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AuthorsC2TN members: Pedro Santos3,* (C2TN contract), Sandra Cabo Verde3 (C2TN contract), Maria Helena Casimiro3 (C2TN contract), Luís M. Ferreira3, Fernanda Margaça3, António Falcão3
Students: Joana Madureira3 (PhD), Alexandra P. Rodrigues3
(PhD) * Email of corresponding author: [email protected]
Research group(s) Collaborations
KeywordsRadiation technologies Biomedical applications
Advanced materials Food safety
Wastewater treatment
Funding
Radiation for Material, Environmental and Heath Sciences Research at IRIS
Thematic StrandAdvanced Materials
Thematic StrandEnvironment & Cultural Heritage
Thematic StrandRadiopharmaceutical Sciences
& Health Physics
Good homogeneity of dose distribution across samples
Reproducibility of irradiation experiments
Broad range of dose rates (up to 1,2 kGy/h)
PRECISA22 – 60Co Irradiator
LINAC – Linear electron accelerator
Ionizing Radiation Facility - IRIS
Beam profile obtained withirradiated FWT-60 radiochromicdosimeters (60 cm from the beamexit; relative absorbed doses)
10 MeV
8‐12 MeV
4 s
10‐150 Hz
Electron beam
Photon beam (tungsten target)
Pulse width
Pulse repetition frequency
1 – simulation lamp2 – electron (pre-scatter)3 – (not used)4 – high energy target (photons)5 – low energy target (photons)
http://c2tn.tecnico.ulisboa.ptRADIATION FOR SCIENCE AND SOCIETY
C2TN/IST acknowledgesFundação para a Ciência e a Tecnologia for
financial support under the projectUID/Multi/04349/2013
Non-thermal post-harvest treatment that controls spoilageand foodborne pathogenic microorganisms withoutsignificantly affecting organoleptic attributes. Someimprovements on bioactive content, such as an increase inantioxidant activity, were observed after irradiation.
Food post-harvest irradiation treatment
Extraction of mushrooms valuable compounds through gamma and electron beam irradiation
Effect on bioactive composition and levelof trapped radicals (EPR spectrometry) of irradiated dried spices
Alternative treatment to increase chestnutsshelf-life without affecting the biochemicalprofile and nutritional value.
Microbial inactivation by ionizing radiation duringstorage time and sensory attributes for cherry tomatoes
Infusions of irradiated dried aromatic plants: higher phenolic content, preservation of antimicrobial properties.
Fiber optics as real-time dosimeters
Radiation induced absorption and recovery in a multimodesílica FOD
Low cost dosimeters for personal dosimetry and radiation processing: • in-vivo and real-time dose delivery monitoring in complex oncologic treatments• real-time insight about radiation exposure and facility safety conditions
Contracts with private sector
Active pharmaceutical ingredients (bulk or formulated):evaluation of gamma radiation as a sterilization method (foreither 15 or 25 kGy) and determination of the compoundsradiation resistance (maximum dose).
Irradiation of photonic components to simulate radiationresistance in outer space environment.
Wastewater treatment
Ionizing radiation applied to agro-industrial wastewaters as a complementary treatment to reduce levels of biorecalcitrantcompounds.
Cork boiling wastewater
Radiation effect on the toxicityand antioxidant activity.
Degradation of model recalcitrant compounds by gammaradiation in different conditions (pH and air/N2O saturatedfor ROS yields) and final stable oxidation productsidentification.
Municipal wastewater
Degradation pathway of gammairradiated aqueous solutions ofclofibric acid, a pharmaceuticallyactive drug metabolite foundpersistent in municipal wastewaters.
Hybrid materials for cultural heritage preservation
Preparation of PDMS based ormosils by ionizing radiation to be used alone or as additives for anefficient preservation of Roman mosaics (Conimbriga) and other stone based ancient structures.Promising biocide activity (fungus) will be improved and enlarged to other target microorganisms.
Enteric Virus inactivation
A 4-log reduction of Human Adenovirus titer in municipalwastewater can be reached by using gamma irradiation at adose of 6 kGy as a single treatment process without addingany chemicals, with the added benefit of increasing the waterquality. But, on fresh fruits this virus presented higherradioresistance.
This technology may be an effective tool to guarantee the reduction of viral pathogensand to contribute to public health and sustainable water supplies.
Further studies will be conducted with electron beam irradiation on virussuspensions to deepen the inactivation patterns of enteric virus by ionizing radiation.
Chitosan-Based Matrices for tissue regenerationSingle step chitosan based 3D matrices preparation and sterilization assisted by -radiation forbiocompatible and biodegradable skin scaffolds.
Cellular viability (Human Fetal Foreskin Fibroblasts):• Cells adhered and proliferated in all irradiated matrices (non cytotoxic)• Low Mw chitosan based matrices and presence of gelatin lead to higher cellular proliferation
CIMO-IPB, Bragança, Portugal
LAQV/DQ/DCR-FCT-UNL, Caparica, Portugal
CQE-IST-UL, Lisboa, Portugal
cE3c-FC-UL, Lisboa, Portugal
CICECO-UA, Aveiro, Portugal
MM&Ruins of Conimbriga, Coimbra, Portugal
1 RS | Radiopharmaceutical Sciences Group2 RPS | Radiation Protection and Safety Group3 REI | Radiation, Elements and Isotopes Group4 NET | Nuclear Engineering and Techniques Group5 QEf | f-element Chemistry Group6 SS | Solid State Group