26 & 27 March 2015 ANNOUNCEMENT

17th annual international clinical symposium Kempenhaeghe

2015

Epilepsy Sleep Neurocognition

Update@kempenhaeghe.nl

Therapeuticadvances

26 & 27 March 2015 ANNOUNCEMENT

17th annual international clinical symposium Kempenhaeghe

2015

Epilepsy Sleep Neurocognition

Update@kempenhaeghe.nl

SCIENTIFIC COMMITTEE

prof. dr. Bert Aldenkampprof. dr. Johan Arendsprof. dr. ir. Jan Bergmans

Dear colleagues,

The 17th edition of the annual international clinical symposium ‘Update@Kempenhaeghe.nl’ will take placeon Thursday 26 March and Friday 27 March 2015 in Heeze, The Netherlands. Over the past decade and a half, this symposium has become a major international scienti�c event in the Low Countries, hosting over 650 delegates in 2014. This year the focus will be on diagnostic and therapeutical advances.

During state-of-the-art main sessions, workshops and parallel sessions, recent progress in the diagnosisand treatment of epilepsy, sleep disorders and cognitive dysfunction will be discussed.

A distinguished national and international faculty guarantees a high quality of presentations and contentcovering best clinical practice, results of the latest scienti�c research and illustrative cases.

The main sponsor of the symposium is UCB Pharma.The parallel sessions of the sleep update are sponsored by BASS and NSWO.

On behalf of the scienti�c and organizing committee we warmly invite you to the 17th annual internationalclinical symposium ‘Update@Kempenhaeghe.nl’ and hope to personally welcoming you at Kempenhaeghe.

With best regards,

prof. dr. Paul Boondr. Laura Gottmer - Welschendr. Anton de Louw

prof. dr. Robert van Oostenbruggeprof. dr. Dirk Pevernagie

prof. dr. Paul Boon

director of Research & DevelopmentKempenhaegheprofessor of neurologyGhent University Hospital

prof. dr. Bert Aldenkamp

secretary of Research & DevelopmentKempenhaegheprofessor of epilepsy and neuropsychologyMaastricht University Medical Centerprofessor of cognition and imaging in epilepsyEindhoven University of Technology

& Main Sessions Epilepsy

F R I D AY 2 7 M A R C H 2 0 1 5

prof. dr. Simon Shorvon

MAIN SESSION EPILEPSY

ANTIEPILEPTIC DRUG TREATMENT

Chairs: prof. dr. Paul Boon, prof. dr. Bert Aldenkamp

Mechanisms of antiepileptic drugs, old and new dr. Henrik KlitgaardPractical use of new antiepileptic drugs prof. dr. Martin Brodie Mood effects of antiepileptic drugs prof. dr. Bert AldenkampInnovative administration of AEDs prof. dr. Paul Boon

prof. dr. Jan Hedner

MAIN SESSION SLEEP

TREATMENT OF SLEEP DISORDERS Chairs: prof. dr. Dirk Pevernagie, dr. Sebastiaan Overeem

Current state and future directions in hypoglossal nerve stimulation prof. dr. Nico de VriesPharmacotherapy for chronic insomnia: an update dr. Angelique PijpersPaediatric sleep apnoea: new therapeutic insights prof. dr. Stijn VerhulstTreatment of narcolepsy dr. Claire Donjacour

14.30 - 17.00

09.30 - 12.30

Sleep

09.00 - 09.30 WELCOME AND REGISTRATION

12.30 – 14.30 LUNCH AT HEEZE CASTLE

Parallel Sessions Epilepsy

F R I D A Y 2 7 M A R C H 2 0 1 5

PARALLEL SESSION 1 EPILEPSY

14.30 - 16.30

NEUROMODULATION

Chairs: prof. dr. Paul Boon, prof. dr. ir. Jan Bergmans

PARALLEL SESSION 2 EPILEPSY

14.30 - 16.30 TRANSLATIONAL RESEARCH IN EPILEPSY Chairs: dr. Govert Hoogland, dr. Rob Rouhl Blood-brain barrier dysfunction, seizures and epilepsy dr. Erwin van VlietImaging in animal models of epilepsy dr. Jaap JansenEffect of febrile seizures on hippocampal neurogenesis and GABA(A) dr. Ann Swijsen receptor physiology Translational research in epilepsy, quicker said than done? prof. dr. Ilse Smolders

PARALLEL SESSION 4 EPILEPSY

14.30 - 17.00 BIOMARKERS IN EPILEPSY

PARALLEL SESSION 3 EPILEPSY

14.30 - 16.30 NON-EPILEPTIC SEIZURES

Chairs: dr. Anton de Louw, dr. Nynke Bodde

First fit differential diagnosis in different cases dr. Mar CarreñoSyncope dr. Roland ThijsPsychogenic seizures versus epileptic seizures dr. Richard LazeronPsychogenic seizures: what else could it be? dr. Nynke Bodde

