1

Raimund Hirschberg, M.D. Professor of Medicine, UCLA

Investigator, Los Angeles Biomedical Research Institute

Curriculum Vitae & Bibliography1 Address: Business: Division of Nephrology & Hypertension

Box 406, Harbor-UCLA Medical Center 1000 West Carson Street Torrance, CA 90509

Phone: 310-222-3891 FAX: 310-782-1837 E-mail: rhirschberg@labiomed.org

Research: Investigator Los Angeles Biomedical Research Institute (LaBioMed) at Harbor-UCLA Medical Center 1124 West Carson St Torrance, CA 90502

Phone: 310-222-3891 FAX: 310-782-1837 E-mail: rhirschberg@labiomed.org

Honors & Awards Doctorate in Medicine (Dissertation "Magna cum Laude"), Free University of Berlin 1979 Postdoctoral Lecturing Qualification in Internal Medicine, Free University of Berlin School of Medicine 1989 Awarded Specialist in Hypertension, American Society of Hypertension 1999 Blue Ribbon Award for Abstract rated top 10%ile

World Congress of Nephrology, Berlin, Germany 2003 Elected Member, 'Best Doctors in America' 2007-

Societies

German Nephrological Society International Society of Nephrology American Society of Nephrology Kidney Council, American Heart Association American Society of Hypertension American Society for Diagnostic and Interventional Nephrology

1Revised: July 6th, 2015

2 Journal Review Activities

FASEB J J Cell Biochem Journal of Clinical Investigation Journal of Biological Chemistry PLOS One Kidney International Journal of the American Society of Nephrology Diabetes Diabetes/Metabolism Research and Reviews Oncogene Pediatric Nephrology Pediatric Research Developmental Genetics Arthritis & Rheumatism Journal of Laboratory and Clinical Medicine Journal of Parenteral and Enteral Nutrition Endocrinology Journal of Endocrinology Cardiovascular Research American Journal of Nephrology American Journal of Pathology Nephron Internet J Nephrol Medical Science Monitor Nephrology, Dialysis, Transplantation The Journal of Urology/Investigative Urology Journal of the American Medical Association American Journal of Physiology - Renal Physiology Physiology Genetics European Journal of Clinical Investigation Cellular & Molecular Life Sciences Canadian Journal of Physiology & Pharmacology Experimental Biology and Medicine Microvascular Research Kidney & Blood Pressure Research Clinical Journal of the American Society of Nephrology British Journal of Hematology Thomson Reuters Key Opinions Diabetes/Metabolism Research and Reviews Abstract Reviewer, American Society of Nephrology, 1990 Abstract Reviewer, American Society of Nephrology, 1993 Abstract Reviewer, American Society of Nephrology, 1996 Abstract Reviewer, International Society of Nephrology, 1999 Abstract Reviewer, American Society of Nephrology, 2002 Abstract Reviewer, World Congress of Nephrology, 2005

3 Abstract Reviewer, American Society of Nephrology, 2009 Abstract Reviewer, American Society of Nephrology, 2012 Abstract Reviewer, American Society of Nephrology, 2013 Extramural Reviewer, Dept. of Veterans Affairs Research Service, Merit Reviews Extramural Reviewer, Canadian Institute of Health Research, Ottawa, Canada Extramural Reviewer, Dutch Diabetes Research Foundation, Amersfoort, The Netherlands Extramural Reviewer, Research Council of Ireland, Dublin, Ireland Vice Chair, Centers of Excellence Review Section, NIDDK, NIH, 2007 Member, Renal & Urological Sciences B Review Section, NIH, 2008 Extramural Reviewer, Kidney Research UK 2006 - Extramural Reviewer, The Wellcome Trust Extramural Reviewer, Diabetes UK 2011 - Member, Pathobiology of Kidney Disease Study Section, NIDDK, NIH, 2006, 2007, 2009 Member, NIH-R24 Review Section, 2009 Member, NIH-ZRG1DKUS Review Group, January 2010 Member, AHA Peer Review Committee 1A, 2010 Member, NIH-ZRG1DKUS Review Group, May 2010 Member, NIH-ZRG1GRB-S-05 Review Group, May 2011 Member, NIH-ZDK1 GRB-N Review Group October 2011 Ad-hoc Member, NIH-NIDDK PBKD Study Section, February 2012 Vice Chair, NIH-NIDDK Pediatric Nephrology Centers of Excellence Review Section, March

2012

Editorial Boards Editorial Board, International Journal of Nephroloy & Urology 2009 - Editorial Board, Diabetes Review Letters 2009 - Consulting Editor, Cardiovascular Research 2008 - Editorial Board, American Journal of Physiology, Renal Physiology 2001 - Editorial Board, Journal of the American Society of Nephrology 2001 - 2007 Editorial Board, American Journal of Kidney Diseases, 2000 – 2002 Advisory Board, American Journal of Kidney Diseases 2014 - Editorial Board, American Journal of Nephrology 1998 - 2002 Guest Editor, Mineral and Electrolyte Metabolism, 1997

Local Committee Memberships Quality Assurance and Improvement Committee, Department of Medicine, Harbor-UCLA

Medical Center, 1992 - 2015 End-Stage Renal Disease Committee, Harbor-UCLA Medical Center, 1988- Clinical Research Center Advisory Committee, Harbor-UCLA Medical Center, 1990-2000 Animal Care and Use Review Committee, Harbor-UCLA Research and Education Institute,

1994-1997; Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center 2003 –

4 Vice Chair, Animal Care and Use Review Committee, Los Angeles Biomedical Research

Institute at Harbor-UCLA Medical Center 2015 - Human Subjects Committee, Harbor-UCLA Research and Education Institute, 1998-2000 UCLA-Council on Academic Personnel Ad Hoc Review Committee 2003/2004.

Activities in National Organizations Medical Advisory Board, National Kidney Foundation of Southern California, 1988-1994. Research Committee, National Kidney Foundation of Southern California 1990-1993; 1998- Study Section on Grants-In-Aid, National Heart Association, Greater Los Angeles Affiliate

1991 - 1993 Study Section on Fellowship Grants, National Heart Association, Greater Los Angeles

Affiliate, 1992, 1993, 1995 Research Fellowship Selection Committee, National Kidney Foundation, New York, NY,

1994. Young Investigator Grant Committee, National Kidney Foundation, New York, NY, 1994 -

1996 Nephrology Study Section, Veterans Administration Research Service, 1995 Medical Advisory Board Excecutive Committee, National Kidney Foundation of Southern

California, 1995 - 1999 Working Committee on Guidelines for Nutrition in Dialysis, National Kidney Foundation

1996-1997 Councilor, American Society for Diagnostic and Interventional Nephrology, 2001 - 2003 Member, Renal Biopsy Guidelines Committee, American Society for Diagnostic and

Interventional Nephrology, 2009-2010 Member, Certifications Committee/Ultrasonography Subcommittee, American Society for

Diagnostic and Interventional Nephrology, 2001- present

Consultant Non-exclusive Consultant, Chiron Pharmaceuticals, 1994 - 1997 Non-exclusive Consultant, Celtrix Pharmaceuticals, 1996 Non-exclusive Consultant, Novartis Pharmaceuticals, 1999 - Non-exclusive Consultant, Phenomix Corporation 2005 - 2009 Non-exclusive Consultant, Savient Pharmaceuticals Corp 2007 Advisor, INC-Research Corporation 2012 -

Session Chairmanships Co-Chair, Clinical and Experimental Session, Vth International Congress of Nutrition and

Metabolism in Renal Disease, Strassbourg, France 1988. Co-Chair, Poster Discussion Session on Diabetic Nephropathy I, Annual Meeting of the

American Society of Nephrology, Washington, DC, 1990. Co-Chair, Cell Biology Session, VIth International Congress of Nutrition and Metabolism in

Renal Disease, Harrogate, UK 1991. Co-Chair, Session on the Role of Growth Factors in Nephrogenesis and Cellular

Differentiation, Annual Meeting, American Society of Nephrology, Boston, 1993.

