QUALITY ANALYSIS STARTS WITH BEGINS WITH ... - Milestone Inc. · microwave hardware, user interface, reaction sensor technology and pressure resistant vessels. The ETHOS UP is the

GREAT SAMPLE PREPARATIONBEGINS WITHBEST ELEMENTAL ANALYSIS

MILESTONEH E L P I N GC H E M I S T S

ETHOS UPHigh Performance

Microwave Digestion System

GREAT SAMPLE PREPSTARTS WITHQUALITY ANALYSIS

It is a common misconception that all laboratory microwave systems are alike; at Milestone we know this is not true. Sample preparation is one of the most impactful steps in trace metals determination. The quality of analytical data obtained by ICP/ICP-MS is directly reliant on digestion quality. Today, microwave technology in sample preparation has been established in a variety of industries: Environmental, Food, Pharmaceutical, Agriculture, Consumer Product Testing, Specialty Chemicals, Geological, Mining, and many others. Milestone’s sample preparation solutions maximize the AA/ ICP/ ICP-MS/ performance, and a lab's overall analytical capability.

Choosing the right system and configuration is a key step in maximizing investment and expanding your lab’s capabilities. Some of the most crucial parameters that should be considered when choosing a microwave digestion system include the following:

R E S U LT ST H E F I R S T S T E PT O C O N F I D E N T

LAB THROUGHPUT

SIMPLICITY AND EASE OF USE

RELIABILITY

FLEXIBILITY

SAMPLE TYPE

EXPERTISEAND KNOW-HOW

SUPERIOR SAFETYAND RELIABILITY

UNRIVALED PERFORMANCEAND THROUGHPUT

ULTIMATE EASE OF USEAND CONTROL

FLEXIBILITY

FOCUS ON WHAT MATTERS: YOUR APPLICATION

The ETHOS UP fully embodies Milestone’s philosophy towards, and knowledge of, microwave sample preparation. Specifically designed for closed vessel acid digestion, it offers a perfect integration of microwave hardware, user interface, reaction sensor technology and pressure resistant vessels. The ETHOS UP is the most powerful system in the market, with two magnetrons and a total power of 1900 Watts. Microwave homogeneity is assured through a dedicated microwave diffuser. Safety and reliability are Milestone’s priorities. Both factors are ever present in the foundation of the ETHOS UP’s design. The cavity has a volume in excess of 70L, and is constructed entirely of stainless steel to ensure longevity and structural integrity. Our unique pressure responsive door, also made of stainless steel, ensures superior safety even with the most reactive samples. The safeVIEW high definition digital camera, allows to safely look into the microwave cavity.

SAFETY AND RELIABILITY IN SAMPLE PREPARATION

In a digestion process the temperature controls the sample decomposition and directly affects digestion quality. Milestone pioneered the use of infrared sensors combined with an in-situ temperature sensor to more accurately control the digestion cycle. Today, Milestone innovates again by combining all the benefits of in-situ and infrared sensors into a single solution: the Milestone easyTEMP, a direct contactless temperature sensor.

EASEOF USE

DIRECTCONTROL

PRECISION AND ACCURACY

CONTROL INALL VESSELS

SAFETY

RUN ANY NUMBEROF VESSELS

MILESTONE easyTEMP

DIGESTION CONTROL

EASE OF USEWITH UNPARALLELED

INFRARED APPROACHIN-SITU APPROACH

ENHANCED CONTROL IN ALL VESSELS

FAST, ACCURATE AND TRACEABLE

SUPERIOR DIGESTION QUALITY

LOWER RUNNING COSTS

INCREASED EASE OF USE AND PRODUCTIVITY

The easyTEMP contactless sensor directly controls the temperature of all samples and solutions, providing accurate temperature feedback to ensure complete digestion in all vessels with superior safety. This technology combines the fast and accurate reading of an in-situ temperature sensor with the flexibility of an infrared sensor. The ETHOS UP software provides digestion history traceability and temperature measurement for every sample. Temperature diagrams and profiles are displayed in real-time, and can be saved on the ETHOS UP terminal.

