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Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

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Page 1: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Radiological syndroms

Alveolar syndrome

Bronchial syndrome

Interstitial syndrome

Vascular syndrome

Mediastinal Syndrome

Page 2: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Alveolar syndrome

Page 3: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Pulmonary architecture : Morphological unit is the lobule

15-25mm

Page 4: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Lobule : morphological unit , smallest anatomical unit, ventilated by the centro lobular bronchiole accompanied by the centro lobular arterydimension: 1 à 2,5 cmcomposed of 3 to 5 acinus

Acinus : functional unit

Acinus

LobuleAcinus & lobule

14 divisions between the tracheaand the terminal bronchiole

1 et 1‘ bronchiole & centro lobular artery

2. bronchiole & terminal artery 3. respiratory bronchiole4. Alveolar duct5. Alveolar bag6. Alveolus 7. Perilobular vein + lymphatic vessels

Perilobular interstitial

tissue

Page 5: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Features of alveolar syndrome

• Blurred, heterogeneous opacity• Not well limited (except if there is contact

with one fissure, then the consolidation is “systematised“)

• With sometimes aeric bronchogram • No retraction in acute phase (but

retraction is possible if chronic evolution)

Page 6: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Blurred, heterogeneousNot well limited

Alveolar consolidation

Right UpperLobe

Pneumonia

But sharp boundary if contact with a fissure

Small fissureSmall fissure

Page 7: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Systematised opacity with aeric bronchogram

Page 8: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Acute* alveolar syndrome - Main etiologies

*The more frequent

Located

Infections (bacterial, viral)   Tuberculosis 

DiffuseInfections (bacterial,viral,opportunistic)  TuberculosisPulmonary oedema 

Localized pulmonary oedemaLung infarctus and embolism  Lung traumatism  Post radiotherapy (acute phase )  Mycosis  Loeffler syndrome Alveolar sarcoidosisBroncho alveolar cancer

Traumatism (contusion, fat embolism)  Angeitis  Pulmonary haemorrhage  Loeffler syndrome, eosinophilic lung  Hypersensibility pneumonia (allergic alveolitis)

> 90 % of cases

> 90 % of cases

Page 9: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Chronic* alveolar syndrome - Main etiologies

Located

Diffuse

Chronic pneumonia   Chronic pneumonia with eosinophilia   Bronchiolo-alveolar cancer   Lymphoma and haemopathy  

* Much less common than acuteshould be referred to a pulmonologist

Diffuse bronchiolo-alveolar damage  Lymphoma and haemopathy  Sarcoidosis  Pulmonary alveolar proteinosis  Lipidic pneumonia  desquamative interstitial pneumonia 

Page 10: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Right upper lobe pneumonia (Streptoccocus pneumoniae)

Young man with no medical historyFever, chills, sudden onset with right chest pain and purulent sputum

• Heterogeneous • Sharp boundary in contact with a fissure• Aeric bronchogramme • No retraction in acute phase

Page 11: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Right lower lobe pneumonia(S. pneumoniae)

Page 12: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Bacterial pneumonia are often caused by ear-nose-throat and dental infections and by Flu

Page 13: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

F. 50 y Day 6 of a Flut° 40°, cough and sore

spot right chestvery limited area of crackles

in right scapular region

Right upper lobe pneumonia

Page 14: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Evolution day 10

Rapid clinical improvement with Amoxicillin

Slower radiological improvement

Page 15: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Bifocal infection : RUL external segment and left lower lobe

Page 16: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Bilateral tuberculosis pneumonia

Cough, asthenia, loss of weight since 4 weeks

AFB (acid fast bacilli) + in sputum

Page 17: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Retractile evolution with treatment

Page 18: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

TB pneumonia is frequent in countries with high incidence of TB in HIV + patients, but also in HIV -

HIV - HIV+ HIV+

In case of AIDS : mediastinal adenopathies are often associatedand TB pneumonia is often located in the lower lobes

If the immunosuppression is severe, the cavities are rare

RUL Excavated pneumonia Pneumonia + adenopathies RLL pneumonia + adenopathies

Page 19: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Man 30 y old HIV+

Right upper lobe and middle lobe pneumonia Hilar and mediastinum

adenopathiesAFB sputum negative

Bronchial aspiration and BAL (bronchiolo alveaolar lavage) :

AFB +

Fistulised node on endoscopic view

This image is typical of TB/HIV

Page 20: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Excavated opacity of the inferior lobe, apical segment, AFB+

