PROF. ALBERT HOFMAN Brookline, MA, USA Hardenberg, The ... · PROF. ALBERT HOFMAN. Indirizzo . Brookline, MA, USA. Telefono : Fax . E-mail . Nazionalità . Data di nascita Hardenberg,

Pagina 1 - Curriculum vitae di [ COGNOME, gnome ]

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INFORMAZIONI PERSONALI

Nome PROF. ALBERT HOFMAN Indirizzo Brookline, MA, USA Telefono

Fax E-mail

Nazionalità

Data di nascita Hardenberg, The Netherlands

ESPERIENZA LAVORATIVA

• Date (da – a) MD (University of Groningen, 1976), PhD (Erasmus University Rotterdam, 1983) • Nome e indirizzo del datore di lavoro Stephen B. Kay Family Professor of Public Health and Clinical Epidemiology, Harvard T.H. Chan School

of Public Health Chair, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA

• Tipo di azienda o settore

• Tipo di impiego • Principali mansioni e responsabilità

ISTRUZIONE E FORMAZIONE

• Date (da – a) 1968-1976 Medical school, University of Groningen, University of Leiden, The Netherlands. 1972-1975 Research fellow, department of Community Medicine, University of Groningen, The Netherlands. 1977-1979 Clinical residencies, departments of Internal Medicine, Academic Hospitals Groningen and Leiden, The Netherlands. 1980-1982 Research fellow with Prof. O.S. Miettinen, department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA (Prof. B. MacMahon

• Nome e tipo di istituto di istruzione o formazione

• Principali materie / abilità professionali oggetto dello studio

2016- Stephen B. Kay Family Professor of Public Health and Clinical Epidemiology, Harvard T.H. Chan School of Public Health. Chair, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2016(1)-2016(6) Visiting professor of clinical epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. 2 1998-2015 Professor of epidemiology (adjunct), Harvard University, Boston, Massachusetts, USA. 1992-2016 Science director Netherlands Institute for Health Sciences (Nihes), Rotterdam, The Netherlands. 1988- 2016 Professor of epidemiology; chairman Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. 1984-1988 Associate professor, Erasmus University Medical School, Rotterdam. 1981-1984 Assistant professor, Erasmus University Medical School, Rotterdam. 1977-1980 University instructor, Department of Epidemiology, Erasmus University Medical School, Rotterdam; residency in epidemiology with Prof. H.A. Valkenburg. Visiting appointments 2008(10)-2009(6) Visiting professor of epidemiology, London School of Hygiene and Tropical Medicine, London, UK. 1994, 1996 Visiting professor of clinical epidemiology, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass, USA. 1987(8)-1988(2) Visiting associate professor of epidemiology (Sergievsky Center), Columbia University, Faculty of Medicine, New York, NY, USA. Honors and distinctions 04-06-1983 Promotion, cum laude [with honors]. Dissertation: Blood pressure in childhood. Epidemiological probes into the aetiology of high blood pressure. Promotor: Prof. H.A. Valkenburg. 04-23-1992 Inaugural lecture at Erasmus University: On patients, populations and the Hippocratic epidemiology. 2002- Member Royal Netherlands Academy of Arts and Sciences. 11-08-2007 Honorary promotor Dr. Barry Bloom, Harvard University. 06-18-2012 Folksam Prize in Epidemiologic Research 2012, Karolinska Institutet, Stockholm, Sweden.

