Did you know that the freshwater algae Tetradesmus obliquus uses a strategy to protect itself against UV stress? Once exposed to light, it develops an envelope of carotenoids that acts rather like a Faraday shield and stops radiation getting to it.

Likewise, the skin needs to safeguard itself against various types of radiation such as UV, HEV and WiFi that can induce a damaging cascade effect. Initially, ROS are generated, followed by impairment of proteins, DNA and lipids on a cellular level that leads to subsequent weakening of the skin barrier and eventually premature skin ageing.

RADICARE®-GOLD Your Personal Faraday Shield

RADICARE®-GOLD reproduces the protective concept employed by Tetradesmus obliquus and can be applied to the skin to provide it with a “Faraday shield” to screen it from radiation. Natural carotenoids have a dual effect on skin cells and barrier: as they activate PPARγ, they both defend skin cells against the effects of ROS and inhibit lipid peroxidation. Further more, the product replenishes the carotenoid depot of the skin barrier and provides a more juvenile appearance of the skin. So, put on your personal Faraday shield to help your skin resist intrinsic ROS stress and the stress caused by radiation from the natural and more recent digital sources – such as blue light and even WiFi.

MODE OF ACTION

Carotenoids from Tetradesmus obliquusThis algae develops an envelope of carotenoids, when exposed to light. It acts like a Faray shild protecting the algae from harmful radiation. Those carotenoids also protect the skin barrier and cells from ROS-generated damage.

Artificial HEV light can excite photosensitisers like flavins, lipofuscin and advanced glycation end products which transfer their energy to generate ROS. Stress and radiation can increase the number of electrons leaking from the respiratory chain by interfering with the mitochondrial metabolism or simply as result of tissue warming. The carotenoids β–carotene and lutein can relax excited molecules and scavenge ROS at an early stage. Stimulation of catalase increases the degradation of hydrogen peroxide.

SCIENTIFICALLY PROVEN EFFECTS• Absorbs high-energy visible light (in-vitro study)• Activates cells’ oxidative stress defence system

(in-vitro study) • Alleviates cellular oxidative stress (in-vitro study)• Reduces blue light-induced oxidative stress (in-vitro study)• Reduces WiFi-induced oxidative stress (in-vitro study)• Protects cells against lipid peroxidation (in-vitro study)• Stimulates the epidermis (in-vitro study)• Attenuates the skin’s carotenoid loss in summer

(in-vivo study)• Reduces lipid peroxidation and strengthens

the skin barrier (in-vivo study)• Increases skin hydration and decelerates skin ageing

(in-vivo study)

ACTIVE INGREDIENTS

ß-carotene (2)

HO

H OH

Lutein (1)

Intracellular generation of ROS leads to a cascade of events. Starting with super-oxide, highly reactive radicals emerge which destroy the antioxidant shield of the skin barrier and cells leading to sub-stantial damage. The result is premature skin ageing.

Skin ageing

Skin barrier damage

Lipid peroxidation

Cell damage

Anti-oxidants depletion

H2O2

·OH

Radiation(extrinsic)

Respiration (intrinsic)

O2.-

ROS-EliminationMaintenance of proteins, DNA and lipids

PPARγ

Mitochondria/ Respiratory chain

ROS

Mitochondria/ Respiratory chain

Leak elektronse-Leak elektronse-

Catalase

STOP

β-caroteneLutein

STOP

LipofusinAGE

STOP

DNA damage Lipid damage Protein damage

ROSβ-carotene

Lutein

β-caroteneLutein

(Artificial)Blue light

UVStress Radiation

WiFiStress Radiation

WiFi

(Artificial)Blue light

UV

LipofusinAGE

Anti-Ageing products, protection products, lifestyle products, sun formulations

Recommended Use Level: 1 – 5 %

Application and Processing Information INCI: EU: Crambe Abyssinica Seed Oil, Beta-Carotene, Xantho-phylls, Tocopherol, Helianthus Annuus Seed Oil, Rosmarinus Officinalis Leaf Extract PCPC / Japan: Crambe Abyssinica Seed Oil, Beta-Carotene, Xanthophylls, Tocopherol, Helianthus Annuus (Sunflower) Seed Oil, Rosmarinus Officinalis (Rosemary) Leaf Extract co

mpliant

NAGOYA

comp

liant

CHINA

listed

COSMOS

REDUCES WIFI-INDUCED OXIDATIVE STRESS (in-vitro study)