5 Chair, Workshop “Renal Ultrasound”, Spring Clinical Meeting, National Kidney

Foundation, Anaheim CA, 1996. Chair, Minisymposium Growth factors in acute renal failure, Annual Meeting, American

Society of Nephrology, New Orleans, 1996. Chair, Workshop Renal Ultrasound, Spring Clinical Meeting, National Kidney

Foundation, San Antonio, TX, 1997 Chair, Basic Science Symposium: Growth Hormone - A mediator of glomerular lesions?

American Society of Nephrology, Annual Meeting, San Antonio, TX, 1997 Chair, Workshop on Renal Ultrasonography, Annual Meeting, American Society of

Nephrology, San Diego, 2003. Co-Chair, Session on Renal Fibrosis: Start and Stop. Annual Meeting, American Society of

Nephrology, Philadelphia, PA, 2011 Co-Chair, Session on Renal Fibrogenesis, Annual Meeting, American Society of

Nephrology, San Diego, CA, 2012 Co-Chair, Session on Renal Fibrosis, Annual Meeting, American Society of Nephrology,

Atlanta, GA, 2013

Invited Lectures (Excerpt) "Effects of growth hormone and IGF-I on renal function in man" Fourth International Congress on Nutrition and Metabolism in Renal Disease, Williamsburg, VA, 1985. "Growth hormone and IGF-I modulate renal function" Fifth International Congress on Nutrition and Metabolism in Renal Disease, Strasbourg, France, 1988. "Energy Requirements in patients with chronic renal failure" International Symposium on Nutrition in Renal Disease, Chiety, Italy, 1989. "IGF-I and the kidney" Second International Conference on Insulin-like Growth Factors, San Francisco, CA. 1991. "The growth hormone-IGF-I axis and glomerular function" Sixth International Congress on Nutrition and Metabolism in Renal Disease, Herrogate, UK, 1991. "Insulin-like growth factor I" Grand Rounds, Department of Medicine, University of Gottingen, Gottingen, Germany, 1992. "IGF-I and the Kidney" Fourth International Symposium on Insulin and Insulin-like Growth Factors, Woods Hole, MA, 1993. �Insulin-like Growth Factors and the Kidney�, Medical Grand Rounds, University of Erlangen-Nürnberg, Erlangen, Germany, 1993. "Importance of Nutritional Status and Outcomes in Acute Renal Failure", A Computer-Interactive Session, Third Spring Clinical Meeting, National Kidney Foundation, Washington, DC, 1995. "IGF-I and IGFBPs in the Nephrotic Syndrome", International Symposium on Growth and Endrocrine Changes in Kidney Diseases, International Pediatric Nephrology Association, Heidelberg, Germany, 1995. "IGF-I and the Kidney", The Endocrine Meetings, Washington, DC, 1995.

6 Percutaneous Renal Biopsy, Spring Clinical Meeting, National Kidney Foundation, Anaheim, April 1996. Effects of Growth Hormone on Renal Hemodynamics, American Physiological Society, FASEB Meeting, Washington DC, April 1996. Effects of growth hormone and IGF-I on renal hemodynamics, 3rd Internet World Congress on Biomedical Sciences, The Virtual Conference Hall, http://www.3iwc.riken.go.jp, December 1996 (�300,000 hits). Does IGF-I improve renal function in acute and chronic renal failure?, Annual Meeting, European Renal Association, Geneva, September 1997. Introduction: Growth Hormone - A mediator of glomerular lesions?, Basic Science Symposium, Annual Meeting, American Society of Nephrology, San Antonio, TX, 1997. Glomerular Ultrafiltration of Growth Factors in the Nephrotic Syndrome, 9th Int Congr Nutr Metab Ren Dis, Vienna, Austria, 1998. Glomerular Ultrafiltration of Growth Factors in the Nephrotic Syndrome, Nephrology Grand Rounds, University of California, Davis, November 1998. Newer Pharmacologic Therapies in Acute Renal Failure, Spring Clinical Meeting, National Kidney Foundation, Washington DC, 1999. Epithelial Injury and Repair: Role of Growth Factors, 14th Scientific Congress, International Society of Nephrology, Buenos Aires, Argentina, 1999. Proteinuria-Induced Renal Injury, Free University of Berlin, School of Medicine, Berlin, Germany, 1999. Proteinuria and Progression of Chronic Renal Failure, Invited Plenar Lecture, Annual Scientific Meeting, German Society of Nephrology, Vienna, September 2000 “Does BMP7 oppose renal fibrogenicity?” Symposium Lecture, Annual Scientific Meeting, American Society of Nephrology, Philadelphia, PA, 2002 “Growth Factors and Matrix”, Invited Lecture, Annual Scientific Meeting, American Society of Nephrology, Philadelphia, PA, 2002 “Proteines and Proteinuria”, Invited Lecture, Symposium ‘Nutrition and Nephrology: Theory and Practice’, Lyon, France, 2003. "Renal Fibrogenesis in Diabetic Nephropathy", Grand Rounds Lecture, Department of Endocrinology and Diabetes, City of Hope National Medical Center, Duarte, CA, 2005. "Growth factors in renal interstitial fibrogenesis", Invited Lecture, World Congress of Nephrology, Singapore, 2005.

7 "Wound Healing in the Kidney", Invited Lecture, Annual Scientific Meeting, American Society of Nephrology, San Diego, CA, 2006 "BMP7 in Diabetic Nephropathy", Grand Rounds Lecture, Department of Endocrinology and Diabetes, City of Hope National Medical Center, Duarte, CA, 2006 "Wound Healing and the Kidney", Medical Grand Rounds, Harbor-UCLA Medical Center, Torrance, CA, March 2007. "BMP7 in Diabetic Nephropathy", Nephrology Grand Rounds, Harbor-UCLA Medical Center, Torrance, CA, September 2007 "Diabetic Nephropathy, parsing the phenotype: Tubulo-interstitial compartment", Invited Lecture, Annual Scientific Meeting, American Society of Nephrology, San Francisco, CA, November 2007. Visiting Professor, Departments of Pathology and Nephrology, Northwestern University; Research Lecture "BMP7 in Diabetic Nephropathy" given. Chicago, IL, March 2009. "Bartter's Syndromes", Clinical Lecture Series, Division of Endocrinology, Harbor-UCLA Medical Center, Torrance, CA, July 2009. "Renal Tubular Acidosis", Nephrology Grand Rounds, USC Medical Center, Los Angeles, CA, March 2010. “Renal Artery Stenosis: A Medical Perspective”, Nephrology Grand Rounds, USC Medical Center, Los Angeles, CA, January 2011. "Targeting non-canonical TGFβ pathways", Invited Lecture, Annual Scientific Meeting, American Society of Nephrology, Denver, CO, November 2010. “Management of the Hypertensive Patient”, Division of HIV-Medicine Grand Rounds, Harbor-UCLA Medical Center, March 2011. “Renal Artery Stenosis Revisited”, Nephrology Grand Rounds, Cedars-Sinai Medical Center, Los Angeles, CA April 2011. “Management of Hypertensive Patients”, Grand Rounds, Long Beach Comprehensive Care Center, Long Beach, CA April 2011. “Of Cilia & Cysts: Biology and Clinics of adPCKD”, Medicine Grand Rounds, Harbor-UCLA Medical Center, Torrance, CA, December 2011.

Research Grants Deutsche Forschungsgemeinschaft: Research Fellowship Award, 1985-1987. Research and Education Institute, Harbor-UCLA Medical Center; PI: Raimund Hirschberg, M.D. Equipment Grant, 1989.

