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Director’s Report Amit Acharya, B.D.S., Ph.D.  Execu ve Director 

3 MCRI Welcomes New Staff Welcometoallournewemployees!

Iwasprobably12yearsoldwhenIlostaveryclosefamilymemberduetocancer.IrememberveryclearlythepainourfamilywentthroughandallthequestionsthatIhadthatwereunanswered.Threedecadesago,grow-ingupinadevelopingcountrymeantmyfamilydidnothavemanyoptionsavailableformedicalcareandtechnology.Thiswasthemomentmyjourneybegan-Iwantedtomakeadifferenceinhowhealthcareisdeliveredandhelppeopleandtheirfamilies.

IamsoproudtobepartofanorganizationlikeMCHSwhereresearchisanintegralcomponentofcaredeliveryandtheestablishmentoftheCancerCareandResearchCenter(CCRC)asthenewestcenterisatestamenttothisvalue.Wehavehadalotofvisionarieswhohaveworkedtirelesslyoverthedecadesforustorealizethismilestone.Iamsothank-fulforallthemandthemanystaffacrossMarsh ieldClinicandMCRIwhomadethispossible.Integrationoftheoncologyresearch/treatmenttrialsaspartofourroutinecaredeliveryisveryimportantassometimesthesevaluabletreatmentoptionsmightbethelastchanceforourpatientswhoare ightingcancer.

TheNationalCancerInstitutebelievesthemosteffectivemodeltoadvancecancercareisonethatincludescare,research,cancercontroland

March2018

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A Publica on Milestone Dr.JosephMazzareaches150peer-reviewedpublications.

8 Intro to Case Reports Tipsforwritingastellarcasereport.

9

Final Common Rule Delay Anupdateontheplannedchangeforhumanresearchprotectionpolicy.

11 Giving Back Holidaysinspireopportunitiesforsupportingthecommunity.

12 Lunch and Learn TheORCAteamintroducesaneweducationseries.

populationhealthinonelocation.TheestablishmentofCCRCwillembracethatcomprehensiveapproach.Marsh ieldClinichasalongtraditionofprovidinghighqualityoncologycareinthemanycommunitiesitserves.TheCCRCwillensureourpatientshavecontinuedaccesstothelatestdiagnosticandtreat-mentoptionsbyprovidingcomprehensiveresearchsupportservicesforpatientsatlocalandregionalcenters.Itisexpectedthatourintegratedclinicalcareandresearchinfrastructurewillattractnationallyrenownedoncologyresearcherstojoinourorganiza-tionandfurthergrowoncologyresearchintheepidemiological,translationalandhealthserviceresearcharena.

IamhappytoannouncethattheMCRISharedServicesleadershipteamhasbeenestablishedandstartedmeetingregularlytobeginaddressingourprocessesandpoliciesastheyassessthequalityofservicesdelivered,identifyopportunitiesforimprovement,anddevelopanopencommunicationplan.TheOf iceofResearchComputingandAnalytics(ORCA)ledbyMr.JoeEllefsonhasinitiatedmeetingwiththecenterleadershiptofurtherunderstandingoftheirresearchsupportneeds.JoeandhisteamsarealsodevelopingthemanyprocessesandpoliciessupportingtheHubandSpokemodelofservicesthatwehaveembarkedon.TheIntegratedResearchandDevelopmentLab(IRDL)ledbyDr.JenMeececontin-uestoprovideahighqualityofservicetothevariousresearchprojectsacrossMCRIandMarsh ieldClinic.TheOf iceofResearchSupportServices(ORSS)recentlywelcomedMrs.JordonOttasitsDirector.Mostrecently,JordonservedastheDirector,Of iceofExtramuralSupportatUniversityofWisconsin-Extension(UWEX)inMadisonsinceFebruary,2014. 

