Ranked One of America’s Top 4 Hospitals

Hands on Training in Assisted Reproductive TechnologyART Trainees 2004 - 2014

Center for Reproductive Medicine

Abu Dhabi

Austria

Bahrain

Brazil

Canada

Chile

China

Colombia

Croatia

Czech Republic

Egypt

Greece

Guyana

Hong Kong

India

Iraq

Israel

Italy

Jamaica

Japan

Jordan

Kazakhstan

Korea

Kosovo

Kuwait

Lebanon

Malaysia

Mexico

Nigeria

Peru

Philippines

Romania

Saudi Arabia

Serbia

Slovak Republic

South Africa

Spain

Syria

Turkey

UAE

USA

Venezuela

· Ce

nter

for R

eproductive Medicine ·

Cleveland Clinic

Training program in Assisted Reproductive Technology (ART)We offer a unique opportunity to learn the latest techniques in this rapidly changing subspecialty at one of the world’s premier ART centers:

• World-class faculty• State-of-the-art training facilities• Personalized hands-on training• Multiple comprehensive training modules• Tremendous satisfaction rates• Trained over 150 alumni from > 20 countries since 2003• Certificate of Training awarded at the end of training

This intensive, 320-hour course is available exclusively to scientists and physicians with specific interest in gynecology, andrology or embryology as well as other health professionals such as embryologists, reproductive biologists and technologists.• In vitro fertilization (IVF)• Intracytoplasmic sperm injection (ICSI)• Gamete cryopreservation• Routine and advanced tests in andrology

2 | Cleveland Clinic Center for Reproductive Medicine

Referral to a Human IVF Clinic may be available to select candidates looking for clinical observation.

• Logistics of running an IVF Lab • Observing IVF/ICSI procedures • Oocyte retrieval • Oocyte assessment • Fertilization check • Embryo assessment • Intrauterine insemination

Located in Cleveland, Ohio, Cleveland Clinic is a nonprofit, multispecialty academic medical center that integrates clinical and hospital care with research and education. Founded in 1921 by four renowned physicians with a vision of providing outstanding patient care based upon the principles of cooperation, compassion and innovation, it is the second largest group practice in the world with 3,000 physicians and scientists practicing and researching in more than 120 medical specialities and more than 1,300 beds.

In addition to the main hospital located near Cleveland’s historic University Circle, the Cleveland Clinic operates nine regional hospitals, a children’s hospital, and 17 family health centers in Ohio, as well as hospitals in Florida, Las Vegas, Canada, and Abu Dhabi, employing more than 43,000 individuals and providing global world class medical care. Last year alone, 5.1 million patients from over 80 countries and all 50 states received their care at the Cleveland Clinic.

The main hospital campus, located near downtown Cleveland, occupies 180 acres and 50 buildings. It includes a hospital, an outpatient clinic, a children’s hospital, cancer institute, eye institute, research institute, a medical school and supporting labs and facilities. To learn more, visit www.clevelandclinic.org.

About Cleveland ClinicLearn from the LeadersThe Center for Reproductive MedicineCleveland Clinic’s Center for Reproductive Medicine was established 22 years ago in 1993 with a three-fold mission: to conduct cutting-edge research into the causes of human reproductive and sexual disorders, to develop new fertility biomarkers and treatment modalities and to train physicians and scientists with a commitment to advancing the understanding of human reproduction, infertility and sexual function.

Learn more about our ART Training Program

ART Trainee

taking Module 5

will receive a

FREE copy of

an ART Book

and more...

Course ContentAssisted Reproduction (IVF and ICSI) - Module 5 (160 hours)Learn basic and advanced techniques in:

IVF • Preparation of media • Oocyte handling and scoring • Conventional IVF • Evaluation of fertilization and pronuclear pattern grading • Embryo selection for transfer • Loading catheter for embryo transfer (ET transfer) • Clinical ovarian stimulation and luteal phase support protocol • Laboratory set up • Safety guidelines for the IVF laboratory • IVF laboratory equipment maintenance • Standard and good practices in the IVF laboratory • Quality management of IVF laboratory

Micromanipulation (ICSI) • Oocyte denudation • Preparation of ICSI dishes • Sperm immobilization • Oocyte injection • Assisted hatching (chemical and laser)

