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ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY
Editorial Board:
NATHAN BACK, State University of New York at Buffalo
IRUN R. COHEN, The Weizmann Institute of Science
DAVID KRITCHEVSKY, Wistar Institute
ABEL LAJTHA, N. S. Kline Institute for Psychiatric Research
RODOLFO PAOLETTI, University of Milan
Recent Volumes in this Series
Volume 486 PURINE AND PYRIMIDINE METABOLISM IN MAN X
Edited by Esther Zoref-Shani and Oded Sperling
Volume 487 NEUROPATHOLOGY AND GENETICS OF DEMENTIA
Edited by Markus Tolnay and Alphonse Probst
Volume 488 HEADSPACE ANALYSIS OF FOODS AND FLAVORS: Theory and Practice
Edited by Russell L. Rouseff and Keith R. Cadwallader
Volume 489 HEMOPHILIA CARE IN THE NEW MILLENNIUM
Edited by Dougald M. Monroe, Ulla Hedner, Maureane R. Hoffman, Claude Negrier, Geoffrey F. Savidge, and Gilbert C. White II
Volume 490 MECHANISMS OF LYMPHOCYTE ACTIVATION AND IMMUNE REGULATION VIII
Edited by Sudhir Gupta
Volume 491 THE MOLECULAR IMMUNOLOGY OF COMPLEX CARBOHYDRATES-2
Edited by Albert M. Wu
Volume 492 NUTRITION AND CANCER PREVENTION: New Insights into the Role of Phytochemicals
Edited under the auspices of the American Institute for Cancer Research
Volume 493 NEUROIMMUNE CIRCUITS, DRUGS OF ABUSE, AND INFECTIOUS DISEASES
Edited by Herman Friedman, Thomas W. Klein, and John J. Madden
Volume 494 THE NIDOVIRUSES (CORONA VIRUSES AND ARTERIVIRUSES)
Edited by Ehud Lavi, Susan R. Weiss, and Susan T. Hingley
Volume 495 PROGRESS IN BASIC AND CLINICAL IMMUNOLOGY
Edited by Andrzej Mackiewicz, Madej Kurpisz, and Jan Zeromski
A Continuation Order Plan is available for this series. A continuation order will bring delivery of each new volume immediately upon publication. Volumes are billed only upon actual shipment. For further information please contact the publisher.
PROGRESS IN BASIC AND CLINICAL IMMUNOLOGY
Edited by
Andrzej Mackiewicz University School 0/ Medical Sciences GreatPoland Cancer Center Poznan, Poland
Maciej Kurpisz Institute 0/ Human Genetics Polish Academy 0/ Sciences Poznan, Poland
and
J an Zeromski University School 0/ Medical Sciences Department o/Immunology Poznan, Poland
Springer Science+Business Media, LLC
Library of Congress Cataloging-in-Publication Data
Progress in basic and clinical immunology/edited by Andrzej Mackiewicz, Maciej Kurpisz, and Jan Zeromski.
p. ; cm. - (Advances in experimental medicine and biology, ISSN 0065-2598; v. 495) "Proceedings of the 14th European Immunology Meeting (EFIS 2000) held September
23-27,2000, in Poznan, Poland"-T.p. verso. Includes bibliographical references and index. ISBN 978-1-4613-5194-8 ISBN 978-1-4615-0685-0 (eBook) DOI 10.1007/978-1-4615-0685-0
1. Immunology-Congresses. 2. Clinical immunology-Congresses. I. Mackiewicz, Andrzej. 11. Kurpisz, Maciej. III. Zeromski, Jan, 1938- IV. European Immunology Meeting (14th: 2000: Poznan, Poland) V. Series.
[DNLM: I. Immunity, Cellular-Congresses. 2. Autoimmunity-Congresses. 3. Dendritic Cells-physiology-Congresses. 4. Receptors, Immunologic-Congresses. 5. T-Lymphocytes-physiology-Congresses. QW 568 P964 2001] QR180.3 .P76 2001 616.07'9-dc21
2001038777
Proceedings of the 14th European Immunology Meeting (EFIS 20(0), held September 23-27, 2000, in Poznan, Poland
ISSN: 00652598
ISBN 978-1-4613-5194-8
©2001 Springer Science+Business Media New York Originally published by Kluwer Academic I Plenum Publishers, New York in 2001 Softcover reprint ofthe hardcover 1st edition 2001
http://www.wkap.nl
10 9 8 7 6 5 4 3 2 1
A C.I.P. record for this book is available from the Library of Congress
All rights reserved
No part of this book may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, microfilming, recording, or otherwise, without written permission from the Publisher
Contributors
Supporters • The State Committee for Scientific Research • Olympus Optical Polska Sp. z 0.0.