easyTEMP temperature control of an exothermic reaction

during the digestion of an API with HNO3 and HCl

in the SK-15 rotor

This rotor diagram represents the digestion temperature

in all vessels. The green color indicates if the vessel has

achieved the set conditions

Temperature profile of a soil digestion in accordance

with US EPA 3051 using the MAXI-44 rotor

IN ALL VESSELS

e a s y T E M PDIRECT CONTACTLESSTEMPERATURE SENSOR

M I L E S T O N EH E L P I N GC H E M I S T S

www.milestonesrl.com

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THAT MAKE THE

D I F F E R E N C E

FLEX IB ILTY ANDP E R F O R M A N C E

Regardless of the samples you’re trying to digest, the Milestone SK-15 rotor is always an effective option to simplify your journey from sample to analysis, even with hard-to-digest samples. The SK-15 is a high-pressure and high-temperature rotor with a capacity of up to 15 PTFE vessels of 100 mL suitable for digestion of polymers, large food and feed samples, pharmaceuticals, alloys and geological materials. The table shows the recovery study with the SK-15 on pharmaceutical samples. The simplified design of the rotor coupled with its large vessel capacity ensures high productivity without compromising on performance. Safety is assured by our unique vent-and-reseal technology, the foundation of Milestone’s position as the leader in closed vessel microwave digestion. Milestone has recently evolved this already advanced technology (US Patent 5,270,010), providing the operator with unsurpassed safety and performance capabilities by further increasing the temperature and pressure capacities of the vessels.

Sample As Cd Pb Hg

Spike value (mg/L) 15 2 5 3

CapsulesRecovery % (n=3)

91.1 92.3 102.3 97.6

CapsulesRSD (%)

1.4 1.4 1.4 0.3

Dietary SupplementRecovery % (n=3)

100.2 95.4 95.2 97.5

Dietary SupplementRSD (%)

0.6 1.6 1.3 1.5

SK-15 ROTOR

A safety spring built into the cover allows for precise venting of the vessel, if that should occur. Once the pressure has been reduced to a containable level, the cover closes again. Only the excess pressure, mainly generated by CO2, NOX fumes, is therefore released, allowing for a complete recovery of even volatile elements.

Scheme of the Vent-And-Reseal technology

L A B O R AT O R I E S

THE IDEAL TOOL FOR

HIGH PRODUCTIVITY

Many laboratories need to increase productivity and reduce the turn-around-time in metals analyses. The MAXI-44 perfectly matches these needs, providing high productivity, reliability and superior ease of use. The MAXI-44 is a high-throughput rotor featuring up to 44 PTFE vessels of 100 ml suitable for a wide range of samples, such as environmental, agriculture, food, and feed. The MAXI-44 is perfect for routine applications, combining an unmatched ease of use with the highest sample throughput available on the market today. The table shows the recovery study with MAXI-44 on Lake sediment BCR280R.

SampleCertified value

(mg/Kg)Recovery %

(n=3)RSD (%)

As 33.4 ± 2.9 98.4 2.1

Co 16.8 ± 0.9 91.3 2.4Cr 126 ± 7 95.2 2.0Cu 53 ± 6 90.3 1.7

Zn 224 ± 25 93.4 2.1

SK-15 APPLICATIONS

MAXI-44 ROTOR

MAXI-44 APPLICATIONS

Agriculture Agriculture

Cosmetics

Petrochemical

Beverage Beverage

Environmental

Environmental

Officials

Officials

Ceramics

Food & Feed Food & Feed

Pharmaceutical

Pharmaceutical

Chemicals

Geochemistry

Pigments

Clinical

Metals

Polymers

TO SAVEYOUR TIME

SMART SOFTWARE

The ETHOS UP comes with a dedicated touch screen terminal with easyCONTROL software which incorporates our expertise and knowledge in microwave sample preparation. The ETHOS UP user-interface provides full control of all digestion parameters, complete documentation and improves the overall procedure. The terminal is equipped with multiple USB and Ethernet ports for interfacing the instrument to external devices and to the laboratory network.The ETHOS UP controller is user-friendly, icon-driven, multi-language and 21 CFR Part 11 compliant. To find the method which best suits your application, simply select one of the hundreds of preloaded methods or create a

new one yourself using our intuitive software. Once you press ‘START’ the system will automatically follow the user defined temperature profile using a sophisticated PID algorithm. The preloaded applications, including all US EPA methods, virtually eliminate any need for method development. Each preloaded method includes a temperature profile, sample size and choice of reagents. To further simplify the workflow in the lab the ETHOS UP is equipped with a backlit logo that indicates the digestion progress, showing to the operator the actual status of the process, such as heating, cooling, sample ready and error messages.

