2018 sales data obtained from LePro PharmaCompass OPC Private

I1 I2 I3 I4 I5 I6 I7 I8 I9 10 11 12 13 14 15 16 17 18 19 20Humira Eliquis Revlimid Opdivo Enbrel Keytruda Herceptin Avastin Mabthera Xarelto Eylea Remicade Imbruvica Prevnar 13 Stelara Lyrica Genvoya Neulasta Tecfidera Ibrance(Adalimumab) (Apixaban) (Lenalidomide) (Nivolumab) (Etanercept) (Pembrolizumab) (Trastuzumab) (Bevacizumab) (Rituximab) (Rivaroxaban) (Aflibercept) (Infliximab) (Ibrutinib) (Pneumococcal 7-Valent

Conjugate)(Ustekinumab) (Pregabalin) (Elvitegravir, Cobicistat,

Emtricitabine, Tenofovir Alafenamide)(Pegfilgrastim) (Dimethyl Fumarate) (Palbociclib)

$20.467 Billion $9.871 Billion $9.685 Billion $7.566 Billion $7.45 Billion $7.171 Billion $7.051 Billion $6.917 Billion $6.819 Billion $6.58 Billion $6.545 Billion $6.442 Billion $6.205 Billion $5.803 Billion $5.25 Billion $5.216 Billion $4.624 Billion $4.475 Billion $4.274 Billion $4.118 Billion

21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40Lantus Lucentis Januvia Victoza Xtandi Botox Soliris Triumeq Zytiga Mavyret Trulicity Gilenya Advair Gardasil 9 Humalog Truvada Xolair Invega Sustenna Symbicort Cosentyx(Insulin Glargine) (Ranibizumab) (Sitagliptin) (Liraglutide) (Enzalutamide) (Onabotulinumtoxin A) (Eculizumab) (Abacavir, Dolutegravir &

Lamivudine)(Abiraterone Acetate) (Glecaprevir & Pibrentasvir) (Dulaglutide) (Fingolimod) (Fluticasone Propionate

& Salmeterol)(HPV 9-Valent Vaccine) (Insulin Lispro) (Emtricitabine &

Tenofovir Disoproxil)(Omalizumab) (Paliperidone Palmitate) (Budesonide & Formoterol) (Secukinumab)

$4.028 Billion $3.721 Billion $3.686 Billion $3.649 Billion $3.649 Billion $3.577 Billion $3.563 Billion $3.521 Billion $3.498 Billion $3.438 Billion $3.392 Billion $3.341 Billion $3.221 Billion $3.151 Billion $2.997 Billion $2.997 Billion $2.97 Billion $2.928 Billion $2.925 Billion $2.837 Billion

41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60Novolog Perjeta Spiriva Orencia Nexium Ocrevus Copaxone Interferon Beta-1A Jardiance Prolia Velcade Entyvio Sprycel Janumet Lipitor Actemra Tivicay Alimta Simponi Pomalyst(Insulin Aspart) (Pertuzumab) (Tiotropium) (Abatacept) (Esomeprazole) (Ocrelizumab) (Glatiramer Acetate) (Interferon Beta-1A) (Empagliflozin) (Denosumab) (Bortezomib) (Vedolizumab) (Dasatinib) (Metformin & Sitagliptin) (Atorvastatin) (Tocilizumab) (Dolutegravir) (Pemetrexed) (Golimumab) (Pomalidomide)

$2.814 Billion $2.8 Billion $2.725 Billion $2.71 Billion $2.399 Billion $2.376 Billion $2.366 Billion $2.363 Billion $2.308 Billion $2.291 Billion $2.283 Billion $2.276 Billion $2.275 Billion $2.228 Billion $2.207 Billion $2.181 Billion $2.179 Billion $2.133 Billion $2.084 Billion $2.04 Billion