AtUWEX,Jordondirectedcentrallyorganizedadmin-istrative,business, and inancialfunctionsrelatedtoawardadministrationforUWEXwithover$38mil-lioninextramuralfundsreceivedinFY2016.IamalsohappytoannouncethatMarsh ieldClinicHealthSystemwasrecentlygrantedFullRe-Accreditationfor iveyearsbytheAssociationfortheAccreditationofHumanResearchProtectionsPrograms(AAHRPP).Accreditationisapublicaf irmationofourcommit-menttoprotectingresearchparticipants.IamverythankfulforthemanystafffromORSSandothersacrossMCRIandMarsh ieldClinicwhohelpedwiththisprocess.

IwantedtoremindeveryoneabouttheopportunityweallhavetobeearlyparticipantsintheNationalInstitutesofHealth’sAllofUsResearchProgram,anambitiousefforttoadvanceresearchinprecisionmedicinebyrecruitingonemillionindividualsacrosstheUnitedStatesfromallwalksoflife.Thislandmarkprogramwillhelpbuildthelargesthealthdatabaseofitskind,andMCRIisproudtohavebeenchosenasoneofseveralorganizationstoparticipate.Ifyouareinterestedinlearningmore,pleaseviewtherecentPulseStorydescribingtheinitiative.Youmayalsoexpressinterestorgetmoreinformationbyemailingtheprogramatallofus@marsh ieldresearch.org,orcalling888-633-9987.ByjoiningAllofUs,youcanhelpshapethefutureofhealthforgenerationstocome.Ideeplybelieveintheresearchmissionofourhealthsystemandfeelstronglyaboutcontributingtoscienceinmorethanoneway.IrecentlyenrolledintheAllofUs‐Wisconsininitiativeduringitsinitialpilotphaseofrecruitmentanditwasaveryful illingexperience.IcanproudlysaythatIam‘oneinamillion’.

Marshfield Clinic Health System receives AAHRPP Re‐accredita on   

InDec.2017,Marsh ieldClinicHealthSystemwasgrantedFullRe-Accreditationfor iveyearsbytheAssociationfortheAccreditationofHumanResearchProtectionsPrograms(AAHRPP).Accreditationindicatesthatourinstitutionfollowsrigorousstand-ardsforethics,qualityandprotectionsforhumanresearch.Marsh ieldClinicHealthSys-tem’sresearchparticipants,ourpeers,sponsorslookingforsites,governmentagenciesandthegeneralpubliccanbereassuredknowingthatwehaveat-tainedthehighestlevel.TheAAHRPPseal,placesusamongtheworld’smostrespected,trustworthyresearchorganizations.

MCRI Welcomes New Staff 

Holly Voll 

HollyVolljoinedSponsoredProgramsonJanuary8asaGrantsandContractsSpecialist.Shereceivedherbachelor’sdegreefromtheUniversityofWisconsin-EauClaireandherMasterofArtsdegreefromtheUniversityofWisconsin–StevensPoint.Ms.Voll’scareerhasincluded27yearsingrantsandfundraisingdevelopmentandJournalism.ShepreviouslyworkedfortwooftheUWSystemuniversitiesaswellassocialserviceorganiza-tionsincludingtheAmericanDiabetesAssociation,MarchofDimesandtheAmericanCancerSociety.Ms.VollismarriedtoChrisandhastwodaughters,oneofwhomisafreshmanatUW-Milwaukee.Sheandherfamilyenjoycamping,cross-countryskiingandattendingconcerts. 

 

 

Dawn Barker 

DawnBarkerhasacceptedtheResearchCoordinatorAssociatepositionwiththeClinicalResearchCenter,effectiveNovember27th.ShewillbelocatedinourEasterndivision,primarilyattheWestoncenter.DawnisarecentgraduatefromWaldenUniversity,withabachelordegreeinhealthstudies.ShehasalsoheldaMedicalAssistantcerti icationsince1998.Dawn’s irstprioritywillbetotrainandworkontheupcomingCepheidRSV/Flutrial.