Included with the ETHOS UP is a unique web-based application: Milestone Connect. This app allows you to become a part of the Milestone community and gain exclusive access to a robust library of information: lists of parts, technical notes, user manuals, video tutorials, continuously updated application notes and all relevant scientific articles. Milestone Connect also extends instrument control to your smartphone, tablet or PC, allowing remote monitoring of the system. With Milestone Connect you have instant support 24/7.

milestonennect

30 YEARS OF EXPERIENCE

MILESTONEC O N N E C TAT YOUR FINGERTIPS



Food & Feed

Baby FoodBarleyBeech LeavesBovine LiverBovine MilkButterCalcium AlginateCaseinChcolateCocoa PowderCofeeCorn StarchDried FishDried MeatDry Infant FormulaDeed for FishFish in OilFresh Meat

MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44





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Parameter "USEPA 3051 Soil, sediments, sludges and oils"Exhaust : 15 min ñññP2-Check : not presentStirrer : not presentTwist : OffRotor control : OnStart-Parameter : Current valuesControl for : T1System : Ethos 1Rotor : SKType of vessels :Number of vessels : 0Cooling system :Operating mode : MW cont.

MW program "USEPA 3051 Soil, sediments, sludges and oils"Nr t T1 T2 P E Vent.1 00:10:00 175°C 1000W ñññ2 00:05:00 175°C 1000W ñññ

Remarks0,5g of sample 10ml of HNO3 or 9ml of HNO3 and 3ml of HCl

Created from "Administrator"27.03.2014 09:15:20"test sk15-sludgeCRM.dpr"

28.02.1728.02.1728.02.1728.02.1728.02.1728.02.1701.03.1701.03.1701.03.1701.03.1701.03.1701.03.1701.03.17

14:21:0114:21:1115:10:3415:26:1916:26:2416:44:0408:52:2208:52:2908:53:3209:43:4709:58:2409:59:3410:01:21

Seg6=00:02:00/1000W7210°C/0°C/30.0bar/0/0/3Start: P TestP test_20170228_14211.dpr: saved to: A/Data/P Test_Start: Milk powder_tests elastomerProgram �nishedMilk powder_test elastomer_20170228_152619.dpr:Login Admin (Administrator)test for thermo_mat.fat: File read error.Start: Milk powder_test elastomerMilk powder_test elastomer_20170301_085332.dpr:Login Admin(Administrator)New Method from database: P Test Digestion AgricolLogin (Service)

TerminalPanel

All System Access Errors ApplicationUsers Update LAN Trail

Settings Service

Filter

Time Changes

Usage



Food & Feed

Baby FoodBarleyBeech LeavesBovine LiverBovine MilkButterCalcium AlginateCaseinChcolateCocoa PowderCofeeCorn StarchDried FishDried MeatDry Infant FormulaDeed for FishFish in OilFresh Meat

MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44MAXI-44





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Parameter "USEPA 3051 Soil, sediments, sludges and oils"Exhaust : 15 min ñññP2-Check : not presentStirrer : not presentTwist : OffRotor control : OnStart-Parameter : Current valuesControl for : T1System : Ethos 1Rotor : SKType of vessels :Number of vessels : 0Cooling system :Operating mode : MW cont.

MW program "USEPA 3051 Soil, sediments, sludges and oils"Nr t T1 T2 P E Vent.1 00:10:00 175°C 1000W ñññ2 00:05:00 175°C 1000W ñññ

Remarks0,5g of sample 10ml of HNO3 or 9ml of HNO3 and 3ml of HCl

Created from "Administrator"27.03.2014 09:15:20"test sk15-sludgeCRM.dpr"

28.02.1728.02.1728.02.1728.02.1728.02.1728.02.1701.03.1701.03.1701.03.1701.03.1701.03.1701.03.1701.03.17

14:21:0114:21:1115:10:3415:26:1916:26:2416:44:0408:52:2208:52:2908:53:3209:43:4709:58:2409:59:3410:01:21

Seg6=00:02:00/1000W7210°C/0°C/30.0bar/0/0/3Start: P TestP test_20170228_14211.dpr: saved to: A/Data/P Test_Start: Milk powder_tests elastomerProgram �nishedMilk powder_test elastomer_20170228_152619.dpr:Login Admin (Administrator)test for thermo_mat.fat: File read error.Start: Milk powder_test elastomerMilk powder_test elastomer_20170301_085332.dpr:Login Admin(Administrator)New Method from database: P Test Digestion AgricolLogin (Service)

