Protein Paper Review

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  • 7/24/2019 Protein Paper Review

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    CHEM-GA 3010 Fall 2015Review Assignment

    Reviewer Name: Jonathan OswaldManuscrit title: Unraveling the Mechanism of Protein Disaggregation Through

    a ClpB-DnaK nteraction

    !lease ran" t#e manuscrit acc$r%ing t$ t#e criteria &el$w 'mar" wit# an ()* !lease ta"e int$acc$unt t#at articles s#$ul% re$rt unu&lis#e% w$r" t#at %escri&es new insig#ts an%+$rc$ncetual &rea"t#r$ug#s $, aeal t$ t#e rea%ers#i $, t#e $urnal

    !ot suita"le for pu"licationin chosen #ournal

    $uita"le for chosen #ournal

    %owest Moderate &igh Top '(

    $ignificance )

    !ovelt* )

    Broad interest )

    $cholarl* presentation )

    !lease res$n% t$ t#e ,$ll$wing'mar" wit# an ()

    +es !o n Part

    ,re the conclusions adeuatel* supported"* the data.

    )

    ,re the literature references appropriateand correct.

    )

    Do the contents #ustif* the length of themanuscript.

    )

    Rec$mmen%ati$n 'mar" wit# an ()Pu"lish without change

    ) Pu"lish after minor revisions

    /econsider after ma#or revisions

    Too preliminar* for pu"licationPu"lish elsewhere

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    Other0

    C$mments t$ t#e aut#$rs

    +our paper does a thorough #o" investigating the interactions of the proteins of1protein disaggregation23 using a revolutionar* !M/ method that allows fordetection of meth*l groups of particular amino acids4 found m*self wonderingwhat the true significance of this information was5 *ou presented the importanceof this understanding in a wa* that suggested have a thorough understanding of

    this topic alread*2 forgetting to highlight the grand scheme importance4 thin6what is highlighted is the importance of this !M/ techniue2 which can "e usedto stud* protein-protein interactions in a new2 convenient manner4