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CURRICULUM VITAE PERSONAL DATA Name: Raffaella Last Name: Gozzelino Nationality: Italian Birth place and date: Cuneo (Italy) on March 19 th , 1976 Institucional address: Rua da Câmara Pestana, 1150-082 Lisbon, Portugal E-mail address: [email protected]; [email protected] WORK EXPERIENCES 2019 - present Director of the International BioIron Society (IBIS). 2019 - present Lecturer & Consultant at ENAGO Academy of Science. 2018 - present Scientific Advisor at Thelial Technologies S.A. for the Drug discovery and Development program TheBRAIN (Thelial BarrierReinforcement applied in Neurodegeneration). 2015 - present Assistant Professor at NOVA Medical School, NOVA University of Lisbon, Portugal. 2015 - present Group Leader. Inflammation and Neurodegeneration Laboratory, Chronic Diseases Research Centre (CEDOC), NOVA Medical School, Lisbon, Portugal. 2012 – 2015: Staff Scientist, Instituto Gulbenkian de Ciência, Oeiras, Portugal. 2007 – 2012: Post-doctoral Fellow (Immunology/Infection). Inflammation Laboratory, Instituto Gulbenkian de Ciência, Oeiras, Portugal. 2003 – 2007: PhD Student (Neuroscience/Neurobiology). Cell Signaling and Apoptosis Laboratory, Faculty of Medicine, University of Lerida – Arnau de Vilanova Hospital, Spain. 2002 – 2003: Scientific Advisor at WITT ITALIA S.p.A., Santena, Torino, Italy.

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CURRICULUM VITAE

PERSONAL DATA Name: Raffaella Last Name: Gozzelino Nationality: Italian Birth place and date: Cuneo (Italy) on March 19th, 1976 Institucional address: Rua da Câmara Pestana, 1150-082 Lisbon, Portugal E-mail address: [email protected]; [email protected]

WORK EXPERIENCES 2019 - present Director of the International BioIron Society (IBIS). 2019 - present Lecturer & Consultant at ENAGO Academy of Science. 2018 - present Scientific Advisor at Thelial Technologies S.A. for the Drug discovery and

Development program TheBRAIN (Thelial BarrierReinforcement applied in Neurodegeneration).

2015 - present Assistant Professor at NOVA Medical School, NOVA University of Lisbon, Portugal.

2015 - present Group Leader. Inflammation and Neurodegeneration Laboratory, Chronic Diseases Research Centre (CEDOC), NOVA Medical School, Lisbon, Portugal.

2012 – 2015: Staff Scientist, Instituto Gulbenkian de Ciência, Oeiras, Portugal. 2007 – 2012: Post-doctoral Fellow (Immunology/Infection). Inflammation Laboratory,

Instituto Gulbenkian de Ciência, Oeiras, Portugal. 2003 – 2007: PhD Student (Neuroscience/Neurobiology). Cell Signaling and Apoptosis

Laboratory, Faculty of Medicine, University of Lerida – Arnau de Vilanova Hospital, Spain.

2002 – 2003: Scientific Advisor at WITT ITALIA S.p.A., Santena, Torino, Italy.

CV: Raffaella Gozzelino

COMMISSIONS OF TRUST INTERNATIONAL PEER REVIEWER SERVICES FOR:

1) International Granting Agencies: (a) Austrian Science Fund (FWF – Austria; 2019 -present); (b) Foundation for Polish Science (FNP - Poland; 2018-present); (c) Research Foundation – Flanders (FWO - Belgium; 2018-present); (d) Italian Ministry of Education, Universities and Research (MIUR - Italy; 2018-present); (e) Israel Science Foundation (ISF - Israel; 2017-present); (f) Pfizer price (Portugal; 2016-present); (g) Medical Research Council (MRC)/DFID African Research Leader Scheme (UK; 2016-present); (h) Hungarian National Scientific Research Foundation (OKTA - Hungary; 2015-present); (i) French National Research Agency (ANR - France; 2015-present).

2) Applications for Professorship Appointment: Faculty of Medicine of the University of Zurich, Switzerland (2015);

3) Applications for Admission to International PhD Programs: Graduate Program Science for Development (PGCD; 2014-present).

4) International Scientific Journals: (a) Nature reports; Journal of Clinical Investigation; BioMed Research International; British Journal of Pharmacology; Clinical Intervention in Aging; Clinical Nutrition (2019-present); (b) British Journal of Pharmacology; Acta Haematologica; Metallomics; Neurochemistry international (2018-present); (c) Cells; Molecules (2018-present); (d) Journal of Visualized Experiments (JoVE; 2017-present); (e) Progress in Neurobiology (2017-present), (f) Journal of Inorganic Biochemistry (2017-present); (g) Acta Haematologica (2016-present); (h) International Journal of Experimental Pathology (2015-present); (i) Journal of Neurodegenerative Diseases (2015-present); (j) Trends in Molecular Medicine (2015-present); (k) Proceedings of the National Academy of Sciences (PNAS; 2015-present); (l) Journal of Free Radical Biology & Medicine (2014-present); (m) Arab Journal of Gastroenterology (2014-present); (n) Cellular and Molecular Life Sciences (2014-present); (o) PLoS One (2014-present) and (p) European Journal of Pharmacology (2012-present).