ART • Preparing the oocytes for ICSI • Sperm immobilization

Preimplantation genetic diagnosis • Cleavage and blastocyst stage biopsy • Spreading and tubing of cells • Fixation techniques • Equipment maintenance and safety guidelines

Cryopreservation • Slow freezing of oocytes, cleavage stage embryos and blastocysts • Vitrification • Ovarian tissue cryopreservation

Andrology • Sperm preparation for IVF/ICSI (density gradient, sperm wash, swim-up) • Epididymal/testicular sperm preparation/demonstration • Advanced andrology techniques • Frozen sperm preparation for IUI/IVF/ICSI

Virtual Tour of Facilities

Semenology - Module 1 (40 hours)Gain proficiency in:• Routine semen analysis (WHO, 5th edition)• Sperm morphology (WHO, 4th edition and Kruger strict criteria)• Computer assisted semen analysis (IVOS and SCA)• Viability and leukocyte detection• Antisperm antibody testing• Evaluation of sperm membrane integrity• Quality control and assurance in the Andrology Laboratory• Counseling patients with semen analysis results• Proficiency testing in Andrology

Advanced Sperm Function Tests - Module 2 (32 hours)Gain proficiency in the latest techniques:• Sperm DNA fragmentation test by FACS (TUNEL assay)• MACS technique for selection of non-apoptotic spermatozoa• ROS measurement in semen• Acrosome reaction (spontaneous and induced) by FITC test• TAC measurement in seminal plasma• Identification of apoptotic markers in ejaculated spermatozoa by fluorescence microscopy (Annexin V binding)• Special samples analysis of retrograde ejaculate

Sperm Preparation Techniques - Module 3 (16 hours)Develop skills in sperm preparation for ART:• Preparation of ejaculated sperm for ART: Sperm wash Double density gradient technique Swim-up technique• Retrograde specimen processing techniques• Epididymal/testicular sperm retrieval and preparation

Cleveland Clinic Center for Reproductive Medicine | 3Learn more about our ART Training Program

Edmund Sabanegh, MDChairman, Department of UrologyHead, Section of Male InfertilityProfessor, Lerner College of Medicine

Sajal Gupta, MS, MD, TS (ABB) [MS in Clinical Embryology, Jones Institute]Reproductive SpecialistSupervisor, Andrology CenterAssistant Professor, Lerner College of Medicine

Rakesh Sharma, PhDResearch Coordinator,Center for Reproductive MedicineAssociate Professor, Lerner College of Medicine

Ashok Agarwal, PhD, HCLDDirector, Andrology CenterDirector, Center forReproductive MedicineProfessor, Lerner College of Medicine

Christina Anagnostopoulou, MSClinical EmbryologistIVF Clinic “Embryo ART”Athens, GreeceTestimonial

Israel Maldonado Rosas, MScIVF Lab DirectorIVF Clinic “Ingenes”Mexico City, MexicoTestimonial

Cryopreservation of Male Gametes - Module 4 (8 hours)Learn the proper procedures for freezing human spermatozoa:• Freezing ejaculated and testicular human spermatozoa• Cryopreservation of epididymal and vas deferens aspirates• Safety guidelines for sperm freezing laboratory• Quality control procedures

Vitrification - Module 6 (8 hours)Acquire competency and knowledge of vitrification:• Vitrification set up for routine use in an embryology laboratory• Hands on training in vitrification of oocytes and embryos• Use of different carriers

Quality Management of IVF and Andrology Laboratories -Module 7 (16 hours)Understand how to implement a total quality management and improvement program in your laboratory:• Quality control and assurance• Laboratory regulation, licensing, accreditation• The latest quality management tools

Preparing for Accreditation - Module 8 (16 hours)Learn how to prepare your laboratory or tissue bank for accreditation by the College of American Pathologists (CAP) Reproductive Laboratory Inspection Program• Preparation for each step of the process, inspection and post-inspection• Inspection techniques, quality management, FDA compliance

Training Faculty

AccreditationAccredited for 320 AMA PRA Category 1 CreditsTM

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council on Continuing Medical Education for Category 2 credit.Accredited by the American College of Embryology

Learn More For complete information, application instructions and course fees, visit www.clevelandclinic/org/reproductiveresearchcenter/arttraining.html

