PROGRAM - TERMIS · • Jeff Lotz, PhD (University of California, San Francisco), Degeneration Models ... Speaker 2: Pierre Gianello, M.D. Ph.D. and Denis Dufrane, M.D. Ph.D. - University

The TERMIS North America 2008 Annual Conference

& ExpositionIn association with:

California Tissue Engineering Meeting

December 7 - 10, 2008Hyatt Regency La Jolla • San Diego, California

DISCOVER. DISCUSS. INTERACT.PROGRAMDISCOVER. DISCUSS. INTERACT.

Table of Contents

Welcome ……… 2

Pre-Conference Workshops & Opening Reception Sunday, December 7 ……… 6

Podium Presentations Monday, December 8 ……… 7-9

Podium Presentations Tuesday, December 9 ……… 11-13

Podium Presentations Wednesday, December 10 ……… 14-15

Poster Presentations I Monday, December 8 ……… 16-23

Poster Presentations II Tuesday, December 9 ……… 24-31

Student & Young Investigator Activities ……… 32-35

Exhibitors ……… 36-39

Sponsors ……… 40-42

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1

DISCOVER. DISCUSS. INTERACT.

December 2008

Dear Fellow TERMIS Members and Guests:

On behalf of TERMIS-NA, welcome to the annual North America meeting and to San Diego! This year, in addition to the conference’s traditional focus on tissue engineering, thereare special sessions on Stem Cells, Immunology, and Organ Engineering, emphasizingcritical areas of research for the future, and showcased by the three keynote lectures.We are pleased and excited to welcome our keynote lecturers: George Daley, MD, PhD, Children’s Hospital of Boston/Harvard Medical School; Megan Sykes, MD, Massachusetts General Hospital/Harvard Medical School; and Sanjay Nigam, MD,University of California, San Diego.

These keynote lectures, together with presentations from invited experts andpresentations from junior and new investigators, and the conference agenda offer newinsights from the thought leaders in tissue engineering and regenerative medicine.Altogether, the conference has 180 oral presentations, 425 poster presentations, 26exhibitors, and 16 sponsors. The meeting is being held in association with the CaliforniaTissue Engineering Meeting, and the attendees represent local, national (almost everystate is represented), and international (over 36 countries) participation. They include a mix of academicians, corporate professionals, and government representatives, with CEOs, principal investigators, post-doctoral fellows, pre-doctoral students, and otherresearchers. The conference provides an ideal setting for academic and corporate net-working, encouraging the formation of new exchanges and collaborations.

Pre-Conference Workshops will be held on the Sunday prior to the meeting. The intent of these Workshops is to have a detailed exchange of information and questioning in important topic areas that would benefit from additional focus. If theseworkshops are successful, they can be a continuing and important component of future TERMIS meetings.

The Student and Young Investigator Section of North America (SYIS-NA) has also organized a number of exciting activities at the meeting, specifically for newerinvestigators. The role of SYIS is to assist and encourage young researchers to networkand interact with experts in the field and to foster personal professional development.Please see the SYIS-NA schedule of events.

Tissue engineering and regenerative medicine are critical disciplines in the present and future global healthcare arena. The technology applications will be launchedat an increasing rate as the many disciplines synergize their efforts. The TERMIS-NAmeeting continues to grow and mature every year, and it has now become the majorvenue for the presentation of our research and its translation to clinical treatment thatbenefits the patient. We are looking forward to an exciting and productive meeting!

Anthony Ratcliffe, PhD Robert Sah, MD, ScD Bill Tawil, PhD2008 Scientific Co-Chair 2008 Scientific Co-Chair 2008 Conference Chair

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2 3

Sunday December 7th, 2008 10:00am-5:30pm

Hyatt Regency LaJolla, San Diego, California

(A preconference workshop offered prior to TERMIS NA Annual Conference

and Expo)

CO-ORGANIZERSAnthony Ratcliffe, Ph.D. (Synthasome)

Robert Sah, M.D., Sc.D. (UCSD) Fei Wang, Ph.D. (NIH-NIAMS)

PRE-REGISTRATION REQUIRED!Limited seating available. Register at

www.termis.org/na2008/workshop_nih.phpor contact Sarah Wilburn,

TERMIS Administrator, at 410.931.7838. Registration fee of $75.

Produced by Forecast Technology Group

AGENDAWELCOME & INTRODUCTION

PART 1: Moderator - Linda Sandell, PhD,(Washington University, St. Louis) –

Sessions I-III

Session I. Intervertebral Disc • Jeff Lotz, PhD (University of California,

San Francisco), Degeneration Models and Stem Cell Therapy.

• Koichi Masuda, MD (University of California,San Diego), Disc Degeneration Models and Advancement of IVD Therapiesinto Clinical Trials.

Session II. Ligament • Kurt Spindler, MD (Vanderbilt University),

Clinical Challenges for Ligament• Martha Murray, MD (Boston Children’s

Hospital), Translational Research for ACL Repair

Session III. Perspective from the FDA• Charles Durfor, PhD (CDRH, FDA) and

Richard McFarland, MD, PhD (CBER, FDA)

LUNCH

PART 2: Moderator - Richard Coutts, MD,(University of California, San Diego) –

Sessions IV and V

Session IV. Articular Cartilage • Constance Chu, MD (University of Pittsburgh),

Orthopedic Challenges of Cartilage Injury and Degeneration and Solutions throughTranslational Research

• Timothy M. Simon, PhD (Applied Biological Concepts, Inc) Testing in a Surrogate Animal Model

The National Institute of Arthritis and Musculoskeletal and Skin Diseases(NIAMS) of the National Institutes of Health (NIH), TERMIS NorthAmerica, and Forecast Technology Group are delighted to invite you to attendthis specialty workshop, in advance of TERMIS North America 2008.

This event will be a unique workshop that addresses translational models for muscu-loskeletal tissue engineering and regenerative medicine, including the target tissuesof bone, cartilage, disc, ligament, meniscus, muscle, and tendon, the clinical needsand opportunities, appropriate models, and translational pathways to the clinic.

BACKGROUND:Researchers have made substantial advances in musculoskeletal tissue engineering,and are beginning to translate this into potential products addressing critical clinicalneeds. Translational research will need a set of experimental models to assess effi-cacy and effectiveness, enabling the potential products to move toward clinical trials.

PURPOSE:• Identify translation models and research and development pathways for engineered musculoskeletal tissues and regenerative medicine therapies that target bone, cartilage, disc, ligament, meniscus, muscle, and tendon.• Identify gaps in our technology toolkit to enable researchers to appropriately testefficacy and effectiveness of tissue engineered/regenerative medicine therapies.

WHO SHOULD ATTEND?All musculoskeletal researchers (scientists, bioengineers, clinicians) who have aninterest in translational research, moving basic research toward applications, andassessing the efficacy and effectiveness of potential new treatments.

• Lori Setton, PhD (Duke University), Strategies for Drug Delivery to PromoteCartilage Regeneration

Session V. Muscle and Tendon• Herman Vandenburgh, PhD (Brown

University), Tissue Engineering Contractile Tissues for Clinical Applications

• Kathe Derwin, PhD (Cleveland Clinic), Animal Models for Rotator Cuff Tendon Repair

COFFEE BREAK

PART 3: Moderator - Christine Kelley, PhD,(NIH-National Institute of Biomedical Imaging and Bioengineering) –

Sessions VI and VII

Session VI. Meniscus• Tom Carter, MD (Arizona State University),

Clinical Challenges for Meniscus Repair and Regeneration

• Steve Arnoczky, PhD (Michigan StateUniversity), Translational Models for Studying Meniscus Repair: What they Can and Can’t Tell Us

Session VII. Bone • George Muschler, MD (Cleveland Clinic),

Orthopedic Challenges and Stem CellTherapies for Bone Regeneration

• Eddie Schwarz, PhD (University ofRochester), Gene Therapies for Bone Regeneration

• Dietmar Hutmacher, PhD (QueenslandUniversity of Technology), TranslationalTherapies for Bone Regeneration

SUMMARY & CLOSING REMARKS

TRANSLATIONAL MODELS

for MUSCULOSKELETAL TISSUE ENGINEERING and

REGENERATIVE MEDICINE

Group Sponsors

TERMIS North America, in conjunction with the Juvenile DiabetesResearch Foundation and Forecast Technology Group is proud to invite you to attend this premiere specialty workshop, in advance of TERMIS North America 2008.

This premiere event is a unique “experiential meeting” addressing the emerging field of beta cell replacement therapy, including the studies of stemcell differentiation, tissue engineered constructs for islet transplantation, and encapsulation technologies for immuno-isolation.

OVERVIEW:Pancreatic islet transplantation has been efficacious in select patients inimproving metabolic control and quality of life, and in preventing severe hypoglycemia in patients with “brittle” or difficult-to-control type 1 diabetes.Despite improvements made thus far, major scientific and technical challengesremain that must be addressed before beta cell replacement will be widelyincorporated into the clinical management in established type 1 diabetes. It is thought that the field will benefit from the involvement of bioengineers by applying quantitative and rational engineering principles to improvingaspects of beta cell replacement therapy, such as immunoisolation and higher efficiency at deriving beta cells from stem cells. At this workshop the attendeeswill be able to understand the state of the art and the remaining challenges. Funding opportunities from the JDRF in this area will also be announced.

BENEFITS:• Learn about the current progress and challenges in islet transplantation• Learn about the current progress and challenges in generating

replenishable pancreatic beta cells • Explore collaboration among bioengineers/chemists/material scientists and

transplanters/beta cell biologists/immunologists/stem cell biologists• Discover JDRF Beta Cell Replacement program funding opportunities

WHO SHOULD ATTEND?All bioengineers, material scientists, and chemists who have an interest in and apply their expertise toward the study of transplantation immunology, stem cell differentiation, and beta cell biology.

PRELIMINARY AGENDASESSION 1: Challenges in Islet Transplantation

Speaker 1: Bernhard Hering, M.D. - University of Minnesota*Bioengineering approaches to improve islet transplantation

Speaker 2: Bo Nilsson, M.D. - Uppsala University HospitalExtrahepatic transplantation of insulin producing cells

Speaker 3: William Lowe, M.D. - Northwestern UniversityMicroporous polymer scaffolds for the extra-hepatic transplantation of islets

Speaker 4: Norma Sue Kenyon, Ph.D. - Diabetes Research InstituteEngineering Alternative Sites for Islet Transplantation:

Cells, Scaffolds and DevicesDiscussion

SESSION 2: Encapsulation for Immuno-isolation

Speaker 1: Riccardo Calafiore, M.D. - University of PerugiaImmunoprotection of human islet allografts by high performance

alginate-based microcapsules

Speaker 2: Pierre Gianello, M.D. Ph.D. and Denis Dufrane, M.D. Ph.D. - University of Louvain Medical School

Diabetes correction by pig islet monolayer device in non-human primates

Speaker 3: Daniel Anderson, Ph.D. - Massachusetts Institute of Technology*High-throughput generation of novel cell encapsulation materialsDiscussion

SESSION 3: Generating Renewable Beta Cell Sources

Speaker 1: Anne Bang, Ph.D. - Novocell, Inc.*Generating beta cells from human embryonic stem cells

Speaker 2: Shay Soker, Ph.D. - Wake Forest Institute for Regenerative Medicine*Generating beta cells from human adult stem cells

Speaker 3: Vincenzo Cirulli, M.D. Ph.D.*ECM, cell-cell interactions, and in vitro cultures for beta cellsDiscussion

* Indicates title is not final

http://

TISSUE ENGINEERING andBIOMATERIALS TECHNOLOGIES

to IMPROVE BETA CELL REPLACEMENT

Sunday December 7th, 2008 1:00 - 5:00 pm

(A preconference workshop offered prior to TERMIS NA Annual Conference

and Expo)

CHAIRGordon Weir, M.D.

(Joslin Diabetes Center)

ADVISORY PANEL Anthony Ratcliffe, Ph.D. (Synthasome)

Robert Sah, M.D., Sc.D. (UCSD)Albert Hwa, Ph.D.

(Beta Cell Replacement Program Manager, JDRF)Julia Greenstein, Ph.D.

(Beta Cell Replacement Program Director, JDRF)

SPECIAL EVENTSJoin the opening cocktail reception of TERMIS

North America 2008 Conference and Expo following the program.

(Pre-registration Required)

FEESThere will be no registration fee for this program

thanks to the generosity of the sponsors. Advancedregistration is required due to limited seating.

Note: Separate registration required from the TERMIS NA Conference and Expo.

Association Partners:

Produced and Co-sponsored by Forecast Technology Group

www.conferencestrategists.com

REGISTER NOW! http://termis.org/na20084 5PRE-CONFERENCE WORKSHOPS Sunday, December 7, 2008

Pre-Conference Workshops and Opening Reception – Sunday, December 7, 200810:00 am - 5:30 pm Translational Models for Musculoskeletal Tissue Engineering

& Regenerative Medicine - Located in Salon FSponsored by NIH/NIAMS/NIBIB/NINDS and Forecast Technology Group Inc.

1:00 pm - 5:00 pm Tissue Engineering and Biomaterials Technologies to Improve Beta Cell Replacement - Located in Salon ESponsored by JDRF and Forecast Technology Group Inc.

6:00 - 8:00 pm Welcome Reception & Exhibit Viewing - Located in Pavilion

6:15 - 6:30 pm Opening Remarks - Located in Pavilion

Podium Presentations – Monday, December 8, 20088:00 am PLENARY I: Opening Keynote Address: Hematopoietic Stem Cells

George Daley, MD, PhD, Children's Hospital of Boston/Harvard Medical School

9:00 am Coffee Break with Poster Viewing

SESSION10:00 -

11:30 am

Synthetic and Biologic Scaffolds

Stem Cells - (MSCs,Adult Stem Cells,

Embryonic Stem Cells) I

Microvascularizationand Angiogenesis I

Wound Healing I

SESSIONCHAIRS

Glenn Prestwich and Robert Mauck

Arnold Caplan and Jennifer Elisseeff

Elliot Chaikof and Lucie Germain

Tony Atala, JoachimKohn and Col Vandre

ROOM Salon G Salon D Salon E Salon F

10:00 am The Temporal Behavior ofElectrospun, Multi-PolymerNanofibrous Composites

Robert Mauck

Adult and Embryonic StemCells in Musculoskeletal

Tissue EngineeringJennifer Elisseeff

New Biomaterial Options for VascularTissue Engineering

Elliot Chaikof

The Armed ForcesInstitute of Regenerative

Medicine (AFIRM)Robert Vandre

10:15 am Cell and Tissue In-growthBehavior into n-HA/PCL

Composite ScaffoldFabricated by LMS:

Comparison with Conven-tional SGP Scaffolds

through Animal StudiesSu-Jin Heo

Structural and Functional Interactions

of Stem Cells and Cardiomyocytes

Nenad Bursac

Engineering Tissues with Capillaries

to Improve Organs Reconstructed In Vitro

Lucie Germain

The Armed ForcesInstitute

of Regenerative Medicine (AFIRM)

Tony Atala andJoachim Kohn

10:30 am Cells in Gels: Exploring CellularMorphogenesis

and Differentiation in 3-D CultureDror Seliktar

Effects of ModulatingCanonical Wnt Signaling

on the In Vitro Performance of Human Bone

Marrow-Derived ConnectiveTissue Progenitor Cells

Brett Hoover

Deployment of Progenitor CellsEduardo A. Silva

Engineered Epidermal Growth

Factor Mutants Enhance Wound Healing In Vitro

and In VivoStayce Beck

10:45 am Scaffolds PresentingIntegrin-Specific

Biomimetic Ligands Inhibit MSC

ChondrogenesisJohn Connelly

The Effect of Transcriptional

Reprogramming on In Vitro Aging of Human

Mesenchymal Stem Cells

Lisa Boyette Braswell

Endothelialized Modules Drive

Vascularization in an Allogeneic Rat Model

Rohini Gupta

Chimeric Composite Skin Substitutes for

Delivery of AutologousKeratinocytes

to Promote TissueRegeneration

Cathy Rasmussen

11:00 am Macrophages are Essential to the

Degradation andRemodeling of ECM

Scaffolds In VivoJolene Valentin

Directed Control of Multiple Developmental

Pathways Promotes Human Embryonic Stem

Cell-Derived CardiomyocyteDifferentiationOscar Abilez

Coculture Organization intoVascular Network

within Macroporous PEG-Fibrinogen Hydrogel

Tamar Kaully

Differentiation of Adipose Derived

Stem Cells intoEpithelial-Like

CellsShanmugasundaram

Natesan

11:15 am EngineeredExtracellular Matrices

for Regenerative Medicine

Glenn Prestwich

Efficient Recovery of Endothelial Progenitors

for Clinical TranslationBryan Tillman

Role of S1PReceptor-Specific

Activation in Microvascular

RemodelingLauren Sefcik

Injectability of Biodegradable,

Porous PolyurethaneScaffolds for

Tissue RegenerationAndrea Hafeman

11:30 am Exhibit Viewing • Box Lunches Available for Purchase in the Pavilion

6 7

Each attendee is required to check-in at the 2008 TERMIS NA Conference registration desk.

