Quick Reference Table Conclusion**** Citation † …...2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530, 1992 2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail

Quick Reference TableReview

Conclusion****Explanation Journal

Citation †Ingredient Name or Group Name S SQ I Z U UNS Use concentration

for S conclusionConcentration or

other limitation onuse for SQ conclusion

Safety concern for Uor UNS conclusion

1,2-butanediol 1 not in use at the time* IJT 31(S2): 147-168,2012

1,2-hexanediol 1 0.00005 to 10% IJT 31 (S2): 147-168,2012

1-Hydroxyethyl 4,5-Diamino Pyrazole Sulfate 1 safe as an oxidative hair dye Final report 03/2016available from CIR

1-Naphthol 1 up to 3% in haircoloring products

JACT 8(4):749-68,1989 confirmed

12/062,3-Naphthalenediol 1 JACT 7(3):353-57,

19882,4-Diaminophenol 1 0.2% as the free base JACT 13(5):330-43,

1994 confirmed06/09

2,4-Diaminophenol HCl (aka 2,4-DiaminophenolDihydrochloride)

1 0.2% as the free base JACT 13(5):330-43,1994 confirmed

06/092,4-Diaminophenoxyethanol HCl 1 up to 2% Final Amended

Report 12/07Available from CIRJACT 10(1):113-34,

1991 (original report)2,4-Diaminophenoxyethanol Sulfate (amended) 1 up to 2% Final Amended


1991 (original report)2-Amino-3-Hydroxypyridine 1 Final report 09/2014

available from CIR2-Amino-3-Nitrophenol 1 up to 2% in hair dyes IJT 28(S3): 217-251,

20092-amino-4-hydroxyethylaminoanisole 1 should not be used in cosmetic

products where N-nitrosocompounds may be formed

IJT 32(S1):25-35,2013

2-amino-4-hydroxyethylaminoanisole sulfate 1 should not be used in cosmeticproducts where N-nitroso

compounds may be formed

IJT 32(S1):25-35,2013

2-Amino-4-Nitrophenol 1 concentration not reported * IJT 28(S3): 217-251,2009

2-Amino-4-Nitrophenol Sulfate 1 not in current use * IJT 28(S3): 217-251,2009

2-Amino-5-Nitrophenol 1 not in current use * IJT 28(S3): 217-251,2009

2-Amino-6-Chloro-4-Nitrophenol 1 up to 2% in hair dyes IJT16(S1):131-43,1997

2-Amino-6-Chloro-4-Nitrophenol HCl 1 up to 2% in hair dyes IJT16(S1):131-43,1997







2-Bromo-2-Nitropropane-1,3-Diol 1 0.1%; may contribute toendogenous nitrosamine

formation; but should not beused under circumstances

where its actions withamines or amides can

result in the formation ofnitrosamines or nitrosamides

JACT 3(3):139-55,1984 (Addendum)JEPT 4(4):47-61,

1980 (Originalreport) confirmed09/03 IJT 25(S2),

2006

2-Chloro-p-Phenylenediamine 1 up to 0.1% JACT 11(4):521-530,1992

2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530,1992

2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing

this ingredient should beaccompanied with directions

to avoid skin contactbecause of the sensitizingpotential of methacrylates

IJT 24(S5):53-100,2005

2-Methyl-5-Hydroxyethylaminophenol 1 up to 5% JACT 9(2):185-202,1990 confirmed

08/062-Methyl Resorcinol 1 up to 2% JACT 5(3):167-

203, 1986 confirmed12/06

2-Nitro-p-Phenylenediamine 1 up to 1% JACT 4 (3):161-202,1985 confirmed

11/03 IJT 25(S2),2006

2-oleamido-1,3-octadecanediol 1 safe as used Final report 03/2015available from CIR

3-Methylamino-4-Nitrophenoxyethanol 1 up to 0.15% IJT 27 (S2): 41-51,2008

3-Nitro-p-Hydroxyethylaminophenol 1 up to 10% in hair coloringproducts (5% after dilution)

IJT 28(S3): 217-251,2009

4-Amino-2-Hydroxytoluene 1 up to 5% JACT 8 (4):569-87,1989 confirmed

04/064-Amino-2-Nitrophenol 1 IJT 28(S3): 217-251,

20094-Amino-3-Nitrophenol 1 up to 9% in hair dyes IJT 28(S3): 217-251,

20094-Amino-m-Cresol 1 up to 0.7% in oxidative and

non-oxidative hair dyesIJT 23(S2):1-22,

20044-Chloro-2-Aminophenol 1 1 Safe ase used in oxidative

hair dyes, but the availabledata are insufficient to

IJT 23(S2):1-22,2004







support the safety innon-oxidative hair dyes

4-Chlororesorcinol 1 1% in hair dyes JACT 15 (4): 284-94,1996

4-Hydroxypropylamino-3-Nitrophenol 1 up to 2.6% in hair dyes IJT 28(S3): 217-251,2009

4-Methoxy-m- Phenylenediamine 1 carcinogenicity JACT 11(4):381-422,1992

4-Methoxy-m-Phenylenediamine HCl 1 carcinogenicity JACT 11(4):381-422,1992

4-Methoxy-m-Phenylenediamine Sulfate 1 carcinogenicity JACT 11(4):381-422,1992

4-Nitro-m-Phenylenediamine 1 up to 0.2% JACT 4 (3):161-202,1985 confirmed

11/03 IJT 25(S2),2006

5-Amino-4-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes

IJT 23(S2):1-22,2004

5-Amino-6-Chloro-o-Cresol 1 up to 2% in oxidative andnon-oxidative hair dyes

IJT 23(S2):1-22,2004

5-Bromo-5-Nitro-1,3-Dioxane 1 0.1%; but should not be usedunder circumstances where itsactions with amines or amidescan result in the formation ofnitrosamines or nitrosamides

JACT 9(2):279-88,1990

6-Amino-m-Cresol 1 up to 2.4% in oxidative andnon-oxidative hair dyes

IJT 23(S2):1-22,2004

6-Amino-o-Cresol 1 Safe as used (up to 0.7%) inoxidative hair dyes, but the

available data are insufficientto support the safety innon-oxidative hair dyes

IJT 23(S2):1-22,2004

6-Hydroxyindole 1 IJT 33(S3):24-35,2014

Acacia Catechu Gum 1 IJT 24(S3):75-118,2005

Acacia Concinna Fruit Extract 1 IJT 24(S3):75-118,2005

Acacia Dealbata Leaf Extract 1 IJT 24(S3):75-118,2005

Acacia Dealbata Leaf Wax 1 IJT 24(S3):75-118,2005

Acacia Decurrens Extract 1 IJT 24(S3):75-118,2005

Acacia Farnesiana Flower/Stem Extract 1 IJT 24 (S3):75-118,2005

Acacia Farnesiana Flower Wax 1 IJT 24(S3):75-118,2005







Acacia Farnesiana Gum 1 IJT 24(S3):75-118,2005

Acacia Senegal Extract 1 IJT 24(S3):75-118,2005

Acacia Senegal Gum 1 up to 9% for the gum and0.001% for the extract

IJT 24(S3:75-118,2005

Acacia Senegal Gum Extract 1 up to 9% for the gum and0.001% for the extract

IJT 24(S3:75-118,2005

Acetamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should

not be used in cosmeticproducts in which N-nitrosocompounds may be formed

IJT 34(S1): 18-34,2015; JACT

12(3):225-36, 1993(original report); IJT30(S2):73-127, 2011

(re-review)

Acetic Acid 1 0.0003 to 0.3% IJT 31(S4): 112- 136,2012

Acetyl arginine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

Final report 12/2013available from CIR

Acetylated Lanolin 1 up to 7% JEPT 4(4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Acetylated Lanolin Alcohol 1 up to 16% JEPT 4 (4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Acetyl Carnitine 1 safe when formulatedto be non- irritating

IJT 31(S3):296-341,2012

Acetyl Carnitine HCl 1 safe when formulatedto be non- irritating

IJT 31(S3):296-341,2012

Acetyl Cysteine 1 safe for use in cosmetics whenformulated to be non-irritating


Acetyl Glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Acetyl Glutamine 1 safe for use in cosmetics whenformulated to be non-irritating


Acetyl Histidine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Acetyl Methionine 1 safe for use in cosmetics whenformulated to be non-irritating


Acetyl Proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Acetyl Tributyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002

Acetyl Triethyl Citrate 1 up to 7% IJT 21 (S2):1-17,2002







Acetyl Trihexyl Citrate 1 not in current use * IJT 21(S2):1-17,2002

Acetyl Trioctyl Citrate 1 not in current use * IJT 21(S2):1-17,2002

Acetyl Tyrosine 1 safe for use for cosmeticswhen formulated

to be non-irritating


Achillea Millefolium Extract 1 safe for use when formulatedto be non-sensitizing

IJT 20(S2):79-84,2001; final report12/2013 available

from CIRAchillea Millefolium Flower/Leaf/Stem Extract 1 safe for use when formulated

to be non-sensitizingFinal report 12/2013

available from CIRAchillea Millefolium Flower Extract 1 safe for use when formulated

to be non-sensitizingFinal report 12/2013

available from CIRAcid Orange 3 1 0.2% in hair dyes IJT 19 (S1):1-9, 2000Acid Violet 43 1 safe for use in hair dye

formulations when free ofimpurities except for the

following: less than or equalto 18% volatile matter (at 135degrees C) and chlorides andsulfates (calculated as sodium

salts); less than or equal to0.4% water-insoluble mat

IJT 20(S3):1-6, 2001

Acrylamide/Ethyltrimonium Chloride* Acrylate/Ethalkonium Chloride Acrylate Copolymer

1 safe in the present practices ofuse and concentration, when

formulated to be non-irritating

IJT 31(S3): 296-341(2012)

Acrylamidopropyl Trimonium Chloride/AcrylamideCopolymer*



IJT 31(S3): 296-341(2012)

Acrylamidopropyl-Trimonium Chloride/AcrylatesCopolymer



IJT 31(S3): 296-341(2012)

Acrylates/Ammonium Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/bis-hydroxypropyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Acrylates/C12-13 Alkyl Methacrylates/MethoxyethylAcrylate Crosspolymer

1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Acrylates/dimethiconol acrylate copolymer 1 up to 0.5% Final report 12/10available from CIR

Acrylates/Ethylhexyl Acrylate/Glycidyl MethacrylateCrosspolymer



Acrylates/Ethylhexyl Acrylate/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR







Acrylates/Ethylhexyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Acrylates/Hydroxyesters Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/PEG-4 Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Acrylates/PVP Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/Steareth-20 Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/Steareth-20 Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Acrylates/Steareth-50 Acrylate Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/VA Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Acrylates/Vinyl Neodecanoate Crosspolymer 1 Final report 11/2011available from CIR

Acrylates C10/30 Alkyl Acrylate Crosspolymer 1 1 when used as describedin assessment, 0.0002-5%

data does not support usewhen polymerized in benzene


Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Acrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Actinidia Chinensis (Kiwi) Seed Oil 1 up to 0.1% Final report 03/11available from CIR

Adansonia Digitata Oil 1 up to 0.01% Final report 03/11available from CIR

Adansonia Digitata Seed Oil 1 not in current use* Final report 03/11available from CIR

Adansonia digitata seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Adipic Acid 1 0.000001% in leave-on; 18% in rinse- off

IJT 31 (S1):5-76,2012

Adipic acid/1,4 butanediol/terephthalate copolymer 1 not in current use* IJT 33(S3):36-47,2014

Adipic Acid Dihydrazide 1 JACT 13(3):154-6,1994

Agar 1 Final report 09/2015available from CIR







Agarose 1 Final report 09/2015available from CIR

Alanine 1 3.0 x 10-7 to 0.1% IJT 32(S4):41-64,2013

Alcaligenes polysaccharides 1 0.005 to 0.3% Final report 09/12available from CIR

Alcohol Denat. denatured with Quassin or Brucine 1 IJT 27 (S1):1-43,2008

Alcohol Denat. denatured with t-Butyl Alcohol, DenatoniumBenzoate, Diethyl Phthalate, or Methyl Alcohol

1 up to 99% IJT 27 (S1):1-43,2008

Aldioxa 1 JACT 12(3):237-42,1993

Aleurites Moluccanus Bakoly Seed Oil 1 not in current use* Final report 03/11available from CIR

Aleurites Moluccanus Seed Oil 1 0.00001 to 5% Final report 03/11available from CIR

Algae Exopolysaccharides 1 Final report 09/2015available from CIR

Algin 1 Final report 09/2015available from CIR

Alginic Acid 1 Final report 09/2015available from CIR

Alkyl aryl sulfonate hydrotropes 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 30(Suppl.3):270-283, 2011

Allantoin 1 up to 2% IJT 29(Suppl. 2):84-97, 2010

Allantoin Ascorbate 1 up to 0.05% IJT 29(Suppl. 2):84-97, 2010

Allantoin Biotin 1 not in current use * IJT 29(Suppl. 2):84-97, 2010

Allantoin Galacturonic Acid 1 not in current use * IJT 29(Suppl. 2):84-97, 2010

Allantoin Glycyrrhetinic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010

Allantoin Panthenol 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010

Allantoin Polygalacturonic Acid 1 concentration not reported * IJT 29(Suppl. 2):84-97, 2010

Allyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Allyl Methacrylates Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Almondamide DEA 1 safe in the present practices ofuse and concentration when


IJT 32(S1):36-58,2013







and when the levels of freeDEA do not exceed those

considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products

Almondamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,

which may be based on aquantitative risk assessment

IJT 31(S1):77-111,2012

Almondamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,



Almond oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Almond oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Almond Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating


Aloe Andongensis Extract 1 IJT 26(S2):1-50,2007

Aloe Andongensis Leaf Juice 1 IJT 26(S2):1-50,2007

Aloe Arborescens Leaf Extract 1 IJT 26(S2):1-50,2007

Aloe Arborescens Leaf Juice 1 IJT 26(S2):1-50,2007

Aloe Arborescens Leaf Protoplasts 1 IJT 26(S2):1- 50,2007

Aloe Barbadensis Flower Extract 1 safe as cosmetic ingredientsin the practices of useand concentrations as

described in this safetyassessment, if anthraquinone

levels in the ingredientsdo not exceed 50 ppm.

IJT 26(S2):1-50,2007

Aloe Barbadensis Leaf 1 safe as cosmetic ingredientsin the practices of useand concentrations as



IJT 26(S2):1- 50,2007

Aloe Barbadensis Leaf Extract 1 safe as cosmetic ingredientsin the practices of use

IJT 26(S2):1-50,2007







and concentrations asdescribed in this safety

assessment, if anthraquinonelevels in the ingredientsdo not exceed 50 ppm.

Aloe Barbadensis Leaf Juice 1 safe as cosmetic ingredientsin the practices of useand concentrations as



IJT 26(S2):1-50,2007

Aloe Barbadensis Leaf Water 1 safe as cosmetic ingredientsin the practices of useand concentrations as



IJT 26(S2):1-50,2007

Aloe Barbadensis Polysaccharides 1 safe as cosmetic ingredientsin the practices of useand concentrations as



IJT 26(S2):1-50,2007

Aloe Ferox Leaf Extract 1 IJT 26(S2):1-50,2007

Aloe Ferox Leaf Juice 1 IJT 26(S2):1-50,2007

Aloe Ferox Leaf Juice Extract 1 IJT 26(S2):1-50,2007

Alpha Hydroxy Acids (e.g. Glycolic and Lactic Acid, andtheir salts and esters) (see CIR report of the same name)

Glycolic and Lactic Acid,their common salts and their

simple esters, are safe foruse in cosmetic products

at concentrations less thanor equal to10%, at finalformulation pH greater

than or equal to3.5, whenformulated to avoid increasing

sun sensitivity or whendirections for use include

IJT 17(S1):1-242,1998

Alumina 1 Final report 12/2013available from CIR

Alumina Magnesium Metasilicate 1 up to 0.01% Final Report 09/09available from CIR







Aluminum Calcium Sodium Silicate 1 up to 6% Final Report 09/09available from CIR

Aluminum Citrate 1 concentration not reported * IJT 33 (S2): 16-46,2014

Aluminum Dimyristate (amended) 1 up to 3% IJT29(S3) :162-186,2010

Aluminum Distearate 1 up to 5% JACT 1(2):143-77, 1982 confirmed

11/01 IJT22(S1):1-35, 2003

Aluminum Hydroxide 1 Final report 12/2013available from CIR

Aluminum Iron Silicates 1 not in current use* Final Report 09/09available from CIR

Aluminum Isostearates/Myristates 1 not in current use * IJT29(S3) :162-186,2010

Aluminum Myristate 1 up to 1% IJT 29(S3) :162-186,2010

Aluminum Myristates/Palmitates 1 up to 6% IJT29(S3) :162-186,2010

Aluminum Silicate 1 up to 37% in dentifrices;up to 3% in other uses

IJT 22(S1):37-102,2003

Aluminum Starch Octenylsuccinate 1 safe as used provided thatestablished limitations

imposed on heavymetal concentrations

are not exceeded

IJT 21(S1):1-7, 2002

Aluminum Stearate 1 up to 8% JACT 1(2):143-77,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Aluminum Tristearate 1 up to 10% JACT 1(2):143 -77,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Amaranthus Hypochondriacus Seed Oil 1 not in current use* Final report 03/11available from CIR

Amino Bispropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003

Aminoethyl Propanediol 1 Final report 09/2013available from CIR

Aminomethyl Propanediol (amended) 1 up to 2% IJT 28 (S2):141-1612009 JACT

9(2):203-28, 1990(original report);

final report 09/2013available from CIR







Aminomethyl Propanol (amended) 1 up to 7% IJT 28 (S2):141-1612009 JACT

9(2):203-28, 1990(original report)

Aminopropyl Dimethicone 1 not in current use * IJT 22(S2):11-35,2003

Ammonium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Ammonium Alginate 1 Final report 09/2015available from CIR

Ammonium Bisulfite 1 up to 32% IJT 22(S2):63- 88,2003

Ammonium C12-15 Pareth Sulfate 1 safe in the present practices ofuse and concentration when


IJT 29(Suppl.3) :151-161,2010

Ammonium Capryleth Sulfate, 1 safe in the present practices ofuse and concentration when


IJT 29(Suppl.3) :151-161,2010

Ammonium Cocomonoglyceride Sulfate (amended) 1 not in current use * IJT 30(S1):5S-16SAmmonium Coco-Sulfate 1 not in current use * IJT 29(S2): 115-132,

2010Ammonium Cocoyl Isethionate 1 safe for use in cosmetics when

formulated to be non-irritatingFinal report 09/2013

available from CIRAmmonium Cocoyl Sarcosinate 1 safe as used in rinse-off

products; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products

where these ingredientsare likely to be inhaled.

IJT 20(S1):1-14,2001

Ammonium Cumenesulfonate 1 not in current use * IJT 30(S3):270-283,2011

Ammonium Dinonyl Sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Ammonium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Ammonium Glycolate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH

greater than or equal to3.5,when formulated to avoidincreasing sun sensitivityor when directions for use

include the daily use of sun

IJT 17(S1):1-242,1998







protection. These ingredientsare safe for use in sal

Ammonium Glycyrrhizate 1 up to 5% IJT 26 (S2):79-112,2007

Ammonium Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH


include the daily use of sunprotection. These ingredients

are safe for use in sal

IJT 17(S1):1-242,1998

Ammonium Laureth Sulfate 1 safe in the present practices ofuse and concentration when



11/02 IJT24(S1):85-89,

2005; IJT 29(Suppl.3) :151-161,2010

Ammonium Lauroyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Ammonium Lauryl Sulfate 1 safe for use in rinse-offproducts; but 1% for leave-on


06/02 IJT24(S1):89-98, 2005

Ammonium Myreth Sulfate 1 not in current use * safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Ammonium Myristyl Sulfate 1 not in current use * IJT 29(S2): 115-132,2010

Ammonium Persulfate 1 safe as oxidizing agentsin hair colorants and

lighteners designed forbrief, discontinuous usefollowed by thorough

rinsing from hair and skin

IJT 20(S3):7-21,2001

Ammonium Phosphatidyl Rapeseedate* 1 safe as used Final report 03/2015available from CIR







Ammonium Polyacrylate 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Ammonium Stearate 1 up to 10% JACT 1(2):143-77,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Ammonium Styrene/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Ammonium Sulfite 1 not in current use * IJT 22 (S2):63-88,2003

Ammonium Tallate 1 not in current use * IJT 28(S3):252-258,2009

Ammonium Thioglycolate (amended) 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes

and colors; safe at 15.2%(as thioglycolic acid);

hairdressers should avoidskin contact and minimizeconsumer skin exposure

IJT 28(S3):68-133,2009 JACT


Ammonium VA/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Ammonium Xylenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011

Amodimethicone 1 up to 3% IJT 22(S2):11-35,2003

Amodimethicone Hydroxystearate 1 not in current use * IJT 22(S2):11-35,2003

AMP-Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Amyl Acetate 1 up to 10% JACT 7(6):705-19,1988

Amyl Benzoate 1 not in current use * IJT 31 (S3):342-372(2012)

Amylodextrin 1 Final report 09/2015available from CIR

Amylopectin 1 Final report 09/2015available from CIR

Amylose 1 Final report 09/2015available from CIR

Anacardium Occidentale (Cashew) Seed Oil 1 0.002 to 1% Final report 03/11available from CIR

Anthemis nobilis flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing








Anthemis nobilis flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Anthemis nobilis flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Anthemis nobilis flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Aphanothece Sacrum Polysaccharide 1 Final report 09/2015available from CIR

Apricotamide DEA 1 safe in the present practices ofuse and concentration when

formulated to be non-irritatingand when the levels of freeDEA do not exceed those

considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product

IJT 32(S1):36-58,2013

Apricotamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,


IJT 31(S1):77-111,2012

Apricot Kernel Amino Acids 1 not in current use * IJT 33(S4):5-12,2014

Apricot Kernel Oil PEG-40 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014

Apricot Kernel Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating


Arabinoxylan 1 Final report 09/2015available from CIR

Arachideth-20 1 safe in cosmetics as longas they are formulated


IJT 31(S2):169-244(2012)

Arachidonic Acid 1 JACT 12(5):481-559,1993

Arachidyl behenate 1 safe for use in cosmetics whenformulated to be non-irritating


arachidyl erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating








Arachidyl Glucoside 1 safe in cosmeticswhen formulated

to be non- irritating

IJT 32 (S3): 22-48,2013

Arachidyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Arachidyl Propionate 1 up to 10% safe in cosmetics as longas they are formulated



06/06; Final report03/2013 available

from CIRArctium Lappa Seed Oil 1 not in use at the time* Final report 03/11

available from CIRArgania Spinosa Kernel Oil 1 0.001 to 10% Final report 03/11

available from CIRArgan oil PEG-8 esters 1 safe for use in cosmetics when

formulated to be non-irritatingIJT 33(S4):13-39,

2014Arginine 1 0.00002 to 18% IJT 32(S4):41-64,

2013Arginine HCl 1 0.004 to 0.02% IJT 32(S4):41-64,

2013Arnica Montana 1 IJT 20(S2):1-11,

2001Arnica Montana Extract 1 IJT 20(S2):1-11,

2001Ascorbyl Dipalmitate 1 not in current use * IJT 18(S3):1-26,

1999Ascorbyl Palmitate 1 up to 0.2% IJT 18(S3):1- 26,

1999Ascorbyl Stearate 1 not in current use * IJT 18(S3):1-26,

1999Ascorbyl tocopheryl acetate 1 not in current use * Final report 03/2014

available from CIRAscorbyl tocopheryl maleate 1 Final report 03/2014

available from CIRAsparagine 1 concentration not reported IJT 32(S4):41-64,

2013Aspartic Acid 1 0.000005 to 1% IJT 32(S4):41-64,

2013Astragalus Gummifer Gum 1 JACT 6(1):1-22,

1987 confirmed09/04; Final report09/2015 available

from CIRAstrocaryum Murumuru Seed Butter 1 0.001 to 7% Final report 03/11

available from CIRAttapulgite 1 up to 8% IJT 22(S1):37-102,

2003







Avena Sativa (oat) bran 1 safe when formulatedto be non-sensitizing


Avena Sativa (oat) bran extract 1 safe when formulatedto be non-sensitizing


Avena Sativa (oat) Flower/leaf/stem Juice* 1 safe when formulatedto be non-sensitizing


Avena Sativa (oat) Kernel Extract 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Kernel Flour 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Kernel Meal 1 safe when formulatedto be non- sensitizing


Avena Sativa (Oat) Kernel Oil 1 0.01 to 3% Final report 03/11available from CIR

Avena Sativa (oat) Kernel Protein 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Leaf/stalk Extract* 1 safe when formulatedto be non-sensitizing


Avena Sativa (oat) Leaf/stem Extract* 1 safe when formulatedto be non-sensitizing


Avena Sativa (oat) Leaf Extract 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Meal Extract 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Meristem Cell Extract 1 Final report 12/2014available from CIR

Avena Sativa (oat) Peptide 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Protein Extract 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Seed Extract* 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Seed Water* 1 safe when formulatedto be non- sensitizing


Avena Sativa (oat) Sprout Oil* 1 safe when formulatedto be non- sensitizing


Avena Sativa (Oat) Starch 1 Final report 09/2015available from CIR

Avena Sativa (oat) Straw Extract 1 safe when formulatedto be non- sensitizing


Avocadamide DEA 1 safe in the present practices ofuse and concentration when


considered safe int the CIRsafety assessment of DEA

IJT 32(S1):36-58,2013







and its salts; should not beused in cosmetic products

Avocadamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,


IJT 31(S1):77-111,2012

Avocadamidopropyl dimethylamine 1 not in current use * safe in cosmetics as longas they are formulatedto be non-sensitizing,



Avocado Oil 1 0.0001 to 98% JEPT 4(4):93-103,1980 confirmed

06/01 IJT22(S1):1-35, 2003

Avocado oil PEG-11 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Avocado oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Avocado Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating


Azelaic acid 1 up to 0.3% in leave-on;up to 10% in rinse- off

IJT 31 (S1):5-76,2012

Azelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Azulene 1 IJT 18(S3):27-32,1999

Babassu Acid 1 not in current use* Final report 03/11available from CIR

Babassuamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Babassuamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)

IJT 34(S1): 18-34,2015







when formulated to benon-irritating; should


Babassuamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,


IJT 31(S1):77-111,2012

Babussuamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,



Barium Sulfate 1 safe in cosmetics as longas they are formulated



Basic Blue 99 1 up to 2% IJT 26(S2):51-63,2007

Basic Violet 1 1 IJT 28(S3):193-204.2009



Bassia Butyracea Seed Butter 1 not in current use* Final report 03/11available from CIR

Bassia Latifolia Seed Butter 1 0.001 to 2% Final report 03/11available from CIR

Batyl Alcohol 1 0.03 to 3% IJT 32 (S3): 5-21,2013

Batyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Batyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Beeswax 1 up to 56% JACT 3(3):1-41,1984 confirmed

06/03 IJT24(S1):48-52, 2005

Behenamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013








Behenamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Behenamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,


IJT 31(S1):77-111,2012

Behenamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Beheneth-10 1 safe in cosmetics as longas they are formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Behenoxy Dimethicone 1 IJT 22(S2):11-35,2003; Final report12/2014 available

from CIRBehenoxy PEG-10 Dimethicone* 1 Final report 12/2014

available from CIR







Behentrimonium chloride 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Behentrimonium methosulfate 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Behenyl/Isostearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating


Behenyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed

12/05Behenyl Beeswax 1 safe for use in cosmetics when


available from CIRBehenyl Behenate 1 safe for use in cosmetics when


available from CIRBehenyl Benzoate 1 not in current use* IJT 31 (S3):342-372

(2012)Behenyl Betaine 1 Up to 8.4% safe for use in cosmetics when


available from CIRBehenyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.005 to 10% IJT 33 (S2): 65-115,

2014Behenyl Erucate 1 safe for use in cosmetics when


available from CIRBehenyl Isostearate 1 not in current use* safe for use in cosmetics when


available from CIRBehenyl Olivate 1 safe for use in cosmetics when


available from CIRBentonite 1 12-80% in mud packs;

up to 8% for other usesIJT 22(S1):37-102,

2003Benzaldehyde 1 up to 0.5% IJT 25(S1):11- 27Benzalkonium Chloride 1 0.1% free active ingredient JACT 8(4):589-625,

1989 confirmed06/06

Benzalkonium Montmorillonite* 1 safe as used when formulatedto be non-irritating


Benzalkonium Sepiolite* 1 safe as used when formulatedto be non-irritating


Benzethonium Chloride 1 0.5% skin; 0.02% eye area JACT 4(5):65-106,1985 confirmed

03/04 IJT 25(S2),2006

Benzoic Acid 1 0.000002 to 5% Final amended report10/11; original IJT

20(S3):23-50, 2001Benzophenone-1 1 up to 2% JACT 2(5):35-77,

1983 confirmed09/02 IJT

24(S1):10-18, 2005







Benzophenone-11 1 up to 0.2% JACT 2(5):79-84,1983 confirmed

09/02 IJT24(S1):10-18, 2005

Benzophenone-2 1 up to 6% JACT 2(5):79-84,1983 confirmed

09/02 IJT24(S1):10-18, 2005

Benzophenone-3 1 up to 7% JACT 2(5):35-77,1983 confirmed

09/02 IJT24(S1):10-18, 2005


09/02 IJT24(S1):10-18, 2005


09/02 IJT24(S1):10-18, 2005


09/02 IJT24(S1):10-18, 2005


09/02 IJT24(S1):10-18, 2005


09/02 IJT24(S1):10-18, 2005

Benzoxiquine 1 IJT 16(S1):117-22,1997

Benzyl Alcohol (amended) 1 0.000006 to 10% amended report 10/11IJT 20(S3):23-50,

2001 (original report)Benzyl Benzoate 1 0.000005 to 4% Final report 10/11

available from CIRBenzylparaben (amended) 1 up to 0.4% if used alone;

parabens mixture up to 0.8%IJT 27(S4): 1-82,

2008 JACT 5(5):301-307, 1986

(original report)Bertholletia Excelsa Seed Oil 1 0.0003 to 0.5% Final report 03/11

available from CIRbertholletia excelsa seed oil PEG-8 esters 1 safe for use in cosmetics when


2014







Beta-glucan 1 0.000001 to 0.1% Final report 09/12available from CIR

Beta-glucan hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR

Beta-glucan palmitate 1 not in current use* Final report 09/12available from CIR

Betaine 1 0.0001 to 8.7% safe for use in cosmetics whenformulated to be non-irritating


Beta-sitosterol 1 Final report 12/2013available from CIR

Beta-sitosteryl acetate 1 Final report 12/2013available from CIR

BHA 1 up to 0.2% JACT 3(5):83-146,1984

BHT 1 up to 0.5% IJT 21(S2):19-94,2002

Biosaccharide gum-1 1 0.002 to 6% Final report 09/12available from CIR

Biosaccharide gum-2 1 1% Final report 09/12available from CIR

Biosaccharide gum-3 1 not in current use* Final report 09/12available from CIR

Biosaccharide gum-4 1 0.00001 to 5% Final report 09/12available from CIR

Biosaccharide gum-5 1 not in current use* Final report 09/12available from CIR

Biotin 1 up to 1% IJT 20(S4):1-12,2001

Bis (tripeptide-1) copper acetate 1 not in current use* Final report 06/2014available from CIR

Bisabolol 1 up to 1% IJT 18(S3):33-40,1999

Bis-cetyl/PEG-8 Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR

Bis-diglyceryl Polyacyladipate-1 1 0.2 to 10% IJT 32(S3):56-64,2013

Bis-diglyceryl Polyacyladipate-2 1 0.1 to 36% IJT 32(S3):56-64,2013

Bis-hydroxyethoxypropyl Dimethicone 1 Final report 12/2014available from CIR

Bis-isobutyl PEG/PPG-10/7/dimethicone Copolymer* 1 Final report 12/2014available from CIR

Bis-isobutyl PEG-13/dimethicone Copolymer* 1 Final report 12/2014available from CIR

Bis-isobutyl PEG-24/PPG-7/dimethicone Copolymer* 1 Final report 12/2014available from CIR







Bis-PEG/PPG-14/14 Dimethicone 1 Final report 12/2014available from CIR

Bis-PEG/PPG-15/5 Dimethicone* 1 Final report 12/2014available from CIR

Bis-PEG/PPG-16/16 PEG/PPG-16/16 Dimethicone 1 Final report 12/2014available from CIR

Bis-PEG/PPG-18/6 Dimethicone* 1 Final report 12/2014available from CIR

Bis-PEG/PPG-20/20 Dimethicone 1 Final report 12/2014available from CIR

Bis-PEG/PPG-20/5 PEG/PPG-20/5 Dimethicone* 1 Final report 12/2014available from CIR

Bis-PEG-10 Dimethicone* 1 Final report 12/2014available from CIR

Bis-PEG-12 Dimethicone 1 Final report 12/2014available from CIR

Bis-PEG-12 Dimethicone Beeswax 1 Final report 12/2014available from CIR

Bis-PEG-12 Dimethicone Candelillate 1 Final report 12/2014available from CIR

Bis-PEG-15 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR



Bis-PEG-4 Dimethicone 1 Final report 12/2014available from CIR


Bis-PEG-8 PEG-8 Dimethicone* 1 Final report 12/2014available from CIR

Bis-phenylisopropyl phenylisopropyl dimethicone/vinyldimethicone crosspolymer

1 not in current use* IJT 33 (S2): 65-115,2014

Bis-stearoxy Dimethicone* 1 Final report 12/2014available from CIR

Bis-stearoxyethyl Dimethicone* 1 Final report 12/2014available from CIR

Bis-vinyldimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Bis-vinyldimethicone/ PEG-10 dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Bis-vinyldimethicone/PPG-20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Bis-vinyldimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014







Borage Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Borago Officinalis Seed Oil 1 0.001 to 1% Final report 03/11available from CIR

Boric Acid 1 5%; but not safe for useon infant or injured skin


06/03Boron Nitride 1 Final report 06/13

available from CIRBrassica Campestris (Rapeseed) Sterols 1 Final report 12/2013

available from CIRBrassica Campestris (Rapeseeed) Oil Unsaponifiables 1 not in current use* Final report 03/11

available from CIRBrassica Campestris (Rapeseeed) Seed Oil 1 0.007 to 17% Final report 03/11

available from CIRBrassicamidopropyl dimethylamine 1 safe for use in cosmetics

when formulated to be non-irritating, which may bebased on a quantatitiverisk assessment (QRA)


Brassica Napus Seed Oil 1 not in current use* Final report 03/11available from CIR

Brassica Oleracea Acephala Seed Oil 1 not in current use* Final report 03/11available from CIR

Brassica Oleracea Italica (Broccoli) Seed Oil 1 0.001 to 3% Final report 03/11available from CIR

Brucine (denaturant) 1 IJT 27 (S1):1-43,2008

Brucine Sulfate (denaturant) 1 IJT 27 (S1):1-43,2008

Butene/propylene copolymer* 1 safe as used Final report 06/2015available from CIR

Butoxyethanol 1 up to 10% in hairand nail products

JACT 15(6):462-526,1996 confirmed

02/02 IJT24(S1):18-20, 2005

Butoxyethyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012

Butyl Acetate 1 up to 72% JACT 8(4):681-705,1989 confirmed

08/06Butyl Acrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices of

use and concentration whennot polymerized in benzene


Butyl acrylate/styrene copolymer 1 Final report 09/2014available from CIR

Butylated Hydroxyanisole (now BHA) 0 up to 0.2% JACT 3(5):83-146,1984 confirmed







09/03 IJT 25(S2),2006

Butylated Hydroxytoluene (now BHT) 0 up to 0.5% IJT 21(S2):19-94,2002

Butyl Avocadate 1 safe for use in cosmetics whenformulated to be non-irritating


Butyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)

Butyl Benzyl Phthalate 1 less than 1% JACT 11 (1):1-23,1992; IJT

30(S2):73-127, 2011Butyldimethicone methacrylate/methyl methacrylatecrosspolymer


Butylene/ethylene/propylene copolymer 1 safe as used Final report 06/2015available from CIR

Butylene/ethylene/styrene copolymer 1 Final report 09/2014available from CIR

Butylene/ethylene copolymer 1 safe as used Final report 06/2015available from CIR

Butylene Glycol 1 0.00007 to 89% JACT 4(5):223 -48,1985 confirmed

02/04 IJT 25(S2),2006

Butylene Glycol Cocoate 1 up to 2% IJT 30 (S1):5S-16S,2011

Butylene Glycol Diisononanoate 1 17% IJT 30 (S3):228-269,2011

Butyl Ester of PVM/MA Copolymer 1 up to 14% Amended FinalReport 06/09

Available from CIRJACT 12(3):243-56,

1993 (original report)Butyl Glucoside 1 safe for use in cosmetics when

formulated to be non-irritatingIJT 32 (S3): 22-48,

2013Butyl Glycolate 1 safe for use in cosmetic

products at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998







Butyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998

Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Butyl Myristate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

amended IJT 29(S3):162-86, 2010;original JACT

9(2):247-58, 1990;final report 03/2013available from CIR

Butyloctyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Benzoate 1 not in use at the time* IJT 31(S3):342-372(2012)

Butyloctyl Candelillate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Cetearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Butyloctyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,

or when increased sunsensitivity would be expected,directions for use include thedaily use of sun protection.