Virtual tour of the Center for Reproductive Medicine

Training Methodology1. Training provided by 2 certified, practicing Clinical Embryologists2. Trainers include Andrologists, Reproductive Endocrinologists and other experts in ART3. Fully hands-on, one-on-one laboratory training sessions under the direct guidance of Clinical Embryologists • Training is done using animal models (frozen hamster oocyte and mouse embryos) (Module 5)4. Each training session is customized to the trainee’s • Professional background • Level of skill and competence • Specific training needs • Desired outcomes obtained from attending the ART training course5. Interactive discussion and teaching sessions6. Live lectures and multimedia presentations in small group sessions7. Four state-of-the-art micromanipulators dedicated solely for training purposes (IVF/ICSI)

Note:• Training is offered in a dedicated ART training suite inside a non-clinical research laboratory• There is no patient contact

Trainee Evaluations:Each Trainee is tested at the end of their training for:1. Knowledge: Multiple choice questions on lab techniques linked to each course module2. Practical skills: Tested on specific lab techniques taught during the training3. Verbal communication & comprehension skills: PowerPoint talk on a topic linked to a course module

Registered Trainees Will Receive…1. Course Syllabus with Reading Material and Lab Protocols2. Free Access to the Cleveland Clinic Alumni Library 3. Free Text Book on “Practical Manual of In Vitro Fertilization: Advanced Methods and Novel Devices” edited by Dr. Peter Nagy et al, Springer (worth approx. $225.00)4. WHO Laboratory Manual for the Examination of Human Semen and Sperm-Cervical Mucus Interaction. Fifth Edition (CD)5. Certificate of Training (issued upon successful assessment by the instructor)6. Daily Meal Tickets

Scholarship in Teaching AwardTraining Program in Advanced Reproductive Techniques

The Case Western Reserve School of Medicine Scholarship in Teaching Awards is an annual program designed to recognize faculty contribution to education from the preceding year and promote undergraduate, graduate, and continuing medical education teaching as a scholarly activity.

Teaching approaches considered scholarly are characterized by 1) purposeful planning 2) systematic implementation and 3) reflection and assessment for improvement. The result should be an academic product that is actively shared and that will support the development of a community of teaching scholars.

This award was given out at the Case Medical School Education Retreat on March 12, 2015. CRM’s hands-on ART training program has previously been twice-recognized with this prestigious Scholarship in Teaching Award, in 2013 and again in 2014. Besides the ART Training Program, CRM’s Summer Internship program has also been thrice-recognized with this prestigious Scholarship in Teaching Award, in 2011, 2013 and 2014 respectively.

Certificate of Training Awarded Upon the Successful Completion of the Hands on ART Training

04.2015

The Cleveland Clinic

Let it be known that

SAJAL GUPTA, M.D.Assistant Professor, Department of UrologyAssistant Research CoordinatorCenter for Reproductive Medicine

RAKESH SHARMA, Ph.D. Associate Professor, Department of UrologyCoordinator of ResearchCenter for Reproductive Medicine

ASHOK AGARWAL, Ph.D., HCLDProfessor & DirectorCenter for Reproductive MedicineGlickman Urological Institute

September 8th - 26th, 2014

has receivedHands on Training in Human Assisted Reproduction

Module 5A: IVF/ICSI/Micromanipulationfor 120 hours offered by the Center for Reproductive Medicine, Cleveland Clinic

Center for Reproductive Medicine

· Ce

nter

for R

eproductive Medicine

·

Cleveland Clinic

Beatriz Jimenez Vanegas, MScHouston, Texas

ART Training Certificate Presentation Ceremony, Research Laboratory, September 2013

Meet Our 2014 ART Trainees

Cleveland Clinic Center for Reproductive Medicine Learn more about our ART Training Program

“For me to switch from animal to human ICSI was an important step. Also the

use of vitrification, as animal IVF uses more slow freezing. This course is a plus for me in this learning process and will help me in the future for my PhD.”

Beatriz Jimenez Vanegas, MSc Texas, USA

“Great training lab and patient teachers. Excellent learning

material and friendly staff.”David Guerra, MD, OBGynFlorida, USA

“The experience the Trainers have from previous years are reflected

by their patient teaching.”Avraham Harlev, MDBeer-Sheba, Israel

“Experienced embryologists provided individual training. The ART Course was tailored to specific needs.”Stefan du Plessis, MBA, PhDTygerberg, South Africa

“This was a very helpful hands on training course.”