8 Research and Education Institute, Harbor-UCLA Medical Center; PI: Raimund Hirschberg, M.D. "Response of insulin-like growth factor I and renal hemodynamics to a high and low protein diet in the rat", 12/88-12/89. National Kidney Foundation of Southern California, PI: Raimund Hirschberg, M.D. "Importance of Insulin-like growth factor I in regulating nephron dynamics", 10/89-10/90. Harbor Collegium, PI: Raimund Hirschberg, M.D. "Relationship of glomerular hypertrophy, nephron dynamics and glomerular sclerosis in a rat model", 6/90-6/91. Ciba Geigy Corporation; PI: Raimund Hirschberg, M.D. "Effect of Insulin-like growth factor I on renal function in normal man". 4/90-4/91. American Heart Association; PI: Raimund Hirschberg, M.D. "Effects of Growth hormone and IGF-I on the glomerulus", 7/90-6/94. NIH/NIDDK: PI: Joel D. Kopple, M.D., Co-PI: Sharon Adler, M.D., Raimund Hirschberg, M.D. "The Modification of Diet in Renal Disease (MDRD)"; Project Period: 9/84 - 9/93. University of Southern California (Subcontract NIH DK45426): PI: Joel D. Kopple, M.D., Co-PI: Raimund Hirschberg, M.D. "Kidney Disease and Hypertension in Blacks"; Project Period: 8/94 - 7/95. Harbor-UCLA Research and Education Institute: PI: Raimund Hirschberg, M.D. "IGF-I in in-vitro tubule cell injury"; Project Period: 11/94 - 10/95. Harbor-UCLA Research and Education Institute: PI: Sharon Adler, M.D., Co-PI: Raimund Hirschberg, M.D. "RNA Banks in Kidney Disease"; Project Period: 11/94 - 11/97. Chiron Corporation: PI: Joel D. Kopple, M.D., CO-PI: Raimund Hirschberg, M.D. "Trial of recombinant human insulin-like growth factor I in patients with acute renal failure.� Project Period: 2/95 - 1/97. Hoechst-Marion-Roussell: PI: Sharon Adler, M.D., Co-PI: Raimund Hirschberg, M.D. �Aminoguanidine in the treatment of type 2 diabetic nephropathy�. Project Period: 9/95 - 8/99. American Diabetes Association: PI: Sharon Adler, M.D., Co-PI: Raimund Hirschberg, M.D. �The pathogenesis of diabetic nephropathy. Project Period: 1/96 - 1/98. Juvenile Diabetes Foundation International: PI: Raimund Hirschberg, M.D. �Importance of ultrafiltered insulin-like growth factor I in diabetic nephropathy�. Project Period 9/96 - 8/98. Juvenile Diabetes Foundation International; PI: Raimund Hirschberg, M.D. �Glomerular ultrafiltration of HGF in diabetic nephropathy�. Project Period 9/98 - 06/01. Juvenile Diabetes Research Foundation (JDRF 1-2004-78); Protection of Podocytes from Diabetic Injury; PI: Raimund Hirschberg; 4/2004 to 3/2007. NIH-NIDDK (DK 063360), Prevention of Diabetic Nephropathy by BMP7. PI: Raimund

9 Hirschberg, 7/2004 to 7/2008.

10

Raimund Hirschberg, MD

Bibliography

Original, Peer-Reviewed, Scientific Publications 1) Riedel W, R Hirschberg, A Kaul, H Schmier, U Walter. Comparative investigations of the

biokinetics of Thorium, Circonium and Hafnium dioxides in animals. Environm Res 18 (1979), 127-139.

2) Hirschberg R, K Schaefer, D von Herrath, G Kreutz, H Kewitz. Digoxin-quinidine interaction in patients with renal failure. Klin Wochenschr 59 (1981), 521-522.

3) Hirschberg R, K Schaefer. Syndrom des Toxischen Schocks. Pathogenese, Diagnose, Therapie. Dtsch Med Wochenschr 108 (1983), 912-917.

4) Hirschberg R, D von Herrath, A Pauls, K Schaefer. No rise in glomerular filtration rate after protein load in severe liver disease. Lancet II, 1984, 1047-1048 (Letter).

5) Hirschberg R, D von Herrath, H Klaus, W Hoefer, C Schuster, H Rottka, K Schaefer. Effect of diets containing varying concentrations of essential fatty acids and triglycerides on renal function in uremic rats and NZB/NZW F1 mice. Nephron 38 (1984), 233-237.

6) Hirschberg R, D von Herrath, K Voss, W Bosaller, U Mauelshagen, A Pauls, K Schaefer. Parathyroid hormone and 1,25-dihydroxivitamin D3 affect the tissue concentration of zink in uremic rats. Nephron 39 (1985), 277-279.

7) Hirschberg R, D von Herrath, K Voss, W Bosaller, U Mauelshagen, A Pauls, K Schaefer. Organ distribution of aluminum in uremic rats: Influence of parathyroid hormone and 1,25-dihydroxivitamin D3. Mineral Electrolyte Metab 11 (1985), 106-110.

8) Hirschberg R, D von Herrath, H Rottka, A Pauls, K Schaefer. Effect of an acute protein load on the creatinine clearance in healthy vegetarians. Klin Wochenschr 63 (1985), 217-220.

9) Hirschberg R, W Hoefer, K Schaefer. Endotoxin-induced acute renal failure in mice. Effects of indomethacin and the thromboxane-synthetase antagonist UK 38.485. Res Exp Med 185 (1985), 107-113.

10) Saupe J, R Hirschberg, W Hoefer, W Bosaller, D von Herrath, A Pauls, K Schaefer. Effect of long-term administration of 1,25-dihydroxivitamin D3 and 1-alpha-hydroxivitamin D3 on the calcium content of the aorta, heart, and kidney of normal and uremic rats. Nephron 43 (1986), 290-292.

11) von Herrath D, J Saupe, R Hirschberg, H Rottka, K Schaefer: Glomerular filtration rate in response to an acute protein load. Blood Purif 6 (1988), 264-268.

12) Hirschberg R, JD Kopple. Role of growth hormone in the amino acid induced acute rise in renal function in man. Kidney Int. 32 (1987), 382-387.

13) Daskolopolous G, M Pinzani, N Murray, R Hirschberg, RD Zipser. Effects of captopril on renal function in patients with cirrhosis and ascites. J Hepatol 4 (1987), 330-336.

15) Hirschberg R, JD Kopple. Effects of ketoacid supplements on renal function and histology in azotemic rats fed high protein diets. Am J Nephrol 8 (1988), 50-56

16) Hirschberg R, R Zipser, LA Slomowitz, JD Kopple. Glucagon and prostaglandins are mediators of the amino acid induced rise in renal hemodynamics in man. Kidney Int. 33 (1988), 1147-1155.

17) Hirschberg R, JD Kopple. Increase in renal plasma flow and GFR during growth

11 hormone treatment may be mediated by insulin - like growth factor I. Am J Nephrol 8 (1988), 249-253.

18) Slomowitz LA, R Hirschberg, JD Kopple. Captopril augments the renal response to an amino acid infusion in diabetic adults. Am J physiol 255 (Renal Fluid Electrolyte Physiol. 24) (1988), F755-F762.

19) Hirschberg R, JD Kopple. Evidence that Insulin-like growth factor I increases renal plasma flow and GFR in fasted rats. J Clin Invest 83 (1989), 326-330

20) Hirschberg R, H Rabb, R Bergamo, JD Kopple. The delayed effect of growth hormone on renal function in man. Kidney Int. 35 (1989), 865-870.

21) Erley C, R Hirschberg, W Hoefer, K Schaefer: Acute renal failure due to uric acid nephropathy in a patient with renal hypouricemia. Klin Wochenschr 67 (1989), 308-312.

22) Lemmi C, Pelikan P, Sikka S, Hirschberg R, Geesaman B, Miller R, Park K, Liu S, Koyle M, Rajfer J: Cyclosporine augments renal mitochondrial function in vivo and reduces renal blood flow. Am J Physiol 257 (Renal Fluid Electrolyte Physiol. 26): F837-F841, 1989.

23) Golper TA, M Wolfson, S Ahmad, R Hirschberg, P Kurtin, LA Katz, R Nicora, D Ashbrook, JD Kopple: Multicenter Trial of L-carnitine in maintenance hemodialysis patients. I. Carnitine concentrations and lipid effects. Kidney Int. 38 (1990), 904-911.

24) Ahmad S, HT Robertson, TA Golper, M Wolfson, P Kurtin, LA Katz, R Hirschberg, R Nicora, DW Ashbrook, JD Kopple: Multicenter trial of L-carnitine in maintenance hemodialysis patients. II. Clinical and biochemical effects. Kidney Int. 38 (1990), 912-918.