Kellie Haws  

 

 

KellieHawsjoinedtheClinicalResearchteamasaClinicalTrialsAssistantonJanuary8th.Kelliewillbe100%fundedbyDr.Haws’BBSgrant,andshehasalreadybegunshadowingCassidySalsberyonmanyofthedutiesthatshewillbeassistingwith.Fornow,KelliewillbesittinginwithKristinaFlettyuntilamoreperma-nentlocationisset.You’llseeKellieherearound20hoursperweek.

Margaret Carder 

MargaretCarderhasacceptedatemporaryResearchCoordina-torAssociatepositionwiththeClinicalResearchCenterNovember27th.ShewillbelocatedinourEasterndivision,workingwithDawnBarkerontheupcomingCepheidRSV/FlutrialinWausau.Margaretgrad-uatedin2013fromtheClinicalResearchCoordinatorprogramatMid-StateTechnicalCollegeinWisconsinRapids.ShealsohasherbachelordegreeinHealthcareManagementfromLakelandUniversityinPlymouth,WI.MargarethasexperienceinterninginclinicalresearchdepartmentsatMarsh ieldClinicandAspirusHeartandVascularInstitute,wheresheobservedandassistedResearchCoordinatorswithclinicaldrugtrials.Shehelpedwithtaskssuchascompletingcasereportforms,analyzingEMR’sforpotentialresearchsubjectsthatmetinclusion/exclusioncriteria,andobservinginitialandfollow-upvisitswithresearchparticipants.ThisexperiencewillserveherwellasshestepsintohernewrolewithCRC.

Jus n Jordan 

 

 

 

 

 

JustinJordanjoinedMCRIonNovember27thasaFinancialAnalystinAccounting-GrantsandGifts.HereceivedhisBBAinFinanceandBAinEconomicsfromSouthernMethodistUniversityinDallas,Texas.Mr.JordanpreviouslyworkedasanAssistantVicePresidentinSpecialAssetManagementatCenterlineCapitalGroupinDallas,TexaspriortojoiningMCRI.Inhissparetime,Mr.Jordanrefereescollegefootballandspendstimewithhiswife,aswellashistwoShar-Peis.

Tommy Trzebiatowski 

TommyjoinedORCAasaProgrammer/AnalystonMarch5th.Hisprofessionalcareerbe-ganbackinLaCrossewherehewasattendingUW-LaCrosse.HewasaninternatReinhartFood-service,LLCforayear.HealsohadayearlonginternshipatSkywardinStevensPoint,Wis-consin,followedby8monthsoffull-timeemploymentaftercol-lege.TommyhasaBSMajorinComputerScienceandaminorinMathematics.Hehassincespentthepast2yearsatMCIS–nowMCHSIS.

Hisinterestsbasicallyrevolvearound2things:poolandpro-gramming.Hedoesbothofthemalmosteverydayinhissparetime.Healsoco-ownsafran-chiseoftheAmericanPoolplay-ersAssociation(APA)poolleaguewhichcurrentlyhas3divisionsofplay:Marsh ield,WisconsinRapids,andNeills-ville.Theseactivitieskeephimprettybusymostnightsoftheweek.

 

Tolulope Bello  

TolulopeBellorecentlyjoinedOncologyResearchonJanuary22asaResearchCoordinatorAssociate.TolulopemovedtoWisconsinfromFloridaandcomestouswithaMaster’sdegreeinPublicHealthfromUniversityofSouthFloridaandhasrecentexperienceinWell-nessandSafetyeducationprovidingbedsideeducationtopatientsinahealthcaresettingandpreviouslyasagraduateresearchassistantatUSF,collegeofpublichealth.

Melissa Hileman  

 

 

 

 

 

MelissaHilemanrecentlyjoinedOncologyResearchonJanuary22asaResearchCoor-dinatorAssociate.MelissaisaninternaltransferfromthePharmacy-SeniorPharmacyTechnicianandsheholdsaBachelorofScienceDegreeinBiologywithaminorinEnviron-mentalSciencefromtheUniver-sityofWisconsinMadison.Shewillbebringingagreatdealofknowledgetoourteam.