IJT 22(3):1-108







Butyl Oleate 1 safe for use in cosmeticswhen formulated



Butylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4): 1-82,2008 JACT


Butyl Stearate 1 up to 9% safe for use in cosmetics whenformulated to be non-irritating


06/03 IJT24(S1):21-25, 2005;final report 03/2013available from CIR

Butyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes



IJT 28(S3):68-133,2009

Butyrospermum Parkii (Shea) Butter 1 0.0005 to 60% Final report 03/11available from CIR

Butyrospermum Parkii (Shea) Butter Unsaponifiables 1 0.06 to 3% Final report 03/11available from CIR

Butyrospermum Parkii (Shea) Oil 1 0.01 to 15% Final report 03/11available from CIR

C10-11 isoparaffin 1 safe when formulatedto be non- irritating

IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)

C10-16 Alkyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

C10-16 Pareth-1 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C10-40 Isoalkyl acid Octododecanol Esters 1 not in current use* safe as used in cosmeticswhen formulated



C10-40 Isoalkyl acid phytosterol esters 1 Final report 12/2013available from CIR


IJT 31(S3): 269-295(2012)








IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C11-15 Sec-Pareth-12 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244,2012


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C12-13 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating



IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)








IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012


IJT 31(S2):169-244,2012







C12-15 Alkyl Benzoate 1 0.0008 to 59% IJT 31 (3):342-372(2012)

C12-15 alkyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating


C12-15 Alkyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 32 (S3): 22-48,2013


IJT 32 (S3): 22-48,2013


IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)








IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C14-18 alkyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


C14-18 glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

C14-30 Alkyl Beeswax 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


C15-18 glycol 1 concentration not reported* IJT 31 (S2): 147-168,2013

C15-35 isoparaffin/isoalkylcycloalkanes 1 safe when formulatedto be non-irritating

IJT 31(S3): 269-295(2012)

C16-17 Alkyl Benzoate 1 not in current use * IJT 31(3):342-372(2012)

C16-22 Acid Amide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

C16-36 alkyl stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


C18-22 hydroxyalkyl hydroxypropyl guar 1 not in current use* IJT 34(S1): 35-65,2015


C18-38 Alkyl Beeswax 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


C18-38 Alkyl C24-54 Acid Ester 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating



IJT 31(S3): 269-295(2012)


IJT 32 (S3): 22-48,2013

C20-22 Alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating









C20-40 Alkyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


C20-40 Alkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating



IJT 31(S3): 269-295(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C24-28 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003

C30-45 alkyl cetearyl dimethicone crosspolymer 1 0.2 to 4% IJT 33 (S2): 65-115,2014

C30-45 Alkyl Dimethicone 1 2% IJT 22(S2):11-35,2003

C30-45 alkyl dimethicone/ polycyclohexene oxidecrosspolymer

1 concentration not reported * IJT 33 (S2): 65-115,2014

C30-45 Alkyl Methicone 1 not in current use * IJT 22(S2):11-35,2003

C30-50 Alkyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating





IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

C32-36 Isoalkyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating





IJT 31(S2):169-244(2012)

C40-60 Pareth-3 and -10 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)

C4-24 alkyl dimethicone/ divinyldimethicone crosspolymer 1 2% IJT 33 (S2): 65-115,2014

C4-5 Isoalkyl Cocoate 1 safe for use in cosmetics whenformulated to be non-irritating


C4-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR







C5-6 Olefin/styrene copolymer 1 not in current use* Final report 09/2014available from CIR


IJT 31(S3): 269-295(2012)

C8-10 alkyl ethyl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


C8-22 Alkyl Acrylates/Methacrylic Acid Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene



IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)

C9-11 Pareth-3 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)


IJT 31(S3): 269-295(2012)

C9-15 alkyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating




IJT 31(S2):169-244(2012)


IJT 31(S3): 269-295(2012)

Caesalpinia spinosa gum 1 0.002 to 0.5% IJT 34(S1): 35-65,2015

Caesalpinia spinosa hydroxypropyltrimonium chloride 1 not in current use * IJT 34(S1): 35-65,2015

Calcium/Sodium PVM/MA Copolymer (amended) 1 concentration not reported * Amended FinalReport 06/09


1993 (original report)







Calcium Acetate 1 concentration not reported * IJT 31(S1):112-136,2012

Calcium Alginate 1 Final report 09/2015available from CIR

Calcium Aluminum Borosilicate 1 0.001 to 33% IJT 32(S3): 65-72,2013

Calcium Ascorbate 1 not in current use * IJT 24(2):51-111,2005

Calcium Aspartate 1 not in current use * IJT 32(S4):41-64,2013

Calcium Benzoate 1 0.002 to 0.004% Amended final report09/11 available from

CIRCalcium Carboxymethyl Cellulose 1 not in use at the time* IJT 5 (3): 1-59, 1986

(original report);Amended safety

assessment 03/09 -Available from CIR

Calcium Carrageenan 1 Final report 09/2015available from CIR

Calcium citrate 1 not in use at the time* IJT 33 (S2): 16-46,2014

Calcium Disodium EDTA 1 not in current use * IJT 21(S2):95-142,2002

Calcium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Calcium Gluconate 1 Final report 03/2014available from CIR

Calcium Glycinate 1 3% IJT 32(S4):41-64,2013

Calcium Glycolate 1 Glycolic and Lactic Acid,their common salts and their



than or equal to 3.5, whenformulated to avoid increasing


IJT 17(S1):1-242,1998

Calcium Hydroxide 1 safe in hair straighteners anddepilatories under conditionsof recommended use: users

should minimize skin contact;all other uses safe when









Calcium Lactate 1 Glycolic and Lactic Acid,their common salts and their





IJT 17(S1):1-242,1998

Calcium Lauroyl Taurate 1 when formulatedto be non-irritating

Final Report 12/2015available from CIR

Calcium Myristate 1 not in use at the time* IJT29(S3) :162-186,2010

Calcium PCA 1 safe as used; shouldnot be used in cosmetic

products in which N-nitrosocompounds can be formed


Calcium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Calcium Silicate 1 up to 10% IJT 22(S1):37-102,2003

Calcium sodium borosilicate 1 0.0001 to 97% IJT 32(S3): 65-72,2013

Calcium Starch Isododecenylsuccinate 1 Final report 09/2015available from CIR

Calcium Starch Octenylsuccinate 1 Final report 09/2015available from CIR

Calcium Stearate 1 up to 23% JACT 1(2):143-77,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Calcium Thioglycolate 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair

products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressersshould avoid skin contact

and minimize consumer skin

IJT 28(S3):68-133,2009







Calcium titanium borosilicate 1 6% IJT 32(S3): 65-72,2013

Calcium Xylenesulfonate 1 not in current use * IJT 30(S3):270-283,2011

Calendula Officinalis Extract (amended) 1 concentration not reported * IJT 20(S2):13-20,2001 (original

report); IJT 29 (S4):221-243, 2010

Calendula Officinalis Flower 1 concentration not reported * IJT 20(S2):13-20,2001 (original

report); IJT 29 (S4):221-243, 2010

Calendula Officinalis Flower Extract (amended) 1 up to 6% IJT 29 (S4): 221-243,2010

Calendula Officinalis Flower Oil (amended) 1 up to 0.1% IJT 29 (S4): 221-243,2010

Calendula Officinalis Seed Oil 1 concentration not reported * IJT 20(S2):13-20,2001 (original

report); IJT 29 (S4):221-243, 2010

Camellia Japonica Seed Oil 1 0.01 to 0.2% Final report 03/11available from CIR

Camellia Kissi Seed Oil 1 0.1 - 10% Final report 03/11available from CIR

Camellia Oleifera Seed Oil 1 0.003 to 3% Final report 03/11available from CIR

Camellia Sinensis Catechins 1 not in current use * safe for use in cosmeticswhen formulated tobe non-sensitizing


Camellia Sinensis Flower/Leaf/Stem Juice 1 Final report 09/2014available from CIR

Camellia Sinensis Flower Extract 1 Final report 09/2014available from CIR

Camellia Sinensis Leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Camellia Sinensis Leaf Extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Camellia Sinensis Leaf Oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Camellia Sinensis Leaf Powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Camellia Sinensis Leaf Water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing








Camellia Sinensis Root Extract 1 Final report 09/2014available from CIR

Camellia Sinensis Seedcoat powder 1 Final report 09/2014available from CIR

Camellia Sinensis Seed extract 1 Final report 09/2014available from CIR

Camellia Sinensis Seed Oil 1 0.10% Final report 03/11available from CIR

Camellia Sinensis Seed Powder 1 Final report 09/2014available from CIR

Camellina Sativa Seed Oil 1 0.002 to 1% Final report 03/11available from CIR

Canarium Indicum Seed Oil 1 not in current use * Final report 03/11available from CIR

Candelilla Wax; now Euphorbia Cerifera (Candelilla) Wax 1 up to 27% JACT 3(3):1-41,1984 confirmed

06/03; IJT24(S1):1-102, 2005

Canolamidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,


IJT 31(S1):77-111,2012

Canola Oil 1 0.0002 to 73% Final report 03/11available from CIR

Canola Oil Unsaponifiables 1 0.00% Final report 03/11available from CIR

Canola Sterols 1 Final report 12/2013available from CIR

Capramide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Caprooyl phytosphingosine 1 safe as used Final report 03/2015available from CIR

Caprooyl sphingosine 1 safe as used Final report 03/2015available from CIR

Caproyl sphingosine* 1 safe as used Final report 03/2015available from CIR

Capryl/capramidopropyl betaine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,

IJT 31(S1):77-111,2012








Capryleth-4 1 safe in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Capryleth-5 1 safe in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Caprylic/Capric/Coco Glycerides (amended) 1 up to 4% IJT 30(S1):5S-16SCaprylic/Capric Triglyceride 1 up to 84% JEPT 4(4):105-20,


22(S1):1-35, 2003Capryloyl Collagen Amino Acids 1 not in current use * safe for use in cosmetics when


available from CIRCapryloyl Glycine 1 safe for use in cosmetics when


available from CIRCapryloyl Gold of Pleasure Amino Acids 1 not in current use * safe for use in cosmetics when


available from CIRCapryloyl Keratin Amino Acids 1 not in current use * safe for use in cosmetics when


available from CIRCapryloyl Pea Amino Acids 1 not in current use * safe for use in cosmetics when


available from CIRCapryloyl Quinoa Amino Acids 1 not in current use * safe for use in cosmetics when


available from CIRCapryloyl Salicylic Acid 1 safe when formulated to

avoid irritation and to avoidincreasing sun sensitivity,


IJT 22(S3):1-108,2003

Capryloyl Silk Amino Acids 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Caprylyl/capryl glucoside 1 safe in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Caprylyl Butyrate 1 not in current use * safe in cosmetics whenformulated to be non-irritating


Caprylyl Caprylate 1 safe in cosmeticswhen formulated



Caprylyl Eicosenoate 1 safe in cosmeticswhen formulated



Caprylyl Glucoside 1 safe in cosmeticswhen formulated


IJT 32 (S3): 22-48,2013







Caprylyl Glyceryl Ether 1 not in current use * IJT 32 (S3): 5-21,2013

Caprylyl Glycol 1 0.00003 to 5% IJT 31 (S2): 147-168,2012

Capsaicin 1 safe in the practices of useand concentration described in

the safety assessment, whenformulated not to be irritating

IJT 26(S1):3-106,2007

Capsicum Annuum Extract 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Annuum Fruit Extract 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Annuum Fruit Powder 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Annuum Resin 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Frutescens Fruit 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Frutescens Fruit Extract 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Capsicum Frutescens Resin 1 safe in the practices of useand concentration described in


IJT 26(S1):3-106,2007

Captan 1 JACT 8(4):643-80,1989

Carbomer-910 1 not in current use * JACT 1(2)109-41, 1982

confirmed 11/02 IJT22(S1):1-35, 2003

Carbomer-934, -934P, -940, -941 1 up to 2% JACT 1(2)109-41,1982 confirmed

11/02 IJT22(S1):1-35, 2003

Carbomer-934P 1 up to 2% JACT 1(2)109-41,1982 confirmed







11/02 IJT22(S1):1-35, 2003

Carbomer-940 1 up to 2% JACT 1(2)109-41,1982 confirmed

11/02 IJT22(S1):1-35, 2003

Carbomer-941 1 up to 2% JACT 1(2)109-41,1982 confirmed

11/02 IJT22(S1):1-35, 2003

Carbomer-962 1 not in current use * JACT 1(2)109-41, 1982

confirmed 11/02 IJT22(S1):1-35, 2003

Carboxymethyl Dextran 1 not in current use * Tentative report06/12 available from

CIRCarboxymethyl Hydroxyethylcellulose 1 up to 3% Amended safety


Carboxymethyl hydroxypropyl guar 1 not in current use * IJT 34(S1): 35-65,2015

Carica Papaya Seed Oil 1 0.10% Final report 03/11available from CIR

Carnauba (Copernicia Cerifera) Wax 0 up to 20% JACT 3(3):1-41,1984 confirmed

06/03; IJT24(S1):1-102, 2005

Carnitine 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Carnitine HCl 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Carnitine hydroxycitrate 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Carnitine PCA 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Carrageenan 1 Final report 09/2015available from CIR

Carthamus Tinctorius (Safflower) Seed Oil 1 up to 84% in 2004 JACT 4(5):171-97,1985 confirmed

02/04; IJT25(S2) :1-89,2006;Final report 03/11

available from CIRCarvacrol 1 up to 0.5% IJT 25(S1):29-127,

2006Carya Illinoensis (Pecan) Seed Oil 1 not in current use * Final report 03/11

available from CIR







Caryocar Brasiliense Fruit Oil 1 0.0005 to 0.2% Final report 03/11available from CIR

Cassia Angustifolia Seed Polysaccharide 1 Final report 09/2015available from CIR

Cassia Gum 1 not in current use * IJT 34 (S1): 35-65,2015

Cassia hydroxypropyltrimonium chloride 1 0.06 to 0.4% in rinse-off IJT 34 (S1): 35-65,2015

Castor oil phosphate 1 safe for use in cosmetics whenformulated to be non-irritating


Cellobiose octanonanoate 1 not in current use * IJT 30(S3):228-269,2011

Cellulose (amended) 1 up to 88% Amended safetyassessment 03/09 -

Available from CIRCellulose Acetate (amended) 1 up to 2% Amended safety


Cellulose Acetate Butyrate (amended) 1 up to 17% Amended safetyassessment 03/09 -

Available from CIRCellulose Acetate Propionate 1 not in use at the time* Amended safety


Cellulose Gum (amended) 1 up to 20% Amended safetyassessment 03/09 -


1986 (original report)Cellulose Succinate 1 not in use at the time* Amended safety


Centella asiatica callus culture 1 safe as used when formulatedto be non-sensitizing


Centella asiatica extract 1 safe as used when formulatedto be non-sensitizing


Centella asiatica flower/leaf/stem extract 1 safe as used when formulatedto be non-sensitizing


Centella asiatica leaf cell culture extract 1 safe as used when formulatedto be non-sensitizing


Centella asiatica leaf extract 1 safe as used when formulatedto be non-sensitizing


Centella asiatica leaf water 1 safe as used when formulatedto be non-sensitizing


Centella asiatica meristem cell culture 1 safe as used when formulatedto be non-sensitizing


Centella asiatica meristem cell culture extract 1 safe as used when formulatedto be non-sensitizing








Centella asiatica root extract 1 safe as used when formulatedto be non-sensitizing


Ceramide 1 [retired] 1 safe as used Final report 03/2015available from CIR

Ceramide 1A [retired] 1 safe as used Final report 03/2015available from CIR



Ceramide 4* [retired] 1 safe as used Final report 03/2015available from CIR


Ceramide 6 II [retired] 1 safe as used Final report 03/2015available from CIR

Ceramide AP 1 safe as used Final report 03/2015available from CIR

Ceramide AS 1 safe as used Final report 03/2015available from CIR

Ceramide EOP 1 safe as used Final report 03/2015available from CIR

Ceramide EOS 1 safe as used Final report 03/2015available from CIR

Ceramide NG* 1 safe as used Final report 03/2015available from CIR

Ceramide NP 1 safe as used Final report 03/2015available from CIR

Ceramide NS 1 safe as used Final report 03/2015available from CIR

Ceramide NS dilaurate* 1 safe as used Final report 03/2015available from CIR

Ceratonia siliqua gum 1 0.0003 to 0.07% IJT 34(S1): 35-65,2015

Ceresin 1 up to 20% JACT 3(3):43-99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Ceteareth-10 1 Safe as used in cosmeticswhen formulated


IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)









IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)









IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)









IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)



IJT 18(S3):41-49,1999; IJT

31(S2):169-244(2012)

Ceteartrimonium chloride 1 safe in the present practices ofuse and concentration, when


IJT 31(S3): 296-341(2012)

Cetearyl Alcohol 1 up to 25% JACT 7(3):359-413,1988 confirmed

12/05Cetearyl Behenate 1 not in current use * safe for use in cosmetics when


available from CIRCetearyl Candelillate Final report 03/2013

available from CIRCetearyl dimethicone/vinyl dimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,

2014Cetearyl dimethicone crosspolymer 1 00.002 to 23% IJT 33 (S2): 65-115,

2014Cetearyl ethylhexanoate 1 safe for use in cosmetics when


available from CIRCetearyl glucoside 1 safe for use in cosmetics when


2013Cetearyl Isononanoate 1 up to 50% safe for use in cosmetics when


2011; Final Report







03/2013 availablefrom CIR

Cetearyl Methicone 1 up to 1% IJT 22(S2):11-35,2003

Cetearyl Nonanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

IJT 30(S3):228-269,2011; Final Report03/2013 available

from CIRCetearyl Octanoate (aka Cetearyl Ethylhexanoate) 1 up to 25% JACT 1(4):81-92,

1982 confirmed06/03 IJT 25(S2),

2006Cetearyl Olivate 1 safe for use in cosmetics when

formulated to be non-irritatingFinal Report 03/2013

available from CIRCetearyl Palmate 1 not in current use* safe for use in cosmetics when


available from CIRCetearyl Palmitate 1 not in current use* safe for use in cosmetics when


available from CIRCetearyl Phosphate 1 not in current use* safe for use in cosmetics when


available from CIRCetearyl Rice Branate 1 not in current use* safe for use in cosmetics when


available from CIRCetearyl Stearate 1 safe for use in cosmetics when


available from CIRCeteth-1 1 safe for use in cosmetics

when formulatedto be non- irritating

IJT 31(Suppl.2):169-244, 2012;

IJT 18(2):1-8, 1999(original report)

Ceteth-10 1 safe for use in cosmeticswhen formulated


IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;










IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;










IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;




IJT 31(Suppl.2):169-244, 2012;


Cetethyl Morpholinium Ethosulfate 1 IJT 20(S3):99 -102,2001

Cetoleth-10 1 safe as used when formulatedto be non- irritating

IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012


IJT 31(Suppl.2):169-244, 2012







Cetrimonium Bromide 1 safe as used when formulatedto be non- irritating

IJT16(S3):195-220,1997

(original report);IJT 31(S3): 296-341

(2012)Cetrimonium Chloride 1 safe as used when formulated

to be non- irritatingIJT

16(S3):195-220,1997(original report);

IJT 31(S3): 296-341(2012)

Cetrimonium methosulfate 1 safe as used when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Cetyl Acetate 1 0.01 to 17% IJT 31(S1):112-136,2012

Cetyl Alcohol 1 up to 50% JACT 7(3):359-413,1988 confirmed

12/05Cetyl Babassuate 1 Safe as used in cosmetics

when formulatedto be non-irritating


Cetyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated



Cetyl Betaine 1 0.36 to 7.4% Safe as used in cosmeticswhen formulated



Cetyl Caprate 1 Safe as used in cosmeticswhen formulated



Cetyl Caprylate 1 Safe as used in cosmeticswhen formulated


Safe as used incosmetics when


Cetyl Dimethicone 1 up to 10% IJT 22(S2):11-35,2003

Cetyl dimethicone/bis-vinyldimethicone crosspolymer 1 0.001 to 0.005% IJT 33 (S2): 65-115,2014

Cetyl Dimethyloctanoate 1 not in current use* Safe as used in cosmeticswhen formulated


Safe as used incosmetics when


Cetyl Esters 1 up to 7% Safe as used in cosmeticswhen formulated


IJT16(S1):123-30,1997;final report 03/2013available from CIR

Cetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating








Cetyl Glyceryl Ether/ Chimyl Alcohol 1 IJT 32 (S3): 5-21,2013

Cetyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Cetyl hexacosyl dimethicone/bis-vinyldimethiconecrosspolymer


Cetyl Hydroxyethylcellulose (amended) 1 up to 2% Amended safetyassessment 03/09 -

Available from CIRCetyl isononanoate 1 not in current use* safe for use in cosmetics when


2011; Final Report03/2013 available

from CIRCetyl Lactate (Amended) 1 safe for use in cosmetic

products at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998 JACT

1(2):97-107, 1982(Original Report)

Cetyl Laurate 1 safe for use in cosmeticswhen formulated



Cetyl Myristate 1 up to 6% safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Cetyl Myristoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Cetyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Cetyl Palmitate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating



Cetyl PEG/PPG-10/1 Dimethicone 1 Final report 12/2014available from CIR

Cetyl PEG/PPG-15/15 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR

Cetyl PEG/PPG-7/3 Dimethicone* 1 Final report 12/2014available from CIR







Cetyl PEG-8 Dimethicone* 1 Final report 12/2014available from CIR

Cetyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating


Cetyl Ricinoleate 1 up to 10% safe for use in cosmetics whenformulated to be non-irritating

IJT 26(S3): 31-77,2007; final report03/2013 available

from CIRCetyl Stearate 1 up to 15% safe for use in cosmetics when

formulated to be non-irritatingJACT 4(5):107-46,


24(S1):21-25, 2005;final report 03/2013available from CIR

Cetyl Tallowate 1 safe for use in cosmetics whenformulated to be non-irritating


Chamomilla recutita (matricaria) extract 1 Final report 12/2013available from CIR

Chamomilla recutita (matricaria) flower 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Chamomilla recutita (matricaria) flower/leaf/stem extract 1 Final report 12/2013available from CIR

Chamomilla recutita (matricaria) flower/leaf/stem water 1 Final report 12/2013available from CIR

Chamomilla recutita (matricaria) flower/leaf extract 1 Final report 12/2013available from CIR

Chamomilla recutita (matricaria) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Chamomilla recutita (matricaria) flower oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Chamomilla recutita (matricaria) flower powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Chamomilla recutita (matricaria) flower water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing


Chamomilla recutita (matricaria) leaf extract 1 Final report 12/2013available from CIR

Chamomilla recutita (matricaria) oil 1 Final report 12/2013available from CIR

Chenopodium Quinoa Seed Oil 1 0.30% Final report 03/11available from CIR

Chimyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating








Chimyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Chlorhexidine 1 up to .14% JACT 12(3):201-23,1993 IJT 18(2):69,

1999 (Note)Chlorhexidine Diacetate 1 up to .19% JACT 12 (3):201-23,

1993 IJT 18(2):69,1999 (Note)

Chlorhexidine Digluconate 1 up to .20% JACT 12 (3):201-23,1993 IJT 18(2):69,

1999 (Note)Chlorhexidine Dihydrochloride 1 up to .16% JACT 12(3):201-23,

1993 IJT 18(2):69,1999 (Note)

Chloroacetamide 1 sensitization JACT 10(1):21- 32,1991

Chlorophene 1 IJT 23(S1):1-27 2004Chlorothymol (amended) 1 up to 0.5% IJT 25 (S1):29-127,

2006Chloroxylenol 1 up to 0.5% JACT 4(5):147-69,


2006Chlorphenesin 1 0.000008 to 0.32% IJT 33 (2): 5-15,

2014Cholesterol 1 up to 3% JACT 5(5):491-516,

1986 confirmed12/04IJT 25(S2), 2006

Cholesteryl Nonanoate 1 up to 30% IJT 30 (S3):228-269,2011

Choleth-24 1 up to 1.3% JACT 1(4):119-26,1982 confirmed

06/02 IJT24(S1):32-34, 2005

Choline chloride 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Cichorium Intybus (Chicory) Root Oligosaccharides 1 Final report 09/2015available from CIR

Citric acid 1 0.0000005 to 39% IJT 33 (S2): 16 -46,2014

Citrullus Lanatus (Watermelon) Seed Oil 1 2% Final report 03/11available from CIR

Citrus Aurantifolia (Lime)/Citrus Limon (Lemon) FruitWater

1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,

provided that leave-onproducts do not contain more








than 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).

Citrus Aurantifolia (lime) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,

provided that leave-onproducts do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).


Citrus Aurantifolia (lime) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantifolia (lime) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantifolia (lime) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantifolia (Lime) Seed Oil 1 not in current use* safe for use in cosmeticproducts when finished

products, excluding rinse-off products, do not contain

more than 0.0015% (15ppm) 5-methyoxypsoralen

(5-MOP), and whenformulated to be non-

sensitizing and non-irritating.

Final report 03/11available from CIR;Final report 09/2014

available from CIR

Citrus Aurantifolia (Lime) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR

Citrus Aurantium Amara (Bitter Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,









Citrus Aurantium Amara (Bitter Orange) Fruit Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Amara (Bitter orange) Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Aurantium Bergamia (Bergamot) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Bergamia (Bergamot) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Currassuviensis Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished






Citrus Aurantium Dulcis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-








sensitizing and non-irritating,provided that leave-on

products do not contain morethan 0.0015% (15 ppm) 5-methoxypsoralen (5-MOP).

Citrus Aurantium Dulcis (orange) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Dulcis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Dulcis (orange) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Aurantium Dulcis (Orange) Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Aurantium Dulcis (Orange) Seed Oil 1 not in current use* Final report 03/11available from CIR

Citrus Aurantium Dulcis (Orange) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR

Citrus Aurantium Sinensis (orange) Fiber 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Clementina Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Clementina Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Clementina peel oil 1 not in current use* safe for use in cosmeticproducts when finished






Citrus Depressa Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Depressa Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Glauca Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Grandis/Paradisi Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Grandis (grapefruit) Fruit/peel Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Grandis (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Grandis (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Grandis (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Grandis (Grapefruit) Peel Oil 1 safe for use in cosmeticproducts when finished



(5-MOP), and when








formulated to be non-sensitizing and non-irritating.

Citrus Grandis (Grapefruit) Seed Oil 1 not in current use* Final report 03/11available from CIR

Citrus Grandis (Grapefruit) Seed Oil Unsaponifiables 1 not in current use* Final report 03/11available from CIR

Citrus Hassaku/natsudaidai Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Hassaku/natsudaidai Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Hassaku Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Iyo Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Iyo Peel Oil 1 not in current use* safe for use in cosmeticproducts when finished

products, excluding rinse-








off products, do not containmore than 0.0015% (15

ppm) 5-methyoxypsoralen(5-MOP), and when


Citrus Jabara Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Japonica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Junos Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Junos Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Junos Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Junos Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-










Citrus Junos Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Junos Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Limon (lemon) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (lemon) Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (lemon) Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (lemon) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-










Citrus Limon (lemon) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (lemon) Juice Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (lemon) Juice Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Limon (Lemon) Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Limon (Lemon) Seed Oil 1 6% Final report 03/11available from CIR

Citrus Madurensis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,









Citrus Madurensis Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Medica Vulgaris Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Medica Vulgaris Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Nobilis (mandarin Orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Nobilis (mandarin Orange) Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Nobilis (Mandarin Orange) Peel Oil 1 safe for use in cosmeticproducts when finished



(5-MOP), and when









Citrus Paradisi (grapefruit) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Paradisi (grapefruit) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Paradisi (grapefruit) Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Paradisi (Grapefruit) Seed Oil 1 0.01 to 20% Final report 03/11available from CIR

Citrus Reticulata (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Reticulata (tangerine) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Reticulata (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,

provided that leave-on









Citrus Reticulata (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Shunkokan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Sinensis (orange) Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Sinensis (orange) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Sphaerocarpa Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Sudachi Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Sudachi Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tachibana/reticulata Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tachibana/Reticulata Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Tamurana Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tangelo Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tangelo Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Tangerina (tangerine) Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tangerina (tangerine) Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tangerina (Tangerine) Peel Oil 1 safe for use in cosmeticproducts when finished






Citrus Tankan Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Tankan Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu/citrus Reticulata/citrus Iyo Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Unshiu/sinensis/reticulata Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu Fruit Juice 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu Fruit Juice Ferment Extract Filtrate 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu Fruit Oil 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Citrus Unshiu Fruit Powder 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Citrus Unshiu Fruit Water 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Coal Tar 1 IJT 27(S2):1-24,2008

Cocamide DEA (Amended) 1 safe in the present practices ofuse and concentration when


considered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic product

IJT 32(S1):36-58,2013

Cocamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015; IJT 18(2):9-16,1999 (original report)

Cocamide methyl MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015; IJT 18(2):9-16,1999 (original report)

Cocamidopropylamine Oxide 1 safe for use in rinse-offs(up to 4%); insufficient

data for leave-ons

IJT 27(S1): 55-62,2008 IJT 19(2):1-5,

2000 (original report)Cocamidopropyl betainamide MEA chloride 1 safe in the present practices

of use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015







Cocamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which

may be based on aquantitative risk assessment

JACT 10(1):33-52,1991; IJT

31(S1):77-111, 2012

Cocamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Coceth-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Coco/oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


JACT 10(1):33-52,1991; IJT

31(S1):77-111, 2012

Coco/sunfloweramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


JACT 10(1):33-52,1991; IJT

31(S1):77-111, 2012

Cocoamphoacetate 1 up to 6% JACT 9(2):121-42,1990 confirmed

04/06







Cocoamphodiacetate 1 up to 12% JACT 9(2):121-42, 1990 confirmed

04/06Cocoamphodipropionate 1 up to 15% JACT 9 (2):121-42,

1990 confirmed04/06

Cocoamphopropionate 1 up to 10% JACT 9(2):121-42, 1990 confirmed

04/06Coco-betaine 1 0.53 to 9.8% safe for use in cosmetics when


available from CIRCoco-Caprylate 1 safe for use in cosmetics



Coco-Caprylate/Caprate 1 safe for use in cosmetics whenformulated to be non-irritating


Coco-glucoside 1 safe for use in cosmeticswhen formulated


IJT 32 (S3): 22-48,2013

Cocoglycerides (amended) 1 up to 14% IJT 30 (S1):5S-16SCoconut Acid (amended) 1 up to 14% in 2011 JACT 5(3):103-21,

1986 (originalreport); IJT 30 (s1):

5s-16s, 2011; alsoincluded in the Plant

Derived Fatty AcidOils report 03/11

Coconut Alcohol (amended) 1 up to 0.9% IJT 30 (S1):5S-16S,2011

Coconut Oil Decyl Esters (amended) 1 not in current use1 IJT 30(S1):5S-16S,2011

Coconut Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Coco-Rapeseedate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Cocos Nucifera (Coconut) Oil (amended) 1 up to 80% in 2011 JACT 5(3):103-21,1986 (original

report); IJT 30 (s1):5s-16s, 2011; also

included in the PlantDerived Fatty Acid

Oils report 03/11Cocos Nucifera (Coconut) Seed Butter 1 not in current use* Final report 03/11

available from CIRCocotrimonium chloride 1 safe when formulated

to be non- irritatingIJT 31(S3): 296-341

(2012)Cocotrimonium methosulfate 1 safe when formulated


(2012)







Cocoylcholine methosulfate 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Cocoyl glutamic acid 1 safe for use in cosmetics whenformulated to be non-irritating


Cocoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Coix Lacryma-Jobi (Job's Tears) Seed Oil 1 not in current use* Final report 03/11available from CIR

Collagen Amino Acids 1 IJT 33(S4):5-12,2014

Collodion 1 Final report 06/13available from CIR

Copernicia Cerifera (Carnauba) Wax 1 up to 20% JACT 3(3):1-41,1984 confirmed

06/03 IJT24(S1):48-52, 2005

Copper citrate 1 not in current use* IJT 33 (S2): 16-46,2014

Copper tripeptide-1 1 Final report 06/2014available from CIR

Corn Acid 1 not in current use* IJT 30(S1):17- 39,2011; final report

03/11 available fromCIR

Cornamide/cocamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Cornamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013








Corn Gluten Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Corn Glycerides 1 not in current use* Final Report 09/08available from CIR

Corn Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Corn Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Corn Starch Modified 1 Final report 09/2015available from CIR

Corylus Americana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001

Corylus Americana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001

Corylus Americana (Hazelnut) Seed Oil 1 IJT 20(S1):15-20,2001; Final report


Corylus Avellana (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001

Corylus Avellana (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001

Corylus Avellana (Hazelnut) Seed Oil 1 0.005 to 98% IJT 20(S1):15-20,2001; Final report


Corylus Rostrata (Hazelnut) Leaf Extract 1 IJT 20(S1):15-20,2001

Corylus Rostrata (Hazelnut) Seed Extract 1 IJT 20(S1):15-20,2001

Cottonseed Acid 1 not in current use* IJT 20 (S2):21-29,2001; Final amended

report 03/11 availablefrom CIR

Cottonseed Glyceride 1 safe as used in cosmeticproducts, provided that

established and imposed limitson gossypol, heavy metals,

and pesticide concentrationsare not exceeded

IJT 20(S2):21-29,2001

Crambe Abyssinica Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Crotonic acid/vinyl C8-12 isoalkyl esters/VA/bis-vinyldimethicone crosspolymer


Cucumis Sativus (Cucumber) Extract 1 0.0002 to 0.003% IJT 33 (2): 47-64,2014







Cucumis Sativus (Cucumber) Fruit 1 concentration not reported* IJT 33 (2): 47-64,2014

Cucumis Sativus (Cucumber) Fruit Extract 1 0.0000001 to 1% IJT 33 (2): 47-64,2014

Cucumis Sativus (Cucumber) Fruit Water 1 0.05 to 3% IJT 33 (2): 47-64,2014

Cucumis Sativus (Cucumber) Juice 1 concentration not reported* IJT 33 (2): 47-64,2014

Cucumis Sativus (Cucumber) Seed Extract 1 0.01 to 0.08% IJT 33 (2): 47-64,2014

Cucumis Sativus (Cucumber) Seed Oil 1 concentration not reported* Final report 03/2011available from CIR

Cucurbita Pepo (Pumpkin) Seed Oil 1 0.003 to 0.1% Final report 03/2011available from CIR

Cupuassauamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Cyamopsis tetragonoloba (guar) gum 1 0.02 to 1% in leave-on;0.09 to 5% in rinse-off

IJT 34 (S1): 35-65,2015

Cyclodextrin 1 Final report 09/2015available from CIR

Cyclodextrin Hydroxypropyltrimonium Chloride 1 Final report 09/2015available from CIR

Cyclodextrin Laurate 1 Final report 09/2015available from CIR

Cycloheptasiloxane (amended) 1 not reported * IJT 30(S3):149-227,2011

Cyclohexasiloxane(amended) 1 up to 48% IJT 30 (S3):149-227,2011

Cyclohexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Cyclomethicone (amended) 1 up to 89% JACT 10 (1):9-19,1991 (original

report); IJT30(S3):149-227, 2011

Cyclopentasiloxane (amended) 1 up to 93% IJT 30(S3):149-227,2011

Cyclotetraglucose 1 Final report 09/2015available from CIR







Cyclotetrasiloxane (amended) 1 up to 28% IJT 30(S3):149-227,2011

Cynara Cardunculus Seed Oil 1 not in current use* Final report 03/11available from CIR

Cysteine 1 0.0001 to 5% IJT 32(S4):41-64,2013

Cysteine HCl 1 0.0001 to 6% IJT 32(S4):41-64,2013

Cystine 1 0.001 to 3% IJT 32(S4):41-64,2013

DEA-C12-13 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except

do not use in cosmeticproducts in which N-nitrosocompounds can be formed


DEA-C12-13 Pareth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-C12-15 Alkyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Cetyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Cocamphodipropionate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Dodecylbenzenesulfonate (amended) 1 safe in the present practicesof use and concentrationwhen formulated to be

IJT 29 (S4): 288-305,2010 - Final amended







non-irritating, exceptdo not use in cosmetic



DEA-Isostearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Laureth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Lauryl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA- Linoleate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Methyl Myristate Sulfonate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Myreth Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Myristate 1 safe in the present practicesof use and concentrationwhen formulated to be








non-irritating, exceptdo not use in cosmetic


DEA-Myristyl Sulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



DEA-Stearate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except



Decene/butene copolymer 1 safe as used Final report 06/2015available from CIR

Deceth-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Decyl betaine 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyl Castorate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyl Cocoate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 30(S1):5S-16S;final report 03/2013available from CIR







Decylene Glycol 1 concentration not reported* IJT 31 (S2): 147-168,2012

Decyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Decyl Isostearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyl Jojobate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyl Laurate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyl Myristate 1 not in use at the time* safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Decyl Oleate 1 up to 88% safe for use in cosmetics whenformulated to be non-irritating


11/01 IJT22(S1):1-35, 2003;


Decyl Olivate 1 safe for use in cosmeticswhen formulated



Decyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating


Decyl succinate 1 not in use at the time* IJT 31 (S1):5-76,2012

Decyltetradeceth-10 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

Decyltetradecyl Cetearate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Decyltetradecyl ethylhexanoate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Defatted Citrus Unshiu Fruit 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,










Dehydroacetic Acid 1 up to 0.7% JACT 4(3):123-59, 1985 confirmed

11/03 IJT 25(S2),2006

Dehydroxanthan gum 1 0.1 to 1% Final report 09/12available from CIR

Denatonium Benzoate 1 1/16 avoidupois ounceper 100 gal alcohol

IJT 27 (S1):1-43,2008

Dextran 1 0.000005 to 0.2% Final report 09/12available from CIR

Dextran hydroxypropyltrimonium chloride 1 not in current use * Final report 09/12available from CIR

Dextran sulfate 1 0.01 to 0.1% Final report 09/12available from CIR

Dextrin 1 Final report 09/2015available from CIR

Dextrin Behenate 1 Final report 09/2015available from CIR

Dextrin Isostearate 1 Final report 09/2015available from CIR

Dextrin Laurate 1 Final report 09/2015available from CIR

Dextrin Myristate 1 Final report 09/2015available from CIR

Dextrin Palmitate 1 Final report 09/2015available from CIR

Dextrin Palmitate/Ethylhexanoate 1 Final report 09/2015available from CIR

Dextrin Stearate 1 Final report 09/2015available from CIR

Diammonium citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014

Diammonium EDTA 1 not in current use * IJT 21 (S2):95-142,2002

Diamyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Diazolidinyl Urea 1 up to 0.5% JACT 9(2):229-45, 1990 confirmed