25) Hirschberg R, Kopple J, Blantz R, Tucker B: Effects of recombinant human insulin-like growth factor I on glomerular dynamics in the rat. J Clin Invest 87 (1991), 1200-1206.

26) Hirschberg R, Kopple J: Response of insulin-like growth factor I and renal hemodynamics to a high and low protein diet in the rat. J Am Soc Nephrol 1 (1991), 1034-1040.

27) Hirschberg R, Kopple J: The growth hromone - IGF-I axis and renal glomerular function. J Am Soc Nephrol 2 (1992), 1417-1422.

28) Hirschberg R, Brunori G, Kopple J, Guler H: The effects of insulin-like growth factor I on renal function in man. Kidney Int 43 (1993), 387-397.

29) Ding H, Kopple J, Cohen A, Hirschberg R: Recombinant human insulin-like growth factor I accelerates recovery and reduces catabolism in rats with ischemic acute renal failure. J Clin Invest 91 (1993), 2281-2287.

30) Hirschberg R: Effects of Growth Hormone and IGF-I on glomerular ultrafiltration in growth hormone deficienct rats. Regulat Peptides 48 (1993), 241-250.

31) Hirschberg R, Ding H, Wanner C: Effects of insulin-like growth factor I on phosphate transport in cultured proximal tubule cells. J Lab Clin Med 125 (1995), 428-434.

32) Nast C, Hirschberg R, Artishevsky A, Adler S: Misoprostol partially inhibits the renal scarring of chronic cyclosporine nephrotoxicity. Am J Therapeut 2 (1995), 882-885

33) Feld S, Hirschberg R, Artishevsky A, Nast C, Adler S: Insulin-like growth factor I induces mesangial proliferation and increases mRNA and secretion of collagen. Kidney Int 48 (1995), 45-51.

34) Hirschberg R, Kaysen G: Insulin-like growth factor-I and its binding proteins in the experimental nephrotic syndrome. Endocrinology 136 (1995), 1565-1571.

35) Kopple J, Ding H, Hirschberg R: Effects of recombinant human insulin-like growth factor I on renal handling of phosphorus, calcium, and sodium in normal humans. Am J Kidney Dis 26 (1995), 818-824.

36) Slomowitz L, Bergam R, Hirschberg R, Grosvenor M, Kopple J: Enalapril attenuates the renal hemodynamic effects of acetazolamide in patients with diabetes mellitus: Possible

12 implications for tubuloglomerular feedback. Am J Nephrol 16 (1996), 315-319.

37) Ding H, Gao X, Hirschberg R, Vadgama J, Kopple J: Effects of insulin-like growthfactor I on protein synthesis and degradation in skeletal muscle of rats with chronic renal failure: Evidence for a postreceptor defect. J Clin Invest 97 (1996), 1064-1075.

38) Feld S, Hirschberg R: IGF-I and IGF-binding proteins in the nephrotic syndrome. Pediatr Nephrol 10 (1996), 355-358.

39) Hirschberg R: Bioactivity of glomerular ultrafiltrate during heavy proteinuria may contribute to renal tubulo-interstitial lesions: Evidence for a role of insulin-like growth factor I. J Clin Invest 98 (1996), 116-124.

40) Bohe J, Ding H, Quing D, Yoon K, Hirschberg R, Kopple J: IGF-Binding Proteins, IGF-Binding Protein mRNA and IGF-I Receptor mRNA in Rats with Acute Renal Failure given IGF-I. Kidney Int 54 (1998), 1070-1082

41) Hirschberg R, Ding H: Mechanisms of IGF-I-incuded accelerated recovery in experimental ischemic acute renal failure. Mineral Electrolyte Metab 24 (1998), 211-219.

42) Feld S, Figueroa P, Savin V, Nast C, Sharma R, Sharma M, Hirschberg R, Adler S: Plasmapheresis in the treatment of steroid-resistant focal and segmental glomerulosclerosis. Am J Kidney Dis 32 (1998), 230-237.

43) Hirschberg R, Kopple J, Lipsett P, Benjamin E, Minei J, Albertson T, Munger M, Metzler M, Zaloga G, Murray M, Lowry S, Conger J, McKeown W, O’Shea M, Baughman R, Wood K, Haupt M, Kaiser R, Simms H, Warnock D, Summer W, Hintz R, Myers B, Haenftling K, Capra W, Pike M, Guler H: Multicenter Clinical Trial of recombinant human insulin-like growth factor I in patients with acute renal failure. Kidney Int 55 (1999), 2423-2432.

44) Wang S, LaPage J, Hirschberg R: Glomerular ultrafiltration and apical tubular action of IGF-I, TGF-β and HGF in the nephrotic syndrome. Kidney Int 56(1999), 1247-1251.

45) Wang S, LaPage J, Hirschberg R: Glomerular ultrafiltration of IGF-I may contribute to increased renal sodium retention in diabetic nephropathy. J Lab Clin Med 134 (1999), 154-160.

46) Wang S, LaPage J, Hirschberg R: Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy. Kidney Int 57 (2000), 1002-1014.

47) Wang S, LaPage J, Hirschberg R: Growth factor ultrafiltration in glomerular proteinuria causes tubular cell transformation. Am J Physiol 278 (2000), F554-F560.

48) Wang S, DeNichilo M, Brubaker C, Hirschberg R: Connective tissue growth factor in tubulo-interstitial injury of diabetic nephropathy. Kidney Int 60 (2001), 96-105.

49) Wang S, LaPage J, Hirschberg R: Loss of bone morphogenetic protein-7 in diabetic nephropathy. J Am Soc Nephrol 12:2392-2399, 2001.

50) Wang S, Hirschberg R: BMP7 antagonizes TGF-beta – dependent fibrogenesis in mesangial cells. Am J Physiol Renal Physiol 284:F1006-F1013, 2003.

51) Wang S, Hirschberg R: BMP7 signals opposing TGFβ in mesangial cells. J Biol Chem 279:23200-23206, 2004.

52) Wang S, Wilkes M, Leof E, Hirschberg R: Imatinib mesylate blocks a non-smad TGFβ pathway and reduces renal fibrogenesis in-vivo. FASEB J 19: 1-11. 2005.

53) Wang S, de Caestecker M, Kopp J, Mitu G, LaPage J, Hirschberg R: Renal bone morphogenetic protein-7 protects against diabetic nephropathy. J Am Soc Nephrol 17:2504-2512, 2006.

54) Mitu G, Wang S, Hirschberg R: BMP7 is an autocrine podocyte survival factor and rescues podocytes from diabetic injury. Am J Physiol Renal Physiol 293:F1641-F1648, 2007.

55) Hirschberg R, Bennett W, Scheinman J, Coppo R, Ponticelli C: Acute kidney injury due to

13 deferoxamine in a renal transplant patient. Nephrol Dial Transplant.23:2704-2705, 2008.

56) Hirschberg R, Wang S, Mitu G: Functional Symbiosis between Endothelium and Epithelial Cells in Glomeruli. Cell Tissue Res 331:485-493, 2008.

57) Wang S, Mitu G, Hirschberg R: Osmotic polyuria: An overlooked mechanism in diabetic nephropathy. Nephrol Dial Transpl 23:2167-2172, 2008.

58) Wang S, Hirschberg R: Diabetes-relevant regulation of cultured blood outgrowth endothelial cells. Microvasc Res 78:174-179, 2009.

59) Eastell R, Black DM, Boonen S, Adami S, Felsenberg D, Lippuner K, Cummings SR, Delmas PD, Palermo L, Mesenbrink P, Cauley J; HORIZON Pivotal Fracture Trial. 266 Collaborators (incl Hirschberg R): Effect of once-yearly zoledronic acid five milligrams on fracture risk and change in femoral neck bone mineral density. J Clin Endocrinol Metab 94:3215-3225, 2009.

60) Kalantar-Zadeh K, Gutekunst L, Mehrotra R, Koves D , Ross R, Shinaberger C, Noori N, Hirschberg R, Brenner D, Nissenson R, Kopple J: Understanding sources of dietary phosphate in the treatment of patients with chronic kidney disease. Clin J Am Soc Nephrol 5:519-530, 2010.