EDITORIAL BOARD MEMBER FOR INTERNATIONAL SCIENTIFIC JOURNALS: (a) BBA General Subjects (2018-present); (b) Pharmaceuticals (2017-present); (c) IUBMB Life (2017-present); (d) Frontiers in Neurology (2015-present); (e) Mediators of Inflammation (2015-present); (f); Frontiers in BioScience (2014-present); (g) Frontiers in Experimental Pharmacology and Drug Discovery (2012-present); (h) European Journal of Pharmacology (2012-present); (i) Frontiers in Pharmacology (2012-2016). TEACHING ACTIVITIES

1) National Appointments: (a) Assistant Professor at NOVA Medical School, University of Lisbon (undergraduate disciplines Tissue, Cells and Molecules; Molecular Mechanisms of Diseases; Inflammation and Immunology; PhD Graduate Program in Cellular and Molecular Mechanisms of Disease and Chronic Disease – ProRegeM); (b) Invited Professor at the University of Porto (PhD Graduate Program in Areas from Basic and Applied Biology - GABBA); (c) Invited Professor at the Faculty of Pharmacy, University of Lisbon (Master Program in Biopharmaceutical Sciences; (d) Invited Professor at the Institute of Hygiene and Tropical Medicine, Lisbon (Master Program in Infectious Diseases); (e) Invited Professor at the BioISI – Faculty of Science, University of Lisbon (Master Program in Biochemistry of Neurodegeneration).

CV: Raffaella Gozzelino

2) International Appointments: (a) Invited Professor at the Jean Piaget University, Cape Verde (Master Program in Infection and Tropical Diseases); (b) Invited Professor at the University of Cape Verde UniCV, Cape Verde (PhD Graduate Program Science for Development - PGCD).

OUTREACH ACTIVITY (a) Invited Lecturer and organizer of motivational courses on Women Empowerment and Science Promotion in Cape Verde (2018 - present); (b) Invited Lecturer at the Next Einstein Forum in Cape Verde (2018); (c) Invited Lecturer for motivational courses on Scientific Career Development. Faculty of Sciences, Caparica, Portugal (2016-2017); (d) Invited Lecturer for courses aimed at accrediting High School Teachers in Life Science Biology. Instituto Gulbenkian de Ciência, Oeiras, Portugal (2013-2014). STUDENTS MENTORING

1) Bachelor students: (a) Maria Araujo Vitoria (from Lisbon, Portugal - defended on July 12th, 2019; Evaluation obtained: 18/20); (b) Patricia Bernardo (from Evora, Portugal - defended on July 1st, 2019; Evaluation obtained: 18/20);

2) Master students: (a) Paula Isidora (thesis entitled: “Disruption of Heme / Iron homeostasis and low grade inflammation during aging” – defended at the University of Friburg, Germany, on June 12th, 2018; Evaluation obtained: Excellent); (b) Ana Catarina Guilherme Pêgo (thesis entitled: “Changes In Erythropoiesis And Transferrin Receptor 2 In Malaria-Induced Anemia” – defended on December 17th, 2018; Evaluation obtained: 20/20); (c) Maria Mariño Clar (thesis entitled: “Ferroptosis and the pro-inflammatory activation of microglia” – defended at the University of Girona, Spain, on February 6th, 2019; Evaluation obtained: Excellent); (d) Ana Rita Prada (thesis title: “b-amyloid and α-synuclein aggregation: the role of hemoproteins” – she will defend on November 20th, 2019); (e) Tomas Barros (thesis title: “Changes in the gut-brain axis during aging” – he will defend in September 2020).