F O R M A T O E U R O P E O P E R I L C U R R I C U L U M

V I T A E



11-04-2013 Honorary doctorate, University of Belgrade, Belgrade, Serbia. Main academic achievements Number of publications: n=2,364, citations: n=132,136, h-index:169 (Web of Science, June 1, 2016) Selected publications (25 out of 2,364, for full publication list see appendix List of Publications) 1. Kavousi M, Leening MJ, Nanchen D, Greenland P, Graham IM, Steyerberg EW, Ikram MA, Stricker BH, Hofman A, Franco OH. Comparison of application of the ACC/AHA Guidelines, Adult Treatment Panel III Guidelines, and European Society of Cardiology Guidelines for cardiovascular disease prevention in a European cohort. JAMA. 2014;311(14):1416-23. 2. van Dijk FS, Zillikens MC, Micha D, Riessland M, Marcelis CL, de Die-Smulders CE, Milbradt J, Franken AA, Harsevoort AJ, Lichtenbelt KD, Pruijs HE, Rubio-Gozalbo ME, Zwertbroek R, Moutaouakil Y, Egthuijsen J, Hammerschmidt M, Bijman R, Semeins CM, Bakker AD, Everts V, Klein-Nulend J, Campos-Obando N, Hofman A, te Meerman GJ, Verkerk AJ, Uitterlinden AG, Maugeri A, Sistermans EA, Waisfisz Q, Meijers-Heijboer H, Wirth B, Simon ME, Pals G. PLS3 mutations in X-linked osteoporosis with fractures. N Engl J Med. 2013 Oct 17;369(16):1529-36. 3. Jonsson T, Stefansson H, Ph DS, Jonsdottir I, Jonsson PV, Snaedal J, Bjornsson S, Huttenlocher J, Levey AI, Lah JJ, Rujescu D, Hampel H, Giegling I, Andreassen OA, Engedal K, Ulstein I, Djurovic S, Ibrahim-Verbaas C, Hofman A, Ikram MA, van Duijn CM, Thorsteinsdottir U, Kong A, Stefansson K. Variant of TREM2 Associated with the Risk of Alzheimer's Disease. N Engl J Med. 2013;368:107-116. 4. Rietveld CA, Medland SE, Derringer J, Yang J, Esko T, Martin NW, Westra HJ, Shakhbazov K, Abdellaoui A, Agrawal A, Albrecht E, Alizadeh BZ, Amin N, Barnard J, Baumeister SE, Benke KS, Bielak LF, Boatman JA, Boyle PA, Davies G, de Leeuw C, Eklund N, Evans DS, Ferhmann R, Fischer K, Gieger C, Gjessing HK, Hägg S, Harris JR, Hayward C, Holzapfel C, Ibrahim-Verbaas CA, Ingelsson E, Jacobsson B, Joshi PK, Jugessur A, Kaakinen M, Kanoni S, Karjalainen J, Kolcic I, Kristiansson K, Kutalik Z, Lahti J, Lee SH, Lin P, Lind PA, Liu Y, Lohman K, Loitfelder M, McMahon G, Vidal PM, Meirelles O, Milani L, Myhre R, Nuotio ML, Oldmeadow CJ, Petrovic KE, Peyrot WJ, Polasek O, Quaye L, Reinmaa E, Rice JP, Rizzi TS, Schmidt H, Schmidt R, Smith AV, Smith JA, Tanaka T, Terracciano A, van der Loos MJ, Vitart V, Völzke H, Wellmann J, Yu L, Zhao W, Allik J, Attia JR, Bandinelli S, Bastardot F, Beauchamp J, Bennett DA, Berger K, Bierut LJ, Boomsma DI, Bültmann U, Campbell H, Chabris CF, Cherkas L, Chung MK, Cucca F, de Andrade M, De Jager PL, De Neve JE, Deary IJ, Dedoussis GV, Deloukas P, Dimitriou M, Eiríksdóttir G, Elderson MF, Eriksson JG, Evans DM, Faul JD, Ferrucci L, Garcia ME, Grönberg H, Guðnason V, Hall P, Harris JM, Harris TB, Hastie ND, Heath AC, Hernandez DG, Hoffmann W, Hofman A, Holle R, Holliday EG, Hottenga JJ, Iacono WG, Illig T, Järvelin MR, Kähönen M, Kaprio J, Kirkpatrick RM, Kowgier M, Latvala A, Launer LJ, Lawlor DA, Lehtimäki T, Li J, Lichtenstein P, Lichtner P, Liewald DC, Madden PA, Magnusson PK, Mäkinen TE, Masala M, McGue M, Metspalu A, Mielck A, Miller MB, Montgomery GW, Mukherjee S, Nyholt DR, Oostra BA, Palmer LJ, Palotie A, Penninx BW, Perola M, Peyser PA, Preisig M, Räikkönen K, Raitakari OT, Realo A, Ring SM, Ripatti S, Rivadeneira F, Rudan I, Rustichini A, Salomaa V, Sarin AP, Schlessinger D, Scott RJ, Snieder H, St Pourcain B, Starr JM, Sul JH, Surakka I, Svento R, Teumer A; LifeLines Cohort Study, Tiemeier H, van Rooij FJ, Van Wagoner DR, Vartiainen E, Viikari J, Vollenweider P, Vonk JM, Waeber G, Weir DR, Wichmann HE, Widen E, Willemsen G, Wilson JF, Wright AF, Conley D, Davey-Smith G, Franke L, Groenen PJ, Hofman A, Johannesson M, Kardia SL, Krueger RF, Laibson D, Martin NG, Meyer MN, Posthuma D, Thurik AR, Timpson NJ, Uitterlinden AG, van Duijn CM, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD. GWAS of 126,559 individuals identifies genetic variants associated with educational attainment. Science. 