61) Wang S, Wilkes MC, Leof EB, Hirschberg R: Non-canonical TGFβ-pathways, mTORC1 and Abl, in Renal interstitial fibrogenesis. Am J Physiol-Renal Physiol 298:F142-F149, 2010.

63) Patel-Chamberlin M, Wang Y, Satrapoj B, Phillips L, Nast C, Dai T, Watkins R, Wu X, Natarajan R, Leng A, Ulanday K, Hirschberg R, LaPage J, Nam E, Haq Tahmina, Adler S: Hematopoietic growth factor inducible neurokinin-1 (HGFIN, aka GPNMB/Osteoactivin): A biomarker of renal injury across species. Kidney Int. 79:1138-1148, 2011.

62) Wang S, Hirschberg R: Y-box protein-1 is a transcriptional regulator of BMP7. J Cell Biochem. 112:1130-1137, 2011.

63) Yevzlin A, Abreo K, Charles O’Neill, Maya I, Hirschberg R: ASDIN Position Paper: Recommendations and Guidelines for the Performance and Training in Temporary Central Vein Catheters for Hemodialysis. Sem Dial. In Press.

64) Piga A, Fracchia S, Lai M, Cappellini M, Hirschberg R, Habr D, Wegener A, Bouillaud E, Forni G: Deferasirox effect on renal hemodynamic parameters in patients with transfusion dependent β thalassemia. Br J Haematol 168:882-890, 2015

Proceedings, Editorials, Letters 1) Hirschberg R, JD Kopple. Effects of growth hormone on GFR and renal blood flow in

man. Kidney Int 32, Suppl. 22, (1987), S21-S24. 2) Hirschberg R, JD Kopple: Effects of growth hormone and IGF-I on renal function. Kidney

Int. 36, Suppl. 27 (1989),S20-S26. 3) Kopple J, G Brunori, M Leiserowitz, C Mattimore, R Hirschberg. Growth hormone

treatment for patients with renal failure. Proceedings, XIth Int Congr Nephrol, Tokya, Japan, 1990.

4) Hirschberg R, JD Kopple. Energy requirements in patients with chronic renal failure. Contrib Nephrol 81 (1990), 124-135.

5) Hirschberg R, HP Guler, JD Kopple. The effects of insulin-like growth factor I on renal hemodynamics. In: E. Martin Spencer (Editor), Modern Concepts of Insulin-like Growth Factors. Elsevier, New York, 1991.

6) Kopple J, G Brunori, M Leiserowitz, C Mattimore, R Hirschberg: Growth hormone treatment for patients with renal failure. In: M. Hatano (Editor), Nephrology Proceedings

14 of the Xith International Congress of Nephrology, Vol 1, Springer Verlag, Tokyo, 1991, pp379-388.

7) Hirschberg R, JD Kopple: The growth hormone - IGF-I axis and glomerular function. Proceedings, 6th Int Congr Nutr Metabol Renal Dis.

8) Hirschberg R: The physiology and pathophysiology of IGF-I in the kidney. In: D. LeRoith & M. Raizada (Edits.): Current Directions in Insulin-like Growth Factor Research (Advances in Experimental Medicine and Biology, Vol 343), Plenum Publishing Corporation, New York, 1993, pp. 345-366.

9) Hirschberg R: Insulin-like growth factor I in the kidney. Proceedings, 7th International Conference on Renal Nutrition and Metabolism, Stockholm, Sweden, May/June 1994. Miner Electrolyte Metab 22: 129-132, 1995.

10) Maroni B, Hirschberg R: The importance of nutritional status and outcomes from acute renal failure. Proceedings, 4th Annual Spring Clinical Nephrology Meeting, National Kidney Foundation, Inc., New York, NY 10016.

11) Ding H, Hirschberg R: The effects of growth hormone and IGF-I on renal hemodynamics. Clin Exp Physiol Pharmacol. In Press.

12) Hirschberg R: The effects of growth hormone and IGF-I on renal hemodynamics, 3rd Internet Congress on Biomedical Sciences, CD-ROM, Fujitsu Co. Ltd, Japan, June 1997.

13) Wang S, LaPage J, Hirschberg R: Glomerular ultrafiltration and apical tubular action of IGF-I, TGF-β and HGF in the nephrotic syndrome. Forefronts in Nephrology. Kidney Int 56:1247-1251, 1999.

14) Wang S, LaPage J, Hirschberg R: Pathophysiologic Glomerulo-Tubular Growth Factor Link. Proceedings, 9th Int Congr Nutr Metab Ren Dis, Vienna, 1998, Miner Electrolyte Metab. 25:1999:234-241.

15) Wang S, LaPage J, Hirschberg R: Role of glomerular ultrafiltration of growth factors in progressive interstitial fibrosis in diabetic nephropathy. Kidney Int 57 (2000), 1002-1014.

16) Hirschberg R: Proteins and Proteinuria. Proceedings, Symposium ‘Nutrition and Nephrology: Theory & Practice’, XXIV Symposium Gambro, Lyon, France, 2003.

17) Hirschberg R: Nephrotoxicity of third-generation, intravenous bisphosphonates. Toxicology 196:165-167, 2004.

18) Berenson J, Hirschberg R: Safety and convenience of a 15-minute infusion of zoledronic acit. Oncologist 9:319-329, 2004.

19) Berenson J, Hirschberg R: Reply letter: Safety and convenience of a 15-minute infusion of zoledronic acid. Oncologist 10: 84-87, 2005.

20) Hirschberg R: What Benjamin Babington, William Osler, Frederick Weber, and Henri Rendu did not know. Cardiovasc Res 68:180-182, 2005.

21) Hirschberg R, Bennett W, Scheinman J, Coppo R, Ponticelli C: Acute kidney injury due to deferoxamine in a renal transplant patient. Letter. Nephrol Dial Transplant 23:2704-2705, 2008.

22) Hirschberg R: The third vasculature gets attention. Cardiovasc Res. 80:324-325, 2008. 23) Hirschberg R: Glomerular hyperfiltration in sickle cell disease. Clin J Am Soc Nephrol 5:

748-749, 2010. 24) Hirschberg R: Kindlin-2: A new player in renal fibrogenesis. J Am Soc Nephrol 24:1339-

1340, 2013

15 Invited Manuscripts 1) Saupe J, R Hirschberg, D von Herrath, K Schaefer: Long-term application of 1,25-

dihydroxyvitamin D3. Effect on its serum level in dialysis patients and on the calcium content of various organs in experimental uremia. Contrib Nephrol 65 (1988), 115-122.

2) Kopple J, R Hirschberg: Physiological effects of growth hormone and insulin-like growth factor I on the kidney. Miner Electrolyte Metab 16 (1990), 82-88.

3) Kopple JD, Brunori G, Leiserowitz M, Mattimore C, Hirschberg R: Growth hormone treatment for patients with renal failure. Nippon Jinzo Gakkai Shi 33 (1991), 468-474.

4) Hirschberg R: IGF-I accelerates the recovery from experimental acute renal failure. Editorial, Nutrition 9 (1993), 562-563.

5) Hirschberg R: IGF-I and the Kidney. Editorial, J Lab Clin Med 122 (1993), 636-638. 6) Hirschberg R, Kopple J: IGF-I and Renal Function. Diabetes Rev 3 (1995), 177-195. 7) Maroni B, Hirschberg R: Nutritional status and outcome from acute renal failure.

Contemp Dial Nephrol 17 (1996), 22-25. 8) Feld S, Hirschberg R: Insulinlike growth factor I and the Kidney. Trends Endocrinol

Metab 7 (1996), 85-93. 9) Feld S, Hirschberg R: Growth Hormone, the IGF-System and the Kidney. Endocr Rev 17

(1996), 423-480 10) Ding H, Hirschberg R: Effects of growth hormone and IGF-I on renal hemodynamics.

Clin Exp Physiol Pharmacol. In Press. 11) Hirschberg R, Maroni B: Protein and energy metabolism in acute renal failure. Sem Dial

10: 74-81, 1997. 12) Wang S, Hirschberg R: Role of growth factors in acute renal failure. Nephrol Dial

Transplant 12 (1997), 1560-1563. 13) Hirschberg R: Biologically active peptides in acute renal failure: recent clinical trials.