12/06Dibehenyl Fumarate 1 not in current use * Final report 03/09 -

Available from CIRDibutyl Adipate (Amended) 1 concentration not reported

in 2010; 5 to 8% in 1996IJT 25(S1):129-134,

2006 JACT15(4):295-300, 1996







(original Report);Final report 12/10

available from CIRDibutyloctyl malate 1 not in current use* IJT 34(S1): 5-17,

2015Dibutyloctyl sebacate 1 not in current use* IJT 31(S1):5-76,

2012Dibutyl Phthalate 1 up to 15% JACT 4(3):267-

303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05

Dibutyl sebacate 1 not in current use* Final report 12/10available from CIR

Di-C12-13 Alkyl Malate 1 1.0 to 36% IJT 34(S1): 5-17,2015

Di-C12 - 15 Alkyl Adipate 1 not in current use* IJT 31(S1):5-76,2012

Di-C12 - 15 Alkyl Fumarate 1 up to 5% Safety Assessment03/09 - Available

from CIRDicapryl/capryl sebacate 1 not in use at the time* IJT 31 (S1):5-76,

2012Dicapryl adipate 1 concentration not reported* IJT 31 (S1):5-76,

2012Dicapryl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics when


available from CIRDicapryl succinate 1 not in use at the time* IJT 31 (S1):5-76,

2012Dicetearyl Dimer Dilinoleate 1 up to 7% IJT 22 (S2):45-61,

2003Dicetearyl succinate 1 not in use at the time* IJT 31 (S1):5-76,

2012Dicetyl adipate 1 not in use at the time* IJT 31 (S1):5-76,

2012Dicetyl phosphate 1 safe for use in cosmetics when


available from CIRDicetyl Thiodipropionate 1 safe for use in cosmetic

formulations when formulatedto be non-irritating

JACT 11(1):25-41,1992 (original

report); JACT 29(S3): 137-150, 2010

Dichlorophene 1 IJT 23(S1):1-27 2004Diethanolamine 1 safe in the present practices

of use and concentrationwhen formulated to benon-irritating, except

do not use in cosmetic

JACT 2 (7):183-235,1983 - Final amended

report 09/11








Diethanolamine Bisulfate 1 safe in the present practicesof use and concentrationwhen formulated to benon-irritating, except


Final amended report09/11

Diethyl adipate 1 not in current use* IJT 31(S1):5-76,2012

Diethylene glycol diethyl-hexanoate/diisononanoate 1 up to 19% IJT 30(S3):228-269,2011

Diethylene Glycol Diisononanoate 1 not in current use* IJT 30(S3):228-269,2011

Diethylhexyl Adipate 1 0.6 to 14% JACT 3 (3):101-30,1984 confirmed

06/03 IJT24(S1):44-47, 2005;


Diethylhexyl Dimer Dilinoleate 1 1 IJT 22 (S2):45-61,2003

Diethylhexyl Fumarate 1 not in current use * Final report 03/09 -Available from CIR

Diethylhexyl Malate 1 0.4 to 2% IJT 34(S1): 5-17,2015

Diethylhexyl sebacate 1 not in current use* Final report 12/10available from CIR

Diethylhexyl Sodium Sulfosuccinate 1 5% IJT (S4):1-20, 1998;Final report 09/2013

available from CIRDiethylhexyl succinate 1 0.02 to 6% IJT 31 (S1):5-76,

2012Diethyl malonate 1 0.004 to 0.02% IJT 31 (S1):5-76,

2012Diethyl Phthalate 1 up to 2% JACT 4(3):267-

303, 1985confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05

Diethyl sebacate 1 1.50% IJT 31(S1):5-76,2012

Diethyl succinate 1 not in current use* IJT 31 (S1):5-76,2012

Di-HEMA Trimethylhexyl Dicarbamate 1 safe in nail enhancementproducts when skin contact isavoided; products containing

IJT 24(S5):53-100,2005









Diheptyl sodium sulfosuccinate 1 Final report 09/2013available from CIR

Diheptylundecyl adipate 1 6% Final report 12/10available from CIR

Dihexyl adipate 1 3% Final report 12/10available from CIR

Dihexyldecyl adipate 1 not in use at the time* Final report 12/10available from CIR

Dihexyldecyl sebacate 1 0.5 to 5% Final report 12/10available from CIR

Dihexyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Dihydrogenated tallow benzylmonium hectorite 1 not in use at the time* IJT 32(S4):33-40,2013

Dihydrophytosteryl octyldecanoate 1 not in current use* Final report 12/2013available from CIR

Diisoamyl Malate 1 not in current use* IJT 34(S1): 5-17,2015

Diisobutyl adipate 1 0.001 to 3% Final report 12/10available from CIR

Diisobutyl glutarate 1 not in use at the time* Final report 12/10available from CIR

Diisobutyl sodium sulfosuccinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Diisobutyl succinate 1 not in use at the time* Final report 12/10available from CIR

Diisocetyl adipate 1 not in use at the time* Final report 12/10available from CIR

Diisocetyl dodecanedioate 1 0.9 to 7% IJT 31 (S1):5-76,2012

Diisodecyl adipate 1 concentration not reported* Final report 12/10available from CIR

Diisononyl adipate 1 not in use at the time* Final report 12/10available from CIR

Diisooctyl adipate 1 not in use at the time* Final report 12/10available from CIR

Diisooctyl sebacate 1 1 to 3% Final report 12/10available from CIR

Diisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing

N-nitrosating agents

JACT 6(1):53-76,1987 confirmed12/04

IJT 25(S2), 2006







Diisopropyl Adipate 1 0.005 to 8% JACT 3 (3):101-30,1984 confirmed

06/03 IJT24(S1):44-47, 2005;


Diisopropylamine 1 safe for use in cosmeticproducts; but should not beused in products containing



12/09

Diisopropyl Dimer Dilinoleate 1 up to 53% IJT 22(S2):45-61,2003

Diisopropyl sebacate 1 0.06 to 10% IJT 31 (S1):5-76,2012

Diisostearyl adipate 1 3 to 10% Final report 12/10available from CIR

Diisostearyl Dimer Dilinoleate 1 up to 12% IJT 22(S2):45-61,2003

Diisostearyl Fumarate 1 up to 20% Final report 03/09 -Available from CIR

Diisostearyl Glutarate 1 not in current use* Final report 12/10available from CIR

Diisostearyl malate 1 0.001 to 82% IJT 34(S1): 5-17,2015

Diisostearyl sebacate 1 0.005 to 0.7% IJT 31 (S1):5-76,2012

Dilauryl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014

Dilauryl Thiodipropionate 1 safe for use in cosmeticformulations when formulated


JACT 11(1):25-41,1992 (original

report); JACT 29(S3): 137-150, 2010

Dilinoleamidopropyl dimethylamine 1 not in current use* safe in cosmetics as longas they are formulatedto be non-sensitizing,



Dimethicone 1 up to 80% in hairpreparations; up

to 24% in makeup

IJT 22(S2):11-35,2003

Dimethicone/bis-isobutyl PPG-20 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,2014

Dimethicone/bis-vinyldimethicone/silsesquioxanecrosspolymer

1 0.5 to 5% IJT 33 (S2): 65-115,2014

Dimethicone/divinyldimethicone/silsesquioxanecrosspolymer

1 0.5 to 5% IJT 33 (S2): 65-115,2014

Dimethicone/lauryl dimethicone/bis-vinyldimethiconecrosspolymer








Dimethicone/PEG-10/15 crosspolymer 1 0.03 to 3% IJT 33 (S2): 65-115,2014

Dimethicone/PEG-10 crosspolymer 1 0.50% IJT 33 (S2): 65-115,2014

Dimethicone/PEG-15 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Dimethicone/phenyl vinyl dimethicone crosspolymer 1 0.8 to 2% IJT 33 (S2): 65-115,2014

Dimethicone/PPG-20 crosspolymer 1 0.20% IJT 33 (S2): 65-115,2014

Dimethicone/titanate crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Dimethicone/vinyl dimethicone crosspolymer 1 0.003 to 46% IJT 33 (S2): 65-115,2014

Dimethicone/vinyltrimethylsiloxysilicate crosspolymer 1 0.04 to 6% IJT 33 (S2): 65-115,2014

Dimethicone Copolyol 1 up to 1% JACT 1(4):33- 54,1982 confirmed

02/03 IJT24(S1):42-44, 2005

Dimethicone crosspolymer 1 0.007 to 25% IJT 33 (S2): 65-115,2014

Dimethicone crosspolymer-3 1 0.2 to 2% IJT 33 (S2): 65-115,2014

Dimethicone PEG/PPG-7/4 Phosphate, DimethiconePEG/PPG-12/4 Phosphate, Dimethicone PEG/PPG-20/23Benzoate

3 concentration not reported* JACT 1(4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2005

Dimethicone PEG-10 Phosphate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2005

Dimethicone PEG-6 Acetate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2006

Dimethicone PEG-7 Phosphate 1 up to 0.5% JACT 1(4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2005

Dimethicone PEG-8 Adipate 1 concentration not reported* JACT 1(4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2007

Dimethicone PEG-8 Benzoate 1 up to 0.5% JACT 1 (4):33-54,1982 4 confirmed

02/03 IJT24(S1):42-44, 2005







Dimethiconol 1 0.004 to 36% IJT 33 (S2): 65- 115,2014

Dimethiconol/methylsilanol/silicate crosspolymer 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol/silica crosspolymer 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol/silsesquioxane copolymer 1 0.30% Final report 12/10available from CIR

Dimethiconol/stearyl methicone/phenyl trimethiconecopolymer

1 not in use at the time* Final report 12/10available from CIR

Dimethiconol arginine 1 concentration not reported* Final report 12/10available from CIR

Dimethiconol beeswax 1 0.8 to 0.9% Final report 12/10available from CIR

Dimethiconol behenate 1 0.50% Final report 12/10available from CIR

Dimethiconol borageate 1 0.50% Final report 12/10available from CIR

Dimethiconol candelillate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol carnaubate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol cysteine 1 0.07% Final report 12/10available from CIR

Dimethiconol dhupa butterate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol hydroxystearate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol illipe butterate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol isostearate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol kokum butterate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol lactate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol meadowfoamate 1 0.5 to 1% Final report 12/10available from CIR

Dimethiconol methionine 1 concentration not reported* Final report 12/10available from CIR

Dimethiconol mohwa butterate 1 not in use at the time* Final report 12/10available from CIR

Dimethiconol panthenol 1 0.07% Final report 12/10available from CIR

Dimethiconol sal butterate 1 not in use at the time* Final report 12/10available from CIR







Dimethiconol stearate 1 1% Final report 12/10available from CIR

Dimethoxysilyl Ethylenediaminopropyl Dimethicone 1 not in current use1 * IJT 22(S2):11-35,2003

Dimethyl adipate 1 0.20% Final report 12/10available from CIR

Dimethyl Behenamine 1 not in current use * Amended FinalReport 12-09 -

available from CIRJACT 14(3):193-95,

1995 (original report)Dimethyl Cocamine 1 not in current use * Amended Final

Report 12-09 -available from CIR

JACT 14(3):193-95,1995 (original report)

Dimethyl glutarate 1 0.5 to 15% Final report 12/10available from CIR

Dimethyl Hydrogenated Tallowamine 1 not in current use * Amended FinalReport 12-09 -


1995 (original report)Dimethyl Lauramine 1 not in current use * Amended Final



Dimethyl Myristamine 1 not in current use * Amended FinalReport 12-09 -


1995 (original report)Dimethyl Palmitamine 1 not in current use * Amended Final



Dimethyl Phthalate 1 up to 2% JACT 4(3):267-303, 1985

confirmed 11/02 IJT24(S1):34-42, 2005reconfirmed 09/05

Dimethyl Soyamine (amended) 1 not in current use * Amended FinalReport 12-09 -









Dimethyl Stearamine (amended) 1 up to 4% in non-coloringhair care products

Amended FinalReport 12-09 -


1995 (original report)Dimethyl succinate 1 not in use at the time* IJT 31 (S1):5-76,

2012Dimethyl Tallowamine 1 not in current use * Amended Final



Dimyristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Dimyristyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated


JACT 11(1):25-41,1992 (original

report); JACT 29(S3): 137-150, 2010

Dioctyl Adipate 1 up to 38% JACT 3(3):101-30,1984 confirmed

06/03 IJT24(S1):44-47, 2005

Dioctyl Dimer Dilinoleate 1 up to 12% IJT 22 (S2):45-61,2003

Dioctyldocecyl Adipate 1 concentration not reported* Final report 12/10available from CIR

Dioctyldocecyl Dimer Dilinoleate 1 up to 10% IJT 22(S2):45-61,2003

Dioctyldocecyl Dodecanedioate 1 not in use at the time* Final report 12/10available from CIR

Dioctyldocecyl Sebacate 1 3 to 8% Final report 12/10available from CIR

Dioctyldodecyl malate 1 not in current use* IJT 34(S1): 5-17,2015

Dioctyl Sodium Sulfosuccinate 1 5% IJT 17 (S4):1-20,1998

Dioleyl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating


Dioleyl Tocopheryl Methylsilanol 1 6% IJT 21 (S3):51-116,2002; Final report03/2014 available

from CIRDioscorea Villosa (Wild Yam) Root Extract 1 up to 15% of max.

2% plant solidsIJT 23(S2):49-54,

2004Dipalmitoyl cysteine 1 not in current use* safe for use in cosmetics when


available from CIRDipentaerythrityl pentaisononanoate 1 up to 13% IJT 30(S3):228-269,

2011







Diphenyl dimethicone /vinyl diphenyl dimethicone/silsesquioxane crosspolymer

1 0.1 to 7% Final report 09/12available from CIR

Diphenyl dimethicone crosspolymer 1 not in current use* Final report 09/12available from CIR

Dipotassium Aspartate 1 not in current use* IJT 32(S4):41-64,2013

Dipotassium Azelate 1 not in use at the time* IJT 31 (S1):5-76,2012

Dipotassium capryloyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Dipotassium EDTA 1 less than 0.1% IJT 21 (S2):95-142,2002

Dipotassium Glycyrrhizate 1 up to 1% IJT 26 (S2):79-112,2007

Dipotassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Dipropyl adipate 1 not in current use * Final report 12/10available from CIR

Dipropylene Glycol 1 up to 50% JACT 4(5):223-48, 1985 confirmed

02/04 IJT 25(S2),2006

Disodium azelate 1 not in current use * IJT 31 (S1):5-76,2012

Disodium C12-14 pareth-1 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium C12-14 pareth-2 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium C12-14 sec-pareth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when






disodium C12-14 sec-pareth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when









Disodium C12-15 pareth sulfosuccinate 1 safe in the present practices ofuse and concentration when









Disodium capryloyl glutamate 1 safe for use in cosmetics aslong as they are formulated



Disodium coceth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium Cocoamphodiacetate 1 0.0006 to 12% JACT 9(2):121-142,1990; re-review IJT

27(Suppl. 1):77-142,2008

Disodium Cocoamphodipropionate 1 0.008 to 15% JACT 9(2):121-142,1990; re-review IJT

27(Suppl. 1):77-142,2008

Disodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Disodium cupric citrate 1 not in current use* IJT 33 (S2): 16-46,2014

Disodium deceth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when



disodium deceth-6 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium Deceth Sulfate 1 not in current use * IJT29(S3) :151-161,2010

Disodium EDTA 1 less than 1% IJT 21(S2):95-142,2002

Disodium Fumarate 1 not in current use * Final report 03/09 -Available from CIR

Disodium Glycyrrhizate 1 not in current use * IJT 26(S2):79-112,2007

Disodium hydrogenated tallow glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Disodium laneth-5 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium laureth-12 sulfosuccinate 1 safe in the present practices ofuse and concentration when















Disodium laureth sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium Lauriminodipropionate 1 not in current use * IJT 32 (S3):49-55,2013

Disodium lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Disodium Lauryl phosphate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Disodium malyl tyrosinate 1 safe for use in cosmetics whenformulated to be non-irritating


Disodium N-lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Disodium oleth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Disodium oleyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Disodium sebacate 1 not in current use * IJT 31 (S1):5-76,2012

Disodium stearoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Disodium Succinate 1 0.0005 to 0.4% IJT 31 (S1):5-76,2012

Disodium Succinoyl Glycyrrhetinate 1 not reported * IJT 26(S2):79-112,2007

Disodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Disperse Black 9 1 up to 0.5% JACT 5(3):205-23,1986 confirmed

12/06Disperse Blue 1 1 up to 1% JACT 14(6):433-51,

1995; confirmed03/2011

Disperse Blue 7 1 IJT 26(S2):65-77,2007

Disperse Violet 1 1 up to 1% JACT 10(1):103-11,1991

Disperse Yellow 3 1 JACT 15(4):301-10,1996

Disteardimonium hectorite 1 0.04 to 28% IJT 32 (S4):33-40,2013

Distearyl citrate 1 not in current use * IJT 33 (S2): 16-46,2014

Distearyl Thiodipropionate 1 safe for use in cosmeticformulations when formulated


JACT 11(1):25-41,1992 (original







report); JACT 29(S3): 137-150, 2010

Di-t-Butylhydroquinone 1 JACT 15(4):311-9,1996

Ditridecyl Adipate 1 not in current use * Final report 12/10available from CIR

Ditridecyl Dimer Dilinoleate 1 not in current use * IJT 22(S2):45-61,2003

Ditridecyl sodium sulfosuccinate 1 not in current use * safe for use in cosmetics whenformulated to be non-irritating


Ditridecyl Thiodipropionate (dialkyl esters) 1 safe for use in cosmeticformulations when formulated


JACT 11(1):25-41,1992 (original

report); JACT 29(S3): 137-150, 2010

Divinyldimethicone/dimethicone crosspolymer 1 0.007 to 0.7% Final report 09/12available from CIR

DMDM Hydantoin 1 up to 1% JACT 7(3):245-77,1988 confirmed

09/05Dmethicone/polyglycerin-3 crosspolymer 1 concentration not reported* IJT 33 (S2): 65-115,

2014Dodecanedioic acid 1 not in current use * IJT 31 (S1):5-76,

2012Dodecylhexadecyl-trimonium chloride 1 safe when formulated


(2012)Drometrizole 1 0.07% IJT 27(S2): 63-75,

2008 JACT5(5):455-70, 1986

(original report)EDTA 1 up to 2% IJT 21(S2):95-142,

2002Elaeis (Palm) Fruit Oil 1 not in current use* Final report 03/11

available from CIRElaeis Guineensis (Palm) Butter 1 not in current use* Final report 03/11

available from CIRElaeis Guineensis (Palm) Kernel Oil 1 0.05 to 23% Final amended report

03/11 availablefrom CIR; IJT 19

(S2):7-28, 2000(original)

Elaeis Guineensis (Palm) Oil 1 up to 2% Final amended report03/11 available

from CIR; IJT 19(S2):7-28, 2000

(original)Elaeis Oleifera Kernel Oil 1 Final report 03/11

available from CIR







Elastin Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Emulsifying Wax N.F. 1 up to 21% JACT 3(3):43- 99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Erucyl Arachidate 1 not in current use* safe when formulatedto be non-irritating


Erucyl Erucate 1 not in current use* safe when formulatedto be non-irritating


Erucyl Oleate 1 not in current use* safe when formulatedto be non-irritating


Erythorbic Acid 1 up to 1% IJT 18(S3):1-26,1999

Ethanolamine (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


Final amended report03/12 available

from CIR; JACT2(7):183-235, 1983

(original report)

Ethanolamine HCl 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


Final amended report03/12 available

from CIR; JACT2(7):183-235, 1983

(original report)

Ethanolamine Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes



IJT 28(S3):68-133,2009

Ethoxydiglycol 1 up to 80% JACT 4(5):223-48,1985 confirmed

02/04 IJT 25(S2),2006

Ethoxyethanol 1 reproductive &developmental toxicity

IJT 21(S1):9-62,2002

Ethoxyethanol Acetate 1 reproductive &developmental toxicity

IJT 21(S1):9-62,2002







Ethoxyethyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Ethyl Acetate 1 greater than 50% JACT 8(4):681-705,1989 confirmed

08/06Ethyl Benzoate 1 0.0008 to 0.01% IJT 31(3):342 -372

(2012)Ethylcellulose (amended) 1 up to 4% Amended safety

assessment 03/09Ethyl citrates 1 0.5 to 1% in rinse-off IJT 33 (S2): 16-46,

2014Ethylene/Acrylic Acid/VA Copolymer 1 safe for use when

formulated to avoid irritationIJT 21(S3):1-50,

2002Ethylene/Acrylic Acid Copolymer 1 safe for use when


2002Ethylene/Calcium Acrylate Copolymer 1 safe for use when


2002Ethylene/Magnesium Acrylate Copolymer 1 safe for use when


2002Ethylene/Methacrylate Copolymer 1 safe for use when


2002Ethylene/octene copolymer* 1 safe as used Final report 06/2015

available from CIREthylene/propylene/styrene copolymer 1 Final report 09/2014

available from CIREthylene/propylene copolymer 1 safe as used Final report 06/2015

available from CIREthylene/Sodium Acrylate Copolymer 1 safe for use when


2002Ethylene/Zinc Acrylate Copolymer 1 safe for use when


2002Ethylene Glycol Dimethacrylate 1 safe in nail enhancement

products when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Ethyl Ester of PVM/MA Copolymer (amended) 1 up to 30% Amended FinalReport 06/09

Available from CIR








Ethyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Ethyl Glycolate and Ethyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998

Ethyl Hexanediol 1 5% in 1984, butnot in current use *


09/09Ethylhexyl Adipate/Palmitate/Stearate 1 not in current use* safe for use in cosmetics when


available from CIREthylhexyl Benzoate 1 3 to 4% IJT 31(3):342-372

(2012)Ethylhexyl C10-40 Isoalkyl Acidate 1 not in current use* safe for use in cosmetics when


available from CIREthylhexyl Cocoate (amended) 1 up to 41% safe for use in cosmetics when

formulated to be non-irritatingIJT 30(S1):5S-16S;


Ethylhexyl Ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating


Ethylhexylglycerin 1 IJT 32 (S3): 5-21,2013

Ethylhexyl Hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating


Ethylhexyl isononanoate 1 up to 75% safe for use in cosmetics whenformulated to be non-irritating

IJT 30(S3):228-269,2011; final report03/2013 available

from CIREthylhexyl Isopalmitate 1 safe for use in cosmetics when


available from CIREthylhexyl Isostearate 1 safe for use in cosmetics when


available from CIREthylhexyl Laurate 1 safe for use in cosmetics when


available from CIREthylhexyl Myristate 1 not in use at the time* safe for use in cosmetics when

formulated to be non-irritatingIJT

29(S3) :162-186,2010;final report 03/2013available from CIR







Ethylhexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Ethylhexyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Ethylhexyl Olivate 1 safe for use in cosmetics whenformulated to be non-irritating


Ethylhexyl Palmitate 1 up to 46% safe for use in cosmetics whenformulated to be non-irritating


09/01; final report03/2013 available

from CIREthylhexyl Pelargonate 1 2 to 25% safe for use in cosmetics when


available from CIR;Final report 03/2013

available from CIREthylhexyl Salicylate 1 safe when formulated to



IJT 22(3):1-108

Ethylhexyl Stearate 1 up to 11% safe for use in cosmetics whenformulated to be non-irritating


06/03; final report03/2013 available

from CIREthyl Methacrylate (Amended) 1 safe as used when application

is accompanied by directionsto avoid skin contact because

of the sensitizing potential

IJT 21(S1):63-79,2002 JACT 14(6):

452-67, 1995(Original Report)

Ethyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010

Ethylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4): 1-82,2008 JACT


Ethyl Ricinoleate 1 not in current use * IJT 26(S3): 31-772007

Ethyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes


hairdressers should avoid

IJT 28(S3):68-133,2009







skin contact and minimizeconsumer skin exposure

Euphorbia Cerifera (Candelilla) Wax 0 up to 27% JACT 3(3):1-41,1984 confirmed

06/03 IJT24(S1):48-52, 2005

Euterpe Oleracea Fruit Oil 1 0.00001 to 0.5% Final report 03/11available from CIR

Euterpe Oleracea sterols 1 Final report 12/2013available from CIR

Ferric citrate 1 0.5% in rinse-off;concentration not

reported for leave- on

IJT 33 (S2): 16-46,2014

Ferrous Fumarate 1 up to 0.0003% Final report 03/09 -Available from CIR

Fibroin 1 Final report 12/2015available from CIR

Formaldehyde 1 1 safe for use in cosmeticswhen formulated to

ensure use at the minimaleffective concentration,but in no case should theformalin concentration

exceed 0.2% (w/w), whichwould be 0.074% (w/w)

calculated as formaldehyde or0.118% (w/w) calculated as

IJT 32(Suppl.4):5-32, 2013; JACT

3(3):157-84, 1984confirmed 09/03 IJT

25(S2): 1-89, 2006

Formic Acid 1 less than or equal to64ppm of the free acid

IJT 16(S3):221-34,1997; Final report01/2014 available

from CIRFragaria Anannassa (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11

available from CIRFragaria Chiloensis (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11

available from CIRFragaria Vesca (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11

available from CIRFragaria Virginiana (Strawberry) Seed Oil 1 not in use at the time* Final report 03/11

available from CIRFructose 1 Final report 03/2014

available from CIRFucose 1 not in current use* Final report 03/2014

available from CIRFullers Earth 1 up to 50% IJT 22(S1):37-102,

2003Fumaric Acid 1 up to 5% Final report 03/09 -

Available from CIR







Galactoarabinan 1 Final report 09/2015available from CIR

Galactomannans (see CIR report of the same name) Final report 03/12available from CIR

Galactose 1 not in current use* Final report 03/2014available from CIR

Galactosyl Fructose 1 not in current use* Final report 03/2014available from CIR

Galacturonic Acid 1 not in current use* Final report 03/2014available from CIR

Garcinia Indica Seed Butter 1 0.1 to 2% Final report 03/2011available from CIR

Garcinia mangostana amino acids 1 not in current use* IJT 33(S4):5-12,2014

Gellan Gum 1 0.0004 to 0.5% Final report 09/12available from CIR

Gevuina Avellana Oil 1 0.002 to 0.2% Final report -3/11available from CIR

Gevuina Avellana Seed Oil 1 0.1 to 2% Final report -3/11available from CIR

Ghatti Gum 1 Final report 09/2015available from CIR

Glucomannan 1 Final report 09/2015available from CIR

Gluconic Acid 1 Final report 03/2014available from CIR

Glucose 1 Final report 03/2014available from CIR

Glucose Glutamate 1 IJT 19(S1):11-12,2000

Glutamic Acid 1 0.000004 to 2% IJT 32(S4):41-64,2013

Glutamine 1 0.002 to 0.005% IJT 32(S4):41-64,2013

Glutaral 1 less than 0.5% for rinse-off; but should not be usedin products intended to beaerosolized (insufficient

data to support safetyin leave-on products)

JACT 15(2):98-139,1996

Glutaric acid 1 not in current use * IJT 31 (S1):5-76,2012

Glycerin 1 Final report 12/2014available from CIR

Glyceryl/Sorbitol Oleate/Hydroxystearate 1 not in current use * IJT 23(S2):55-94,2004







Glyceryl Acetate 1 Final report 12/2015available from CIR

Glyceryl Adipate 1 IJT 23(S2):55-94,2004;


Glyceryl Alginate 1 IJT 23 (S2):55-94,2004; Final report


Glyceryl Allyl Ether 1 not in current use* IJT 32 (S3): 5-21,2013

Glyceryl Arachidate 1 IJT 23(S2):55-94,2004;


Glyceryl Arachidonate 1 IJT 23(S2):55-94,2004

Glyceryl Behenate 1 IJT 23(S2):55-94,2004;


Glyceryl Caprate 1 IJT 23(S2):55-94,2004;


Glyceryl Caprylate 1 IJT 23(S2):55-94,2004;


Glyceryl Caprylate/Caprate 1 IJT 23(S2):55-94,2004;


Glyceryl Capryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013

Glyceryl Citrate/Lactate/Linoleate/Oleate 1 IJT 23(S2):55-94,2004;


Glyceryl Cocoate 1 IJT 23 (S2):55-94,2004; Final report


Glyceryl Cocoate/Citrate/Lactate 1 Final report 12/2015available from CIR

Glyceryl Collagenate 1 not in current use * IJT 23(S2):55-94,2004







Glyceryl Diarachidate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content

of 1,2-diesters is nothigh enough to induceepidermal hyperplasia

IJT 26(S3):1-30,2007

Glyceryl Dibehenate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dierucate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dihydroxystearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Diisopalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Diisostearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007







Glyceryl Dilaurate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dilinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dimaltodextrin 1 Final report 09/2015available from CIR

Glyceryl Dimyristate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 23(S2):55-94,2004; IJT

26(S3):1-30, 2007

Glyceryl Dioleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dipalmitate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Dipalmitoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content

of 1,2-diesters is not

IJT 26(S3):1-30,2007







high enough to induceepidermal hyperplasia

Glyceryl Diricinoleate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Distearate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Erucate 1 IJT 23 (S2):55-94,2004; Final report


Glyceryl Ethylhexanoate 1 Final report 12/2015available from CIR

Glyceryl Ethylhexanoate/Stearate/Adipate 1 Final report 12/2015available from CIR

Glyceryl Glycyrrhetinate 1 not in current use * IJT 26(S2):79-112,2007

Glyceryl Heptanoate 1 Final report 12/2015available from CIR

Glyceryl Hydrogenated Rapeseedate 1 Final report 12/2015available from CIR

Glyceryl Hydrogenated Rosinate 1 IJT 23(S2):55-94,2004;


Glyceryl Hydrogenated Soyate 1 IJT 23(S2):55-94,2004; Final report12/2015 available

from CIRGlyceryl Hydroxystearate 1 IJT 23 (S2):55-94,

2004; Final report12/2015 available

from CIRGlyceryl Isopalmitate 1 IJT 23(S2):55-94,


from CIR







Glyceryl Isostearate 1 IJT 23(S2):55- 94,2004; Final report12/2015 available

from CIRGlyceryl Isostearate/Myristate 1 not in current use * IJT 23(S2):55-94,

2004Glyceryl Isostearates 1 not in current use * IJT 23(S2):55-94,

2004Glyceryl Isotridecanoate/Stearate/Adipate 1 IJT 23(S2):55-94,


from CIRGlyceryl Lanolate 1 IJT 23(S2):55-94,


from CIRGlyceryl Laurate 1 IJT 23(S2):55-94,


from CIRGlyceryl Laurate/Oleate 1 IJT 23(S2):55-94,


from CIRGlyceryl Laurate SE 1 IJT 23(S2):55-94,


from CIRGlyceryl Lauryl Ether 1 IJT 32 (S3): 5-21,

2013Glyceryl Linoleate 1 IJT 23(S2):55- 94,


from CIRGlyceryl Linolenate 1 IJT 23(S2):55- 94,


from CIRGlyceryl Montanate 1 IJT 23(S2):55-94,


from CIRGlyceryl Myristate 1 up to 6% IJT 23(S2):55-94,

2004Glyceryl Oleate 1 JACT 5(5):391- 413;








Glyceryl Oleate/Elaidate 1 IJT 23 (S2):55-94,2004; Final report12/2015 available

from CIRGlyceryl Oleate SE 1 IJT 23(S2):55-94,


from CIRGlyceryl Olivate 1 Final report 12/2015

available from CIRGlyceryl Palmitate 1 IJT 23(S2):55-94,


from CIRGlyceryl Palmitate/Stearate 1 IJT 23(S2):55-94,


from CIRGlyceryl Palmitate Lactate 1 safe as cosmetic ingredients

in the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Palmitoleate 1 IJT 23(S2):55-94,2004; Final report12/2015 available

from CIRGlyceryl Pentadecanoate 1 IJT 23(S2):55-94,


from CIRGlyceryl Polyacrylate 1 up to 2% IJT 23(S2):55 -94,

2004Glyceryl Ricinoleate 1 IJT 26(S3) 2007;

JACT 7(6):721-39,1988 (original

report); Final report12/2015 available

from CIRGlyceryl Ricinoleate SE 1 IJT 26(S3) 2007;


Glyceryl Rosinate 1 IJT 23(S2):55-94,2004; Final report








Glyceryl Sesquioleate 1 not in current use * IJT 23(S2):55-94,2004

Glyceryl Starch 1 Final report 09/2015available from CIR

Glyceryl Stearate 1 JACT 1(4):169-92,1982; Final report12/2015 available

from CIRGlyceryl Stearate/Acetate 1 up to 7% IJT 23 (S2):55-94,

2004Glyceryl Stearate/Malate 1 Final report 12/2015

available from CIRGlyceryl Stearate/Maleate 1 not in current use * IJT 23(S2):55-94,

2004Glyceryl Stearate Citrate 1 safe as cosmetic ingredients



IJT 26(S3):1-30,2007

Glyceryl Stearate Diacetate 1 not in current use * IJT 20(S4):61-94,2001

Glyceryl Stearate Lactate 1 safe as cosmetic ingredientsin the practices of use andconcentration as describedin the safety assessment,provided that the content


IJT 26(S3):1-30,2007

Glyceryl Stearate SE 1 JACT 1(4):169-92,1982; Final report12/2015 available

from CIRGlyceryl Stearate Succinate 1 safe as cosmetic ingredients



IJT 26(S3):1-30,2007

Glyceryl Tallowate 1 IJT 23(S2):55-94,2004; Final report








Glyceryl Thioglycolate (amended) 1 safe in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair

products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);

hairdressers should avoid skincontact and minimize cons

IJT 28(S3):68-133,2009 JACT


Glyceryl Thiopropionate 1 not in current use * IJT 23(S2):55-94,2004

Glyceryl Triacetyl Hydroxystearate 1 9% IJT 20 (S4):61-94,2001

Glyceryl Triacetyl Ricinoleate 1 8% IJT 20 (S4):61-94,2001

Glyceryl Undecylenate 1 IJT 23 (S2):55-94,2004; Final report12/2015 available

from CIRGlycine 1 0.0005 to 4% IJT 32(S4):41-64,

2013Glycine max (soybean) polypeptide 1 Final report 09/2015

available from CIRGlycine Soja (Soybean) Oil 1 .0002 to 95% Final report 03/11

available from CIRGlycine Soja (Soybean) Oil Unsaponifiables 1 0.0001 to 0.2% Final report 03/11

available from CIRGlycine soja (soybean) peptide* 1 Final report 09/2015

available from CIRGlycine soja (soybean) protein 1 Final report 09/2015

available from CIRGlycine Soja (Soybean) Sterols 1 Final report 12/2013

available from CIRGlycol Dimethacrylate/Vinyl Alcohol Crosspolymer 1 safe in the present practices of



Glycol Distearate 1 up to 9% JACT 1(2):1-11,1982 confirmed

09/01 IJT22(S1):1-35, 2003

Glycol HEMA-Methacrylate (aka Ethylene GlycolDimethacrylate )

1 safe in nail enhancementproducts when skin contact isavoided; products containing


to avoid skin contact

IJT 24(S5):53-100,2005







because of the sensitizingpotential of methacrylates

Glycolic Acid (e.g. Alpha Hydroxy Acids) 1 Glycolic and Lactic Acid,their common salts and their





IJT 17(S1):1-242,1998

Glycol Ricinoleate 1 not in current use * IJT 26(S3):31-77,2007

Glycol Stearate 1 up to 6% JACT 1(2):1-11,1982 confirmed

09/01 IJT22(S1):1-35, 2003

Glycol Stearate SE 1 up to 12% JACT 1(2):1-11,1982 confirmed

09/01 IJT22(S1):1-35, 2003

Glycyrrhetinic Acid 1 up to 2% IJT 26(S2):79- 112,2007

Glycyrrhetinyl Stearate 1 not in current use * IJT 26(S2):79-112,2007

Glycyrrhiza Glabra (Licorice) Leaf Extract 1 concentration not reported* Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Rhizome/Root 1 0.0001 to 0.4% Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root 1 0.0001 to 0.4% Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root Extract 1 0.0001 to 0.4% Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root Extract [polyol soluble] 1 0.0001 to 0.06% Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root Juice 1 not in current use* Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root Powder 1 not in current use* Final report 09/08available from CIR

Glycyrrhiza Glabra (Licorice) Root Water 1 not in current use* Final report 09/08available from CIR

Glycyrrhiza Inflata Root Extract 1 not in current use* Final report 09/08available from CIR

Glycyrrhiza Inflata Root Extract [polyol soluble] 1 0.0001 to 15% Final report 09/08available from CIR







Glycyrrhiza Uralensis (Licorice) Root Extract 1 not in current use* Final report 09/08available from CIR

Glycyrrhizic Acid 1 up to 0.1% IJT 26(S2):79- 112,2007

Glyoxal (Amended) 1 1.25% in products intendedto be applied to the nail

JACT 14(5):348-63,1995 IJT

19(1):13-27, 2000Gossypium (Cotton) Seed Oil 1 IJT 20(S2):21-29,

2001Gossypium Herbaceum (Cotton) Seed Oil 1 0.004 to 32% Final report 03/11

available from CIRGrape Seed Oil PEG-8 esters 1 safe for use in cosmetics when


2014Guar hydroxypropyltrimonium chloride 1 0.005 to 2% IJT 34(S1): 35-65,

2015Guizotia Abyssinica Seed Oil 1 not in use at the time* Final report 03/11

available from CIRHair keratin amino acid 1 IJT 33(S4):5-12,

2014Hazel Seed Oil PEG-8 Esters 1 safe for use in cosmetics when


2014HC Blue No. 1 1 carcinogenicity JACT 13(5):344 -60,

1994HC Blue No. 2 1 2% in a hair dye

(diluted in use to 1%)JACT 13(5):361-73,1994; confirmed IJT30(Suppl. 2):98-99,

2011HC Orange No. 1 1 safe for use in hair

dyes up to 3%IJT 17(S4):21-38,

1998HC Red No. 1 1 0.5% JACT 15(4):320-36,

1996; confirmed06/2011

HC Red No. 3 1 safe as used in hair dyes;but should not be usedin products containingN-nitrosating agents

JACT 11(4):509-19,1992

HC Red No. 7 1 up to 1% Final Report 06/06Available from CIR

HC Yellow No. 2 1 up to 3% JACT 13(3):157-66,1994 confirmed

12/08HC Yellow No. 4 1 less than or equal to 3% IJT 17(S4):39-70,

1998HC Yellow No. 5 1 up to 1.6% IJT 26(S2):113- 124,

2007Hectorite 1 100% in a skin cleanser;

up to 15% in other usesIJT 22(S1):37-102,

2003







HEDTA 1 concentration not reported * IJT 21 (S2):95-142,2002

Helianthus Annuus (Sunflower) Seed Oil 1 0.000007 to 96% Final report 03/11available from CIR

Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables 1 0.005 to 2% Final report 03/11available from CIR

HEMA 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

HEMA Acetoacetate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Heptyl undecylenate 1 safe as used in cosmeticswhen formulated



Heptylundecyl hydroxystearate 1 safe as used in cosmeticswhen formulated



Hexacosyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Hexadecyl D-glucoside 1 safe as used in cosmeticswhen formulated


IJT 32 (S3): 22-48,2013

Hexamidine 1 safe at concentrationsless than or equal to 0.1%

IJT 26(S3) 2007

Hexamidine Diisethionate 1 safe at concentrationsless than or equal to 0.1%

IJT 26(S3) 2007

Hexapeptide-12 1 not in current use* Final report 06/2014available from CIR

Hexyldeceth-2 1 safe for use in cosmeticswhen formulated


IJT32(S2):169-244(2012)

Hexyldeceth-20 1 safe for use in cosmeticswhen formulated


IJT32(S2):169-244(2012)

Hexyldecyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)







Hexyldecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl isostearate 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl oleate 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl palmitate 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldecyl stearyl 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldodecyl/ octyldecyl hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating


Hexyldodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Hexylene Glycol 1 up to 6% JACT 4(5):223-48,1985 confirmed

02/04 IJT 25(S2),2006

Hexyl isostearate 1 safe as used in cosmeticswhen formulated



Hexyl laurate 1 safe as used in cosmeticswhen formulated



Hexyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Hexyl Methicone 1 not in current use * IJT 22 (S2):11-35,2003

Hippophae Rhamnoides Fruit Oil 1 6 to 35% Final report 03/11available from CIR

Hippophae Rhamnoides Oil 1 0.2 to 0.7 Final report 03/11available from CIR







Hippophae Rhamnoides Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Histidine 1 0.00009 to 0.05% IJT 32(S4):41-64,2013

Histidine HCl 1 0.00003 to 0.07% IJT 32(S4):41-64,2013

Human Placental Enzymes 1 if used, should not deliverany metabolic/endocrineactivity, and they must be

free of detectable pathogenicviruses or infectious agents

IJT 21(S1):81-91,2002

Human Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be


IJT 21(S1):81-91,2002

Human Placental Protein 1Human Umbilical Extract 1 if used, should not deliver

any metabolic/endocrineactivity, and they must be


IJT 21(S1):81-91,2002

Hyaluronic Acid 1 up to 1% IJT 28 (1): 5-67,2009

Hydrated Silica 1 up to 34% Final Report 09/09available from CIR

Hydrogenated Adansonia Digitata Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Apricot Kernel Oil 1 concentration not reported* Final report 03/11available from CIR

Hydrogenated Apricot Kernel Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Argania Spinosa Kernel Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Avocado Oil 1 up to 5% Final report 03/11available from CIR

Hydrogenated Black Currant Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Butadiene/Isoprene/Styrene Copolymer 1 not in current use* Final report 09/2014available from CIR

Hydrogenated Butylene/Ethylene/Styrene Copolymer 1 Final report 09/2014available from CIR

Hydrogenated Camelina Sativa Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Camellia Oleifera Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Hydrogenated Canola Oil 1 concentration not reported* Final report 03/11available from CIR







Hydrogenated Castor Oil 1 up to 39% IJT 26 (S3):31-77,2007

Hydrogenated Castor Oil Behenyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated castor Oil cetyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated castor oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Hydrogenated castor oil stearyl esters 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Cocoglycerides (amended) 1 up to 31% IJT 30(S1):5S-16SHydrogenated Coconut Acid (amended) 1 6 to 10% IJT 30(S1):5S-16S;


Hydrogenated Coconut Oil (amended) 1 0.001 to 50% IJT 30(S1):5S-16S;JACT 5(3):103-21,

1986 (original report)Hydrogenated Cottonseed Glyceride 1 safe as used in cosmetic

products, provided thatestablished and imposed limits

on gossypol, heavy metals,and pesticide concentrations

are not exceeded.