Heidi Price, RMAFlorida, USA “Hands on

experience and knowledgeable

teachers - everything is wonderful”

Ashlie Sadler, MAFlorida, USA

“The ART training was very valuable and helpful in learning the basics and the latest developments in IVF technologies and to transmit my genetic

knowledge into reproductive medicine.”Sezgin Gunes, PhD

Samsun, Turkey

“Learning the most recent techniquesand sharing of different knowledge

with different co-workers was aneffective aspect of this course.”

Mai Jawad Abdullah Al-Qattan, MBAKuwait City, Kuwait

“Excellent hands-on training.”Efiok Eyo Efiok, MBBCh, FWACSCross River State, Nigeria

“Each Trainee gets an individual Trainer. The Course was

completely custom-made, I could choose the areas where I needed more help. Trainers were very

patient and were willing to teach us all the time. This is

the only program that gives real hands-on training. This program is the best I could think of in any part of the world. Real spoon feeding!”

Arun Muthuvel, MDChennai, India

“There was plenty of time to practise the techniques and discuss

different topics related to the IVF lab with the Course Instructors. Excellent knowledge sharing and transfer.”

Zahraa Alyahaei, DPhil Al Ain, UAE

“Step by step procedure in ICSI and hands-on training that can never be

forgotten. All teaching staff had the patience to teach head to toe within the stipulated period.”Dharmaraj Palanisamy, MS, DNB

Tamil Nadu, India

“The hands-on nature of the course made it a standout way of learning the techniques

of ART from experienced and seasoned Trainers and Organizers.”Abdullahi Abdulwahab-Ahmed, MDSokoto State, Nigeria

“The way the Trainers taught was very efficient. It was such an excellent experience here that I think I can’t find it anywhere else.”Zainab Shilbayeh, MD

Texas, USA

“A theoretical background to all the hands-on activities are provided

in lectures. The hands-on experience is excellent.”Ini Jackson Etukudo, FWACSAkwa Ibom State, Nigeria

Read Additional Evaluations

“The Director and other Departmental Personnel showed personal interest. Excellent teachers in a beautiful

learning environment.”Godwin Akhabhoa, FMCOG, FWACSLagos, Nigeria

“Excellent relationship between Trainers and Trainees. Good practical

demonstration sessions.”Oziga Dada Vincent, MBBS, FWACSDelta State, Nigeria

CRM Staff and Fellows with Dr. Joanna Ellington, Andrology Center, March 2015

Lillian Parzianello, BScBrazil, 2013“I had exclusive attention from the trainers; they were able to explain the procedures because they have many years of experience in their own labs. Training is provided by experts in IVF/Andrology that have published in the best journals. It was great to receive the best and complete textbook on ART, i.e. the ART-Practical Manual of IVF.”

Saranda Murtezaj, BScKosovo, 2013“I enjoyed the many different ways of learning techniques from the trainers - this is different from what I am used to.”

Rifat Morina, PhDKosovo, 2013“The equipment and the possibility to learn new techniques were good. The possibility to get answers for every question regarding the course was perfect.”

Krishnan Kanniah, BSc Malaysia, 2013“There is a systematic training program for each day. The review process every morning about what we learnt the day before – brings about good explanation and discussion. Trainers were willing to answer questions and provide excellent explanation.”

Satya Baalasundaram, MVSc India, 2013“I liked the one to one, hands on experience and having been given more time to learn better. Also the lectures/presentations prior to training were very helpful.”

Kannappan Palaniappan, MDMalaysia, 2013“Personalized guidance in teaching and in lab preparation. A well-structured course; very comprehensive.”

Johnkennedy Anyanwu, PhDTexas, USA, 2013“The one-on-one training was excellent and knowledgeable – I never felt hurried.”

Kristina Staab, BScPennsylvania, USA, 2013“I was able to ask questions at any time and get immediate feedback.”

Jeanne Ricci, MScPennsylvania, USA, 2013“We were taught by different trainers and used different types of media.”

Gözde Köksal, MScTurkey, 2012“Excellent training with lots of opportunity for hands on work.”

Swetha Thumula, MDIndia, 2013“The hands on and one-to-one training is unique. The course is well organized and caters to what you want to learn. The feedback session everyday is excellent and gives you more confidence.”