3) PhD students: (a) Ana Catarina Guilherme Pêgo (thesis entitled: “Erythropoiesis in malaria infection: the dynamic interaction between inflammation and iron sensors” - Ref. SFRH/BD/148611/2019); (b) Mostafa Ejtehadifar (thesis title: “Iron in the brain: the role of HFE”); (c) Sara Bamdad (thesis title: “Systemic contribution to heart failure susceptibility – the crosstalk between inflammation and iron metabolism”); (d) Ana Catarina Vaz Carreto Martins (thesis entitled: “The role of immunity in neurodegenerative diseases” - Ref. SFRH/BD/104599/2014 - she will defend in 2020); (e) Illyane Sofia Martins Lima (thesis entitled “Heme/Iron-driven microglia polarization in Parkinson’s disease” - Ref. SFRH/BD/1114552/2016 - she will defend in 2020); (f) Antonino Kapitão (thesis entitled “Hemoglobinopathies and neurological damage” - Ref. SFRH/BD/135007/2017 - he will defend in 2020); (g) Raquel Delgado (thesis entitled “Regulation of survival and death signaling in CLL” – a study carried out at the Academic Medical Center, Amsterdam, The Netherlands - she will defend in 2020); (h) Gisela Silva Gordino (thesis entitled “Exploring the impact of gd-T cell subsets in motor performance and Parkinson’s disease progression” - Ref. SFRH/BD/128866/2017; a study carried out at the Institute of Molecular Medicine (IMM) in Lisbon); (i) Ana Martins Ribeiro (thesis entitled “Tissue Damage Control: Protection against necroptosis by the transcription factor NF-E2-related factor 2 (Nrf2)”; a study carried out at the Instituto Gulbenkian de Ciencia, Oeiras, Portugal, and defended in July 2017).

CV: Raffaella Gozzelino

4) Post-doctoral fellow: (a) Dr. Ines Tavares Pinto Sá Pereira (from June 2017 to February 2019 she was working on a project entitled “Systemic contribution to heart failure susceptibility – the crosstalk between inflammation and iron metabolism” - Ref. DAI/2017/17).

PARTICIPATION IN THESIS DEFENSE

1) PhD thesis committee member: (a) Pedro Dionisio’s thesis, entitled “Tuning Cell Death and Inflammation in Parkinson’s Disease”. Faculty of Pharmacy, University of Lisbon, Portugal (2020). (b) Yash Pandya’s thesis, entitled “The role of fetal Toll-like receptor 4 in the outcomes of a mouse model of placental malaria”. Instituto Gulbenkian de Ciência, Oeiras, Portugal (2019). (c) Joana Margarida Lopes da Silva Cristovão’s thesis, entitled: “The calcium binding S100B protein as a new modulator of amyloid-β peptide aggregation” (2019). (d) Maria Regoni’s thesis, entitled “Deletion of ferritin genes in cells and mice. The deficiency of mitochondrial ferritin reduces male fertility and that of cytosolic ferritins reduces cell resistance to oxidative damage”. University of Brescia, Italy (2017). (e) Marta Bento Afonso’s thesis, entitled “Targeting hepatocyte necroptosis to treat liver disease”. Faculty of Pharmacy, University of Lisbon, Portugal (2017). (f) Milene Soraia Costa da Silva’s thesis, entitled “Heme and iron shape macrophage plasticity: a role in haemolytic disorders and cancer?”. Instituto de Ciências Biomédicas Abel Salazar, University of Porto, Portugal / University of Heidelberg, Germany (2016); (g) Liliana Alves da Silva Marques’s thesis, entitled “Iron homeostasis in immune mononuclear cells: a potential role in atherogenesis”, Faculty of Sciences of the University of Lisbon, Portugal (2015); (h) Maria Linares’ thesis, entitled “Factores neuroprotectores y redox en el desarollo del fenotipo neurológico de la malaria cerebral murina”, University Computense of Madrid, Spain (2011).

2) Master thesis committee member: (a) Joana Dias Meda’s thesis, entitled “Investigating point mutations in genes of Plasmodium falciparum associated with anti-malaric resistance in Timor Leste”, Institute of Hygiene and Tropical Medicine, University of Lisbon, Portugal (2017); (b) Nuno Soares’s thesis, entitled “Non-cell autonomous neuroprotective effect of carbon monoxide: microglia-to-neuron communication”, Faculty of Sciences and Technologies of the University of Lisbon, Portugal (2015); (c) Claudia Figueiredo Pereira’s thesis, entitled “Carbon monoxide, autophagy and cytoprotection in response to cerebral ischemia”, Faculty of Sciences and Technologies of the University of Lisbon, Portugal (2015).

PARTICIPATION IN SCIENTIFIC THESIS COMMITTEE (a) Helio Rocha PhD thesis. Institute of Hygiene and Tropical Medicine, Belem, Portugal (2017-present); (b) Margarida Lopes da Silva Cristovão PhD thesis. BioISI – Faculty of Science, Lisbon (2015-2019). PRIZES/AWARDS 2019: ESNM – TANDEM award 2019 (attributed to one of my PhD students, Ms.

Ana Catarina Guilherme Pêgo) 2018: (a) Collaborative Investigation Price - Santander-Totta, (b) Best Poster

Presentation Award (19th biennial meeting for the Society for Free Radical Research International, SFRRI).

2017: Tribute by the Cape Verde’s Embassy in Lisbon for scientific merit, dedication and contribution as Woman In Science.

CV: Raffaella Gozzelino

2016: (a) Springer Book Voucher Award for Best Presentation (Understanding the Molecular Brain in Health and Disease Symposium) (b) Best Poster Presentation Award (International Heme Oxygenase Meeting).

