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Electrophysiology Electrochemistry

HEKA provides the finest instruments today to achieve the needed progress of tomorrow…

Product Overview Version 1/2010

If you believe your job is tomake new discoveries...

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About us

Further Reading

HEKA is a distributor of

For over forty years HEKA has designed and manufactured sophisticated instrumentation and software for biomedical and Industrial research applications. Through the years HEKA has achieved an unparalleled reputation for precision and quality. Most medical, pharmaceutical and industrial research facilities world-wide rely on HEKA ingenuity for their discoveries.Throughout these forty years there have been so many changes in research, instrumentation and soft-ware. The one constant that has remained the same is our commitment, to bring innovative technology to our most important business partner, our customer. HEKA is a select group of electrical engineers, biomedical researchers, and computer scientists who pride themselves on the quality of HEKA products and customer support. HEKA is big enough to offer complete pre- and post-sales technical support, while still small enough to give exclusive attention to each customer. HEKA designs, fabricates, tests, perfects, sells and services systems. In every way, HEKA provides solutions.If any questions arise while previewing our web site please do not hesitate to contact us!

Additional information such as manuals, technical specifications and PDF brochures for most HEKA products listed in this catalog can be downloaded directly from our web site at www.heka.com.

Ionovation GmbH - www.ionovation.com HEKA is the exclusive sales partner for the Ionovation product range covering bilayer applications. The product range covers Ionovation Compact (complete automated bilayer setup), Ionovation Bilayer Explorer (electro-optical setup with inverted microscopes). Please contact HEKA directly for quotations.

SUTTER INSTRUMENT COMPANY - www.sutter.comHEKA is sales partner of Sutter in Germany, Austria, USA, Canada and Latin America. The product range covers Pipette Pullers, Micromanipulators, Microscope Translation Systems, Light Sources, Wavelength Switcher, Filter Wheels, Shutters and instrumentation for Microinjection. Please contact HEKA directly for quotations.

ALA SCIENTIFIC INSTRUMENTS INC. - www.alascience.comHEKA is an official reseller for products manufactured by ALA Scientific. The product range covers Bath and Local Perfusion Systems, Perfusion Outlet Manifolds, Coater/Polisher Microforge, Whole Cell Perfu-sion system, Fluid Level Controller etc. Please contact HEKA directly for quotations.

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Product OverviewContents

Patch Clamp Amplifiers • Computer Controlled Amplifiers ________ 4 • Manually Controlled Amplifiers _________ 5 • Accessories _________________________ 6

Oocyte Clamp Amplifiers ________________ 7

Potentiostats / Galvanostats • Computer Controlled Potentiostats / Galvanostats ___________ 8 • Manually Controlled Potentiostats / Galvanostats ___________ 9 • Accessories ________________________ 10

Microelectrode Amplifiers ______________ 11

Acquisition Hardware • AcquisitionInterface _________________ 12 • HostInterfaceBoards ________________ 12

Software • Acquisition&Analysis _______________ 13 • GLPSoftware _______________________ 15 • AdditionalSoftware __________________ 16

Pipette and Electrode Manufacturing • PipettePuller _______________________ 18 • Holders ____________________________ 18 • Electrodes __________________________ 19

Electrochemical Cells • ElectrochemicalCells ________________ 20 • Electrodes __________________________ 20

Electric Shielding ______________________ 21

Complete Systems

Electrochemical Probe Scanner (SECM)____ 22

Bilayer _________________________________ 23

Light Pattern Generator __________________ 24

Patch Clamp ___________________________ 24

Further Products_______________________ 25

Terms and Conditions __________________ 26

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Computer Controlled Amplifiers

The EPC 10 USB Family - ThefullycomputercontrolledPatchClampAmplifiersoftheEPC10USBfamilyarenowintegratedwiththeLIH8+8A/DD/Adataacquisitioninterfaceandconnectedtothecom-puterviaaUSB2.0hostinterface.

EPC 10 USB Patch Clamp AmplifierOne Patch Clamp Amplifier and Data Acquisition, USB version with LIH 8+8 interface in one housing.