IJT 20(S2):21-29,2001

Hydrogenated Cottonseed Oil 1 0.001 to 24% Final report 03/11available from CIR

Hydrogenated Cranberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Dimer Dilinoleth-20 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(3):342-372(2012)


IJT 31(3):342-372(2012)


IJT 31(3):342-372(2012)


IJT 31(3):342-372(2012)


IJT 31(3):342-372(2012)

Hydrogenated Ethylene/ Propylene/Styrene Copolymer 1 Final report 09/2014available from CIR

Hydrogenated Ethylhexyl olivate 1 safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Ethylhexyl sesamate 1 safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Evening Primrose Oil 1 concentration not reported* Final report 03/11available from CIR

Hydrogenated Grapeseed Oil 1 0.3 to 0.5% Final report 03/11available from CIR







Hydrogenated Grapesuit Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Grapesuit Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Hazelnut Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Isocetyl olivate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Isopropyl Jojobate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Jojoba Oil (amended) 1 up to 31% Amended FinalReport 09/08 -

available from CIRHydrogenated Kukui Nut Oil 1 not in use at the time* Final report 03/11

available from CIRHydrogenated Laneth-20 1 safe for use in cosmetics when

formulated to be non-irritatingIJT 31(3):342-372

(2012)Hydrogenated Laneth-25 1 safe for use in cosmetics when


(2012)Hydrogenated Laneth-5 1 safe for use in cosmetics when


(2012)Hydrogenated Lanolin 1 up to 10% JEPT 4(4):63 -92,


24(S1):2-10, 2005Hydrogenated Lard 1 lead 0.1ppm; arsenic 3ppm;

mercury 1ppm; total PCB/pesticide contamination40ppm with 10ppm for

any specific residue

IJT 20(S2):57-64,2001

Hydrogenated Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/

pesticide contamination40ppm with 10ppm for


IJT 20(S2):57-64,2001

Hydrogenated Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/



IJT 20(S2):57-64,2001

Hydrogenated Lecithin 1 safe as used. IJT 20(S1):21-45,2001; Final report03/2015 available

from CIRHydrogenated Lime Seed Oil 1 not in use at the time* Final report 03/11

available from CIRHydrogenated Lime Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11

available from CIR







Hydrogenated Lysolecithin* 1 safe as used Final report 03/2015available from CIR

Hydrogenated Lysophosphatidylcholine* 1 safe as used Final report 03/2015available from CIR

Hydrogenated Macadamia Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Meadowfoam Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Olive Oil 1 0.0005 to 12% Final report 03/11available from CIR

Hydrogenated Olive Oil Unsaponifiables 1 0.05 to 5% Final report 03/11available from CIR

Hydrogenated Orange Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Orange Seed Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Palm/Palm Kernel Oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Hydrogenated Palm Acid 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Palm Kernel Oil 1 0.4 to 13% Final report 03/11available from CIR

Hydrogenated Palm Oil 1 0.2 to 30% IJT 19 (S2):7-28,2000; Final amended


Hydrogenated Palmtrimonium chloride 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Hydrogenated Passiflora Edulis Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Peach Kernel Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Peanut Oil 1 2 to 5% IJT 20 (S2):65-77,2001; final amended


Hydrogenated Phosphatidylcholine* 1 safe as used Final report 03/2015available from CIR

Hydrogenated Pistachio Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated poly(C6-12 olefin) 1 safe as used Final report 06/2015available from CIR









Hydrogenated polybutene* 1 safe as used Final report 06/2015available from CIR

Hydrogenated polydecene 1 safe as used Final report 06/2015available from CIR

Hydrogenated polydodecene* 1 safe as used Final report 06/2015available from CIR

Hydrogenated polyisobutene 1 safe as used Final report 06/2015available from CIR

Hydrogenated Polyisobutene 1 up to 96% IJT 27 (S4): 83-106,2008

Hydrogenated Potato Starch 1 Final report 09/2015available from CIR

Hydrogenated Pumpkin Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Punica Granatum Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Rapeseed Oil 1 0.3 to 4% Final report 03/11available from CIR

Hydrogenated Raspberry Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Rice Bran Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Rice Bran Wax 1 concentration not reported* IJT 25(S2):91-120,2006

Hydrogenated Rosa Canina Fruit Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Safflower Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Sesame Seed Oil (amended) 1 not in current use* JACT 12(3):261-77,1993 (original

report); IJT 30 (1):40-53, 2011

Hydrogenated Shea Butter 1 up to 1% Final report 03/11available from CIR

Hydrogenated Soybean Oil 1 0.001 to 42% Final report 03/11available from CIR

Hydrogenated Starch Hydrolysate 1 Final report 09/2015available from CIR

Hydrogenated Styrene/Butadiene Copolymer 1 Final report 09/2014available from CIR

Hydrogenated Styrene/Isoprene Copolymer 1 Final report 09/2014available from CIR

Hydrogenated Sunflower Seed Oil 1 6 to 35% Final report 03/11available from CIR

Hydrogenated Sweet Almond Oil 1 up to 0.5% Final report 03/11available from CIR







Hydrogenated Sweet Almond Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Tallowalkonium Bentonite* 1 safe as used when formulatedto be non-irritating


Hydrogenated tallowamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Hydrogenated Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Hydrogenated Talloweth-12 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(3):342-372(2012)

Hydrogenated Talloweth-25 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(3):342-372(2012)

Hydrogenated Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed

06/06Hydrogenated Tallow Glycerides 1 up to 25% JACT 9(2):153-64,

1990 confirmed06/06

Hydrogenated Tallowtrimonium chloride 1 safe when formulatedto be non-irritating

IJT 31(S3): 296-341(2012)

Hydrogenated Vegetable Oil 1 0.0004 to 60% Final report 03/11available from CIR

Hydrogenated Wheat Germ Oil 1 not in use at the time* Final report 03/11available from CIR

Hydrogenated Wheat Germ Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Hydrolyzed Beta-glucan 1 not in current use* Final report 09/12available from CIR

Hydrolyzed caesalpinia spinosa gum 1 0.002 to 0.4% IJT 34(S1): 35-65,2015

Hydrolyzed camellia sinensis leaf 1 not in current use* Final report 09/2014available from CIR

Hydrolyzed camellia sinensis seed extract 1 Final report 09/2014available from CIR

hydrolyzed carrageenan 1 Final report 09/2015available from CIR

Hydrolyzed Cellulose Gum 1 not in use at the time* Amended safetyassessment03/09 -

Available from CIRHydrolyzed ceratonia siliqua gum extract 1 not in current use* IJT 34(S1): 35-65,

2015







Hydrolyzed Citrus Aurantium Dulcis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Hydrolyzed Collagen 1 up to 6% JACT 4(5)199- 221,1985 confirmed

06/04 IJT 25(S2),2006

Hydrolyzed Collagen PG-propyl dimethiconol 1 not in use at the time* Final report 03/11available from CIR

Hydrolyzed Corn Protein 1 not in use at the time* IJT 30 (S1): 17-39,2011

Hydrolyzed Corn Starch 1 not in use at the time* IJT 30 (S1): 17-39,2011

Hydrolyzed Corn Starch Hydroxyethyl Ether 1 Final report 09/2015available from CIR

Hydrolyzed Corn Starch Octenylsuccinate 1 Final report 09/2015available from CIR

Hydrolyzed Fibroin 1 Final report 12/2015available from CIR

Hydrolyzed Furcellaran 1 Final report 09/2015available from CIR

Hydrolyzed ginseng root 1 not in current use* Final report 09/12available from CIR

Hydrolyzed ginseng root extract 1 not in current use* Final report 09/12available from CIR

Hydrolyzed ginseng saponins 1 not in current use* Final report 09/12available from CIR

Hydrolyzed grape fruit 1 not in current use* Tentative report06/12 available from

CIRHydrolyzed grape skin 1 not in current use* Tentative report


Hydrolyzed guar 1 0.03 to 3% IJT 34(S1): 35-65,2015

Hydrolyzed Human Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be


IJT 21(S1):81-91,2002

Hydrolyzed Jojoba Esters (amended) 1 up to 2% Amended FinalReport 09/08 -

available from CIR







Hydrolyzed Oat Flour 1 safe when formulatedto be non- sensitizing


Hydrolyzed Oat Protein 1 safe when formulatedto be non- sensitizing


Hydrolyzed Oats 1 safe when formulatedto be non- sensitizing


Hydrolyzed Pectin 1 Final report 09/2015available from CIR

Hydrolyzed Phospholipids* 1 safe as used Final report 03/2015available from CIR

Hydrolyzed Placental Protein 1 if used, should not deliverany metabolic/endocrineactivity, and they must be


IJT 21(S1):81-91,2002

Hydrolyzed Rhizobian Gum 1 0.4 to 3% Final report 09/12available from CIR

Hydrolyzed Rice Bran Extract 1 up to 0.0004% These rice derivedingredients as used in

products should not containsignificant levels of pesticide

residues or heavy metals

IJT 25(S2):91-120,2006

Hydrolyzed Rice Bran Protein 1 not in current use* These rice derivedingredients as used in



IJT 25(S2):91-120,2006

Hydrolyzed Rice Extract 1 up to 0.3% These rice derivedingredients as used in



IJT 25(S2):91-120,2006

Hydrolyzed Rice Protein 1 up to 2% These rice derivedingredients as used in



IJT 25(S2):91-120,2006

Hydrolyzed Sclerotium gum 1 1% Final report 09/12available from CIR

Hydrolyzed Sericin 1 Final report 12/2015available from CIR

Hydrolyzed Silk 1 Final report 12/2015available from CIR

Hydrolyzed soymilk protein 1 Final report 09/2015available from CIR

Hydrolyzed soy protein 1 Final report 09/2015available from CIR







Hydrolyzed soy protein extract 1 Final report 09/2015available from CIR

Hydrolyzed Soy Starch 1 Final report 09/2015available from CIR

Hydrolyzed Starch 1 Final report 09/2015available from CIR

Hydrolyzed Triticum Spelta Starch 1 Final report 09/2015available from CIR

Hydrolyzed Wheat Gluten 1 safe as used in cosmeticswhen formulated to restrict

peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.


Hydrolyzed Wheat Protein 1 safe as used in cosmeticswhen formulated to restrict

peptides to a weight-averagemolecular weight (MW) of3,500 daltons (Da) or less.


Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR

Hydroquinone 1 1 safe at concentrations ofless than or equal to 1%

for cosmetic formulationsdesigned for discontinuous,

brief use followed byrinsing from the skin and

hair. Hydroquinone is safefor use in nail adhesives

and in artificial nailcoatings, as a polymeriza

Unsafe for use in otherleave-on cosmetic products

JACT 5(3):123-65,1986; JACT

13(3):167-230, 1994;IJT 29 (S4): 274-287,


from CIR

Hydroxybenzomorpholine 1 0.03% JACT 10(1):205- 13,1991

Hydroxybutyl Methylcellulose 1 not in use at the time* Amended safetyassessment 03/09 -

Available from CIRhydroxycaproyl phytosphingosine* 1 safe as used Final report 03/2015

available from CIRhydroxycapryloyl phytosphingosine* 1 safe as used Final report 03/2015

available from CIRHydroxycetyl isostearate 1 not in current use* safe as used in cosmetics

when formulatedto be non-irritating


Hydroxyethylcellulose (amended) 1 up to 6% Amended safetyassessment 03/09 -









Hydroxyethyl Cyclodextrin 1 Final report 09/2015available from CIR

Hydroxyethyl Ethylcellulose (amended) 1 up to 3% Amended safetyassessment 03/09 -

Available from CIRHydroxyethylmethacrylate Acetoacetate 1 safe in nail enhancement




IJT 24(S5):53-100,2005

Hydroxylated Lanolin 1 up to 28% JEPT 4(4):63- 92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

hydroxylauroyl phytosphingosine* 1 safe as used Final report 03/2015available from CIR

Hydroxyoctacosanyl Hydroxystearate ` safe as used in cosmeticswhen formulated



hydroxypalmitoyl sphinganine 1 safe as used Final report 03/2015available from CIR

Hydroxypropyl Bis(N-Hydroxyethyl-p-Phenylenediamine)HCl

1 Final report 09/2013available from CIR

Hydroxypropylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -


1986 (original report)Hydroxypropyl Cyclodextrin 1 Final report 09/2015

available from CIRHydroxypropyldimethicone 1 not in current use* IJT 22(S2):11-35,

2003Hydroxypropyl dimethicone/polysorbate 20 crosspolymer 1 not in current use* Final report 09/12

available from CIRHydroxypropyl guar 1 0.05 to 2% in leave-on;

0.1 to 93% in rinse- offIJT 34(S1): 35-65,

2015Hydroxypropyl guar hydroxypropyltrimonium chloride 1 0.04 to 0.9% IJT 34(S1): 35-65,

2015Hydroxypropyl Methacrylate 1 safe in nail enhancement



to avoid skin contact

IJT 24(S5):53-100,2005








Hydroxypropyl Methylcellulose (amended) 1 up to 4% Amended safetyassessment 03/09 -

Available from CIR;JACT 5(3):1-59,

1986 (original report)Hydroxypropyl Methylcellulose Acetate/Succinate 1 not in use at the time* Amended Safety

Assessment 03/09available from CIR

Hydroxypropyl Oxidized Starch 1 Final report 09/2015available from CIR

Hydroxypropyl Starch 1 Final report 09/2015available from CIR

Hydroxypropyltrimonium Hydrolyzed Corn Starch 1 Final report 09/2015available from CIR

Hydroxypropyltrimonium Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR

Hydroxypropyltrimonium Maltodextrin Crosspolymer 1 Final report 09/2015available from CIR

Hydroxypropyl xanthan gum 1 not in current use* Final report 09/12available from CIR

Hydroxystearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Hydroxystearic Acid 1 up to 10% IJT 18(S1):1- 10,1999

Hypericum Perforatum Extract 1 IJT 20(S2):31-39,2001; IJT

33(S3):5-23, 2014Hypericum Perforatum Flower/Leaf/Stem Extract 1 IJT 33(S3):5-23,

2014Hypericum Perforatum Flower/Leaf Extract 1 not in current use* IJT 33(S3):5-23,

2014Hypericum Perforatum Flower/Twig Extract 1 not in current use* IJT 33(S3):5-23,

2014Hypericum Perforatum Flower Extract 1 IJT 33(S3):5-23,

2014Hypericum Perforatum Leaf Extract 1 not in current use* IJT 33(S3):5-23,

2014Hypericum Perforatum Oil 1 IJT 20(S2):31-39,

2001; IJT33(S3):5-23, 2014







Imidazolidinyl Urea 1 up to 1% JEPT 4(4):133- 46,1980 confirmed

09/01 IJT22(S1):1-35, 2003

Inulin 1 Final report 09/2015available from CIR

Iodopropynyl Butylcarbamate (IPBC) 1 safe for use at 0.1%; shouldnot be used in products

intended to be aerosolized

IJT 17(S5):1-37,1998

Irvingia Gabonensis Kernel Butter 1 0.003 to 0.4% Final report 03/11available from CIR

Isoamyl Acetate 1 up to 10% JACT 7(6):705-19,1988

Isoamyl Laurate 1 safe as used in cosmeticswhen formulated



Isobornyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Isobutane 1 up to 85% JACT 1(4):127-42,1982 confirmed

06/02 IJT24(S1):52-55, 2005

Isobutyl Acetate 1 6 to 45% IJT 31(S1):112-136,2012

Isobutyl Benzoate 1 0.01% IJT 31(3):342-372(2012)

Isobutylene/isoprene copolymer* 1 safe as used Final report 06/2015available from CIR

Isobutylene/styrene copolymer 1 Final report 09/2014available from CIR

Isobutyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Isobutyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated


IJT29(S3) :162-186,2010;








Isobutyl Palmitate 1 not in current use* safe as used in cosmeticswhen formulated



Isobutylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4):1-82, 2008

JACT14(5):364-372,1995 (original report)

Isobutyl Pelargonate 1 not in current use* safe as used in cosmeticswhen formulated


Final report 06/10available from CIR;final report 03/2013available from CIR

Isobutyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated




Isobutyl Tallowate 1 not in current use* safe as used in cosmeticswhen formulated



Isoceteth-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012



IJT 31(S2):169-244,2012

Isocetyl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating


Isocetyl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating








Isocetyl Isodecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isocetyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isocetyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isocetyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Isocetyl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating


Isocetyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Isocetyl Stearate 1 up to 30% safe for use in cosmetics whenformulated to be non-irritating



Isodeceth-4 1 safe for use in cosmeticswhen formulated









Isodecyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014

Isodecyl Cocoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isodecyl ethylhexanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isodecyl glyceryl ether 1 not in current use* IJT 32 (S3): 5-21,2013

Isodecyl Hydroxystearate 1 safe for use in cosmetics whenformulated to be non-irritating


Isodecyl isononanoate 1 up to 59% safe for use in cosmetics whenformulated to be non-irritating

IJT 30(S3):228-269,2011; final report








Isodecyl laurate 1 safe for use in cosmetics whenformulated to be non-irritating


Isodecyl Myristate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Isodecyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating


Isodecyl Oleate 1 up to 8% safe for use in cosmetics whenformulated to be non-irritating


11/01 IJT22(S1):1-35, 2003;


Isodecyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isodecyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Isodecyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isododecane 1 safe when formulatedto be non- irritating

IJT 31(S3): 269-295(2012)

Isoeicosane 1 safe when formulatedto be non- irritating

IJT 31(S3): 269-295(2012)

Isohexadecane 1 safe when formulatedto be non- irritating

IJT 31(S3): 269-295(2012)

Isohexyl Caprate 1 safe for use in cosmetics whenformulated to be non-irritating


Isohexyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isohexyl Neopentanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isohexyl Palmitate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isolaureth-10 1 safe when formulatedto be non- irritating

IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)







Isolauryl Behenate 1 safe for use in cosmetics whenformulated to be non-irritating


Isoleucine 1 0.0003 to 0.002% IJT 32(S4):41-64,2013

Isomalt 1 Final report 03/2014available from CIR

Isomerized Jojoba Oil (amended) 1 not in current use* Amended FinalReport 09/08 -

available from CIRIsomyreth-3 1 safe when formulated

to be non- irritatingIJT 31(S2):169-244

(2012)Isomyreth-9 1 safe when formulated

to be non- irritatingIJT 31(S2):169-244

(2012)Isononyl isononanoate 1 up to 64% IJT 30 (S3):228-269,

2011; final report03/2013 available

from CIRIsooctane 1 safe when formulated


(2012)Isooctyl Caprylate/Caprate 1 not in current use* safe for use in cosmetics when


available from CIRIsooctyl Tallate 1 not in current use* safe for use in cosmetics when


available from CIRIsooctyl Thioglycolate 1 safe in hair straighteners,

permanent waves, tonics,dressings, etc., wave sets,other non-coloring hair

products, and hair dyes andcolors at concentrations up to15.2% (as thioglycolic acid);

hairdressers should avoid skincontact and minimize cons

IJT 28(S3):68-133,2009

Isopentane 1 up to 37% JACT 1(4):127-42,1982 confirmed

06/02 IJT24(S1):52-55, 2005

Isopolyglyceryl-3 dimethiconol 1 not in current use* Final report 12/10available from CIR

Isoprene/pentadiene copolymer* 1 safe as used Final report 06/2015available from CIR

Isopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing



12/04 IJT 25(S2),2006

Isopropyl Acetate 1 0.5 to 2% IJT 31(S1):112- 136,2012

Isopropyl Alcohol 1 0.002 to 100% (100% inmanicuring preparations)

IJT 31(S1):112-136,2012







Isopropylamine Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Isopropyl Arachidate 1 safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Avocadate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Babassuate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Benzoate 1 IJT 31(3):342-372(2012)

Isopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014

Isopropyl Cresols 1 up to 5% IJT 25(S1):29-127,2006 (Amended

Report)Isopropyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended Final


1993 (original report)Isopropyl Hydroxystearate 1 safe for use in cosmetics when


available from CIRIsopropylidenediphenyl Bisglycidyl Methacrylate 1 safe in nail enhancement




IJT 24(S5):53-100,2005

Isopropyl Isostearate 1 up to 65% safe for use in cosmetics whenformulated to be non-irritating

JACT 11(1):43-9,1992; final report03/2013 available

from CIRIsopropyl Jojobate 1 safe for use in cosmetics when


available from CIRIsopropyl Lactate 1 Glycolic and Lactic Acid,

their common salts and theirsimple esters, are safe foruse in cosmetic products



IJT 17(S1):1-242,1998








Isopropyl Lanolate 1 up to 26% JEPT 4(4):121- 32,1980 confirmed

06/01 IJT22(S1):1-35, 2003

Isopropyl Laurate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Linoleate 1 safe for use in cosmetics whenformulated to be non-irritating

JACT 11(1):51-56,1992; final report03/2013 available

from CIRIsopropyl Myristate 1 up to 82% safe for use in cosmetics when

formulated to be non-irritatingJACT 1(4):55-80,


24(S1):63-67, 2005;final report 03/2013available from CIR

Isopropyl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Palmitate 1 up to 44% safe for use in cosmetics whenformulated to be non-irritating



Isopropylparaben 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4):1-82, 2008

JACT14(5):364-372,1995 (original report)

Isopropyl Ricinoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

IJT 26(S3) 2007;final report 03/2013available from CIR

Isopropyl Stearate 1 up to 87% safe for use in cosmetics whenformulated to be non-irritating



Isopropyl Tallowate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Isopropyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes


IJT 28(S3):68-133,2009








isopropyl titanium triisostearate/triethoxysilylethylpolydimethylsiloxyethyl dimethicone crosspolymer

1 concentration not reported* Final report 09/12available from CIR

Isostearamide DEA (amended) 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Isostearamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Isostearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Isostearamidopropyl Dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Isostearamidopropyl Morpholine Lactate 1 safe for use in rinse-off products; data are

insufficient to support safetyin leave-on formulations

IJT 18(S3):51-56,1999

Isosteareth-10 1 safe when formulatedto be non- irritating

IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)








IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)


IJT 31(S2):169-244(2012)

Isostearic Acid 1 up to 26% JACT 2(7):61-74,1983 confirmed

09/02 IJT24(S1):55-56, 2005

Isostearyl Acetate 1 0.002 to 5% IJT 31 (S1):112-136,2012

Isostearyl Alcohol 1 up to 50% JACT 7(3):359-413, 1988 confirmed

12/05Isostearyl Avocadate 1 safe for use in cosmetics when


available from CIRIsostearyl Behenate 1 safe for use in cosmetics when


available from CIRIsostearyl Benzoate 1 1% IJT 31(3):342-372

(2012)Isostearyl Erucate 1 not in current use* safe for use in cosmetics when


available from CIRIsostearyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when


available from CIRIsostearyl glucoside 1 safe for use in cosmetics when


2013Isostearyl Glyceryl Ether 1 0.001 to 0.02% IJT 32 (S3): 5-21,

2013Isostearyl Hydroxystearate 1 safe for use in cosmetics when


available from CIRIsostearyl Isononanoate 1 safe for use in cosmetics when


available from CIRIsostearyl Isostearate 1 safe for use in cosmetics when


available from CIRIsostearyl Laurate 1 safe for use in cosmetics when


available from CIRIsostearyl Linoleate 1 safe for use in cosmetics when


available from CIRIsostearyl Myristate 1 not in use at the time* safe for use in cosmetics when


29(S3) :162-186,2010;








Isostearyl Neopentanoate 1 up to 14% safe for use in cosmetics whenformulated to be non-irritating


09/03 IJT 25(S2),2006; final report03/2013 available

from CIRIsostearyl palmitate 1 safe for use in cosmetics when


available from CIRIsostearyl sebacate 1 up to 0.7% IJT 31(S1):5- 76,

2012Isotridecyl isononanoate 1 up to 51% safe for use in cosmetics when



from CIRIsotridecyl Laurate 1 not in current use* safe for use in cosmetics when


available from CIRIsotridecyl Myristate 1 not in current use* safe for use in cosmetics when


29(S3) :162-186,2010;final report 03/2013available from CIR

Isotridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating


Japan (Rhus Succedanea) Wax 1 up to 34% JACT 3 (3):1-41,1984 confirmed

06/03Jojoba Alcohol (amended) 1 up to 1% Amended Final

Report 09/08 -available from CIR

Jojoba Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Jojoba Esters (amended) 1 up to 44% Amended FinalReport 09/08 -

available from CIRJojoba oil PEG-150 esters 1 safe for use in cosmetics when


2014Jojoba oil PEG-8 esters 1 safe for use in cosmetics when


2014Juglans Regia (Walnut) Seed Oil 1 0.00003 to 0.2% Final report 03/11

available from CIRJuniperus Communis Fruit Extract 1 IJT 20(S2):41- 56,

2001Juniperus Oxycedrus Fruit Extract 1 IJT 20(S2):41-56,

2001Juniperus Oxycedrus Tar 1 IJT 20(S2):41-56,

2001







Juniperus Phoenicea Gum Extract 1 IJT 20(S2):41-56,2001

Juniperus Virginiana Wood Extract 1 IJT 20(S2):41 -56,2001

Kaolin 1 up to 100% IJT 22(S1):37-102,2003

Kefiran 1 Final report 03/2014available from CIR

Keratin Amino Acids 1 IJT 33(S4):5-12,2014

Kojic Acid 1 up to 1% IJT 29 (S4): 244-273,2010

Lactamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Lactic Acid 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998

Lactitol 1 Final report 03/2014available from CIR

Lactose 1 Final report 03/2014available from CIR

Lactulose 1 not in current use * Final report 03/2014available from CIR

Laneth-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Laneth-10 Acetate 1 not in current use * JACT 1(4):1-23,1982 confirmed

02/02 IJT24(S1):56-59, 2005



IJT 31(S2):169-244(2012)







Laneth-16 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating


02/02 IJT24(S1):56-59,

2005;IJT31(S2):169-244

(2012)Laneth-20 1 safe for use in cosmetics


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Laneth-5 1 up to 2% safe for use in cosmetics whenformulated to be non-irritating


02/02 IJT24(S1):56-59, 2005;IJT 31(S2):169-244

(2012)Laneth-50 1 safe for use in cosmetics


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Laneth-9 Acetate 1 not in current use * JACT 1 (4):1-23,1982 confirmed

02/02 IJT24(S1):56-59, 2005

Lanolin 1 up to 37% JEPT 4(4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Lanolin Acid 1 up to 10% JEPT 4(4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Lanolin Alcohol 1 up to 4% JEPT 4(4):63 -92,1980 confirmed

02/03 IJT24(S1):2-10, 2005







Lanolinamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Lanolin Oil 1 up to 65% JEPT 4(4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Lanolin Wax 1 up to 25% JEPT 4(4):63-92,1980 confirmed

02/03 IJT24(S1):2-10, 2005

Lapyrium Chloride 1 0.03% in a body wash JACT 10(1):87-97,1991

Lard 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/



IJT 20(S2):57-64,2001

Lard Glyceride 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/



IJT 20(S2):57-64,2001

Lard Glycerides 1 lead 0.1ppm; arsenic 3ppm;mercury 1ppm; total PCB/



IJT 20(S2):57-64,2001

L-Ascorbic Acid 1 up to 10% IJT 24(2):51-111,2005

Lauramide/Myristamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Lauramide DEA (amended) 1 safe in the present practices ofuse and concentration when

formulated to be non-irritatingand when the levels of free

JACT 5(5):415-54,1986 (originalreport); IJT 32

(S1):36-58, 2013







DEA do not exceed thoseconsidered safe int the CIRsafety assessment of DEAand its salts; should not beused in cosmetic products

Lauramide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Lauramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Lauramidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Lauramine 1 JACT 14(3):196-203,1995

Lauramine Oxide 1 safe for use in rinse-off products; but 3.7%for leave-on products


09/09; IJT30(S2):73-127, 2011

Laurdimonium Hydroxypropyl Hydrolyzed Wheat Starch 1 Final report 09/2015available from CIR

Laureth-1 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)









IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)









IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Lauric Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed

06/05 IJT 25(S2),2006

Lauriminodipropionic Acid 1 not in use at the time* Final amended report12/11

Lauroyl arginine 1 safe for use in cosmetics whenformulated to be non-irritating


Lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Lauroyl Ethyltrimonium methosulfate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S3): 296-341(2012)

Lauroyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lauroyl lysine 1 safe for use in cosmeticswhen formulated



Lauroyl proline 1 safe for use in cosmetics whenformulated to be non-irritating


Lauroyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Lauroyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Laurtrimonium bromide 1 safe for use when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Laurtrimonium chloride 1 safe for use when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Lauryl/Myristyl Benzoate 1 not in use at the time* IJT 31(3):342-372(2012)

Lauryl Acrylate/VA Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002







Lauryl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lauryl betaine 1 0.015-8.8% safe for use in cosmetics whenformulated to be non-irritating


Lauryl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lauryl dimethicone/polyglycerin-3 crosspolymer 1 2% Final report 09/12available from CIR

Lauryl dimethicone PEG-15 crosspolymer 1 not in current use* Final report 09/12available from CIR

Lauryl ethylhexanoate 1 safe for use in cosmetics whenformulated to be non-irritating


Lauryl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Lauryl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Lauryl Isopentyl-PEG/PPG-18/18 Methicone* 1 Final report 12/2014available from CIR

Lauryl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lauryl Lactate 1 IJT 17(S1):1-242,1998

Lauryl Laurate 1 safe for use in cosmeticswhen formulated



Lauryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Lauryl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Lauryl Methacrylate/Sodium Methacrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Lauryl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Lauryl Oleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lauryl Palmitate 1 safe for use in cosmetics whenformulated to be non-irritating








Lauryl PEG/PPG-18/18 Methicone 1 Final report 12/2014available from CIR

Lauryl PEG-10 Methyl Ether Dimethicone* 1 Final report 12/2014available from CIR

Lauryl PEG-10 Tris(trimethylsiloxy)silylethyl Dimethicone* 1 Final report 12/2014available from CIR

Lauryl PEG-8 Dimethicone 1 Final report 12/2014available from CIR

Lauryl PEG-8 PPG-8 Dimethicone* 1 Final report 12/2014available from CIR

Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014available from CIR

Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating


Lauryl polydimethylsiloxyethyl dimethicone/bis-vinyldimethicone crosspolymer

1 not in current use* Final report 09/12available from CIR

Lauryl Polyglyceryl-3 PolydimethylsiloxyethylDimethicone*


Lauryl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Lecithin 1 safe as used. IJT 20(S1):21-45,2001; Final report03/2015 available

from CIRLecithinamide DEA 1 safe in the present practices of

use and concentration whenformulated to be non-irritating



IJT 32(S1):36-58,2013

Leucine 1 0.0009 to 0.001% IJT 32(S4):41-64,2013

Levan 1 not in current use* Final report 09/12available from CIR

Lignoceryl Erucate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Limnanthes Alba (Meadowfoam) Seed Oil 1 0.002 to 74% Final report 03/11available from CIR

Linoleamide DEA (amended) 1 safe in the present practices ofuse and concentration when




(S1):36-58, 2013








Linoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Linoleamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Linseed Acid 1 concentration not reported* Final report 03/11available from CIR

Linseed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Linum Usitatissimum (Linseed) Oil 1 0.001 to 10% Final report 03/11available from CIR

Lithium Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003

Lithium Magnesium Sodium Silicate 1 not in current use* IJT 22(S1):37-102,2003

Lithium Stearate 1 up to 3% JACT 1(2):143-177,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Locust bean hydroxypropyltrimonium chloride 1 0.4% in rinse- off IJT 34(S1): 35-65,2015

Luffa Cylindrica Seed Oil 1 up to 0.01% Final report 03/11available from CIR

Lupine amino acids 1 IJT 33(S4):5-12,2014

Lupinus Albus Oil Unsaponifiables 1 not in use at the time* Final report 03/11available from CIR

Lupinus Albus Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Lycium Barbarum Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Lycium Barbarum Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Lysine 1 1.0 x 10-7 to 0.7% IJT 32(S4):41-64,2013

Lysine HCl 1 0.00003 to 0.6% IJT 32(S4):41-64,2013







Lysolecithin 1 safe as used Final report 03/2015available from CIR

Lysophosphatidic Acid 1 safe as used Final report 03/2015available from CIR

Lysophosphatidylethanolamine* 1 safe as used Final report 03/2015available from CIR

Lysophosphatidylglycerol* 1 safe as used Final report 03/2015available from CIR

Macadamia Integrifolia Seed Oil 1 0.00006 to 5% Final report 03/11available from CIR

Macadamia Ternifolia Seed Oil 1 0.0003 to 30% Final report 03/11available from CIR

Macadamia ternifolia seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Magnesium/TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating.

These ingredients shouldnot be used in cosmetic

products in which N-nitrosocompounds can be formed.