2013 Jun 21;340(6139):1467-71. 5. Emerging Risk Factors C, Kaptoge S, Di Angelantonio E, Pennells L, Wood AM, White IR, Gao Amouyel P, Assmann G, Bakker SJ, Barr EL, Barrett-Connor E, Benjamin EJ, Bjorkelund C, Brenner H, Brunner E, Clarke R, Cooper JA, Cremer P, Cushman M, Dagenais GR, D'Agostino RB, Sr., Dankner R, Davey-Smith G, Deeg D, Dekker JM, Engstrom G, Folsom AR, Fowkes FG, Gallacher J, Gaziano JM, Giampaoli S, Gillum RF, Hofman A, Howard BV, Ingelsson E, Iso H, Jorgensen T, Kiechl S, Kitamura A, Kiyohara Y, Koenig W, Kromhout D, Kuller LH, Lawlor DA, Meade TW, Nissinen A, Nordestgaard BG, Onat A, Panagiotakos DB, Psaty BM, Rodriguez B, Rosengren A, Salomaa V, Kauhanen J, Salonen JT, Shaffer JA, Shea S, Ford I, Stehouwer CD, Strandberg TE, Tipping RW, Tosetto A, Wassertheil-Smoller S, Wennberg P, Westendorp RG, Whincup PH, Wilhelmsen L, Woodward M, Lowe GD, Wareham NJ, Khaw KT, Sattar N, Packard CJ, Gudnason V, Ridker PM, Pepys MB, Thompson SG, Danesh J. C-reactive protein, fibrinogen, and cardiovascular disease prediction. N Engl J Med. 2012 Oct 4;367(14):1310-20. 6. Den Ruijter HM, Peters SA, Anderson TJ, Britton AR, Dekker JM, Eijkemans MJ, Engstrom G, Evans GW, de Graaf J, Grobbee DE, Hedblad B, Hofman A, Holewijn S, Ikeda A, Kavousi M, Kitagawa K, Kitamura A, Koffijberg H, Lonn EM, Lorenz MW, Mathiesen EB, Nijpels G, Okazaki S, O'Leary DH, Polak JF, Price JF, Robertson C, Rembold CM, Rosvall M, Rundek T, Salonen JT, Sitzer M, Stehouwer CD, Witteman JC, Moons KG, Bots ML. Common carotid intima- media thickness measurements in cardiovascular risk prediction: a meta-analysis. JAMA. 2012 Aug 22;308(8):796-803. 7. Hofman A, van Duijn CM, Franco OH, Ikram MA, Janssen HL, Klaver CC, Kuipers EJ, Nijsten TE, Stricker BH, Tiemeier H, Uitterlinden AG, Vernooij MW, Witteman JC. The Rotterdam Study: 2012 objectives and design update. Eur J Epidemiol. 2011; Aug;26(8):657-686. 8. Schrijvers EM, Koudstaal PJ, Hofman A, Breteler MM. Plasma clusterin and the risk of Alzheimer disease. JAMA. 2011 Apr 6;305(13):1322-6. 9. Solouki AM, Verhoeven VJ, van Duijn CM, Verkerk AJ, Ikram MK, Hysi PG, Despriet DD, van Koolwijk LM, Ho L, Ramdas WD, Czudowska M, Kuijpers RW, Amin N, Struchalin M, Aulchenko YS, van Rij G, Riemslag FC, Young TL, Mackey DA, Spector TD, Gorgels TG, Willemse-Assink JJ, Isaacs A, Kramer R, Swagemakers SM, Bergen AA, van Oosterhout AA, Oostra BA, Rivadeneira F, Uitterlinden AG, Hofman A, de Jong PT, Hammond CJ, Vingerling JR, Klaver CC. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet. 2010 Oct;42(10):897-901. 10. Lp PLASC, Thompson A, Gao P, Orfei L, Watson S, Di Angelantonio E, Kaptoge S, Ballantyne C, Cannon CP, Criqui M, Cushman M, Hofman A, Packard C, Thompson SG, Collins R, Danesh J. Lipoprotein-associated phospholipase A(2) and risk of coronary disease, stroke, and mortality: collaborative analysis of 32 prospective studies. Lancet. 2010 May 1;375(9725):1536-44. 5 11. Ikram MA, Seshadri S, Bis JC, Fornage M, DeStefano AL, Aulchenko YS, Debette S, Lumley T, Folsom AR, van den Herik EG, Bos MJ, Beiser A, Cushman M, Launer LJ, Shahar E, Struchalin M, Du Y, Glazer NL, Rosamond WD, Rivadeneira F, Kelly-Hayes M, Lopez OL, Coresh J, Hofman A, DeCarli C, Heckbert SR, Koudstaal PJ, Yang Q, Smith NL, Kase CS, Rice K,