2015: (a) Elsevier Award for Outstanding Contribution (b) Frontiers Award for Outstanding Contribution (c) Gunshin Levy Award (International BioIron Society) (d) Pfizer Price.

2013: Best podium presentation (International BioIron Society) FELLOWSHIPS AWARDED 2016 – 2021: FCT Investigator Programme Fellowship (Ref. IF/01495/2015).

Portuguese Government (5 years). 2015 – 2016: Invited scientist fellowship (Ref. BCC-A - iNOVA4Health-Multi/04462). FCT

Fundação para Ciência e a Tecnologìa. Portuguese Government (1 year). 2008 – 2015: Post-doctoral fellowship (Ref. SFRH/BPD/44256/2008). FCT Fundação

para Ciência e a Tecnologìa. Portuguese Government (3 years fellowship + 3 years renewal).

2003 – 2007: PhD fellowship (Ref. 2004FI 00108). Agència de Gestió d'Adjuts Universitaris i de Recerca. Catalunya Government (4 years fellowship).

PARTICIPATION IN PROJECTS AWARDED As Principal Investigator: Collaborative Investigation Price – Santander Totta/NOVA University of Lisbon. Stress-induced neuroinflammation: mechanisms and implications for decision-making and performance. From 2018 to 2021. EOS – The Excellence of Science (30826052). MOlecular mechanisms of cellular DEath and Life decisions in Inflammation, Degeneration and Infection. From 2018 to 2022. Fundação pela Ciência e Tecnologia - Investigator Programme (IF/01495/2015). Immunity and inflammation in Parkinson’s disease. From 2017 to 2018. Fundação pela Ciência e Tecnologia - Programas de Atividades Conjuntas (PAC) (03/SAICT/2015). NEw Targets in DIAstolic heart failure: from coMOrbidities to persoNalizeD medicine (NETDIAMOND). From 2017 to 2019. BD Biosciences Immunology Grant Fall 2015. Immune regulation of bone morphogenic pathways in Axial Spondyloarthritis. From 2015 to 2017. iNOVA4Health-Multi/04462 – Programme in Translational Medicine. The importance of Haptoglobin/Hemopexin axis in the pathogenesis of Axial Spondyloarthritis. From 2015 to 2018. As Team Member: In vitro and in vivo analysis of Ret mutants. Ministerio de Educacion y Ciencia. Spanish Government. BFU2004-03632. From 2004 to 2009. Principal Investigator: Mario Encinas Martin. Implication of the death receptor Fas and its functional antagonists in the neuronal aopoptotic cell death. Ministerio de Sanidad y Consumo. Catalonia Government. FIS PI020051. From 2002 to 2005. Principal Investigator: Joan X. Comella Carnicé.

CV: Raffaella Gozzelino

As Consultant: DAMAGECONTROL. European Research Council, 7th Framework Grant ERC-2011-AdG. 294709. Consultancy service from 2012 to 2014 (Specific Aim 1 of the aforementioned grant). Principal Investigator: Miguel P. Soares. Fundação pela Ciência e Tecnologia – Research Grant PTDC/IVC-ESCT/0073/2014. Consultancy service from 2016 to 2019. Principal investigator: Ana Margarida Grenho Ferreira. MEMBER OF: (a) European Society of Neurogastroenterology and Motility (ESNM; 2019-present); (b) European Crohn’s and Colitis Organization (ECCO; 2017-present); (c) European Hematology Association (EHA; 2017-present); (d) European Iron Club (EIC; 2014-present); (e) International BioIron Society (IBIS; 2012-present); (f) Portuguese Society of Immunology (SPI; 2011-present). ACADEMIC DEGREES 2003 – 2007: PhD Thesis in Cell Biology/Neurobiology, entitled “Implication of TNF

superfamily receptors and their functional antagonists in neuronal apoptotic cell death”. Classification: Excellent (Maximum). Cell Signalling and Apoptosis Laboratory, Faculty of Medicine, University of Lerida – Arnau de Vilanova Hospital, Spain.

2006 – 2007: PhD external training in Cell Biology and Immunology (Neurobiology/Autoimmune diseases). Project entitled “Assessment of the cytoprotective effect of heme oxygenase-1 in death receptor mediated olygodendrocyte injury”. Inflammation Laboratory, Instituto Gulbenkian de Ciencia, Oeiras, Portugal.

2003 – 2005: Diploma Advanced Studies (DEA) in Cell Biology/Neurobiology (Master equivalent). Classification: Excellent (Maximum). Cell Signalling and Apoptosis Laboratory, University of Lerida – Arnau de Vilanova Hospital, Spain.