IJT 32(S1):59-83,2013

Magnesium Acetate 1 0.02 to 0.03% IJT 31 (S1):112-136,2012

Magnesium Alginate 1 Final report 09/2015available from CIR

Magnesium Aluminum Silicate 1 up to 5% IJT 22 (S1):37-102,2003

Magnesium Ascorbate 1 not in current use* IJT 24(2):51-111,2005

Magnesium Ascorbyl Phosphate 1 up to 3% IJT 24(2):51-111,2005

Magnesium Aspartate 1 0.00005 to 0.1% IJT 32(S4):41-64,2013

Magnesium Benzoate 1 not in use at the time* Final amended report10/11 available from

CIRMagnesium citrate 1 0.01 to 2% IJT 33 (S2): 16 -46,

2014Magnesium Coceth Sulfate 1 safe in the present practices of


IJT29(S3) :151-161,2010

Magnesium Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SMagnesium Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,

2010Magnesium Glycinate 1 not in current use* IJT 32(S4):41-64,

2013Magnesium Hydroxide 1 safe in hair straighteners and

depilatories under conditionsFinal report 12/2015

available from CIR







of recommended use: usersshould minimize skin contact;

all other uses safe whenformulated to be non-irritating

Magnesium Isododecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Magnesium laureth-3 sulfosuccinate 1 safe in the present practices ofuse and concentration when



Magnesium Laureth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Magnesium Methyl Cocoyl Taurate* 1 when formulatedto be non-irritating


Magnesium Myristate 1 up to 10% IJT 29(S3):162-186,2010

Magnesium Oleth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Magnesium palmitoyl glutamate 1 not in current use* safe for use in cosmeticswhen formulated



Magnesium PCA 1 safe as used; shouldnot be used in cosmetic



Magnesium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Magnesium Silicate 1 not in current use* IJT 22(S1):37-102,2003

Magnesium Stearate 1 up to 8% JACT 1(2):143-177, 1982

confirmed 11/01 IJT22(S1):1-35, 2003

Magnesium Sulfate 1 Final report 06/2014available from CIR

Magnesium Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes


IJT 28(S3):68-133,2009








Magnesium Trisilicate 1 not in current use* IJT 22(S1):37-102,2003

Magnisium Myreth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Maleic Acid 1 up to 0.004% as a pH adjuster safe for use as a pH adjuster;fragrance use not addressed

IJT 26(S2):125-130,2007

Malic Acid 1 safe for use as pH adjusters;insufficient data to support

safety for other uses

IJT 20(S1):47-55,2001

Malonic Acid 1 not in current use* IJT 31 (S1):5-76,2012

Maltitol 1 up to 15% Final report 09/08available from CIR

Maltitol Laurate 1 not in current use* Final report 09/08available from CIR

Maltodextrin 1 Final report 09/2015available from CIR

Maltose 1 Final report 03/2014available from CIR

Malus Domestica (Apple) Callus Extract* 1 Final report 03/2016available from CIR

Malus Domestica (Apple) Fiber 1 when formulated to be non-irritating and non-sensitizing


Malus Domestica (Apple) Fruit Cell Culture Extract 1 when formulated to be non-irritating and non-sensitizing


Malus Domestica (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing


Malus Domestica (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing


Malus Domestica (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing


Malus Domestica (Apple) Oil 1 Final report 03/2016available from CIR

Malus Domestica (Apple) Stem Extract 1 Final report 03/2016available from CIR

m-Aminophenol 1 up to 5% JACT 7(3):279-333,1988 confirmed

09/05Manganese citrate 1 not in current use* IJT 33 (S2): 16-46,

2014Manganese tripeptide-1 1 not in current use* Final report 06/2014

available from CIR







Mangifera Indica (Mango) Seed Butter 1 0.0005 to 3% Final report 03/11available from CIR

Mangifera Indica (Mango) Seed Oil 1 0.003 to 6% Final report 03/11available from CIR

Mango Seed Oil PEG-70 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Mannan 1 Final report 09/2015available from CIR

Mannose 1 Final report 03/2014available from CIR

m-Cresol and o-Cresol 1 up to 0.5% IJT 25 (S1):29-127,2006 (Amended

Report)MEA-benzoate 1 safe in the present practices



Final amended report03/12 available from

CIR

MEA-cocoate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

Meadowfoamamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

MEA-laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

MEA-laureth sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should

not be used in cosmetic


CIR







products in which N-nitrosocompounds may be formed

MEA-lauryl sulfate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

MEA-PPG-8 steareth-7 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

MEA-PPG laureth-6 carboxylate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

MEA-Salicylate (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should

not be used in cosmeticproducts in which N-nitrosocompounds may be formed;

when used as a salicylateingredient, safe when

Final amended report03/12 available fromCIR; IJT 22(3):1-108

(original salicylatereport)

MEA-sulfite 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

MEA-tallowate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


CIR








MEA-undecylenate 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should



CIR

Melamine/Formaldehyde Resin (now calledPolyoxymethylene Melamine)

0 JACT 14(5):373-85,1995

Melibiose 1 Final report 03/2014available from CIR

Mentha Piperita (Peppermint) Leaf 1 safe as used, except that theconcentration of pulegone

should not exceed 1%

IJT 20(S3):61-73,2001

Mentha Piperita (Peppermint) Leaf Extract 1 safe as used, except that theconcentration of pulegone


IJT 20(S3):61-73,2001

Mentha Piperita (Peppermint) Leaf Water 1 safe as used, except that theconcentration of pulegone


IJT 20(S3):61-73,2001

Mentha Piperita (Peppermint) Oil 1 safe as used, except that theconcentration of pulegone


IJT 20(S3):61-73,2001

Methacrylic Acid 1 safe as a nail primer in thepresent practices of use bytrained professionals, but

insufficient data to supportretail use by consumers

IJT 24(S5):33-51,2005

Methacrylic Acid/PEG-6 Methacrylate/PEG-6Dimethacrylate Crosspolymer



Methacrylic Acid\ Styrene\ VP Copolymer 1 Final report 09/2014available from CIR

Methacryloyl Ethyl Betaine/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Methenamine 1 0.16%; but should notbe used in products

intended to be aerosolized

JACT 11(4):531-58,1992

Methicone 1 up to 5% IJT 22(S2):11-35,2003

Methionine 1 0.0001 to 0.07% IJT 32(S4):41-64,2013

Methoxydiglycol Methacrylate 1 safe in nail enhancementproducts when skin contact is

IJT 24(S5):53-100,2005







avoided; products containingthis ingredient should be

accompanied with directionsto avoid skin contact


Methoxyisopropanol 1 up to 35%in nail careproducts; fragranceuse not addressed

IJT 27(S2): 25-29,2008

Methoxyisopropyl Acetate 1 not in current use* IJT 27(S2): 25-29,2008

Methoxy PEG/PPG-25/4 Dimethicone 1 Final report 12/2014available from CIR

Methoxy PEG-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Methoxy PEG-100 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)

Methoxy PEG-11 Methoxy PPG-24 Dimethicone* 1 Final report 12/2014available from CIR

Methoxy PEG-13 Ethyl Polysilsesquioxane* 1 Final report 12/2014available from CIR



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Methyl Acetate 1 10 to 60% IJT 31(S1):112-136,2012

Methyl Alcohol 1 safe for use as a denaturant IJT 20(S1):57-85,2001

Methylbenzethonium Chloride 1 0.5% skin; 0.02% eye JACT 4(5):65-106,1985 confirmed

03/04 IJT 25(S2),2006

Methyl Benzoate 1 0.0005 to 0.3% IJT 31(3):342 -372(2012)

Methylcellulose (amended) 1 up to 20% Amended safetyassessment 03/09 -

Available from CIR







JACT 5(3)1-59, 1986(original report)

Methylchloroisothiazolinone (with Methylisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm

JACT 11(1):75-128,1992

Methyl Cocoate (amended) 1 up to 0.06% IJT 30 (S1):5S-16SMethyl Cyclodextrin 1 Final report 09/2015

available from CIRMethyldibromo Glutaronitrile 1 leave-on 0.025% JACT 15(2):140-65,

1996Methylene Chloride 1 brief, discontinuous use only 7 JACT 7(6):741-835,

19887Methylene Glycol 1 1 safe for use in cosmetics

when formulated toensure use at the minimaleffective concentration,but in no case should theformalin concentration

exceed 0.2% (w/w), whichwould be 0.074% (w/w)

calculated as formaldehyde or0.118% (w/w) calculated as

IJT 32(S4):5-32,2013

Methyl Ethylcellulose 1 not in use at the time* Amended SafetyAsessment 03/09

available from CIRMethyl Gluceth-10 1 Final report 09/2013

available from CIRMethyl Gluceth-20 1 Final report 09/2013

available from CIRMethyl glucose caprylate/caprate 1 Final report 09/2013

available from CIRMethyl glucose dioleate 1 Final report 09/2013

available from CIRMethyl glucose isostearate 1 Final report 09/2013

available from CIRMethyl glucose laurate 1 Final report 09/2013

available from CIRMethyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013

available from CIRMethyl glucose sesquicocoate 1 Final report 09/2013

available from CIRMethyl glucose sesquiisostearate 1 Final report 09/2013

available from CIRMethyl glucose sesquilaurate 1 Final report 09/2013

available from CIRMethyl glucose sesquioleate 1 Final report 09/2013

available from CIRMethyl glucose sesquistearate 1 Final report 09/2013

available from CIR







Methyl Glycolate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998

Methyl Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007

Methyl Hydroxyethylcellulose 1 not in use at the time* Amended SafetyAssesment 03/09

available from CIRMethyl Isobutyl Ketone (aka MIBK) 1 safe as used in nail polish

removers and up to 4%as an alcohol denaturant

IJT 23(S1):29-57,2003

Methylisothiazolinone (alone) 1 safe at concentrations upto 100 ppm and safe foruse in leave-on cosmetic

products when formulatedto be non-sensitizingm

which may be determinedbased on a quantitativerisk assessment (QRA).

IJT 29 (S3): 187-213,2010; Final report09/2014 available

from CIR

Methylisothiazolinone (with Methylchloroisothiazolinone) 1 rinse-off 15 ppm;leave-on 7.5 ppm

JACT 11(1):75-128,1992

Methyl Lactate 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998

Methyl Methacrylate/Glycol Dimethacrylate Crosspolymer 1 up to 3% IJT 30 (1): 54-65,2011

Methyl Methacrylate Crosspolymer 1 up to 14% IJT 30 (1): 54-65,2011

Methyl Myristate 1 not in use at the time* IJT29(S3) :162-186,2010

Methylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4): 1-82,2008 JACT








Methyl Pelargonate 1 not in current use* Final report 06/10available from CIR

Methyl Ricinoleate 1 not in current use* IJT 26(S3) 2007Methyl Salicylate 1 safe when formulated to



IJT 22(3):1-108

Methylstyrene/Vinyltoluene Copolymer 1 Final report 09/2014available from CIR

Methyl Thioglycolate 1 in hair straighteners,permanent waves, tonics,dressings, etc., wave sets,other non-coloring hairproducts, and hair dyes



IJT 28(S3):68-133,2009

MIBK (aka Methyl Isobutyl Ketone) 1 safe as used in nail polishremovers and up to 4%as an alcohol denaturant

IJT 23(S1):29-57,2004

Microbial Polysaccharide Gums (see CIR Report with samename)


Microcitrus Australasica Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Microcitrus Australis Fruit Extract 1 safe for use in rinse-off andleave-on cosmetic productswhen formulated to be non-sensitizing and non-irritating,



Microcrystalline Cellulose (amended) 1 up to 57% Amended safetyassessment 03/09 -

Available from CIR







Microcrystalline Wax 1 up to 50% JACT 3(3):43- 99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Milkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Milk amino acids 1 IJT 33(S4):5-12,2014

Minkamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Minkamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Minkamidopropyl dimethylamine 1 safe in cosmetics as longas they are formulatedto be non-sensitizing,



Mink Oil (Amended) 1 up to 3% IJT 24(S3):57-64,2005 IJT

17(S4):71-82, 1998(Original Report)

mink oil PEG-13 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

MIPA-Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Mixed Cresols (amended) 1 IJT 25(S1):29-127,2006

Mixed Isopropanolamines 1 safe for use in cosmeticproducts; but should not beused in products containing



12/04 IJT 25(S2),2006

Monoethanolamine (now Ethanolamine) 1 safe for use in rinse-offproducts; but should not beused in leave-on products

JACT 2(7):183-235,1983







Monosodium citrate 1 0.004 to 5% IJT 33 (S2): 16-46,2014

Montan Wax 1 up to 11% JACT 3(3):43-99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Montmorillonite 1 not in current use* IJT 22 (S1):37-102,2003

Morinda Citrifolia Seed Oil 1 not in current use* Final report 03/11available from CIR

Moringa Oleifera Seed Oil 1 up to 0.001% Final report 03/11available from CIR

Moringa Pterygosperma Seed Oil 1 0.003 to 3% Final report 12/10available from CIR

Morpholine 1 JACT 8(4):707-748,1989

m-Phenylenediamine 1 10% in hair dyes IJT 16(S1):59-116,1997

m-Phenylenediamine Sulfate 1 10% in hair dyes IJT16(S1):59-116,1997

Myreth-10 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Myristamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Myristamide MEA (amended) 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to be

IJT 34(S1): 18-34,2015







non-irritating; shouldnot be used in cosmetic


Myristamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Myristamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Myristic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed

06/05 IJT 25(S2),2006; IJT 29 (S3):

162-186, 2010Myristoyl ethyltrimonium methosulfate 1 Safe in the present practices of

use and concentration, whenformulated to be non-irritating

IJT 31(S3): 296-341(2012)

Myristoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Myristoyl hexapeptide-12 1 not in current use* Final report 06/2014available from CIR

Myristoyl pullulan 1 not in current use* Final report 09/12available from CIR

Myristoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Myristoyl tripeptide-1 1 not in current use* Final report 06/2014available from CIR

Myristyl Acetate 1 not in use at the time* IJT 31(S1):112-136,2012

Myristyl Alcohol 1 up to 5% JACT 7(3):359-413,1988 confirmed

12/05Myristyl Betaine 1 up to 0.84% safe for use in cosmetics when


available from CIRMyristyl Ethylhexanoate 1 not in current use* safe for use in cosmetics when


available from CIR







Myristyl Glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Myristyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Myristyl Isostearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Myristyl Lactate (Amended) 1 safe for use in cosmeticproducts at concentrationsless than or equal to10%,at final formulation pH




IJT 17(S1):1-242,1998 JACT


Myristyl Laurate 1 safe for use in cosmetics whenformulated to be non-irritating


Myristyl Myristate 1 up to 17% safe for use in cosmetics whenformulated to be non-irritating



Myristyl Neopentanoate 1 safe for use in cosmetics whenformulated to be non-irritating


Myristyl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Myristyl Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Myristyl Stearate 1 up to 4% safe for use in cosmetics whenformulated to be non-irritating



Myrtrimonium bromide 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

N,N-Bis(2-Hydroxyethyl)-p- Phenylenediamine Sulfate 1 up to 5% JACT 11(1):129-43,1992

n-Butane (aka Butane) 1 up to 92% JACT 1 (4):127-42,1982 confirmed







06/02 IJT24(S1):52-55, 2005

n-Butyl Alcohol 1 up to 15% in nail products, upto 0.002% in other products

IJT 27(S2): 53-69,2008 JACT


Neopentyl Glycol Dicaprylate/Dipelargonate/Dicaprate 1 not in use at the time* Final report 06/10available from CIR

Neopentyl glycol diisononanoate 1 1% IJT 30 (S3):228-269,2011

Niacin 1 Niacin less than or equalto 0.1%; Niacinamide

less than or equal to3%

IJT 24(S5):1-31,2005

Niacinamide 1 Niacin less than or equalto 0.1%; Niacinamide

less than or equal to3%

IJT 24(S5):1-31,2005

Nitrocellulose 1 Final report 06/13available from CIR

Noneth-8 1 safe as used in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Nonoxynol-1 1 when formulatedto be non-irritating


from CIRNonoxynol-10 1 when formulated

to be non-irritatingJACT 2(7):35-60,1983; Final report12/2015 available


to be non-irritatingFinal report 12/2015

available from CIRNonoxynol-11 1 when formulated











to be non-irritatingJACT 2(7):35-60,1983; Final report











IJT 18(S1):11-31,1999 JACT

2(7):35-60, 1983(Original Report);















to be non-irritatingIJT 18(S1):11-31,

1999 JACT2(7):35-60, 1983

(Original Report);Final report 12/2015


to be non-irritatingJACT 2 (7):35-60,1983; Final report12/2015 available




to be non-irritatingIJT 18(S1):11-31,1999; Final report12/2015 available




to be non-irritatingIJT 18(S1):11-31,1999; Final report














1999 JACT2(7):35-60, 1983

(Original Report);Final report 12/2015



from CIRNonyl Acetate 1 0.0004% IJT 31(S1):112-136,

2012N-Phenyl-p-Phenylenediamine 1 up to 1.7% as the free base JACT 13(5):374-94,

1994N-Phenyl-p-Phenylenediamine HCl 1 up to 1.7% as the free base JACT 13(5):374-94,

1994N-Phenyl-p-Phenylenediamine Sulfate 1 up to 1.7% as the free base JACT 13(5):374-94,

1994Nylon-10/10 1 not in current use* IJT 33(S4):47-60,

2014Nylon-11 1 IJT 33(S4):47-60,

2014Nylon-12 1 IJT 33(S4):47-60,

2014Nylon-12/6/66 1 not in current use* IJT 33(S4):47-60,

2014Nylon-6 1 IJT 33(S4):47-60,

2014Nylon 6/12 1 IJT 33(S4):47-60,

2014Nylon-611 1 not in current use* IJT 33(S4):47-60,

2014Nylon-66 1 IJT 33(S4):47-60,

2014o-aminophenol 1 up to 1% JACT 7(3):279-333,

1988 confirmed09/05

Oatamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)

IJT 34(S1): 18-34,2015







when formulated to benon-irritating; should


Oatamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Oatamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which


Final report 06/2014

Oat amino acids 1 IJT 33(S4):5-12,2014

Octacosanyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,2012

Octacotrimonium chloride 1 Safe as used in cosmeticswhen formulated


IJT 31(S3): 296-341(2012)

Octadecyl D-glucoside 1 Safe as used in cosmeticswhen formulated


IJT 32 (S3): 22-48,2013

Octododecyl Avocadoate 1 not in current use* Safe as used in cosmeticswhen formulated



Octododecyl Beeswax 1 not in current use* Safe as used in cosmeticswhen formulated



Octododecyl Behenate 1 not in current use* Safe as used in cosmeticswhen formulated



Octododecyl Benzoate 1 3 to 4% IJT 31(3):342- 372(2012)

Octododecyltrimonium chloride 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Octoxynol-1 1 up to 30% in permanentwaves, lower for other uses

safe as used in rinse-off products; safe at 5%

in leave-on products

IJT 23(S1):59-111,2004

Octoxynol-10 1 up to 25% in hair bleaches IJT 23(S1):59-111,2004

Octoxynol-11 1 up to 1% IJT 23(S1):59-111,2004

Octoxynol-12 1 not in current use* IJT 23 (S1):59-111,2004










Octoxynol-20 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004


Octoxynol-3 1 not reported* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004



Octoxynol-40 1 up to 0.02% IJT 23(S1):59-111,2004

Octoxynol-5 1 not reported* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004

Octoxynol-6, -7, and -8 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004

Octoxynol-7 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004


Octoxynol-8 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004


Octoxynol-9 Carboxylic Acid 1 not in current use* IJT 23(S1):59-111,2004

Octyldecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldecyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecanol 1 up to 85% JACT 4(5):1-29,1985 confirmed

03/04; IJT 25(S2),2006







Octyldodeceth-10 1 Safe as used in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Octyldodecyl Cocoate (amended) 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Erucate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Ethylhexanoate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Glucoside 1 Safe as used in cosmeticswhen formulated


IJT 32 (S3): 22-48,2013

Octyldodecyl Hydroxystearate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Isostearate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Meadowfoamate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Myristate 1 up to 21% Safe as used in cosmeticswhen formulated


IJT29(S3) :162-186,2010;








Octyldodecyl Neodecanoate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Neopentanoate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Octyldodecanoate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Oleate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Olivate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Ricinoleate 1 up to 5% Safe as used in cosmeticswhen formulated


IJT 26(S3) 2007;final report 03/2013available from CIR

Octyldodecyl Safflowerate 1 not in current use* Safe as used in cosmeticswhen formulated



Octyldodecyl Stearate 1 Safe as used in cosmeticswhen formulated



Octyldodecyl Stearoyl Stearate (amended) 1 up to 15% IJT 24(S3):65-74,2005 IJT

20(S3):51-59, 2001(Original report)

o-Cymen-5-ol (Amended) 1 up to 0.5% IJT 25 (S1):29-127,2006 JACT


Oenothera Biennis (Evening Primrose) Oil 1 0.00002 to 58% Final report 03/11available from CIR

Olea Europaea (Olive) Fruit Oil 1 0.0005 to 100% Final report 03/11available from CIR

Olea Europaea (Olive) Husk Oil 1 not in current use* Final report 03/11available from CIR

Olea Europaea (Olive) Oil Unsaponifiables 1 0.0001 to 3% Final report 03/11available from CIR

Oleamide DEA (amended) 1 safe in the present practices ofuse and concentration when




(S1):36-58, 2013








Oleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Oleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Oleamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which



Oleic Acid 1 up to 50% JACT 6(3):321-401,1987 confirmed

06/05 IJT 25(S2),2006

Oleoyl Sarcosine 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Oleoyl Tyrosine 1 Safe as used in cosmeticswhen formulated



Oleth-10 1 safe as used in cosmeticswhen formulated


IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)









IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)









IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)



IJT 18(S2):17-24,1999; IJT

31(S2):169-244(2012)

Oleyl Alcohol 1 up to 62% JACT 4(5):1-29,1985 confirmed

03/04 IJT 25(S2),2006







Oleyl Arachidate 1 not in current use* safe as used in cosmeticswhen formulated



Oleyl Betaine 1 up to 23.7% safe as used in cosmeticswhen formulated



Oleyl Erucate 1 safe as used in cosmeticswhen formulated



Oleyl Ethyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated



Oleyl Glyceryl Ether 1 not in current use* IJT 32 (S3): 5-21,2013

Oleyl Linoleate 1 safe as used in cosmeticswhen formulated



Oleyl Myristate 1 not in current use* safe as used in cosmeticswhen formulated


IJT29(S3) :162-186,2010;


Oleyl Oleate 1 safe as used in cosmeticswhen formulated



Oleyl Phosphate 1 not in current use* Safe as used in cosmeticswhen formulated



Oleyl Stearate 1 not in current use* safe as used in cosmeticswhen formulated



Olivamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Olivamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015







Olivamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Olivamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Olive Acid 1 not in use at the time* Final report 03/11available from CIR

Olive Oil PEG-10 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Olive oil PEG-6 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014

Olive Oil Propylene Glycol Esters* 1 safe when formulatedto be non- irritating


Orbignya Cohune Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Orbignya Oleifera Seed Oil 1 0.0009 to 27% Final report 03/11available from CIR

orbignya oleifera seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Orbignya Speciosa Kernel Oil 1 0.5 to 0.9% Final report 03/11available from CIR

Oryza Sativa (Rice) Bran 1 concentraton not reported* IJT 25(S2):91-120,2006

Oryza Sativa (Rice) Bran Acid 1 not in current use* These rice derivedingredients as used in



IJT 25(S2):91-120,2006

Oryza Sativa (Rice) Bran Extract 1 concentraton not reported* IJT 25(S2):91-120,2006

Oryza Sativa (Rice) Bran Oil 1 0.0003 to 78% These rice derivedingredients as used in



Final amended report03/11 availablefrom CIR; IJT

25(S2):91-120, 2006(original)

Oryza Sativa (Rice) Bran Wax 1 concentraton not reported* IJT 25(S2):91-120,2006

Oryza Sativa (Rice) Extract 1 not in current use* These rice derivedingredients as used in

IJT 25(S2):91-120,2006








residues or heavy metalsOryza Sativa (Rice) Germ Oil 1 0.003 to 3% These rice derived

ingredients as used inproducts should not contain

significant levels of pesticideresidues or heavy metals

Final amended report03/11 availablefrom CIR; IJT

25(S2):91-120, 2006(original)

Oryza Sativa (Rice) Germ Powder 1 concentraton not reported* IJT 25(S2):91-120,2006

Oryza Sativa (Rice) Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Oryza Sativa (Rice) Starch 1 1 to 97% These rice derivedingredients as used in



IJT 25(S2):91-120,2006

Oxidized beta-glucan 1 not in current use* Final report 09/12available from CIR

Oxyquinoline and Oxyquinoline Sulfate (Amended) 1 Safe for use as stabilizers forhydrogen peroxide in rinse-off hair products; insufficient

data for leave-on uses

IJT 25(S1):1-9, 2006JACT 11(4):497-507,1992 (original report)

Ozokerite 1 up to 22% JACT 3(3):43-99,1984 confirmed

06/03Palm (Elaeis Guineensis) Oil 1 up to 2% IJT 19 (S2):7-28,

2000Palm Acid 1 1 to 17% Final report 03/11

available from CIRPalmamide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013

Palmamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015







Palmamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Palmeth-2 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

Palmitamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Palmitamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Palmitamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Palmitamidopropyl dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which



Palmitic Acid 1 up to 25% JACT 6(3):321-401,1987 confirmed

06/05Palmitoyl alanine 1 not in current use* safe for use in cosmetics when


available from CIRPalmitoyl arginine 1 not in current use* safe for use in cosmetics when


available from CIRPalmitoyl carnitine 1 safe when formulated


(2012)Palmitoyl collagen amino acids 1 safe for use in cosmetics









Palmitoyl glutamic acid 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Palmitoyl glycine 1 safe for use in cosmeticswhen formulated



Palmitoyl gold of pleasure amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Palmitoyl hexapeptide-12 1 Final report 06/2014available from CIR

Palmitoyl Inulin 1 Final report 09/2015available from CIR

Palmitoyl isoleucine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


palmitoyl keratin amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


palmitoyl millet amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


palmitoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


palmitoyl pea amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating


palmitoyl quinoa amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


palmitoyl silk amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Palmitoyl tetrapeptide-7 1 not in current use* Final report 06/2014available from CIR

Palm Kernel Acid 1 2 to 12% Final report 03/11available from CIR

Palm kernelamide DEA 1 safe in the present practices ofuse and concentration when




CIR

Palm kernelamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015







Palm kernelamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Palm Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

p-aminophenol 1 up to 1% JACT 7(3):279-333,1988 confirmed

09/05Pamitoyl ethyltrimonium methosulfate 1 safe when formulated

to be non-irritatingIJT 31(S3): 296-341

(2012)Pamitoyl tripeptide-1 1 Final report 06/2014

available from CIRPanax ginseng root 1 concentration not reported* Final report 09/12

available from CIRPanax ginseng root extract*** 1 0.000002 to 0.5% Final report 09/12

available from CIRPanax ginseng root oil 1 not in current use* Final report 09/12

available from CIRPanax ginseng root powder 1 concentration not reported* Final report 09/12

available from CIRPanax ginseng root protoplast 1 not in current use* Final report 09/12

available from CIRPanax ginseng root water 1 not in current use* Final report 09/12

available from CIRPanax japonicus root extract 1 not in current use* Final report 09/12

available from CIRPanax notoginseng root 1 0.0004% Final report 09/12

available from CIRPanax notoginseng root powder 1 not in current use* Final report 09/12

available from CIRPanax quinquefolium root extract 1 0.0005 to 0.002% Final report 09/12

available from CIRPanthenol 1 up to 25% JACT 6(1):139-62,


2006Pantothenamide MEA 1 safe in the present practices



IJT 34(S1): 18-34,2015

Pantothenic Acid 1 not in use at the time* JACT 6(1):139-62,1987 confirmed







12/04 IJT 25(S2),2006

Paraffin 1 0.03 to 99% JACT 3(3):43-99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Passiflora Edulis Seed Oil 1 0.0007 to 3% IJT 31(S2):169-244(2012)

Passiflora edulis seed oils PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PCA 1 safe as used; shouldnot be used in cosmetic



from CIRp-Chloro-m-Cresol (amended) 1 up to 5% IJT 25 (S1):29-127,

2006 IJT16(S3):235-68,1997

(Original Report)p-Cresol (amended) 1 IJT 25(S1):29-127,

2006Peanut (Arachis Hypogaea) Flour 1 IJT 20(S2):65-77,

2001Peanut (Arachis Hypogaea) Oil 1 up to 25% IJT 20(S2):65-77,

2001Peanut Acid and Peanut Glycerides 1 not in current use* Final amended report

03/11 availablefrom CIR; IJT

20(S2):65-77, 2001(original)

Peanutamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Peanut Oil PEG-6 Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Pectin 1 Final report 09/2015available from CIR

PEG/PPG-10/2 Dimethicone* 1 Final report 12/2014available from CIR

PEG/PPG-10/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


PEG/PPG-10/3 Oleyl Ether Dimethicone* 1 Final report 12/2014available from CIR











PEG/PPG-14/4 Dimethicone 1 JACT 1(4):33-54,1982 confirmed

02/03 IJT24(S1):42-44, 2005;Final report 12/2014

available from CIRPEG/PPG-14/7 Dimethyl Ether 1 safe for use in cosmetics when


available from CIRPEG/PPG-15/15 Dimethicone 1 IJT 24(Suppl.

1):1-102, 2005;Final report 12/2014

available from CIRPEG/PPG-15/5 Dimethicone* 1 Final report 12/2014

available from CIRPEG/PPG-16/2 Dimethicone* 1 IJT 24(Suppl.

1):1-102, 2005;Final report 12/2014


available from CIRPEG/PPG-17/18 Dimethicone 1 JACT 1(4):33-54,


24(S1):42-44, 2005;Final report 12/2014

available from CIRPEG/PPG-17/4 Dimethyl Ether 1 safe for use in cosmetics when





24(S1):42-44, 2005;Final report 12/2014



1):1-102, 2005;Final report 12/2014

available from CIR







PEG/PPG-20/15 Dimethicone 1 JACT 1(4):33-54,1982 confirmed



1):1-102, 2005;Final report 12/2014

available from CIRPEG/PPG-20/22 Butyl Ether Dimethicone* 1 Final report 12/2014

available from CIRPEG/PPG-20/22 Methyl Ether Dimethicone* 1 Final report 12/2014


1):1-102, 2005;Final report 12/2014


1):1-102, 2005;Final report 12/2014



24(S1):42-44, 2005;Final report 12/2014


available from CIRPEG/PPG-22/23 Dimethicone 1 JACT 1(4):33 -54,


24(S1):42-44, 2005;Final report 12/2014


1):1-102, 2005;Final report 12/2014

available from CIRPEG/PPG-22/40 Dimethyl Ether 1 not in current use* safe for use in cosmetics when




1):1-102, 2005;Final report 12/2014

available from CIR







PEG/PPG-24/18 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR

PEG/PPG-25/25 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;


PEG/PPG-27/14 Dimethyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


PEG/PPG-27/27 Dimethicone* 1 IJT 24(Suppl.1):1-102, 2005;


PEG/PPG-27/9 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR





PEG/PPG-30/10 Dimethicone 1 Final report 12/2014available from CIR

PEG/PPG-35/40 Dimethyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating




PEG/PPG-4/12 Dimethicone 1 JACT 1 (4):33-54,1982 confirmed


available from CIRPEG/PPG-4/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when


available from CIRPEG/PPG-40/2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics when


available from CIRPEG/PPG-5/2 Methacrylate/Methacrylic Acid Crosspolymer 1 safe in the present practices of






















PEG/PPG-8/14 Dimethicone 1 IJT 24(Suppl.1):1-102, 2005;







PEG-10 1 0.1 to 0.2% Final report 06/10available from CIR

PEG-10/lauryl dimethicone crosspolymer 1 0.5 to 0.7% Final report 09/12available from CIR

PEG-100 1 not in current use* Final report 06/10available from CIR

PEG-100 castor oil 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-100 hydrogenated castor oil 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-100 Lanolin 1 concentration not reported* Final amended report09/12 available from

CIRPEG-100 Stearate 1 up to 6% IJT 24(S1):1-102,

2005PEG-100 Stearate 1 up to 25% JACT 2(7):17-60,


24(S1):74-80, 2005PEG-10 castor oil 1 safe for use in cosmetics when


2014PEG-10 Cocamine* 1 safe as used when formulated


from CIRPEG-10 Dimethicone 1 JACT 1(4):33-54,


24(S1):42-44, 2005;








PEG-10 dimethicone/vinyl dimethicone crosspolymer 1 concentration not reported* Final report 09/12available from CIR

PEG-10 dimethicone crosspolymer 1 0.6 to 2% Final report 09/12available from CIR

PEG-10 dioleate* 1 safe when formulatedto be non-irritating



IJT 33(S4):13-39,2014

PEG-10 hydrogenated castor oil isostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-10 hydrogenated castor oil triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-10 Hydrogenated Lanolin 1 not in current use* Final amended report09/12 available from

CIRPEG-10 hydrogenated tallow amine* 1 safe as used when formulated


available from CIRPEG-10 Lanolin 1 not in current use* Final amended report


PEG-10 Laurate 1 up to 25% IJT 19(S2):29-41,2000

PEG-10 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR

PEG-10 oleamine* 1 safe as used when formulatedto be non-irritating


PEG-10 Olive Glycerides 1 safe when formulatedto be non- irritating


PEG-10 Polydimethylsiloxyethyl Dimethicone/bis-vinylDimethicone Crosspolymer*


PEG-10 Propylene Glycol 1 not in current use* IJT 20(S4):13-26,2001

PEG-10 sorbitan laurate 1 safe as used when formulatedto be non-irritating

IJT 19 (S2):43-89,2000; Final report06/2015 available

from CIRPEG-10 soyamine* 1 safe as used when formulated


available from CIRPEG-10 Soy Sterol 1 up to 2% IJT 23(S2):23-47,

2004PEG-10 stearamine* 1 safe as used when formulated


available from CIRPEG-10 Sunflower Glycerides 1 safe when formulated

to be non- irritatingFinal report 12/2014

available from CIR







PEG-10 Tsubakiate Glycerides* 1 safe when formulatedto be non- irritating


PEG-115M 1 not in current use* Final report 06/10available from CIR

PEG-11 Avocado Glycerides* 1 safe when formulatedto be non- irritating


PEG-11 Babassu Glycerides* 1 safe when formulatedto be non- irritating



IJT 33(S4):13-39,2014

PEG-11 Cocoa Butter Glycerides* 1 safe when formulatedto be non- irritating


PEG-11 Methyl Ether Dimethicone 1 Final report 12/2014available from CIR

PEG-11 tallow amine* 1 safe as used when formulatedto be non-irritating


PEG-12 1 0.04 to 56% Final report 06/10available from CIR

PEG-120 distearate 1 safe when formulatedto be non-irritating


from CIRPEG-120 methyl glucose dioleate 1 Final report 09/2013

available from CIRPEG-120 methyl glucose triisostearate 1 Final report 09/2013

available from CIRPEG-120 methyl glucose trioleate 1 Final report 09/2013

available from CIRPEG-120 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,

2001PEG-12 cocamine* 1 safe as used when formulated


available from CIRPEG-12 diisostearate 1 safe when formulated


available from CIRPEG-12 dilaurate* 1 safe when formulated




24(S1):42-44, 2005;Final report 12/2014

available from CIRPEG-12 dimethicone/bis-isobutyl PPG-20 crosspolymer 1 not in current use* Final report 09/12

available from CIRPEG-12 dimethicone/PPG-20 crosspolymer 1 not in current use* Final report 09/12

available from CIR







PEG-12 dimethicone crosspolymer 1 0.3 to 2% Final report 09/12available from CIR

PEG-12 Dioleate 1 safe when formulatedto be non-irritating


PEG-12 Distearate 1 safe when formulatedto be non-irritating


from CIRPEG-12 Ditallate* 1 safe when formulated


available from CIRPEG-12 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-12 palmitamine* 1 safe as used when formulated


available from CIRPEG-12 Palm Kernel Glycerides* 1 safe when formulated


available from CIRPEG-12 Stearate 1 up to 1% JACT 2(7):17-60,


24(S1):74-80, 2005PEG-135 1 not in current use* Final report 06/10

available from CIRPEG-13 Mink Glycerides* 1 safe when formulated


available from CIRPEG-13 Sunflower Glycerides 1 safe when formulated


available from CIRPEG-14 1 0.1 to 2% Final report 06/10

available from CIRPEG-14 Avocado Glycerides* 1 safe when formulated


available from CIRPEG-14 Dimethicone 1 JACT 1(4):33-54,


24(S1):42-44, 2005;Final report 12/2014


2000PEG-14M 1 0.05 to 0.5% Final report 06/10

available from CIRPEG-15/lauryl dimethicone crosspolymer 1 0.7 to 2% Final report 09/12

available from CIRPEG-15/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer



PEG-150 dibehenate* 1 safe when formulatedto be non-irritating








PEG-150 dilaurate* 1 safe when formulatedto be non-irritating


from CIRPEG-150 dioleate* 1 safe when formulated


available from CIRPEG-150 distearate 1 safe when formulated


from CIRPEG-150 Lanolin 1 not in current use* Final amended report



PEG-150 Pentaerythrityl Tetrastearate 1 Final report 06/2014available from CIR

PEG-150 Stearate 1 up to 6% IJT 24(S1):1-102,2005


IJT 33(S4):13-39,2014

PEG-15 cocamine 1 safe as used when formulatedto be non-irritating



IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014


CIRPEG-15 hydrogenated tallow amine* 1 safe as used when formulated


available from CIRPEG-15 Jojoba Alcohol 1 safe for use in cosmetics when

formulated to be non-irritatingIJT 31(S2):169-244

(2012)PEG-15 oleamine* 1 safe as used when formulated


available from CIRPEG-15 soyamine* 1 safe as used when formulated


available from CIRPEG-15 stearamine* 1 safe as used when formulated


available from CIRPEG-15 tallow amine* 1 safe as used when formulated


available from CIRPEG-16 1 not in current use* Final report 06/10

available from CIRPEG-160M 1 not in current use* Final report 06/10

available from CIR







PEG-160 Sorbitan Triisostearate 1 safe as used when formulatedto be non-irritating


from CIRPEG-16 castor oil 1 safe for use in cosmetics when


2014PEG-16 Cetyl/Oleyl/Stearyl/Lanolin Alcohol Ether 1 safe for use in cosmetics when


(2012)PEG-16 dilaurate* 1 safe when formulated


available from CIRPEG-16 hydrogenated castor oil 1 safe for use in cosmetics when


2014PEG-16 Macadamia Glycerides 1 safe when formulated


available from CIRPEG-16 Soy Sterol 1 up to 0.5% IJT 23(S2):23- 47,

2004PEG-175 diisostearate 1 safe when formulated






24(S1):42-44, 2005;Final report 12/2014



available from CIRPEG-180M 1 0.05 to 0.08% Final report 06/10

available from CIRPEG-18 castor oil dioleate 1 safe for use in cosmetics when


2014PEG-18 Palm Glycerides* 1 safe when formulated


available from CIRPEG-18 sorbitan trioleate 1 safe as used when formulated


from CIRPEG-190 distearate* 1 safe when formulated


available from CIRPEG-192 Apricot Kernel Glycerides 1 safe when formulated



available from CIR









IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014


PEG-20 Almond Glycerides 1 safe when formulatedto be non- irritating



IJT 33(S4):13-39,2014

PEG-20 cocamine* 1 safe as used when formulatedto be non-irritating


from CIRPEG-20 Corn Glycerides* 1 safe when formulated






available from CIRPEG-20 distearate* 1 safe when formulated


from CIRPEG-20 Evening Primrose Glycerides* 1 safe when formulated




2014PEG-20 hydrogenated castor oil isostearate 1 safe for use in cosmetics when


2014PEG-20 hydrogenated castor oil laurate 1 safe for use in cosmetics when


2014PEG-20 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when


2014PEG-20 hydrogenated castor oil triisostearate 1 safe for use in cosmetics when


2014PEG-20 Hydrogenated Lanolin 1 1.0 to 5.0% Final amended report


PEG-20 Hydrogenated Palm Glycerides 1 safe when formulatedto be non- irritating


PEG-20 hydrogenated tallow amine* 1 safe as used when formulatedto be non-irritating








PEG-20 Lanolin 1 not in current use* Final amended report09/12 available from

CIRPEG-20 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-20M 1 0.4 to 3% Final report 06/10

available from CIRPEG-20 methyl glucose distearate 1 Final report 09/2013

available from CIRPEG-20 methyl glucose sesquicaprylate/sesquicaprate 1 Final report 09/2013

available from CIRPEG-20 methyl glucose sesquilaurate 1 Final report 09/2013

available from CIRPEG-20 methyl glucose sesquistearate 1 Final report 09/2013

available from CIRPEG-20 oleamine* 1 safe as used when formulated


available from CIRPEG-20 Sorbitan Beeswax 1 up to 11% safe for use in the present

practices of use, exceptthat cosmetic fornulations

containing PEG-6, -20,and -75 should not be

used on damaged skin10

IJT 20(S4):27-38,2001

PEG-20 sorbitan cocoate 1 safe as used when formulatedto be non-irritating


from CIRPEG-20 sorbitan isostearate 1 safe as used when formulated


from CIRPEG-20 sorbitan oleate* 1 safe as used when formulated


available from CIRPEG-20 Sorbitan Tetraoleate 1 not in use at the time* IJT 19(S2):43-89,

