“Primum non nocere!”Hipokrat, 460-377. god. pre nove ere

Schematic pedigree diagram showing the main routes for biological transmission of the effects of exposure to the next

generation(s). Left, female line; right, male line

Pembrey M, et al. J Med Genet. 2014;51:563–72.

Mellor J. Biochemist. 2010;32(5):6-7.

Main components of the epigenetic code

Epigenetic mechanismare afected by these factors and proceses: ● Development (in utero, childhood) ● Environmental chemicals ● Drugs ● Aging ● Diet

Health endpoints● Cancer ● Autoimmune disease ● Mental disorders ● Diabetes ● Obesity● Allergy

Proteinsko-kalorijski deficit

Deficit gvožđa i cinka

Negativan bilans kalcijuma

Hipovitaminoza B12 i D

Deficit derivata alfa-linolenske kiseline (omega-3 LCPUFA)

Posledice vegetarijanske

i makrobiotičke ishrane u dečjoj dobi

Committee on Nutrition, American Academy of Pediatrics. Pediatric Nutrition Handbook, 6th ed. Elk Grove Village, IL:AAP; 2009: 201-24.

Di Genova T, Guyda H. Paediatr Child Health. 2007;12(3):185-8. Schürmann S, et al. Eur J Nutr. 2017 Mar 15.