Contributors • Association for Fight Against Cancer "Genes For Life" • Becton Dickinson • CARL ZEISS Sp. z 0.0.
• GlaxoWellcome • GreatPoland Cancer Center • LOT - Polish Airlines • PPS Airpol Sp. Z 0.0.
• Talex SA • The Leopold Kronenberg Foundation • University School of Medical Sciences - Poznan • Wielkopolski Bank Kredytowy - WBK S.A.
Participants • Alexis Corporation • Nature Publishing Group • Preussen Electra Polska • SARSTEDT Sp. z 0.0.
• Sigma Aldrich Sp. Z 0.0.
v
vi Contributors
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• ADIS International Ltd.
• Becton Dickinson
• Bellco Biomedica Polska Sp. Z 0.0.
• Biker PTiO
• Biocom Systems s.c. • Biomibo
• Bio-RAD Laboratories GmbH, Prospecta Sp. Z 0.0.
• Birkhauser Publishers
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• CARL ZEISS Sp. Z 0.0.
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• Elsevier
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• MPW Med-instruments Sp. Pracy
• Nature Publishing Group
• Olympus Optical Polska Sp. z.o.o.
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• Science International
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Preface
Progress in Basic and Clinical Immunology is a result of the 14th European Immunology Meeting - EFIS 2000 held in Poznan, Poland on 23-27 September 2000. EFIS 2000 gathered over 1400 immunologists from all over the world. It was an exceptionally memorable meeting for a number of reasons: 1) it was held in the last year of the century and the millennium, thus provoking conclusions of past achievements of immunology and projections for the future; 2) it was held in Poland, a country that is a symbol of struggle for freedom for a large number of scientists originating from the "Eastern Bloc" countries and 3) EFIS celebrated its 25th anniversary at this occasion.
The scientific program included: Key Note Lecture by Peter Krammer (Germany), 9 State-of-Art Lectures including Rolf M. Zinkernagel (Switzerland) - Nobel Prize Laureate - lecture entitled "Immunity 2000", 14 Meet an Expert Sessions, 80 Plenary Lectures and 47 Workshops. Altogether 875 communications were presented. The philosophy of the scientific program did not follow the usual routine of immunology meetings. Topics of the plenary sessions were selected on the basis of recent developments rather than historical background. On the other hand Workshops were designed on the basis of abstracts submitted. We invited 117 authors to submit their presentations for publication in Progress in Basic and Clinical Immunology -62 were received and are included in this book. Most of the papers are related to the tumour immunology and immunotherapy that reflects a major focus of submitted abstracts for EFIS 2000. Of course, not all the very valuable communications could be included in the volume. However, we trust that the selection that we have offered will be at least in part
Vll
viii Preface
representative of the meeting and will pave the way for further developments.
Andrzej Mackiewicz Maciej Kurpisz
Jan Zeromski
Contents
T-CELLS
CD3-dependent regulation of early TCRn gene expression in mainstream aO and NKaO T cell development........... •••••••• ••• 5
Nicole Baur and Klaus Eichmann
Molecular characterization of gut T cell precursors in euthymic and athymic mice..................................................... ..... ... 15
Florence Lambolez and Benedita Rocha
CRTH2: marker for the detection of human Th2 and Te2 cells..... •••.•••••••••. •••••••••.••.•.•.. •••.•••••.•.•••••• •••••.••. •••.•.•• 2S
Lorenzo Cosmi, Francesco Annunziato, Grazia Galli, Roberto Manetti, Enrico Maggi and Sergio Romagnani
GILZ, a glucocorticoid hormone induced gene, modulates T lymphocytes activation and death through interaction with NF-kB.......... ........•...•........•..........••..................•••••. 31
Carlo Riccardi, Stefano Bruscoli, Emira Ayroldi, Massimiliano Agostini and Graziella Migliorati
Tyrosine phosphorylation of PICOT and its translocation to the nucleus in response of human T cells to oxidative stress.............................................................. .............. 41