Nephrol Dial Transplant. 12 (1997), 1563-1566. 14) Hirschberg R, Ding H: Growth factors and acute renal failure. Sem Nephrol 18 (1998),

191-207. 15) Hirschberg R: An Oscar for TGF-β and its performance in the kidney. Min Electrolyte

Metab 24: 1-7-110, 1998. 16) Hirschberg R, Adler S: The insulin-like growth factor system and the kidney: Physiology,

pathophysiolocy, and therapeutic implications. Am J Kidney Dis 31:1-20, 1998. 17) Hirschberg R, Adler S: The insulin-like growth factor system and the kidney: Physiology,

pathophysiolocy, and therapeutic implications. Am J Kidney Dis 31:1-34, 1998, only online at http://www.ajkdjournal.org (extended version with additional material).

18) Hirschberg R: Rekombinante Wachstumsfaktoren: Neue therapeutische Perspektiven beim Akuten Nierenversagen. Intensivmedizin 35:680-690, 1998.

19) Wang S, Hirschberg R: Tubular epithelial cell activation and interstitial fibrosis in the nephrotic syndrome - what is the role of glomerular ultrafiltration of growth factors? Editorial Comment, Nephrol Dial Transplant 14:2072-2074, 1999.

20) Pham K, Hirschberg R: Global safety of coxibs and NSAIDs. Curr Top Med Chem 5: 465-473, 2005.

21) Hirschberg R: Protein Ultrafiltration and interstitial fibrogenesis. Curr Opin Nephrol Hypertens 14:43-52, 2005.

22) Hirschberg R: Wound healing in the kidney: Complex interactions in renal interstitial fibrogenesis. J Am Soc Nephrol 16: 9-11, 2005.

23) Mitu G, Hirschberg R: BMP7 in Chronic Kidney Disease. Front Biosci 13:4726-4739, 2008.

24) Hirschberg R: Renal complications from bisphosphonate treatment. Curr Opin Supp Palliat Care 6:342-347, 2012.

16

Book Chapters 1) Hirschberg R, JD Kopple. Requirements for protein, calories and fat in the pre-dialysis

patient. In: S Klahr and W Mitch (Edit.): Nutrition and the kidney. Little, Brown and Company, Boston, 1988, pp. 131-153.

2) Hirschberg R, JD Kopple. Enteral Nutrition and Renal Disease. In: Rombeau J, Caldwell M (Edits): Clinical Nutrition, Volume 1, Enteral and Tube Feeding, Second Edition, W.B. Saunders Comp, Boston, 1990, pp. 400-415.

3) Hirschberg R, JD Kopple. Nutritional therapy in patients with renal failure. In: D.Z. Levine (Edit.): Care for the renal Patient. W.B. Saunders Company, Boston, 1991, pp. 169-180.

4) Hirschberg R: The Effects of growth hormone and insulin-like growth factor I on renal glomerular and tubular function. In: Flyvbjerg A, Orskov H, Alberti FK (Edit): Growth hormone and insulin-like growth factor I in human and experimental diabetes: Basic and clinical aspects. John Wiley & Sons, Ltd, Chichester, England, UK, 1993

5) Kopple J, Hirschberg R: Nutrition for the peritoneal dialysis patient. In: S. Klahr and W. Mitch (Edits): Nutrition and the Kidney. 2. Edition, Little Brown and Company, Boston, 1993.

6) Hirschberg R, Kopple J: Ernährung bei chronischer Hämodialyse. In: H. Franz and W. Hörl (Edits): Blutreinigungsverfahren, 5th Edition, Georg Thieme Publishers, Stuttgart, Germany, 1997, pp. 116-123.

8) Hirschberg R, Kopple J: Ernährung bei chronischer ambulanter Peritonealdialyse. In: H. Franz and W. Hörl (Edits): Blutreinigungsverfahren, 5th Edition, Georg Thieme Publishers, Stuttgart, Germany, 1997, pp.446-452.

9) Hirschberg R: Drug-Nutrient Interactions in Renal Failure. In: J. Kopple & S. Massry (Edits): Nutritional Management of Renal Disease, Williams & Wilkins, Baltimore, MD. 1996. PP 799-815.

10) Hirschberg R: Growth hormone and insulin-like growth factor I in acute and chronic renal failure. In: Rose B: UpToDate in Nephrology, UpToDate-CD-ROM, Wellesley, MA, 1998.

11) Hirschberg R: Side effects of long-term growth hormone therapy. In: Rose B: UpToDate in Nephrology, UpToDate-CD-ROM, Wellesley, MA, 1998.

12) Hirschberg R: Side effects of long-term growth hormone therapy. In: Rose B: UpToDate in Nephrology, UpToDate-CD-ROM, Wellesley, MA, 2000.

13) Hirschberg R: Insulin, Insulin-like Growth Factor-I, Somatostatin and Glucagon. In: Massry S and Glassock R (Edits): Text Book of Nephrology, 4th Edition, Williams and Wilkins, Baltimore, 2002.

14) Hirschberg R: Hormones and Renal Disease. In: Wass J and Shalet S (Edits): Oxford Text Book of Endocrinology and Diabetes, Oxford University Press, 2002.

15) Hirschberg R: Drug-nutrient Interactions in renal failure. Kopple J, Massry S (Edits), Nutritional management of renal disease, 2nd Edition, Lippincott Williams and Wilkins, Philadelphia, PA. 2003.

16) Hirschberg R: Ernährung des Hämo- und Peritonealdialyse Patienten. In: W Hörl, C Wanner (Edits), “Dialyseverfahren in Klinik und Praxis, 6. Auflage; Thieme, Stuttgart 2004.

17) Hirschberg R: Proteinuria and Interstitial Disease in Diabetic Nephropathy. In: Mogensen CE, Cortes P (Edits), 'Diabetic Nephropathy', Humana Press. 2007.

18) Park J, Hirschberg R: Hormones and the Kidney. In: Wass J and Shalet S (Edits): Oxford Text Book of Endocrinology and Diabetes, 2nd Edition, Oxford University Press,

17 Oxford, UK, 2011.

19) Hirschberg R: Drug-nutrient interactions in renal failure. In: Kopple J, Massry S and Kalantar-Zadeh K: Nutritional Management of Renal Disease. Third Edition. Elsevier, New York, 2012

Abstracts 1) Hirschberg R, K Schaefer, D von Herrath, G Kreutz, H Kewitz. Digoxin-quinidine

interaction in patients with renal failure. VIIIth Int Congr Nephrol, Athens, 1981. 2) Hirschberg R, H Rottka, D von Herrath, A Pauls, K Schaefer. Protein loading in

vegetarians: Varying effects on creatinine clearance. IXth Int Congr Nephrol, Los Angeles, 1984.

3) Kopple JD, Hirschberg R. Role of growth hormone in the amino acid induced increase in RPF and GFR. 5th Int Capri Conf on Uremia, Naples, 1986.

4) Hirschberg R, JD Kopple. Role of growth hormone in the amino acid induced increase in RPF and GFR. Kidney Int 29 (1986), 190. Ann Meeting Am Soc Nephrol, New Orleans, 1985.

5) Hirschberg R, JD Kopple. Indomethacin blocks the arginine induced rise of RPF and GFR in man. Kidney Int. 30 (1987), 201. Ann Meeting Am Soc Nephrol, Washington DC, 1986.

6) Ahmad S, T Golper, R Hirschberg, JD Kopple, L Katz, P Kurtin, D Ashbrook, M Wolfson. Efficacy of L-Carnitine in hemodialysis: A multi-center controlled clinical trial. Kidney Int 30 (1987), 226. Ann Meeting Am Soc Nephrol, Washington DC, 1986.

7) Hirschberg R, LA Slomowitz, JD Kopple. The amino acid induced rise in RPF and GFR is partially glucagon mediated and prostaglandin dependent. Xth Int Congr Nephrol, London, 1987.

8) Hirschberg R, A Cohen, JD Kopple. Effects of ketoacids on renal function in 5/6 nephrectomized rats fed a high protein diet. Xth Int Congr Nephrol, London, 1987.

