Progesterone from the Milk of Pregnant Cows and Disease

8/9/2019 Progesterone from the Milk of Pregnant Cows and Disease

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Progesterone from the Milk of Pregnant Cows and Disease by Elisbeth Rieping 4

stimulated by progestins too Carnevale RP 2007.

In the moment it is tried to use uPA as marker for therapeutic decision making in breast cancer. Womenbearing breast cancer with low uPA unlikely to develop metastasis are encouraged to skip adjuvant

chemotherapy. More interesting might be to teach breast and other cancer patients to change their cancerphenotype to a favorable one by avoiding progesterone rich uPA inducing food.

Alkaline phosphatase

Alkaline phosphatase is mainly used as a tumormarker for prostate cancer. It can be tested to measure theeffect of progesterone on progesterone sensible cells Zava DT 1998. During pregnancy bone alkalinephosphatase of the mother goes up Hellmeyer L 2006. The same occurs in patients with rheumatic arthritis

Oelzner P 2007 and in cancer patients with bone metastases Lein M 2007.

TPS - tissue polypeptide-specific antigen

TPS also called cytokeratin-18 is a protein used as tumor marker is a protein found in maternal serum duringpregnancy Protonotaiou E 2006

HLA-G

Similar to the trophoblast protecting the embryo tumor-cells in vivo produce the progesterone inducibleleucocyte antigen HLA-G Urosevic 2008. This HLA-G is a progesterone inducible protein Yie SM 2006, notunlikely for a protein important during pregnancy. In tumor-cell-lines growing in vitro HLA-G cannot beobserved Polakova K 2000 as the culture medium will not contain progesterone.

The HLA-G gene has a unique progesterone responsive element PRE with homology to the RNA tumor virusPREs Yie SM 2006 some suspicious, some proven to induce human and animal tumors.

P-glycoprotein and breast cancer resistance protein

P-glcoprotein and breast cancer resistance protein protect cancer cells by making them resistant toexogenous poisons administered during chemotherapy for cancer treatment. During embryonic developmentthey perform this task in the placenta Mathias AA2005

Transforming growth factor-beta 1

Transforming growth factor-beta 1 (TGF-beta-1) is released progesterone dependent Kim MR 2005. Its


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production by tumor cells kills dendritic cells in sentinel lymph nodes draining breast cancers rendering thelymph nodes tolerant to invading tumor cells Ito M 2006.Elevated plasma TGF-beta1 levels correlate withdecreased survival of metastatic breast cancer patients Ivanovic V 2006.

Proteins repressed by progesterone which often do not work in tumor cells

p53

A very interesting protein in general not called tumor marker, as it is often absent or not working in tumorcells, is p53. It looks as if gets repressed in persons with high progesterone levels Lindstrom AK 2007.

Heat shock protein 70

It is not the only protein negatively controlled during pregnancy. Heat shock protein 70 is diminished inpregnant women Molvarec A 2007 In breast cancer patients it was shown to be most diminished in thosewomen who quickly succumb to their disease Torronteguy C 2006.

Consumption of milk proteins and Cancer

In April 2008 the Epic study on milk protein consumption development of prostate cancer was published Allen

NE 2008. It was done in many Europe countries. Data from 1142 520 men got analyzed. It could be shown thatprostate Cancer development increases 32% for every 35g of milk protein consumed.

Of cause, the researchers do not think that the protein itself is responsible for the cancer development. Inthe discussion they speculate about which hormone of the milk might be to blame. But IGF-1 a suspiciouscandidate increasing in blood after milk consumption will probably be destroyed in the stomach as proteins arein general. So the researchers cannot explain their results. Physicians and epidemiologists from profession theyare not familiar with modern milk production occurring during progesterone rich pregnancy of cows. But

progesterone does not get destroyed in the stomach. And it seems to induce igf-1 Queiroga FL 2008 being onemore progesterone induced protein.

What to do?

First to avoid milk products and to many progesterone rich eggs in the food and then of cause the future milkshould be produced outside of pregnancy of the animals. That should be possible quickly and willimprove the situation of seriously ill and still healthy persons who later might suffer under milk-born

progesterone contamination.


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Long studies are not necessary. A patient for example with breast cancer will see a rapid decline in tumormarkers like CA 15-3, a progesterone dependent protein which during pregnancy protects the embryo fromnatural killer cells. If all milk products are kept away from food, this diet, also known as Jane A. Plant Dietworks. Probably if there is no interference by cortisones which protect the tumor cells too Mattern J 2007. And

it does not work for breast cancer patients only. More quickly declines CA-125, the marker for cancer of theovary (own experience).

Discussion

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Progesterone from the Milk of Pregnant Cows and Disease