.10 94.40 16 59.30 62.00 16 21.60 22.10 16 69.00 72.10 16 100.60 106.70 17 7.3180 7.3280 17 49.20 47.10 17 41.90 43.10 17 24.70 24.20 17 72.10 74.40 17 140.60 139.60 18 6.9580 6.9770 18 92.40 85.60 18 28.00 28.50 18 20.20 19.60 18 22.20 23.80 18 110.30 111.00 19 7.3210 7.3510 19 43.50 40.60 19 82.60 101.70 19 22.00 22.00 19 94.80 97.40 19 135.90 137.40 K Cl tHb O 2 Hb CO 2 Hb Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic 01 01 97.50 98.90 01 10.50 10.50 01 5.30 4.90 01 2.00 1.20 02 3.900 3.890 02 98.20 102.40 02 17.00 16.70 02 85.40 87.10 02 7.70 8.20 03 10.450 10.260 03 98.10 103.10 03 16.70 16.50 03 77.90 80.70 03 3.30 2.50 04 04 99.20 102.30 04 9.90 9.90 04 21.20 20.60 04 2.10 2.10 05 3.940 3.690 05 99.00 105.60 05 14.40 14.40 05 23.60 23.70 05 0.60 0.60 06 3.950 4.210 06 104.10 102.60 06 14.40 15.00 06 73.40 73.80 06 1.60 1.40 07 3.260 3.340 07 98.10 101.10 07 12.20 12.40 07 91.10 91.80 07 5.00 5.00 08 4.280 4.290 08 93.90 99.30 08 14.50 14.20 08 87.30 87.70 08 2.40 2.50 09 3.150 3.290 09 101.20 101.00 09 13.30 13.80 09 94.20 94.60 09 2.80 2.40 10 3.190 3.040 10 97.00 104.10 10 16.00 16.40 10 90.70 90.60 10 2.10 2.30 11 4.000 4.030 11 93.70 95.60 11 13.90 13.80 11 75.60 75.60 11 1.60 1.70 12 3.610 3.600 12 100.30 102.00 12 10.80 10.80 12 82.00 82.40 12 2.00 1.90 13 11.390 11.340 13 93.50 98.40 13 13.90 13.80 13 41.50 41.40 13 3.90 3.70 14 9.690 9.470 14 97.30 98.90 14 15.90 15.90 14 51.80 53.30 14 3.10 3.10 15 3.990 3.940 15 102.40 106.60 15 10.80 13.50 15 72.40 73.20 15 1.30 1.80 16 16 99.40 103.30 16 14.90 16 85.90 16 5.40 17 3.910 3.730 17 99.60 105.40 17 13.00 13.20 17 71.40 74.80 17 1.50 1.60 18 18 98.20 100.70 18 15.90 15.70 18 56.00 56.60 18 3.80 7.20 19 3.730 3.760 19 97.60 99.80 19 0.00 19 19 RAM_blood_gas_study.xls!data tables PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

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Page 1: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone: 1-800/535-6734 Fax: 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL® Plastic Blood Gas Capillary Tubesvs. Glass Blood Gas Capillary Tubes

Complete DataGlass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Note 1: The samples used for testing were first drawn into BD Vacutainer™ Plus PST Lithium Heparin tubes,

Plastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 from which each of the blood gas capillary tubes cor correlation were then filled and analyzed.Analyzer: Roche Omni Note 2: samples 15-19 were exposed to air for 30 minutes