9) Slomowitz L, R Bergamo, R Hirschberg, JD Kopple. Enalapril reduces albumin excretion in diabetic patients with microalbuminuria. Ann Meeting Am Soc Nephrol, Washington DC, 1987.

10) Rabb H, R Hirschberg, R Bergamo, JD Kopple. Temporal relationship between plasma growth hormone, plasma IGF I and renal function after growth hormone injection. Ann Meeting Am Soc Nephrol, Washington DC, 1987.

11) Hirschberg R, JD Kopple: Growth hormone and IGF-I modulate renal function. Fifth Intern Congr Nutr Metabol Renal Disease, Strasbourg, France, September 1988.

12) Hirschberg R, JD Kopple: Evidence that IGF-I increases RPF and GFR in fasted rats. Ann Meeting Am Soc Nephrol, San Antonio, Tx, 1988. Kidney Int 35 (1989), 312.

13) Slomowitz L, R Bergamo, R Hirschberg, M Grosvenor, J Kopple: Enalapril may block tubuloglomerular feedback in patients with diabetes mellitus. Ann Meeting Am Soc Nephrol, Washington DC, 1989. Kideny Int 37 (1990), 245.

14) Hirschberg R, JD Kopple, R Blantz, B Tucker: Effects of IGF-I on glomerular dynamics in rats. Ann Meeting Am Soc Nephrol, Washington DC, 1990.

15) Hirschberg R, B Tucker, R Blantz, JD Kopple. Effects of rhIGF-I on nephron dynamics in the rat. 2nd Int IGF Symp, San Francisco, 1991.

16) Hirschberg R, JD Kopple. Effects of rhIGF-I on renal dynamics in man. 2nd Int IGF Symp, San Francisco, 1991.

17) Hirschberg R, JD Kopple. The growth hormone-IGF-I axis and glomerular function. 6th Int Congress on Nutrition and Metabolism in Renal Disease, Harrogate, UK, 1991.

18 18) Hirschberg R, JD Kopple. The growth hormone IGF-I axis and glomerular function. Ann

Meeting Am Soc Nephrol, Baltimore, MD, 1991. 19) Hirschberg R, G Brunori, JD Kopple. Effects of recombinant human IGF-I on renal

glomerular and tubular function in man. Ann Meeting Am Soc Nephrol, Baltimore, MD, 1991.

20) Hirschberg R, JD Kopple: Rh growth hormone and des(1-3)IGF-I correct the reduced nephron ultrafiltration in growth hormone deficient rats. Ann Meeting Am Soc Nephrol, Baltimore, MD, 1991.

21) Hirschberg R, Nast C: Glomerulare Hypertrophie ist keine notwendige Voraussetzung fur glomerulare Sklerose bei subtotal nephrektomierten Ratten. Kongress der Gesellschaft fur Nephrologie, Hannover, FRG, 1992.

22) Ding H, Kopple J, Cohen A, Hirschberg R: IGF-I ameliorates renal damage in ischemic acute renal failure in the rat. Am Soc Nephrol, Baltimore, 1992.

23) Hirschberg R, Nast C: Glomerular sclerosis does not depend on glomerular hypertrophy in subtotally nephrectomized rats. Am Soc Nephrol, Baltimore, 1992.

24) Ding H, Hirschberg R, Kopple J: Recombinant human insulin-like growth factor I reduces catabolic rate in rats with acute renal failure. Am Soc Nephrol, Baltimore, 1992.

25) Feld S, Hirschberg R, Artishevsky A, Glassock R, Adler S: The effects of IGF-I and growth hormone on extracellular matrix mRNA in glomeruli and cultured mesangial cells. XIIth Int Congr Nephrol, Jerusalem, 1993.

26) Hirschberg R, Wanner C: IGF-I steigert die phosphat absorption und wirkt auf den kollagenstoffwechsel von epithelzellen des proximalen nephrons. Kongress der Gesellschaft fur Nephrologie, Hamburg, FRG, 1993.

27) Hirschberg R: Beim nephrotischen Syndrom wird IGF-I glomerular ultrafiltriert und kann via luminale Rezeptoren auf proximale Tubuluszellen wirken. Kongress der Gesellschaft fur Nephrologie, Hamburg, FRG, 1993.

28) Hirschberg R, Wanner C: Effects of IGF-I on phosphorus uptake by urinary space lining cells of the proximal nephron. Am Soc Nephrol, Boston, 1993.

29) Hirschberg R: IGF-I is ultrafiltered into the urinary space and may exert biological effects in proximal tubules in the nephrotic syndrome. Am Soc Nephrol, Boston, 1993.

30) Feld S, Hirschberg R, Artishevsky A, Nast C, Adler S: IGF-1 induces mesangial cell proliferation and increases mRNA and secretion of collagen. Am Soc Nephrol, Boston, 1993.

31) Hirschberg R: The glomerular ultrafiltration of IGF-I in the nephrotic syndrome. 7th Int Congr Nutr and Metab Renal Dis, Stockholm, 1994.

32) Hirschberg R: Vorlaufige Untersuchungen zur IGF-I Rezeptor Transduktion in Proximalen Tubuluszellen. Kongress der Gesellschaft fur Nephrologie, Zurich, 1994.

33) Hirschberg R: Selective increase of insulin-like growth factor-binding protein-2 gene expression and synthesis in the liver in nephrotic rats. Annual Meeting, Am Soc Nephrol, Orlando, Fl., 1994.

34) Hirschberg R: Evidence for biologic activity of tubule fluid IGF-I in rats with the nephrotic syndrome. Annual Meeting, Am Soc Nephrol, Orlando, Fl., 1994.

35) Ding H, Gao X, Hirschberg R, Kopple J: Mechanism of resistance to IGF-I in skeletal muscles of rats with chronic renal failure. Annual Meeting, Am Soc Nephrol, Orlando, Fl, 1994.

36) Nast C, Hirschberg R, Artishevsky A, Lapage J, Adler S: Misoprostol partially inhibits chronic cyclosporine nephrotoxicity. Annual Meeting, Am Soc Nephrol, Orlando, Fl, 1994.

37) Ding H, Gao X, Hirschberg R, Kopple J: Evidence for impaired activity of type I IGF receptor tyrosine kinase in skeletal muscle of rats with chronic renal failure. The

19 Endocrine Meetings, Washington DC, 1995.

38) Feld S, Figueroa P, Cha D, Savin V, Sharma R, Sharma M, Nast C, Hirschberg R, LaPage J, Adler S: Do circulating factors contribute to the proteinuria and matrix synthesis in the native kidneys of patients with idiopathic focal sclerosis? Am Soc Nephrol, San Diego, CA 1995.

39) Ding H, Quing P, Gao X, Hirschberg R, Kopple J: Time dependent changes in the expression of insulin-like growth factor I and IGF-I receptor in tisses oc rats with acute renal failure. Am Soc Nephrol, San Diego, CA 1995.

40) Vadgama J, Franklin K, Ding H, Chang K, Hirschberg R, Kopple J: Serum and skeletal muscle IGF-I and IGF-binding protein expression in rats with chronic renal failure. Am Soc Nephro, San Diego, 1995.

41) Bohe J, Ding H, Hirschberg R, Yoon K, Qing D, Wolfgang G, Kopple J: Insulin-like growth factor I affects the IGF binding protein profile in rats with acute renal failure. 8th Int Congr Nutr Metabol Ren Dis, Naples, Italy, 1996.

42) Hirschberg R, Kopple J, Guler H, Pike M and the Chiron Study Group: Recombinant human insulin-like growth factor I does not alter the course of acute renal failure in patients. 8th Int Congr Nutr Metabol Ren Dis, Naples, Italy, 1996.

