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Table of Contents

Larger Cover

September 1, 2009

Volume 81, Issue 17

Pages 7127-7514

In this issue:

● Editorial

● Research Profile

● AC Detective

● Features

● Accelerated Articles

● Articles

● Technical Notes

● Correspondence

About the Cover:

The field of nanofluidics is maturing, and nanoscale lab-on-a-chip analyses are becoming more routine. Michelle L. Kovarik and

Stephen C. Jacobsen of Indiana University describe how the unique behavior of matter at the nanoscale adds new functionality

to devices that integrate nanopores or nanochannels. The cover shows a schematic of single-molecule fluorescence in a

nanochannel, a schematic of resistive-pulse sensing using a nanopore, and a histogram of photon bursts for single-molecule

fluorescence measurements of a DNA mixture. View the article.

indicates the article is freely available through sponsorship by the author or related funding agency. More about this program.

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Soft and Molecular Surfaces

Royce Murray

p 7127

Publication Date (Web): August 10, 2009 (Editorial)

DOI: 10.1021/ac901752x

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Research Profile

SERS enters the art scene

Katie Cottingham

p 7128

Publication Date (Web): August 10, 2009 (Research Profile)

DOI: 10.1021/ac901678f

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A simple grating-based instrument for spectral microscopy

Nancy D. Lamontagne

p 7129


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Molecule counting made easy

Erika Gebel

pp 7130–7131


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AC Detective

The mercury mystery of South America

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p 7132

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Features

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Protein Quantification in Complex Mixtures by Solid Phase Single-Molecule Counting

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Abstract | Supporting Info



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Nanocapillaries for Open Tubular Chromatographic Separations of Proteins in Femtoliter to

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Aptamer-Based Microfluidic Device for Enrichment, Sorting, and Detection of Multiple

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Surface-Enhanced Raman Spectroscopy: A Direct Method to Identify Colorants in Various

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Green Tape Technology

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Detection and Quantitation of IgG 1 Hinge Aspartate Isomerization: A Rapid Degradation in

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Isotope Dilution Method for Determination of Polybrominated Diphenyl Ethers Using Liquid

Chromatography Coupled to Negative Ionization Atmospheric Pressure Photoionization

Tandem Mass Spectrometry: Validation and Application to House Dust

Mohamed Abou-Elwafa Abdallah, Stuart Harrad and Adrian Covaci

pp 7460–7467


DOI: 10.1021/ac901305n


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Noncompetitive Fluorescence Polarization Aptamer-based Assay for Small Molecule

Detection

Josephine Ruta, Sandrine Perrier, Corinne Ravelet, Jennifer Fize and Eric Peyrin

pp 7468–7473


DOI: 10.1021/ac9014512

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Influence of a Magnetic Nanoparticle As a Drug Carrier on the Activity of Anticancer Drugs:

Interactions of Double Stranded DNA and Doxorubicin Modified with a Carrier

Anna M. Nowicka, Agata Kowalczyk, Mikolaj Donten, Pawel Krysinski and Zbigniew Stojek

pp 7474–7483


DOI: 10.1021/ac9014534

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Technical Notes

Aptamer-Linked Assay for Thrombin Using Gold Nanoparticle Amplification and Inductively

Coupled Plasma−Mass Spectrometry Detection

Qiang Zhao, Xiufen Lu, Chun-Gang Yuan, Xing-Fang Li and X. Chris Le

pp 7484–7489

Publication Date (Web): August 11, 2009 (Technical Note)

DOI: 10.1021/ac900961y


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High-Throughput Profiling of Formalin-Fixed Paraffin-Embedded Tissue Using Parallel

Electrophoresis and Matrix-Assisted Laser Desorption Ionization Mass Spectrometry

Hans-Rudolf Aerni, Dale S. Cornett and Richard M. Caprioli

pp 7490–7495


DOI: 10.1021/ac900974j


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Fabrication and Characterization of a Dual Submicrometer-Sized Electrode

Chenxi Yang and Peng Sun

pp 7496–7500

Publication Date (Web): July 29, 2009 (Technical Note)

DOI: 10.1021/ac901099n

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Half-Life Mapping of Nitroxyl Radicals with Three-Dimensional Electron Paramagnetic

Resonance Imaging at an Interval of 3.6 Seconds

Hideo Sato-Akaba, Yoko Kuwahara, Hirotada Fujii and Hiroshi Hirata

pp 7501–7506

Publication Date (Web): July 31, 2009 (Technical Note)

DOI: 10.1021/ac901169g

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Scattering Imaging of Single Quantum Dots with Dark-Field Microscopy

Xiaobing Bu, Huaping Chen, Hongwei Gai, Ronghua Yang and Edward S Yeung

pp 7507–7509


DOI: 10.1021/ac901410w

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Correspondence

Antibody−Antigen Exchange Equilibria in a Field of an External Force: Design of Reagentless

Biosensors

Christopher F. Monson, Laura N. Driscoll, Eliot Bennion, Cary J. Miller and Marcin Majda

pp 7510–7514

Publication Date (Web): July 29, 2009 (Correspondence)

DOI: 10.1021/ac9010759

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