Yael Babichev and Noah Isakov
ix
x Contents
IMMUNE RECEPTORS
The molecular specificity of IgG-Fc interactions with Fey receptors ................................................................ 49
Yusuke Mimura, Rodolfo Ghirlando, Peter Sonderrnann, John Lund and Roy Jefferis
Regulation of myeloid cell proliferation and survival by p75/ AIRMl and CD33 surface receptors. .... ..... ...... ...... .... ..... 55
Maria Cristina Mingari, Chiara Vitale, Chiara Romagnani, Michela Falco and Lorenzo Moretta
X-linked lymphoproliferative disease: the dark side of 2b4 function........................................................... ........ 63
Cristina Bottino, Silvia Parolini, Roberto Biassoni, Michela Falco, Luigi Notarangelo and Alessandro Moretta
ANTIGEN PRESENTATION / DENDRITIC CELLS
Role oftapasin in MHC class I antigen presentation in vivo............ 71 Natalio Garbi, Pamela Tan, Frank Momburg, Gunter J. Hiimmerling
Regulation of transporters associated with antigen processing (TAPs) by nucleotide binding to, and hydrolysis by, Walker consensus sequences......................................................... 79
Loredana Saveanu and Peter M. Van Endert
The AIR-J encoded class II transactivator (CIITA): the master coordinator of MHC class II gene expression and .. more..... .... ... 83
Roberto S. Accolla
Major histocompatibility complex class II (MHC II) expression during development of human fetal brain and haemopoietic organs..................................................... ................... ... 93
Teresa Wierzba-Bobrowicz, Elzbieta Kosno-Kruszewska, Eliza Lewandowska, Waldemar Lechowicz, Bogna Schmidt-Sidor
Interactions between dendritic cells...................................... .... 103 Stella C. Knight, Fiona Burke and Penelope A. Bedford
Contents Xl
Neural regulation of dendritic cell function.................... •.••........ 111 Georges 1M Maestroni
A central role for heat shock proteins in host deficiency .•••.••....••••• 121 Pramod K. Srivastava
CYTOKINES
Allele specific regulation of cytokine genes: monoallelic expression of the II..-IA gene......... ..•........•.••.•...•.....••....... ... 129
Comelis L. Verweij, Jean-Pierre Bayley, Aleida Bakker and Eric L. Kaijzel
Effect of polysaccharide sulfates on the production of interleukin-8 in an ex vivo model...................................... ••• 141
Pawel P. Jagodzinski, Wieslaw H. Trzeciak
Coordination of interleukin-6 biology by membrane bound and soluble receptors..... ...... ••.• •••.• •••.•••.. •..•..... ......•..••• •...•. 145
Stefan Rose-John
Termination and modulation of II..-6-type cytokine signaling.... ••• ..• 153 Peter C. Heinrich, Johannes Bode, Manuela Decker, Lutz Graeve, Astrid
Martens, Gerhard Miiller-Newen, Stefan Pflanz, Fred Schaper, Jochen Schmitz
Cytokine-induced STAT signalling through the cytoplasmic compartment.............................................................. .... 161
Pravin B. Sehgal
Cytokine-mediated growth inhibition of human melanoma cells...... 169 Marcin Kortylewski, Peter C. Heinrich, Andrzej Mackiewicz and Iris
Behrmann
Interleukin-6, tumor necrosis factor a and interferon.., in patients with anorexia nervosa........... ...•...........•..• •••••••....... 173
Renata Komorowska-Pietrzykowska, Andrzej Rajewski, Magdalena Sobieska and KrzysztofWiktorowicz
Interleukin-l system in testis - quantitative analysis..................... 177 Natalia Rozwadowska, Dorota Fiszer, Maciej Kurpisz
xu Contents
IMMUNODEFICIENCES
Mapping genes underlying complex disorders: progress on IgA deficiency and common variable immunodeficiency .................. 183
I. Vorechovsky, A. D. B. Webster, L. Hammarstrom
Ataxia-Telangiectasia ............................................ " ............. 191 Sara G. Becker-Catania and Richard A. Gatti
Gene therapy of severe combined immunodeficiencies.................. 199 Alain Fischer, Salima Hacein-Bey, Fran<;:oise Le Deist, Genevieve
De Saint Basile and Marina Cavazzana-Calvo
Immune reconstitution after highly active anti-retroviral treatment of HIV infection ................................................. 205