EPC 10 USB Double Patch Clamp AmplifierTwo Patch Clamp Amplifiers and Data Acquisition, USB version with LIH 8+8 interface in one housing.

EPC 10 USB Triple Patch Clamp AmplifierThree Patch Clamp Amplifiers and Data Acquisition, USB ver-sion with LIH 8+8 interface in one housing.

EPC 10 USB Quadro Patch Clamp AmplifierFour Patch Clamp Amplifiers and Data Acquisition, USB version with LIH 8+8 interface in one housing.

Patch Clamp Amplifiers

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Manually Controlled Amplifiers

Stand-alone Patch Clamp Amplifiers for manual operation.

EPC 10 PLUS(USBorPCIversion) - ThefullycomputercontrolledPatchClampAmplifieroftheEPC10PLUSfamilyintegratestheITC-18A/DD/AdataacquisitioninterfacethatcanbeconnectedwiththecomputereitherwithaPCI-18hostcardorUSB-18hostinterface.

EPC 10 USB Options

EPC 800 Patch Clamp AmplifierWith manual control and comput-er control via USB 2.0 interface.

EPC 8 Patch Clamp AmplifierWith selectable Remote or Local operation modes in conjunc-tion with HEKA data acquisition interface and software.

EPC 10 PLUS Patch Clamp AmplifierOne Patch Clamp Amplifier and Data Acquisition Interface in one housing.

EPC 10 PLUS Double Patch Clamp AmplifierTwo Patch Clamp Amplifiers and Data Acquisition Interface in one housing.

Extended Patch Clamp Amplifier SystemsParallel Extension:Two EPC 10 USB or one EPC 10 USB and one data acquisition interface (e.g. LIH 8+8) can be connected to extend the number of recording channels. Any combination of EPC 10 USB amplifiers is possible. Here are three examples:EPC 10 USB Quadro + EPC 10 USB QuadroEPC 10 USB Double + EPC 10 USB SingleEPC 10 USB Triple + LIH 8+8 interface

SerialExtension:Alternatively, the EPC 10 USB amplifier can be extended with an EPS 16 Probe Selector turning a single EPC 10 patch clamp amplifier into a serial patch clamp device with up to 16 channels.

Patch Clamp Amplifiers

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Accessories Patch Amperometry HeadstageHeadstage for EPC 10 patch clamp amplifier with ground routing switchable between GND plug and BNC shield. Compatible with typi-cal patch-amperometry electrode holders. Can be used in combination with an EPC USB Double patch clamp amplifier for combined patch amperometry and On-Cell capacitance measurements.Available with a new EPC 10 USB or as additional headstage to up-grade your EPC 10.

3-Electrode Mode HeadstageSupports a third potential measuring electrode. The potential between reference and ground electrode is measured and automatically added to the potential between working and ground electrode. Typical applications:• accountforchangingliquidjunctionpotentials,• useforpreciseelectrochemicalmeasurements,• useformulti-electrodepairconfigurations.Available with a new EPC 10 USB or as additional headstage to up-grade you EPC 10 USB patch clamp amplifier (revision “N” and later).

TIB 14 S Trigger InterfaceDigital output trigger interface with 14 TTL outputs and 14 open col-lector power outputs for switching valves directly. 14 switches allow manual control of the outputs.

EPS 16 Probe SelectorA headstage multiplexing device for connecting a patch clamp ampli-fier of the EPC 10 family to multiple headstages. The Probe Selector is available with up to 16 headstages.

TESC Model CellModel circuit simulating two electrodes measuring from the same cell.

PSA-12 USB tone generatorSound generator device for monitoring the seal resistance with EPC 9, EPC 10 amplifiers or ITC-16, ITC-18, LIH 1600, ITC-1600 interfaces.

Patch Clamp Amplifiers

EPC 7 PLUS Patch Clamp AmplifierManually operated Patch Clamp Amplifier. The classic instrument.

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Computer Controlled Amplifier

iTEV 90 Multi-Electrode Clamp AmplifierAmplifier system including three electrodes (Current, Voltage, Field-Compensation) with LIH 8+8 interface in one housing.