61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80Darzalex Epclusa Prezcobix Aranesp Tasigna Tysabri Aubagio Tagrisso Cialis Dupixent Proquad Xgeva Prograf Sensipar Xeljanz Spinraza Cimzia Levemir Pradaxa Lovenox(Daratumumab) (Sofosbuvir & Velpatasvir) (Darunavir & Cobicistat) (Darbepoetin Alfa) (Nilotinib) (Natalizumab) (Teriflunomide) (Osimertinib) (Tadalafil) (Dupilumab) (Measles, Mumps, Rubella &

Varicella Virus Vaccine Live)(Denosumab) (Tacrolimus) (Cinacalcet) (Tofacitinib) (Nusinersen) (Certolizumab pegol) (Insulin Detemir) (Dabigatran) (Enoxaparin)

$2.025 Billion $1.966 Billion $1.955 Billion $1.877 Billion $1.874 Billion $1.864 Billion $1.861 Billion $1.86 Billion $1.852 Billion $1.812 Billion $1.798 Billion $1.786 Billion $1.784 Billion $1.774 Billion $1.773 Billion $1.724 Billion $1.717 Billion $1.679 Billion $1.679 Billion $1.655 Billion

81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100Latuda Plavix Otezla Odefsey Sandostatin Descovy Trajenta Forteo Gleevec Afinitor Relvar Crestor Novomix Farxiga Synagis Humulin Yervoy Brilinta TNKase Mirena Family(Lurasidone) (Clopidogrel) (Apremilast) (Emtricitabine, Rilpivirine &

Tenofovir Alafenamide)(Octreotide) (Emtricitabine &

Tenofovir Alafenamide)(Linagliptin) (Teriparatide) (Imatinib) (Everolimus) (Fluticasone Furoate) (Rosuvastatin) (Biphasic Insulin Aspart) (Dapagliflozin) (Palivizumab) (Insulin Isophane) (Ipilimumab) (Ticagrelor) (Tenecteplase) (Levonorgestrel)

$1.647 Billion $1.627 Billion $1.608 Billion $1.598 Billion $1.587 Billion $1.581 Billion $1.578 Billion $1.576 Billion $1.561 Billion $1.556 Billion $1.448 Billion $1.433 Billion $1.422 Billion $1.391 Billion $1.391 Billion $1.331 Billion $1.33 Billion $1.321 Billion $1.296 Billion $1.291 Billion

101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120Abraxane Myrbetriq Pulmicort Galvus Orkambi Restasis Benicar Vimpat Simponi Harvoni Opsumit Atripla Tresiba Biktarvy Novoseven Promacta Juvederm Tafinlar Isentress Acthar(Paclitaxel Protein Bound) (Mirabegron) (Budesonide) (Vildagliptin) (Lumacaftor & Ivacaftor) (Cyclosporine) (Olmesartan) (Lacosamide) (Golimumab) (Ledipasvir & Sofosbuvir) (Macitentan) (Efavirenz, Emtricitabine &

Tenofovir Disoproxil)(Insulin Degludec) (Bictegravir, Emtricitabine &

Tenofovir Alafenamide)(Coagulation Factor VII

[Recombinant])(Eltrombopag) (Hyaluronic Acid) (Dabrafenib & Trametinib) (Raltegravir) (Corticotropin)

$1.291 Billion $1.287 Billion $1.286 Billion $1.284 Billion $1.262 Billion $1.261 Billion $1.242 Billion $1.24 Billion $1.235 Billion $1.222 Billion $1.215 Billion $1.206 Billion $1.205 Billion $1.184 Billion $1.182 Billion $1.174 Billion $1.163 Billion $1.155 Billion $1.14 Billion $1.11 Billion

121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140Jadenu Chantix Hepatitis Sutent Shingrix Esbriet Abilify Maintena Entresto Faslodex Norvasc Diovan HCT Kyprolis Epogen Kalydeco Exforge Leuprorelin Kadcyla Procrit Ventolin Jakavi(Deferasirox) (Varenicline) (Vaccine) (Sunitinib) (Zoster Vaccine