Haritunians T, Roks G, de Kort PL, Taylor KD, de Lau LM, Oostra BA, Uitterlinden AG, Rotter JI, Boerwinkle E, Psaty BM, Mosley TH, van Duijn CM, Breteler MM, Longstreth WT Jr, Wolf PA. Genomewide association studies of stroke. N Engl J Med. 2009 Apr 23;360(17):1718-28. 12. Newton-Cheh C, Eijgelsheim M, Rice KM, de Bakker PI, Yin X, Estrada K, Bis JC, Marciante K, Rivadeneira F, Noseworthy PA, Sotoodehnia N, Smith NL, Rotter JI, Kors JA, Witteman JC, Hofman A, Heckbert SR, O'Donnell CJ, Uitterlinden AG, Psaty BM, Lumley T, Larson MG, Stricker BH. Common variants at ten loci influence QT interval duration in the QTGEN Study. Nat Genet. 2009 Apr;41(4):399-406. 13. Dehghan A, Köttgen A, Yang Q, Hwang SJ, Kao WL, Rivadeneira F, Boerwinkle E, Levy D, Hofman A, Astor BC, Benjamin EJ, van Duijn CM, Witteman JC, Coresh J, Fox CS. Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study. Lancet. 2008 Dec 6;372(9654):1953-61. 14. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJ, Hofman A, Krestin GP, Niessen WJ, Breteler MM, van der Lugt A. Incidental findings on brain MRI in the general population. N Engl J Med. 2007 Nov 1;357(18):1821-8. 15. Meurs JB van, Dhonukshe-Rutten RA, Pluijm SM, Klift M van der, Jonge R de, Lindemans J, Groot LC de, Hofman A, Witteman JC, Leeuwen JP van, Breteler MM, Lips P, Pols HA, Uitterlinden AG. Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 2004;350:2033-41. 16. Vermeer SE, Prins ND, den Heijer T, Hofman A, Koudstaal PJ, Breteler MMB. Silent brain infarcts and the risk of dementia and cognitive decline. N Engl J Med. 2003;348:1215-22. 17. Veld BA in ‘t, Ruitenberg A, Hofman A, Launer LJ, Duijn CM van, Stijnen T, Breteler MMB, Stricker BHC. Nonsteroidal antiinflammatory drugs and the risk of Alzheimer’s disease. N Engl J Med. 2001;345:1515-21. 18. Uitterlinden AG, Burger H, Huang Q, Yue F, McGuigan FEA, Grant SFA, Hofman A, Leeuwen JPTM van, Pols HAP, Ralston SH. Relation of alleles of the collagen type 11 gene to bone density and the risk of osteoporotic fractures in postmenopausal women. N Engl J Med. 1998;338:1016-21. 19. Hofman A, Ott A, Breteler MMB, Bots ML, Slooter AJC, Harskamp F van, Duijn CM van, Broeckhoven C van, Grobbee DE. Atherosclerosis, apolipoprotein and prevalence of dementia and Alzheimer’s disease. The Rotterdam Study. Lancet. 1997;349:151-4. 20. Will RG, Ironside JW, Zeidler M, Cousens SN, Estibeiro K, Alprovitch A, Poser S, Pocchari M, Hofman A, Smith PG. A new variant of Creutzfeldt-Jakob disease in the UK. Lancet. 1996;347:921-5. 6 21. Duijn CM van, Knijff P de, Cruts M, Wehnert A, Havekes LM, Hofman A, Broeckhoven C van. Apolipoprotein E4 allele in a population based study of early onset Alzheimer’s disease. Nat Genet. 1994;7:74-9. 22. Hendriks L, Duijn CM van, Cras P, Cruts M, Hul W van, Harskamp van F, Warren A, Innis Mc MG, Antonara SE, Martin JJ, Hofman A, Broeckhoven C van. Presenile-dementia and cerebralhemorrhage linked to a mutation at codon-692 of the beta-amyloid precursor protein gene. Nat Genet. 1992;1:218-21. 23. Hooft IMS van,Grobbee DE,Derkx FHM, Leeuw PW de,Schalekamp MADH,Hofman A. Renal hemodynamics and the renin-angiotensin-aldosterone system in the early phase of primary hypertension. N Engl J Med. 1991;324:1305-11. 24. Walter HJ, Hofman A, Vaughan RD, Wynder E. Modification of risk factors for coronary heart disease. Five-year results of a school-based intervention trial. N Engl J Med. 1988;318:1093-100. 25. Hofman A, Hazebroek A, Valkenburg HA. A randomized trial of sodium intake and blood pressure in newborn infants. JAMA. 1983;250:370-3. Grants 1988-2004 Various grants for the development and maintenance of the Rotterdam Study, obtained from the European Union, DG12 European Commission, European Science Foundation, Netherlands Organization for Scientific Research, Netherlands Medical Research Council, Netherlands Ministry of Education and Science, and Netherlands Ministry of Health. 