Photo ID is required at check-in.

The registration desk will be open at the following times:Saturday, December 6 from 5:00pm - 7:00pmSunday, December 7 from 5:00pm - 7:00pm

Monday, December 8 from 7:00am - 5:00pmTuesday, December 9 from 7:00am - 5:00pm

Wednesday, December 10 from 7:00am - 12:00pm


Podium Presentations – Monday, December 8, 2008SESSION

3:00 - 4:30 pm

Printing andStereolithography for 3D Scaffolds I

Cell Tracking & Imaging

Cardiovascular andVascular Tissue

Engineering I

Dental, Oral andCraniofacial Tissue

Engineering I

SESSIONCHAIRS

Scott Hollister and Vlad Mironov

Jeremy Mao and Joseph Frank

Robert Tranquillo and Ren-ke Li

Ken Yamada andStephen Feinberg


3:00 pm Session IntroductionVladimir Mironov

Magnetic Labeling of Stem Cells for Detection

by Cellular MRI: Potential Applications in Regenerative Medicine

Joseph Frank

Cell Tracking and Cell Ratio Optimization

for Cardiac Tissue Engineering

Rohin Iyer

PharmacologicalManipulation of an Oral Mucosa

Progenitor/Stem CellPopulation

Stephen Feinberg

3:15 pm Quality of 3D-PrintedTissue ConstructsThrough Enhanced

Mixing of Alginate Hydrogels

Daniel Cohen

In Vivo Tracking of Quantum-dot Labeled

Human Mesenchymal Stem Cells

in SCID MiceBhranti Shah

Cardiac Fibroblast Co-culture EnhancesContractile Function

of Engineered MyocardiumKevin Costa

Salivary GlandDevelopment

and ReconstitutionKenneth Yamada

3:30 pm Three-dimensionalScaffold Fabrication

by Indirect Micro-stereolithography

Using VariousBiomaterials

Hyun-Wook Kang

Surveillance of Systemic Trafficking

of Macrophages Induced by UHMWPE Particles in Nude Mice by IVIS

Pei-Gen Ren

Cell-Induced Alignment of Fibrin Gel-Based

Myocardial Equivalents Yields Unexpected

Improvement in Contraction ForceRobert Tranquillo

Osteogenic Potential of Adipose

Stem Cells on Electrospun

FibrinogenMichael Francis

3:45 pm High-ThroughputProduction of

Single-Cell HydrogelMicroparticles

Using Inkjet PrintingTechnology

Tao Xu

Micro Imaging System for Analyzing

the Biomechanics of Engineered Tendons

In VivoGadi Pelled

Microfabricated CardiacTissue Patch

with Tunable Structure and Function

Nenad Bursac

Computer-DesignedHybrid Scaffolds

for Periodontal TissueInterface Generation

Chan Ho Par

4:00 pm Modeling of Cell Damage in the

Bio-Dispensing-BasedScaffold Fabrication

Daniel Chen

Influence of Corneal Fibroblasts

on the Mechanical Behavior

of Collagen HydrogelsMark Ahearne

Synergistic Effect of Cells and Cytokines

on Tissue Formation and Regeneration AfterCardiac Repair Using

a Novel Cell EngineeredBiodegradable Scaffold

Ren-Ke Li

Insulin-producing Cells (IPCs)

from Dental-PulpStem/Progenitor Cells

Chang Hun Lee

4:15 pm Scaffold Engineering: A Bridge to Where?

Scott Hollister

Uptake and Intracellular Fate of Metals Encapsulated

in Carbon Nanotubes within Cells

Magdalena Swierczewska

Chemical Biology of Stem Cell Cardiogenesis

Mark Mercola

Craniofacial BoneTissue EngineeringUsing rAAV-BMP2-

Coated CalvariaAllograftsDan Gazit

4:30 pm Exhibit Viewing & Refreshments/Poster Session I from 5:00 pm - 6:30 pm

Podium Presentations – Monday, December 8, 2008SESSION

1:00 - 2:30 pm

Smart Biomaterials I

Cell Regulation and Microenvironment

Soft Tissue Repair I

Musculoskeletal Tissue Engineering I

SESSIONCHAIRS

Shelly Sakiyama-Elbert and Molly Stevens

Joanne Murphy-Ullrich and Ali Khademhosseini

Steve Badylak andKaren Burg

Heinz Redl and Rita Kandel


1:00 pm Smart Materials for Musculoskeletal

Regeneration Molly Stevens

The Role of the Calreticulin-Binding

Sequence of the Matricellular Protein,Thrombospondin-1,

in Regulating Cell Behaviorand Tissue RemodelingJoanne Murphy-Ullrich

A Blastema-likeApproach

to Mammalian TissueRegeneration

Stephen Badylak

Injectable Thermosensitive

Chitosan Based Scaffolds for Musculoskeletal

Tissue RegenerationLakshmi Nair

1:15 pm DegradablePhotocrosslinked

Fibrous Scaffolds withTunable Macro-Porosity

and Drug DeliveryJason Burdick

Microengineered Hydrogels for Bottom-up

and Top-down Tissue Engineering

Ali Khademhosseini

Engineering Tissues for Ex Vivo Application

Karen Burg

Regenerating theIntervertebral Disc: From Impossible

to ProbableRita Kandel

1:30 pm Enzymatically Cross-linked Collagen as a Tissue Scaffold

David Chau

The Role of Geometry in Stem Cell FateKristopher Kilian

Scaffold Treatment with

SDF-1α (CXCL12)Diminishes the

Immune ResponsePaul Thevenot

Nucleus Pulposus CellsMaintain Laminin 10/11

and Its Receptor Lu (CD239) Expression

During Cell Culture In Vitro

Lori Setton

1:45 pm Engineered Protein Hydrogels

for Neural Stem CellTransplantation

Sarah Heilshorn

Chemoattraction ofProgenitor Cells by

Remodeling ExtracellularMatrix ScaffoldsThomas Gilbert

Biologic ScaffoldRemodeling

and Macrophage Response

in a Rat ModelBryan Brown

Synovial Joint Replacement In Vivo without Cell Trans-

plantation: Locomotion and Weight Bearing

Chang Hun Le

2:00 pm Polarization of Hydroxyapatite

Scaffolds; Influence on Osteoblast

Cell Proliferation and Extracellular Matrix ProductionSarah Cartmell

The Use of Skeletal Muscle

Extracellular Matrix Extract to Study the Influence

of an Aging Environment on the Regenerative Capacity of Skeletal

Muscle Progenitor CellsMatthew Stern

In Vitro 3D Model for Human

Vascularized Adipose TissueJennifer Kang

Repair of Segmental Bone Defects

Using Electrospun Nanofiber Meshes

Yash Kolambkar

2:15 pm The Effects of GrowthFactor Delivery and

Embryonic Stem Cell Transplantation on Spinal Cord Injury

Shelly Sakiyama-Elbert

Degradation and Vessel Formation

in Glycated Collagen Gels

In VivoMegan

Francis-Sedlak

intentionally left blank

A Regeneration-Competent Animal Model to Study Musculoskeletal

Regeneration and Malformation

Bingbing Li

2:30 pm Break with Poster Viewing

8 9

Podium Presentations – Tuesday, December 9, 20088:00 am PLENARY II, Keynote Address: Transplantation Tolerance: From Animal Models to Clinical Studies

Megan Sykes, MD, Massachusetts General Hospital/Harvard Medical School

9:00 am Coffee Break with Poster Viewing • Host - Covidien

SESSION 10:00 -

11:30 am

Smart Biomaterials II

Transplantation,Immunology and

Cancer

Neural TissueEngineering I

Wound Healing II

SESSION CHAIRS

Joe Tien and Andrea Gobin

Jeffrey Platt and Sudha Agarwal

Molly Shoichet and Diane Hoffman-Kim

Cheng-Ming Chuong and Conan Young


10:00 am Development of Biomimetic Hydrogels for Guided Endothelial Cell Morphogenesis,Organizations and Vessel Formation

Andrea Gobin

On the Fate of Stem CellsJeffrey Platt

Biomaterials for Spinal Cord Injury Repair

Molly Shoichet

Development of rhPDGF-BB Based

Drug/Device CombinationProducts for

the Treatment of Orthopedic Injuries

Conan Young

10:15 am Treatment of Neuro-Inflam-mation by a Thermally-

Sensitive Tumor NecrosisFactor Alpha Antagonist

Lori Setton

Tissue Engineered Models of Axon

GuidanceDiane Hoffman-Kim

Caspase-8 Regulates SkinRegeneration

and Wound RepairPedro Lee

10:30 am 3D Elastomeric Engineered Tissues

with Aligned, Interconnected Pore Structures

Ali Khademhosseini

Human PrimaryOsteoblast Matrices as a

Paradigm for Tumor/Bone Microenvironment

ResearchDietmar Hutmacher

Nanofibrous Scaffold for Spinal Cord RegererationaEugene Zhu

New Pre-clinical Models of Physiological and

Pathological CutaneousProcesses Based on

Skin Tissue EngineeringFernando Larcher

10:45 am Developing Injectable and Bio-absorbable

Thermally ResponsiveHydrogels: Synthesis of Poly (NIPAAm-co-

AAc-co-HEMA-PTMC) and Poly (NIPAAm-co-

HEMA-co-MA-PLA)Zuwei Ma

Development of a 3D Culture System

to Study the SkeletalMetastatic Process

of the Prostate Cancer (CaP)Shirly Sieh

Lactic Acid ImpactsReactive Oxygen Species Effects

on Neural Precursor Cells and Their Development in MonolayerKyle Lampe

Large-scale Production of Inductive Dermal Papilla Microtissues

for Hair FollicleRegeneration Via

Biomaterial FacilitatedSelf-assemblySung-Jan Lin

11:00 am Fundamental Studies of Artificial Extra Cellular

Matrix Composed of Laminin-derived

SequenceSachiro Kakinoki

A Strategy for Generating

Antigen-specific T Cells

for ImmunotherapyBrenda Ogle

Design of GuidanceScaffolds Containing

Minimal Topographic Cuesto Promote Endogenous

Bridging of Long Peripheral Nerve Gaps

Isaac Clements

Improving PostnatalVasculogenesis

Restores Diabetic Wound Healing

Robert Allen, Jr.

11:15 am Bioactive Nanostructures for

Regenerative Medicine and Cancer Therapies

Ramille Capito

Compressive ForcesControl Inflammation

by Regulating Activation of NF-κB TranscriptionFactor in Chondrocytes

Jin Nam

Femtosecond LightPatterned Hydrogels

for Tissue EngineeringRyan Wylie

Forming Hair from Wounds

Cheng Ming Chuong

11:30 pm Exhibit Viewing • Box Lunches Available for Purchase in the Pavilion

10 11

Notes


Podium Presentations – Tuesday, December 9, 2008SESSION

3:00 - 4:30 pm

Nanotechnology forTissue Engineering

Cell Therapy Microvascularizationand Angiogenesis II

MusculoskeletalTissue Engineering II

SESSIONCHAIRS

JJ Hickman and Jennifer West

George Muschler andMarc Hedrick

Christopher Chen and Shayn Peirce

Rocky Tuan and Lori Setton


3:00 pm Temporal NeurotransmitterConditioning and

Neuroprotection by Ceria Nanoparticles

Enables Adult Rat Spinal Cord

Neuron RegenerationJames Hickman

Optimizing Assays for Colony

Forming Cells?Applications in Stem

Cell Biology and Tissue EngineeringGeorge Muschler

Adipose-derived StromalCells as Perivascular

Support Cells During Angiogenesis and Arteriogenesis:

Mechanisms ofRecruitment and

Therapeutic ImplicationsShayn Peirce

Artificial Neural Network Modeling of

Elastin-Like PolypeptideParameter Effects on Gel Mechanical

Properties, Cellular Metabolism,

and BiosynthesisLori Setton

3:15 pm Controlled Release of Retinoic Acid and Nerve Growth Factor from Nano-Pattern for

Neuronal RegenerationKim Kiat Teo

Adipose Based Cell Therapy

Marc Hedrick

Regulation of CapillaryEndothelial Cell Function

by the Adhesive and Mechanical

MicroenvironmentChristopher Chen

Adult Stem Cells and Nanomaterials

in Skeletal Tissue Engineering and Regeneration

Rocky Tuan

3:30 pm Nanoparticlesfor Cellular Imaging

Jennifer West

Doping Self-Assembling

Peptide Hydrogels with Collagens Promotes

Chondrogenesis ofMesenchymal Stem Cells

Eric Vanderploeg

A Tissue Engineered Model of Intestinal

Lacteals for Characterizing

Lipid and NanoparticleUptake and Transport

J. Brandon Dixon

Passaged Human Chondrocytes

Can be Induced to form Hyaline Cartilage

In Vitro Nazish Ahmed

3:45 pm The Effect of Single Wall Carbon Nanotube

Facilitated ThermoacousticStimulation on

Marrow Stromal Cells Danielle Green

Long Term Expansion of Pluripotent HumanEmbryonic Stem Cells

in a Suspension Bioreactor

Culture SystemRoman Krawetz

Formation of DurableVascular Networks within 3D Scaffolds:

Implications for Engineered Bone

Olga Tsigkou

Composition of Biodegradable

Composite ScaffoldsDirects In VivoOsteogenesis

and AngiogenesisJiawei He

4:00 pm Nanotechnology for Improving Tissue

Regeneration: A Collection

of In Vivo StudiesThomas Webster

Treatment of Muscle Stem Cells with N-acetylcysteine

Increases Survival andResistance to Stress

Lauren Drowley

Vascularization of Microfluidic Type I

Collagen GelsJoe Tien

A Hydrogel-Mineral Hybrid Scaffold

for Osteochondral Interface

Tissue EngineeringNora Khanarian

4:15 pm Nanofiber-Based Scaffold System

for Tendon-to-BoneIntegration

Kristen Moffat

Tissue Engineered Adrenal Gland-adrenal

Sphere CellShigeyuki Furuta

Use of EndothelialProgenitor Cells and

Mesenchymal Stem Cellsfor Engineering

Long-lasting FunctionalBlood Vessels In Vivo

Patrick Au

Biomaterial GuidedCartilage Repair in a Goat ModelBlanka Sharma

4:30 pm Exhibit Viewing & Refreshments//Poster Session II from 5:00 pm - 6:30 pm

Podium Presentations – Tuesday, December 9, 2008SESSION

1:00 - 2:30 pm

Printing andStereolithography for 3D Scaffolds II

Stem Cells - (MSCs, Adult Stem Cells,

Embryonic Stem Cells) II

Soft Tissue Repair II

Dental, Oral andCraniofacial Tissue

Engineering II

SESSIONCHAIRS

Ben Wu and Dietmar Hutmacher

Johnny Huard and Sylvia Evans

David Kaplan and Martha Murray

Pam Yelick and George Huang


1:00 pm 3D Printing of Tissue Engineering

Scaffolds? Challenges andOpportunities

Ben Wu

Regenerative Medicine Based

on Muscle Stem CellsJohnny Huard

Lactic Acid ImpactsReactive Oxygen Species

Effects on Neural Precursor Cells and TheirDevelopment in Monolayer

Kyle Lampe

Strategies for Whole Tooth

Tissue EngineeringPamela Yelick

1:15 pm Determining Engineering Parameters

for Inkettable Biological Inks

Thomas Boland

A Myocardial Lineage Derives from Tbx18

Epicardial CellsSylvia Evans

Synthesis and Character-ization of Hyaluronic Acid-based Injectable

Bio-degradable Hydrogels for Soft Tissue Repair

Kacey Marra

Stem Cell-mediated De Novo Regeneration of Human Dental Pulp

George Huang

1:30 pm Generation of Durable

Tissue Constructs Using a Novel Hybrid

Printing SystemTao Xu

Amniotic Fluid-derived Stem Cells

for Regeneration of Infracted Rat

MyocardiumXuan Guan

Evaluation of a Tissue Engineered

Urethral Wrap Following

ImplantationDonna Haworth

In Vivo Osteoconductiveand Osteoinductive,

Carrier Filled, 3D Printed, Bone Scaffolds for

Custom Bone Repair and ReplacementElizabeth Clark

1:45 pm Computer Simulation of Angiogenesis in a Printed-typeScaffold Predicts Load-dependent

Vascular Invasion and Osteogenesis

Sara Checa

Myospheres, Stem Cells for Muscle

Karen Westerman

Translational Studies

of Enhanced ACLReconstruction

Braden Fleming

Tooth Tissue Engineering:

Kinetic of Vascularization

Adnane Nait Lechgue

2:00 pm Maskless Fabrication of Masters and

Poly(dimethyl siloxane)Stamps for the

Micro-contact Printing of Proteins and Cells

Imen Elloumi Hannachi

Synthetic Oxygen Carriers Enhance

the Survival and Osteogenic Potential

of Genetically Modified MSCs Zulma Gazit

Rotator Cuff RepairAugmentation

in a Canine Model Using a Woven PLLA Device

Kathleen Derwin

Investigation of the Effects of Laser

Microgrooves and Arginine-Glycine-AsparticAcid (RGD) Coating on the Interfacial Strength

of Ti-6Al-4V PinsMohamad Alkhodary

2:15 pm What is the Future for Advanced Design

and Fabrication of 3D Scaffolds in

Tissue Engineering and Regenerative

Medicine?Tim Woodfield

Chondrogenic Differentiationof Embryonic Stem Cells and Adult Mesenchymal Stem Cells: Associations

Among Contraction, SmoothMuscle Actin Expression,

and Chondrogenesis In VitroKaren Shu

Bedside to Bench: In Vitro to In Vivo

Soft Tissue Engineering

David Kaplan

Tissue Engineering a Human Ear ModelFollowing Seeding

of Different Chondrocytes

Noritaka Isogai

2:30 pm Break with Poster Viewing • Host - Lonza

12 13

Podium Presentations – Wednesday, December 10, 2008SESSION

10:45 -12:00 pm

Product Developmentand Commercializationof Tissue Engineering

(Co-Sponsored by AABB)

Organ TissueEngineering

Neural TissueEngineering II

Tissue Engineeringand Regenerative

Medicine in the Clinic

SESSIONCHAIRS

Dave McKenna and Sharon Presnell

Doris Taylor and Linda Griffith

Ravi Bellamkonda andMark Tuszynski

Nicholas L'Heureux and James Yoo


10:45 am Molecular and CellularTherapeutics of the

University of Minnesota:Facilitating the

Delivery of Therapies from Bench to Bedside

David McKenna

Formation of Functional Tissue:

Endothelialized Modules Containing

MSC or IsletsDean Chamberlain

Sustained and Local Delivery of

Thermostabilized chABCfor Treatment After Spinal Cord Injury

Ravi Bellamkonda

The First CompletelyBiological and

Autologous Tissue Engineered

Blood Vessel for Human Use

Nicolas L'Heureux

11:00 am Targeted R&D in the Development

of Neo-Organ Products for Regenerative Medicine

ApplicationsSharon Presnell

BiomechanicalInvestigation of an Optimal

Sterilization MethodTomohiro Ota

Templated AgaroseScaffolds Orient andGuide Regenerating

Long-Tract Axons Through Sites

of Spinal Cord InjuryMark H. Tuszynski

Clinical Application of Tissue Engineering

Vascular Grafts in Pediatric

Cardiac SurgeryToshiharu Shinoka

11:15 am Development of Identity and Potency Assays

for Autologous Cell Therapy Products

for Cartilage RepairStephen Duguay

Fully Biological Bioprinted

Blood VesselsCyrille Norotte

Influence of Topographyon the Regenerative

Phenotype of Peripheral Nerve Cells

Vivek Mukhatyar

Phase I/II Study of a New Autologous

Transplantation Method for Vitiligo Treatment

Wendy Chen

11:30 am CommercializationRequirements

for Regenerative Medicine ProductsPawanbir Singh

Engineering Organs

Using Nature's Platform

Doris Taylor

Structurally Modified AcellularScaffolds PromotePeripheral NerveRegeneration in a Rabbit Model

Paulina Sierpinski

Histologic Evaluation of a Stem Cell BasedSinus Bone Grafting

Procedure for Dental Implant

ReconstructionBradley S. McAllister

11:45 am Liver Tissue Engineering with Inverted Colloidal

Crystal Scaffolds for In Vitro Toxicity Testing

Jungwoo Lee

Capturing Complex Liver Inflammatory

Phenotypes In Vitro

Linda Griffith

3D Photo-Engraving of Guidance

Micro-Channels into Hydrogels for

Directed Neural Invasion Offra Sarig-Nadir

Clinical Translation of Urologic Tissues

James Yoo

12:00 pm Adjournment

Podium Presentations – Wednesday, December 10, 20088:00 -

9:00 amPLENARY III, Keynote Address: Kidney Organ EngineeringSanjay Nigam, MD, University of California, San Diego

9:00 am Coffee Break

SESSION9:30 -

10:45 am

Bioreactors andMechanical Training of Tissue Constructs

Gene Therapy andTissue Engineering

Cardiovascular andVascular TissueEngineering II

Endocrine andMetabolic Tissue

Engineering

SESSIONCHAIRS

Al Banes and GordanaVunjak-Novakovic

Dave Mooney andEdward Schwarz

Marc Mercola and Jan Stegemann

Athanassios Sambanisand Fred Levine


9:30 am A Novel Rotational Vacuum Seeding Device

(S-RVSD) for Porous Tubular Scaffolds

Lorenzo Soletti

Oligonucleotide Uptake:

Roles of Packaging and Cellular Context

David Mooney

Strategies to ImproveProtein-Based

Scaffolds for Cardiovascular Tissue Engineering

Jan Stegemann

Genetically EngineeredNon-Pancreatic Cells

for PhysiologicallyResponsive Insulin

SecretionAthanassios Sambanis

9:45 am Controlled Cyclic Stretching to Enhance

Mechanical and Compositional Properties

of Tissue Engineered Heart Valves

Zeeshan Syedain

Independent and HighLevel Dual-gene

Expression from DoublePromoter Lentivirus forHigh-throughput and

Real-time Dynamic GeneExpression Profiling

Jun Tian

Combination of Muscle-derived Stem

Cells and BiodegradableScaffolds for ArterialTissue-engineeredVascular Grafts in

Rat and Pig ModelsAlejandro Nieponice

High-ThroughputScreening

for Molecules that Modulate

Insulin Promoter Activity

Fred Levine

10:00 am Bioengineering of Lubricious Synovial Fluid

in a Biomimetic Bioreactor

Robert Sah

Adenylate-Cyclase VITransforms Ventricular

Cardiomyocytes Into Biological

Pacemaker CellsArjang Ruhparwar

Tissue EngineeredVascular Adventitia with Vasa Vasorum

(TEVAwVV) DrasticallyImprove Implanted

Graft Perfusion Via Inosculation

Maxime Guillemette

Covalently LinkedAlginate/PEGMicrocapsules

for Islet EncapsulationCherie Stabler

10:15 am Bioreactor for Application of Strain to Cells in Three

Dimensional CollagenHydrogels: Test Bed

for Modeling Strain Effects in Osteoblast-Mediated Gel

Compaction, Development ofTissue Engineered Tendons

and High Throughput 3D Culture Systems

Albert Banes

Endostatin Transfection

of Mesenchymal Stem Cells in

Plasmid-SupplementedCollagen Scaffolds

Lily Jeng

Engineering Small-Diameter

Nanofibrous Vascular Grafts

Song Li

Autologous Cell-based Liver

Tissue EngineeringKazuo Ohashi

10:30 am Tissue Engineering Bioreactors with

Biologically Inspired Physical Stimulation

Regimes Gordana

Vunjak-Novakovic

Inhibition of Multidrug-Resistant

Acinetobacter Baumannii by Non-ViralExpression of hCAP-18

in a BioengineeredHuman Skin Tissue

Lynn Allen-Hoffmann

Blood OutgrowthEndothelial Cells

in Vascular Tissue

EngineeringKatherine Ahmann

Scalable Differentiation

of Human EmbryonicStem Cells to

Endodermal ProgenyEmmanuel Tzanakakis

14 15

42Development of a Field-ReadyAntimicrobial Wound Dressing for the Treatment of CutaneousVesicant InjuriesBarry Steiglitz

43Inhibition of Protease Activity by a Skin Substitute Tissue Engineered to Express TIMP-1Christina Thomas-Virnig

Smart Biomaterials

44Laser-Activated Surgical Bioadhesivefor Sutureless Nerve AnastomosisLeslie Foster

45Silk Fibroin and Chitosan-Flap Composite with Entrapped Drug for Tissue Reconstruction in Cancer TreatmentVishal Gupta

46Induction of Mucosal ImmuneResponses with Scleroglucan-coatedMicroparticlesHyun-Chul Lee

47Combined Laser-Activated SurgicalBioadhesive and DecellularizedTissue Scaffolds for EnhancedWound Repair and TissueRegenerationHelder Marcal

48Effect of Polyvinyl Alcohol and Sodium Hypochlorite on Porosity and Hydrophilicity of PLGA Hollow Fibre Membrane ScaffoldsGiulia Meneghello

49Mechanical and BiologicalCharacterization of A NewBiopolymer for Soft TissueEngineeringFrancesco Migneco

16Expansion of Human Ovarian Cancer Cell Lines and PrimaryHuman Mesenchymal Cells Under Different Media ConditionsVerena Quent

17Controlled Delivery of Stem CellsUsing Magnetic Particle Technology -an In Vitro Circulatory ModelHarpal Sura

Microvascularization and Angiogenesis

18PEGylated Fibrin-guided VascularOutgrowth from Aortic TissueScott Collins

19Stimulation of Wound Vascularizationby Skin Tissue Engineered to SecreteElevated Levels of Angiogenic FactorsAllen Comer

20Oxygen Tension Influences theProangiogenic Potential of Cells of the Endothelial LineageMartin Decaris

21The Use of Adipose-derived StemCells to Stimulate Angiogenesis for Tissue EngineeringSuraj Kachgal

22Endothelial Cell Contractility and ECM Density Influence CapillaryMorphogenesis and MaintenanceEkaterina Kniazeva

23Optimization of Alginate MicrobeadProperties for Sustained Release of Angiogenic ProteinMonica Moya

9Novel Polyvalent Integrin a5b1 Ligands Improve Cell Adhesion in 2D and 3D Cell CultureZhaohui Li

10A Multicellular 3D Culture Model toStudy Mammary Ductal FormationMaricel Maffini

11Three-Dimensional Co-culture Systemof Hepatocytes and Fibroblasts Using Microchip TechniqueYusuke Sakai

12Culture of Ventral Midbrain NeuralProgenitors in Hyaluronic Acid Hydrogels with Tunable Material PropertiesStephanie Seidlits

13A Combinatorial Effect of AdhesiveProtein Coating and Plasma Modifi-cation on Osteoblast Differentiation for Polycaprolactone ScaffoldsEda Yildirim

Cell Tracking and Imaging

141H Spectroscopic Analysis of hMSC Microenvironment in a 3D Perfusion BioreactorJason Crowe

15Non-Invasive Visualization of Mesenchymal Stem Cell Chondrogenesis by MultiphotonAutofluorescence (MAF) and Second Harmonic Generation (SHG) MicroscopyChen Yuan Dong

POSTER SESSION I • Monday, December 8, 2008 • 5:30 - 6:30 pm 24Bioactive Surfaces to ModulateEndothelial Cell Responses in a Three Dimensional EnvironmentGeorges Sabra

25Accelerating Angiogenesis in Poly-caprolactone Scaffold by Delivery ofVascular Endothelial Growth FactorShivani Singh

26Digital Volumetric Imaging of Angiogenesis in Tissue Engineered ConstructsMarc Takeno

27Development of Scaffolds andBioreactor to Grow PatternedMicrovessel NetworksPatrick Vermette

28Angiogenic Gene Modification ofSkeletal Muscle Cells to Compensatefor Age-related Decline in FunctionZhan Wang

29Regenerative Medicine Approach tothe Treatment of Radiation CystitisKoudy Williams

30Therapeutic Angiogenesis for TissueRegeneration and Limb IschemiaUsing Non-viral Modified Stem CellsFan Yang

Skin and Wound Healing

31Antimicrobial Resistance Reversal at Physiologic Temperatures in MRSA Present in the NaresUtilizing an 870 nm and 930 nm Dual Wavelength Noveon® LaserEric Bornstein

32Comparison of Titanium Mesh andDacron Cuffs in a SubcutaneousRabbit ModelKelly Chapman

33Novel Anisotropic Wound HealingAssays Using Nanogrooved Substrates and 3D EngineeredTissuesKevin Costa

34Innovations in 3-D Bioreactors for Wound Healing and Regenerative MedicineIra Herman

35Characterisation of ICX-SKN During Manufacturing for Process Optimisation and Product ImprovementJasmin Kee

36Healing Effects of Epigallocatechin-3-O-gallate (EGCG)on Burn Wounds in MiceHakHee Kim

37In Vitro Expanded Living SkinMatrices for ReconstructionMichell Ladd

38Effect of Cultured Epidermal Graft(Kaloderm®) on Diabetic WoundHealingEun Jung Oh

39Comparative Proteomic AnalysisBetween Normal Skin and Keloid Scar(update 2008)Chee Tian Ong

40Organotypic Cultures of Human Skin Explants with a Fixator Pin-biomaterial InterfaceAntonio Peramo

41A Combination of a Novel PorcineCollagen Paste Dermal Substitute with Cultured Keratinocytes and Split Skin Grafts to Treat Experimental Full-Thickness WoundsRostislav Shevchenko

16 17


1Hypoxic Culture in Vascular Tissue EngineeringJason Bjork

2Role of the Extracellular Matrix in Vascular DifferentiationAlicia Blancas

3The Role of the Stromal Cells and Laminin-1 in Mammary EpithelialCell Phenotype in 3D culturesAdeline Cabaton

4Primary Human Chondrocyte Cultureon Gelatin- and Gelatin/HyaluronicAcid-based MicrocarriersJune Chun