Recombinant, Adjuvanted)(Pirfenidone) (Aripiprazole) (Sacubitril & Valsartan) (Fulvestrant) (Amlodipine) (Hydrochlorothiazide & Valsartan) (Carfilzomib) (Epoetin Alfa) (Ivacaftor) (Amlodipine & Valsartan) (Leuprorelin) (Trastuzumab Emtansine) (Epoetin Alfa) (Albuterol) (Ruxolitinib)

$1.099 Billion $1.084 Billion $1.074 Billion $1.049 Billion $1.042 Billion $1.041 Billion $1.031 Billion $1.028 Billion $1.028 Billion $1.025 Billion $1.023 Billion $1.012 Billion $1.01 Billion $1.008 Billion $1.002 Billion $999 Million $988 Million $988 Million $980 Million $977 Million

141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160Kogenate Somatuline Lumizyme Toujeo Letairis Taltz Creon Bridion Pneumovax 23 Pediarix Nuvaring Lupron Keppra Rexulti Vesicare Invokana Vectibix Lamictal Lixiana Zetia(Antihemophilic Factor

(Recombinant))(Lanreotide) (Alglucosidase Alfa) (Insulin Glargine) (Ambrisentan) (Ixekizumab) (Pancrelipase) (Sugammadex) (Pneumococcal Vaccine

Polyvalent)(Diphtheria, Tetanus

Acellular, & Pertussis)(Ethinyl Estradiol & Etonogestrel) (Leuprolide) (Levetiracetam) (Brexpiprazole) (Solifenacin) (Canagliflozin & Metformin) (Panitumumab) (Lamotrigine) (Edoxaban) (Ezetimibe)

$966 Million $956 Million $949 Million $949 Million $943 Million $937 Million $928 Million $917 Million $907 Million $904 Million $902 Million $892 Million $891 Million $883 Million $883 Million $881 Million $871 Million $864 Million $860 Million $857 Million

161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180Fabrazyme Lynparza Premarins Votrient Cyramza Edurant Samsca Nexavar Cerezyme Basaglar Flovent Linzess Tecentriq Bexsero Synthroid Symdeko Avodart Augmentin Ranexa Zoladex(Agalsidase Beta) (Olaparib) (Conjugated Estrogens) (Pazopanib) (Ramucirumab) (Rilpivirine) (Tolvaptan) (Sorafenib) (Imiglucerase) (Insulin Glargine) (Fluticasone Propionate) (Linaclotide) (Atezolizumab) (Meningococcal Vaccine) (Levothyroxine) (Tezacaftor & Ivacaftor) (Dutasteride) (Amoxicillin & Clavulanate) (Ranolazine) (Goserelin)

$853 Million $834 Million $832 Million $828 Million $821 Million $816 Million $810 Million $804 Million $803 Million $801 Million $791 Million $785 Million $779 Million $776 Million $776 Million $769 Million $760 Million $758 Million $758 Million $752 Million

181 182 183 184 185 186 187 188 189 190 191 192 193 194 195 196 197 198 199 200Nucala Pulmozyme Baraclude Noxafil Risperdal Consta Aprovel Adempas Rotateq YAZ Nplate Tarceva Seloken Cymbalta Singulair Glucobay Nexplanon Fluarix Rotarix Adalat Boostrix(Mepolizumab) (Dornase Alfa) (Entecavir) (Posaconazole) (Risperidone) (Irbesartan & Hydrochlorothiazide) (Riociguat) (Rotavirus Vaccine) (Drospirenone & Ethinyl Estradiol) (Romiplostim) (Erlotinib) (Metoprolol Hydrochloride) (Duloxetine) (Montelukast) (Acarbose) (Etonogestrel) (Influenza Vaccine) (Vaccine) (Nifedipine) (Diphtheria, Tetanus

Acellular, & Pertussis)

$748 Million $746 Million $744 Million $742 Million $737 Million $736 Million $731 Million $728 Million $722 Million $717 Million $714 Million $712 Million $708 Million $708 Million $703 Million $703 Million $695 Million $692 Million $690 Million $687 Million

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Top 200 Pharmaceutical Products by Retail Sales in 2018Produced by the Njarðarson Group at The University of Arizona