Principles of Immunology

Autoimmunity4/25/06

Organs Specific Autoimmune Diseases

Hashimoto’s thyroiditis DTH like response to thyroid Ags Ab to thyroglobulin Hypothyroidism

Pernicious anemia Ab to gastric parietal cells Interferes with vitamin update Reduced RBCs

Organs Specific Autoimmune Diseases

Goodpasture’s syndrome Ab to Ag on basement membranes C activation Glomerulonephritis, pulmonary disease

Type 1 diabetes Ab to beta cells of pancreas DTF reaction Cytokine induced damage

Organs Specific Autoimmune Diseases

Myasthenia gravis Ab to acetyl choline receptors Blocks muscle activation C activation and damage to muscle cells

Systemic Autoimmune Disease

SLE Ab to certain tissue antigens Vasculitis Diagnosis using anti nuclear antibodies

MS Reaction to myelin sheath Viral component?

Systemic Autoimmune Disease

Rheumatoid arthritis IgM which is anti IgG Immune complexes Chronic inflammation

Genetics vs. Environment

HLA type Sequestered antigens

CD4 Cells and Autoimmune Disease

Transferable Anti CD4 Ab protective

Mechanisms

Release or expression of Ags Cross reacting Ags

Therapies

Cyclosporin Interferes with T cell development Anti-inflammatories