5A Simple Approach for Micro-patterning Dual-HydrogelConstructs on Permeable Membranes for 3D CulturesJabe Curley

6Effects of Diabetes on Properties of Type I Collagen Gels and Cell BehaviorMegan Francis-Sedlak

7Preventing Negative Effects of Hypoxia on Connective TissueProgenitor CellsChristopher Heylman

8The Biological Behavior of Human Dermal Fibroblasts on Submicro-patterned FibronectinChun-Ho Kim

50Sustained Release of Growth Factorsfrom a Composite Ceramic Scaffold:Implications for Bony EngineeringPhuong Nguyen

51Sustained-Release Silk Biomaterialsfor Tissue Engineering ScaffoldsEleanor Pritchard

52A Method Based on Multiphoton-Excitation to Direct-Write BioactivePeptides for Cellular GuidanceStephanie Seidlits

53In Vivo Biocompatibility SelectionAlginates for Bioartificial PancreasTransplantationSophie Veriter

54Oxygen Generating Biomaterials for Enhancing Cell SurvivalCatherine Ward

55Investigation of Regenerative ImplantsDerived from HeterologousBin Xu

Soft Tissue Repair

56Ventral Hernia Repair with Cross-linked vs. Non-cross-linkedPorcine Acellular Dermal MatricesNadja Burns

57Modular Approach to Adipose TissueEngineering Using a Semi-syntheticCollagen/Poloxamine HydrogelMark Butler

58Adipose Tissue Engineering Mediated by Genetically EngineeredMesenchymal Stem CellsZulma Gazit

59Biodegradable Elastomeric Scaffoldsfor Closure of Pathological Fistulasand Patent ForaminaAlison Hart

60Quantitative Magnetic ResonanceImaging of Native and Stem Cell-Based Tissue-EngineeredAnnulus FibrosusGadi Pelled

61Adipogenic Differentiation of Adipose Stem Cells Cultured on Amniotic MembraneAnnemari Salonen

62Development of a Cotton Ball-likeDrug-eluting Electrospun Fiber for Accelerating the Healing of Anastomotic ArteriesMakoto Satake

63Differential Growth Factor Expressionin Traumatically-Injured SkeletalMuscle from C57BL/6 and CCR2-/- MiceGordon Warren

64Adipose Tissue Formation in Vitro and in Vivo Using Human BoneMarrow Stromal CellsXuebin Yang

Stem Cells (MSCs, adult stem cells, embryonic stem cells)

65Creating Retinal Tissue in 3D with Defined Factors using Adult Retinal Stem CellsShoeb Ahsan

66Effects of Shear Stress on Embryonic Stem Cell DifferentiationTaby Ahsan

67Biomimetic Self-Assembled Nano-matrix for Bone Tissue RegenerationJoel Anderson

68Infection of Amniotic Membrane Cellsfrom Golden Retriever MuscularDystrophic Dogs (GRMD) with a Recombinant Retrovirus Carrying LacZ GenePatricia Beltrão-Braga

69Differentiation of Urine-Derived Pro-genitor Cells to Smooth Muscle Cellsfor Urological Tissue EngineeringShantaram Bharadwaj

70Osteogenic Differentiation of HumanUrine-derived Progenitor CellsShantaram Bharadwaj

71Differentiation of Human Bone MarrowStromal Cells into Cells with aUrothelial Phenotype: Potential Use in Urinary Tract Reconstruction for Bladder CancerShantaram Bharadwaj

72Cord Blood Derived EndothelialProgenitor Cells Adherence andProliferation Under Laminar FlowMelissa Brown

73Induction of Heme Oxygenase-1Expression Increases Survival ofHuman Embryonic Stem Cell-derivedCardiomyocytes During HypoxiaBaohong Cao

74Mesenchymal Stem CellsDifferentiation into Osteoblasts on 2D and in 3D Fibrin ScaffoldsMelissa Chow

75New Limbal Stem Cell MarkersRosa M Corrales

76Effect of Substrate and Strain onSignal Transduction Gene Expressionin Human Adult Mesenchymal Stem CellsAdele Doyle

77Transplantation of Composite Stem Cells and Collagen Matrix to Reconstitute Muscular DefectDenis Dufrane

78BioPEGylation of Polyhydroxy-alkanoates Promotes Satellite Stem Cell CyclingLeslie Foster

79Adipose Tissue-Derived Stem andRegenerative Cell Transplantation:Intervertebral Disc Repair in a Canine ModelTimothy Ganey

80Adult Horse and Pig Peripheral Blood Progenitors CellsRicardo García

81Transplantation of Neural CrestProgenitor CellsCarrie Geisbauer

82Effect of Fluid Flow-Induced ShearStress on Mesenchymal Stem CellGene ExpressionJohn Glossop

83Effect of Uniaxial Tensile Strain on Mesenchymal Stem Cell Gene ExpressionJohn Glossop

84Unexpected Severe Calcification afterMyocardial Infarction is Not Causedby Amniotic Fluid Derived Stem CellsXuan Guan

85Cardiac Microenviroment ProgramHuman Aminotic Fluid-Derived StemCell to Express Cardiac PhenotypeXuan Guan

86Comparison of Bioactive Glass/polymer and b-TCP/polymerComposite Scaffolds on the Growthand Osteogenic Differentiation of Adipose Stem CellsSuvi Haimi

87Mesenchymal Stem Cells for Vascular Tissue Engineering:Effect of Organismal Aging on Gene Expression Profile and Functionality of Vascular GraftsJuhee Han

88Reduced Oxygen Tension InhibitsOsteogenesis but Enhances the Proangiogenic Potential of Human Adipose Derived StemCells in Three DimensionsJiawei He

89Ethanol Enhances OsteogenicDifferentiation of Human AmnioticFluid-derived Stem CellsJennifer Hipp

90Colonyze: Customizable QuantitativeCell Assay Analysis SoftwareBrett Hoover

91Human Surface Antigens ofMesenchymal Stem Cells in Swine and Equine IndividualsClemente Ibarra

92The Biological Factors Identified in HepG2-CM; Their StimulatoryEffects During OsteogenicDifferentiation of mESCsYunyi Kang

93MSC Enhance Allogeneic IsletEngraftment in Nonhuman PrimatesNorma Kenyon

94Effects of Intermittent HydrostaticPressure on the Chondrogenesis of Mesenchymal Stem Cells Through 3D Co-cultureDong Hwa Kim

95Targeting Mesenchymal Stem Cells to Activated Endothelial CellsIn Kap Ko

96A Candidate for Organ Specific Stem Cells that Restricted Cell Diameter 2 to 5 µm in Adult Pancreas in Non-obese Diabetic MiceShohta Kodama

97Generation of Pneumospheres from Pulmonary Stem CellsKoji Kojima

98In Vivo Bone Formation FollowingTransplantation of Human Adipose-derived Stromal Cells That Are Not DifferentiatedOsteogenicallySoo-Hong Lee

99Opposing Roles for Rho/ROCKSignaling in TGF-beta- VersusInsulin-induced Chondrogeneis In VitroMatthew Ludeman

100Direct Separation of Stem CellSubpopulations on a Novel Ligand-immobilized ColumnAtsushi Mahara

18 19

POSTER SESSION I • Monday, December 8, 2008 • 5:30 - 6:30 pm

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101Human Facilitative GlucoseTransporters (SLC2A proteins) - a New Generation of PhysiologicalMarkers for Mesenchymal Stem CellDifferentiation to Adult ChondrocytesAndrei Manolescu

102Hydrodynamic Modulation ofEmbryonic Stem Cell DifferentiationTodd McDevitt

103Derivation of a Novel UndifferentiatedPhenotype in Human Fetal Femur-Derived Cells with a Serum-Free Chemically DefinedMedium and BMP-2: Implications for Ex Vivo Expansion StrategiesSayed-Hadi Mirmalek-Sani

104Generation of Functional Hepatocytes from ES Cells in a Hollow Fiber BioreactorHiroshi Mizumoto

105Microchip Culture of Embryoid Bodies from Mouse ES CellsKohji Nakazawa

106Development of a Tissue EngineeredEx Vivo Mammalian Lung Model Using Endogenous Lung orEmbryonic Stem CellsJoan Nichols

107Opposite Function of Leukotrine B4 Receptors on Proliferation of Mesenchymal Stem CellsSeung Yeon Park

108Progress in Genetic Reprogrammingof Adipose-Derived MesenchymalStem Cells Towards an HepatocyteLineageHoward I. Pryor II

109Discrepancies Between Metabolic and DNA Assays Assessing Cell ProliferationVerena Quent

110Effect of Epidermal Growth Factor(EGF) and Basic Fibroblast GrowthFactor (bFGF) on Connective TissueProgenitor Cells from Human BoneMarrow Primary CultureVivek Raut

111Substitution of Fetal Calf Serum by Platelet Lysate for the Expansion of Stem Cells Derived from AdiposeTissue and Amniotic MembraneHeinz Redl

1122D and 3D Multi-Lineage Cell Co-Culture for Vascularized Bone EngineeringDerek Reformat

113Growth Attenuation of Cancer Initiating Stem Cells by Doxorubicin-Conjugated Quantum DotsBhranti Shah

114A Novel Filtration System for thePreparation of MSC Progenitors from Human Bone MarrowMartin Smith

115Aged Adipose Derived Stem Cells are More Proliferative and LessResponsive to Differentiation CuesMatthew Stern

116Migration and Gene Expression ofChemokine-induced MSC for In SituTissue Regeneration ApplicationsStefan Stich

117A Role for Shear Stress in VenousVersus Arterial Specification fromVascular Progenitor CellsSarah Stolberg

118Adipose-derived Stem CellsDifferentiate Towards Two VascularSubpopulations in PEGylated FibrinLaura Suggs

119Membrane Potential is a DeterminingFactor for Human Mesenchymal Stem Cell DifferentiationSarah Sundelacruz

120Pluripotent Embryonic Stem Cells arePrevalent in Bioreactor DifferentiationsJaymi Taiani

121In Vivo SDF-1a (CXCL12) MediatedMSC Recruitment to TissueEngineering ScaffoldsPaul Thevenot

122Differentiation of Human Bone Marrow Stem Cells into Smooth Muscle for Urinary Tract ReconstructionHong Tian

123Transcriptional Profiling and MatrixMineralization Assessment of Osteo-genically Stimulated Human StemCells from Three Different SourcesMatthew Tomlinson

124The Effect of Low Oxygen on Cultureof Mouse and Human MesenchymalProgenitor Cells from Bone MarrowRavenska Wagey

125Role of Cellular Interactions in Stem Cell-Mediated Regeneration of the Soft Tissue-to-Bone InterfaceI-Ning Wang

126Amniotic Fluid-Derived Stem Cellsfrom Nonhuman Primates:Implications for Muscle RegenerationKoudy Williams

127Wnt/beta-catenin Signaling InhibitsProliferation but Enhances MyogenicDifferentiation of Skeletal Muscle-derived Stem CellsGuosheng Xiang

Synthetic and Biologic Scaffolds

128Strengthening Chitosan-Based Aortic Valve Scaffolds with ThiolatedChitosan Fibers: MechanicalProperties & Cell InteractionsMohammad Albanna

129Amino Alcohol-based ElastomericPoly(ester amide)s for Hepatic Tissue EngineeringChristopher Bettinger

130Constructive Bioscaffold Remodelingis Inhibited by Long-TermCatheterization in a Canine PartialCystectomy ModelAlan Boruch

131Surface Characterization of Biologic Scaffolds Composed of Extracellular MatrixBryan Brown

132Optimisation of Primary HumanOsteoblast Culture on Novel CollagenHydroxyapatite ScaffoldsSarah Cartmell

1333D Scaffolds for Enhanced CellCulture and Tissue EngineeringApplicationsRobert Chang

134Modelling of Time-Dependent ElasticProperties of Tissue ScaffoldsDaniel Chen

135Characteristics of Fibrin ScaffoldsPredicted from Darcy’s Law and Dextran Molecular Probes Over Varying Concentrations of Fibrinogen and Thrombin Cecilia Chiu

136Microchannel Generation by SelectiveDegradation of Patterned Hydrogels Yu-Chieh Chiu

137Development of Nano-MatrixComposed of Polyethylenimine andPoly(Â-caprolactone) for GeneDelivery and Tissue EngineeringJongHoon Chung

138Fluorescence Unravelling the Fate of Scaffolds: Real-time Monitoring of Scaffold Degradation In Vitro and In Vivo Cassilda Cunha-Reis

139Modulation of 3-Dimensional FibrinMatrix Stiffness by Intrinsic Fibrinogen-Thrombin Compositions and by Extrinsic Cellular ActivityHaison Duong

140The Molecular Design of PLGAfor Phase Inversion ScaffoldsMarianne Ellis

141Human Tissue Allograft Processing’s:Impact On In Vitro And In VivoBiocompatibilityShalaw Fawzi Mohammed

142Hydrated Xenogeneic DecellularizedTracheal Matrix as a Scaffold for Tracheal ReconstructionThomas Gilbert

143Biomimetic Hydrogel Scaffolds for Tissue Engineering Made by Protein–Polymer Conjugation and PhotopolymerizationMaya Gonen-Wadmany

144Porcine Abdominal Wall Fascia as an Alternative ECM SourceKatie Harrigan

145Longterm Stability of Artificial Cornea Implants based on NovelInterpenetrating NetworksLaura Hartmann

146The Effects of Crosslinking on Mechanical Properties and Osteoblast Activity within Collagen-GAG ScaffoldsMatthew Haugh

147Reduction of Fibrinolysis in FibrinSealants: Different Approaches and Their EffectivenessHans Christian Hedrich

148Synthesis, Processing andCharacterization of a Biodegradable, ElastomericPoly(ester-carbonate urethane) Urea (PECUU) for Soft Tissue EngineeringYi Hong

149Effect of Ipriflavone Loaded PLGA Microsphere and Bone Marrow-derived Stem Cells on theOsteogenic Differentiation for Tissue Engineered BoneHee Kyung Hong

20 21


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150Mechanical, Permeability, and Degradation Properties of 3D Designed Poly(1,8 Octanediol-co-Citrate) Scaffolds for Cartilage Tissue EngineeringClaire Jeong

151Muscle Extracellular Matrix as aScaffold for Adipose DerivedMesenchymal Stem CellsJoanna Johnson

152A Computational Model for Hydrolytic Degradation of Porous Polymer ScaffoldsHeesuk Kang

153A Collagen/PLGA Hybrid ScaffoldHaving High Cell Seeding Efficiencyand Mechanical StrengthNaoki Kawazoe

154Tailoring the Tangent Modulos of 3D-designed Poly(Glycerol Sebacate)Scaffolds for Cartilage ApplicationsJessica Kemppainen

155The Effects of Scaffold Permeabilityon Chondrogenesis Using Chondro-cytes or Bone Marrow Stromal CellsJessica Kemppainen

156Decellularization of Porcine Cornea by Ulta-high Pressurization and In Vivo StudyAkio Kishida

157Self-Assembling Peptide HydrogelsEnhance MSC Proliferation andAccumulation of a Cartilage-Like ECMPaul Kopesky

158Integrated Dual Scaffolding System for the Engineering of Muscle-TendonJunctionMitchell Ladd

159Development of Connected PEG Microsphere Scaffolds forTissue-Engineering ApplicationsJeffery Larson

160Osteogenic differentiation of hMSCson Poly(lactic-co-glycolic acid) andHydroxyapatite Composite NanofibersJi-hye Lee

161Thermal Treatment Enhances Physical Properties of ElectrospunPolycaprolactone ScaffoldsSang Jin Lee

162Engineered Cartilage Covered EarImplants for Auricular ReconstructionSang Jin Lee

