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Shengwen Calvin Li, PhD

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Page 1 of 3Shengwen Calvin Li, PhD Quantitative Imaging in Medicine and Surgery

11/14/2016http://qims.amegroups.com/user/view/113966

NeuroOncology and Stem Cell Research Laboratory, Center for Neuroscience Research, CHOC Children's Hospital, University of California Irvine School of Medicine, Orange, CA, USA

Dr. Li has 148+ publications including the peerreviewed research articles, reviews, book chapters, and patent applications. His publications have been remarked in articles published in Nature, Science, Cell, and Annual Reviews of Cell and Developmental Biology, with total citations of 7,000+. His publication was on top 50 mostfrequentlycited Journal of Biological Chemistry (JBC) Articles (#49) in 2004; on top 40 in 2005 and 2006, respectively. His recent research was highlighted on the cover of August 2011 issue of Proceedings of the National Academy of Sciences of USA. His publications identify CaveolinScaffolding Domain (CSD) and CSDinteracting motif (CIM), spring up research on caveolinmediated signaling and related diseases – both terms are well adopted in literature and textbooks. His research helps lead to $2.9 billion agreement for targeting a previously unrecognized tumoractivated, albuminspecific biologic pathway with a nanoshell of the human blood protein albumin in 2011. This nanoshuttle system is believed to activate an albuminspecific (Gp60) receptormediated transcytosis path through the cell wall of proliferating tumor cells, using caveolin1 activated caveolar transport. He led to complete sequencing of whole genome for Botulinum neurotoxin Type AHall (Allergan BOTOX®) Strain, from which BOTOX® branded therapeutic products are manufactured with annual sale of $1.3 billion. He publication “A biological global positioning system (GPS): considerations for tracking stem cell behaviors in the whole body” was on feature story: Commented by Jeffrey M. Perkel, Ph.D., in BioTechniques Focus: Translational Tools – Special News Feature entitled “What lies beneath: In vivo stem cell imaging,” BioTechniques. He published a concept “therapeutic window” as a tool for personalized treatment of cancer.

He has been a member of Association for Clinical and Translational Science (ACTS), Society for Translational and Clinical Sciences, International Society of Stem Cell Research (ISSCR), Society for Neuroscience (SfN), American Society for Cell Biology (ASCB), American Association for the Advancement of Science (AAAS), American Society for Neurochemistry (ASN), and American Society of Investigative Pathology (ASIP).

He has served on the editorial board of American Journal of Pathology ((Official Journal of ASIP) since 2008, on the editorial board (section editor) of the Journal of Stem Cell & Therapy since 2011, on the editorial board of the World Journal of Stem Cells since 2012, the editorial board of the MOJ Cell Science & Reports since 2014, the editorial board of for the journal Current Stem Cell Research & Therapy (Bentham Science Publishers) since 2015. He has also served on an adhoc reviewer for many other journals and grant agencies.

Research Interest

Pediatric brain tumor biology, stem cell differentiation mechanisms, stem cellbased therapy, engineered tissue graft, engineerdesign matrix for cell and organ culture, Caveolinmediated signal transduction, immunotherapy of cancer, realtime imaging for tumor progression and stem cell development, precision medicine.

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Quantitative Imaging in Medicine and Surgery (Print ISSN 22234292; Online ISSN 22234306; QIMS) publishes

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