Sarah Gamillo 

 

 

 

 

 

SarahGamillojoinedOncologyResearchonDecember18th,asaResearchCoordinatorAssociate.SarahcomestoMCRIwithaBachelorofScienceDegreefromUWStevensPointwithaMajorinHealthScience-PrePTandaMinorinPsycholo-gy.Shehaspriorexperienceintelephonecommunicationandcustomerservice.

Anne Edwards  

AnneEdwardshasacceptedaResearchCoordinatorAssoci-atepositionwiththeCenterforHumanGeneticsAllofUsResearchProject.AnnehasAssociateDegreesinAppliedScience(ClinicalResearch)throughMid-StateTechnicalCollegeandGeneralStudiesthroughtheUW-Marsh ield/WoodCounty.Shedevelopedaninterestinresearchasastudentwhenfamilymembersbene itedfromclinicalresearchstudies.AnnepreviouslyworkedasanOccupationalHealthServicesCoordinatoratMarsh ieldClinicandinvariousresearchcoordi-natorpositionsforthepastfouryearsbeforejoiningtheCenterforHumanGenetics.Inhersparetime,Anneenjoysreadingbooksandspendingtimewithherthreedaughters.

Ariel Marcoe 

ArielMarcoehasjoinedtheCenterforHumanGeneticsAllofUsResearchProjectteamasaResearchCoordinatorAssociate.Shewillalsobeprovidingassistanceonaninter-nallyfundedprecisionmedicineproject.Arielrecentlygraduat-edfromtheUniversityofWisconsin–StevensPoint(UWSP)withanundergraduatedegreeinBiology.Asanunder-graduatestudentduringthesummerof2016,ArielcompletedaScienti icWritinginternshipwiththeCenterforOralandSystemicHealthinpartnershipwithUWSP.Ariel’spositiveinternshipexperienceledhertoapplyforaresearchcoordinatorpositionatMarsh-ieldClinicResearchInstitute.Herpastworkexperienceincludesworkingon lu/RSV,Lymediseaseandblastomycosisstudies.Whensheisnotwork-ing,Arielenjoysdoingartprojectsandreading.

Shicheng Guo, PhD 

ShichengGuo,PhDjoinedtheCenterforHumanGeneticsasaPostdoctoralFellow-ResearchundertheguidanceofAssociateResearchScientist,StevenSchrodi,PhD.Dr.Guoreceivedhisundergraduatede-greefromtheSchoolofLifeSci-ences,NortheastAgriculturalUniversity,Harbin,China,andhisdoctorateinHumanGeneticsfromFudanUniversity,Shang-hai,Chinain2015.Shichengcompletedpost-doctrainingattheUniversityofTexasHealthSciencesCenterinHouston,Tex-as,andtheUniversityofCalifor-nia,SanDiego,beforejoiningtheCenterforHumanGenetics.Dr.Guohasauthored38high-impactpublicationsandfore-seesdevelopingnewstatisticalmethodstoidentifydisease-susceptibilitygenesusingGe-nome-WideAssociation/Exome-sequencingdata.Inhissparetime,Dr.Guoenjoys ishing,touring,andcookingChinesefood.

MCRI On The Move  Jordyn Dieman  

JordynDiemanhasacceptedatemporaryRCApositionwiththeClinicalResearchCenter–MultispecialtyProgram,effec-tiveNovember20th.ShewillbelocatedinourNortherndivision,workingwithArielMarcoeontheupcomingCepheidRSV/FlutrialinMinocqua.JordynisarecentgraduateofUW-LaCrosse,withabachelordegreeinCommunityHealthEducation/PublicHealth.ShehasbeenworkingwithCCEPHsinceJune2017ontheSophiaLymestudy.Thisex-periencewillserveherwellasshetransitionstotheClinicalResearchprogram. 