163Controlled Release of BMP-2 fromInjectable Polyurethane ScaffoldsBing Li

164Bone Regeneration Using HyaluronicAcid-based Temperature-responsiveChitosan-g-poly(N- isopropylacry-lamide) Hydrogel and MesenchymalStem CellsHan Tsung Liao

165Effect of Controlled Release of Bone Morphogenetic Proteins-2 from Bi-phase Alginate Carriers onOsteoblastic Differentiation of Bone Marrow Stromal CellsHyunju Lim

166Glucagon-Like Peptide-1 ImmobilizedBioactive PEG Hydrogels to Promote Cell FunctionChien-Chi Lin

167In Vitro and In Vivo Characterization of the Foreign Body Response toPoly(Ethylene Glycol) BasedHydrogelsAaron Lynn

168Mechano-compatible Collagen-basedScaffolds for Vascular TissueEngineering: Low Doses of UV Affect the Viscoelastic BehaviourDiego Mantovani

169Decellularized Human MyocardiumRetains Structural and MechanicalProperties of Native Myocardium and is Well Tolerated In VivoTimothy Martens

170Reproducing Native VesselArchitecture: Multilayered ElectrospunSmall Diameter Vascular GraftsMichael McClure

171Inverted Human Umbilical Arteries with Tunable Wall Thicknesses for Nerve RegenerationPeter McFetridge

172Characterization of SWNT Compositefor Tissue Engineering ApplicationsPeter McFetridge

173Cross-Linking Density of a Photo-polymerizable Hydrogel ScaffoldAffects Cell Viability and MorphologyIris Mironi-Harpaz

174Effects of Pore Geometry and Material on In Vivo Bone Ingrowth in Designed PCL, PPF and PPF-TCP ScaffoldsErin Moffitt

175Ex Vivo Cord Blood Expansion UsingPolymeric Scaffolds Without theAddition of External Growth FactorsTeresa Mortera Blanco

176Surface-modification of anElectrospun Elastomeric ScaffoldImproves Patency Rates when Usedas a Small Diameter Vascular Graft in a Rat ModelAlejandro Nieponice

177Genetically Engineered Silk for Improved Cell AdhesionAlex Nilsson

178A Biomimetic Hydrogel ScaffoldMaterial with Affinity-Based ControlledDrug Delivery for Tissue RegenerationLiat Oss-Ronen

179Tissue Engineered Trachea UsingDecellularized AortaAna Paz

180Comparison of Soluble and InsolubleCalcium Phosphate Scaffolds for Bone Tissue Engineering ApplicationsJenni R. Popp

181Characterization of Fibrin Matrix for Tissue Engineering ApproachesUsing Human ASCHeinz Redl

182A Nondestructive Method to PredictElastic and Yield Properties of Fabricated Porous Scaffolds Using Micro-CT and an Image Based Finite Element AnalysisEiji Saito

183Photo-Crosslinked Foams of NaturalExtracellular Matrix Proteins as NovelScaffolds for Tissue EngineeringLillian Sando

184Protein Tethering and Cell Growth on Surface-modified InterpenetratingPolymer Double Network Hydrogelsfor Artificial Cornea ApplicationsAlaina Schlinker

185Preliminary Investigation of AdiposeDerived Stem Cells and ElectrospunScaffolds for Ligament EngineeringScott Sell

186Migration of Cocultured Osteoblastson Biphasic Hydroxyapatite/Poly (L-Lactic) Acid ScaffoldsAmita Shah

187Differentiation of Adipose DerivedStem Cells on Trabecular CalciumPhosphate ScaffoldsArlene Siller-Jackson

188Extracel(TM)-Coated Microbeads forCell Cluster Culture and RecoveryAleksander Skardal

189Characterizing the Incorporation of Biological Signals in Poly(ethyleneglycol) Diacrylate (PEGDA) HydrogelsMichael Turturro

190Tissue-Derived Hydrogels SupportAdipogenesis In Vitro and In VivoShiri Uriel

191Functionalized PolycaprolactoneNanofiber Scaffolds for PeripheralNerve RegenerationChandra Valmikinathan

192Polycaprolactone and Bovine Serum Albumin Nanofibers for the Controlled Release of NerveGrowth FactorChandra Valmikinathan

193Controlling the Nanostructure of Collagen Scaffolds: FromMonomeric Solution to Fibrillar,Porous ScaffoldsRobin Walton

194Collagen Scaffolds: The Effects of Structure and Processing on Enzymatic DegradationRobin Walton

195Replicating the CornealMicrostructure Using ChondroitinSulfateRobert Warren

196Porous 3D Cellulose Fiber BasedMicroscaffold for Cell CultureQi Xing

197Investigation of ElectrospunComposite Scaffolds as a DeliveryMatrix for Traumatic Brain InjuryClark Zhang

198Innovative Biodegradable and Bioactive Biomaterials for Bone AugmentationHala Zreiqat

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Bioreactors and Mechanical Training of Tissue Constructs

1The Role of Dynamic Flow in Vascular Wall Remodeling in an Ex Vivo Bioreactor SystemOscar Abilez

2Longitudinal FunctionalCharacterization of In Vivo Rat Bladder RegenerationTamer Aboushwareb

3Osteoblast Response to EquibiaxialCyclic Tensile Stretching on HA/PEG Gels with GRGDS PeptidePedro Alvarez Urena

4The Differential Effect of ScaffoldComposition and Architecture on Chondrogenic Response to Mechanical StimulationTaly Appelman

5Effect of Uniaxial Cyclic Stretch on Ligament Progenitor Cells Seededon Electrospun Fibrous MeshesChristopher Bashur

6Strain Transduction in Cells Seededon a Scaffold Exposed to Uni-AxialStretching: A Three-Dimensional Finite Element StudyAmber Bonivtch

7Functionalized Microfluidic Networksfor Evaluation of Vascular InjuryJeffrey Borenstein

8Development of a Stable ArtificialOxygen Carrier for TissueEngineeringRussell Condie

9Silk Fibroin and Chitosan-ChondrocyteComposite for TrachealReconstructionGreg Davis

10Controlled Differentiation of hMSCs In Vitro and In Vivo Using MagneticNanoparticle TechnologyAlicia El Haj

11A Novel Tissue Engineered BloodVessel Bioreactor and HemodynamicPressure Profiles for Canine FemoralArteries and Silicone TubesAndrew Gassman

12Tissue Engineered Small-diameterBlood Vessel for Coronary ArteryBypass GraftingKiyotaka Iwasaki

13Novel Action of Biphasic ElectricCurrent In Vitro Osteogenesis of Human Bone Marrow Mesenchymal Stromal Cells Coupled with VEGF ProductionIn Sook Kim

14The Effect of Strain on Rabbit CornealFibroblasts: Cell Phenotype andBioreactor CharacterizationJanet Komatsu

15Engineering of Artificial Skin UsingProcessed Allogenic Dermis(Sheba™) as a Dermal Scaffold Jung Hee Lee

16Umbilical Cord Blood HematopoieticStem/Progenitor Cell ExpansionSupported by MicroencapsulatedOsteoblasts Tianqing Liu

17Coculture of Hematopoietic Stem Cells and Mesenchymal Stem CellsDerived from Umbilical Cord BloodTianqing Liu

18Optimization of A Natural CollagenScaffold for Cell Growth and Matrix Penetration in Urological Tissue EngineeringYan Liu

19How to Optimise the MaturationConditions in a Bioreactor? Toward an Intelligent Bioreactor for Vascular Tissue EngineeringDiego Mantovani

20Quantitative Design Analysis of aModular Tissue-Engineered ConstructAlison McGuigan

21Real-time Monitoring of ForceResponse Measured in MechanicallyStimulated Tissue EngineeringCartilageJoseph Mizrahi

22Differential Regulation of BMPs on Chondrocytes and Osteoblasts in Osteochondral Constructs by Biomechanical ForcesJin Nam

23Controlling Anabolic and CatabolicProcesses Through MechanicalStimulation of ChondrocytesGarret Nicodemus

24Effects of Sinusoidal CompressiveLoading for MC2T2-E1 CellsJeong Hun Park

25Tissue Engineering of the ACL;Degradable Glass Fibre/PCLCompositesSarah Rathbone

26A Combined Theoretical-experimentalParadigm for Studying Mechanically-mediated Growth, Remodeling,Damage, and Plasticity of Gel-derivedTissue Engineered Blood VesselsJulia Raykin

27Controlled Microcarrier BasedCultivation of Adherent MesenchymalCells in a Stirring ReactorJochen Ringe

28Design and Validation of a 3D Tissue Manufacturing System:The Dynamic Triaxial BioreactorImmanuel Sebastine

29Ex Vivo Expansion of Human Cord Blood (hCB) Stem Cells Encapsulated in Hydrogels in the NovaPod BioreactorKedong Song

Cardiovascular and Vascular Tissue Engineering

30Enhanced In Vivo Endothelialisation of Allogenic Detergent DecellularizedHeart Valves by Surface CoatingUsing Autologous FibrinPayam Akhyari

31Impact of Coating by Different Proteins on the Re-endothelializationof Biological Heart Valve ScaffoldsPayam Akhyari

32Human Circulating Progenitor Cellsand Poly(diol citrates): A NewApproach to Improve ProstheticVascular GraftsGuillermo Ameer

33Heterogeneous Tissue ConstructGeneration by Concurrent PolymerElectrospinning and CellElectrosprayingNicholas Amoroso

34Development of a BiochemicallyFunctionalized, Silk-Based Vascular GraftCassandra Baughman

35Implementation of ImprovedPhysiologic Components in an In Vitro Tissue Engineered BloodVessel Mimic for Stent EvaluationKristen Cardinal

36Clinically Relevant Methods for In Situ Vascular EngineeringScott Collins

37Adsorbed Native Cardiac ExtracellularMatrix Coating for the Culture of CardiomyocytesJessica DeQuach

38A Novel Vascular Co-culture Modelwith a Biomimetic Internal ElasticLaminaEric Finkelstein

39Impact of Matrix Injury on InducedElastin Matrix RegenerationCarmen Gacchina

40Evaluation of Angiogenic Activity in Human Macrophages onElectrospun Vascular graftsKoyal Garg

41Tissue Engineered Vascular Adventitia with Vasa Vasorum(TEVAwVV) : Impact of Vascular-ization and Implantation on theMechanical PropertiesRobert Gauvin

42Patency and Tissue Integrity ofArterial Xenografts Implanted for 6 Months as Carotid Artery Grafts in SheepAlbert Grobe

43Polymer Films with Pore-size-controlled Honeycomb-PatternAffects on Proliferation, Apoptosisand Differentiation of Rat Vascular Smooth Muscle CellsManabu Haga

44In-Vitro Assessment of a HumanPericyte-Based Tissue-EngineeredVascular GraftWei He

45Sacrificial Microfiber Networks:Towards the Fabrication ofVascularized Tissue ConstructsPeter Henderson

46The Role of Bone MarrowMononuclear Cell Seeding for theDevelopment of a Small DiameterTissue Engineered Vascular GraftNarutoshi Hibino

47Small Diameter In Vitro Vascular ModelDavid Hoganson

48Fluid-Solid-Interaction of the AorticValve: The Effect of NonlinearMaterial Properties and Aortic Root DilationAkram Joda

49A Macrophage Assay to Identify theInnate Pro-Inflammatory Capacity ofBioengineered Vascular ConstructsAra Ketchedjian

50The Bioabsorbable Materials with Phosphorylcholine Group-richSurfaces for Temporary Scaffolding of the Vessel WallHyung Il Kim

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POSTER SESSION II • Tuesday, December 8, 2008 • 5:30 - 6:30 pm

Endocrine and Metabolic Tissue Engineering

91Ultrastructure of Organ-specificExtracellular Matrix in TissueEngineering of Endocrine OrgansDarelle Dogans

92Diabetes Correction by Monolayer PigIslets Device in Non-Human PrimatesDenis Dufrane

93Improved Viability of Tissue-engineered Islets Co-cultured with Chondrocyte MatrixSamuel Galvagno

94The Optimisation of Statins to Increase Mineralisation of PrimaryHuman Osteoblasts for Bone Tissue Engineered Constructs Sarah Griffiths

95Engineering Functional Islets from Cultured CellsShohta Kodama

96Novel RAGE Bioadsorbent InhibitsBeta-amyloid-induced InflammatoryActivation of Endothelial CellsKaren Lapidos

97Suramin, P2-Receptors Antagonist,Blocks Cell-cell Propagation of aSignal Induced by MechanicalStimulation of a Single OsteoclastOsama Maria

98Collagen Type1 Promotes Embryonic Pancreatic Precursor Cell Differentiation into Glucose-responsive Beta-cells in PEG Hydrogel CulturesMariah Mason

99Cryopreservation Effects on a Model Pancreatic SubstituteAthanassios Sambanis

51Patterned Channels in PEGHydrogels for Cardiac Muscle Tissue EngineeringStephanie LaNasa

52Fabrication of Scaffold thatWithstands Physiological Vascular ConditionsSang Jin Lee

53Fabrication and Characterization of a Cardiac Construct Using the Modular ApproachBrendan Leung

54Engineering Vascularized CardiacMuscle Tissue From HumanEmbryonic Stem CellsShulamit Levenberg

55Prevention of Inflammation, Extra-cellular Matrix Alternation, and TissueCalcification by Decellularization of Pulmonary AllograftsArtur Lichtenberg

56Hair Follicle is a Novel Source of Mesenchymal Stem Cells for Tissue EngineeringJin Yu Liu

57Development of the Human UmbilicalArtery (HUA) as a Three DimensionalScaffold for Vascular ReconstructionPeter McFetridge

58Improved Endothelial Differentiation of Adipose Derived Stem Cells AfterTransfection with eNOSStephen McIlhenny

59Using a Small Animal Model toElucidate the Role of Monocytes in the Development of Tissue-Engineered Vascular GraftsTamar Mirensky

60Nonlinear Elastic and CardiacMyocyte Force GenerationCharacteristics of Poly(glycerol sebacate)Anna Mitsak

61Extended View and Quantification of Collagen Scaffold Remodeling by Smooth Muscle CellsYonggang Pang

62Elastin Production in 3-D FibrinConstructs is Up-Regulated byHyaluronan Oligomers and TGF-b1Erin Pardue

63Aligned Electrospun PolyurethaneScaffolds Leads to AnisotropicOrganization of Embryonic Stem Cell-derived Cardiomyocytes andFibroblasts that Mimic Cardiac TissueIan Parrag

64Properties of Tissue Engineered Heart Valves After Mechanical Pre-Conditioning at Pulmonary ArteryHemodynamic ConditionsSharan Ramaswamy

65Development of a Chitosan Fiber-Reinforced, Large Vessel Graftfor Pediatric ApplicationsIrina Robu

66Transplanted Human Cord BloodDerived Unrestricted Somatic StemCells Improve Left-VentricularFunction And Prevent Left-VentricularDilation And Scar Formation AfterAcute Myocardial InfarctionArjang Ruhparwar

67In Vitro Blood Compatibility Studies of Tissue Engineered Small DiameterVascular GraftsAsha Mathew

68Effects of Particulate Integration on the Structure and MechanicalAnisotropy of Electrospun ConstructsMichael Sacks

69Applying Cyclic Strain After HydrogelCompaction Improves TissueEngineered Vascular Media FunctionStacey Schutte

70A Biocompatible Fibrin-basedHydrogel for Cardiac Cell Therapy and Tissue EngineeringKeren Shapira-Schweitzer

71Penta-galloylglucose-stabilizedAcellular Scaffolds for TissueEngineered Heart ValvesAgneta Simionescu

72An Injectable Scaffold for MyocardialTissue Engineering Derived fromNative Cardiac Extracellular MatrixJennifer Singelyn

73Optimized TGF-b Dosing to MaximizeCollagen and Elastin DepositionDuring Cyclic StretchingZeeshan Syedain