pH pCO2 pO2 HCO3 SO2 Na

Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic01 6.8850 6.8990 01 145.80 140.10 01 7.60 9.10 01 27.00 26.80 01 2.70 3.60 01 109.80 111.0002 7.3650 7.3670 02 42.20 43.20 02 65.90 67.40 02 23.60 24.20 02 91.80 92.30 02 138.30 139.5003 7.0950 7.1120 03 70.60 65.80 03 35.90 37.90 03 21.20 20.50 03 44.30 49.10 03 137.60 139.2004 6.9130 6.9320 04 110.40 104.70 04 17.20 16.50 04 21.80 21.60 04 9.20 9.00 04 107.10 109.3005 7.2430 7.2470 05 62.90 63.00 05 16.20 17.00 05 26.50 26.90 05 15.90 17.40 05 139.20 137.2006 7.3570 7.3580 06 45.40 44.40 06 41.70 42.50 06 24.90 24.40 06 74.40 75.60 06 137.30 141.5007 7.3310 7.3370 07 49.10 46.40 07 89.00 95.80 07 25.30 24.30 07 96.00 96.80 07 140.10 142.7008 7.3610 7.3630 08 44.30 43.60 08 57.00 58.50 08 24.50 24.20 08 87.90 88.80 08 128.70 130.7009 7.3480 7.3490 09 47.70 47.40 09 97.20 101.60 09 25.60 25.50 09 97.10 97.40 09 138.20 139.9010 7.3210 7.3270 10 49.50 47.60 10 68.10 69.00 10 25.00 24.40 10 91.40 91.80 10 142.20 139.2011 7.3800 7.3790 11 42.10 40.70 11 41.40 42.70 11 24.30 23.50 11 75.40 77.00 11 140.50 141.5012 7.4440 7.4050 12 32.90 37.60 12 47.70 47.50 12 22.00 23.00 12 84.90 83.10 12 141.80 142.4013 6.8890 6.8900 13 126.30 126.20 13 24.00 24.70 13 23.60 23.60 13 15.10 15.90 13 140.70 142.0014 7.0240 7.0260 14 95.80 95.60 14 26.20 26.00 14 24.40 24.40 14 23.00 22.90 14 136.30 137.4015 7.3310 7.3330 15 46.30 44.50 15 43.80 44.30 15 24.00 23.10 15 75.50 76.00 15 139.10 141.0016 6.9830 6.9980 16 93.10 94.40 16 59.30 62.00 16 21.60 22.10 16 69.00 72.10 16 100.60 106.7017 7.3180 7.3280 17 49.20 47.10 17 41.90 43.10 17 24.70 24.20 17 72.10 74.40 17 140.60 139.6018 6.9580 6.9770 18 92.40 85.60 18 28.00 28.50 18 20.20 19.60 18 22.20 23.80 18 110.30 111.0019 7.3210 7.3510 19 43.50 40.60 19 82.60 101.70 19 22.00 22.00 19 94.80 97.40 19 135.90 137.40

K Cl tHb O2Hb CO2Hb

Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic Sample Glass Plastic01 01 97.50 98.90 01 10.50 10.50 01 5.30 4.90 01 2.00 1.2002 3.900 3.890 02 98.20 102.40 02 17.00 16.70 02 85.40 87.10 02 7.70 8.2003 10.450 10.260 03 98.10 103.10 03 16.70 16.50 03 77.90 80.70 03 3.30 2.5004 04 99.20 102.30 04 9.90 9.90 04 21.20 20.60 04 2.10 2.1005 3.940 3.690 05 99.00 105.60 05 14.40 14.40 05 23.60 23.70 05 0.60 0.6006 3.950 4.210 06 104.10 102.60 06 14.40 15.00 06 73.40 73.80 06 1.60 1.4007 3.260 3.340 07 98.10 101.10 07 12.20 12.40 07 91.10 91.80 07 5.00 5.0008 4.280 4.290 08 93.90 99.30 08 14.50 14.20 08 87.30 87.70 08 2.40 2.5009 3.150 3.290 09 101.20 101.00 09 13.30 13.80 09 94.20 94.60 09 2.80 2.4010 3.190 3.040 10 97.00 104.10 10 16.00 16.40 10 90.70 90.60 10 2.10 2.3011 4.000 4.030 11 93.70 95.60 11 13.90 13.80 11 75.60 75.60 11 1.60 1.7012 3.610 3.600 12 100.30 102.00 12 10.80 10.80 12 82.00 82.40 12 2.00 1.9013 11.390 11.340 13 93.50 98.40 13 13.90 13.80 13 41.50 41.40 13 3.90 3.7014 9.690 9.470 14 97.30 98.90 14 15.90 15.90 14 51.80 53.30 14 3.10 3.1015 3.990 3.940 15 102.40 106.60 15 10.80 13.50 15 72.40 73.20 15 1.30 1.8016 16 99.40 103.30 16 14.90 16 85.90 16 5.4017 3.910 3.730 17 99.60 105.40 17 13.00 13.20 17 71.40 74.80 17 1.50 1.6018 18 98.20 100.70 18 15.90 15.70 18 56.00 56.60 18 3.80 7.2019 3.730 3.760 19 97.60 99.80 19 0.00 19 19

RAM_blood_gas_study.xls!data tables PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 2: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubespH Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: pH

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9967126

Result: 0.9636747 0.2644468 Standard Error of Y: 0.0117823Standard: 0.0159766 0.1152523 F Statistic: 3638.2650

Error Degr. of Freedom: 12.0

pH - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 6.89 6.9002 7.37 7.3703 7.10 7.1104 6.91 6.9305 7.24 7.2506 7.36 7.3607 7.33 7.3408 7.36 7.3609 7.35 7.3510 7.32 7.3311 7.38 7.3812 7.44 7.4113 6.89 6.8914 7.02 7.0315 7.33 7.33 samples 15-19 were exposed to air 16 6.98 7.00 for 30 minutes17 7.32 7.3318 6.96 6.9819 7.32 7.35

6.80

6.90

7.00

7.10

7.20

7.30

7.40

7.50

6.80 6.90 7.00 7.10 7.20 7.30 7.40 7.50

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 3: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubespCO2 Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: pCO2

