Probabilistic functional maps of human

subcortical structures

Probabilistic functional maps of human

subcortical structures

Wieslaw L. Nowinski, DSc, PhDBiomedical Imaging Lab, Institute of Bioengineering, Singapore

Alim Louis Benabid, MD, PhDUniversity of Joseph Fourier School of Medicine, Grenoble, France

www.ibe.a-star.edu.sg

www.cerefy.com

- BIL Neuroinformatics R&D roadmapBIL Neuroinformatics R&D roadmap

- About brain atlasAbout brain atlas- atlas definitionatlas definition

- atlas applicationsatlas applications

- Anatomical brain atlases and applicationsAnatomical brain atlases and applications

- Probabilistic functional mapsProbabilistic functional maps- source datasource data

- constructionconstruction

- Functional atlas applicationsFunctional atlas applications- neuroscience researchneuroscience research

- Internet portal for functional neurosurgeryInternet portal for functional neurosurgery

BIL Neuroinformatics R&D roadmap

BIL Neuroinformatics

RegistrationBrain

segmentation

Braindatabasing

Human brain atlases

Atlas-basedapplications

- Stereotactic and functional neurosurgeryStereotactic and functional neurosurgery

- Human brain mappingHuman brain mapping

- NeuroradiologyNeuroradiology

- NeuroeducationNeuroeducation

- Neurosurgical trainingNeurosurgical training

- Analysis of brain imagesAnalysis of brain images

- Neuroscience researchNeuroscience research

- Drug testingDrug testing

- Gene expression mappingGene expression mapping

- Laymen educationLaymen education

Medtronic/Sofamor Danek’s Stealth Station

Brain LAB’s Target

Atlas

Cerefy

inside

Products

Cerefy brain atlas Stereotactic and functional neurosurgery (5 products) (130 surgical workstations; 1,500 clinical individuals)

Cerefy brain atlas Stereotactic and functional neurosurgery (5 products) (130 surgical workstations; 1,500 clinical individuals)

SurgiPlan Elekta (Sweden)

SNN3 IGS SNN/Cedara (Canada)

NeuroMate ISS (USA/France)

Electronic Brain Atlas Library

Brain Atlas Geometrical Models

Cerefy Probabilistic Functional Atlas

Cerefy SFN Portal

Atlas

Cerefy

inside

Products

Cerefy Neuroradiology Atlas

(430 subscribers from www.cerefy.com)

Mayo’s Analyze

Cerefy brain atlasBrain mapping, neuroradiology, neuroeducation (4 products)

Cerefy brain atlasBrain mapping, neuroradiology, neuroeducation (4 products)

Cerefy Student Brain Atlas

The Cerefy Atlas of Brain Anatomy (450 copies)

- sparse atlas plates constructed from a few specimens only

- atlases are anatomical while the stereotactic targets are functional

constructed from electrophysiological and neuroimaging data

reconstruct 3D data from projections

normalize contact data

select best contacts

voxelize contacts

calculate atlas (best contact frequency)

compute probability

- Neuroscience research

- Stereotactic and functional neurosurgery

Probabilistic functional atlas overcomes several limitations of the current anatomical atlases

Facilitates knowledge discovery

Paradigm shift from manufacturer-centric to community centric