74Regeneration of Artery by UsingBiological Grafts Derived from Aortic TissueDohiko Terada

75In Vivo Assessment of ElectrospunVascular Scaffolds: A Feasibility StudyBryan Tillman

76Evaluation of NanoparticleImpregnated Tissue EngineeredBiodegradable Polymer ScaffoldsRagaseema Valsala Madhavan

77Cardiomyocyte Seeding of an Intact Decellularized Rat HeartJohn Wainwright

78Confluent, Aligned Cell Sheets Grownon Thermo-Responsive Substrates for Building Structured TissuesCorin Williams

79Tissue Engineered Endothelial and Epithelial Implants Differentiallyand Synergistically Regulate Airway RepairBrett Zani

80Silk-Based Tissue-EngineeredVascular Graft through DynamicCulture ConditionsXiaohui Zhang

Craniofacial and Dental Tissue Engineering

81Engineered Trachea for SegmentalDefect Repair in RabbitsJames Dennis

82Long-term In Vitro Cultivation of Anatomically-shaped Bone GraftsWarren Grayson

83Comparative Study of Platelet-RichPlasma (PRP) and Bone MarrowAspirate for Bone Regeneration in Rabbit Alveolar Cleft ModelTae Jung Kim

84Combination of Guided Osteogenesiswith Injectable Autologous Platelet-rich Fibrin Glue (PRFG) and Mesenchymal Stem Cell forReconstruction of Mandibular DefectsHan Tsung Liao

85Biomechanical Behavior of PorcineSoft Oral Tissues for TissueEngineering ApplicationsPeter McFetridge

86In Vivo Dentofacial TissueEngineeringNeal C. Murphy

87A Bioengineered PCL Scaffold for TMJ Tissue RepairSubhra Nag

88AMD3100 Enhances Bony Healing Via Improved Neovascularization and OsteogenesisXiaoxia Wang

89Engineering Cartilage with HumanNasal Alar Shape by Using Cell-macroaggregate TechniqueWei Wu

90The Construction of Ear-shapedCartilage: In Vitro and In Vivo StudiesLu Zhang

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107Bioinformatic Analysis of OsteogenicBMPs Gives Insight into InhibitoryActivity of BMP3Karl Balch

108Human Osteoblast Adhesion to Thermally Oxidized Gamma TiAl SurfacesSamir A. Bello

109Sphingosine 1-Phosphate Receptor-Selective ActivationEnhances Bone RegenerationEdward Botchwey

110Biodegradable Polyol-based Polymers for Musculoskeletal Tissue EngineeringJoost Bruggeman

111Osteoblast: Osteoclast Co-CulturesSilk Fibroin Films And SpongesSarah Cartmell

112Organized Nanofibers FacilitateAlignment of MyotubesJin San Choi

113A Novel Poly(e-Caprolactone)Invertebral Cage for Anterior Cervical Discectomy and Fusion in a Porcine ModelColleen Flanagan

114Tissue-Derived Collagen Scaffold for Skeletal Muscle CellsToshia Fujisato

115Injectable Engineered Stem CellsInduce Mechanically Rigid Posterior Spine FusionDan Gazit

116Investigation of Statin Mechanisms of Action on Primary HumanOsteoblasts through TemporalMicroarray Analysis – for the Use of Statin’s to Enhance Bone TissueEngineered ConstructsSarah Griffiths

117Injectable, BiodegradablePolyurethane Scaffolds with LocalLovastatin Delivery for EnhancedBone RegenerationAndrea Hafeman

118Injectable Hyaluronan Gels FormsBone In-VivoJöns Hilborn

119Bone Regeneration in CraniofacialDefects Compromised RadiationDamage Can be Improved by In Situ Gene TherapyWei-Wen Hu

120In Vitro Calcification of ImmatureArticular Cartilage to Form a Func-tional Zone of Calcified CartilageJennifer Hwang

121Aligned Nanofibrous MulticomponentScaffolds for Bone Tissue EngineeringMoncy Jose

122Efficient Articular Cartilage Regeneration Without CellTransplantation: Use of Microfracture and Hyaluronic AcidByung-Soo Kim

123Quantitative Zonal Distribution of Glycosaminoglycans in Human,Bovine, and Ovine Articular CartilageTravis Klein

124Chitosan Microparticles as Protein Carriers for Cartilage Tissue EngineeringMin Lee

125Biomimetic Apatite-CoatedAlginate/Chitosan Microparticles as Osteogenic Protein CarriersMin Lee

126Dual Mineralization Strategies forBone Tissue Engineering ScaffoldsParthasarathy Madurantakam

127Differences Between Zonal EquineCartilage Cell Populations During In Vitro CultureJos Malda

128Molecular Identification of PhenotypeCharacteristics in ChondrocytesCultured in Two Dimensions and Cell Pellet CulturesMaría Masri

129Tissue Engineered Bone Grafts Using Adipose-Derived Stem Cells and Perfusion BioreactorMirjam Frohlich

130The Effect of PolycaprolactoneScaffold Permeability on Bone Growth In VivoAnna Mitsak

131Novel Water Dispersible CarbonNanotube Composite Scaffolds for Bone Tissue EngineeringSyam Prasad Nukavarapu

132Effects of Temperature and Serum on Storage of Fresh GoatOsteochondral GraftsAndrea Pallante

133The Effects of Intermittent HydrostaticPressure on M2-10B4 Cells in Co-Culturing SystemSo Hee Park

134Microstructural Finite Element Modeland Computed Tomography Analysisof Non Union Fracture Repaired ByEngineered Mesenchymal Stem CellsGadi Pelled

135Effects of Perfusion Flow on hMSC Construct Development in Chitosan-Based Biomimetic 3-D ScaffoldsKatelyn Sellgren

136Histogenesis by Nucleus PulposusCells in Type II Collagen Versus TypeII Collagen-GAG Scaffolds In VitroKristy Shine

137Allograft Derived MeniscusBioscaffold: Characterization and SeedingJulie Steen

138The Development of Biomaterials from Porcine Skeletal MuscleExtracellular MatrixMatthew Stern

139Engineered Skeletal Muscle MyooidsCathryn Sundback

140Restoration of MusculotendinousTissue Following Massive SurgicalExcision in a Canine ModelNeill Turner

141The Effect of Fiber Layer Thickness on the Bioactivity of Nanofibrous 3D Scaffolds for Bone Tissue EngineeringJunping Wang

Nanotechnology for Tissue Engineering

142Alginate Based Nanoparticles as a Temporary Red Blood CellSubstituteElvin Lee

143Biomimetic Nanofiber Scaffolds forEfficient Adhesion of MesenchymalStem Cell in Skin Graft ApplicationKun Ma

144Mineralization of Peptide AmphiphileNanofibers and their Effect on theDifferentiation of hMSCsTimothy Sargeant

145Cell and Tissue Organization andAdhesion at Titanium DioxideNanotube InterfacesGarrett Smith

146An Ultra-Porous NanofibrousScaffold Enables Creation of 3D Structures by HumanEmbryonic Stem CellsRoey Tzezana

147Novel Magnetic-hydroxyapatiteNanoparticles for Non-viral Gene DeliveryHsi-Chin Wu

148Influence of Micro- andNanotopography on Bovine CorneaEndothelial CellsEvelyn Yim

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Gene Therapy and Tissue Engineering

100Scaffold-mediated Transfection of Human Mesenchymal Stem Cellsby Chitosan-DNA NanoparticlesKimberly Hunter

101Effect of Condensed DNA by Ultra-high Hydrostatic Pressurizationon In Vivo Gene TransfectionTsuyoshi Kimura

Musculoskeletal Tissue Engineering

102Characterization ofPLGA/Demineralized Bone Particle as Composites Scaffold for ArticularCartilage RegenerationSik Il Ahn

103Chondrogenic Differentiations of Adipose Tissue-derived Mesenchymal Stem CellsJi Hyun Ahn

104ERK1/2 Inhibitor EnhancesChondrogenesisJi Hyun Ahn

105In Vivo Evaluation of NovelMineralized Collagen ScaffoldsAmir Al-Munajjed

106Controlled Bupivacaine Delivery from Citric Acid-based CompositesGuillermo Ameer

157Neural Precursor Cells (NPCs) Form Mature Neural Tissue When Cultured Within Bioinert 3D Poly(ethylene)glycol (PEG) HydrogelsRachael Namba

158Neuronal Differentiation of RatBMSCs on Keratin/PLGA ScaffoldJong Hak Park

159Multifunctional Agarose HydrogelScaffolds for Nerve RepairJeff Sakamoto

160Keratin Biomaterials Show aStructural Dependence on Schwann Cell ActivationPaulina Sierpinski

161Nanofiber Coated Spiral Scaffolds for Nerve Tissue EngineeringChandra Valmikinathan

Organ Tissue Engineering

162Organ Engineering with Hepatic ECMStephen Badylak

163Engineering a Complex Organ: Tissue Engineered Lung using SSEA+ Oct-4+, CD133+, CD117+,ABCG2+ Endogenous LungProgenitor CellsJoaquin Cortiella

164Engineered Cardiac OrganoidChambers for Studying VentricularFunction, Injury, and RepairKevin Costa

Neural Tissue Engineering

149The In Vitro Development of a NovelMicroparticle-based Scaffold for Regenerative MedicineKapil Agashi

150Development of a Scaffold-less 3D Nerve Construct From RatFibroblast and Fetal Nerve CellsJennifer Baltich

151Evaluation of Axon Guidance by 2-Dimensional Binary MaterialsPatternsDaniel Chen

152Tissue Engineering MammalianNeuromuscular Junction: A DefinedModel SystemJames Hickman

153Stem and Progenitor Cells as Trophic Mediators of Axonal Growth in a Novel Peripheral Nerve ConduitWesley Jackson

154Effect of Keratin Content onAttachment and Phenotypical Stabilityof Olfactory Ensheathing Cell on Keratin/PLGA FilmNa Ri Jeon

155Olfactory Ensheathing Cells SecreteNeurotrophic Factors that May Have Applications in the Treatment of Spinal Cord InjuryHelder Marcal

156The Assessment of Novel CompositeMatrices for a Cell Delivery Device to Treat Traumatic Brain InjuryKacy McKibben

165Spontaneous 3D Organization and Enhanced Function of Liver CellsCultured onto 3D Micro-structuredPDMS Surfaces Under High Oxygen SupplyFanny Evenou

166Radial Design Vascular Network for Creation of a Tissue EngineeredLiver ScaffoldDavid Hoganson

167Development of a High DensityBiomimetic Vascular Network for aTissue Engineered Lung ScaffoldDavid Hoganson

168Platelet Adhesion is Minimized in Biomimetic Vascular NetworkDavid Hoganson

169Regular Alignment of Endothelial Cells Within Tissue Using EndothelialCell-covered HeterospheroidsMasakazu Inamori

170Extracellular Matrix Powder Attenuates Bleomycin-inducedPulmonary FibrosisMichelle Manni

171Enhanced Function and 3D Organization of Liver Tissue fromHepatocyte Progenitor Cells on HighlyOxygen Permeable MembraneHamon Morgan

172Bio Rapid Prototyping Project:A Simple Method to Build Living 3D Micro Patterned Cell ConstructWithout ScaffoldKoichi Nakayama

173Development of an In Vitro Liver Disease ModelCraig Neville

174Scale Dependent Kinematics of Fibrous Elastomeric Scaffolds for Tissue EngineeringJohn Stella

175Recreating the Corneal MicrostructureUsing Cell Sheet EngineeringStacy Sun

176Effects of Perfluorocarbon-basedArtificial Oxygen Carriers on TissueEngineered Trachea ConstructionQiang Tan

177Preparation and Evaluation of Surface-modified Poly(DL-lactide-co-glycolide) Scaffolds with GalactoseSu Jung You

Product Development and Commercialization of Tissue Engineering

178Human Cell Culture ProcessCapability: A Comparison of Manualand Automated ProductionYang Liu

179Automated Culture of EndothelialProgenitors Derived from Mono-nuclear Cells of Human PeripheralBlood and Bone MarrowYang Liu

180Evaluation of Airtransported CellSheets Fabricated with Temperature-Responsive Culture Surfaces Using a Portable Homothermal Containerand Sealing ApparatusTakayuki Nozaki

Tissue Engineering and Regenerative Medicine in the Clinic

181The Development of BioadhesiveMicroparticles for Clinical andRegenerative Medical ApplicationsDavid Chau

182Production of Hematopoietic Cells from Mouse Embryonic Stem Cells (ESCs) Using the HepG2-conditioned MediumIliana Fauzi

183Enhancement of Human Urine-derived Cell Proliferation andDifferentiation with Tissue-specificExtra-cellular Matrix CoatingsYujiang He

184Optimization of Porcine LiverExtracellular Matrix Coating for Hep G2 Cell Growth andDifferentiation In VitroYujiang He

185Tissue-specific Extra-cellular Matrix Coatings for Cell Proliferationand DifferentiationYujiang He

186Optimization of a Natural CollagenScaffold in Cell-matrix Penetration for Urological Tissue EngineeringYan Liu

187Human Dental Pulp Stem Cells as a Potential Alternative Source forCorneal Epithelium ReconstuctionBábyla Monteiro

188Primary Hepatocyte SandwichPerfusion Culture Based on Micro-fabricated Silicon Nitride MembranesShufang Zhang

Transplantation, Immunology and Cancer

189Physical Conditioning of CartilageExplants Requires RAS Activation for ERK MAP Kinases MediatedVEGF and Aggrecan Expression in Articular ChondrocytesSudha Agarwal

190Time Course of Cell Sheet Adhesion Onto Pig’s Heart After TransplantationDehua Chang

191Human Tissue AllograftProcessing’s: Impact on In Vitro and In Vivo BiocompatibilityShalaw Fawzi Mohammed

192Tumor-derived Endothelial CellsExhibit Aberrant Rho-mediatedMechanosensing and AbnormalAngiogenesis In VitroKaustabh Ghosh

193Limb Tissue Regeneration: A Proteomics Profile of theRegenerating BlastemaHelder Marcal

194Tissue Engineering Model for Breast Cancer Metastasis to BoneMichaela Reagan

195Acquired and Innate ImmuneResponses In Vitro to ElectrospunPolydioxanone-elastin BlendsMatthew Smith

196In Vitro Immune Response Testing of Electrospun Polydioxanone and Collagen BlendsMatthew Smith

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Dear Students, Young Investigators, and Conference Attendees,

Welcome to San Diego and thank you for joining us at TERMIS-NA 2008!The TERMIS Student and Young Investigator Section North America (SYIS-NA) Meeting Committee has prepared a special program for students and post-docs to fostercareer development and encourage networking and interaction with experts in the field.We hope you enjoy our program and find it stimulating!

The SYIS program opens on Sunday evening with a Student Welcome Area atthe TERMIS-NA Conference Welcome Reception. Please stop by to introduce yourself,find out more about SYIS, become a SYIS member, and sign up for SYIS events!

SYIS events on Monday December 8th focus on professional and career development. The morning and afternoon Resume and Job Search Workshops will givetips from academia and industry insiders on how to make the job application processeasier. The Panel Discussion on Career Paths in Tissue Engineering and RegenerativeMedicine will be a Q&A discussion of academia and industry paths taken by currentleaders in the field.

SYIS events on Tuesday December 9th focus on helping students develop interactions with experts in the field. The day begins with a 5K Fun Run that will tour the nearby University of California, San Diego campus. The Student-Meet-Mentor Lunchis a highlight of the SYIS program, and will give 80 SYIS members the opportunity to enjoy a plated lunch with 19 mentors, with seating arranged by student preference(advance signups required).

SYIS is also excited to coordinate the SYIS Poster Competition. The top 19young investigator posters (authors were notified prior to the conference) will be judgedby members from the Scientific Advisory Committee, with awards for 1st place ($500),2nd place ($300), and 3rd place ($200). Poster award winners will be announced on Wednesday prior to the Plenary Lecture at 8:00am.