Oocyte Clamp Amplifiers

HEKAintroducesitsfirstfullycomputercontrolledOocyteClampAmplifiersystemiTEV90.Thisnewamplifierisfullydigitallycontrolledandprovidesautomatedtestandcalibrationroutines.TheiTEV90hastheLIH8+8interfacebuilt-inandisfullycontrolledbythePATCHMASTERsoftware.

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Computer Controlled Potentiostats / Galvanostats

The PG 300 USB family - Thefullycomputercontrolledpotentiostats/galvanostatsofthePG300fam-ilyarefullyintegratedwiththeLIH8+8A/DD/AdataacquisitioninterfaceandarereadytobeconnectedtoeitheraAppleorPCviaaUSB2.0hostinterface.

PG 310 USB Potentiostat/GalvanostatMax current ±2A, compliance voltage ±20V. Optional: External Preamplifier EPA for low noise current measurements < 100nA.

PG 390 USB Potentiostat/GalvanostatDesigned for low conductive electrolytes. Max current ±1A, compliance voltage ±90V.

PG 340 USB Bipotentiostat/Galvanostat2 independent working elec-trodes (RING, DISK). Max current ±2A at RING and DISK, compli-ance voltage ±20V. Optional: 2 External Preamplifiers EPA for low noise current measurements < 100nA.

Potentiostats / Galvanostats

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Computer Controlled Potentiostats / Galvanostats

Thesepotentiostats/galvanostatsdonothaveabuilt-indataacquisitioninterface.AllHEKAmanuallycon-trolledpotentiostats/galvanostatsincludeaserialinterfaceRS-232whichenablesdigitalremotecontrol.HEKAalsoprovidesthesoftwarePGMASTERforcontrolofthepotentiostats/galvanostatsfreeofcharge.

PG 410 Potentiostat/GalvanostatMax. current ±2A, compliance voltage ±20 V, 1 Digital Display for current or voltage, 2 precision potentiometers for adjusting initial potential / current.

PG 490 Potentiostat/GalvanostatDesigned for low conductive electrolytes, Max. current ±1A, compliance voltage ±90 V, 1 Digital Display for current or voltage, 2 precision potentio- meters for adjusting initial potential / current.

PG 510 Potentiostat/GalvanostatMax. current ±2A, compliance voltage ±20 V, 2 separate Digital Displays for current and voltage, Analog Scan Generator for poten-tiostatic and galvanostatic ramps.

PG 590 Potentiostat/GalvanostatDesigned for low conductive electrolytes, Max. current ±1A, compliance voltage ±90 V, 2 separate Digital Displays for current and voltage, Analog Scan Generator for potentiostatic and galvanostatic ramps.

Potentiostats / Galvanostats

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Accessories EPA External PreamplifierTo be used with a PG 310 USB or PG 340 USB for low noise measure-ments in current ranges 100 pA, 1 nA, 10 nA and 100 nA. The EPA works in potentiostatic and galvanostatic modes and provides an additional input for a low current working electrode.

HCB 50 High Current BoosterCan be used with all HEKA Potentiostats / Galvanostats and other third-party potentiostats for currents up to 50 A at 10 V, permanently shortcut protected.

HCB 20 High Current BoosterCan be used with all HEKA Potentiostats / Galvanostats and other third-party potentiostats for currents up to 20 A at 10 V, permanently shortcut protected.

ESG 10 Analog Scan GeneratorScan Generator for smooth analog voltage ramps without digital steps. 20 scan speeds can be selected in the range of 1 mV/s to 1000 V/s. The ESG 10 is manually operated, can be triggered and provides a scanning potential range from -10 V to +10V. Initial potential, first and second reversal potential can be adjusted.

TIB 14 S Trigger InterfaceDigital output trigger Interface with 14 TTL outputs and 14 open col-lector power outputs for switching valves directly. 14 switches allow manual control of the outputs.

CIP 2 Conductance InterfaceInterface box for conductance measurements using two poten-tiostats. The conductance can be measured during electropolymeriza-tion but can also be used in order to characterize the conductance of deposited polymers in relation to the applied potential.

