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DTL Partner Advisory Committee &
Topsector Life Sciences and Health Health~Holland
Pro~Motion & In~Motion
Prof. dr. Nico L.U. van Meeteren Executive Director
www.health-holland.com
@HealthHolland
Life Sciences and health Success and change …
2005 Benedictus XVI
Franciscus 2013
Alignment “If ‘I’ is replaced by ‘we’,
even illness turns into wellness”
Strategy building Pro~motion 2016-2019 … In~Motion 2016-2017 …
Health~Holland Ambitions
Programmatic Pillars
Alignement Disciplines, experts and institutions …
Alignment Scenario’s …
Alignement Cross-‘inners’ and cross-overs …
• Public Private Partnership: • Ñational:
• Inner: • AMR, CARDIO, Onco XL, etc.
• Over: • Agrofood, Chemics, CLICK NL, Energy, ICT, Logistics • Building blocks of life and IMDI • European Open Science Cloud
• International: • China, East-Africa, USA
• Communication • News-updates, Portal, Twitter, etc.
• Strategic Partnership • Interdepartemental (EA, Health, SA, etc.)
Programmatic Pillars
Running
• Enabling Technologies Call • ZonMw, LSH, ALW
• Data-Hub • Diverse set of publuc and private (LSH) partners
• FAIR Data Backbone • DTL, ICT, LSH, Min. Health and EA, etc.
Frontrunner
Continuum of participation Reform of acute care (waiting list … empowerment period)
- 1959 -
Strategy building Pro~motion 2016-2019 … In~Motion 2016-2017 …
Topsector Policies and progress …
LSH To do 2015-2016-2017 • Sector:
- Strategische en thematische Alignment - PPPs
– Onco XL, CARDIO, Bouwstenen van Leven, AMR, etc. - Financieringsscenario’s (Health impact bonds)
– TKI – Involveren Charity fondsen/Social Investors/Family funds, Pensioenfondsen,
Zorgverzekeraars, Overheden (P → PP), etc. - Internationaal
– In- en export LSH Portfolio (EU en Push op prio’s [USA, China, Oost Afrika] en Pull) - Communicatie
– Portal, news-updates, etc.
• Haags: - Interdepartementale alignment (o.a. EZ-VWS: Health Deals)
Building PPPs
• H~H PPPs: • Services, MedTech, (Bio)Pharma
• Per pillar • Between pillars (cross-‘inners’) • Between sectors (cross-overs)
• Agro-Food, Chemical, CLICKNL, HTSM. Logistics • Enabling technology ICT: COMMIT2DATA
• From Start up PPPs to Flagship PPPs
PPPs AMR …
• Opdracht: – VWS (i.o.m. LSH)
• Uitvoerder: – Innotact (Projectleider: Maarten van Dongen; [email protected])
• Proces en deliverable: – Contourenplan o.b.v. consultaties (oplevering 1 december) · Speerpunten en contouren van programma · Voorstel Governance en betrokken stakeholders
– Businessplan
• Participatie LSH: – Colja Laane (vanaf 1-11-’15 Nico van Meeteren)
TKI LUMC …
• TKI (k€) · Grondslag aangeleverd: Inzet-aanvragen toegekend:
- 2013: 0 118 - 2014: 0 0 - 2015: 0 246
- Vb: Marieke Bax: Molecular diagnostics in patients with Rheumatoid Arthritis – PPP 2015: 243 + 47
• UMCX - 2014: 8.500 2.00
IC 2016-2017 Zie: www.health-holland.com
• Beheren
• Beïnvloeden
• Verrijken
To do IMDI – LSH …
• To do - Samenwerking
- CoRs – Cross overs · HTSM
- Financiering – TKI · Proces en ‘targets’
– MKB regelingen · MIT · Netwerkbijeenkomsten
- Communicatie - Positionering en profilering
Systems development Rural and Urban Living Labs …
Health~Holland, In~Motion Dutch Topsector Life Science and Health
http://www.health-holland.com/portal
Success Biotech Partner Date Type Amount
ProFibrix Medicines Com. June 2013 M&A $90M upfront, $140M milestones
uniQure n.a. Jan 2014 IPO (Nasdaq) $92M
ArgenX n.a. Jul 2014 IPO (Euronext) $55M
Sapiens Medtronic Aug 2014 M&A $200M
Prosensa BioMarin Nov 2014 M&A $680M upfront, $160M milestones
ProQr n.a Sept 2014 IPO (Nasdaq) $97.5M
T-cell Factory Kite Mar 2015 M&A $21M
uniQure BMS April 2015 Licensing $50m upfront, $50 near term, $254M milestones plus $217M for other targets
AM-Pharma Pfizer May 2015 M&A $87.5M upfront, $512.5M milestones
Galapagos n.a. May 2015 PO (Nasdaq) $316,7M
Kiadis n.a. Jul 2015 IPO (Euronext) $37M
Merus n.a. Aug 2015 Series C financing $80.5M
Dezima Amgen Sept 2015 M&A $300M upfront, $1.25B milestones
Success
Success
H~H claim
Strategy building
• Limitations • Safety • Innovative alternatives • Smart use of data • Time for change
Better off With … cooperations …
• Breakthrough policy agreements • Health Deals
• Public Private Funding scenario’s • Health Impact Bonds
Future Think inside … continuate success …
“If ‘I’ is replaced by ‘we’, even illness turns into wellness”
Functioneren
Functioneren Life Span …
Func
tioni
ng
Time years of age
Major Life
Event
Functioneren (H)Orde …
Functioneren In health care … 0,0003% …
700.800 (80 x 8760)
200 (80 x 2,5)
How
Change Multi-facits strategie …
PPP Multipurpose professional …
Functioneren in health care Beter besef van en verbod op reductie van essenties …
Self
Jameson and Longo, 2015; Collins and Varmus, 2015
€↑
572
794 839
863 872 870 898
500
550
600
650
700
750
800
850
900
950
1000
2006 2007 2008 2009 2012 2013 2014
Continuum of success Reform …!