Method: Intracellular ROS content with subconfluent, prolifera-ting keratinocytes with were placed on a WiFi emitter.

Implementation: HaCaT-cells with 0.5 % DMSO and 0.005 % T. obliquus carotenoids were exposed to WiFi radiation with 0, 0.5 and 50 mW for 5 hours.

Result: Internal ROS were quenched significantly by 10.9 % without radiation (WiFi off). On exposure to a WiFi field, the generation of ROS increased with field intensity by up to +25 % at 50 mW. RADICARE®-GOLD reduced this extra ROS load by more than 70 %.

ATTENUATES THE SKIN‘S CAROTENOID LOSS IN SUMMER (in-vivo study)

Method: Carotenoid content in the skin were measured with Multiple Spatially Resolved Reflection Spectroscopy. The reflec-ted and fluorescent light from these sites is detected.

Implementation: 15 female and 9 male subjects; 21 – 56 years old, inner side of forearms, twice daily application of emulsion with 5 % RADICARE®-GOLD and placebo (0 % RADICARE®-GOLD), after 61 – 64 days assessment via MSRRS.

Result: At the thenar (control), an only marginal carotenoid depletion was observed. In contrast, during summer, the fore-arm skin lost more than 20 % of carotenoids. Treatment with 5 % RADICARE®-GOLD significantly reduced this loss in compa-rison with placebo.

REDUCES LIPID PEROXIDATION AND STREGTHENS THE SKIN BARRIER (in-vivo study)

Method: Collected corneocytes were used with the Lipid Peroxi-dation (MDA) Assay Kit.Corneocytes were detached from the face with Corneofix® F20 desquamation collector foil.

Implementation: 20 female subjects; 20 – 46 years old, hemiface, twice daily application of emulsion with 3 % RADICARE®-GOLD and placebo (0 % RADICARE®-GOLD), after 28 days assessment with MDA assay Kit and Tapestripping (Corneofix F20).

Result:Lipid Peroxidation: RADICARE®-GOLD-treated skin exhibited a reduction in lipid peroxidation by 37%.

ROS generation in keratinocytes exposed to WiFi field

% from baseline (vehicle control WiFi off)

Vehicle controlT. obliquus carotenoids 0.005%

Mean + SEM;n = 12;

* = p < 0.05 ** = p < 0.01*** = p < 0.001

40

30

20

10

0

-10

-20

-71% ***

-73% ***

*

*

***

**

WiFi off WiFi 0.5 mW WiFi 50 mW

Reduction of carotenoid content

Relative to initial condition (%) Control Placebo RADICARE®-GOLD 5%

Mean + SEM; n = 24;

* = p < 0.05 *** = p < 0.001

***

*

0

-5

-10

-15

-20

-25

-30

Increase in barrier strength

Relative to initial condition (%)

Mean + SEM; n = 20;

* = p < 0.05*** = p < 0.001

PlaceboRADICARE®-GOLD 3%

100

75

50

25

0

****

p = 0.2

WiFi emitter system within a Faraday cage

DISCLAIMERUtilisation of this document or parts thereof as well as product names for commercial or industrial applications is subject to explicit written approval by RAHN AG. This information is based on our own experience to date and we believe it to be reliable. It is intended only as a guide to use at your discretion and risk. We cannot guarantee favourable results and assume no liability in connection with its use, or the use of the methods or products described. None of this information is to be taken as a license to operate under, or a recommendation to infringe patents.

Version: 2/2019

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