African officer in internship in France, t° 37°8C, stable condition, no functional or respiratory signs

Page 21: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Pneumonia withAeric bronchogramme

Cavern

Micro nodules

Page 22: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Legionnaires’ diseaseLegionella pneumophila

Man, 50 years old, fever, cough, dyspnea, headache,abdominal pain. Worsening despite  amoxicillin treatment 

Page 23: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Man, 35 years old, dyspnea and severe hypoxemia. Treatment by amoxicilline 3 g per day. (1)

Page 24: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Worsening at J4. Modification of treatment and introduction of erythromicin IV 3g/24h. Improvement in few days :

Mycoplasma pneumoniae (2)

Page 25: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

F 30 y HIV +Central African Rep.Bilateral pneumonia unimproved under

Amoxycillin

Page 26: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Alveolar form of pneumocystosis

RARE

PJP - Allergy to Bactrim=> dapsone

Improvement S3

Aeric bronchogramme

 Broncho Alveolar  Lavage : PJP

Page 27: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

• Consider to switch to macrolides• Do not use fluoroquinolones• Ask for HIV status

If the alveolar syndrome is chronicYou must consider an alternative diagnosis

If patient does not improve under amoxicilline and has not evident TB (AFB neg in sputum +/- Xpert negative)

Lymphoma, bronchiolo-alveolar carcinoma,….and refer to a pulmonology ward

Page 28: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Bronchiolo-alveolar carcinoma

Page 29: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome
Page 30: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Bronchiolo-alveolar carcinoma

Page 31: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Pulmonary oedema   alveolar syndrome

• Hemodynamic oedema  : result of left ventricular failure • with pulmonary arterial hypertension, of  post-capillar type. • Medical treatment is usually effective (O2, diuretic, TNT..) • There is no anatomic lesion of the “alveolar capillary barrier“

2 physiopathological mechanisms :

• Lesional edema also called Acute Respiratory Distress Syndrom ARDS): The “alveolar capillary barrier“ is more or less irreversibly altered.The prognosis is most often dismal. Death may occur by  refractory hypoxemia The etiologies are varied :

• infectious (viral or bacterial)• toxic (for example inhalation of  toxic gases)• complication of shock whatever the cause

Page 32: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Typical pulmonary cardiogenic oedema

Page 33: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Hemodynamic pulmonary edemaradiological features

• Alveolar picture• Perihilar predominent• Bilateral but sometimes assymetric• Always with accute dyspnea, cough and 

clear sputum (although sometimes blood in sputum)

• Crepitant rales (“crackles“) at the auscultation

Page 34: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Acute pulmonary oedema :“butterfly wings“ image

Page 35: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Acute pulmonary oedema

After furosemide

Page 36: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Acute pulmonary oedema Note the asymmetry of the image

Page 37: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Asymetric cardiogenic edema

Page 38: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Two exemples of ARDS

Page 39: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Woman, 71/2 months pregnant. Fever and dyspnea with rapid deterioration in few days. No improvement despite

amoxicilline then erythromycin

2008.01.29

Case 1

Page 40: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Worsening at D2 then D3 : lesionnal oedema probably with a viral origin

2008.01.302008.01.31

Page 41: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

F 27 y., fever, dyspnea and diffuse pain with quick onset. No improvment with antibiotherapy - D1 : admission in intensive care unit. Tamiflu treatment

Bronchial and nasopharyngeal sample for H5N1 virus PCR  

Case 2

Page 42: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

D2 : no improvment => Non invasive ventilation - PCR + for H5N1 Typical ARDS 

Page 43: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

D 4 D 8

D4: mecanical ventilation with intra tracheal tube; Note chest tube for left pneumothorax drainage

Progressive  improvement D 8 to D25

Page 44: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

D 12 D 25 

ARDS lesionnal edema during a H5N1 flu in a young womanSlow improvement after management in ICU

Page 45: Radiological syndroms Alveolar syndrome Bronchial syndrome Interstitial syndrome Vascular syndrome Mediastinal Syndrome

Alveolar syndrome

Easy to diagnose :Blurred opacity, heterogeneous, ill-defined, except in contact with a fissure (systematized) non retractile with air bronchogram

Must especially evoke :Localized : Bacterial pneumonia, TB pneumoniaDiffuse : acute pulmonary edema, infection (bacteria, TB, virus, fungus)