2000PEG-20 sorbitan triisostearate* 1 safe as used when formulated


from CIRPEG-20 Stearate 1 up to 4% JACT 2(7):17-60,


24(S1):74-80, 2005PEG-20 tallow amine* 1 safe as used when formulated


available from CIRPEG-20 Tsubakiate Glycerides* 1 safe when formulated


available from CIR










PEG-23M 1 0.05% Final report 06/10available from CIR

PEG-240 1 4 to 10% Final report 06/10available from CIR

PEG-24 Hydrogenated Lanolin 1 0.2 to 0.3% Final amended report09/12 available from

CIRPEG-24 Lanolin 1 not in current use* Final amended report





IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014

PEG-25 Lanolin 1 not in current use* Final amended report09/12 available from

CIRPEG-25M 1 not in current use* Final report 06/10

available from CIRPEG-25 Moringa Glycerides* 1 safe when formulated




available from CIRPEG-25 Propylene Glycol Stearate 1 1 to 5% IJT 20(S4):13-26,

2001PEG-25 Soy Sterol 1 up to 2% IJT 23(S2):23-47,

2004PEG-25 tallow amine* 1 safe as used when formulated


available from CIRPEG-26 castor oil 1 safe for use in cosmetics when


2014PEG-26 Jojoba Alcohol 1 safe for use in cosmetics when


(2012)PEG-27 Lanolin 1 not in current use* Final amended report



IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014









from CIRPEG-2 diisononanoate 1 safe when formulated



from CIRPEG-2 diisostearate* 1 safe when formulated


available from CIRPEG-2 Dilaurate* 1 safe when formulated






from CIRPEG-2 hydrogenated castor oil 1 safe for use in cosmetics when


2014PEG-2 hydrogenated tallow amine* 1 safe as used when formulated


available from CIRPEG-2 lauramine* 1 safe as used when formulated



2000PEG-2 Laurate SE 1 up to 25% IJT 19(S2):29-41,

2000PEG-2M 1 0.5% Final report 06/10

available from CIRPEG-2 oleamine 1 safe as used when formulated


available from CIRPEG-2 Olive Glycerides* 1 safe when formulated


available from CIRPEG-2 rapseedamine 1 safe as used when formulated


available from CIRPEG-2 sorbitan isostearate* 1 safe as used when formulated


from CIRPEG-2 sorbitan trioleate* 1 safe as used when formulated


available from CIRPEG-2 soyamine 1 safe as used when formulated


available from CIRPEG-2 stearamine* 1 safe as used when formulated


available from CIR







PEG-2 Stearate 1 up to 2% JACT 2(7):17-60,1983 confirmed

11/02 IJT24(S1):74-80, 2005

PEG-2 Sunflower Glycerides* 1 safe when formulatedto be non- irritating


PEG-2 tallow amine 1 safe as used when formulatedto be non-irritating



IJT 16(S3):269-306,1997; IJT

33(S4):13-39, 2014PEG-30 Glyceryl Cocoate 1 safe when formulated

to be non- irritatingIJT 19(S1):51-59,1999; Final report12/2014 available

from CIRPEG-30 Hydrogenated Castor Oil 1 safe for use in cosmetics when


1997; IJT33(S4):13-39, 2014

PEG-30 Hydrogenated Castor Oil Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-30 Hydrogenated Castor Oil Laurate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-30 Hydrogenated Castor Oil PCA Isostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-30 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-30 Hydrogenated Lanolin 1 not in current use* IJT 18(S1):61-68,1999; Final amended




PEG-30 Lanolin 1 0.50% JACT 1(4):91-102,1982; Final amended




PEG-30 sorbitan beeswax 1 safe as used when formulatedto be non-irritating


PEG-30 sorbitan tetraoleate 1 safe as used when formulatedto be non-irritating


from CIRPEG-30 Sorbitol Tetraoleate Laurate (aka SorbethTetraoleate Laurate)

0 concentration not reported* IJT 19(S2):43-89,2000

PEG-30 Soy Sterol 1 not in current use* IJT 23(S2):23-47,2004
















from CIRPEG-32 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-32 Methyl Ether Dimethicone 1 Final report 12/2014

available from CIRPEG-32 Stearate 1 up to 6% IJT 24(S1):1-102,

2005PEG-33 1 not in current use* Final report 06/10



2014PEG-350 1 1% Final report 06/10

available from CIRPEG-35 Almond Glycerides* 1 safe when formulated




2014PEG-35 hydrogenated castor oil 1 safe for use in cosmetics when


2014PEG-35 Lanolin 1 not in current use* Final amended report


PEG-35 Soy Glycerides 1 safe when formulatedto be non- irritating



IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014

PEG-3 cocamine* 1 safe as used when formulatedto be non-irritating


from CIRPEG-3 dicaprylate/caprate* 1 safe when formulated


available from CIR







PEG-3 diisostearate* 1 safe when formulatedto be non-irritating


PEG-3 Dimethicone 1 JACT 1 (4):33-54,1982 confirmed


available from CIRPEG-3 dioleate* 1 safe when formulated


available from CIRPEG-3 dipalmitate* 1 safe when formulated




from CIRPEG-3 Glyceryl Cocoate 1 safe when formulated


available from CIRPEG-3 Methyl Ether 1 safe for use in cosmetics when


(2012)PEG-3 sorbitan oleate 1 safe as used when formulated


from CIRPEG-3 sorbitan stearate 1 safe as used when formulated


from CIRPEG-3 sorbitan tristearate* 1 safe as used when formulated




available from CIRPEG-400 1 1 to 3% Final report 06/10

available from CIRPEG-40 and -50 Sorbitol Hexaoleate (aka Sorbeth-40 and -50Hexaoleate)

0 concentration not reported* IJT 19(S2):43-89,2000


IJT 33(S4):13-39,2014

PEG-40 distearate* 1 safe when formulatedto be non-irritating


PEG-40 Glyceryl Cocoate 1 safe when formulatedto be non- irritating


from CIR







PEG-40 Hydrogenated Castor Oil 1 safe for use in cosmeticswhen formulated tobe none-irritating

IJT 16(S3):269-306,1997; IJT

33(S4):13-39, 2014PEG-40 hydrogenated castor oil isostearate 1 safe for use in cosmetics when




2014PEG-40 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics when




2014PEG-40 Hydrogenated Lanolin 1 not in current use* Final amended report




PEG-40 Jojoba Alcohol 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)

PEG-40 Lanolin 1 0.25% Final amended report09/12 available from

CIRPEG-40 Olive Glycerides* 1 safe when formulated


available from CIRPEG-40 sorbitan diisostearate 1 safe as used when formulated


from CIRPEG-40 sorbitan lanolate 1 safe as used when formulated

to be non-irritatingIJT 19 (S2):43-89,2000; Final report06/2015 available

from CIRPEG-40 sorbitan laurate 1 safe as used when formulated


from CIRPEG-40 sorbitan oleate* 1 safe as used when formulated


available from CIRPEG-40 sorbitan perisostearate* 1 safe as used when formulated


from CIRPEG-40 sorbitan peroleate 1 safe as used when formulated


from CIRPEG-40 sorbitan stearate 1 safe as used when formulated

to be non-irritatingIJT 19(S2):43-89,2000; Final report








PEG-40 sorbitan tetraoleate 1 safe as used when formulatedto be non-irritating


from CIRPEG-40 Soy Sterol 1 not in current use* IJT 23 (S2):23-47,

2004PEG-40 Stearate 1 up to 7% JACT 2(7):17-60,


24(S1):74-80, 2005PEG-42 Babassu Glycerides* 1 safe when formulated


available from CIRPEG-42 Mushroom Glycerides* 1 safe when formulated




2014PEG-44 sorbitan laurate 1 safe as used when formulated


from CIRPEG-45 1 not in current use* Final report 06/10

available from CIRPEG-450 1 1% Final report 06/10




available from CIRPEG-45 Palm Kernel Glycerides 1 safe when formulated


available from CIRPEG-45 Safflower Glycerides* 1 safe when formulated


available from CIRPEG-4 Caprylic/capric Glycerides* 1 safe when formulated




2014PEG-4 cocamine* 1 safe as used when formulated


available from CIRPEG-4 dicocoate* 1 safe when formulated


available from CIRPEG-4 diheptanoate 1 safe when formulated


available from CIRPEG-4 diisostearate* 1 safe when formulated


available from CIR







PEG-4 Dilaurate 1 safe when formulatedto be non-irritating


from CIRPEG-4 Dimethacrylate 1 safe in nail enhancement




IJT 24(S5):53-100,2005

PEG-4 dioleate* 1 safe when formulatedto be non-irritating




from CIRPEG-4 Distearyl Ether 1 safe for use in cosmetics when


(2012)PEG-4 Ditallow Ether 1 safe for use in cosmetics when


(2012)PEG-4 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-4 Methyl Ether 1 safe for use in cosmetics when


(2012)PEG-4 PEG-12 Dimethicone* 1 Final report 12/2014

available from CIRPEG-4-PPG-7 C13/C15 Alcohol 1 not in current use* safe for use in cosmetics when


available from CIRPEG-4 sorbitan stearate* 1 safe as used when formulated


available from CIRPEG-4 sorbitan triisostearate* 1 safe as used when formulated





2014PEG-50 distearate 1 safe when formulated




2014PEG-50 hydrogenated castor oil isostearate 1 safe for use in cosmetics when




2014







PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014



PEG-50 Lanolin 1 concentration not reported* Final amended report09/12 available from

CIRPEG-50 stearamine* 1 safe as used when formulated


available from CIRPEG-50 Stearate 1 up to 9% JACT 2(7):17-60,


24(S1):74-80, 2005PEG-54 castor oil 1 safe for use in cosmetics when




2014PEG-55 1 not in current use* Final report 06/10





2014PEG-55 Lanolin 1 not in current use* Final amended report


PEG-55 Propylene Glycol Oleate 1 up to 10% IJT 20(S4):13-26,2001


IJT 33(S4):13-39,2014


IJT 33(S4):13-39,2014





CIRPEG-5 hydrogenated castor oil isostearate 1 safe for use in cosmetics when




2014PEG-5 Hydrogenated Corn Glycerides* 1 safe when formulated


available from CIR








CIRPEG-5 hydrogenated tallow amine 1 safe as used when formulated


available from CIRPEG-5 Isononanoate 1 1% Final report 06/10

available from CIRPEG-5 Lanolin 1 concentration not reported* Final amended report


PEG-5M 1 0.01% Final report 06/10available from CIR



PEG-5 sorbitan isostearate* 1 safe as used when formulatedto be non-irritating


from CIRPEG-5 soyamine 1 safe as used when formulated


available from CIRPEG-5 Soy Sterol 1 up to 2% IJT 23(S2):23-47,

2004PEG-5 stearamine* 1 safe as used when formulated


available from CIRPEG-5 Tsubakiate Glycerides* 1 safe when formulated




available from CIRPEG-60 Almond Glycerides 1 safe when formulated




2014PEG-60 castor oil isostearate 1 safe for use in cosmetics when


2014PEG-60 castor oil isostearate 1 safe for use in cosmetics when

formulated to be non-irritatingFinal amended report09/12 available from

CIRPEG-60 Corn Glycerides* 1 safe when formulated


available from CIRPEG-60 Evening Primrose Glycerides* 1 safe when formulated






2014







PEG-60 hydrogenated castor oil pca isostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-60 Hydrogenated Castor Oil Triisostearate 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

PEG-60 Lanolin 1 0.4 to 2% Final amended report09/12 available from

CIRPEG-60 Passiflora Edulis Seed Glycerides* 1 safe when formulated


available from CIRPEG-60 Passiflora Incarnata Seed Glycerides* 1 safe when formulated


available from CIRPEG-60 Shea Butter Glycerides 1 safe when formulated


available from CIRPEG-60 sorbitan stearate* 1 safe as used when formulated


from CIRPEG-60 sorbitan tetraoleate 1 safe as used when formulated


from CIRPEG-60 sorbitan tetrastearate* 1 safe as used when formulated


from CIRPEG-60 Sorbitol Tetrastearate (aka Sorbeth Tetrastearate) 0 concentration not reported* IJT 19(S2):43-89,

2000PEG-60 Tsubakiate Glycerides* 1 safe when formulated




2014PEG-65M 1 not in current use* Final report 06/10

available from CIRPEG-6 Almond Glycerides* 1 safe when formulated


available from CIRPEG-6 Caprylic/capric Glycerides 1 safe when formulated






from CIRPEG-6 Dimethicone* 1 Final report 12/2014

available from CIRPEG-6 dioleate* 1 safe when formulated


available from CIR










formulated to be non-irritatingFinal amended report09/12 available from

CIRPEG-6 Hydrogenated Palm/palm Kernel Glyceride* 1 safe when formulated


2014PEG-6 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-6 Methyl Ether 1 safe for use in cosmetics when


(2012)PEG-6 Methyl Ether Dimethicone 1 Final report 12/2014





available from CIRPEG-6 Sorbitan Beeswax 1 not in current use* safe for use in the present




IJT 20 (S4):27-38,2001

PEG-6 sorbitan oleate 1 safe as used when formulatedto be non-irritating


PEG-6 Sorbitan Oleate 1 not in use at the time* IJT 19(S2):43-89,2000

PEG-6 sorbitan stearate 1 safe as used when formulatedto be non-irritating


PEG-6 Sorbitan Stearate 1 not in use at the time* IJT 19(S2):43-89,2000

PEG-6 Stearate 1 up to 6% IJT 24(S1):1-102,2005


PEG-7/PPG-2 Propylheptyl Ether 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating



CIRPEG-70 Lanolin 1 not in current use* Final amended report


PEG-70 Lanolin 1 Final amended report09/12 available from

CIR







PEG-70 Mango Glycerides 1 safe when formulatedto be non- irritating




IJT 33(S4):13-39,2014

PEG-75 Cocoa Butter Glycerides 1 safe when formulatedto be non- irritating


PEG-75 crambe abyssinica seed oil 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014







from CIRPEG-75 Lanolin 1 0.001 to 15% Final amended report


PEG-75 Lanolin 1 Final amended report09/12 available from

CIRPEG-75 Lanolin Oil 1 concentration not reported* Final amended report


PEG-75 Lanolin Wax 1 not in current use* Final amended report09/12 available from

CIRPEG-75 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-75 meadowfoam oil 1 safe for use in cosmetics when


2014PEG-75 Propylene Glycol Stearate 1 not in current use* IJT 20(S4):13-26,

2001PEG-75 Shea Butter Glycerides 1 safe when formulated


available from CIRPEG-75 Shorea Butter Glycerides* 1 safe when formulated


available from CIRPEG-75 sorbitan lanolate* 1 safe as used when formulated


from CIRPEG-75 sorbitan laurate 1 safe as used when formulated

to be non-irritatingIJT 19 (S2):43-89,2000; Final report








PEG-75 Soy Glycerides* 1 safe when formulatedto be non- irritating


PEG-78 Glyceryl Cocoate* 1 safe when formulatedto be non- irritating


from CIRPEG-7 Caprylic/capric Glycerides 1 safe when formulated


available from CIRPEG-7 Cocoglycerides* 1 safe when formulated


available from CIRPEG-7 Dimethicone 1 JACT 1(4):33-54,


24(S1):42-44, 2005;Final report 12/2014

available from CIRPEG-7 Glyceryl Cocoate 1 safe when formulated





available from CIRPEG-7 Methyl Ether 1 safe for use in cosmetics when


(2012)PEG-7 Methyl Ether Dimethicone* 1 Final report 12/2014



available from CIRPEG-7 Propylheptyl Ether 1 safe for use in cosmetics when


(2012)PEG-7 Sunflower Glycerides* 1 safe when formulated


available from CIRPEG-7 tallow amine* 1 safe as used when formulated







2014PEG-80 Glyceryl Cocoate 1 safe when formulated

to be non- irritatingIJT 19(S1):51-59,1999; Final report









IJT 33(S4):13-39,2014

PEG-80 methyl glucose laurate 1 not in current use* Final report 09/2013available from CIR

PEG-80 sorbitan laurate 1 safe as used when formulatedto be non-irritating


from CIRPEG-80 sorbitan palmitate* 1 safe as used when formulated


from CIRPEG-85 Lanolin 1 JACT 1(4):91-102,

1982; Final amendedreport 09/12 available

from CIRPEG-8 Caprylic/capric Glycerides 1 safe when formulated




2014PEG-8 Cetyl Dimethicone 1 Final report 12/2014

available from CIRPEG-8 cocamine* 1 safe as used when formulated


available from CIRPEG-8 dicocoate 1 safe when formulated




available from CIRPEG-8 dilaurate 1 safe when formulated




24(S1):42-44, 2005;Final report 12/2014

available from CIRPEG-8 Dimethicone/dimer Dilinoleic Acid Copolymer 1 Final report 12/2014

available from CIRPEG-8 dimethicone/polysorbate 20 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,

2014PEG-8 Dimethicone Dimer Dilinoleate* 1 Final report 12/2014

available from CIRPEG-8 dioleate 1 safe when formulated


available from CIR









from CIRPEG-8 ditallate* 1 safe when formulated




2014PEG-8 Hydrogenated Fish Glycerides* 1 safe when formulated


available from CIRPEG-8 hydrogenated tallow amine 1 safe as used when formulated



2000PEG-8 Methicone 1 Final report 12/2014

available from CIRPEG-8 Methyl Ether Dimethicone* 1 Final report 12/2014

available from CIRPEG-8 PEG-4 Dimethicone* 1 Final report 12/2014

available from CIRPEG-8 PPG-8 Dimethicone* 1 Final report 12/2014

available from CIRPEG-8 Propylene Glycol Cocoate 1 1 to 5% IJT 20(S4):13-26,

2001PEG-8 Propylheptyl Ether 1 safe for use in cosmetics when


(2012)PEG-8 Sorbitan Beeswax 1 not in current use* safe for use in the present




IJT 20(S4):27-38,2001

PEG-8 soyamine* 1 safe as used when formulatedto be non-irritating


PEG-8 Stearate 1 up to 3% JACT 2(7):17-60,1983 confirmed

11/02 IJT24(S1):74-80, 2005



PEG-90 diisostearate 1 safe when formulatedto be non-irritating


PEG-90M 1 0.0002 to 0.3% Final report 06/10available from CIR


IJT 33(S4):13-39,2014







PEG-9 Cocoglycerides* 1 safe when formulatedto be non- irritating


PEG-9 Dimethicone 1 JACT 1(4):33-54,1982 confirmed




from CIRPEG-9 Laurate 1 up to 25% IJT 19(S2):29-41,

2000PEG-9M 1 not in current use* Final report 06/10

available from CIRPEG-9 Methyl Ether Dimethicone* 1 Final report 12/2014

available from CIRPEG-9 Polydimethylsiloxyethyl Dimethicone 1 Final report 12/2014

available from CIRPEG-Cetyl Stearyl Diether 1 safe for use in cosmetics when


(2012)PEGgreater than or equal to4 0 because PEGs of various

chain lengths are likely tobe added to the International

Cosmetic IngredientDictionary and Handbook

in the future, the CIRExpert Panel concluded

that any PEG greater thanor equal to 4 would be

safe for use in cosmetics


Pelargonic Acid 1 not in use at the time* IJT 30(S3):228-269,2011

Pentaerythrityl Cocoate (amended) 1 concentration not reported* IJT 30(S1):5S-16SPentaerythrityl Rosinate 1 JACT 13(5):395-399,

1994; IJT17(S4):83-94, 1998

Pentaerythrityl Tetrabehenate 1 2 to 3% Final report 12/11available from CIR

Pentaerythrityl Tetrabehenate/Benzoate/Ethylhexanoate 1 0.5 to 16% Final report 12/11available from CIR

Pentaerythrityl Tetrabenzoate 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetra C5-10 Acid Esters 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetra C5-9 Acid Esters 1 not in use at the time* Final report 12/11available from CIR







Pentaerythrityl Tetracaprylate/Tetracaprate 1 0.07 to 5% Final report 12/11available from CIR

Pentaerythrityl Tetracocoate 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetra-Di-t-Butyl Hydroxyhydrocinnamate 1 0.00001- 0.8% Final report 03/2014available from CIR

Pentaerythrityl Tetraethylhexanoate 1 0.06 to 50% Final report 12/11available from CIR

Pentaerythrityl Tetraethylhexanoate/Benzoate 1 40% Final report 12/11available from CIR

Pentaerythrityl Tetraisononanoate 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetraisostearate 1 0.1 to 55% Final report 12/11available from CIR

Pentaerythrityl Tetramyristate 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetraoleate 1 not in use at the time* Final report 12/11available from CIR

Pentaerythrityl Tetrapelargonate 1 2% Final report 12/11available from CIR

Pentaerythrityl Tetrastearate 1 7% Final report 12/11available from CIR

Pentasodium Pentetate 1 up to 3% IJT 27 (S2): 71-92,2008

Pentetic Acid 1 up to 0.03% IJT 27 (S2): 71-92,2008

Pentylene Glycol 1 0.001 to 5% IJT 31 (S2): 147-168,2012

Perfluorononyl dimethicone/methicone/amodimethiconecrosspolymer

1 0.70% IJT 33 (S2): 65-115,2014

Perilla Ocymoides Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Persea Gratissima (Avocado) Butter 1 concentration not reported* Final report 03/11Available from CIR

Persea Gratissima (Avocado) Oil 1 0.0001 to 98% Final amended report03/11 available

from CIR; JEPT4(4):93-103, 1980

(original) re-reviewIJT 22(S1):1-35,

2003Persea Gratissima (Avocado) Oil Unsaponifiables 1 0.2 to 6% Final report 03/11

available from CIRPersea Gratissima (Avocado) Sterols 1 Final report 12/2013

available from CIR







Petroleum Distillates (aka Petroleum Distillate) 1 up to 82% JACT 5(3):225-248,1986 confirmed

12/06Phaseolus Angularis Seed Starch 1 Final report 09/2015

available from CIRPhaseolus Radiatus Seed Starch 1 Final report 09/2015

available from CIRPhenethyl Alcohol 1 up to 1% JACT 9(2):165-83,

1990 confirmed08/06

Phenoxyethanol 1 less than or equalto 0.0002 to 1%

JACT 9(2):259-77,1990

Phenylalanine 1 0.00009 to 0.03% IJT 32(S4):41-64,2013

Phenyl Methyl Pyrazolone 1 up to 1% JACT 11 (4):475-88,1992

Phenyl Trimethicone 1 up to 36% JACT 5(5):353-71, 1986 confirmed

06/04 IJT 25(S2),2006

Phloroglucinol 1 JACT 14(6):468-75,1995

Phosphatidic Acid* 1 safe as used Final report 03/2015available from CIR

Phosphatidylcholine 1 safe as used Final report 03/2015available from CIR

Phosphatidylglycerol* 1 safe as used Final report 03/2015available from CIR

Phosphatidylinositol* 1 safe as used Final report 03/2015available from CIR

Phosphatidylserine* 1 safe as used Final report 03/2015available from CIR

Phospholipids 1 safe as used Final report 03/2015available from CIR

P-hydroxyanisole 1 1 safe for use in nail adhesivesand in artificial nail coatings,as a polymerization inhibitor,that are cured by LED light;

unsafe for use in all othercosmetics due to dermaldepigmentation potential

JACT 4 (5):31-63,1985 confirmed

09/03 IJT 25(S2),2006; Final report12/2014 available

from CIRPhytantriol 1 up to 3% IJT 26(S1):107- 114,

2007Phytosterols 1 Final report 12/2013

available from CIRPhytosteryl butyrate 1 not in current use* Final report 12/2013

available from CIRPhytosteryl canolate 1 Final report 12/2013

available from CIR







Phytosteryl caprylate/caprate 1 not in current use* Final report 12/2013available from CIR

Phytosteryl hydroxystearate 1 not in current use* Final report 12/2013available from CIR

Phytosteryl isostearate 1 Final report 12/2013available from CIR

Phytosteryl linoleate 1 not in current use* Final report 12/2013available from CIR

Phytosteryl linoleate\linoleate 1 not in current use* Final report 12/2013available from CIR

Phytosteryl Macadamiate 1 Final report 12/2013available from CIR

Phytosteryl Nonanoate 1 not in use at the time* IJT 30(S3):228-269,2011; Final report12/2013 available

from CIRPhytosteryl Oleate 1 Final report 12/2013

available from CIRPhytosteryl Rice Branate 1 Final report 12/2013

available from CIRPhytosteryl Ricinoleate 1 not in current use* Final report 12/2013

available from CIRPhytosteryl sunflowerseedate 1 not in current use* Final report 12/2013

available from CIRPicramic Acid 1 up to 0.6% IJT 28(S3): 205-216,

2009Piper Methysticum Leaf/Root/Stem Extract 1 IJT 28(S2): 175-188,

2009Piper Methysticum Root Extract 1 IJT 28(S2): 175-188,

2009Pistacia Vera Seed Oil 1 0.003 to 1% Final report 03/11

available from CIRPisum Sativum (Pea) Starch 1 Final report 09/2015

available from CIRPlacental Enzymes 1 if used, should not deliver



IJT 21(S1):81-91,2002

Placental Lipids 1 if used, should not deliverany metabolic/endocrineactivity, and they must be


IJT 21(S1):81-91,2002

Placental Proteins 1 if used, should not deliverany metabolic/endocrineactivity, and they must be

IJT 21(S1):81-91,2002








Plukenetia Volubilis Seed Oil 1 0.05 to 0.6% Final report 03/11available from CIR

p-Methylaminophenol 1 up to 0.7% Final AmendedReport 12/07


1991 (original report)p-Methylaminophenol Sulfate (amended) 1 up to 0.7% Final Amended


1991 (original report)Polianthes Tuberosa Polysaccharide 1 Final report 09/2015

available from CIRPoloxamer 101 1 not in current use* IJT 27 (S2): 93-128,

2008Poloxamer 105 1 up to 3% IJT 27 (S2): 93-128,

2008Poloxamer 105 Benzoate 1 not in current use* IJT 27 (S2): 93-128,

2008Poloxamer 108 1 not in current use* IJT 27 (S2): 93-128,






2008Poloxamer 182 Benzoate 1 not in current use* IJT 27 (S2): 93-128,






2008







Poloxamer 215 1 not in current use* IJT 27 (S2): 93-128,2008

Poloxamer 217 1 concentration not reported* IJT 27 (S2): 93-128,2008


Poloxamer 234 1 up to 10% IJT 27 (S2): 93-128,2008








Poloxamer 333 1 1% IJT 27 (S2): 93-128,2008

Poloxamer 334 1 0.3% IJT 27 (S2): 93-128,2008






Poloxamer 407 1 up to 20% IJT 27 (S2): 93-128,2008

Polstyrene/hydrogenated polyisopentene copolymer 1 Final report 09/2014available from CIR

Poly(C20-28 olefin)* 1 safe as used Final report 06/2015available from CIR

Poly(C30-45 olefin) 1 safe as used Final report 06/2015available from CIR









Polyacrylamide (Amended) 1 safe if the level of acrylamidemonomer in formulationis not greater than 5ppm

IJT 24(S2):21-50,2005 JACT

10(1):193-203, 1991(Original Report)

Polyacrylate-12 1 not in current use* Final report 09/2014available from CIR

Polyacrylate-15 1 Final report 09/2014available from CIR







Polyacrylic Acid 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Polyamino Sugar Condensate 1 up to 1% JACT 1 (4):25-32,1982 confirmed

02/02 IJT24(S1):80-81, 2005

Polybutene 1 safe as used JACT 1(4):103-18,1982 confirmed


available from CIRPolybutylene terephthalate 1 IJT 33(S3):36-47,

2014Polydecene 1 safe as used Final report 06/2015

available from CIRPolydimethylsiloxyethyl dimethicone/bis-vinyldimethiconecrosspolymer


Polyethylene 1 safe as used IJT 26(S1):115-127,2007; Final report06/2015 available

from CIRPolyethylene isoterephthalate 1 IJT 33(S3):36-47,

2014Polyethylene terephthalate 1 IJT 33(S3):36-47,

2014







Polyglyceryl-20 Octaisononanoate 1 3% Final report 12/11available from CIR

Polyglyceryl-2 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from

CIRPolyglyceryl-3/lauryl polydimethylsiloxyethyl dimethiconecrosspolymer


Polyisobutene 1 safe as used IJT 27(S4): 83-106,2008; Final report06/2015 available

from CIRPolyisoprene 1 safe as used Final report 06/2015

available from CIRPolymethyl Methacrylate (PMMA) 1 up to 30% IJT 30 (1): 54-65,

2011Polyoxymethylene Melamine (formerly Melamine/Formaldehyde Resin)

1 JACT 14(5):373-85,1995

Polyoxymethylene Urea 1 concentration of freeformaldehyde should be0.2%; unsafe for aerosols


12/09Polypentaerythrityl terephthalate 1 not in current use* IJT 33(S3):36-47,

2014Polypentene* 1 safe as used Final report 06/2015

available from CIRPolypropylene 1 safe as used Final report 06/2015

available from CIRPolypropylene Glycols (PPG) 1 50% JACT 13 (6):437-91,

1994 reopened 12/09tentative amended


Polypropylene Terephthalate 1 IJT 33(S3):36-47,2014

Polyquaternium-10 1 up to 5% JACT 7(3): 335-51,1988 confirmed

09/05Polyquaternium-11 1 up to 10% JACT 2(5):161-78,


24(S1):82-83, 2005Polyquaternium-14 1 safe when formulated


(2012)Polyquaternium-22 1 Final report 09/2013

Available from CIRPolyquaternium-28 1 safe when formulated


(2012)Polyquaternium-32 1 safe when formulated


(2012)







Polyquaternium-33 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)

Polyquaternium-39 1 Final report 09/2013Available from CIR


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)


IJT 31(S3): 296-341(2012)

Polyquaternium-7 1 up to 0.4% JACT 14(6):476-84, 1995; confirmed

04/2010Polyquaternium-73 1 safe when formulated


(2012)Polyquaternium-91 1 safe when formulated


(2012)Polysilicone-13 1 Final report 12/2014

available from CIRPolysilicone-2 1 1 The CIR Expert Panel

concluded that polysilicone-2,polysilicone-4, and

polysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.

encapsulating metal oxides) ,and that the available data orinformation are insufficientto make a determination that

these ingredients are safefor their use independently

or for other functions aslisted in the Dictionary

(e.g., antifoaming agents,hair conditioning agents,and viscosity increasingagents - nonaqueous).

Final 03/2016available from CIR







Polysilicone-4 1 1 The CIR Expert Panelconcluded that polysilicone-2,

polysilicone-4, andpolysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.






Polysilicone-5 1 1 The CIR Expert Panelconcluded that polysilicone-2,

polysilicone-4, andpolysilicone-5 are safein cosmetics when usedas surface modifiers (i.e.






Polysorbate 20 1 safe as used when formulatedto be non-irritating

JACT 3(5):1-82,1984; Final report06/2015 available

from CIRPolysorbate 21 1 safe as used when formulated

to be non-irritatingJACT 3(5):1-82,





from CIR







Polysorbate 60 1 safe as used when formulatedto be non-irritating

JACT 3(5):1-82,1984; Final report06/2015 available
















from CIRPolystyrene 1 Final report 09/2014

available from CIRPolyvinyl Acetate (Amended) 1 less than 25% of a

55 to 60% emulsionJACT 15(2):166-76,

1996 JACT11(4):465-73, 1992

(Original Report)Polyvinyl Alcohol 1 up to 10% IJT 17(S5):67-94,

1998Potassium Acetate 1 3% IJT 31(S1):112-136,

2012Potassium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices of



Potassium Alginate 1 Final report 09/2015available from CIR

Potassium Aluminum Polyacrylate 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Potassium Ascorbyl Tocopheryl Phosphate 1 less than or equal to 0.02% IJT 21(S3):51-116,2002; Final report03/2014 available

from CIRPotassium Aspartate 1 0.003 to 0.008% IJT 32(S4):41-64,

2013







Potassium Babassuate 1 not in use at the time* Final report 03/11available from CIR

Potassium Benzoate 1 0.0002 to 0.0003% Final report 10/11available from CIR

Potassium Bromate 1 10.17% (calculatedas Sodium Bromate)

JACT 13(5):400-14,1994

Potassium Butyl Ester of PVM/MA Copolymer (Amended) 1 not in current use* Amended FinalReport 06/09


1993 (original report)Potassium C11-15 alkyl phosphate 1 not in current use* safe for use in cosmetics when


available from CIRPotassium C12-13 alkyl phosphate 1 safe for use in cosmetics when


available from CIRPotassium C12-14 alkyl phosphate 1 not in current use* safe for use in cosmetics when


available from CIRPotassium C9-15 alkyl phosphate 1 safe for use in cosmetics when


available from CIRPotassium Caproyl Tyrosine 1 not in current use* safe for use in cosmetics when


available from CIRPotassium capryloyl glutamate 1 not in current use* safe for use in cosmetics when


available from CIRPotassium Carrageenan 1 Final report 09/2015

available from CIRPotassium Cellulose Succinate 1 not in use at the time* Amended Safety

Assessment 03/09available from CIR

Potassium Cetyl Phosphate 1 safe for use when formulatedto be non- irritating


Potassium Chlorate 1 JACT 14(3):221-30,1995

Potassium citrate 1 0.002 to 0.6% IJT 33 (S2): 16-46,2014

Potassium Cocoate (amended) 1 0.003 to 40% IJT 30(S1):5S-16SPotassium cocoyl glutamate 1 safe for use in cosmetics when


available from CIRPotassium cocoyl glycinate 1 safe for use in cosmetics when


available from CIRPotassium Cocoyl Hydrolyzed Collagen (formerlyPotassium-Coco-Hydrolyzed Animal Protein)

1 up to 20% JACT 2(7):75-86,1983 confirmed

11/02 IJT 24(S1):82-85, 2005

Potassium cocoyl rice amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium Cocoyl Taurate* 1 when formulatedto be non-irritating








Potassium Cornate 1 not in current use* IJT 30 (S1):17-39,2011; Final report


Potassium Cumenesulfonate 1 not in current use* IJT 30(S3):270-283,2011

Potassium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR

Potassium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010

Potassium Ethyl Ester of PVM/MA Copolymer 1 not in current use* IJT 30 (S2):128-144,2011

Potassium Gluconate 1 Final report 03/2014available from CIR

Potassium Glycolate 1 IJT 17(S1):1-242,1998

Potassium Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,2007

Potassium Glycyrrhizinate 1 not in current use* IJT 26(S2):79-112,2007

Potassium Hyaluronate 1 concentration not reported* IJT 28 (1): 5-67,2009

Potassium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SPotassium Hydrogenated Palmate 1 not in current use* Final report 03/11

available from CIRPotassium Hydroxide 1 safe in hair straighteners and

depilatories under conditionsof recommended use: users




Potassium Lactate 1 IJT 17(S1):1-242,1998

Potassium lauroyl collagen amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium lauroyl glutamate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium lauroyl oat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium lauroyl pea amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium lauroyl silk amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Potassium Lauryl Phosphate 1 safe for use in cosmetics whenformulated to be non-irritating








Potassium Metabisisulfite 1 concentration not reported* IJT 22(S2):63-88,2003

Potassium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating


Potassium Myristate 1 up to 7% IJT 29(S3) :162-186,2010

Potassium Myristoyl Glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Potassium Octoxynol-12 Phosphate 1 up to 0.05% IJT 23(S1):59-111,2004

Potassium Olivate 1 concentration not reported* Final report 03/11available from CIR

Potassium olivoyl/lauroyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium Palmate 1 0.3 to 3% Final report 03/11available from CIR

Potassium Palm Kernelate 1 0.3 to 30% Final report 03/11available from CIR

Potassium PCA 1 safe as used; shouldnot be used in cosmetic



Potassium Peanutate 1 not in current use* Final report 03/11available from CIR

potassium PEG-50 hydrogenated castor oil succinate* 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Potassium Persulfate 1 safe as oxidizing agentsin hair colorants and

lighteners designed forbrief, discontinuous usefollowed by thorough


IJT 20(S3):7-21,2001

Potassium Polyacrylate 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Potassium Rapeseedate 1 not in current use* Final report 03/11available from CIR

Potassium Ricinoleate 1 not in current use* IJT 26(S3) 2007Potassium Safflowerate 1 not in current use* Final report 03/11

available from CIRPotassium Salicylate 1 safe when formulated to



IJT 22(3):1-108

Potassium Silicate 1 not reported* safe for use when formulatedto avoid skin irritation

IJT 24(S1):103-117,2005







Potassium Sorbate 1 up to 1% JACT 7(6):837-80,1988 confirmed

04/06Potassium Soyate 1 not in current use* Final report 03/11

available from CIRPotassium Stearate 1 up to 12% JACT 1(2):143-

77, 1982 confirmed11/01 IJT

22(S1):1-35, 2003Potassium Stearoyl glutamate 1 not in current use* safe for use in cosmetics when


available from CIRPotassium Sulfite 1 concentration not reported* IJT 22(S2):63-88,

2003Potassium Tallate 1 concentration not reported* IJT 28(S3):252-258,

2009Potassium Taurate* 1 when formulated

to be non-irritatingFinal Report 12/2015

available from CIRPotassium Thioglycolate 1 safe for use in hair

straighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair



IJT 28(S3):68-133,2009

Potassium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011

Potassium Undecylenoyl Alginate 1 Final report 09/2015available from CIR

Potassium Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR

Potassium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011

Potassium Xylenesulfonate 1 not in current use* IJT 30(S3):270-283,2011

Potato Starch Modified 1 Final report 09/2015available from CIR

PPG-10-Ceteareth-20 1 not in current use* safe when formulatedto be non-irritating

Final report 09/2013Available from CIR

PPG-10 Lanolin Alcohol Ether 1 not in current use* Final amended report09/12 available from