Gail Weinand  

GailWeinandhasacceptedatemporaryRCApositionwiththeClinicalResearchCenter–Multi-specialtyProgram,effectiveDecember4th.ShewillbelocatedinourNortherndivision,workingwithArielMarcoeandJordynFinkontheupcomingCepheidRSV/FlutrialinMinocqua.GailwasaCerti-iedOccupationalTherapistforalmost15years.Mostrecently,shehasbeenworkingwithCCEPHsinceJune2017ontheSophiaLymestudy.Thisexperiencewillserveherwellasshetransitionstoourprogram.

Daniel Wall  

DanielWalljoinedOncologyResearchonDecember17thintheroleofOncologyResearchAdministrator.DanielhasbeenanintegralpartoftheMCRIleadershipandhassupportedBIRCtre-mendously.Hehasbeenwiththeorganizationfor5.5years(1.5yearsasanAssociateCenterAdmin-istratorinBIRC).Danielhasadeeppassionforpa-tientcareandclinicalresearchandhasservedonseveralregionalandnationalcommitteessuchas:NorthAmericanPrimaryCareResearchGroup

(NAPCRG);AdvisoryPanelMember,Assessment,Prevention,DiagnosisandTreatmentOption,PCORI;PatientRepresentative,GastrointestinalDrugsAdvisoryCommittee,FDA;andWisconsinResearchandEducationNetwork(WREN).

Dr.JefferyVanWormer,ResearchScientistfromCenterforClinicalEpidemiologyandPopulationHealth(CCEPH)hasbeennamedInterimCenterDirectorforCenterforOralandSystemicHealth(COSH)effectiveDecember11,2017.

Dr.VanWormerhasbeenaJointAppointeeScientistwithCOSH(SecondaryAppointment)thelastthreeyearsandhasleadtheDentalPublicHealthcore.Hehassuccessfullymentoredseveralsummerinterns/juniorscientistswithinCOSHandworkedonmanydentalandcraniofacialresearchprojects.HeisthePrincipalInvestigatoronarecentlyfunded,internal

researchgranttoassesstheoralhealthliteracyamongthedentalpatientsservedbyourhealthsystem.Hehaspublishedseveralmanuscriptsinthedentalpublichealthdiscipline.

WewanttowishDr.VanWormertheverybestinthisnewrole.HewillcontinuetoserveastheResearchScientistatCCEPHwherehisprimaryappointmentresides.

COSH Welcomes New Interim Center Director 

MCRI is currently recrui ng for 

several posi ons. Many are  

eligible for an ERP bonus if your  

referred candidate is selected.  

Applicants should visit HR’s Career 

Opportuni es webpage to apply. 

Susan Franseen 

SusanFranseenjoinedtheOf iceofResearchComplianceasaProjectManageronJanuary29th.Susanbringsexcellentexperienceworkingwithclinicaltrials,pharmacyandregulatoryaffairsfromhertimewithOncologyResearch.Weknowyouwillallenjoyinteractingwithherasweworkthroughthegoalsofthenew2018-2019ResearchComplianceWorkPlan.

Research Support Services TheOf iceofResearchSupportServices(ORSS)providesassistancetothoseengagedinresearchatMCRIbyfacili-tatingproposaldevelopment,grantandcontractsubmission,andmanuscriptwriting/editing.Additionally,thesup-portteamhelpsresearchersmaintaincompliancewiththeregulatoryrequirementsofhumanresearchprotectionsaswellasdataandmaterialtransfers.TheORSSteamperiodicallysharestipsandguidancetofurthertheknowledgeofallourresearchstaff.Inthisissue,Scienti icResearchWriterEmilyAndreae,PhDdiscussestipstokeepinmindwhenwritingcasereports,IRBAdministratorLoriSchellersharesupdatesonMCRI’shumanresearchprotectionprogram,andtheOf icewelcomesitsnewDirector.

Implementa on of Final Version for the ‘Common Rule’ Policy Delayed 

OnJanuary17,2018–HHSand15OtherFederalDe-partmentsandAgenciesAnnouncedanInterimFinalRulethatdelaysboththeeffectivedateandgeneralcompliancedateoftherevisionstotheFederalPolicyfortheProtectionsofHumansSubjectsuntilJuly19,2018.TherevisionsproposedintheFinalCommonRulewhichwaspublishedinJanuary2017togointoeffectonJan.19,2018,wereintendedtomodernize,strengthenandmakemoreeffectivetheFederalPoli-cyfortheProtectionofHumanSubjectsthatwasorig-inallypromulgatedasa“CommonRule”in1991.

