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The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Protein Structure in Disease
and Therapy
Nicole Dickson
Michigan State University, Karolinska Institutet
EuroScholars Midstay Program
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Protein Structure in Disease
and Therapy
Nicole Dickson
Michigan State University, Karolinska Institutet
EuroScholars Midstay Program
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
The Role of G3BP
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Semliki Forest Virus (SFV) –
rmcvirology.blogspot.com
Chikungunya Virus (CHIKV) –
http://emdatabank.org/
Unfortunately…
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
The Problem…
http://www.natureworldnews.com/
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Fortunately…
Purified
proteinCrystallization
X-Ray Diffraction (old and new)
Electron Density MapFilling/FittingProtein Structure
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Published Results
Panas, M. D. (2014). Dissection
of virus-host cell interactions in
the early response to infection.
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
What we’re working on…
• Examination of both viral termini in binding G3BP
• Crystallization of CHIKV complexes
• Examination of binding mechanism of G3BP to the motifs
• Creating a clearer, more accurate model of G3BP binding to the
FGDF binding motif of SFV/CHIKV
The EuroScholars Program
A European Academic Research Experience
www.euroscholars.eu
Acknowledgements
Dr. Tim Schulte
Karolinska Institutet
Department of Medicine
Solna, Sweden
Dr. Adnane Achour
Karolinska Institutet
Department of Medicine
Solna, Sweden
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