MC 300 Model CellModel circuit for all HEKA Potentiostats/Galvanostats for current ranges from 1 μA to 10 A. The circuit includes different capacitors forming various Randle circuits. The cell can be used for verifying the potentiostat and for calibrating the current ranges for impedance measurements.

MC 300-LC Model CellModel circuit for the current ranges 100 pA, 1 nA, 10 nA, and 100 nA use with the external preamplifier EPA.

Potentiostats / Galvanostats

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EVA 8 Voltammetric AmplifierVoltammetric Amplifier for micro-electrode recording technology with Remote and Local Opera-tion Mode selectable.

Microelectrode Amplifiers

FormeasurementswithmicroelectrodesinthefieldsofElectrophysiologyandElectrochemistrywepro-videanamplifiersystemwithupto+/-2Vstimulusrangeandtheoptionofcapacitancecompensation.

Manually Controlled Amplifier

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AcquisitionInterfaces

HostInterfaceBoards

InstruTECH LIH 8+8 Data Acquisition InterfaceExpandable 16-bit multi-channel data acquisition interface for con-nection with a PC or Apple com-puter via a USB 2.0 interface. Providing four D/A outputs, eight A/D inputs, 16 digital inputs and 16 digital outputs, all inductively isolated.

InstruTECH ITC-18 Data Acquisition Interface16-bit data acquisition interface with four D/A outputs, eight si-multaneous sampling A/D inputs (each with a programmable gain amplifier), sixteen digital inputs and thirty-two digital outputs, all optically isolated.

InstruTECH ITC 1600 Data Acquisition InterfaceExpandable 16-bit multi-channel data acquisition interface for connection with a PC or Apple computer via a PCI host card interface.

Host Interfaces available for ITC-16 or EPC 9• PCI-16:5VoltPCIhostinterfacecardincludingRC-16cable• PCI-16V3:3.3VoltPCI/PCI-Xhostinterfacecardincluding RC-16 cable• USB-16:USB2.0hostinterfaceincludingRC-16/12andUSBcable

Host Interfaces available for ITC-18 or EPC 10 Plus• PCI-18:5VoltPCIhostinterfacecardincludingSC-18cable• PCI-18V3:3.3VoltPCI/PCI-Xhostinterfacecardincluding SC-18 cable• USB-18:USB2.0hostinterfaceincludingSC-18/12andUSBcable

Host interfaces available for ITC-1600, LIH 1600 or EPC 10• PCI-1600:PCI(3.3or5Volt)hostinterfacecard• PCI-1600e:PCIExpresshostinterfacecard

Acquisition Hardware

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Acquisition&Analysis

PATCHMASTER AcquisitionSoftwareforElectrophysiologyMulti-channel stimulation/acquisi-tion software with programmable experiment control and automa-tion, software Lock-In amplifier and Photometry extension. Support all HEKA amplifiers and data acquisition hardware.

POTMASTER AcquisitionSoftwareforElectrochemistryHighly flexible stimulation/acquisition software with scan generator, data acquisition and online analysis. Supports various electrochemical methods and gives the room for new user programmed methods.

EC_Tools Add on to Potmaster, freeofchargeUser-friendly masks for quick use of certain electrochemical methods and applications• CyclicVoltammetry• ImpedanceSpectroscopy• PittingCorrosion• PolarizationResistance• DifferentialPulseVoltammetry• NormalPulseVoltammetry• TastPulseVoltammetry• PotentialStepVoltammetry

Software

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FITMASTER AnalysisSoftwareAnalysis and fitting package optimized for data acquired with PATCHMASTER, CHARTMAS-TER or POTMASTER. • singlechannelanalysis• actionpotentialanalysisand event detection• fittingtouserdefined equations• powerspectraanalysis

CHARTMASTERMulti-purpose stimulation/ac-quisition software including pro-grammable experiment control and automation, software Lock-In and Photometry extension.