Chairs: dr. Jurgen Schelhaas, prof. dr. Alfred Meurs

Advances in the genetics of epilepsy and impact in clinical practice prof. dr. José SerratosaPractical use of a biobank in epilepsy care and research dr. Jurgen Schelhaas, dr. Peggy MandersNeurophysiological biomarkers for epilepsy prof. dr. Alfred MeursImaging biomarkers for epilepsy dr. Paul Hofman

(session in Dutch)

Neurostimulation strategies and mechanisms in epilepsy prof. dr. Robrecht Raedt Deep brain stimulation for epilepsy, what targets? dr. Kai LehtimäkiVagus nerve stimulation in children, a critical reappraisal prof. dr. Lieven LagaeTechnological advances in neurostimulation dr. ir. Pieter HarpeNon-invasive neurostimulation for epilepsy, what can we achieve? prof. dr. Werner Mess

PARALLEL SESSION 5 EPILEPSY

14.30 - 17.00 SPECIAL CASES: PHARMACOTHERAPEUTIC SUCCESS STORIES

Chairs: dr. Marian Majoie, dr. Mariëlle Vlooswijk

Prediction of successful pharmacological effects of CNS-active agents prof. dr. Joop van Gerven during early phases of drug development Can cortical excitability predict success of anti epileptic drug therapy? dr. Bert KleineSucces of first and second choice antiepileptic drug therapy based on dr. Cees van Donselaar guideline advises Successful treatment, patient satisfied? Annick LaridonSuper refractory status epilepticus, a success story dr. Joost Nicolai

Parallel Session Neurocognition

PARALLEL SESSION 1 NEUROCOGNITION

09.30 - 12.30 LANGUAGE, ATTENTION, SLEEP, FUNCTIONAL NETWORKS AND EXECUTIVE FUNCTIONS AND THEIR INFLUENCE ON LEARNING AND DEVELOPMENT

Chair: prof. dr. Hans Vles

F R I D A Y 2 7 M A R C H 2 0 1 5

S

PARALLEL SESSION 1 SLEEP

09.30 - 12.30 ORGANIZED BY NSWO

Parallel Sessions Sleep

09.00 - 09.30 WELCOME AND REGISTRATION

Consequences of dysfunctional networks related to development dr. Judith VerhoevenPrematurity and executive functions dr. Cornelieke Aarnoudse - Moens Motor disorders and language dr. Jeroen VermeulenSleep and learning Nele VandenbusscheParoxysmal symptoms and cognition Sylvia KlinkenbergDiagnosing attention problems in preschool children with a virtual Janneke Peijnenborghcomputer game Diagnostic overshadowing dr. Jos Hendriksen, prof. dr. Hans Vles

Programme will soon be published on www.kempenhaeghe.nl

PARALLEL SESSION 2 SLEEP

09.30 - 12.30 ORGANIZED BY BASS

Programme will soon be published on www.kempenhaeghe.nl

T H U R S D A Y 2 6 M A R C H 2 0 1 5 C O U R S E

‘Meet our talents’Innovation session

09.30 - 12.00 Innovation session for company leaders and others interested in innovation. By means of elevator pitches our young talents will introduce possibilities for innovation in epilepsy, sleep and neurocognition. For further information on the programme and registration please check www.kempenhaeghe.nl

AdvancedEpilepsy Course

ADVANCED EPILEPSY COURSE

14.00 -17.00 UPDATE ON EPILEPSY THERAPY

Chairs: prof. dr. Paul Boon, prof. dr. Bert Aldenkamp

Plenary sessionEpilepsy surgery, state-of-the-art prof. dr. Dirk Van Roost Management of acute seizures dr. Cees van Donselaar Combining antiepileptic drugs: rational polytherapy prof. dr. Martin Brodie Antiepileptic drug treatment, beyond seizure outcome prof. dr. Bert AldenkampVagus nerve stimulation, state-of-the-art prof. dr. Kristl Vonck Deep brain stimulation for epilepsy, when and how? prof. dr. Paul Boon

12.00 - 13.00 WELCOME AND REGISTRATION (including lunch buffet)(register separately; only open for academic professionals)

Breakup workshops based on cases

13.00 - 14.00 ON-SITE VISIT OF KEMPENHAEGHE

26 & 27 March 2015 ANNOUNCEMENT

17th annual international clinical symposium Kempenhaeghe

2015

Epilepsy Sleep Neurocognition

Update@kempenhaeghe.nl

Poster sessionA poster session will be organized. You can find information and instructions at www.kempenhaeghe.nl

VenueThe symposium ‘Update@Kempenhaeghe.nl’ will take place at Kempenhaeghe, Sterkselseweg 65, Heeze,The Netherlands.

If you have any questions, please contact thecommunication department of Kempenhaeghe at telephone+31(0) 40 227 92 82 or e-mail Update@Kempenhaeghe.nl

KempenhaegheP.O. Box 61Sterkselseweg 65NL- 5590 AB HEEZET +31 (0)40 227 92 82E Update@Kempenhaeghe.nlW www.kempenhaeghe.nl

Registration only at www.kempenhaeghe.nlPlease register for participation in the symposium‘Update@Kempenhaeghe.nl’ at Kempenhaeghe’swebsite www.kempenhaeghe.nl.On the website you will find further directions.First you will need to fill out the requested information,then you may choose between the different sessions.