AtthistimeallFederalregulationsinwhichMarsh-ieldClinicResearchInstitute’sIRBfollowswillremainastheyarecurrently.AswearegivenfurtherguidanceandareclosertotheJulydate,wewillplanforfurtherdiscussionsandtrainings.

IRB Policies, Procedures, Resource Guides and Forms AllIRBpolicies,procedures,resourceguidesandformshavebeenorareintheprocessofbeingrevisedduetoorganizationalnamechangesandtitlechanges.Someproceduresandresourceguideswithadditionalchangesinclude: Changes/AmendmentstoApprovedResearch–

addstherequirementtonotifytheIRBofadd/removalofKeyPersonnel.Thisisalsore lectedintheChange/Updateform

HumanitarianUseDevice–UpdatedHUD&HDEde initionsperthe21stCenturyCuresAct

InformedConsentofIlliterateorLegallyBlindParticipants–allowsforelectronictechnologytoassistlegallyblindparticipantsinreadingthein-formedconsent

ForthemostcurrentIRBpolicies,proceduresandre-sourceguidespleaseaccessthemintheDocumentControlSystem.ForthemostcurrentversionoftheIRBformspleaseaccesstheminthePolicy&Hand-bookLibrary–Formsdirectory.

ORSS Welcomes New Director

JordonOttassumedtheroleofORSSDirectoronFebruary19th.Nostrangertoourorganization,shewaswithMCRIinthepastwhereshehadservedinmultiplerolesasCenterManager(Marsh ieldEpidemiologyResearchCenter(MERC)nowCCEPHandBiomedicalInfor-maticsResearchCenter(BIRC)nowCCBI)aswellasCenterResearchAdministratorofMERC.

Mostrecently,JordanservedastheDirector,Of iceofExtramuralSupportatUniversityofWisconsin-Extension(UWEX)inMadisonsinceFebruary,2014.AtUWEX,Jordandirectedcentrallyorganizedadministrative,business,and inancialfunctionsrelatedtoawardadministrationforUWEXwithover$38millioninextra-muralfundsreceivedinFY2016.Shealsoassistedfaculty,academicstaffandtheiradministratorsintheidenti icationofresourcesforandthemanagementofindividualsponsoredprojectsconsistentbothwithUWEXmissionandwithintheobligationsofexternalsponsors.Jordanwasresponsibleforcompliancetofederal,stateandprivateregulationsaswellasoversawproposalpreparationandpostawardactivitiesforalargevolumeanddiversesetofcomplex,federallyandnon-federallysponsoredresearchprojects,involvingmultiplesub-awards,principalinvestigators,and/orcrosscampusinitiatives.

JordanearnedaBachelorofArtsdegreewithamajorinEnglishandaminorinBusinessandAccountingfromUniversityofMaryland,MD.JordanalsohasextendedleadershiptrainingfromAcademyofLeadershipandInnovation(UWEX),UniversityofSt.ThomasandLeadershipMarsh ield.Sheisamemberofnumerousprofessionalorganizations,includingNationalCouncilofUniversityResearchAdministrators,NationalGrantsManagementAssociation,andSocietyforResearchAdministrators.

Research Support Services 

Casereportsandcaseseriesareawayforcliniciansandclinicalresearcherstodisseminateknowledgetothewidermedicalcommunity.Thesedocumentshighlightimportantfeaturesofacase(s)toeducatecliniciansorenhancemedicalpractice[SunZ.,2013;Cohen,2006].Thoughformattingvariesamongjour-nals,casereportsarewrittenwithoneormoreofthefollowinggoalsinmind[SunZ.,2013;Cohen,2006]: Describethecourseofararedisease.