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9954625

Result: 0.9574168 1.5994851 Standard Error of Y: 2.4182706Standard: 0.0186599 1.4394520 F Statistic: 2632.6004

Error Degr. of Freedom: 12.0

pCO2 - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 145.80 140.1002 42.20 43.2003 70.60 65.8004 110.40 104.7005 62.90 63.0006 45.40 44.4007 49.10 46.4008 44.30 43.6009 47.70 47.4010 49.50 47.6011 42.10 40.7012 32.90 37.6013 126.30 126.2014 95.80 95.6015 46.30 44.50 samples 15-19 were exposed to air 16 93.10 94.40 for 30 minutes17 49.20 47.1018 92.40 85.6019 43.50 40.60

0.00

20.00

40.00

60.00

80.00

100.00

120.00

140.00

160.00

0.00 20.00 40.00 60.00 80.00 100.00 120.00 140.00 160.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 4: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubespO2 Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: pO2

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9977504

Result: 1.0510856 -0.8103202 Standard Error of Y: 1.4177328Standard: 0.0144077 0.7554817 F Statistic: 5322.1830

Error Degr. of Freedom: 12.0

pO2 - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 7.60 9.1002 65.90 67.4003 35.90 37.9004 17.20 16.5005 16.20 17.0006 41.70 42.5007 89.00 95.8008 57.00 58.5009 97.20 101.6010 68.10 69.0011 41.40 42.7012 47.70 47.5013 24.00 24.7014 26.20 26.0015 43.80 44.30 samples 15-19 were exposed to air 16 59.30 62.00 for 30 minutes17 41.90 43.1018 28.00 28.5019 82.60 101.70

0.00

20.00

40.00

60.00

80.00

100.00

120.00

0.00 20.00 40.00 60.00 80.00 100.00 120.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 5: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesHCO3 Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: HCO3

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.8972239

Result: 0.9549136 0.9225602 Standard Error of Y: 0.5738515Standard: 0.0932973 2.2689816 F Statistic: 104.7587

Error Degr. of Freedom: 12.0

HCO3 - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 27.00 26.8002 23.60 24.2003 21.20 20.5004 21.80 21.6005 26.50 26.9006 24.90 24.4007 25.30 24.3008 24.50 24.2009 25.60 25.5010 25.00 24.4011 24.30 23.5012 22.00 23.0013 23.60 23.6014 24.40 24.4015 24.00 23.10 samples 15-19 were exposed to air 16 21.60 22.10 for 30 minutes17 24.70 24.2018 20.20 19.6019 22.00 22.00

0.00

5.00

10.00

15.00

20.00

25.00

30.00

0.00 5.00 10.00 15.00 20.00 25.00 30.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 6: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesSO2 Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: SO2

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9985422

Result: 0.9944680 1.1482802 Standard Error of Y: 1.4668917Standard: 0.0109688 0.7453518 F Statistic: 8219.8623

Error Degr. of Freedom: 12.0

SO2 - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 2.70 3.6002 91.80 92.3003 44.30 49.1004 9.20 9.0005 15.90 17.4006 74.40 75.6007 96.00 96.8008 87.90 88.8009 97.10 97.4010 91.40 91.8011 75.40 77.0012 84.90 83.1013 15.10 15.9014 23.00 22.9015 75.50 76.00 samples 15-19 were exposed to air 16 69.00 72.10 for 30 minutes17 72.10 74.4018 22.20 23.8019 94.80 97.40

0.00

20.00

40.00

60.00

80.00

100.00

120.00

0.00 20.00 40.00 60.00 80.00 100.00 120.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 7: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesNa Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: Na

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9757118

Result: 0.9609724 6.3561494 Standard Error of Y: 1.7949432Standard: 0.0437681 5.8901147 F Statistic: 482.0668

Error Degr. of Freedom: 12.0

Na - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 109.80 111.0002 138.30 139.5003 137.60 139.2004 107.10 109.3005 139.20 137.2006 137.30 141.5007 140.10 142.7008 128.70 130.7009 138.20 139.9010 142.20 139.2011 140.50 141.5012 141.80 142.4013 140.70 142.0014 136.30 137.4015 139.10 141.00 samples 15-19 were exposed to air 16 100.60 106.70 for 30 minutes17 140.60 139.6018 110.30 111.0019 135.90 137.40

0.00

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100.00

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140.00

160.00

0.00 20.00 40.00 60.00 80.00 100.00 120.00 140.00 160.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 8: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesK Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: K

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9986046

Result: 0.9830348 0.0528224 Standard Error of Y: 0.1330076Standard: 0.0106078 0.0606224 F Statistic: 8587.9811