We hope you have a fantastic TERMIS-NA Meeting and look forward to meeting you!

Allison Finger Jennifer HwangSYIS-NA Meeting Co-Chair SYIS-NA Meeting Co-Chair

SYIS Welcome Reception Sunday, December 7th

6:00-8:00 PMCome to the SYIS Welcome Area at the TERMIS-NA Conference WelcomeReception to meet students and younginvestigators from around the world who are attending the TERMIS-NAMeeting. Find out more about SYIS and sign up for SYIS events!

Resume WorkshopMonday, December 8th

9:30 – 10:00 AM • Portofino A & BLearn how to brush up that resume andtailor it to the job you want. A represen-tative from the University of California, San Diego Career Center will teach CV and resume writing techniques.

Panel Discussion: Career Paths in TE & RMMonday, December 8th

11:30 – 1:00 PM • Portofino A & BThe panel will be composed of onetenured academic professor, onefemale/minority professor, one CEO of a large company, one CEO of a smallcompany, and one panel member in anoutside field. Each panel member will be introduced, followed by questions from the moderator and the audience. This event will provide SYIS memberswith different perspectives from severalcareer paths that are open to them.

Job Search and Networking WorkshopMonday, December 8th

2:30 – 3:00 PM • Portofino A & BA good strategy for getting the job youwant includes good job searching andnetworking skills. Learn how to find your dream job and effectively present yourself to get it.

5K Fun RunTuesday, December 8th

7:00 – 8:00 AM • Meet outside the Hyatt Conference Hotel main entranceEnjoy a brisk morning jog with fellow conference-goers. The 5K route will tour

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TERMIS-NA Student & Young Investigator Section (SYIS)

the nearby University of California-SanDiego campus. Run/walkers of all speedsare welcome. Water will be provided.

Student-Meet-Mentor LunchTuesday, December 9th

11:30-1:00 PM • Portofino A & BThe Student Meet Mentor Lunch gives 80 SYIS members the opportunity toenjoy a plated lunch with 19 mentors,with seating arranged by student prefer-ence. Mentors include Session Chairs,members of the Scientific AdvisoryCommittee, and local industry leaders.Students and post-docs can view a short biography of each of the mentorsprior to the event and rank their seatingpreferences according to their own interests. Advanced sign-ups required.

SYIS Poster Competition, sponsored by BaxterJudging: Monday, Dec 8th & Tuesday,Dec 9th, 5:00-6:30 PM at Poster Sessions Awards: Wednesday, Dec 10th, 8:00 AMprior to the Plenary Lecture

The top 19 young investigator posters, as scored by the abstract reviewers(authors were notified prior to the conference), will be judged by membersfrom the Scientific Advisory Committee.SYIS Poster Competition posters willremain up for both Poster Sessions I andII. Awards for 1st place ($500), 2nd place($300), and 3rd place ($200) have beengenerously provided by Baxter and willbe announced on Wednesday prior to the Plenary Lecture.

SYIS-NA Business MeetingWednesday, December 10th

7:30 AM • Portofino A & BThe annual TERMIS SYIS-NA businessmeeting is open to all students and younginvestigators. Attend this meeting to learnmore how to get involved in SYIS!

2 0 0 8 P R O G R A M

Wake Forest Institute for Regenerative Medicine Young Investigator Award Winners

The Wake Forest Institute for Regenerative Medicine has inaugurated a YoungInvestigator Award for the 2008 TERMIS-NA Conference and Expo. This award wasdesigned to recognize outstanding achievements of young investigators in order to fostercareer development and encourage solutions to the problems of regenerative medicine.The award consists of a certificate, $2500 cash prize, and recognition at the 2008 TERMIS-NA Conference and Expo. We are pleased to announce this year’s winners:Alison McGuigan, Ph.D. and Kristen Moffat, M.S.

Dr. McGuigan received her Bachelor’s and Master’s Engineering Degreesfrom the University of Oxford. She completed her Ph.D. in ChemicalEngineering in the laboratory of Dr. Michael Sefton at the University of Toronto with a thesis entitled “Design and Fabrication of a VascularisedTissue Engineered Construct.” Following a post-doctoral fellowship at Harvard with Dr. George Whitesides, she is now completing a post-

doctoral fellowship in the department of pathology at Stanford University in the laboratoryof Dr. Jeff Axelrod. She recently accepted a faculty position at the University of Torontoin the Department of Chemical Engineering to begin in April, 2009

Kristen L. Moffat is a doctoral student in the Department of BiomedicalEngineering at Columbia University. She is currently pursuing interface tissue engineering research in the Biomaterials and Interface TissueEngineering Laboratory (BITEL) under the guidance of Dr. Helen H. Lu.Kristen graduated with college and university honors from CarnegieMellon University earning dual degrees in Biomedical Engineering andMaterials Science and Engineering. Her doctoral research has focused on elucidatingthe structure-function relationship of soft tissue-to-bone interfaces and developing novel scaffold systems for tendon-to-bone tissue engineering and integrative soft tissue repair. Kristen is also a recipient of an NSF GK-12 Graduate Teaching Fellowship at Columbia University.

Congratulation to Alison and Kristen!

Bioreactors and Mechanical Training of Tissue Constructs

1A Three Dimensional Perfused LiverBioreactor to Test IdiosyncraticHepatotoxicityAjit Dash

2Implementation of a Novel Multi-Chamber Bioreactor for a TissueEngineered Urethral WrapDonna Haworth

3Engineering Lung Epithelial Cells from Embryonic Stem Cells in 3D Rotating Bioreactor SystemSiti Ismail

4Effect of Perfusion Flow on theExpression of Osteogenic GrowthFactors by Mesenchymal Stem CellsKatherine Kavlock

5Lipase Promotes OsteogenicDifferentiation of Marrow StromalCells on SPCL Fiber Meshes UnderFlow Perfusion ConditionsAna Martins

6Design and Evaluation of a NewFlow-Stretch-Flexure Bioreactor for Mechanical Conditioning of Engineered Heart Valve Tissues in the Physiological RangeSharan Ramaswamy


7Microsphere-Mediated Delivery of Retinoic Acid to Embryoid BodiesInduces an Early Streak PhenotypeRichard Carpenedo

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STUDENT POSTER COMPETITION

8Physiologically Relevant HypoxiaEnhances PC12 Neurite OutgrowthKent Leach

9Effect of Frequency of Pulsatile Flowon Expression of Growth andDifferentiation Factors by OsteoblastsLindsay Sharp

10Employing Poly(ethylene glycol)Hydrogels for Three-DimensionalCulturing of Mammary Epithelial CellsMichael Weiss

Microvascularization and Angiogenesis

11Cell-Induced Alignment of Fibrin GelResults in Directed Endothelial CellSprouting from SpheroidsKristen Thatcher

Musculoskeletal Tissue Engineering

12Aligned and Differentiated SkeletalMuscle Tissues with ControllableArchitecture and FunctionWeining Bian

13Osteoblast Maturity DictatesResponse to Vascular EndothelialGrowth FactorGeorge Kirmizidis

14CD34+ and Mesenchymal ProgenitorCells for the Vascularization of Engineered TissuesEduardo Moioli

Organ Tissue Engineering

15Effects of Hemi-Joint Culture on Biological, Biomechanical, and Biochemical Properties of Articular CartilageWilliam McCarty

Product Development and Commercialization of Tissue Engineering

16Innovative Cell Lines that ResistsApoptosis for the Production of Recombinant Protein for Use in Tissue Engineering StrategiesNico Wanandy

Stem Cells (MSCs, adult stem cells, embryonic stem cells)

17Mechanical Preconditioning ImprovesMuscle Stem Cell Transplantation in Skeletal and Cardiac MuscleLauren Drowley

18Adipose Stromal Cell Feeders Modu-late Morphology and Gene Expressionof Human Embryonic Stem CellsDarja Marolt

Transplantation, Immunology and Cancer

19Construction a Novel 3-D Heterogeneous Culture Model of Breast Architecture and Function in Silk ScaffoldXiuli Wang

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Glycosan: Booth No. 31

Healionics: Booth No. 47

Histogen: Booth No. 30

IOP Publishing: Booth No. 45

Lifecore: Booth No. 29

Lonza: Booth No. 46

McGowan Institute: Booth No. 28

Mimesis: Booth No. 33

National Center for Reg Medicine:

Booth No. 58

StemSoft: Booth No. 34

TissueGnostics: Booth No. 40

Tissue Growth Tech: Booth No. 25

Wake Forest: Booth No. 43

Biolog specializes in technology that characterizes microbial and mammalian cellular phenotypes.Phenotype MicroArrays use metabolite utilization and chemosensitivity assays to generate a unique fingerprint with 1000+ different cell-based phenotypes forany cell type. Key applicationsinclude comprehensive cellcharacterization, QA/QC, discoveryresearch and process development.www.biolog.com

Biosafe, present in 40 countries, isworld leader in automated adult stem cell processing for stem cellbanking and regenerative medicineapplications.

Sepax, Biosafe’s versatile lead technology, is a proprietary separation system that allows processing of various cellular products(cord & peripheral blood, bone marrow, etc.) from 35ml to 880ml.www.biosafe.ch

BioSpherix, Ltd. – Exhibit Booth No.38 - Exhibiting enabling technology for development and commercializa-tion of tissue engineered and othercell therapies. Unique PAT intensiveaseptic cell processing and incubationsystems close any process inside optimized production tunnel, providingsuperior process control unattainablein cleanroom processing. Economicalpractical alternative to “bricks-and-mortar” cleanrooms for cGMP cell production. www.biospherix.com

Covidien is a leading global healthcare products company thatcreates innovative medical solutionsfor better patient outcomes. Covidien manufactures, distributesand services a diverse range of product lines in four segments:Medical Devices, Imaging Solutions,Pharmaceutical Products andMedical Supplies. Covidien’s products are sold in over 130 countries. Please visit www.covidien.com.

DaVINCI Biomedical Researchis an AAALAC accredited contract lab performing GLP & Non-GLPstudies. We have extensive experience in RegenerativeMedicine, Cardiovascular andMedical Device applications; (wound, tissue, scaffold, Native &PTFE grafts, stents, angiogenesis,anastomosis, thrombosis, andmore). With our in-house surgicalskill, and vast knowledge of animalmodels from small to large animalmodels (mice to non-human primates), we offer you the highestlevel of preclinical animal testing.Check us out at www.davincibiomed.comor Contact Tony Nazal 919-661-8443 / / [email protected]

Bose Corporation’s ElectroForceSystems Group manufacturesElectroForce® test instruments usingproprietary linear motor technology.Bose offers instruments for the characterization of soft tissues, bones, biomaterials, and a variety of medical devices. The ElectroForceBioDynamic® test instrument providescharacterization and stimulation of tissue constructs in a biologicalenvironment. www.bose-electroforce.com

Clinical Translation Unit - The CTU is a joint project betweenResearch-and-Development-RA-SAand Hospital Universitario Austral in Argentina, in partnership withMcGowan Institute for RegenerativeMedicine. The main concept of theunit lies on having a state-of-the-artcell culture facility inside the OR, to facilitate the translation of benchtoptechnologies to the bedside. www.clinicaltranslation.com

Concordia Medical is an innovator in fiber and fabric based medicalimplants and scaffolds for regen-erative medicine. Concordia’sBIOFELT™ is a porous bioresorbablenon-woven scaffold, which facilitatesthe growth of cells and regeneration of continuous tissue structures andorgans. Concordia is ISO13485 certified and operates ISO7/ISO8medical clean rooms. www.concordiamedical.com

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EXHIBITORS

AABB, comprised of individuals and institutions, is an international,not-for-profit association dedicated tothe advancement of science and thepractice of transfusion medicine andrelated biological therapies. AABB is committed to improving health bydeveloping and delivering standards,accreditation and educational programs and services to optimizepatient and donor care and safety.www.aabb.org

Bacterin International is an innovative company focused on interventional therapies for improvingpatient outcomes. Our tissue engineering scaffold, OsteoSponge, is used with the patient’s own bonemarrow aspirate to provide anosteoinductive, osteoconductive, and osteogenic scaffold that supportsbone regeneration. OsteoSponge is indicated for any use as a bonevoid filler including subchondral bonevoid filler and craniotomies. www.bacterin.com

BioForce Nanosciences, Inc. creates products and solutions for the life sciences. BioForce’s flagshipproduct, the Nano eNabler™ molecular printer, gives its customersa platform for development and discovery by printing tiny domains of biological materials on surfaceswith nanometer spatial precision. www.bioforcenano.com

AABB: Booth No. 27

Bacterin: Booth No. 24

BioForce: Booth No. 48

Biolog: Booth No. 36

Biosafe: Booth No. 37

BioSpherix: Booth No. 38

Bose: Booth No. 41

Clinical Translation Unit:

Booth No. 44

Concordia: Booth No. 35

Covidien: Booth No. 39

DaVinci: Booth No. 42

FREDA: Booth No. 26

GTEC: Booth No. 32

EXHIBITORS

Cell Therapy News: Table Top Display No. 52

TERMIS: Table Top Disply No. 53

Mimesis, Inc. produces tissue specific, extra cellular matrices, derivedfrom decellularized tissues, for culturingstem and progenitor cells. Both twodimensional coatings and three dimen-sional scaffolds provide in vivo environ-ments for in vitro experiments in life science research activities. Retentionof matrix proteins, specific to tissues inquestion, provide an improved microen-vironment to encourage cell adhesion and migration, proliferation and survival, terminal tissue differentiation,and prolonged cell function.

The National Center for RegenerativeMedicine leverages the capabilities ofits partner institutions — Case WesternReserve University, Cleveland Clinic,and University Hospitals Case MedicalCenter — to provide a comprehensiveapproach, from basic through clinicalresearch, in developing innovative adult stem cell and tissue engineering therapies for patients suffering fromchronic and debilitating diseases.www.ncrm.us

StemSoft Software Inc. - StemLab™is the only complete laboratory manu-facturing software solution for cellulartherapy. Designed by StemSoftSoftware Inc, StemLab™ is built toensure quality and regulatory compli-ance standards are met by establishingprocedural protocols, monitoring manu-facturing processes, providing ISBT128 identifiers, and documenting lot-to-lot traceability. For further informationon StemLab visit www.stemsoft.comor contact us at 1-800-671-3234 [email protected]

FREDA BioChem - With over 20years of experience in R&D and thelarge scale production of hyaluronicacid, Freda Biochem is one of theworlds’ leading manufacturers of pharmaceutical grade HA. Our high quality GMP grade products are used widely in the ophthalmic, medical device, tissue engineering,and regenerative medicine fields.