CIRPPG-10 methyl glucose ether 1 Final report 09/2013

Available from CIR







PPG-11 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001

PPG-12 1 safe when formulatedto be non- irritating

JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012

PPG-12-Buteth-16 1 up to 31% IJT 19(S1):47-67,2000

PPG-12 Butyl Ether 1 safe when formulatedto be non- irritating

IJT 20(S4):39-52,2001

PPG-12 Butyl Ether Dimethicone* 1 Final report 12/2014available from CIR

PPG-12 Dimethicone 1 Final report 12/2014available from CIR

PPG-12-PEG-50 Lanolin 1 0.2 to 8% Final amended report09/12 available from

CIRPPG-12-PEG-65 Lanolin Oil 1 0.002 to 0.04% Final amended report



IJT 31(2) 245-260,2012

PPG-13-Decyltetradeceth-24 1 safe when formulatedto be non- irritating



IJT 20(S4):39-52,2001

PPG-14-Deceth-6 1 safe when formulatedto be non- irritating



JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012


IJT 20(S4):39-52,2001

PPG-15 Stearyl Ether 1 2 to 10% IJT 20(S4):53- 59,2001


IJT 31(2) 245-260,2012


IJT 20(S4):39-52,2001


JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012


IJT 20(S4):39-52,2001


IJT 20(S4):39-52,2001

PPG-1-Ceteth-1 1 not in current use* safe when formulatedto be non-irritating














PPG-1-Deceth-4 1 not in current use* safe when formulatedto be non-irritating








PPG-1-Isodeceth-4 1 not in current use* safe when formulatedto be non-irritating








PPG-1 Trideceth-13 1 not in current use* safe when formulatedto be non-irritating





JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012


IJT 20(S4):39-52,2001




CIRPPG-20 methyl glucose ether 1 Final report 09/2013

Available from CIRPPG-20 methyl glucose ether acetate 1 not in current use* Final report 09/2013

Available from CIRPPG-20 methyl glucose ether distearate 1 Final report 09/2013

Available from CIRPPG-20-PEG-20 Hydrogenated Lanolin 1 not in current use * Final amended report



IJT 20(S4):39-52,2001







PPG-23-Steareth-34 1 not in current use* safe when formulatedto be non-irritating



IJT 20(S4):39-52,2001

PPG-25 Diethylmonium Chloride 1 IJT 18(S3):57- 59,2000

PPG-25 Dimethicone* 1 Final report 12/2014available from CIR

PPG-25-Laureth-25 1 safe when formulatedto be non- irritating


PPG-25 methyl glucose ether 1 not in current use* Final report 09/2013Available from CIR


JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012

PPG-26-Buteth-26 1 2.5% IJT 19(S1):47-67,2000


IJT 20(S4):39-52,2001

PPG-27 Dimethicone* 1 Final report 12/2014available from CIR

PPG-28-Buteth-35 1 22% IJT 19(S1):47-67,2000


IJT 20(S4):39-52,2001

PPG-2 C12-13 Pareth-8 1 safe when formulatedto be non- irritating


PPG-2 C12-15 Pareth-6 1 not in current use* safe when formulatedto be non-irritating










PPG-2-Ceteareth-9 1 safe when formulatedto be non- irritating




PPG-2-Ceteth-10 1 safe when formulatedto be non- irritating




































PPG-2 Dimethicone 1 Final report 12/2014available from CIR


















CIRPPG-2-Laureth-12 1 not in current use* safe when formulated

to be non-irritatingFinal report 09/2013Available from CIR







PPG-2-Laureth-5 1 not in current use* safe when formulatedto be non-irritating




PPG-2 Methyl Ether 1 up to 2% IJT 28(S2): 162- 174,2009

PPG-2 Methyl Ether Acetate 1 not in current use * IJT 28(S2): 162-174,2009

PPG-2-PEG-11 Hydrogenated Lauryl Alcohol Ether 1 not in current use* safe when formulatedto be non-irritating



IJT 31(2) 245-260,2012


JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012


IJT 20(S4):39-52,2001


CIRPPG-30 Steareth-4 1 not in current use* safe when formulated



IJT 31(2) 245-260,2012


IJT 20(S4):39-52,2001


JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012

PPG-34-Steareth-3 1 safe when formulatedto be non- irritating


PPG-38 Steareth-6 1 not in current use* safe when formulatedto be non-irritating


PPG-3 C12-14 Sec-Pareth-7 1 safe when formulatedto be non- irritating


PPG-3-Isodeceth-1 1 safe when formulatedto be non- irritating


PPG-3-Isosteareth-9 1 safe when formulatedto be non- irritating
















PPG-3 Methyl Ether 1 concentration not reported * IJT 28(S2): 162-174,2009

PPG-3-Myreth-11 1 not in current use* safe when formulatedto be non-irritating


PPG-3-Myreth-3 1 not in current use* safe when formulatedto be non-irritating


PPG-3-PEG-6 Oleyl Ether 1 not in current use* safe when formulatedto be non-irritating



IJT 20(S4):39-52,2001

PPG-40 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999

PPG-40-PEG-60 Lanolin Oil 1 not in current use* Final amended report09/12 available from

CIRPPG-4 Butyl Ether 1 safe when formulated

to be non- irritatingIJT 20(S4):39-52,

2001PPG-4 C12-14 Sec-Pareth-5 1 safe when formulated

to be non- irritatingFinal report 09/2013Available from CIR

PPG-4 C13-15 Sec-Pareth-15 1 safe when formulatedto be non- irritating


PPG-4-Ceteareth-12 1 safe when formulatedto be non- irritating














PPG-4-Isodeceth-10 1 safe when formulatedto be non- irritating










PPG-4 Oleth-10 Dimethicone* 1 Final report 12/2014available from CIR







PPG-4-Tricedeth-6 1 safe when formulatedto be non- irritating



IJT 31(2) 245-260,2012


IJT 31(2) 245-260,2012


IJT 20(S4):39-52,2001


IJT 20(S4):39-52,2001


IJT 20(S4):39-52,2001

PPG-5 C12-14 Sec-Pareth-7 1 not in current use* safe when formulatedto be non-irritating


PPG-5 C12-14 Sec-Pareth-9 1 not in current use* safe when formulatedto be non-irritating







CIRPPG-5 Lanolin Wax 1 2.0 to 4.0% IJT 16(S3):307

-316, 1997; Finalamended report 09/12

Available from CIRPPG-5 Lanolin Wax Glyceride 1 not in current use* IJT 16(S3):307-316,

1997; Final amendedreport 09/12

Available from CIRPPG-5-Laureth-5 1 safe when formulated

to be non- irritatingFinal report 09/2013Available from CIR


IJT 31(2) 245-260,2012







PPG-6 Deceth-4 1 not in current use* safe when formulatedto be non-irritating


PPG-6 Deceth-9 1 not in current use* safe when formulatedto be non-irritating


PPG-6-Decyltetradeceth-12 1 not in current use* safe when formulatedto be non-irritating

















IJT 31(2) 245-260,2012














JACT 13(6):437-91,1994; IJT 31(2)245-260, 2012

PPG-9-Buteth-12 1 not in current use* IJT 19 (S1):47-67,2000


IJT 20(S4):39-52,2001

PPG-9 Diethylmonium Chloride 1 IJT 18(S3):57-59,1999

PPG-9-Ethylhexeth-5 1 not in current use* safe when formulatedto be non-irritating


PPG-9-Steareth-3 1 not in current use* safe when formulatedto be non-irritating


PPG greater than or equal to 3 0 Because PPGs of variouschain lengths are likely to

be added to the InternationalCosmetic Ingredient

Dictionary and Handbookin the future, the CIR

Expert Panel concludedthat any PPGgreater than

or equal to3 would be safefor use in cosmetics when

formulated to be non-ir

IJT 31(2) 245-260,2012

p-Phenylenediamine (amended)** 1 up to 0.04% Final AmendedReport 12/07








1985 (original report)p-Phenylenediamine HCl 1 not in current use* Final Amended


1985 (original report)p-Phenylenediamine Sulfate (amended) 1 not in current use* Final Amended


1985 (original report)Proline 1 0.00001 to 2% IJT 32(S4):41-64,

2013Propane 1 up to 24% JACT 1(4):127-42,


24(S1):52-55, 2005Propionyl collagen amino acids 1 not in current use* safe for use in cosmetics when


available from CIRPropyl Acetate 1 0.005 to 39% IJT 31(S1):112- 136,

2012Propyl Alcohol 1 0.0001 to 0.5% IJT 31(S1):112 -136,

2012Propyl Benzoate 1 not in current use * IJT 31 (3):342-372

(2012)Propylene Carbonate 1 up to 6% JACT 6(1):23-51,


2006Propylene Glycol 1 50% JACT 13(6):437-91,

1994; IJT 31(2)245-260, 2012

Propylene Glycol Alginate 1 Final report 09/2015available from CIR

Propylene Glycol Behenate* 1 safe when formulatedto be non- irritating


Propylene Glycol Capreth-4 1 not in current use* safe for use when formulatedto be non-irritating


Propylene Glycol Caprylate* 1 safe when formulatedto be non- irritating


Propylene Glycol Cocoate* 1 safe when formulatedto be non- irritating


Propylene Glycol Dicaprate 1 safe when formulatedto be non- irritating


from CIR







Propylene Glycol Dicaproate 1 safe when formulatedto be non- irritating


Propylene Glycol Dicaprylate 1 safe when formulatedto be non- irritating


from CIRPropylene Glycol Dicaprylate/dicaprate 1 safe when formulated


from CIRPropylene Glycol Dicocoate* 1 safe when formulated

to be non- irritatingIJT 18 (S2):35-52,1999; Final report12/2014 available

from CIRPropylene Glycol Diethylhexanoate 1 safe when formulated


available from CIRPropylene Glycol Diisononanoate* 1 safe when formulated

to be non- irritatingIJT 30(Suppl.

3):228-269, 2011;Final report 12/2014

available from CIRPropylene Glycol Diisostearate* 1 safe when formulated


from CIRPropylene Glycol Dilaurate* 1 safe when formulated


from CIRPropylene Glycol Dioleate 1 safe when formulated


from CIRPropylene Glycol Dipelargonate 1 safe when formulated


from CIRPropylene Glycol Distearate* 1 safe when formulated


available from CIRPropylene Glycol Diundecanoate* 1 safe when formulated


available from CIRPropylene Glycol Heptanoate* 1 safe when formulated


available from CIRPropylene Glycol Isodeceth-12 1 not in current use* safe for use when formulated


Propylene Glycol Isodeceth-4 1 not in current use* safe for use when formulatedto be non-irritating


Propylene Glycol Isostearate 1 safe when formulatedto be non- irritating

IJT 18(S2):35-52,1999; Final report








Propylene Glycol Laurate 1 safe when formulatedto be non- irritating


from CIRPropylene Glycol Laureth-6 1 not in current use* Final report 09/2013

Available from CIRPropylene Glycol Linoleate* 1 safe when formulated


available from CIRPropylene Glycol Linolenate* 1 safe when formulated


available from CIRPropylene Glycol Myristate 1 safe when formulated

to be non- irritatingIJT 18 (S2):35-52,

1999; IJT29(S3) :162-186,2010;


Propylene Glycol Oleate 1 safe when formulatedto be non- irritating


from CIRPropylene Glycol Oleate SE 1 up to 50% IJT 18 (S2):35-52,

1999Propylene Glycol Oleate SE (self-emulsifying)* 1 safe when formulated


available from CIRPropylene Glycol Oleth-5 1 not in current use* safe as used when formulated


Propylene Glycol Soyate* 1 safe when formulatedto be non- irritating


Propylene Glycol Stearate 1 safe when formulatedto be non- irritating

JACT 2 (5):101-124,1983 confirmed


available from CIRPropylene Glycol Stearate SE 1 safe when formulated

to be non- irritatingJACT 2(5):101-124,


24(S1):85-87, 2005;Final report 12/2014

available from CIRPropyl Gallate (Amended) 1 0.10% IJT 26(S3) 2007


Propyl Glycolate 1 Glycolic and Lactic Acid,their common salts and their


IJT 17(S1):1-242,1998










Propylheptyl Caprylate 1 safe as used in cosmeticswhen formulated



Propylparaben (amended) 1 up to 0.4% if used alone;parabens mixture up to 0.8%

IJT 27(S4): 1-82,2008 JACT


Prunus Amygdalus Dulcis (Sweet Almond) Oil 1 0.0001 to 77% Final amended report03/11 available

from CIR; JACT2(5):85-99, 1983;

re-review IJT24(S1):98-101, 2005

Prunus Amygdalus Dulcis (Sweet Almond) OilUnsaponifiables

1 not in current use * Final report 03/11available from CIR

Prunus Amygdalus Dulcis (Sweet Almond) Seed Meal (akaAlmond Meal)


11/02 IJT24(S1):98-101, 2005

Prunus Armeniaca (Apricot) Kernel Oil 1 0.00001 to 89% Final report 03/11available from CIR

Prunus Armeniaca (Apricot) Kernel Oil Unsaponifiables 1 not in current use * Final report 03/11available from CIR

Prunus Avium (Sweet Cherry) Seed Oil 1 0.01 to 0.02% Final report 03/11available from CIR

Prunus Domestica Seed Oil 1 up to 0.04% Final report 03/11available from CIR

Prunus Persica (Peach) Gum 1 Final report 09/2015available from CIR

Prunus Persica (Peach) Kernel Oil 1 0.003 to 22% Final report 03/11available from CIR

Pseudoalteromonas exopolysaccharides 1 not in current use* Final report 09/12available from CIR

Pueraria Lobata Starch 1 Final report 09/2015available from CIR

Pullulan 1 0.03 to 17% Final report 09/12available from CIR

Pumpkin Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Punica Granatum Seed Oil 1 0.001 to 1% Final report 03/11available from CIR







Punica Granatum Sterols 1 not in current use* Final report 12/2013available from CIR

PVM/MA Copolymer (amended) 1 up to 13% IJT 30 (S2):128-144,2011

PVP 1 up to 35% IJT 17 (S4):95-130,1998

PVP/Dimethylaminoethyl Methacrylate Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Pyrocatechol (Amended) 1 1 carcinogen; potentialco- carcinogen. NOTE:

for hair dyes, insuff.data to support safety.

IJT16(S1):11-58,1997JACT 5(3):123-65,

1986 (OriginalReport)

Pyrogallol 1 up to 5% JACT 10(1):67-85,1991

Pyromallitic Glycidyl Dimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Pyrophyllite 1 not in current use* IJT 22 (S1):37-102,2003

Pyrus Malus (Apple) Bark Extract* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Carpel Powder* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Fiber* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Flower Extract 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Fruit 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Fruit Extract 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Fruit Water 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Juice 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Leaf Extract* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Pectin Extract 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Peel Extract* 1 when formulated to be non-irritating and non-sensitizing








Pyrus Malus (Apple) Peel Powder 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Peel Wax* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Pulp Extract* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Root Bark Powder* 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Root Extract 1 Final report 03/2016available from CIR

Pyrus Malus (Apple) Seed Extract 1 when formulated to be non-irritating and non-sensitizing


Pyrus Malus (Apple) Seed Oil X concentration not reported* Final report 03/11available from CIR

Pyrus Malus (Apple) Stem Extract* 1 Final report 03/2016available from CIR

Quassin 1 IJT 27 (S1):1-43,2008

Quaternium-15 (amended) 1 safe at concentrationsnot to exceed 0.2%

JACT 5(3):61-101,1986 (original

report); Amendedsafety assessment03/09 - Available

from CIR; confirmed03/2011

Quaternium-18 1 up to 2% JACT 1(2):71-83,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Quaternium-18/benzalkonium Bentonite* 1 safe as used when formulatedto be non-irritating


Quaternium-18 Bentonite 1 up to 9% JACT 1 (2):71-83,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Quaternium-18 Hectorite (amended) 1 0.05 to 5% in leave-on; concentration notreported for rinse-off

IJT 32(S4):33-40,2013 ; JACT

1(2):71-83 (originalreport), 1982

confirmed 11/01 IJT22(S1):1-35, 2003

Quaternium-22 1 up to 5% JACT 14(6):485-97,1995 confirmed

04/10Quaternium-26 1 should not be used in


IJT 19(S1):69-75,2000







Quaternium-90 Bentonite 1 safe as used when formulatedto be non-irritating


Quaternium-90 Montmorillonite 1 safe as used when formulatedto be non-irritating


Quaternium-90 Sepiolite 1 safe as used when formulatedto be non-irritating


Rapeseed Acid 1 not in use at the time* Final report 03/11available from CIR

Rapeseed oil PEG-20 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Rapeseed oil PEG-3 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT33(Spump4):13-39,

2014Raspberry seed oil PEG-8 esters 1 safe for use in cosmetics when


2014Resorcinol 1 up to 5% JACT 5(3):167-203,

1986 confirmed12/06

Retinol 1 up to 5% JACT 6(3):279-320,1987 confirmed

06/05Retinyl Palmitate 1 up to 5% JACT 6(3):279-320,

1987 confirmed06/06

Rhamnose 1 Final report 03/2014available from CIR

Rhizobian gum 1 concentration not reported* Final report 09/12available from CIR

Rhus Succedanea Fruit Wax 0 up to 34% JACT 3 (3):1-41,1984 confirmed

06/03 IJT24(S1):48-52, 2005

Ribes Nigrum (Black Currant) Seed Oil 1 0.000001 to 0.3% Final report 03/11available from CIR

Ribes Rubrum (Currant) Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Ribose 1 Final report 03/2014available from CIR

Rice Amino Acids 1 IJT 33(S4):5-12,2014

Rice bran Acid 1 not in use at the time* Final report 03/11available from CIR

Ricebranamide DEA 1 safe in the present practices ofuse and concentration when


considered safe int the CIR

IJT 32(S1):36-58,2013







safety assessment of DEAand its salts; should not beused in cosmetic products

Ricinoleamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Ricinoleamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Ricinoleamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Ricinoleamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Ricinoleic Acid 1 concentration not reported* IJT 26(S3) 2007Ricinus Communis (Castor) Seed Oil 1 up to 81% IJT 26(S3) 2007Rosa Canina Fruit Oil 1 0.001 to 19% Final report 03/11

available from CIRRosmarinus officinalis (rosemary) extract 1 safe for use in cosmetics

when formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) flower/leaf/stem extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) flower/leaf/stem water 1 not in current use* safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) flower extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.








Rosmarinus officinalis (rosemary) leaf 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) leaf extract 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) leaf oil 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) leaf powder 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) leaf water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rosmarinus officinalis (rosemary) water 1 safe for use in cosmeticswhen formulated tobe non-sensitizing.


Rubus Chamamorus Seed Oil 1 up to 0.1% Final report 03/11available from CIR

Rubus Idaeus (Raspberry) Seed Oil 1 0.1 to 5% Final report 03/11available from CIR

Safflower (Carthamus Tinctorius) Oil 1 up to 84% JACT 4(5):171-97,1985 confirmed

02/04 IJT 25(S2),2006

Safflower Acid 1 Final report 03/11available from CIR

Safflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Salicylic Acid 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

Schinziophyton Rautaneii Kernel Oil 1 concentration not reported* Final report 03/11available from CIR

Schinziophyton Rautanenii Kernel Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Sclerocarya Birrea Seed Oil 1 up to 1% Final report 03/11available from CIR

Sclerocarya Birrea Seed Oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Sclerotium gum 1 0.003 to 2% Final report 09/12available from CIR







SD Alcohol 30 1 not in current use* IJT 27 (S1):1-43,2008

SD Alcohol 39 1 IJT 27 (S1):1-43,2008

SD Alcohol 39-B 1 concentration not reported* IJT 27 (S1):1-43,2008

SD Alcohol 39-C 1 up to 88% IJT 27 (S1):1-43,2008

SD Alcohol 3-A 1 up to 5% IJT 27 (S1):1-43,2008

SD Alcohol 40 1 IJT 27 (S1):1-43,2008

SD Alcohol 40-B 1 up to 99% IJT 27 (S1):1-43,2008

SD Alcohol 40C 1 not in use at the time* IJT 27 (S1):1-43,2008

SD Alcohol 40-C 1 not in current use* IJT 27 (S1):1-43,2008

Sebacic Acid 1 up to 0.03% in leave-on; up to 1% in rinse- off

IJT 31 (S1):5-76,2012

Sericin 1 Final report 12/2015available from CIR

Serine 1 0.00003 to 2% IJT 32(S4):41-64,2013

Sesame Amino Acids 1 IJT 33(S4):5-12,2014

Sesame Seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Sesamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Sesamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Sesamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which









Sesamum Indicum (Sesame) Seed Butter 1 not in use at the time* Final report 03/11available from CIR

Sesamum Indicum (Sesame) Seed Oil (amended) 1 0.0001 to 73% Final amended report03/11 available

from CIR; JACT12(3):261-77, 1993

(original report); IJT30 (1): 40-53, 2011

(amended)Sesamum Indicum (Sesame) Seed Oil Unsaponifiables(amended)

1 0.01 to 0.03% Final amended report03/11 available

from CIR; JACT12(3):261-77, 1993


(amended)Shea butteramide/castoramide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013

Shea butteramidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Shellac 1 6% JACT 5(5):309-327,1986 confirmed

12/06; IJT30(S2):73-127, 2011

Silica (amorphous) 1 up to 44% Final Report 09/09available from CIR

Silica dimethyl silylate 1 safe when formulatedand delivered in the

final product not to beirritating or sensitizingto the respiratory tract

IJT 32(S1):5-24,2013

Silica silylate 1 safe when formulatedand delivered in the


IJT 32(S1):5-24,2013

Silicone quaternium-16/glycidoxy dimethicone crosspolymer 1 0.003 to 3% IJT 33 (S2): 65-115,2014







Silk 1 Final report 12/2015available from CIR

Silk amino acids 1 IJT 33(S4):5-12,2014

Silk Extract 1 Final report 12/2015available from CIR

Silk Powder 1 Final report 12/2015available from CIR

Silver borosilicate 1 not in current use* IJT 32(S3): 65-72,2013

Silybum Marianum Seed Oil [Thistle] 1 up to 0.5% Final report 03/11available from CIR

Simmondsia Chinensis (Jojoba) Butter (amended) 1 up to 6% Amended FinalReport 09/08 -

available from CIRSimmondsia Chinensis (Jojoba) Seed Oil (amended) 1 up to 100% Amended Final

Report 09/08 -available from CIRJACT 11(1):57-74,

1992 (original report)Simmondsia Chinensis (Jojoba) Wax (amended) 1 up to 2% Amended Final

Report 09/08 -available from CIRJACT 11(1):57-74,

1992 (original report)Sodium/TEA C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulated

to be non-irritating. Theingredients should not

be used in cosmeticproducts in which N-nitroso

compounds can be found

IJT 32(S1): 59-81,2013

Sodium/TEA-lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


sodium/TEA-lauroyl keratin amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium/TEA-Undecylenoyl Alginate 1 Final report 09/2015available from CIR

Sodium/TEA-Undecylenoyl Carrageenan 1 Final report 09/2015available from CIR

sodium/TEA-undecylenoyl collagen amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Acetate 1 0.0002 to 0.5% IJT 31(S1):112 -136,2012

Sodium Acrylates/Acrolein Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Sodium Acrylates/C10-30 Alkyl Acrylate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene








Sodium Acrylates/Vinyl Isodecanoate Crosspolymer 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Sodium Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Sodium Acrylates Crosspolymer-2 1 safe in the present practices ofuse and concentration whennot polymerized in benzene


Sodium Algin Sulfate 1 Final report 09/2015available from CIR

Sodium Alpha-Olefin Sulfonates (e.g. C12-14 Olefin) 1 safe as used in rinse offproducts; safe up to 2% in

leave ons; the gamma sultoneimpurities should not exceed

10 ppm for unsubstitutedalkane sultones, 1 ppm for

chlorosultones, and 0.1 ppmfor unsaturated sultones

IJT 17(S5):39-66,1998

Sodium Ascorbate 1 up to 0.3% IJT 24(2):51-111,2005

Sodium Ascorbyl Phosphate 1 up to 3% IJT 24 (2):51-111,2005

Sodium Aspartate 1 not in current use* IJT 32(S4):41-64,2013

Sodium Astrocaryum Murumuruate 1 0.002 to 0.005% Final report 03/11available from CIR

Sodium Avocadoate 1 concentration not reported* Final report 03/11available from CIR

Sodium Babassuate 1 8% Final report 03/11available from CIR

Sodium Benzoate 1 0.000001 to 1% Amended finalreport available

from CIR 09/11; IJT20(S3):23-50, 2001

Sodium Benzotriazolyl Butylphenol Sulfonate 1 safe as used Final report 03/2015available on CIR

Sodium Bicarbonate 1 greater than 50% JACT 6 (1):121-138,1987 confirmed

03/05 IJT 25(S2),2006

Sodium Bisulfite 1 up to 0.7% IJT 22(S2):63-88,2003

Sodium Borate 1 5%; but not for use oninfant or injured skin


06/03 IJT 25(S2),2006

Sodium Bromate 1 10.17% JACT 13(5):400-14,1994







Sodium Butyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09


1993 (original report)Sodium C10-15 Pareth Sulfate 1 safe when formulated


29(S3) :151-161,2010Sodium C12-13 Pareth Sulfate 1 safe when formulated


29(S3) :151-161,2010Sodium C12-14 Olefin Sulfonate 1 safe as used in rinse off

products; safe up to 2% inleave ons; the gamma sultoneimpurities should not exceed



IJT 17(S5):39-66,1998

Sodium C12-15 Pareth Sulfate 1 safe when formulatedto be non- irritating

IJT29(S3) :151-161,2010

Sodium C14-16 Olefin Suifonate 1 safe as used in rinse offproducts; safe up to 2% in




IJT 17(S5):39-66,1998

Sodium C14-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in




IJT 17(S5):39-66,1998

Sodium C16-18 Olefin Sulfonate 1 safe as used in rinse offproducts; safe up to 2% in




IJT 17(S5):39-66,1998

Sodium Caproyl Methyltaurate* 1 when formulatedto be non-irritating


Sodium caproyl prolinate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating








sodium capryloyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Carbonate 1 up to 25% JACT 6(1):121-38,1987 confirmed

03/05 IJT 25(S2),2006

Sodium carboxymethyl beta-glucan 1 0.0001 to 0.1% Final report 09/12available from CIR

Sodium carboxymethyl dextran 1 concentration not reported* Final report 09/12available from CIR

Sodium Carboxymethyl Inulin 1 Final report 09/2015available from CIR

Sodium Carboxymethyl Starch 1 Final report 09/2015available from CIR

Sodium Carrageenan 1 Final report 09/2015available from CIR

Sodium Cellulose Sulfate 1 not in use at the time* Amended safetyassesment 03/09

available from CIRSodium Cetearyl Sulfate 1 up to 10% IJT 29(S2): 115-132,

2010 JACT11(1):145-55, 1992

(original report)Sodium Cetyl Sulfate 1 up to 2% IJT 29(S2): 115-132,

2010Sodium citrate 1 0.000005 to 10% IJT 33 (S2): 16-46,

2014Sodium Coceth Sulfate 1 safe in the present practices of


IJT29(S3) :151-161,2010

Sodium Coco/Hydrogenated Tallow Sulfate (amended) 1 not in current use* Amended FinalReport 09/08

Available from CIRSodium Cocoa Butterate 1 not in use at the time* Final report 03/11

available from CIRSodium Cocoamphoacetate 1 0.09 to 18% JACT 9 (2):121-142,

1990; re-review IJT27(Suppl. 1):77-142,

2008Sodium Cocoamphopropionate 1 0.3 to 10% JACT 9 (2):121-142,

1990; re-review IJT27(Suppl. 1):77-142,

2008Sodium Cocoate (amended) 1 1 to 52% IJT 30 (S1):5S-16SSodium Cocomonoglyceride Sulfate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Coco-Sulfate 1 up to 29% IJT 29(S2): 115-132,

2010







Sodium cocoyl/hydrogenated tallow glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


sodium cocoyl/palmoyl/sunfloweroyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl Alaninate 1 safe for use in cosmeticswhen formulated



Sodium Cocoyl Amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl Apple amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl barley amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium cocoyl glycinate 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl Isethionate 1 safe in the present practices ofuse and concentration when


JACT 12(5):459-79,1993 reopened 03/09;


sodium cocoyl oat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


sodium cocoyl proline 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Cocoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Sodium Cocoyl Taurate 1 when formulatedto be non-irritating


Sodium cocoyl threoninate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium cocoyl wheat amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Cumenesulfonate 1 up to 3% IJT 30 (S3):270-283,2011







Sodium Deceth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Sodium Decylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

JACT 12(3):279-309,1993 (original

report); IJT 29 (S4)288-305, 2010

Sodium Decyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010

Sodium Dehydroacetate 1 up to 0.6% JACT 4 (3):123-159,1985 confirmed

11/03 IJT 25(S2),2006

Sodium dextran sulfate 1 0.005 to 0.5% Final report 09/12available from CIR

Sodium Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR

Sodium Dodecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

JACT 12(3):279-309,1993 (original

report); IJT 29 (S4)288-305, 2010

Sodium Erythorbate 1 up to 1% IJT 18(S3):1-26,1999

Sodium Ethyl Ester of PVM/MA Copolymer (amended) 1 not in current use* Amended FinalReport 06/09


1993 (original report)Sodium Ethylhexyl Sulfate 1 not in current use* IJT 29(S2): 115-132,

2010Sodium Formate 1 Final report 12/2013

available from CIRSodium Fumarate 1 not in current use* Final report 03/09

available from CIRSodium Gluconate 1 Final report 03/2014

available from CIRSodium Glutamate 1 0.01 to 2% IJT 32(S4):41-64,

2013Sodium Glycinate 1 concentration not reported* IJT 32(S4):41-64,

2013Sodium Glycolate 1 Glycolic and Lactic Acid,

their common salts and theirsimple esters, are safe foruse in cosmetic products


than or equal to3.5, when

IJT 17(S1):1-242,1998







formulated to avoid increasingsun sensitivity or when

directions for use includeSodium Grapeseedate 1 concentration not reported* Final report 12/10

available from CIRSodium Hexametaphosphate 1 safe for use when formulated

to avoid skin irritationIJT 20(S3):75-89,

2001Sodium Hyaluronate 1 up to 2% IJT 28 (1): 5- 67,

2009Sodium Hydrogenated Cocoate (amended) 1 not in current use* IJT 30(S1):5S-16SSodium Hydrogenated Cocoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when


available from CIRSodium Hydrogenated Palmate 1 not in use at the time* Final report 03/11

available from CIRSodium hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics when


available from CIRSodium Hydrolyzed Potato Starch Dodecenylsuccinate 1 Final report 09/2015

available from CIRSodium Hydroxide 1 safe in hair straighteners and

depilatories under conditionsof recommended use: users




Sodium Hydroxypropyl Oxidized Starch Succinate 1 Final report 09/2015available from CIR

Sodium Iodate 1 JACT 14(3):231-39,1995

Sodium Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Lactate 1 Glycolic and Lactic Acid,their common salts and their





IJT 17(S1):1-242,1998

Sodium Laneth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Sodium Lauraminopropionate 1 IJT 16(S1):1-10,1997







Sodium Laureth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Sodium Lauriminodipropionate 1 0.05% (rinse-off) IJT 32 (S3):49-55,2013; original report

IJT 16(S1):1-10,1997Sodium lauroyl/myristoyl aspartate 1 not in current use* safe for use in cosmetics when


available from CIRSodium lauroyl aspartate 1 safe for use in cosmetics when


available from CIRSodium lauroyl collagen amino acids 1 not in current use* safe for use in cosmetics when


available from CIRSodium lauroyl glutamate 1 safe for use in cosmetics when


available from CIRSodium Lauroyl Isethionate 1 safe for use in cosmetics when


available from CIRSodium Lauroyl Methyl Isethionate 1 safe for use in cosmetics when


available from CIRSodium lauroyl millet amino acids 1 not in current use* safe for use in cosmetics when


available from CIRSodium lauroyl oat amino acids 1 safe for use in cosmetics when


available from CIRSodium Lauroyl Sarcosinate 1 safe as used in rinse-off



IJT 20(S1):1-14,2001

Sodium lauroyl silk amino acids 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Lauroyl Taurate 1 when formulatedto be non-irritating


Sodium lauroyl wheat amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Lauryl Phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Lauryl Sulfate 1 safe for use in rinse-off products; but 1%for leave-on products


06/02 IJT24(S1):89-98, 2005

Sodium Lauryl Sulfoacetate 1 up to 21% JACT 6 (3):261-277,1987 confirmed

12/04 IJT 25(S2),2006







Sodium Macadamiaseedate 1 not in use at the time* Final report 03/11available from CIR

Sodium Magnesium Silicate 1 up to 5% IJT 22 (S1):37-102,2003

Sodium Malate 1 safe for use as pH adjusters;insufficient data to support

safety for other uses

IJT 20(S1):47-55,2001

Sodium Mangoseedate 1 concentration not reported* Final report 03/11available from CIR

Sodium Metabisulfite 1 up to 14% IJT 22(S2):63 -88,2003

Sodium Metaphosphate 1 safe for use when formulatedto avoid skin irritation

IJT 20(S3):75-89,2001

Sodium Metasilicate 1 up to 14% safe for use when formulatedto avoid skin irritation

IJT 24(S1):103-117,2005

Sodium methyacrylate/styrene copolymer 1 not in current use* Final report 09/2014available from CIR

Sodium Methyl Cocoyl Taurate 1 when formulatedto be non-irritating


Sodium Methyl Isethionate 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Methyl Lauroyl Taurate 1 when formulatedto be non-irritating


Sodium Methyl Myristoyl Taurate 1 when formulatedto be non-irritating


Sodium Methyl Oleoyl Taurate 1 when formulatedto be non-irritating


Sodium Methyl Palmitoyl Taurate 1 when formulatedto be non-irritating


Sodium Methyl Stearoyl Taurate 1 when formulatedto be non-irritating


Sodium Methyltaurate 1 when formulatedto be non-irritating


Sodium Methyltaurate Isopalmitamide* 1 when formulatedto be non-irritating


Sodium Methyltaurine Cocoyl Methyltaurate 1 when formulatedto be non-irritating


Sodium-m-Nitrobenzenesulfonate 1 JACT 15(4):337-47,1996

Sodium Myreth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Sodium Myristate 1 up to 6% IJT 29(S3):162-186,2010

Sodium myristoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating








Sodium Myristoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Myristoyl Sarcosinate 1 safe as used in rinse-offproducts; but 5% in leave-on products. Should not beused in products where N-nitroso compounds may beformed. Insufficient data todetermine safety in products


IJT 20(S1):1-14,2001

Sodium Myristyl Sulfate 1 concentration not reported* IJT 29(S2): 115-132,2010

Sodium Naphthalenesulfonate (amended) 1 below 2% safe as used in cosmeticformulations intended tobe applied to skin; but

insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.

IJT 22(S2):37-44,2003

Sodium N-isostearoyl Methyltaurate* 1 when formulatedto be non-irritating


Sodium Octoxynol-2 Ethane Sulfonate 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004

Sodium Octoxynol-2 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004

Sodium Octoxynol-6 Sulfate 1 not in current use* safe as used in rinse-off products; safe at 5%


IJT 23(S1):59-111,2004

Sodium Octoxynol-9 Sulfate 1 not in current use* IJT 23(S1):59-111,2004

Sodium Oleoyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Oleth Sulfate 1 safe in the present practices ofuse and concentration when


IJT29(S3) :151-161,2010

Sodium Oleyl Methyl Isethionate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Oleyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010

Sodium Olivate 1 4 to 18% Final report 03/11available from CIR

Sodium olivoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Oxidized Starch Acetate/Succinate 1 Final report 09/2015available from CIR







Sodium Palmate 1 3 to 68% Final report 03/11available from CIR

Sodium palmitoyl proline 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium Palm Kernelate 1 12 to 44% Final report 03/11available from CIR

Sodium Palm Kerneloyl Isethionate 1 not in current use* Final report 09/2013available from CIR

Sodium palmoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


Sodium PCA 1 should not be used in cosmeticproducts in which N-nitrosocompounds can be formed


from CIRSodium p-Chloro-m-Cresol (amended) 1 up to 0.5% IJT 25(S1):29-127,

2006Sodium Peanutate 1 not in current use* Final report 03/11

available from CIRSodium PEG-50 hydrogenated castor oil succinate 1 safe for use in cosmetics when


2014Sodium Persulfate 1 safe as oxidizing agents

in hair colorants andlighteners designed forbrief, discontinuous usefollowed by thorough


IJT 20(S3):7-21,2001

Sodium Picramate (amended) 1 concentration not reported* IJT 28(S3): 205-216,2009 JACT


Sodium Polyacrylate 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Sodium Polynaphthalenesulfonate (amended) 1 safe as used in cosmeticformulations intended to be

applied to skin (0.3% is max.use concentration reportedin skin care products); but

insufficient data to support thesafety in cosmetic productswhich may contact mucousmembranes or be ingested.

