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Wednesday, 26 September 2013 7 th CGO Workshop @ Berder Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality Control V. Reithinger 1 , J. Baudot 2 , S. Brons 3 , D. Dauvergne 1 , G. Dedes 1 , J. Krimmer 1 , C. La Tessa 4 , K. Parodi 5,6 A.-L. Pequegnot 1 , R. Pleskac 4 , C. Ray 1 , I. Rinaldi 5 , M. De Rydt 7 , E. Testa 1 , M. Vanstalle 4 1 Université Lyon 1 and CNRS/IN2P3/Institut de Physique Nucléaire de Lyon, UMR 5822, F-69622 Villeurbanne, France 2 Université Louis Pasteur and CNRS/IN2P3/IPHC , F-67037 Strasbourg, France 3 Heidelberg Ion Beam Therapy center (HIT), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany 4 GSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, D-64291 Darmstadt, Germany 5 University Clinic Heidelberg, Dep. Radiation Therapy and Radiation Oncology, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany 6 Ludwig Maximilians University (LMU) Munich, Am Coulombwall 1, 85748 Garching, Germany 7 Instituut voor Kern- en Stralingsfysica, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven, Belgium

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Page 1: Proton Interaction Vertex Imaging With Silicon-Pixel CMOS ...CGO ws V. Reithinger – Proton Interaction Vertex Imaging for carbon therapy quality control 3 Proton Interaction Vertex

Wednesday, 26 September 20137th CGO Workshop @ Berder

Proton Interaction Vertex Imaging With Silicon-Pixel CMOS Telescope For Carbon Therapy Quality Control

V. Reithinger1, J. Baudot2, S. Brons3, D. Dauvergne1, G. Dedes1, J. Krimmer1, C. La Tessa4, K. Parodi5,6

A.-L. Pequegnot1, R. Pleskac4, C. Ray1, I. Rinaldi5, M. De Rydt7, E. Testa1, M. Vanstalle4

1 Université Lyon 1 and CNRS/IN2P3/Institut de Physique Nucléaire de Lyon, UMR 5822, F-69622 Villeurbanne, France 2 Université Louis Pasteur and CNRS/IN2P3/IPHC , F-67037 Strasbourg, France

3 Heidelberg Ion Beam Therapy center (HIT), Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany4 GSI Helmholtzzentrum für Schwerionenforschung GmbH, Biophysics Division, D-64291 Darmstadt, Germany

5 University Clinic Heidelberg, Dep. Radiation Therapy and Radiation Oncology, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany6 Ludwig Maximilians University (LMU) Munich, Am Coulombwall 1, 85748 Garching, Germany

7 Instituut voor Kern- en Stralingsfysica, KU Leuven, Celestijnenlaan 200D, B-3001 Leuven, Belgium

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▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives

▸ Context and principlePrevious results

Hadrontherapy : using ions (instead of photons)

[Amaldi et al.] [From IBA]

protontherapy IMRT

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▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives

▸ Context and principlePrevious results

Need for an online ion range control during carbon-therapy treatments

Stoichiometric calibrationPatient positioning Morphologic changesMoving organsIonisation potentials ...

Uncertainties on

Why ?

Uncertainties on real ion range

How ?MC simulations :Carbon ions range

<correlated to>Nuclear reactions

● PET, Prompt gammas● Prompt protons

Imaging

Prompt protons

Emitted :● High production yield● In forward directionCharged particules :● Easily trackable

Vertex

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▸ Proton Interaction Vertex ImagingMethodsResultsConclusions and perspectives

Context and principle▸ Previous results

Previous results on PIVI with Monte Carlo simulations [Henriquet et al. PMB (2012)]

Simulated setup

Primary vs secondaries verticescontribution

Falloff Position (IPP)correleted with

incident ions energy

A millimetric resolution achievable

Considering a typical spot for active delivery

(105 – 106 carbon ions)

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Proton Interaction Vertex Imaging▸ MethodsResultsConclusions and perspectives

▸ Hardware & software

A CMOS sensor based protons trajectometer coupled with a software analysis tool

1 plane = 2 CMOS sensors

Proton trajectometer is made with 4 planes

Mimosa 26 :a High Energy Physics CMOS pixel sensor

fitted for PIVI

● Thickness : 50 μm● Dimensions : 2 x 1 cm2

● Pixels : 1152 x 576● Pitch : 18,6 μm● Resolution : ~3,2 μm (sigma_{pos}(MIP))● Integration time : 112 μs● Dead Time : negligible

Clustering

Tracking

Vertexing

Ion trajectory Proton track

vertex

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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives

▸ Vertices distributions versus energyNormalized vertices distributions versus angleComparison with MC simulationsEffect of secondaries vertices

Carbon ions range in PMMA [HIT 2011]

10°

PMMA10x10x25cm3

10cm hodoscope

beam4 ≠ energies

PMMA TARGET

y

z

Z [mm]

Co

un

ts

160 mm range

12C ions @ 310 Mev/u FWHM 3.8 mm

● Vertices distribution along target depthcorrelated tocarbon ions range

● 2D vertices distributionscorrelated both tocarbon ions rangebeam FWHM

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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives

Vertices distributions versus energy▸ Normalized vertices distributions versus angleComparison with MC simulationsEffect of secondaries vertices

Tracker angle influence on statistic and reconstruction [GSI 2012]

10° to 50° 14cm

PMMA15(L) x 15(D) cm3

beam

12C @ 200MeV/u

z

y

PMMA TARGET

● Tracker anglecorrelated toreconstructed vertices yieldreconstruction artefacts (low angles)

Vertices yield vs tracker angle

Statistics for 1 pencil beam (106C - present setup)

20°

70 mm range

10°

20°

30°

40°

50°

5 trackers

2 trackers

1 tracker

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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives

Vertices distributions versus energyNormalized vertices distributions versus angle▸ Comparison with MC simulationsEffect of secondaries vertices

A reasonable agreement between experimental & MC simulation data

PMMA TARGET

70 mm range

10°

20°

30°

Experimental dataSimulation data

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Proton Interaction Vertex ImagingMethods▸ ResultsConclusions and perspectives

Vertices distributions versus energyNormalized vertices distributions versus angleComparison with MC simulations▸ Effect of secondaries vertices

A sensitive to secondaries vertices method

“Vertexing” method

Proton track

Ion tr

ajectory

Shorter segmentEstimatedvertex

PMMA TARGET

70 mm range

All verticesEstimated 1ary verticesEstimated 2ary vertices

30°

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Proton Interaction Vertex ImagingMethodsResults▸ Conclusions and perspectives

Conclusions

Ongoing work● Experiment with heterogenous target (QAPIVI collaborative project)

→ Analysis→ MC simulations

● Tests with large acceptance detector (F. Sauli et al.)

● Feasibility of PIVI technique in homogeneous targets→ First, studied with MC simulation [Henriquet et al. PMB (2012)]→ Then, we performed two experiments that are validating the principle→ The tracker angle influence on absolute vertices yields and reconstruction→ Reasonable agreement between experimental and simulated data

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Acknowledgments

Collaborations: ● IPNL-Lyon: M. Chevallier, G. Dedes, S. Deng, J. Krimmer, H. Mathez,

M. Pinto, C. Ray, V. Reithinger, E. Testa, Y. Zoccaratto● CREATIS-Lyon: N. Freud, J.M. Létang● GSI-Darmstadt: C. La Tessa, R. Pleczak, M. Vanstalle● HIT-Heidelberg: K. Parodi, I. Rinaldi, S. Brons● IPHC-Strasbourg: J. Baudot, M. Winter, C. Finck, M. Rousseau, R. Rescigno

Research program supported by:● PRRH ETOILE (CPER 2007-2013)● GDR MI2B (CNRS-IN2P3)● FP7 project ENVISION (2010-2013)● FP7 ITN project ENTERVISION (2011-2014)● Labex PRIMES (2012-2020)● INCA project QAPIVI (2011-2013)

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BACKUP SLIDES

2 experiments

TARGET

● PMMA (C5O2H8) 1.185g.cm-3

● Rectangular 10x10x25 cm3

[HIT 2011]● Cylinder 15Lx ¼(7,5R)

2 cm3

[GSI 2012]

BEAM● 12C6+ ions● 250 < E < 395 Mev/u

3.6 < FWHM < 4.3 mm

[HIT 2011]● 200 Mev/u

5 mm FWHM[GSI 2012]

TRACKER

● 8 CMOS sensors in 4 planes● 2 x 2 cm2 active area/plane● 10°

[HIT 2011] ● 10°< angle < 50°

[GSI 2012]

Plastic scintillator

● To detect protons crossing the tracker

● 7 x 7 cm2 active area● Used as CMOS trigger

(coincidence with hodoscope)

Beam hodoscope

● To detect incoming ions● Used as CMOS trigger

(coincidence with scintil.)

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BACKUP SLIDES

Protons Yield

Yie

ld [p

/C/m

sr]

Angle [degree]

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BACKUP SLIDES

Experiment correlation between Range & FallOff

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BACKUP SlidesClusters size

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BACKUP SlidesTracks resolution