The Georgia Tech/Emory Center(GTEC) for the Engineering of Living Tissues is a leader in thedevelopment of critical core technologies that are advancing the fields of tissue engineering andregenerative medicine. Our researchthrusts areas include: cardiovascular substitutes, neural tissue engineer-ing, metabolic/secretory organs, orthopedic tissue engineering and enabling biomaterial and stem cell technologies. www.gtec.gatech.edu

Glycosan BioSystems - GlycosanBioSystems HyStem line of hydrogelsprovides the bridge between cell culture and cell therapy. Our hydrogels are made from naturallyoccurring hyaluronan, can be easilymodified in terms of stiffness andcomposition, and have been usedsuccessfully to deliver bioactive molecules and cells for cartilage and bone repair.www.glycosan.com

IOP Publishing is an international,not-for-profit, learned society publisher. We are a world leader inscientific publishing and the electronicdissemination of peer-reviewedresearch. Visit us at booth #45 to learn more about our renownedpublication, Biomedical Materials, and sign up for a free subscription to our new journal, Biofabrication. IOP Publishing: The Public Ledger Building 150 S.Independence Mall W. Philadelphia,PA 19106; Phone: 215-627-0880;Fax: 215-627-0879www.iop.org/EJ/journal/BMM

Lifecore Biomedical – Hyaluronan is a component in commercial ophthalmic, orthopedic, aesthetic and veterinary medical products, as well as used in academic and corporate research. Lifecore supplies customers with a broadmolecular weight range of fermentedand purified hyaluronan in raw material or finished product configurations. Lifecore’s FDAregistered manufacturing facility is ISO 13485:2003 certified and compliant and staffed with qualifiedmedical professionals.www.lifecore.com

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Healionics Corporation provides biomaterial scaffold solutions to medical device manufacturers seek-ing to enhance the bio-integration of long-term implants. Their flagshipSTAR® biomaterial scaffolds improvehealing by reducing the foreign bodycapsule and increasing vascularizedtissue in-growth. STAR is available in various shapes and sizes and made from established, medicalgrade, synthetic substrates rangingfrom non-degradable (e.g. siliconerubber) to bioresorbable (e.g. hyaluronic acid). www.healionics.com

Histogen, Inc. is a regenerative medicine company developing solu-tions based on the products of new-born fibroblasts. The Company’s coretechnology simulates the embryonicenvironment, creating products thatare embryonic-like in nature withapplications ranging from biologics to research tools, including our recently released all-human stem cell culturing kit, BioNuesisTM.For more information, visit www.histogeninc.com.

Lonza - With more than 40 yearsexperience with normal human cells(Clonetics® and Poietics®), LonzaCell Therapy helps clients in all phases of cell therapy commercial-ization maximize the return on theirresearch investments. From tissueacquisition support and process development to full-scale cGMPcommercial manufacturing, our staffcan design, develop, and implement a manufacturing process that meetsyour needs for autologous or allo-geneic cell therapy. Our experienceincludes manufacture and testing of master and working cell banks,manufacturing from small to very large scale, regulatory support, media optimization, along with a host of other services. For more information, contact us at [email protected], or 800-654-4452 (301-898-7025 outside the US). www.lonza.com

The McGowan Institute forRegenerative Medicine is a partnership between the University of Pittsburgh and the University of Pittsburgh Medical Center andserves as a single base of operations for the 235 scientific and clinical faculty working to develop and translate tissueengineering, cellular therapy, and artificial & biohybrid organ technologies. www.mirm.pitt.edu

EXHIBITORS EXHIBITORS

TissueGnostics provides microscope-based cell analysis systems allowingthe user to automatically acquire andanalyze images of tissues, cultures,and smears. It enables the user toquantitatively analyze any substancewhich can be marked with immunoflu-orescent or immunohistochemicalmarkers. TissueGnostics offersTissueFAXS (microscope control),TissueQuest (immunofluorescenceanalysis) and HistoQuest (immuno-histochemistry analysis). www.tissuegnostics.com

Tissue Growth Technologies, a leading supplier of bioreactors formechanically-stimulated 3D tissuegrowth, offers products ranging frommodular components and accessoriesto fully integrated systems. Eachchamber imparts computer controlledmechanical forces to developing tissues in a real-time monitored, incubator friendly, sterile environment.TGT products allow researchers todesign experiments, not instruments.www.tissuegrowth.com

The Wake Forest Institute forRegenerative Medicine is an interna-tional leader in translating scientific discovery into clinical therapies. Itsphysicians and scientists were the firstin the world to engineer laboratory-grown organs that were implantedinto humans. Today, the institute is thelargest freestanding facility in the worlddevoted to regenerative medicine.www.wfirm.org

Tengion, a clinical stage biotech-nology company, focuses on develop-ing, manufacturing and commercializ-ing human neo-organs and neo-tissues using the AutologousOrgan Regeneration Platform™.Tengion uses biocompatible materialsand a patient’s own (autologous) cellsto create a functional neo-organ orneo-tissue that is designed to catalyze the body’s innate ability to regenerate. The Company’s lead product, the Neo-BladderAugment™, is currently in Phase 2clinical trials in the United States for pediatric patients with neurogenicbladder due to spina bifida and foradult patients with spinal cord injury.www.tengion.com

The Wake Forest Institute forRegenerative Medicine is an international leader in translating scientific discovery into clinical therapies. Its physicians and scientists were the first in the world to engineer laboratory-grown organsthat were implanted into humans.Today, the institute is the largest freestanding facility in the worlddevoted to regenerative medicine.www.wfirm.org

autologous or allogeneic cell therapy.Our experience includes manufactureand testing of master and working cell banks, manufacturing from small to very large scale, regulatorysupport, media optimization, alongwith a host of other services.For more information, contact us [email protected], or 800-654-4452 (301-898-7025 outside the US). www.lonza.com

Ratner BioMedical Inc., a regenera-tive medicine company, is focused on innovations in biomaterials, nanotechnology and the use of neu-rotrophic factors to advance a neuralregeneration platform. Technologiesfrom labs at Johns Hopkins and theUniversity of Washington promise ashift in the neurosurgical treatment of PNS trauma; even supplanting thecommon sural nerve graft solution to brachial plexus and other nervedamage.www.ratnerbiomedical.com

Synthasome, Inc. is an emergingbiotechnology company developingproducts for regenerative medicine,using tissue engineering technologies.The products will enhance repair ofdamaged or diseased tissues, with a primary focus on applications inorthopaedic and craniofacial surgery,targeting tendons and ligaments, and articular cartilage. Our first product is anticipated to be availablein the US in 2009. www.synthasome.com

AABB, comprised of individuals and institutions, is an international,not-for-profit association dedicated tothe advancement of science and thepractice of transfusion medicine andrelated biological therapies. AABB is committed to improving health bydeveloping and delivering standards,accreditation and educational programs and services to optimizepatient and donor care and safety.www.aabb.org

Bacterin International is an inno-vative company focused on interven-tional therapies for improving patientoutcomes. Our tissue engineeringscaffold, OsteoSponge, is used withthe patient’s own bone marrow aspi-rate to provide an osteoinductive,osteoconductive, and osteogenicscaffold that supports bone regenera-tion. OsteoSponge is indicated forany use as a bone void filler includingsubchondral bone void filler and cran-iotomies. www.bacterin.com

Baxter

Biosafe, present in 40 countries, is world leader in automated adultstem cell processing for stem cellbanking and regenerative medicineapplications. Sepax, Biosafe’s versa-tile lead technology, is a proprietaryseparation system that allows pro-cessing of various cellular products(cord & peripheral blood, bone marrow, etc.) from 35ml to 880ml.www.biosafe.ch

ORGANIZER:

The Tissue Engineering & RegenerativeMedicine International Society (TERMIS) brings together the international community of personsengaged or interested in the field of tissue engineering and regenerativemedicine and promotes education and research within the field of tissueengineering and regenerative medicinethrough regular meetings, publications

and other forms of communication. The Society also serves as an internationalforum to promote the informed discussion of challenges and therapeutic benefitsof the application of tissue engineering and regenerative medicine technologies.Most importantly, the Society is committed to bringing you closer to key professionals to support your mutual understanding of the field, accelerate your research in the field and to enable you to contribute to the ultimate care of patients in this very important way. To affect this interchange of information,the Society has endorsed the journal, Tissue Engineering, as its official publication and has negotiated a reduced subscription rate for members.www.termis.org

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CONFERENCE SPONSORS CONFERENCE SPONSORS

Covidien is a leading global health-care products company that createsinnovative medical solutions for better patient outcomes. Covidienmanufactures, distributes and services a diverse range of productlines in four segments: MedicalDevices, Imaging Solutions, Pharmaceutical Products and MedicalSupplies. Covidien’s products are sold in over 130 countries. Please visitwww.covidien.com.

Lifecore Biomedical – Hyaluronan is a component in commercial ophthalmic, orthopedic, aesthetic and veterinary medical products, as wellas used in academic and corporateresearch. Lifecore supplies cus-tomers with a broad molecular weightrange of fermented and purifiedhyaluronan in raw material or finishedproduct configurations. Lifecore’s FDA registered manufacturing facilityis ISO 13485:2003 certified and compliant and staffed with qualifiedmedical professionals.www.lifecore.com

Lonza - With more than 40 yearsexperience with normal human cells(Clonetics® and Poietics®), Lonza Cell Therapy helps clients in all phas-es of cell therapy commercializationmaximize the return on their researchinvestments. From tissue acquisitionsupport and process development tofull-scale cGMP commercial manufac-turing, our staff can design, develop,and implement a manufacturingprocess that meets your needs for

Karger is a leading international medical and scientific publisher.Our publications in the field like our journal CELLS TISSUES ORGANS(www.karger.com/cto) and especiallyour brand new book Meiosis, Vol. 5of the book series Genome Dynamics(www.karger.com/gendy), will certainly be of special interest to you.

Mary Ann Liebert, Inc., is a privatelyheld, fully integrated media companypublishing authoritative peer-reviewedjournals in new and promising areasof science and biomedical research,including Tissue Engineering - officialJournal of TERMIS—impact factor4.409. Visit www.liebertpub.comfor the complete list of over 60 publications.

Biomat.net is aimed at linking theBiomaterials and Tissue Engineeringcommunity worldwide. This site provides updated news, a monthlynewsletter, and also a collection ofselected internet links related toBiomaterials Science and TissueEngineering, as well as relevant linksto biomedical engineering, biology,medicine and health sciences in general. Facilities additionally includea glossary, a discussion forum and a job exchange section. www.biomat.net

Cell Therapy News - We know you’re busy. That’s why we compilethe latest cell therapy research, policyand business news, and deliver it toyour inbox in one weekly e-newsletter.Join more than 11,000 of your col-leagues - scientists and business professionals in the cell therapy industry – who receive Cell TherapyNews each week. Subscribe atwww.celltherapynews.com/subscribe.

Regenerationnet.com provides information on all fields of regenerative biology including tissueengineering, stem cell research, bio-materials, nutriceuticals and muchmore. The portal is available free of charge, providing concise profiles of companies and institutions, cutting-edge technologies, patentinformation, and news that are updated throughout the business day.www.regenerationnet.com

Integrated software Synchronized video analysis3mm–15mm specimen sizes

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MEDIA SPONSORS

2008 TERMIS NA Conference and Expo Planning Team

Bill Tawil, PhD, General Chair, Baxter

Anthony Ratcliff, Ph D, Co-Scientific Chair, Synthasome

Robert Sah, MD, ScD, Co-Scientific Chair, UCSD

Executive Production Provided by Forecast Technology Group, Inc.:

Anita CaufieldAndrea Lubienski, CMP

Gina Saxton

Administration and Registration Services Provided by PTEI

Autumn GindlespergerLaShon Jackson

Ruth Lee

Conference Liaison for TERMISSarah Wilburn

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Special thanks to

for their Sponsorship of this

Program Book

www.baxter.com

Scientific Advisory Committee

Kristi Anseth, PhDColorado University

Ravi Bellamkonda, PhDGeorgia Institute of Technology

Tim Bertram, PhDTengion, Inc., Winston-Salem

Yilin Cao, MD, PhDShanghai 9th People's Hospital, P.R. China

Gregory Evans, MDUniversity of California, Irvine

Larry Goldstein, PhDUniversity of California, San Diego

Nathalie Gosset, MS, MBAUniversity of Southern California

Timothy Hardingham, PhDThe University of Manchester, United Kingdom

Scott Hollister, PhDUniversity of Michigan

Ralf Huss, PhDRoche Diagnostics GmbH, Penzburg, Germany

Dietmar Hutmacher, PhDQueensland University of Technology, Australia

Jose Clemente Ibarra, MDNational Center for Rehabilitation, Mexico

Hai Bang Lee, PhDKorea Research Institute of Chemical Technology, South Korea

Ivan Martin, PhDUniversity Hospital Basel, Switzerland

Manuela Martins-Green, PhDUniversity of California, Riverside

Mark Mercola, PhDBurnham Institute for Medical Research

Shin-Yong Moon, PhDSeoul National University, South Korea

David J. Mooney, PhDHarvard University

Sanjay Nigam, MDUniversity of California, San Diego

Teruo Okano, PhDTokyo Women's Medical University, Japan

Jung Keug Park, PhDDongguk University, South Korea

Anthony Ratcliffe**, PhDSynthasome, Inc., San Diego

Buddy Ratner, PhDWashington University

A. Hari Reddi, PhDCenter for Tissue Regeneration and Repair

Robert Sah**, MD, ScDUniversity of California, San Diego

Michael Sefton, PhDUniversity of Toronto, Canada

Molly Shoichet, PhDUniversity of Toronto, Canada

Bill Tawil*, PhDBaxter BioScience, Westlake Village

Ben Wu, PhDUniversity of California, Los Angeles

James Yoo, MD, PhDWake Forest Institute for Regenerative Medicine

* Indicates Conference Chair** Indicates Scientific Committee Co-Chair

This year marks the culmination of seven exciting years of PTEI’s ownership and management of the annual tissue engineering meeting. Since 2001, PTEI has had the privilege to collaborate with the Tissue Engineering Society International, and morerecently the Tissue Engineering and Regenerative Medicine International Society (TERMIS) and their North American Council, in offering an outstanding industry-drivenprogram to the tissue engineering and regenerative medicine community.

On behalf of PTEI’s Board of Directors, I would like to thank the leadership,members and all those affiliated with TERMIS for their loyalty and support of PTEI in its endeavor to bridge geographic and scientific boundaries to link scientists and industry partners from around the world through the annual meeting.

In addition, I would like to recognize the efforts of the hundreds of people including scientific advisors, staff, committee members, volunteers, exhibitors, sponsorsand others who worked so diligently and contributed resources to the growth and development of the event over the years. Without them, this event would have notgrown from a regional-based meeting to a major international conference and exhibitionrepresenting the latest regenerative technology available in the industry.

And finally I would like to thank all those who attended the conference and have taken advantage of wonderful educational opportunities while attending cuttingedge tutorials, workshops, presentations, and posters and who have contributed theirthoughts, ideas and opinions to issues facing our profession which has influenced the evolution of the event.

Although PTEI will hand over the meeting to TERMIS in 2009, PTEI looks forward to continuing to support the annual meeting and TERMIS’s mission of bringingtogether the international community of persons engaged or interested in the field of tissue engineering and regenerative technologies and promoting education and research within the field through gatherings like the annual meeting.

Thank you again for all your support of this now independent meeting.

Sincerely,

Alan J. Russell, PhDDirector, PTEI

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DISCLAIMERThe material presented at the TERMIS NA 2008 Conference has been made available by the Tissue Engineer-ing and Regenerative Medicine International Society (TERMIS) for educational purposes only. The material isnot intended to represent the only, nor necessarily best, method or procedure appropriate for the medical situations discussed, but rather is intended to present an approach, view, statement or opinion of the facultywhich may be helpful to others who face similar situations. Tissue Engineering and Regenerative MedicineInternational Society (TERMIS) disclaims any and all liability for injury or other damages resulting to any individual attending the meeting and for all claims which may arise out of the use of the techniques demon-strated therein by such individuals, whether these claims shall be asserted by physician or any other person.

NOTICENo photography, video, audio recording or reproduction of any kind may be used during any portion of the TERMIS NA 2008 Conference. TERMIS NA reserves all of its rights to such materials, and commercial recording or reproduction is specifically prohibited. This includes, but is not limited to, digital and film photography, videography, cellular phones, and other image or audio recording devices.

Thank youto Forecast Technology

Group, Inc.for sponsoring

the pre-conference workshop

production.

www.conferencestrategists.com

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rats

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Documents

PROGRAM - TERMIS · • Jeff Lotz, PhD (University of California, San Francisco), Degeneration Models ... Speaker 2: Pierre Gianello, M.D. Ph.D. and Denis Dufrane, M.D. Ph.D. - University