Rizwan Malik, MDIndiana, USA, 2013“Lectures are excellentand informative. Great course, superb experience. Faculty and staff are very caring. Course was verywell organized.”

Mahipal Singh, PhDAtlanta, USA, 2013“I commend the personal commitment of the staff and I enjoyed the home-like environment in the lab.”

Sridevi Kammela, MDIndia, 2013“Trainers gave personalized commitment that benefited each candidate. Attention was also given to every detail.”

Sreedhar Kammela, MDIndia, 2013“There was strict punctuality throughout the course. I received a thorough update of scientific knowledge and an orientation to research.”

Malathy Shanmugam, MBBS, DGOIndia, 2013“I was taught all about the basics of handling a microscope, micromanipulators, laser optical system etc. I also learnt to do ICSI confidently.”

Read Additional Evaluations

Reem Taha, BScJordan, 2012“The hands on experience for me was the most effective because it provided me with practice and taught new techniques that I had never seen before.”

Shweta Tiwari, MDIndia, 2012“The one on one training for ART was excellent. The trainer taught the steps patiently and provided me with completeunderstanding of the protocols.”

Liliana-Aura Chitu, PhDRomania, 2012“As a result of the training provided at Cleveland Clinic, I was able to masterthe skills and achievedexterity in ART techniques.”

2013

2012

2011Raffaele DinardoItaly, 2011“Everything was amazing, especially the skills and patience of the trainers.”

Marisabel Hernandez, BScVenezuela, 2011“The most effective part for me was the hands on training. The equipment was in perfect condition, the lectures are in tune with the practices and the staff are very helpful. I think I improved exponentially and was able to see my own this progress.”

Bianca Kreuscher, MSBrazil, 2011“The course was extremely important, because Ilearned new things that I can use immediately. The best of all was having the opportunity to relate to important people and make new contacts. It was more than I expected.”

Ten Years of ART Training (2004 - 2014): Feedback by our ART Trainee Alumni

Cleveland Clinic Center for Reproductive Medicine Learn more about our ART Training Program

Helena Malvezzi, MSBrazil, 2011“I learned many new things and had the chance to meet and work with interesting people from all over the world.”

CRM Staff and Fellows with the ART Trainer and Trainees, Research Laboratory, Sept 2012

Mary Robert, MBBS, MD, DGOUnited Arab Emirates, 2004“The impossible being made possible! I benefited immensely from the precise manner by which the techniques were made simple. I am now able to perform the technique independently and with confidence.”

Troy Anhalt, BSWisconsin, USA, 2005“I enjoyed my time here. The staff were wonderful and I am exited to take this information back to my lab.”

Andrea Mustata, MDRomania, 2007“Hands-on-training techniques were very well organized. Very dedicated trainers who were patient and helpful. Excellent ART training.”

Lina Garcia, MTCPPuerto Rico, 2008“The experience was great. Everybody was very professional and willing to help me at all moments. I felt very happy about choosing this program and I will come back if I decide to expand.”

Christopher Danga, BSNigeria, 2009“Hands on training - I was given the opportunity to participate in cell biopsy and fixation, and advanced sperm function tests - everything was NEW!”

Carolina Sellito, PhDItaly, 2010“I would recommend the ART Training at the Cleveland Clinic to anyone who is looking to receive world class, hands on training in ART. The knowledge and friendships that I have brought back to Italy will be of immense significance to me for many years to come.”

Kelly J Porter, HTL (ASCP)New Jersey, USA, 2010“Overall this was a great course with a tremendous amount of material. After spending a week at Cleveland Clinic, I have a much greater understanding of semen analysis and feel confident I will be able to introduce this testing to my facility. This week has also given me a greater sense of appreciation for Andrology in general.”

Pratima Sekhar, MDIndia, 2006 “It was a great experience being in such a huge IVF lab with the best of the infrastructure and technical personnel.”

Canan Aslan, MScTurkey, 2010“Adequate hands on practice helped me master the techniques.”

Desta Gelagay, BS (ASCP)California, USA, 2008“The course has met every expectation that I had made for the class. The class was a ton of fun, but very intellectually challenging at the same time. I was able to learn a great deal of information that will help in my current job. The experience has motivated me to work harder.”