Error Degr. of Freedom: 12.0

K - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 0.00 0.0002 3.90 3.8903 10.45 10.2604 0.00 0.0005 3.94 3.6906 3.95 4.2107 3.26 3.3408 4.28 4.2909 3.15 3.2910 3.19 3.0411 4.00 4.0312 3.61 3.6013 11.39 11.3414 9.69 9.4715 3.99 3.94 samples 15-19 were exposed to air 16 0.00 0.00 for 30 minutes17 3.91 3.7318 0.00 0.0019 3.73 3.76

0.00

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4.00

6.00

8.00

10.00

12.00

0.00 2.00 4.00 6.00 8.00 10.00 12.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 9: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesCl Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: Cl

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.3573514

Result: 0.5344752 48.7486463 Standard Error of Y: 2.1943122Standard: 0.2069074 20.2721044 F Statistic: 6.6727

Error Degr. of Freedom: 12.0

Cl - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 97.50 98.9002 98.20 102.4003 98.10 103.1004 99.20 102.3005 99.00 105.6006 104.10 102.6007 98.10 101.1008 93.90 99.3009 101.20 101.0010 97.00 104.1011 93.70 95.6012 100.30 102.0013 93.50 98.4014 97.30 98.9015 102.40 106.60 samples 15-19 were exposed to air 16 99.40 103.30 for 30 minutes17 99.60 105.4018 98.20 100.7019 97.60 99.80

92.00

94.00

96.00

98.00

100.00

102.00

104.00

106.00

108.00

92.00 94.00 96.00 98.00 100.00 102.00 104.00 106.00

GLASS

RA

M P

LAST

IC

ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 10: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubestHb Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: tHb

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9848612

Result: 0.9834420 0.2787367 Standard Error of Y: 0.2881870Standard: 0.0351979 0.4922961 F Statistic: 780.6644

Error Degr. of Freedom: 12.0

tHb - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 10.50 10.5002 17.00 16.7003 16.70 16.5004 9.90 9.9005 14.40 14.4006 14.40 15.0007 12.20 12.4008 14.50 14.2009 13.30 13.8010 16.00 16.4011 13.90 13.8012 10.80 10.8013 13.90 13.8014 15.90 15.9015 10.80 13.50 samples 15-19 were exposed to air 16 0.00 14.90 for 30 minutes17 13.00 13.2018 15.90 15.7019 0.00 0.00

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ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 11: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesO2Hb Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: O2Hb

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9992471

Result: 1.0129002 -0.3159315 Standard Error of Y: 0.8668047Standard: 0.0080262 0.5661141 F Statistic: 15926.2225

Error Degr. of Freedom: 12.0

O2Hb - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 5.30 4.9002 85.40 87.1003 77.90 80.7004 21.20 20.6005 23.60 23.7006 73.40 73.8007 91.10 91.8008 87.30 87.7009 94.20 94.6010 90.70 90.6011 75.60 75.6012 82.00 82.4013 41.50 41.4014 51.80 53.3015 72.40 73.20 samples 15-19 were exposed to air 16 0.00 85.90 for 30 minutes17 71.40 74.8018 56.00 56.6019 0.00 0.00

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0.00 20.00 40.00 60.00 80.00 100.00

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ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004

Page 12: RAM blood gas study

P.O. Box 586Needham, MA 02494

Phone 1-800/535-6734Fax 1-781/433-0767

www.ramsci.com

Correlation Study for SAFE-T-FILL Blood Gas Capillary TubesCO2Hb Analysis

Glass tubes: 100µL borosilicate glass, Lithium Heparin, Allegiance brand Correlation StudyPlastic tubes: 150µL balanced heparin from RAM Scientific, part number 06 0186 Analyte: CO2Hb

Analyzer: Roche Omni Test Date: 2/10/2003Notes: The samples used for testing were first drawn into BD Vacutainer™ Plus

PST Lithium Heparin tubes, from which each of the blood gas capillary Regression Statistics:tubes for correlation were then filled and analyzed. Slope Intercept r Squared: 0.9685313

Result: 1.0643533 -0.2990716 Standard Error of Y: 0.3523195Standard: 0.0553832 0.1848148 F Statistic: 369.3313

Error Degr. of Freedom: 12.0

CO2Hb - Glass to RAM Plastic X axis Y axisSample # Glass Plastic01 2.00 1.2002 7.70 8.2003 3.30 2.5004 2.10 2.1005 0.60 0.6006 1.60 1.4007 5.00 5.0008 2.40 2.5009 2.80 2.4010 2.10 2.3011 1.60 1.7012 2.00 1.9013 3.90 3.7014 3.10 3.1015 1.30 1.80 samples 15-19 were exposed to air 16 0.00 5.40 for 30 minutes17 1.50 1.6018 3.80 7.2019 0.00 0.00

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ResultsPerfect CorrelationRegression

RAM_blood_gas_study.xls!analysis PROPRIETARY TO RAM SCIENTIFIC, INC. printed:1/19/2004