TIDA 8 ChannelAcquisitionSoftware8 channel data acquisition and analysis software. Running under Windows2000,XP

Acquisition&Analysis

Software

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PATCHMASTER PRO Multi-channelacquisitionsoftwarePATCHMASTER PRO is designed for experiment control, data acquisition and analysis in an GLP environment.

FITMASTER PRO AnalysissoftwareFITMASTER PRO can be used in combination with PATCHMAS-TER PRO for analysis of data acquired in an GLP environment.

GLPSoftware

Software

ThePROeditionofthePATCHMASTERandFITMASTERsoftwareisdesignedtosupportasetofGoodLabPractice(GLP)standardsfordataacquisitionandhandling,asestablishedbytheFoodandDrugAd-ministration(FDA)(21CFRPart11).

HEKAalsooffersservicesforpreparationofvalidationrelateddocumentationandservicesforInstallationQualification(IQ)andOperationalQualification(OQ).Additionalinformationcanbeprovidedonrequest.PleasecontactHEKAdirectly.

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EPCMASTERTo use fully computer controlled Patch Clamp Amplifiers in conjunction with a custom data acquisition system, we provide EPCMASTER for control of the amplifier functions.

PGMASTERTo use any of the PG 300 family of potentiostats / galvanostats in conjunction with a custom data acquisition system, we provide PGMASTER for control.

AdditionalSoftware

Software

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LIH_XOPsIGORProXOP’sforcontrollingInstruTECH data acquisition interfaces.

EPC DLLC-DLL to integrate HEKA amplifi-ers and data acquisition systems in your own software. Includes documentation and use of the support hotline.

Data AccessImport of PATCHMASTER and PULSE data to Sigma Plot, Microsoft Excel, Visual Basic, Origin and IGOR Pro.

TAC SingleChannelAnalysisPerform single-channel analysis of patch clamp recordings.• Kineticanalysisofrecordingsfromsingleionchannels• Eventidealizationthroughthresholddetection• Readscommonelectrophysiologyfileformats• ExperimentalHiddenMarkovMethodanalysis(HMM)

Igor Pro GraphingandDataAnalysisWorks and plots PATCHMASTER and PULSE data. For Windows and Mac OS.

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PIP 6 Pipette PullerTemperature controlled pipette puller with alignment tool for manufacturing of pipettes with identical length.

Pipette HolderThe HEKA pipette holders are available for glass capillaries with an outer diameter of 1.0, 1.3, 1.5, 1.7 and 2.0 mm.

Microelectrode HolderConnects microelectrodes or carbon fiber electrodes with a gold-plat-ed connector pin to the headstage of a HEKA amplifier. Holders for electrodes with outer diameters of 2.0 or 2.7 mm are available.

Pipette Puller

Holders

Pipette and Electrode Manufacturing

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Pt microdisk electrodeElectro_active diameter 1μm, 5 μm, or 10 μm.

MicroelectrodesThe sharp microelectrode with a standard length of 8 cm is based on a fiber with 80 μm outer diamteter and 25 μm diameter metal core, alloy of platinum/tungsten (Pt 90%/W 10%). The metal core is sur-rounded and isolated by quartz glass. The electrode fiber is contacted with a gold-pin and mounted in a glass capillary. The microelectrode can be directly connected to any preamplifier from HEKA using the HEKA microelectrode holder for electrodes with outer diameter of 2 mm. Available in two versions:• groundonly:Thetipisgroundsharplywithanimpedance < 1 MOhm at 1 kHz.• pulledandground:Thesmalltipispulledandgroundsharply with an impedance > 1 MOhm at 1 kHz.Other materials of the electroactive core are available on request.

Carbon Fiber MicroelectrodesManufactured with Anodic Electrophoretic Deposition of Paint (EDP) method. 5 μm diameter. Gold-plated pin connected, ready to use with HEKA Microelectrode Holder for electrode with outer diameter of 2.7 mm. Pack of 10 pcs.

Rotating Ring-Disk ElectrodeRotator for disk or ring-disk configurations and speed control unit to be used with the PG 340, electrodes with fixed Pt-ring and disk.