Paris, 2015
Irish – Dutch Exchange Programme Proposedi*neraryofexchangeprogramme• Monday22ndFebruary–Wednesday24thFebruary2016
• Monday22ndFebruary
DepartDublin13:25ArriveAmsterdam16:00Recep<onforIrishdelega<on• Tuesday23rdFebruary
VisitMaastrictUniversityHospital,RegionallivingLabs,Testbeds• Wednesday24thFebruary
VisitPhillips,examplesofsuccessfulPublicPrivatePartnerships(PPP’s),briefingwithNicovanMeeterenDepartAmsterdam20:30ArriveDublin21:10
Irish – Dutch Exchange Programme
• Visiting Delegation Provide profiles of delegation members for receiving parties Responsible for own overseas travel arrangements
• Receiving party Arranges collective meetings and fine-tunes programme Responsible for local transport When necessary will arrange or advise on lunches, dinners and hotel reservations.
DICA
• http://www.clinicalaudit.nl/jaarrapportage/2014/algemeen.html
(Kennis) en Innovatiecontract 2016-2017
Health~Holland (Topsector Life Sciences and Health)
www.health-holland.com
Van KIA naar (K)IC
• Kennis en Innovatieagenda 2016-2019
• Juni-augustus: Overleg stakeholders en partners LSH • Min. EZ, OCW, VWS; NFU; NRPO;
Regio’s; SGF; TNO; ZonMw-NOW, etc. • Augustus-september: IC drafts, checks en input TT, RG • 8 september: IC prefinal draft naar EZ t.b.v. Generiek IC • September: IC finaliseren
• Journalistieke bewerking • Makeup en lay-out • Correcties en aanvullingen
PDP, ZonMw-NWO, NWA, etc. • 5 oktober: Ondertekening Generiek IC bij Deltares • 6 oktober: IC H~H/LSH op website • Oktober: KIA-IC glossy summary
• (Kennis en) Innovatiecontract 2016-2017
Van KIA naar (K)IC
• (Kennis en) Innovatiecontract 2016-2017
• Oplegger
• Tabellen Indicatieve inzet 2016 en 2017
• IC-tekst:
• Hoofdlijnen en discussiepunten
• Detailcommentaar naar Nico [email protected]
• Proces • dd. …
To do • TKI succes 2014, 2015, 2016
• Charity fondsen/Social Investors/Family funds: - Social Impact Finance BV:
- Samuel Oudkerk - Kabinetsopdracht “Divident naar maatschappelijke doelen”
- Steven van Eijck, Guus Kramer en Paul Baan - Vermogensfondsen
- Rien van Gent
• Pensioenfondsen:
• Zorgverzekeraars:
Praktijkonderzoek HBO • Agenda Praktijkgericht Onderzoek Health
- Stuurgroep: – Edvard Beem, ZonMw – Geri Bonhof (Vz), RG LSH – Marieke Schuurmans, Chief Nursing Officer – Richard Slotman, NRPO
- Werkgroep – Karin Alfenaar (Secr) + … [email protected]
• Positieve dynamiek; kwaliteit, focus en massa; inhoudelijk gereed • Werksessie 7 oktober
- Bestuur, Directies, CoEs, Lectoraten - Agenda: gezamenlijke programmering, regie en werkafspraken - HCA: regie
– To do: rapportage LSH TKI-pilot Hanzehogeschool
• Publicatie Agenda (oktober) en presentatie RG (8 december)
Continuation of success
Change
For the worse or the better
Habemus
2005
2013
School
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