CostsParticipation in the main and parallel sessions onFriday 27 March 2015 is free.

The fee for participants to the Advanced Epilepy Course is € 500,- .

AccreditationAccreditation from the Dutch and Belgian neurological accreditation committees and from the societies of physicians for persons with intellectual disabilities (ABC 1), pulmonologists, ENT-physicians, pediatricians, neurosurgeons, clinical neuropsychologists and nurse practitioners has been requested.

Sponsored by UCB Pharma B.V.

Facultydr. Cornelieke Aarnoudse-Moens Academic Medical Center, Amsterdam, The Netherlandsprof. dr. Bert Aldenkamp Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze and Maastricht; Eindhoven University of Technology; Ghent University Hospital, Belgiumprof. dr. ir. Jan Bergmans Eindhoven University of Technology, The Netherlandsdr. Nynke Bodde Department of Behavioural Sciences Kempenhaeghe, Heeze, The Netherlandsprof. dr. Paul Boon Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze; Ghent University Hospital, Belgiumprof. dr. Martin Brodie Western In�rmary, Glasgow, Scotlanddr. Mar Carreño Barcelona University Hospital Clinic, Spaindr. Claire Donjacour SEIN, Zwolle; Leiden University Medical Center, The Netherlandsdr. Cees van Donselaar Maasstad Ziekenhuis, Rotterdam, The Netherlandsprof. dr. Joop van Gerven Centre for Human Drug Research (CHDR), Leiden, The Netherlandsdr. ir. Pieter Harpe Eindhoven University of Technology, The Netherlandsdr. Jos Hendriksen Center for Neurological Learning and development disabilities Kempenhaeghe, Heeze, The Netherlandsdr. Paul Hofman Maastricht University Medical Center,The Netherlandsdr. Govert Hoogland Maastricht University Medical Center,The Netherlandsdr. Jaap Jansen Maastricht University Medical Center, The Netherlandsdr. Bert Kleine Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze, The NetherlandsSylvia Klinkenberg Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Maastricht, The Netherlandsdr. Henrik Klitgaard UCB S.A., Brussels, Belgiumprof. dr. Lieven Lagae Leuven University Hospital, BelgiumAnnick Laridon Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Oosterhout, The Netherlandsdr. Richard Lazeron Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze, The Netherlandsdr. Kai Lehtimäki Tampere University Hospital, Finlanddr. Anton de Louw Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze and Maastricht, The Netherlandsdr. Marian Majoie Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze and Maastricht, The Netherlandsdr. Peggy Manders Radboud University Medical Center, Nijmegen, The Netherlandsprof. dr. Werner Mess Maastricht University Medical Center,The Netherlandsprof. dr. Alfred Meurs Ghent University Hospital, Belgiumdr. Joost Nicolai Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Maastricht, The Netherlandsdr. Sebastiaan Overeem Center for Sleep medicine Kempenhaeghe, Heeze; Eindhoven University of Technology, The NetherlandsJanneke Peijenborgh Center for Neurological Learning and development disabilities Kempenhaeghe, Heeze, The Netherlandsprof. dr. Dirk Pevernagie Center for Sleep medicine Kempenhaeghe, Heeze; Ghent University Hospital, Belgiumdr. Angelique Pijpers Center for Sleep medicine Kempenhaeghe, Heeze, The Netherlandsprof. dr. Robrecht Raedt Ghent University Hospital, Belgiumdr. Rob Rouhl Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze and Maastricht, The Netherlandsdr. Jurgen Schelhaas Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze, The Netherlandsprof. dr. José Serratosa University Hospital Madrid, Spainprof. dr. Ilse Smolders Vrije Universiteit Brussels, Belgiumdr. Ann Swijsen Hasselt University, Hasselt, Belgiumdr. Roland Thijs SEIN, Heemstede, The Netherlandsprof. dr. Dirk Van Roost Ghent University Hospital, BelgiumNele Vandenbussche Center for Sleep medicine Kempenhaeghe, Heeze, The Netherlandsdr. Judith Verhoeven Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze, The Netherlandsprof. dr. Stijn Verhulst Antwerp University Hospital, Belgiumdr. Jeroen Vermeulen Maastricht University Medical Center,The Netherlandsprof. dr. Hans Vles Center for Neurological Learning and development disabilities Kempenhaeghe, Heeze; Academic Center for Epileptology, Kempenhaeghe/Maastricht University Medical Center, Maastricht, The Netherlandsdr. Erwin van Vliet Academic Medical Center, Amsterdam, The Netherlands dr. Mariëlle Vlooswijk Academic Center for Epileptology Kempenhaeghe/Maastricht University Medical Center, Heeze and Maastricht, The Netherlandsprof. dr. Kristl Vonck Ghent University Hospital, Belgiumprof. dr. Nico de Vries Sint Lucas Andreas Hospital, Amsterdam, The Netherlands; Dept Otolaryngology, University of Antwerp, Belgium