Electrodes

Pipette and Electrode Manufacturing

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ECC 7 ElectrochemicalCellComplete electrochemical cell including connections for a thermostat and for longterm experiments working under inert gas.

OSC 5 OpenSandwichCellComplete open electrochemical cell for electro-chemical applications in aqueous or organic elec-trolytes. The cell is especially designed for HEKA ElProScan systems.

Counter ElectrodeCounter Electrode of Platinum with Teflon body including one shielded electrode cable.

Pseudo Reference ElectrodeAg/AgCl pseudo reference electrode woth Teflon body for organic solvents including one shielded electrode cable.

Reference ElectrodeCalomel or Ag/AgCl reference electrode with Hager-Luggin capillary.

ElectrochemicalCells

ElectrodesforElectrochemicalCells

Electrochemical Cells

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Faraday CageStand-alone Faraday Cage, outer dimensions (H x W x D): (190 x 110 x 83) cm / (74.8 x 43.3 x 32.7) inches.

Front Door OptionUpgrade of the Faraday Cage with standard dimensions with two front doors.

Demountable Faraday Cage · Stand-alone Faraday Cage, outer dimensions (H x W x D): (190 x 100 x 100) cm / (74.8 x 39.4 x 39.4) inches. Parts are demountable to simplify transportation.

Demountable Large Faraday Cage · Stand-alone Faraday Cage, outer dimensions (H x W x D): (192,5 x 130 x 100) cm / (75.8 x 51.2 x 39.4) inches. Parts are demountable to simplify transportation.

Table Top Faraday CageThe Faraday cage has one front door which can be placed to the left or right side optionally. Cable ducts are provided from all sides. A contact strip for ground connectors is built-in. The cage has a massive base plate made of steel. Outer dimensions (H x W x D): (86 x 56 x 59) cm / (33.9 x 22.0 x 23.2) inches.

Faraday Cages

Electric Shielding

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ELP 10 - ElProScan HRXY:10nmresolutionadaptedtofit on inverted microscopeThe system contains all of the individual components previously listed with a positioning system offering 10nm resolution on all three motor axis and 3 nm with the additional Piezo on the z-axis.

ELP 11 - ElProScan HRSame as above but the position-ing system is adapted to fit on an inverted microscope.

TheElProScansystemprovidesmanyuniquefeatures:• Closed-loopcontrolforallaxis(X,Y,Z)andtheZ-Piezo• Easytouseautomaticcalibrationofthepositioningsystemandthebipotentiostat• Lownoiserecordingofverylowcurrentsbelow1pA• Integratedreal-timecomputersystemforrealconstantvelocityscansandreal-timeslopecompensation• Real-timecontrolledconstantdistancescanwithfullyintegratedshear-forceunit• 3D-Matrixscanwithfreelyprogrammedelectrochemicaltechniques• Templatescanoverde?nedplanarstructures

ElectrochemicalProbeScanner(SECM)

Complete Systems

TheHEKAElProScanisahigh-resolutionElectrochemicalProbeScannerwhichcanbeusedasaScanningElectrochemicalMicroscope(SECM).

Thetwoexamplesofdifferenthigh-resolutionElProScansystemsbelowdifferwithrespecttotheposi-tioningsystemandrequiredusagebythecustomer.Duetothefactthatthesesystemscanbepurchasedindividually,thereisroomforcustomizationofsystemstosuityourindividualrequirements.PleasecontactHEKAdirectly.

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SFU 3 ShearForceUnitforElProScanMeasures current less the height profile of structured samples. The SFU 3 upgrades the ElProScan systems to add the “constant distance” scan mode. The SFU 3 is also available as stand-alone version to be used with other SECM systems.

ElProScanOptions

Lipidbilayersareawidelyusedtooltoinvestigatemembraneproteinsinatailorablelipidenvironment.Comparedtotraditionalmethodsthebilayertechniqueisnotlimitedtocertaincelllinesandextendsthescopetosubcellularvesiclesandporeformingproteinslikesynucleinsortoxins.