2001-2004 Various grants for the development of the Generation R Study, obtained from the European Union, Wellcome Trust, Netherlands Medical Research Council, and Netherlands Ministry of Health. 2004-2008 Rotterdam Study infrastructure grant (continuation), Netherlands Medical Research Council (k€ 2,400), PI. 2004-2009 Generation R infrastructure grant (competitive renewal), Netherlands Ministry of Health (k€ 4,200), PI. 2008-2012 Genomic studies in the Rotterdam Study, genome-wide association studies, Netherlands Organization for Scientific Research (k€ 8,200), co-PI. 2008-2012 ENGAGE European Consortium for genomic studies in the Rotterdam Study (k€ 351), co-PI. 2008-2012 Research Institute for Diseases in the Elderly, Netherlands Consortium of Healthy Aging, Netherlands Genomic Initiative (k€ 6,200), PI. 2009-2013 ERACOL Erasmus Mundus Master and PhD exchange programme in the health sciences, European Commission (k€ 3,900), PI. 7 2009-2012 Collaborative GWAs of dementia, AD and related MRI and cognitive phenotypes, RO1 AG033193 (NIH, Boston University, Seshadri PI), (subcontract k$ 237), Rotterdam Study co-investigator. 2009-2014 Generation R Focus@8 infrastructure grant, Netherlands Ministry of Youth (k€4,400), co-PI. 2011-2013 Marginal structural models for analyses for time-dependent drug use in observational studies, Netherlands Medical Research Council (k€ 125), co-PI. 2011-2014 Clinical Epidemiology Graduate Programme, Netherlands Organization for Scientific Research (k€ 800), PI. 2011-2013 CHARGE Consortium: Gene discovery for CVD and aging phenotypes, IR01 HL105756 (NIH, University of Washington, Psaty PI, (subcontract k$ 81), coinvestigator. 2012-2015 ERAWEB, Erasmus Mundus Master and PhD Programme in clinical epidemiology, European Commission (k€ 4,400), PI. 2012-2014 The Atherosclerosis Risk in Communities - Neurocognitive Study (ARIC NCS), 5U01 HL096917 NIH, University of Mississippi, Mosley PI), (subcontract k$ 183), Rotterdam Study co-investigator. 2012-2016 Risk factors for ventricular arrhythmia and sudden cardiac death as an adverse reaction of commonly used drugs in the elderly, Netherlands Medical research Council (k€ 600), PI. 2013-2017 AD Gene Discovery: Exome chip, new endophenotypes and functional studies in CHARGE, 5RO1 AG033193-04 (NIH, Boston University, Seshadri PI), (subcontract k$ 269), Rotterdam Study co-investigator. 2014-2017 ERAWEB II, Erasmus Mundus Master and PhD Programme in clinical epidemiology, European Commission (k€ 4,900), PI. 2014-2018 An integrated genetic and epigenetic approach to cerebral small vessel disease, 1RO1 NS087541 (NIH, University of Texas, Houston, Fornage PI), (subcontract k$ 199), Rotterdam Study co-investigator. Major professional service * Principal Investigator Rotterdam Study (1987-). * Chairman section Health Sciences of the Netherlands Organization of Scientific Research (1988-1994). * Chairman section Medical Sciences of the Netherlands Organization for Scientific Research NWO (1995-1998). * Chairman European Medical Research Councils (EMRC), European Science Foundation (1998-1999). * Member Netherlands Health Council (Gezondheidsraad) (1991-2000 and 2012- 2015). 8 * Principal Investigator Generation R Study (2002-). * Chairman Standing Review Committee Danish Council for Independent Research | Medical Sciences (2010- ). * Chairman International Scientific Board, German National Cohort, Heidelberg, Germany (2007- ). * Member Senat Helmholtz Gemeinschaft, Berlin,