Luis A Murrain Jr, DONew York, USA, 2008“The one to one interaction with the instructors allowed the trainee to focus on the areas they feel they need to work on the most while meeting the course objectives. Helpful critique of technique and common pitfalls to avoid. This is an excellent training course for those seeking to learn new skills or refine their technique. The strong emphasis on research ensures the trainee will be up to date on current literature and treatment protocol.”

Gulnara Utepova, MDKazakhstan, 2009“Friendly staff. New information. Excellent overall course management and facility (is) conducive to learning.”

Amanda Setti, BSBrazil, 2007“I have learned everything I wanted to mainly because of the trainer’s knowledge and patience in teaching.”

Harry Beauvais, MDHaiti, 2007“The accessibility of thetrainers to provide assistance and share their great experience was very valuable.”

Karuna Sharma, MDSaudi Arabia, 2006“The faculty members are very encouraging and they were boosting your morale all the time.”

Samina Naeem Khalid, MDPakistan, 2006“I liked the collaboration of researchers from all over the world – it gave me the opportunity to learn more.”

Chris Agboghoroma, MDNigeria, 2007“Very conducive atmosphere to learning.”

Pamela Herbst, MTFlorida, USA, 2005“This was a refresher course for me, so the hands on time was very valuable.”

Ten Years of ART Training (2004 - 2014): Feedback by our ART Trainee Alumni

Cleveland Clinic Center for Reproductive MedicineLearn more about our ART Training Program

2010

2008

2006

2005

2004

2007

2009

Cleveland Clinic’s Center for Reproductive MedicineHands on Training in Assisted Reproductive TechnologyFor more info, contact Dr. Ashok AgarwalDirector of ART Trainingagarwaa@ccf.org, +1.216.444.9485http://www.clevelandclinic.org/reproductiveresearchcenter/artmain.html

Romil Stanislavov, PhDBulgaria, 2009“The presentation and demonstration of the methods (are) in detail. Appropriate time (given) for discussion and questions.”

CRM Staff and Fellows with ART Trainer and Trainees, Andrology Clinical Laboratory, Sept 2011

Cleveland Clinic’s Glickman Urological and Kidney Institute is recognized worldwide for excellence in patient care, teaching and research. It merges Cleveland Clinic’s urology and nephrology programs. Urology and nephrology physicians and scientists at Cleveland Clinic are recognized worldwide for excellence in patient care, teaching and research. This year, U.S. News & World Report ranked our urology program No. 1 and our kidney disease program No. 2 in the nation. Please visit us at: clevelandclinic.org/services/urology-kidney/about-urology-nephrology

About Cleveland ClinicNinety-two years ago, four physicians founded a new medical center in Cleveland. It was a nonprofit group practice where doctors from many specialties could collaborate for efficiency and better patient care. Their mission was “to care for the sick, investigate their problems and educate those who serve.” Located in Cleveland, Ohio, Cleveland Clinic is a nonprofit, multispecialty academic medical center that integrates clinical and hospital care with research and education. Today, with more than 1,400 beds on Cleveland Clinic main campus and 4,450 beds system-wide, Cleveland Clinic is one of the largest and most respected hospitals in the country. Today, Cleveland Clinic is a main campus, eight community hospitals and more than 75 outpatient locations (including 16 family health centers) in northern Ohio, and facilities in Florida, Nevada, Toronto and Abu Dhabi. Our locations are linked by health information technology and critical care transport, getting patients to the right facility, at the right time, for the right care. Cleveland Clinic is organized into patient-centered institutes based on single diseases or organ systems. Each institute combines medical and surgical services at the same location under the same leadership to improve patient care and experience. Each institute is required to establish benchmarks and measure and improve quality. Institutes are also required to publish annual outcomes books showing volumes, results, innovations, publications and other information relevant to patients and referring physicians. Cleveland Clinic integrates its far-flung system with an extensive electronic medical records system. This system includes participating community physicians and patients, who are able to access test results and portions of their medical record remotely via the Internet. Cleveland Clinic’s model of medicine has made it possible for us to achieve cost savings on a vast scale over the past several years. Our mantra is “Patients First.” Our motto is “To Act as a Unit.” Our goal is to give every patient the best outcome and experience. That’s the Cleveland Clinic way. Visit: clevelandclinic.org