Weareofferingabench-top-formatsystemandanewadd-onapproachtostandardinvertedmicroscopes.Thesystemsprovideaversatilesolutionthatsuitstheneedsinpharmacologicalresearch,drugdiscovery,andinacademia.

Ionovation CompactThe complete bilayer setup in a bench-top-format, highly automated and equipped with ccd-camera and objective, auto-perfusion, and all electri-cal compounds for membrane electrophysiology research.

Ionovation ExplorerThe innovative electro-optical setup with all electrical and mechanical compounds for high-content membrane electrophysi-ology research. The setup offers the combined observation of electrical and optical events on the membrane (spectroscopical compounds are available as an option).

Bilayer

Complete Systems

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SLP 40 SpatialLightPatternGeneratorIllumination and camera system for uncaging experiments in brain slices. Typical applications:• connectivitystudiesinacute slices of neuronal tissue• studiesofdynamicsignal integration in single cells• targetedreleaseofcaged compounds photo-bleaching

Complete Patch Clamp SetupHEKA offers customer specific completeset-up’sincludingsys-tem integration and installation.

LightPatternGenerator

PatchClamp

Complete Systems

Photo-activationofexcitablecellshasprovedtobeapowerfultooltostudyconnectivitypatternsinneu-ronalslicetissue.Inaconventionalmappingexperimentanintracellularrecordingfromasinglecellinthesliceisestablished.Thelightbeamisconsecutivelyfocusedontodifferentlocationswithinthesurround-ingtissue,elicitingspikesinthelocalcells.Thesespikescanbedetectedaspostsynapticeventsintheintracellularrecordingifafunctionalconnectionispresentwithinthetissue.Aconnectivitymapcanbegeneratedfromthelocationoflightirradiationandthepostsynapticresponsemeasurement.TheSLP40hasanextraordinarilywideprojectionrangeof3.6by5.2mmandallowsforanextremelyflexiblechoiceofstimulationparametersforeachpresynapticlocation.Inaddition,theSLP40canbeusedindynamicstimulationparadigmsand,optionally,upgradedforparallelstimulationofmultiplesites.

PatchClampingdivergesintomanydifferentapplicationsrequiringdiversehard-andsoftwaresolutions.Inordertofacilitatetheprocessofsettingupanewlaboratory,HEKAdesignscustomerspecificsolutions,integratingallrequireddifferenthardwaredevicesandsoftwaresystemstoacompleteset-up.

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HEKAissalespartnerofSutterinGermany,Austria,USA,CanadaandLatinAmerica.Theproductrangecovers:

Micromanipulators: Motorized 3-Axis Micromanipulator Systems (MPC-325, MPC-365, MPC-385, MP-225, MP-285), Huxley-Wall Style Manipulator System (MP-85), 3-Axis Manual Micromanipulator System (MM-33 / MM-33A), Miniaturized Micropositioners (MM-1 / MM-3)

Translators & Stages: MotorizedandManualXYTranslationSystemForFixed-StageMicroscopes(MT-2000,MT-1000),LargeMoving Stage And Fixed-Stage Platform (MT-78 / MT-78-FS)

Manipulator Stands: Manipulator Stands (MT-75 / MT-70 series), Micromanipulator Platforms (MD series)

Pipette Pullers and Bevelers: Laser Based Micropipette Puller - for quartz glass (P-2000), Next Generation Flamming/Brown Micropipette Puller (P-1000), Flamming/Brown Micropipette Puller (P-97), Vertical Micropipette Puller (P-30), Microelec-trode Beveler (BV-10)

Microinjection: Micromanipulators,DigitalMicroinjectorandAnalogMicroinjector(XenoWorks),PiezoImpactDrive(Prim-eTech PMM-150FU)

Imaging Products: WavelengthSwitcher(DG-5,DG-4),LightSources(LambdaXL,LambdaLS),FilterWheels(Lambda10-3,Lambda 10-2), Shutters (Smart Shutter)

HEKAisanofficialresellerforproductsmanufacturedbyALAScientific.Theproductrangecovers:

Patch Pipette Manufacturing: Microforge Coater/Polisher Systems (ALA-CPM-2)