Germany (2011-2015). Major administrative responsibilities * Chairman Department of Epidemiology, Erasmus Medical Center (1988-2016 ). * Science director Netherlands Institute for Health Sciences (Nihes) (1992- 2016). Editorial Boards * Editor-in-chief European Journal of Epidemiology (2002- ). * Member editorial board European Journal of Clinical Investigation, European Journal of Public Health, Preventive Medicine, Age and Ageing, Revue d'Epidemiologie et de la Santé Publique. Major research interests * Epidemiology of neurologic diseases Studies on the incidence and risk factors of Alzheimer's disease, vascular dementia, Parkinson's disease and Creutzfeldt-Jakob disease. * Epidemiology of cardiovascular disease Studies of determinants of heart disease and stroke, and of the pathogenesis of atherosclerosis. * Clinical epidemiology Contributions to clinical trials of cardiovascular diseases (trombolysis, oral anticoagulation, cholesterol-lowering drugs). Teaching * Erasmus University Teaching of medical students in general epidemiology and methods of research in medicine and clinical epidemiology; contributions to postgraduate programmes and courses in internal medicine, neurology, pediatrics, cardiology and community medicine. * Harvard School of Public Health | Harvard Medical School Annual courses Epi 500, Epi 208 and Epi 210. 9 * Netherlands Institute for Health Sciences Teaching of graduate students in epidemiologic research methods and clinical research methods in MSc, DSc and PhD programs. * International teaching * Programme director and faculty member of the annual Erasmus Summer Programme in Quantitative Medical Research Methods, Rotterdam, The Netherlands. * Winter School in Clinical Epidemiology, Hall, Austria, annual course on Clinical Epidemiology. * Karolinska Institutet, Stockholm, annual course on Clinical Epidemiology. * Ludwig-Maximillians Universität, Munich, Germany; annual course on Clinical Epidemiology. Promovendi [PhD dissertations] * D.E. Grobbee Electrolytes in early primary hypertension. An epidemiological approach. Erasmus University Rotterdam, June 18, 1986. * W.A.H.J. van Stiphout Serum lipids in the young. An epidemiological view of early atherogenesis. Erasmus University Rotterdam, November 19, 1986. * A.A.A. Bak Coffee and cardiovascular risk; an epidemiological study. Erasmus University Rotterdam, September 5, 1990. * S.A. de Man Physical fitness and cardiovascular risk factors in children. An epidemiological perspective. Erasmus University Rotterdam, May 29, 1991. * J.W.W. Coebergh Incidence and prognosis of cancer in The Netherlands: studies based on cancer registries. Erasmus University Rotterdam, June 5, 1991. * J.C.M. Witteman Cardiovascular disease in women. An epidemiological study of atherogenic factors. Erasmus University Rotterdam, November 27, 1991. * C.M. van Duijn Risk factors for Alzheimer's disease: a genetic-epidemiologic study. Erasmus University Rotterdam, January 29, 1992. * A.W. Hoes Diuretics and sudden cardiac death in hypertensive patients. A pharmacoepidemiologic study. Erasmus University Rotterdam, December 16, 1992. * J.J. Claus Alzheimers disease: studies in diagnosis and therapy. Erasmus University Rotterdam, March 10, 1993. 10 * M.M.B. Breteler Cognitive decline in the elderly. Epidemiologic studies on cognitive function and dementia. Erasmus University Rotterdam, June 18, 1993. * A.A.J.M. Hazebroek-Kampschreur Trunk abnormalities in adolescence. A school health care based epidemiological cohort study. Erasmus University Rotterdam, September 22, 1993. * M.L. Bots Wall thickness of the carotid artery as an indicator of generalized atherosclerosis. Erasmus University Rotterdam, September 29, 1993. E. Odding Locomotor disability in the elderly. Erasmus University Rotterdam, October 19, 1994. * I.S.M. van Hooft The Dutch hypertension and offspring study; an epidemiological approach to the early pathogenesis of primary hypertension. Erasmus University Rotterdam, November 16, 1994. * P.F.M.M. van Bergen Long-term oral anticoagulant treatment after myocardial infarction. Erasmus University Rotterdam, November 23, 1994. * H.W. Nab Trends in the incidence and prognosis in female breast cancer since 1995. Registry-based studies in south-east Netherlands. Erasmus University Rotterdam, March 15, 1995. * I. Dielemans Prevalence and determinants of glaucoma. An epidemiologic approach. The Rotterdam Study. Erasmus University Rotterdam, April 19, 1995. * J.R. Vingerling Epidemiology of age-related maculopathy. Erasmus University Rotterdam, May 24, 1995. * C.S.P.M. Uiterwaal Lipids and atherosclerosis in families. Erasmus University Rotterdam, June 7, 1995. * H. Burger Epidemiologic studies on bone mineral density and fractures. Erasmus University Rotterdam, December 6, 1995. * P.L.A. van Daele Prediction of osteoporotic fractures. The Rotterdam Study. Erasmus University Rotterdam, April 24, 1996. * D.P.W.M. Wientjens Epidemiology of Creutzfeldt-Jacob disease. Incidence, risk factors and survival in European studies. 11 Erasmus University Rotterdam, May 7, 1997. * M.C. de Rijk Epidemiology of Parkinson’s disease. The Rotterdam Study. Erasmus University Rotterdam, September 10, 1997. * A. Ott Risk of Dementia. The Rotterdam Study. Erasmus University Rotterdam, September 17, 1997. * S. Kalmijn Risk factors for cognitive decline. Erasmus University Rotterdam, November 26, 1997. * E.B. Samrén Maternal epilepsy and pregnancy outcome. A population-based study. Erasmus University Rotterdam, April 15, 1998. * A.J.C. Slooter The role of apolipoprotein E in atherosclerosis and dementia. An epidemiological approach to genetic susceptibility. Erasmus University Rotterdam, September 9, 1998. * M.L.G. Janssen-Heijnen Trends in lung cancer incidence and survival. Studies based on cancer registries. Erasmus University Rotterdam, September 30, 1998. * C. Bijkerk Genetic epidemiology of osteoarthritis. Studies of familial aggregation and candidate genes. Erasmus University Rotterdam, March 3, 1999. * H.F. de Leeuw Determinants of cerebral white matter lesions. A longitudinal population based MRI- study. Erasmus University Rotterdam, March 10, 1999. * C.E.D.H. de Laet Osteoporosis and fracture prevention: costs and effects modeled on the Rotterdam Study. Erasmus University Rotterdam, March 17, 1999. * J.C. de Groot Consequences of cerebral white matter lesions. A longitudinal population-based MRI-study. Erasmus University Rotterdam, March 24, 1999. * P.N. Post Incidence and survival of prostate cancer since 1970. Erasmus University Rotterdam, March 31, 1999. * K. Klipstein-Grobusch Pro- and antioxidants and risk of atherosclerosis and coronary heart disease in the elderly. Erasmus University Rotterdam, May 19, 1999. * R.C.W. Wolfs Changing views on open-angle glaucoma. The Rotterdam study. Erasmus University Rotterdam, June 9, 1999.