TerminalPanel

All System Access Errors ApplicationUsers Update LAN Trail

Settings Service

Filter

Time Changes

Usage

List of food & feed methods, part of the expansive

library containing over 300 built-in methods

Audit trail tacking in full compliance

with 21 CFR part 11

The ETHOS UP embraces Milestone’s philosophy of a “microwave labstation”. The ETHOS UP platform is capable of several applications beyond microwave digestion. Extraction of pollutants from environmental samples can be done in just few minutes, consuming less solvent than other technologies, thereby improving productivity while decreasing costs, all in full accordance with the US EPA 3546. Additional

Milestone fastEX-24 recovery study and comparison vs Soxhlet for various organic compounds.

High-pressure digestion rotorExtraction rotor for environmental applications

Extraction rotor for total fat determination in food samples

THAN A DIGESTION SYSTEM

MILESTONE ETHOS UP

MUCH MORE

fastEX-24 SK-10/12

SR-12

PAHsPCBs

100%

TPH Dioxins BNAsOrganicsemivolatiles

Soxhlet fastEX-24

Compliance with regulations and data traceability requirements are paramount in the modern analytical lab, such as pharmaceutical, nutraceutical or other regulated industries. Milestone’s operating software, easyCONTROL, is fully compliant with FDA regulation 21 CFR part 11. The Milestone Validation Package gives access to our factory trained engineers and specialists during the qualification process, enabling a fast implementation of the ETHOS UP in full accordance with Good Manufacturing Practice (GMP) guidelines. The comprehensive Milestone Validation Package (MVP) assures the complete qualification of the instrumentation. Different validation packages are available based on your specific needs: DQ (Design Qualification), IQ (Installation Qualification), OQ (Operational Qualification), PQ (Performance Qualification) and re-qualification.

High-temperature muffle furnace(up to 1200°C)

Evaporation/Concentration rotor

P A C K A G E

MEET ING REGULAT IONS :M I L E S T O N E ' SVAL IDAT ION

accessories are available to further expand the ETHOS UP capabilities: additional digestion rotors, inserts and micro-inserts to reduce blanks in the digestion processes, a dedicated configuration for total fat determination in food samples which greatly improves turn-around-time, and an ashing accessory which converts the digestion system into a microwave muffle.

ultraFAST

MMR-15

duoPUR/subCLEANultraWAVE

Acid PurificationSystem

The Game Changer in Microwave Digestion

Acid SteamCleaning System

Direct Mercury Analyzer

traceCLEAN DMA-80

Established in 1988, Milestone is headquartered in Italy and has offices in Germany, Switzerland, the Unites States, China,Japan and Korea. We operate worldwide through a network

of over 100 exclusive distributors, all providing our customers premium application and service support. Milestone’s mission is to help chemists by offering them the most advanced instrumentation for sample preparation and direct mercury analysis in the world. Our industry-leading technology, in combination with fast, responsive service and applications support, allows Milestone to support our goal of providing you the highest return on investment possible.

MILESTONEHELPING CHEMISTS

H E L P I N GC H E M I S T S

MILESTONE MILESTONE INC. - 25 Controls Drive - Shelton, CT 06484 - USATel: (203) 925-4240 - Toll-free: (866) 995-5100 - Fax: (203) 925-4241www.milestonesci.com - email: [email protected]

MILESTONE Srl - Via Fatebenefratelli, 1/5 - 24010 Sorisole (BG) - ItalyTel: +39 035 573857 - Fax: +39 035 575498www.milestonesrl.com - email: [email protected]

MILESTONE GENERAL K.K. - KSP, 3-2-1, Sakado - Takatsu-Ku,Kawasaki 213-0012 - Japan - Tel: +81 (0)44 850 3811 - Fax: +81 (0)44 819 3036 www.milestone-general.com - email: [email protected]

MLS GmbH - Auenweg 37 D-88299 Leutkirch im Allgau - GermanyTel: +49 (0)7561 9818-0 - Fax: +49 (0)7561 9818-12www.mls-mikrowellen.de - email: [email protected]

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ADDITIONAL MILESTONE SOLUTIONS FOR ELEMENTAL ANALYSIS

Documents

QUALITY ANALYSIS STARTS WITH BEGINS WITH ... - Milestone Inc. · microwave hardware, user interface, reaction sensor technology and pressure resistant vessels. The ETHOS UP is the