Perfusion Systems: Gravity Driven Bath Perfusion Systems (VC3-PG4, VC3-PG8, VM-4PGTIB, VM-8PGTIB etc.), Pressure Driven Perfusion Systems (VC3-SP4, VC3-SP8 etc.), High Speed Solution Switcher (HSSE), Internal Pipette Perfusion System (2PK+), Various Perfusion Manifolds

Recording Chambers and Microincubators: various MS-type chambers, Temperature Controlled Chambers (HCMIS)

SUTTERINSTRUMENTCOMPANY-www.sutter.com

ALASCIENTIFICINSTRUMENTSINC.-www.alascience.com

Further Products

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Terms and Conditions Ordering information: We accept orders by fax, mail and e-mail. See our addresses or those of our resellers and distributors in “http://www.heka.com/worldwide/world.html#resellers”.

Prices: For countries without a regional exclusive distributor of HEKA products, prices are provided in both EURO and USD price lists. Customers ordering from the United States and South American countries, please refer to the USD Price List. Canadian customers please contact HEKA Electronics Inc. for quotations. All other customers please refer to our EURO Price List. Prices given in official quotations are valid for 3 months. All prices are subject to change without prior notice. All prices ex works are unit prices, carriage forward, not including value-added tax and applicable duties.

Payment: Payment terms are net 30 days. HEKA Electronics Inc. and HEKA Instruments also accept major credit cards, bank wire transfers and bank drafts drawn on U.S. or Canadian banks. For certain international sales, we will require documents against payment (D/P), i. e. a letter of credit (processing fee will apply), or payment in advance. In countries where we have local distributors, please contact them for individual sales conditions.

Shipping: Shipping charges are prepaid and added to our invoice. All products are usually sent door-to-door by air fright and courier. The carrier is selected by HEKA but can also be specified by the customer when placing an order.

Returns: HEKA items ordered in error may be returned within 30 days of receipt. A 15% restocking fee will be applied as well as any charges that may have been occurred to return the equipment to its original condition. The original packing material should be used. Please contact HEKA directly prior to any returns.

Warranty: HEKA provides a guarantee of one year from date of invoice to all instruments and labor. The warranty covers replacement of parts and labor to repair the product. The equipment must be returned to HEKA with pre-paid shipment. Return shipment is complementary. Technical service for and repairs of all instruments, if required, will be carried out directly by HEKA. The equipment must have been operated according to instructions provided in the user manual and any abuse, misuse or unauthorized repairs will void warranty conditions.

Software Support: Support is free of charge for owners of HEKA products.

Software Upgrade: HEKA has an unsurpassed policy regarding upgrades of its software! Upgrades of HEKA software (for PATCHMASTER, FITMASTER, POTMASTER, TIDA) are available to licensed holders free of charge. The latest version can also be obtained from our download page, or you can contact HEKA to receive our latest CD. When you purchase a copy of a software program, you purchase one license that is protected by a hardware key (“dongle”). We provide a discount for multiple licenses of our software as follows: 2nd and 3rd licences=20%; 4th or more=25%. This discount applies to HEKA software only and not to products from third parties.

Sales Support: We provide exceptional pre and post sales customer support from our trained international sales representatives. Customer support is free of charge for registered users of HEKA products.

Repair Policy: HEKA prides itself on its superb, long-standing repair and maintenance service of its hard-ware products. In fact we still offer support for the HEKA produced EPC 7 - also known as List amplifier - that was introduced back in 1982! Users have to cover all shipping costs to have the equipment shipped for repair and returned. HEKA will cover return costs if the repair is under warranty.

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General notice:Product names used herein are for identification purposes only and may be trademarks of their respective owners. HEKA disclaims any and all rights in those marks.

We reserve the right to effect technical changes as develop-ment progresses. Special ver-sions are available on request. Further technical data are pro-vided by a detailed description, which is available on request. A warranty of one year applies on all instruments.

Electrophysiology Electrochemistry

VK

RP

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HEKA ElektronikDr. Schulze GmbHWiesenstraße 71D-67466 Lambrecht/PfalzGermany

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