1995 – 2001: Bachelor’s degree and MSc in Chemistry Pharmaceutical Technologies (specialization in Pharmacology). Classification: 106/110. Faculty of Pharmacy, University of Parma, Italy.

2000 – 2001: Undergraduate student researcher (Cell Biology) Project entitled “Induction of HSP70 in human fibroblasts during aging in vitro”. Dep. of Medicine and Experimental Pharmacology, University of Parma, Italy.

POST-GRADUATION COURSES 2015: Grant Writing Intensive. Lisbon, Portugal 2013: Drugs and the Brain. Online course offered by California Institute of

Technology (Caltech). 2012: (a) Writing in the Sciences. Online course offered by University of

Stanford. (b) Experimental Genome Science. Online course offered by University of Pennsylvania

2010: Practical Course on Image Acquisition in Immunology. Instituto Gulbenkian de Ciência, Oeiras, Portugal.

2005: (a) Diploma in Genetic Manipulation and Practical Animal Handling (FELASA, category C). University of Lerida, Spain. (b) Pathological Diseases and Molecular Therapy. University of Lerida, Spain.

CV: Raffaella Gozzelino

2005: 2002:

(c) Methods in Biochemistry and Molecular Biology. University of Lerida, Spain. (d) Methods in Cellular Biology. University of Lerida, Spain. Therapeutic Phytochemistry. Centro la Torre, Torino, Italy.

PUBLICATIONS Ferreira A, Neves P, Gozzelino R. Multilevel impacts of iron in the brain: cross talk between neurophysiological mechanisms, cognition and social behavior. Pharmaceuticals. 2019 Aug 29;12(3). Ramos S, Carlos AR, Sundaram B, Jeney V, Ribeiro A, Gozzelino R, Bank C, Gjini E, Braza F, Martins R, Ademolue TW, Blankenhaus B, Gouveia Z, Faísca P, Trujillo D, Cardoso S, Rebelo S, del Barrio L, Zarjou A, Bolisetty S, Agarwal A & Soares MP. Renal Control of Disease Tolerance To Malaria. Proc Natl Acad Sci U S A. 2019 Mar 19;116(12):5681-5686. Agoro R, Benmerzoug S, Rose S, Bouyer M, Gozzelino R, Garcia I, Ryffel B, Quesniaux VFJ and Mura C. Iron-rich diet decreases mycobacterial burden and correlates with hepcidin upregulation, lower pro-inflammatory mediators and higher T cell recruitment in a model of M. bovis BCG infection. The Journal of Infectious Diseases, 2017, Oct 17;216(7):907-918. Martins AC, Lima IS, Almeida JI, Kapitão AS and Gozzelino R. Iron metabolism and the inflammatory response. IUBMB Life 2017, Jun;69(6):442-450. Gozzelino R* and Arosio P*. Iron homeostasis in health and disease. Int J Mol Sci. 2016 Jan 20;17(1)(* equal contribution). Gozzelino R. The pathophysiology of heme in the brain. Curr Alzheimer Res. 2016;13(2):174-84. Arosio P, Carmona F, Gozzelino R, Maccarinelli F, Poli M. The importance of eukaryotic ferritins in iron handling and cytoprotection. Biochemical Journal. Biochem J. 2015 Nov 15;472(1):1-15. Gozzelino R* and Arosio P*. The importance of iron in pathophysiologic conditions. Frontiers Research Topic E-book, Publisher: Frontiers Media SA, ISBN: 978-2-88919-524-4. 2015 (* equal contribution). Gozzelino R* and Arosio P*. The importance of iron in pathophysiologic conditions. Editorial comment, Front Pharmacol. 2015 Feb 24;6:26 (* equal contribution). Yilmaz B, Portugal S, Tran TM, Gozzelino R, Ramos S, Gomes J, Regalado A, Cowan PJ, d’Apice AJF, Chong AS, Doumbo OK, Traore B, Crompton PD, Silveira H and Soares MP. Gut microbiota elicits a protective immune response against malaria transmission. Cell. 2014 Dec 4;159(6):1277-89. Soares MP, Gozzelino R and Weis S. Tissue damage control in disease tolerance. Trends Immunol. 2014 Aug 30. Penha-Gonçalves C, Gozzelino R and Vieira de Morais L. Iron overload in Plasmodium-infected placenta as a pathogenesis mechanism underlying poor fetal viability. Front Pharmacol. 2014 Jul 1;5:155. Gozzelino R* and Soares MP*. Coupling heme and iron metabolism via Ferritin H chain. Antioxid Redox Signal. 2014 Apr 10 (* equal contribution).