IJT 22(S2):37-44,2003

Sodium Potassium Aluminum Silicate 1 up to 4% Final Report 09/09available from CIR

Sodium rapeseedate 1 not in current use* Final report 03/11available from CIR

Sodium Ricinoleate 1 concentration not reported* IJT 26(S3): 31-77,2007







Sodium Safflowerate 1 not in current use* Final report 03/11available from CIR

Sodium Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108,2003

Sodium Sesameseedate (amended) 1 not in current use* Final amended report03/11 available

from CIR; JACT12(3):261-77, 1993


(amended)Sodium Sesquicarbonate 1 greater than 50% JACT 6(1):121-38,


2006Sodium Silicate 1 up to 35% safe for use when formulated

to avoid skin irritationIJT 24(S1):103-117,

2005Sodium Soyate 1 not in current use* Final report 03/11

available from CIRSodium Starch Octenylsuccinate 1 Final report 09/2015

available from CIRSodium Stearate 1 up to 25% JACT 1(2):143-77,


22(S1):1-35, 2003Sodium stearoyl glutamate 1 safe for use in cosmetics when


available from CIRSodium Stearoyl Methyl Isethionate 1 not in current use* safe for use in cosmetics when


available from CIRSodium Stearyl Fumarate. 1 not in current use* Final report 03/09

available from CIRSodium Stearyl Sulfate 1 not reported* IJT 29 (S2): 115-132,

2010Sodium styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer


Sodium Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available

from CIRSodium Succinate 1 concentration not reported* IJT 31 (S1):5-76,

2012Sodium Sulfate 1 up to 1% in leave-

on formulationsIJT 19(S1):77-87,

2000







Sodium Sulfite 1 up to 3% IJT 22(S2):63-88,2003

Sodium Sweet Almondate 1 up to 15% Final report 03/11available from CIR

Sodium Tallate 1 concentration not reported* IJT 28(S3):252-258,2009

Sodium Tallow Sulfate 1 not in current use* IJT 29(S2): 115-132,2010

Sodium Taurate* 1 when formulatedto be non-irritating


Sodium Taurine Cocoyl Methyltaurate* 1 when formulatedto be non-irritating


Sodium Theobroma Grandiflorum Seedate 1 not in current use* Final report 03/11available from CIR

Sodium Thioglycolate 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair



IJT 28(S3):68-133,2009

Sodium Tocopheryl Phosphate 1 Final report 03/2014available from CIR

Sodium Toluenesulfonate 1 not in current use* IJT 30(S3):270-283,2011

Sodium Trideceth Sulfate 1 up to 19% IJT29(S3) :151-161,2010

Sodium Tridecylbenzenesulfonate 1 safe as cosmetic ingredientsin the present practices of


IJT 29(S4):288-305,2010

Sodium Tridecyl Sulfate 1 not in current use* IJT 29(S2): 115-132,2010

Sodium Trimetaphosphate 1 safe for use when formulatedto avoid skin irritation

IJT 20(S3):75-89,2001

Sodium undecylenoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Sodium Xylenesulfonate 1 up to 15% IJT 30 (S3):270-283,2011

Solanum Lycopersicum (Tomato) Fruit Oil 1 0.01 to 1% Final report 03/11available from CIR

Solanum Lycopersicum (Tomato) Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Solanum Tuberosum (Potato) Starch 1 Final report 09/2015available from CIR







Sorbeth-12 hexacocoate* 1 safe as used when formulatedto be non-irritating


Sorbeth-150 hexastearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-160 tristearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2/oleate/dimer dilinoleate crosspolymer* 1 safe as used when formulatedto be non-irritating


Sorbeth-20 beeswax 1 safe as used when formulatedto be non-irritating


Sorbeth-20 pentaisostearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-20 tetraisostearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 beeswax* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 cocoate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 hexacaprylate/caprate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 hexaisostearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 hexalaurate* 1 safe as used when formulatedto be non-irritating


Sorbeth-2 hexaoleate* 1 safe as used when formulatedto be non-irritating




Sorbeth-30 tetraisostearate 1 safe as used when formulatedto be non-irritating


Sorbeth-30 tetraoleate 1 safe as used when formulatedto be non-irritating


Sorbeth-30 tetraoleate laurate (PEG-30 sorbitol tetraoleatelaurate)*

1 safe as used when formulatedto be non-irritating


Sorbeth-3 isostearate* 1 safe as used when formulatedto be non-irritating




Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000

Sorbeth-40 Hexaoleate 1 concentration not reported* IJT 19(S2):43-89,2000

Sorbeth-40 hexaoleate (PEG-40 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating










Sorbeth-40 pentaoleate* 1 safe as used when formulatedto be non-irritating










Sorbeth-50 hexaoleate (PEG-50 sorbitol hexaoleate)* 1 safe as used when formulatedto be non-irritating








Sorbeth-60 tetrastearate (PEG-60 sorbitol tetrastearate)* 1 safe as used when formulatedto be non-irritating


Sorbeth-6 beeswax 1 safe as used when formulatedto be non-irritating


Sorbeth-6 hexastearate* 1 safe as used when formulatedto be non-irritating


Sorbeth-6 laurate* 1 safe as used when formulatedto be non-irritating




Sorbeth-8 beeswax* 1 safe as used when formulatedto be non-irritating


Sorbeth Tetraoleate Laurate 1 concentration not reported* IJT 19(S2):43-89,2000

Sorbeth Tetrastearate 1 concentration not reported* IJT 19(S2):43-89,2000

Sorbic Acid 1 up to 5% JACT 7(6):837-80,1988 confirmed

04/06Sorbitan Caprylate 1 IJT 21(S1):93-112,


from CIRSorbitan Cocoate* 1 IJT 21 (S1):93-112,


from CIRSorbitan Diisostearate* 1 IJT 21(S1):93-112,

2002; Final report








Sorbitan Dioleate* 1 IJT 21 (S1):93-112,2002; Final report12/2014 available

from CIRSorbitan Distearate* 1 IJT 21(S1):93-112,


from CIRSorbitan Isostearate 1 IJT 21(S1):93-112,


from CIRSorbitan Laurate 1 JACT 4(3):65-121,


from CIRSorbitan Oleate 1 JACT 4(3):65-121,


from CIRSorbitan Olivate 1 IJT 21(S1):93- 112,


from CIRSorbitan Palmate 1 Final report 12/2014

available from CIRSorbitan Palmitate 1 JACT 4(3):65-121,


from CIRSorbitan Sesquicaprylate* 1 Final report 12/2014

available from CIRSorbitan Sesquiisostearate 1 IJT 21 (S1):93-112,


from CIRSorbitan Sesquioleate 1 JACT 4(3):65 -121,


from CIRSorbitan Sesquistearate* 1 IJT 21(S1):93-112,


from CIRSorbitan Stearate 1 JACT 4(3):65-121,

1985; Final report








Sorbitan Triisostearate 1 IJT 21(S1):93-112,2002; Final report12/2014 available

from CIRSorbitan Trioleate 1 JACT 4(3):65-121,


from CIRSorbitan Tristearate 1 JACT 4(3):65-121,


from CIRSorbitan Undecylenate* 1 Final report 12/2014

available from CIRSoy Acid 1 not in current use* Final report 03/11

available from CIRSoyamide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013

Soyamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Soyamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Soy Amino Acids 1 IJT 33(S4):5-12,2014

Soybean oil PEG-20 ester 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Soybean Oil PEG-36 Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Soybean Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Soybean Oil Propylene Glycol Esters* 1 safe when formulatedto be non-irritating








Soy sterol acetate 1 Final report 12/2013available from CIR

Soytrimonium chloride 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Spirulina Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Squalane 1 up to 31% JACT 1(2):37-56,1982 confirmed

09/01 IJT22(S1):1-35, 2003

Squalene 1 up to 10% JACT 1(2):37-56,1982 confirmed

09/01 IJT22(S1):1-35, 2003

Starch Acetate 1 Final report 09/2015available from CIR

Starch Acetate/Adipate 1 Final report 09/2015available from CIR

Starch Diethylaminoethyl Ether 1 Final report 09/2015available from CIR

Starch Hydroxypropyltrimonium Chloride 1 Final report 09/2015available from CIR

Starch Laurate 1 Final report 09/2015available from CIR

Starch Tallowate 1 Final report 09/2015available from CIR

Steapyrium Chloride 1 0.1 to 3% JACT 10(1):87-97, 1991; IJT

30(S2):73-127, 2011Stearalkonium Bentonite 1 safe as used when formulated


available from CIRStearalkonium Chloride 1 up to 7% JACT 1(2):57 -69,


22(S1):1-35, 2003Stearalkonium Hectorite (amended) 1 0.006 to 6% IJT 32(S4):33-40,

2013; IJT19(S2):91-98, 2000

(original report)Stearamide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013







Stearamide DIBA-Stearate 1 IJT 20(S3):91-97,2001

Stearamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Stearamidopropyl Betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Stearamidopropyl Dimethicone 1 not in current use* IJT 22(S2):11-35,2003

Stearamidopropyl Dimethylamine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which



Stearamine 1 JACT 14(3):196-203,1995

Stearamine Oxide 1 safe for use in rinse-off products; but 5%for leave-on products


09/09; IJT30(S2):73-127, 2011

Steareth-1 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Steareth-10 Allyl Ether/Acrylates Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)









IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Steareth-60 Cetyl Ether 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)









IJT 31(S2):169-244(2012)

Stearic Acid 1 greater than 50% JACT 6(3):321-401, 1987 confirmed

06/05 IJT 25(S2),2006

Stearic Hydrazide 1 JACT 10(1):99-101,1991

Stearoxy Dimethicone 1 IJT 22(S2):11- 35,2003; Final report12/2014 available

from CIRStearoxymethicone/dimethicone Copolymer 1 Final report 12/2014

available from CIRStearoxypropyltrimonium chloride 1 safe when formulated


(2012)Stearoyl ethyltrimonium methosulfate 1 safe when formulated

to be non-irritatingIJT 31(S3): 296-341

(2012)Stearoyl glutamic acid 1 not in current use* safe for use in cosmetics when


available from CIRStearoyl Inulin 1 Final report 09/2015

available from CIRStearoyl leucine 1 not in current use* safe for use in cosmetics when


available from CIRStearoyl Sarcosine 1 safe as used in rinse-off



IJT 20(S1):1-14,2001

Steartrimonium Bromide 1 safe when formulatedto be non- irritating

IJT 31(S3): 296-341(2012)

Steartrimonium Chloride 1 up to o.25% for leave-on products (no rinse-

off uses reported)

IJT 16(S3):195-220,1997; IJT 31(S3):

296-341 (2012)Steartrimonium methosulfate 1 safe when formulated


(2012)Stearyl/Lauryl Methacrylate Crosspolymer 1 safe in the present practices of



Stearyl Acetate 1 0.2 to 0.5% IJT 31(S1):112- 136,2012

Stearyl Alcohol 1 up to 25% JACT 4(5):1-29,1985 confirmed







03/04 IJT 25(S2),2006

Stearyl Beeswax 1 safe for use in cosmetics whenformulated to be non-irritating


Stearyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


from CIRStearyl Benzoate 1 2% IJT 31(3):342-372

(2012)Stearyl betaine 1 concentration not reported* safe for use in cosmetics when


available from CIRStearyl Caprylate 1 0.1 to 1% safe for use in cosmetics when

formulated to be non-irritatingIJT 31(S2): 141-146,


from CIRStearyl citrate 1 0.007 to 12% IJT 33 (S2): 16 -46,

2014Stearyl Dimethicone 1 up to 6% IJT 22(S2):11- 35,

2003Stearyl Erucate 1 not in current use* safe for use in cosmetics when


available from CIRStearyl Ethylhexanoate 1 safe for use in cosmetics when


available from CIRStearyl Glycol 1 not in use at the time* IJT 31 (S2): 147-168,

2012Stearyl Glycyrrhetinate 1 up to 1% IJT 26 (S2):79-112,

2007Stearyl Heptanoate (amended) 1 0.07 to 8% JACT 14(6):497-510,

1995; IJT 31(S2):141-146, 2012;


Stearyl Linoleate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Stearyl Methicone 1 up to 6% IJT 22(S2):11-35,2003

Stearyl Olivate 1 concentration not reported* safe for use in cosmetics whenformulated to be non-irritating


from CIRStearyl Palmitate 1 up to 3% safe for use in cosmetics when

formulated to be non-irritatingIJT 31(S2): 141-146,


from CIRStearyl Phosphate 1 safe for use in cosmetics when


available from CIR







Stearyl Stearate 1 0.02 to 4% safe for use in cosmetics whenformulated to be non-irritating


from CIRSterculia Urens Gum 1 Final report 09/2015

available from CIRStyrene/Acrylates/Ammonium Methacrylate Copolymer 1 safe for use when


2002Styrene/acrylates/dimethicone acrylate crosspolymer 1 not in use at the time* IJT 33 (S2): 65-115,

2014Styrene/acrylates/ethylhexyl acrylate/lauryl acrylatecopolymer


Styrene/Acrylates Copolymer 1 IJT 21(S3):1-50,2002; Final report09/2014 available

from CIRStyrene/butadiene copolymer 1 Final report 09/2014

available from CIRStyrene/isoprene copolymer 1 not in current use* Final report 09/2014

available from CIRStyrene/methylstyrene copolymer 1 not in current use* Final report 09/2014

available from CIRStyrene/stearyl methacrylate crosspolymer 1 not in current use* Final report 09/2014

available from CIRStyrene/va copolymer 1 not in current use* Final report 09/2014

available from CIRStyrene/vp copolymer 1 Final report 09/2014

available from CIRSuccinic Acid 1 up to 0.2% in leave-on;

up to 26% in rinse- offIJT 31 (S1):5-76,

2012Sucralose 1 Final report 03/2014

available from CIRSucrose 1 Final report 03/2014

available from CIRSunfloweramide MEA 1 safe in the present practices



IJT 34(S1): 18-34,2015

Sunflower Seed Acid 1 not in use at the time* Final report 03/11available from CIR

Sunflowerseedamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to be non-

sensitizing, which may








be based on a quantitativerisk assessment (QRA)

Sunflower seed oil PEG-32 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Sunflower seed oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Sweet Almond Amino Acids 1 not in current use* IJT 33(S4):5-12,2014

Sweet almond oil PEG-8 esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Synthetic Beeswax 1 up to 18% JACT 3(3):43-99,1984 confirmed

06/03 IJT24(S1):67-74, 2005

Synthetic Fluorphlogopite 1 0.00002-67% Final report 06/12available from CIR

Synthetic Jojoba Oil (amended) 1 up to 0.1% Amended FinalReport 09/08 -

available from CIRSynthetic Wax 1 up to 29% JACT 3(3):43-99,


24(S1):67-74, 2005Talc 1 IJT 34(S1):66-129,

2015Tallamide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013

Tallamidopropyl Dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Tall Oil Acid (amended) 1 up to 8% IJT 28 (S3):252-258,2009 JACT


Tall oil sterol 1 Final report 12/2013available from CIR

Tallow 1 greater than 50% JACT 9(2):153-64,1990 confirmed

06/06







Tallowamide DEA 1 safe in the present practices ofuse and concentration when



IJT 32(S1):36-58,2013

Tallowamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015

Tallowamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Tallowamidopropyl dimethylamine 1 not in current use* safe for use in cosmeticswhen formulated to benon-sensitizing, which



Tallow Betaine 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Talloweth-18 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Tallow Glyceride 1 up to 25% JACT 9(2):153-64,1990 confirmed

06/06







Tallow Glycerides 1 JACT 9(2):153-64,1990 confirmed

06/06Tallowtrimonium chloride 1 IJT 31(S3): 296-341

(2012)Tamarindus Indica Seed Gum 1 Final report 09/2015

available from CIRTapioca Starch 1 Final report 09/2015

available from CIRTapioca Starch Crosspolymer 1 Final report 09/2015

available from CIRTBHQ (originally t-Butyl Hydroquinone) (Amended) 1 safe up to 0.1% JACT 10(1):1-7,

1991 JACT5(5):329-51, 1986

(Original report)t-Butyl Acetate 1 up to 10% IJT 31(S1):112-136,

2012t-Butyl Alcohol (Amended) 1 up to 0.5% IJT 24 (2):1-20, 2005

(Amended) JACT8(4):627-41, 1989(Original Report)

t-Butyl Hydroquinone (now TBHQ) (Amended) 1 0.1% JACT 10(1):1-7,1991 JACT

5(5):329-51, 1986(Original report)

t-Butyl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

TEA-Alginate 1 Final report 09/2015available from CIR

TEA-C10-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not

exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr

IJT 32(S1): 59-81,2013

TEA-C11-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of free

IJT 32(S1): 59-81,2013







diethanolamine do notexceed the present practices

of use and concentrationof diethanolamine itself.The ingredients shouldnot be used in cosmeticproducts in which N-nitr

TEA-C11-15 Pareth Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013



IJT 32(S1): 59-81,2013

TEA-C12-13 Pareth-3 Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013



IJT 32(S1): 59-81,2013

TEA-C12-15 Alkyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating and

IJT 32(S1): 59-81,2013







when the levels of freediethanolamine do not


TEA-Canolate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Cocoate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Coco-Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-cocoyl alaninate 1 safe for use in cosmetics whenformulated to be non-irritating


TEA-cocoyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating


TEA-cocoyl glutaminate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


TEA-Cocoyl-Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)


11/02 IJT 24(S1):82-85, 2005







TEA-Dextrin Octenylsuccinate 1 Final report 09/2015available from CIR

TEA-Dodecylbenzenesulfonate (amended) 1 up to 5% JACT 12(3):279-309,1993 (original

report); IJT 29 (S4)288-305, 2010

TEA-EDTA 1 not in current use* IJT 21(S2):95- 142,2002

TEA-Glyceryl Dimaleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Hydrochloride 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Hydrogenated Cocoate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-hydrogenated tallowoyl glutamate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


TEA-Isostearate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not

exceed the present practicesof use and concentrationof diethanolamine itself.The ingredients should

IJT 32(S1): 59-81,2013







not be used in cosmeticproducts in which N-nitr

TEA-Lactate 1 when used as an AHAingredient, safe for use atconcentrations less thanor equal to10%, at finalformulation pH greater


sun sensitivity or whendirections for use include thedaily use of sun protection.

These ingredients are safe for

IJT 17(S1):1-242,1998; IJT 32(S1):

59-81, 2013

TEA-Laurate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Laurate/Myristate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Laureth Sulfate 1 safe as used when formulatedto be non- irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-lauroyl/myristoyl aspartate* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


TEA-lauroyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating


TEA-lauroyl glutamate 1 safe for use in cosmetics whenformulated to be non-irritating








TEA-lauroyl keratin amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


TEA-Lauryl Sulfate 1 safe up to 10.5% JACT 1 (4):143-67,1982; IJT 32(S1):

59-81, 2013TEA-Myristate 1 safe as used when formulated

to be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Oleate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Oleyl Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Palmitate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-PEG-3 Cocamide Sulfate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not

IJT 32(S1): 59-81,2013








TEA-Salicylate 1 safe when formulated toavoid irritation and to avoidincreasing sun sensitivity,


IJT 22(3):1-108

TEA Sorbate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA Stearate 1 safe for use in rinse-offproducts; but 15% in leave-

on products; and should not beused with N-nitrosating agents

JACT 14(3): 240-8,1995; IJT 32(S1):

59-81, 2013

TEA Sulfate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Tallate 1 safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

TEA-Tridecylbenzenesulfonate (amended) 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 29 (S4) 288-305,2010







TEA-Undecylenate 1 not in current use* safe as used when formulatedto be non-irritating andwhen the levels of freediethanolamine do not


IJT 32(S1): 59-81,2013

Tetradecyleicosyl Stearate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Tetradecyloctadecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Tetradecyloctadecyl Hexyldecanoate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Tetradecyloctadecyl Myristate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

IJT29(S3) :162-186,2010;


Tetradecyloctadecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating


Tetradecylpropionates 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Tetrahydrofurfuryl Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided;products should beaccompanied with directions


IJT 24(S5):53-100,2005

Tetrasodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002

Theobroma Cacao (Cocoa) Seed Butter 1 0.000002 to 37% Final report 03/11available from CIR

Theobroma Grandiflorum Seed Butter 1 0.00005 to 7% Final report 03/11available from CIR

Thiodipropionic Acid (amended) 1 safe for use in cosmeticformulations when formulated


IJT 29 (S3): 137-150,2010

Thioglycolic Acid (amended) 1 safe for use in hairstraighteners permanentwaves, tonics, dressings,and so forth, wave sets,other noncoloring hair

products, and hair dyes andcolors, at concentrationsup to 15.2%; hairdressers

JACT 10(1):135-92,1991 (original

report); IJT28(S3):68-133, 2009







should avoid skin contactand minimize consumer skin

Threonine 1 0.00002 to 0.05% IJT 32(S4):41-64,2013

Thymol (amended) 1 up to 0.5% IJT 25(S1):29-127,2006

Tin(IV) Oxide 1 0.000003 to 1.3% IJT 33(S4):40-46,2014

Tocopherol 1 less than or equal to 5% IJT 21 (S3):51-116,2002; Final report03/2014 available

from CIRTocophersolan 1 less than or equal to 0.2% IJT 21(S3):51-116,


from CIRTocopheryl Acetate 1 less than or equal to 36%

(100% in Vitamin E oil)IJT 21(S3):51-116,2002; Final report03/2014 available

from CIRTocopheryl Linoleate 1 less than or equal to 2% IJT 21(S3):51- 116,


from CIRTocopheryl Linoleate/Oleate 1 not in current use* IJT 21(S3):51-116,


from CIRTocopheryl Nicotinate 1 less than or equal to 1% IJT 21(S3):51 -116,


from CIRTocopheryl Phosphate 1 not in current use* Final report 03/2014

available from CIRTocopheryl Succinate 1 concentration not reported* IJT 21(S3):51-116,


from CIRTocotrienols 1 Final report 03/2014

available from CIRToluene 1 up to 50% in nail

care productsJACT 6(1):77-120,


2006Toluene-2,5-Diamine (amended) 1 up to 3% JACT 11(4):423-45,

1992 (originalreport); IJT

29(S2):61-83, 2010







Toluene-2,5-Diamine Sulfate (amended) 1 up to 4% JACT 11(4):423-45,1992 (original

report); IJT29(S2):61-83, 2010

Toluene-3,4-Diamine (amended) 1 JACT 11(4):423-45,1992 (original

report); IJT29(S2):61-83, 2010

Toluenesulfonamide/Formaldehyde Resin (aka Tosylamide/Formaldehyde Resin)


09/04 IJT 25(S2),2006

Toluenesulfonamide/Formaldehyde Resin-80 1 not in current use* JACT 5(5):471-490,1986 confirmed

09/04 IJT 25(S2),2006

Toluene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011

Torreya Nucifera Seed Oil 1 not in use at the time* Final report 03/11available from CIR

Tragacanth (Astragalus Gummifer) Gum 1 up to 3% JACT 6(1):1-22,1987 confirmed

09/04 IJT 25(S2),2006

Trehalose 1 Final report 03/2014available from CIR

Triacetin 1 up to 4% IJT 22(S2):1-10,2003

Triarachidin 1 not in current use* IJT 20 (S4):61-94,2001

Tribehenin 1 up to 6% IJT 20(S4):61-94,2001

Tributyl citrate 1 0.0005 to 9% IJT 33 (S2): 16-46,2014

Tri-C12-13 alkyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014

Tri-C14-15 alkyl citrate 1 0.1 to 5% in leave- on IJT 33 (S2): 16-46,2014

Tricaprin 1 not in current use* IJT 20(S4):61- 94,2001

Tricaprylin 1 concentration not reported* IJT 20(S4):61-94,2001

tricaprylyl/capryl trimellitate* 1 safe when formulatedto be non-irritating


Tricaprylyl citrate 1 0.3 to 27% IJT 33 (S2): 16-46,2014

Tricetyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating








Trichloroethane 1 safe as a solvent, but notin use at the time; EPA has

banned all but essentialuses and FDA has said that

aerosol uses are not essential

IJT 27(S4): 107-138,2008

Triclosan 1 0.04 to 0.3% Final report 12/10available from CIR

Trideceth-10 1 safe for cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Trideceth-2 carboxamide MEA 1 safe in the present practicesof use and concentration(rinse-off products only)when formulated to benon-irritating; should


IJT 34(S1): 18-34,2015



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)









IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Tridecyl Behenate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Tridecyl Cocoate (amended) 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating

IJT 30(S1):5S-16S;Final report 06/13

available from CIRTridecyl Erucate 1 safe for use in cosmetics when


available from CIRTridecyl Ethylhexanoate 1 safe for use in cosmetics when


available from CIRTridecyl Isononanoate 1 9% safe for use in cosmetics when


available from CIRTridecyl Laurate 1 not in current use* safe for use in cosmetics when


available from CIRTridecyl Myristate 1 not in use at the time* safe for use in cosmetics when


29(S3) :162-186,2010;Final report 03/2013

available from CIRTridecyl Neopentanoate 1 safe for use in cosmetics when


available from CIRTridecyl Salicylate 1 safe when formulated to



IJT 22(3):1-108

Tridecyl Stearate 1 safe for use in cosmetics whenformulated to be non-irritating


tridecyl trimellitate 1 safe when formulatedto be non-irritating


Trierucin 1 not in current use* IJT 20(S4):61- 94,2001

Triethanolamine 1 safe for use in rinse-offproducts; but 5% in leave-

on cosmetic products;and should not be used

JACT 2(7):183-235,1983; IJT 32(S1):

59-81, 2013







in products containingN-nitrosating agents

Triethanolamine Cocoyl Hydrolyzed Collagen (formerlyTriethanolamine-Coco-Hydrolyzed Animal Protein)


11/02 IJT 24(S1):82-85, 2005

Triethyl citrate 1 0.0008 to 6% IJT 33 (S2): 16-46,2014

Triethylene Glycol 1 0.0006 to 0.2% Amended FinalReport 06/10 -

available from CIRTriethylene Glycol Dimethacrylate 1 safe in nail enhancement




IJT 24(S5):53-100,2005

Triethylhexanoin (aka Trioctanoin) Triisononanoin 1 concentration not reported* IJT 20(S4):61-94,2001

Triethylhexyl citrate 1 concentration not reported* IJT 33 (S2): 16-46,2014

triethylhexyl trimellitate 1 safe when formulatedto be non-irritating


Trifluoropropyl dimethicone/PEG-10 crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Trifluoropropyl dimethicone/trifluoropropyldivinyldimethicone crosspolymer


Trifluoropropyl dimethicone/vinyl trifluoropropyldimethicone/silsesquioxane crosspolymer


Trifluoropropyldimethyl/trimethylsiloxysilicate 1 safe when formulatedand delivered in the


IJT 31(S1):5-24(2013)

Trigonella foenum-graecum hydroxypropyltrimoniumchloride


Triheptanoin 1 not in current use* IJT 20 (S4):61-94,2001

Triheptylundecanoin 1 not in current use* IJT 20(S4):61-94,2001

Trihexyldecyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014

Trihydroxystearin 1 up to 5% IJT 19(S1):89-94,2000

Triisocetyl citrate 1 0.6to 3% in leave-on IJT 33 (S2): 16-46,2014







triisodecyl trimellitate 1 safe when formulatedto be non-irritating


Triisopalmitin 1 not in current use* IJT 20 (S4):61-94,2001

Triisopropanolamine 1 safe for use in cosmeticproducts; but should not beused in products containing



12/04 IJT 25(S2),2006

Triisopropyl citrate 1 not in current use* IJT 33 (S2): 16-46,2014

Triisostearin 1 less than 40% IJT 20(S4):61- 94,2001

Triisostearyl citrate 1 0.3 to 80% in leave-on, concentration notreported for rinse-off


triisotridecyl trimellitate 1 safe when formulatedto be non-irritating


Trilaurin 1 less than 50% IJT 20(S4):61-94,2001

Trilauryl citrate 1 not in current use* Final report 03/12available from CIR

Trilauryl phosphate 1 not in current use* Final report 09/2014available from CIR

Trilinolein 1 concentration not reported* IJT 20(S4):61-94,2001

Trimethylolpropane Trimethacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Trimethylsiloxysilicate 1 safe when formulatedand delivered in the


IJT 31(S1):5-24(2013)

Trimethylsiloxysilicate/ dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Trimethylsiloxysilicate/dimethiconol crosspolymer 1 up to 2% Final report 12/10available from CIR

Trimyristin 1 concentration not reported* IJT 20(S4):61-94,2001

Trioctyldodecyl citrate 1 1 to 30% in leave- on Final report 03/12available from CIR

Triolein 1 not in current use* IJT 20(S4):61- 94,2001







Trioleyl citrate 1 not in current use* Final report 03/12available from CIR

Trioleyl phosphate 1 safe for use in cosmetics whenformulated to be non-irritating


Tripalmitin 1 concentration not reported* IJT 20(S4):61-94,2001

Tripalmitolein 1 not in current use* IJT 20 (S4):61-94,2001

Tripeptide-1 1 Final report 06/2014available from CIR

Tripotassium EDTA 1 concentration not reported* IJT 21(S2):95-142,2002

Tripropylene Glycol 1 safe when formulatedto be non- irritating

IJT 31(2) 245-260,2012

Triricinolein 1 not in current use* IJT 20 (S4):61-94,2001

Trisodium EDTA 1 less than 1% IJT 21(S2):95- 142,2002

Trisodium Glycyrrhizate 1 not in current use* IJT 26(S2):79-112,2007

Trisodium HEDTA 1 less than 1% IJT 21(S2):95- 142,2002

Tristearin 1 concentration not reported* IJT 20(S4):61-94,2001

Tristearyl citrate 1 not in current use* Final report 03/12available from CIR

Tristearyl phosphate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Triticum Aestivum (Wheat) Germ Oil 1 not in use at the time* Final report 03/11available from CIR

Triticum Vulgare (Wheat) Germ Oil 1 0.0001 to 28% Final amended report03/11 available

from CIR; JEPT4(4):33-45, 1980;

re-review IJT22(S1):1-35, 2003

Triticum Vulgare (Wheat) Germ Oil Unsaponifiables 1 up to 0.2% Final report 03/11available from CIR

Triticum Vulgare (Wheat) Gluten 1 less than or equal to 1% JEPT 4(4):5-17, 1980confirmed 06/01 IJT

22(S1):1-35, 2003Triticum Vulgare (Wheat) Kernel Flour 1 up to 1% JEPT 4(4):19-32,


22(S1):1-35, 2003Triticum Vulgare(Wheat) Starch 1 JEPT 4(4):19-32,








22(S1):1-35, 2003;Final report 09/2015

available from CIRTriundecanoin 1 not in current use* IJT 20 (S4):61-94,

2001Tromethamine 1 Final report 09/2013

available from CIRTryptophan 1 0.00% IJT 32(S4):41-64,

2013Tyrosine 1 0.0005 to 1% IJT 32(S4):41-64,

2013Umbilical Extract 1 if used, should not deliver



IJT 21(S1):81-91,2002

Undeceth-11 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)



IJT 31(S2):169-244(2012)

Undecylenamide DEA 1 safe in the present practices ofuse and concentration when




CIR

Undecylenamide MEA 1 safe in the present practicesof use and concentration

IJT 34(S1): 18-34,2015







(rinse-off products only)when formulated to benon-irritating; should


Undecylenamidopropyl betaine 1 safe for use in cosmeticswhen formulated to benon-sensitizing, which


IJT 31(S1):77-111,2012

Undecyleneth-6 1 safe for use in cosmeticswhen formulated


IJT 31(S2):169-244(2012)

undecylenoyl collagen amino acids 1 safe for use in cosmetics whenformulated to be non-irritating

Final report 12/2013available for CIR

undecylenoyl glycine 1 safe for use in cosmetics whenformulated to be non-irritating


Undecylenoyl Inulin 1 Final report 09/2015available from CIR

undecylenoyl phenylalanine 1 safe for use in cosmetics whenformulated to be non-irritating


undecylenoyl wheat amino acids* 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Undecylenoyl xanthan gum 1 not in current use* Final report 09/12available from CIR

Undecyl glucoside 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 32 (S3): 22-48,2013

Urea 1 up to 10% IJT 24(S3):1-56,2005

Urethane Methacrylate 1 safe in nail enhancementproducts when skin contact isavoided; products containing



IJT 24(S5):53-100,2005

Urocanic Acid 1 JACT 14(5):386-423,1995

VA/Butyl Maleate/Isobornyl Acrylate Copolymer 1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

VA/Crotonates Copolymer (formerly Vinyl Acetate/CrotonicAcid Copolymer)


06/03 IJT 24(S1):101-102, 2005

Vaccinium Corymbosum (Blueberry) Seed Oil 1 not in use at the time* Final report 03/11available from CIR







Vaccinium Macrocarpon (Cranberry) Seed Oil 1 0.002 to 2% Final report 03/11available from CIR

Vaccinium Myrtillus Seed Oil 1 0.01 to 0.1% Final report 03/11available from CIR

Vaccinium Vitis-Idaea Seed Oil 1 concentration not reported* Final report 03/11available from CIR

Valine 1 0.0004 to 1% IJT 32(S4):41-64,2013

Vegetable (Olus) Oil 1 0.0005 to 31% Final report 03/11available from CIR

Vegetable Amino Acids 1 IJT 33(S4):5-12,2014

Vinyl Caprolactam/PVP/ Dimethylaminoethyl MethacrylateCopolymer

1 safe for use whenformulated to avoid irritation

IJT 21(S3):1-50,2002

Vinyl Dimethicone 1 not in current use* IJT 22 (S2):11-35,2003

Vinyl dimethicone/lauryl/behenyl dimethicone crosspolymer 1 not in current use* IJT 33 (S2): 65-115,2014

Vinyl dimethicone/lauryl dimethicone crosspolymer 1 0.09 to 2% IJT 33 (S2): 65-115,2014

Vinyl dimethicone/methicone silsesquioxane crosspolymer 1 0.1 to 20% IJT 33 (S2): 65-115,2014

Vinyldimethyl/trimethylsiloxysilicate/dimethiconecrosspolymer


Vinyldimethyl/trimethylsiloxysilicate stearyl dimethiconecrosspolymer


Vitis Vinifera (Grape) 1 0.10% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) bud extract 1 0.08% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) flower extract 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) fruit extract 1 0.000001 to 2% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) fruit powder 1 concentration not reported* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) fruit water 1 0.7 to 0.8% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) juice 1 0.01 to 2% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) juice extract 1 concentration not reported* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) leaf/seed/skin extract 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) leaf extract 1 0.01 to 3% IJT 33(S3):48-83,2014







Vitis Vinifera (Grape) leaf oil 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) leaf water 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) leaf wax 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) root extract 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) seed 1 0.05 to 0.08% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) seed extract 1 0.00002 to 0.2%l. IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) Seed Oil 1 0.001 to 43% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) Seed powder 1 concentration not reported* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) shoot extract 1 0.00% IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) skin extract 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) skin powder 1 not in current use* IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) vine extract 1 IJT 33(S3):48-83,2014

Vitis Vinifera (Grape) vine sap 1 not in current use* IJT 33(S3):48-83,2014

VP/VA Copolymer 1 up to 12% JACT 2(5):141-59,1983 confirmed

09/03Watermelon seed oil PEG-8 esters 1 safe for use in cosmetics when


2014Welan Gum 1 not in current use* Final report 09/12

available from CIRWheat Amino Acids 1 IJT 33(S4):5-12,

2014Wheat Germ Acid 1 concentration not reported* Final report 03/11

available from CIRWheat germamide DEA 1 safe in the present practices of




IJT 32(S1):36-58,2013

Wheat germamidopropyl betaine 1 safe for use in cosmeticswhen formulated to be

IJT 31(S1):77-111,2012







non-sensitizing, whichmay be based on a

quantitative risk assessmentWheat germamidopropyl dimethylamine 1 not in current use* safe for use in cosmetics

when formulated to benon-sensitizing, which



Wheat Germ Glycerides 1 up to 25% JEPT 4(4):5- 17,1980 confirmed

06/01 IJT22(S1):1-35, 2003

Wheat Germ Oil PEG-40 Butyloctanol Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Wheat Germ Oil PEG-8 Esters 1 safe for use in cosmetics whenformulated to be non-irritating

IJT 33(S4):13-39,2014

Wild Yam (Dioscorea Villosa) Root Extract 1 up to 15% of max2% plant solids

IJT 23(S2):49-54,2004

Xanthan Gum 1 0.00001 to 6% Final report 09/12available from CIR

Xanthan Gum Crosspolymer 1 0.03 to 5% Final report 09/12available from CIR

Xanthan Hydroxypropyltrimonium chloride 1 not in current use* Final report 09/12available from CIR

Xylene Sulfonic Acid 1 not in current use* IJT 30(S3):270-283,2011

Xylobiose 1 Final report 03/2014available from CIR

Xyloglucan 1 Final report 09/2015available from CIR

Xylose 1 Final report 03/2014available from CIR

Yeast amino acids 1 not in current use* IJT 33(S4):5-12,2014

Zea Mays (Corn) Cob Meal 1 up to 3% IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Cob Powder 1 up to 10% IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Fruit 1 not in current use* IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Germ Extract 1 concentration not reported* IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Germ Oil 1 0.2 to 25% Final amended report03/11 available

from CIR; IJT 30(S1): 17-39, 2011

(original)







Zea Mays (Corn) Gluten Protein 1 0.03 to 0.1% IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Kernel Extract 1 up to 0.5% IJT 30 (S1): 17-39,2011

Zea Mays (Corn) Kernel Meal 1 up to 3% Final amended report03/11 available

from CIR; IJT 30(S1): 17-39, 2011

(original)Zea Mays (Corn) Oil 1 up to 14% Final amended report

03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011

(original)Zea Mays (Corn) Oil Unsaponifiables 1 concentration not reported* Final amended report

03/11 availablefrom CIR; IJT 30(S1): 17-39, 2011

(original)Zea Mays (Corn) Seed Flour 1 concentration not reported* IJT 30 (S1): 17-39,

2011Zea Mays (Corn) Silk Extract 1 up to 0.1% IJT 30 (S1): 17-39,

2011Zea Mays (Corn) Starch 1 up to 99% IJT 30 (S1): 17-39,

2011Zeolite 1 not in current use* IJT 22(S1):37- 102,

2003Zinc Acetate 1 concentration not reported* IJT 31(S1):112-136,

2012Zinc borosilicate 1 not in current use* IJT 32(S3): 65-72,

2013Zinc citrate 1 0.05% in leave-on;

0.3 to 2% in rinse-offIJT 33 (S2): 16-46,

2014Zinc Coceth Sulfate 1 safe in the present practices of


IJT29(S3) :151-161,2010

Zinc Coco-Sulfate 1 not in current use* IJT 29(S2): 115-132,2010

Zinc lauroyl aspartate 1 not in current use* safe for use in cosmetics whenformulated to be non-irritating


Zinc Myristate 1 up to 20% IJT29(S3) :162-186,2010

Zinc Phenolsulfonate 1 up to 4% JACT 5(5):373-90,1986 confirmed

06/04 IJT 25(S2),2006

Zinc Ricinoleate 1 up to 2% IJT 26(S3): 31-772007







Zinc Stearate 1 up to 51% JACT 1(2):143-77,1982 confirmed

11/01 IJT22(S1):1-35, 2003

Zirconium Silicate 1 not in current use * IJT 22(S1):37-102,2003

† Please consider the most recent findings only. Previous citations are only offered for reference purposes.* Were the ingredient to be used in the future, the expectation is that it would be used at concentrations comparable to others in the group.** Safety as a hair dye ingredient was reaffirmed in 2004; but the Panel noted that the use of p-Phenylenediamine with henna (so-called dark henna) for temporary tattoos is unapproved by FDA — p-Phenylenediamine is a knownsensitizer, highly inappropriate for such use as evidenced by reports of severe adverse skin reactions to dark henna temporary tattoos.*** in addition, "red" panax ginseng root extract and "white" panax ginseng root extract are reported to be used, within the given concentration range, but they are not separately listed as cosmetic ingredients**** S - safe in the present practices of use and concentration SQ - safe for use in cosmetics, with qualifications I - the available data are insufficient to support safety Z - the available data are insufficient to support safety, but theingredient is not in current use U - the ingredient is unsafe for use in cosmetics UNS - ingredients for which the data are insufficient and their use in cosmetics is not supported Note: the number given is the number of ingredientsin the given category in that row

Documents

Quick Reference Table Conclusion**** Citation † …...2-Chloro-p-Phenylenediamine Sulfate 1 up to 1.0% JACT 11(4):521-530, 1992 2-Ethoxy Ethoxy Ethyl Methacrylate 1 safe in nail