A. Molarius Determinants of relative weight and body fat distribution in an international perspective. Erasmus University Rotterdam, November 24, 1999. * I.C.D. Westendorp Estrogen, atherosclerosis and cardiovascular disease in women. Epidemiological studies on menopause and hormone replacement therapy. Erasmus University Rotterdam, December 1, 1999. * C.C.W. Klaver Genetic epidemiologic studies on age-related maculopathy. A population-based



approach. Erasmus University Rotterdam, January 5, 2000. * J.J.M. Assink Age-related maculopathy: a genetic and epidemiological approach. Erasmus University Rotterdam, March 29, 2000. * B.S. Harhangi Genetic susceptibility to Parkinson’s Disease. Erasmus University Rotterdam, April 12, 2000. * Z. Vokó Etiology and prevention of stroke. The Rotterdam Study. Erasmus University Rotterdam, June 21, 2000. * N.M. van Popele Causes and consequences of arterial stiffness. an epidemiological approach. Erasmus University Rotterdam, September 6, 2000. * A. Ruitenberg Vascular factors in dementia. Observations in the Rotterdam Study. Erasmus University Rotterdam, December 13, 2000. * B.A. in ‘t Veld Pharmacological prevention of dementia. A pharmacoepidemiological approach in the Rotterdam Study. Erasmus University Rotterdam, October 4, 2000. * M.M. van Riemsdijk Neuropsychiatric effects of antimalarial drugs. Erasmus University Rotterdam, January 31, 2001. * S.L.M. Bakker Cerebral hemodynamic indices measured by means of transcranial Doppler. Erasmus University Rotterdam, April 4, 2001. * S. Houterman Public health aspects of serum cholesterol. Erasmus University Rotterdam, May 23, 2001. * A.E.A.M. Weel Skeletal and genetic determinants of osteoporosis. Erasmus University Rotterdam, May 30, 2001.

