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Previous models Human CAR + T cells (allo/xenogeneic, polyclonal) TCR MHC I CAR Ag IFNγR IFNγ Human cancer cells Mouse stroma cell MHC I TCR Ag CAR IFNγ IFNγR Current model Mouse CAR + T cells (non-specific, monoclonal) TCR MHC I CAR Ag IFNγR IFNγ Human cancer cells Mouse stroma cell MHC I TCR Ag CAR IFNγ IFNγR A B Interaction No interaction

Previous model s

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A. Previous model s. Human CAR + T cells ( allo/xenogeneic , polyclonal). Mouse stroma cells. Human cancer cells. MHC I. TCR. TCR. MHC I. Ag. CAR. CAR. Ag. IFNγR. IFNγ. IFNγR. IFNγ. B. Current model. Mouse CAR + T cells (non-specific, monoclonal). Mouse stroma cells. - PowerPoint PPT Presentation

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Page 1: Previous model s

Previous models

Human CAR+ T cells(allo/xenogeneic, polyclonal)

TCRMHC I

CARAg

IFNγR IFNγ

Human cancer cells Mouse stroma cells

MHC ITCR

AgCAR

IFNγ IFNγR

Current modelMouse CAR+ T cells(non-specific, monoclonal)

TCRMHC I

CARAg

IFNγR IFNγ

Human cancer cells Mouse stroma cells

MHC ITCR

AgCAR

IFNγ IFNγR

A

B

Interaction No interaction

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