Brigitte Autran, Guislaine Carcelain and Patrice Debre
Dissimilarity of cinical signs with parameters characterizing immune system............................................................... 213
Natalia K. Gorlina, Anatoly N. Cheredeev, Ivan G. Kozlov, Alexander R. Guskov
AUTOIMMUNITY
The role of Fc receptors and complement in autoimmunity............ 219 Ulrich Baumann and Reinhold E. Schmidt
Effect of Hsp70-peptide complexes generated in vivo on modulation EAE .............................................................. 227
Grazyna Galazka, Agata Walczak, Tomasz Berkowicz and Krzysztof Selmaj
Gene transfer of protective cytokines in rheumatoid arthritis ......... 231 Oliver Distler, Christian A. Seemayer, Thomas Pap, Renate E. Gay,
Michel Neidhart, UlfMiiller-Ladner and Steffen Gay
Modification of humoral antisperm response.............................. 241 Beata Grygielska, Dorota Fiszer, Alina Domagala, Maciej Kurpisz
Contents xiii
ALLERGY / INFLAMMATION
Immunologic mechanisms of allergen-specific immunotherapy.. ...... 247 C. A. Akdis and K. Blaser
Phosphorothioate oligonucleotides: looking for the motif(s) possessing immunostimulatory activities in humans.................. 261
Francesca Brugnolo, Francesco Annunziato, Salvatore Sampognaro, Cinzia ManuelIi, Lorenzo Cosmi, Sergio Romagnani, Enrico Maggi and Paola Parronchi
Disorders in mononuclear phagocytes and reduced glutathione and their correction in Chernobyl children with recurrent respiratory infections and chronic inflammatory focal lesions.. ... 265
Viktor Chemyshov, Lyudmila Omelchenko, Gemot Treusch, Maxim Vodyanik, Tatyana Pochinok, Marina Gumenyuk, Gennady Zelinsky
IMMUNOTHERAPY
Adoptive transfer of mucosal T cells or dendritic cells from animals fed with cholera toxin B subunit alloantigen conjugate induces allogeneic T cell tolerance.................... ....... 271
Bin-Ling Li, Jia-Bin Sun and Jan Holmgren
Total body irradiation before bone marrow transplantation: aims and results................................... ............................ 277
Julian Malicki, Jacek Wachowiak, GraZyna Kosicka, Grazyna Stryczynska, Agnieszka Nowak and Jacek Pracz
Statins as immunomodulatory drugs........................................ 283 Andrzej Gorski, Monika Kasprzycka, Maria Nowaczyk, Piotr
Wierzbicki, GraZyna Korczak-Kowalska, Pawel Jezak, Danuta Klosowska, Aneta Ekiert, Konrad Klodos
VACCINES
Phage display of epitopes from HIV -1 elicits strong cytolytic responses in vitro and in vivo ........................................ ..... 291
John Guardiola, Piergiuseppe De Berardinis, Rossella Sartorius, Cristina Fanutti, Perham Richard N. and Giovanna Del Pozzo
XIV Contents
Oral immunization of human with transgenic lettuce expressing hepatitis B surface antigen................................................. 299
JozefKapusta, Anna Modelska, Tomasz Pniewski, Magdalena Figlerowicz, Kacper Jankowski, Olesia Lisowa, Andrzej Plucienniczak, Hilary Koprowski, Andrzej B. Legocki
Nasal administration of Schistosoma Mansoni egg antigenscholera toxin B subunit conjugate to infected mice reduces immunopathology and mortality ................................ 305
Jia-Bin Sun, Bin-Ling Li, Mekuria Lakew, Jean-Marie Grzych, Andre Capron, Cecil Czerkinsky and Jan Holmgren
Anti-influenza vaccination changes expression of CD45 isoforms on peripheral blood NK cells ofthe elderly............................. 311
Andrzej Mysliwski, Piotr Trzonkowski, Ewa Szmit, Anita Dobyszuk, Jolanta Mysliwska, Jerzy Foerster
TUMOR IMMUNOLOGY
Presence and functions of immune components in the tumor microenvironment. ...... ...... .... ... ..... ... ....... ..... .... ............ ... 317
Isaac P. Witz
Expression ofTCR ~ chain of tumor associated lymphocytes from malignant pleural effusions................................ ......... 325
Jan Sikora, Grzegorz Dworacki and Jan Zeromski
Cytochrome c is rapidly extruded from apoptotic cells and detectable in serum of anticancer-drug treated tumor patients.. ..... ...... .................. ...... ....... ........ ............. ... ... 331