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ALTRE LINGUA

[ Indicare la lingua ] • Capacità di lettura [ Indicare il livello: eccellente, buono, elementare. ]

• Capacità di scrittura [ Indicare il livello: eccellente, buono, elementare. ] • Capacità di espressione orale [ Indicare il livello: eccellente, buono, elementare. ]


RELAZIONALI Vivere e lavorare con altre persone, in

ambiente multiculturale, occupando posti in cui la comunicazione è importante e in situazioni in cui è essenziale lavorare in

squadra (ad es. cultura e sport), ecc.

[ Descrivere tali competenze e indicare dove sono state acquisite. ]


ORGANIZZATIVE Ad es. coordinamento e amministrazione di persone, progetti, bilanci; sul posto di lavoro, in attività di volontariato (ad es.

cultura e sport), a casa, ecc.



TECNICHE Con computer, attrezzature specifiche,

macchinari, ecc.



ARTISTICHE Musica, scrittura, disegno ecc.


ALTRE CAPACITÀ E COMPETENZE

Competenze non precedentemente indicate.


PATENTE O PATENTI

ULTERIORI INFORMAZIONI [ Inserire qui ogni altra informazione pertinente, ad esempio persone di riferimento, referenze

ecc. ]

ALLEGATI [ Se del caso, enumerare gli allegati al CV. ]

Documents

PROF. ALBERT HOFMAN Brookline, MA, USA Hardenberg, The ... · PROF. ALBERT HOFMAN. Indirizzo . Brookline, MA, USA. Telefono : Fax . E-mail . Nazionalità . Data di nascita Hardenberg,