43) Hirschberg R: Mechanisms of IGF-I-induced recovery of proximal tubular cells in primary culture after acute injury. Am Soc Nephrol, New Orleans, 1996. (J Am Soc Nephrol 7:1826, 1996)

44) Bohe J, Ding H, Hirschberg R, Yoon K, Quing D, Wolfgang G, Kopple J: Insulin-like growth factor binding proteins and IGFBP mRNAs in rats with acute renal failure given IGF-I. Am Soc Nephrol, New Orleans, 1996. (J Am Soc Nephrol 7:1653, 1996)

45) Kopple J, Hirschberg R, Guler H, Pike M and the Chiron Study Group: Lack of effect of recombinant human insulin-like growth factor I in patients with acute renal failure. Am Soc Nephrol, New Orleans, 1996. (J Am Soc Nephrol 7:1375, 1996)

46) Wang S, Hirschberg R: Possible pathophysiologic action of HGF through apical tubular membrane c-Met. Am Soc Nephrol, San Antonio, TX 1997; (J Am Soc Nephrol 8:632, 1997).

47) Wang S, Hirschberg R: TGF-beta in glomerular ultrafiltrate in experimental diabetic nephropathy.Am Soc Nephrol, San Antonio, TX 1997. (J Am Soc Nephrol 8:649, 1997).

48) Wang S, LaPage J, Hirschberg R: Pathophysiologic actions of ultrafiltered HGF through apical tubular membranes. Forefronts in Nephrology: Regulation of Renal Growth, Jackson Lake, WY, 1998.

49) Wang S, LaPage J, Hirschberg R: HGF and TGF-β in glomerular ultrafiltrate causes increased tubular expression and basolateral secretion of MCP-1 in diabetic nephropathy. Gorden Research Conference on Peptide Growth Factors, Meriden, NH, 1998.

50) Wang S, Hirschberg R: Ultrafiltered HGF and TGF-β cause tubular basolateral secretion of MCP-1 in diabetic nephropathy. Am Soc Nephrol, Philadelphia, PA 1998; (J Am Soc Nephrol 9:644A, 1998).

51) Wang S, Hirschberg R: Glomerular ultrafiltration of IGF-I may contribute to distal tubular sodium retention in diabetic nephropathy. Am Soc Nephrol, Philadelphia, PA 1998; (J Am Soc Nephrol 9:124A, 1998).

52) Wang S, LaPage J, Hirschberg R: Glomerular proteinuria may contribute to progressive interstitial fibrosis by indirect mechanisms. Am Soc Nephrology, 1999; (J Am Soc Nephrol 10:672A, 1999).

53) Hirschberg R, LaPage J, Wang S: Glomerular ultrafiltration of HGF and TGF-β induces tubular PDGF-B in experimental diabetic nephropathy. Am Soc Nephrology, 1999; (J Am Soc Nephrol 10:682A, 1999).

20 54) Hirschber R, LaPage J, Wang S: Direct mechanisms contributing to glomerular

proteinuria-induced interstitial fibrosis in diabetic nephropathy. Am Soc Nephrol, 1999; (J Am Soc Nephrol 10:547A, 1999).

55) Wang S, LaPage J, Hirschberg R: IGF-binding protein-related protein-2 may play a role in proteinuria-accelerated interstitial fibrosis in diabetic nephropathy. Am Soc Nephrology, 1999; (J Am soc Nephrol 10:690A, 1999).

56) Wang S, Hirschberg R: Glomerular ultrafiltration of TGF-β activates proximal tubular cells in the kidney in diabetic nephropathy. Symposium, TGF-β: Biological Mechanisms, NCI, NIH, Bethesda, MD 1999.

57) Wang S, Hirschberg R: Alterations in tubular cell BMP7 activity may contribute to tubulo-interstitial injury. Am Society of Nephrology, Toronto, Canada, 2000 (J Am Soc Nephrol 11:520A, 2000).

58) Wang S, Hirschberg R: Loss of renal tubular BMP7 during the evolution of experimental diabetic nephropathy. Am Society of Nephrology, Toronto, Canada, 2000 (J Am Soc Nephrol 11:655A).

59) Wang S, Hirschberg R: TGFß-induced epithelial-mesenchymal transdifferentiation of tubular cells. FASEB Summer Research Conference on TGF: Signaling and Development, Tuscon, AZ 2001.

60) Hirschberg R, Della Casa-Alberighi O, Hoexter G: Effect of lumiracoxib on blood pressure and fluid retention: Pooled analysis. American College of Rheumatology Annual Meeting, Orlando, FL, 2003.

61) Wang S, Hirschberg R: BMP7 is anti-fibrogenic in mesangial cells. World Congress of Nephrology, Berlin, Germany 2003; Nephrol Dial Transplant 18 (Suppl 4):584, 2003.

62) Wang S, LaPage J, Hirschberg R: Mechanisms of BMP7’s antagonism to TGF. World Congress of Nephrology, Berlin, Germany 2003; Nephrol Dial Transplant 18 (Suppl 4): 566, 2003.

63) Wang S, LaPage J, Hirschberg R: BMP7 opposes TGF-beta dependent fibrogenesis in mesangial cells. FASEB Summer Research Conference on TGF: Signaling and Development, Tuscon, AZ 2003.

64) Wang S, Hirschberg R: Competition between BMP7- and TGF-beta-dependent smad signals. Annual Meeting of the American Society of Nephrology, San Diego, CA, 2003; J Am Soc Nephrol 14:551A, 2003.

65) Wang S, Hirschberg R: BMP7 opposes TGF-beta-dependent fibrogenesis in mesangial cells through smad5 and smad6. Annual Meeting of the American Society of Nephrology, San Diego, CA, 2003; J Am Soc Nephrol 14:590A, 2003.

66) Hirschberg R, Della Casa Alberighi O, Hoexter G: Effect of lumiracoxib on blood pressure and fluid retention: A pooled analysis. Annual Meeting of the British Society of Rheumatology, Edinburgh, Scotland, 2003; Rheumatology (Oxford)

67) Wang S, Wilkes M, Leof R, Hirschberg R: Abelson tyrosine kinase is a smad-independent, co-stimulatory TGFβ-induced signal for renal fibroblast proliferation in-vitro and in-vivo. Annual Meeting of the American Society of Nephrology, St. Louis, MO, 2004.

68) Wang S, Hirschberg R: Imatinib mesylate is anti-fibrogenic in obstructive nephropathy. Annual Meeting of the American Society of Nephrology, St. Louis, MO, 2004.

69) Wang S, de Caestecker M, Kopp J, Mitu G, Hirschberg R: Transgenic renal expression of bone morphogenetic protein-7 (BMP7) protects from diabetic nephropathy. Annual Scientific Meeting of the American Society of Nephrology, Philadelphia, PA 2005.

70) Wang S, Mitu G, Hirschberg R: Bone morphonetic Protein-7 (BMP7) blocks diabetes-relevant podocyte injury. Annual Scientific Meeting of the American Society of Nephrology, Philadelphia, PA 2005.

21 71) Wang S, Mitu G, Hirschberg R: Bone Morphogenetic Protein -7 (BMP7) is a

differentiation- and antiapoptotic factor in podocytes with relevance to early diabetic injury. Annual Scientific Meeting of the American Society of Nephrology, San Diego, CA. J Am Soc Nephrol 17: 2A, 2006.

72) Hirschberg R, Mitu G, Wang S: The endothelium-podocyte symbiosis and glycemic injury. Annual Scientific Meeting of the American Society of Nephrology, San Diego, CA. J Am Soc Nephrol 17: 594A, 2006.

73) Hirschberg R, Wang S: Glycemia-induced endothelial cell proliferation is regulated through Alk1. Annual Scientific Meeting of the American Society of Nephrology, San Francisco, CA. J Am Soc Nephrol 18:391A, 2007.

74) Wang S, Leof E, Hirschberg R: The TGFβ-activated mTORC1 pathway contributes to renal interstitial fibrogenesis. Annual Scientific Meeting of the American Society of Nephrology, Philadelphia, PA 2008.

75) Nasseri D, Wang S, Hirschberg R: Abnormal priming of endothelial progenitor cells in diabetic subjects with renal disease. Annual Scientific Meeting of the American Society of Nephrology, Philadelphia, PA 2008.

76) Wang S, Hirschberg R: Y-Box Protein-1 is a transcriptional Regulator of BMP7. Annual Scientific Meeting of the American Society of Nephrology, San Diego, CA 2009.