Andrea Renz, ChristofBurek, Walter Mier, Malgorzata Mozoluk, Klaus Schulze-Osthoff and Marek Los
CD 56 (N-CAM) antigen and mRNA expression in human endocrine glands.......................... ................................. ... 335
Jan Zeromski, Renata Jenek, Zofia Niemir and Wlodzimierz Liebert
Contents xv
CANCER~UNOTHERAPY
Glycodendrimeric ligands of C-type lectin receptors as therapeutic agents in experimental cancer................. ............. 343
Miloslav Pospisil, Luca Vannucci, Anna Fiserova, Katherina Krausova, Ondrej Horvath, Vladimir Ki'en, Franco Mosca, Thisbe. K. Lindhorst and Karel Bezouska
Exosomes in cancer immunotherapy: preclinical data............ .... ... 349 F.Andre, M.Andersen, J. Wolfers, A. Lozier, G.Raposo, V.Serra,
C. Ruegg, C.Flament, E.Angevin, S.Amigorena and L. Zitvogel
Bone marrow dendritic cell-based anticancer vaccines.. ............ .... 355 Marie Indrova, Luis Mendoza, Milan Reinis, Vladimir Vonka, Michal
Smahel, Sarka Neme~kova, Tana Jandlova and Jan Bubenik
Dendritic cell-based vaccines for therapy of HPVl6-induced tumours........................................................................ 359
Jan Bubenik, Jana Simova, Vladimir Vonka, Michal Smahel, Romana Mikyskova and Luis Mendoza
Cytokine gene transfection for autologous and allogeneic melanoma vaccines.......................................................... 365
S Tocbyk, L Birchall, R Erlich, N Halanek, JK Orleans-Lindsay and A Dalgleish
Brain tumor treatment with IL-2 and IL-12 producing autologous cancer cell vaccines.............. ........................... ... 369
Szilvia Desaknai, Katalin Lumniczky, Egon J. Hidvegi, Hirofumi Hamada and Geza Safrany
IL-ll is a potent anti-melanoma factor............................. ........ 373 Hanna Dams-Kozlowska, Dariusz Izycki, Andrzej Mackiewicz
IL-6 and GM-CSF in tumor rejection model of renal cell cancer.................................................................... ...... 379
Piotr J. Wysocki, Dariusz W. Kowalczyk, Dariusz Izycki, Piotr Grabarczyk, Zbigniew K wias and Andrzej Mackiewicz
xvi
The effects of peri tumoral therapeutic vaccination with. IL-2-secreting cells on growth of MC38 colon tumours in mice, local NO production and sentinel lymph node cells
Contents
activation................................... .......................... .......... 385 Elzbieta Pajtasz-Piasecka, Halina Kusnierczyk, KrzysztofP. Krawczyk,
Egbert Piasecki, Martyna Elas and Czeslaw Radzikowski
Improving the retroviral vector (RV) systems for immunotherapy of cancer................................ .................. 389
Piotr Grabarczyk, Katarzyna Gryska, Piotr J. Wysocki, Dariusz IZycki and Andrzej Mackiewicz
Tumor immunity in mice immunized with fibroblasts transfected with tumor DNA................. ......... ... ...... ... ........ 393
Edwin F. De Zoeten, Donghua Li and Edward P. Cohen
T cell response to tumor antigens and its therapeutic use in cancer patients .............................. ~............................. .... 403
Giorgio Parmiani, Chiara Castelli, Piero Dalerba and Licia Rivoltini
Humoral responses to melanoma vaccine, genetically modified with interleukin 6 and soluble interleukin 6 receptor................ 411
Sergiusz Nawrocki, Maria Laciak, Dariusz IZycki, Katarzyna Gryska, Piotr J. Wysocki, Piotr Grabarczyk Aldona Karczewska, Aldona Kaczmarek, Pawel Murawa, Julian Malicki, Stefan Rose-John and Andrzej Mackiewicz
Clinical studies of human papilloma vaccines in cervical cancer .••••• 419 Malcolm Adams, Leszek Borysiewicz, Alison Fiander, Stephen Man,
Bharat Jasani, Hossein Navabi, Alan S Evans and Malcolm Mason
Flow cytometric cytotoxicity assay with GFP gene modified target cells..................................................................... 429
Dariusz IZycki, Katarzyna Gryska, Piotr Grabarczyk, Piotr J. Wysocki, Anna Jarosh'lska, Sergiusz Nawrocki Dariusz W. Kowalczyk and Andrzej Mackiewicz
Flow and video-imaging cytometry - usefulness of DNA ploidy measurements in diagnosis of malignant melanoma.................... 435
Janusz Skowronek, Zbigniew Karas, Roman M.Krenz, and Jerzy B. Warchol