CV: Raffaella Gozzelino

Figueiredo N, Chora A, Raquel H, Pejanovic N, Pereira P, Hartleben B, Neves-Costa A, Moita C, Pedroso D, Pinto A, Marques S, Faridi H, Costa P, Gozzelino R, Zhao JL, Soares MP, Gama-Carvalho M, Martinez J, Zhang Q, Döring G, Grompe M, Simas JP, Huber TB, Baltimore D, Gupta V, Green DR, Ferreira JA, Moita LF. Anthracyclines induce DNA damage response-mediated protection against severe sepsis. Immunity. 2013 Nov 14;39(5):874-84. Marques-Fernandez F, Planells-Ferrer L, Gozzelino R, Galenkamp K, Reix S, Llecha-Cano N, Lopez-Soriano J, Yuste VJ, Moubarak R, and Comella J. TNFα induces PC12 cells survival through the FLIP-L-dependent activation of the MAPK/ERK pathway. Cell Death Dis. 2013 Feb 14;4:e493. Casanelles E*, Gozzelino R*, Marques-Fernandes F, Iglesias-Guimarais V, Sole C, Comella JX, Yuste V. Bcl-xL, but not Mcl-1, Bcl-2 or Bcl-w, controls TNF-triggered apoptosis regardless of NF-kB activation in HeLa cells. Biochim Biophys Acta. 2013 Jan 28 (* equal contribution). Gozzelino R, Andrade BB, Larsen R, Luz NF, Vanoaica L, Seixas E, Coutinho A, Cardoso S, Rebelo S, Poli M, Barral-Netto M, Darshan D, Kühn L, Soares MP. Metabolic adaptation to tissue iron overload confers tolerance to malaria. Cell Host Microbe. 2012 Nov 15;12(5):693-704. Larsen R, Gouveia Z, Soares MP, Gozzelino R. Heme Cytotoxicity And The Pathogenesis of Immune Mediated Inflammatory Diseases. Front Pharmacol. 2012;3:77. Gozzelino R and Soares MP. Heme sensitization to TNF-mediated programmed cell death. Book chapter in Advances in Experimental Medicine and Biology. Editors: David Wallach or Mark Feldmann. Springer-Verlag. Berlin Heidelberg. 2011;691:211-9. Larsen R, Gozzelino R, Jeney V, Tokaji L, Bonaparte D, Cavalcante M, Chora Â, Ferreira A, Marguti I, Cardoso S, Sepulveda N, Smith A, Soares MP. Targeting free heme to suppress the pathogenesis of severe sepsis. Sci Transl Med. 2010 Sep 29;2(51):51ra71. Moubarak RS, Solé C, Pascual M, Gutierrez H, Llovera M, Pérez-García MJ, Gozzelino R, Segura MF, Iglesias-Guimarais V, Reix S, Soler RM, Davies AM, Soriano E, Yuste VJ, Comella JX. The death receptor antagonist FLIP-L interacts with Trk and is necessary for neurite outgrowth induced by neurotrophins. J Neurosci. 2010 Apr 28;30(17):6094-105. Gozzelino R, Jeney V, Soares MP. Mechanisms of cell protection by heme oxygenase-1. Annual Rev Pharmacol Toxicol. 2010;50:323-54. Review. Seixas E*, Gozzelino R*, Chora A, Ferreira A, Silva G, Larsen R, Rebelo S, Penido C, Smith NR, Coutinho A, Soares MP. Heme oxygenase-1 affords protection against noncerebral forms of severe malaria. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15837-42. (* equal contribution) Gozzelino R, Sole C, Llecha N, Segura MF, Moubarak RS, Iglesias-Guimarais V, Perez-Garcia MJ, Reix S, Zhang J, Badiola N, Sanchis D, Rodriguez-Alvarez J, Trullas R, Yuste VJ, Comella JX. Bcl-xL regulates TNF-alpha-mediated cell death independently of NF-kB, FLIP and IAPs. Cell Res. 2008 Oct;18(10):1020-36. Segura MF, Sole C, Pascual M, Moubarak RS, Perez-Garcia MJ, Gozzelino R, Iglesias V, Badiola N, Bayascas JR, Llecha N, Rodriguez-Alvarez J, Soriano E, Yuste VJ, Comella JX. The long form of Fas apoptotic inhibitory molecule is expressed specifically in neurons and protects them against death receptor-triggered apoptosis. J Neurosci. 2007 Oct 17;27(42):11228-41. Sole C, Dolcet X, Segura MF, Gutierrez H, Diaz-Meco MT, Gozzelino R, Sanchis D, Bayascas JR, Gallego C, Moscat J, Davies AM, Comella JX. The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kB signaling. J Cell Biol. 2004 Nov 8;167(3):479-92. Epub 2004 Nov 1.

