Principles of Neural Science Discussion Section

Lauren Walker

walkerl@wustl.edu

Office Hours: Thursday 5:30-6:30

Life Sciences 111

Contralateral Neglect Syndrome

Neuroscience. Purves et al. 2nd edition

Capgras Delusion

• Delusion that a loved one has been replaced by an identical- looking imposter

• Mrs. D, a 74 year old married housewife, believed “that her husband had been replaced by another unrelated man. She refused to sleep with the impostor, locked her bedroom and door at night, asked her son for a gun, and finally fought with the police when attempts were made to hospitalise her. At times she believed her husband was her long deceased father. She easily recognised other family members and would misidentify her husband only.”

Passer and Warnock 1991

Upcoming Seminars

• John D. York, Ph.D.

– Inositol phosphate Communication: insights into the Cell's 'iPhone’

– Wednesday, Sept 14 @ 4, Moore Auditorium

• Andrew Schwartz, Ph.D.

– "Progress Toward a High-performance Brain-controlled Prosthetics“

– Friday, Sept 16 @ 4, FLTC Connor Auditorium

Other terms

• Rostral- ‘towards the head’

• Caudal- ‘towards the tail’

– Caudal=tail

• Medial- ‘towards the middle’

• Lateral- ‘towards the side’

Famous Neuroscientists

Camillo Golgi Santiago Ramon y Cajal

Camillo Golgi • Silver nitrate staining

labels limited number of neurons at random

• Reticular theory

Santiago Ramon y Cajal

• Neuroanatomical studies

• Neuron Theory

• Realized nerve conduction had a ‘direction’

Llinas 2003 Nature

Neurons come in all shapes and sizes

http://www.mind.ilstu.edu/curriculum/neurons_intro/neurons_intro.php

Glia

Macroglia Astrocytes

Oligodendrocytes/ Schwann Cells

Microglia Macrophage-like

Astrocytes

Haydon 2001 Nat. Rev. Neurosci.

• Wrap synaptic terminals, associate w/neurons

– Modulate synaptic transmission

• Support endothelial cells of blood brain barrier

• Maintain ionic milieu

• Neurotransmitter uptake (Glu, GABA)

• Repair damage to CNS (glial scar)

• Connected by gap junctions

Calcium signaling in astrocytes

Fields 2010 Sci. Signal.

Myelin

Poliak and Peles 2003 Nat Rev Neurosci

Myelin

Microglia

• Scavenge CNS for damaged neurons and microbes

In your neuroscience textbook:

http://www.sinauer.com/neuroscience4e/animations22.1.html