CV: Raffaella Gozzelino

ORGANIZATION OF INTERNATIONAL CONFERENCES AND/OR PARTICIPATION IN INTERNATIONAL SCIENTIFIC COMMITTEE MEETINGS 2020: Cape-Verdean diaspora congress, March 5-7, Praia, Cape Verde

(Member of the Executive Commission - Organizing committee). 2019: Neurogastro TANDEM meeting, September 2-4, Lisbon, Portugal

(Organizing committee). 2019: European Society of Neurogastroenterology and Motility meeting,

September 5-7, Lisbon, Portugal (Organizing committee). 2019: European Hematology Association meeting, June 13-16, Amsterdam,

The Netherlands (Scientific Committee). 2019: 8th Congress of the International BioIron Society, May 5-10,

Heidelberg, Germany (Scientific Committee). 2017: iNOVA4Health Symposium on Inflammation, March 17, Lisbon,

Portugal (Organizing committee) 2014: European Iron Club 2014, September 11-14, Verona, Italy (Scientific

Committee). CHAIRMAN AT INTERNATIONAL AND NATIONAL CONGRESSES 2019: NeuroGASTRO Meeting 2019, September 5-7, Lisbon, Germany. 2019: 8th Congress of the International BioIron Society, May 5-10,

Heidelberg, Germany. 2018 European Iron Club (EIC), February 08-11, Zurich, Switzerland. 2016: (a) 1st CEDOC Symposium on Chronic Diseases, June 30-July 1.

Lisbon, Portugal (b) European Iron Club (EIC), April 07-10, Innsbruck, Austria.

2015: (1) Annual Meeting of the Portuguese Society for Immunology (SPI), October 26-28, Braga, Portugal; (2) 20th congress of the European Hematological Association (EHA), June 11-14, Vienna, Austria.

2014: European Iron Club (EIC) 2014, September 11-14, Verona, Italy. INVITED PLENARY LECTURES AT NATIONAL AND INTERNATIONAL CONGRESSES Gozzelino R. Title to be defined. Iron, Reactive Oxygen Species & Ferroptosis in Life, Death & Disease. Suzhou, China. April 20-24th, 2020. Gozzelino R. Necroptosis in Parkinson’s disease. EOS Symposium. Brussels, Belgium. November 15th, 2019.

Gozzelino R. The Iron Status in Malaria Infection. Highlights of Past European Hematology Association (EHA) - (HOPE) Middle East & North Africa (MENA) 2019 – Cairo, Egypt. September 12-14th, 2019. Gozzelino R. Animal models of Parkinson’s disease. European Society of Neurogastroenterology and Motility (ESNM) meeting, Lisbon, Portugal. September 5-7th, 2019.

Gozzelino R. Iron in Malaria. European Hematology Association (EHA) – Amsterdam, The Netherlands. June 13-16th, 2019. Gozzelino R. Women in STEM. Next Einstein Forum – Africa Science Week, Praia, Cape Verde. October 22-26th, 2018.

CV: Raffaella Gozzelino

Gozzelino R. From mice to humans. 2nd PhD CEDOC Symposium, Lisbon, Portugal. October 19th, 2018. Gozzelino R. Inflammation, Iron and Parkinson’s disease. Fall Meeting 2018. Ulm, Germany. October 9-13th, 2018. Gozzelino R. The interplay between inflammation, stress and iron metabolism. Stress and decision-making FCSH Symposium, Lisbon, Portugal. June 11th, 2018. Gozzelino R. Iron and the brain: a role in neurodegenerative diseases. European Iron Club (EIC). Zurich, Switzerland. February 9th, 2018. Gozzelino R. Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease. EOS Symposium. Ghent, Belgium. November, 22th, 2017. Gozzelino R. Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease. MRC/LMB Symposium. Cambridge, UK. October, 13th, 2017. Gozzelino R. Inflammation-driven disruption of Iron homeostasis in Parkinson’s disease, Toronto, Canada. Invited by ApoPharma. July, 12th, 2017. Gozzelino R. Iron and Neurobiology. New Horizons in Iron Biology Symposium, Porto, Portugal. June 16th 2017. Gozzelino R. Inflammation-driven disruption of iron homeostasis in Parkinson’s disease. 7th Meeting of the International BioIron Society. Los Angeles, US. May 7-11th 2017. Gozzelino R. Iron and Inflammation in Parkinson’s disease. Understanding the Molecular Brain in Health and Disease BioISI Symposium. Lisbon, Portugal. June 29th, 2016. Gozzelino R. Inflammation-driven Heme/iron Cytotoxicity in Parkinson´s Disease. Immunology IMM Meeting, Lisbon. Portugal. October 16th, 2015. Gozzelino R. Inflammation-driven Heme/Iron cytotoxicity in Parkinson’s Disease. 6th Meeting of the International BioIron Society. Hangzhou, China. September 06-10, 2015.

Gozzelino R. Hepcidin in the brain. GABBA/IBMC SYMPOSIUM: Beyond the hepcidin consensus: new frontiers Symposium. Institute for Molecular and Cell Biology (IBMC), Porto, Portugal. May 22th, 2015. ORAL PRESENTATIONS AT INTERNATIONAL CONGRESSES Pêgo A, Lima IS, Martins G, Sá Pereira I, Martins AC, Kapitão AB, Camaschella C, Nai A, Silvestri L & Gozzelino R. Changes in erythropoiesis in malaria-induced anemia. EHA-SWG Scientific Meeting on Red Cell and Iron Metabolism Defects: From basic science to clinical case application – Madrid, Spain. November 7-9th, 2019. Martins C, Lima I, Sá Pereira I, Pêgo A, Martins G and Gozzelino R. Changes in gut microbiota: an early event in Parkinson’s disease. 8th Congress of the International BioIron Society, May 5-10, 2019. Heidelberg, Germany. Martins C, Lima I, Sá Pereira I, Pêgo A, Martins G and Gozzelino R. Ferroptosis in Parkinson’s disease. 2nd Congress of the Excellence of Science, March 7-8, 2019, Liege, Belgium.

CV: Raffaella Gozzelino

Ramos S, Sundaram B, Tolosano E, Gozzelino R and Miguel P. Soares. Kidney proximal tubular epithelial cells control disease tolerance to malaria by maintaining heme/iron homeostasis. 9th International Conference On Heme Oxygenase. Prague, Czech Republic, September 14-17, 2016. Martins C, Ramos S, Lima I and Gozzelino R. Inflammation-driven disruption of iron homeostasis: a risk factor for the development of Parkinson’s disease. European Iron Club. Innsbruck, Austria. April 7-10, 2016. Moraes L, Gozzelino R, Sousa P, Penha-Gonçalves C. Plasmodium infection during pregnancy disrupt iron homeostasis in the placenta. EMBL Conference BioMalPar XI, Biology and Pathology of the Malaria Parasite. Heidelberg, Germany. May 11-13, 2015. Gozzelino R, Bezerril Andrade B, Larsen R, Luz NF, Vanoaica L, Seixas E, Coutinho A, Cardoso S, Rebelo S, Poli M, Barral-Netto M, Darshan D, Kuhn LC, Soares MP. Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria. 5th Meeting of the International BioIron Society. London, UK. April 14-18, 2013. Gozzelino R, Larsen R, Vanoaica L, Seixas E, Poli M, Coutinho A, Cardoso S, Rebelo S, Darshan D, Kühn L, Soares MP. Ferritin H chain affords tolerance to Plasmodium infection. Meeting of Plataforma Ibérica de Malária. Lisbon, Portugal. June 22-24, 2011. Gozzelino R, Seixas E, Chora A, Ferreira A, Silva G, Larsen R, Rebelo S, Penido C, Smith NR, Coutinho A, Soares MP. Heme sensitization to TNF-mediated programmed cell death dictates the outcome of Plasmodium infection in mice. 2009 4th Meeting of the International BioIron Society. Porto, Portugal. June 07-11, 2009. Gozzelino R, Seixas E, Chora A, Ferreira A, Silva G, Larsen R, Rebelo S, Penido C, Smith NR, Coutinho A, Soares MP. Heme sensitization to TNF-mediated programmed cell death dictates the outcome of Plasmodium infection in mice. 12th International TNF Conference. Madrid, Spain. April 26-29, 2009. Gozzelino R, Sole C, Llecha N, Segura MF, Trullas R, Comella JX. TNF signaling mechanism inducing neuronal apoptotic cell death. Caracterizacíon del mecanismo de Bioquímica y Biología Molecular. Sociedad Española de Bioquímica Y Biología Molecular. Zaragoza, Spain. September 12-15, 2005. Gozzelino R, Solé C, Segura MF, Comella JX. Regulación de las vías de supervivencia y apoptosis por TNF en sistema nervioso. ApoRed, Red Española de Apoptosis. Miraflores de la Sierra (Madrid), Spain. May-June 28-01, 2005. Gozzelino R, Segura MF, Solé C, Comella JX. Caracterización molecular de la muerte inducida por TNF en células PC12. Implicación de la via de NF kappa B. II Reunión anual de la RED del FIS sobre muerte neuronal. Madrid, Spain. November 8-9, 2004. Gozzelino R, Segura MF, Solé C., Comella JX. TNFalpha signaling mechanism inducing cell death. Sociedad Española de Bioquímica y Biología Molecular. Lerida, Spain. September 12-15, 2004. Gozzelino R, Segura MF, Solé C, Comella JX. Dual mechanism of cell death after TNFalpha treatment in PC12 cells. Red de grupos de muerte neuronal en modelos animales y patología. Sant Feliu de Guixols, Spain. October 22-24, 2003.

CV: Raffaella Gozzelino

LANGUAGES Italian and Portuguese-based Creole (Cape Verde) – Mother tongue English – Fluent (written and spoken) Portuguese – Fluent (written and spoken) Spanish – Fluent (written and spoken)