Highlightnovelfeaturesofadisease,setofdiseases,orclinicalresponsetotreatment.

Describeanoveltreatmentregimen.

Providebestpracticerecommendationsforclinicalprocesses.

Well-writtencasereportsarestructuredwithaclearfocusandprovideenoughinformationofthefeaturedcondition,treatment,orprocesstoenhanceunder-standingbyoutsideclinicianswhoareunfamiliarwiththecase.Thefollowingtipscanhelpyousuc-cessfullywriteandeditcasereports.

PerformaninitialPubMedorOvidliteraturesearch.Familiarizingyourselfwiththemedicallitera-tureassociatedwithyourcase(s)ofinterestpriortowritingwillhelpyouassess,develop,andre ineyourreport.Oftentimes,acasereportwillberejectedsimplybecauseitdoesnotenhancetheliteratureoroutlinesacommoncondition.

Gatherallnecessarypatientinformationforthereportbeforeyouwrite.Yourconclusionsregardingaparticularcase(s)arelargelybasedonthestrengthandcompletenessoftheprovidedclinicalinfor-mation.Addingadditionaltreatmentregimens,inter-ventions,orrelevantco-morbidconditionstoacasereportcancompletelyalteryourconclusionsandre-quirerevisionsthroughoutthemanuscript.

An Introduc on to Case Reports  

Receivepermissiontopublishidentifyingpatientinformation.Casereportsthatincludefacialpicturesorotherpotentiallyidentifyingpatientinformationrequirepermissionfrompatientsortheirauthorizedrepresentativespriortosubmission.Ifyouareunsureifconsentisrequired,contactyourdepartment’scomplianceof icer.

Avoidusingtermsassociatedwithresearchlike“hypothesis,”“study,”or“results.”Casereportsandcaseseriesaredescriptiveinnatureandarenotcon-sideredresearch.Thatbeingsaid,casereportsareausefulsourceofinformationfordevelopinghypothe-sesandfutureresearchefforts.

Foradditionalinformation,pleasereviewthefollow-ingsources:

Anwar,R.HowtoWriteaCaseReport.StudentBMJ.2004Feb(12).Accessed12Dec2017.

http://www.institutodeinvestigaciones.org/docs/write_case_report.pdf

SunZ.Tipsforwritingacasereportforthenoviceauthor.JMedRadiatSci.2013Sep;60(3):108-13.

CohenH.Howtowriteapatientcasereport.AmJHealthSystPharm.2006Oct1;63(19):1888-92.

References:Tipsforwritingacasereportforthenoviceauthor.JMedRadiatSci.2013Sep;60(3):108-13.

CohenH.Howtowriteapatientcasereport.AmJHealthSystPharm.2006Oct1;63(19):1888-92.

Publica ons 

TheDecember8,2017issueoftheJMIRMedicalInformaticsjournal,atop-rated,tierAjournalwhichfocusesonclin-icalinformaticsandbigdataanalyticsinhealthcare,includedanoriginalresearchpaperentitled“AdverseDrugEventsDiscoveryUsingBiomedicalLiterature:ABigDataNeuralNetworkAdventure”.

Dr.AhmadP.Tafti,JonathanBadger,EricLaRose,EhsanShirzadi(IEEE),Dr.JohnMayer,AndreaMahnke,Dr.ZhanYe,Dr.DavidPage(UW-Madison),andDr.PeggyPeissigconceivedanddesignedthestudy,andcollaboratedonthepaperwhichaimsatdevelopinganintelligentbigdataarti icialneuralnetworkframeworkcomposedofElas-ticsearchNo-SQLdistributedDatabaseandApacheSparktoextractadversedrugeventsemployingamassiveda-tasetobtainedfromPubMedCentralandhealth-relatedsocialmedia(e.g.,WebMD,MedHelp,Patient).

Theaccuracy,precision,recall,andareaunderreceiveroperatingcharacteristicofthesystemwere92.7%,93.6%,93.0%,and0.905,respectively,andshowedbetterresultsincomparisonwithtraditionalapproachesinthelitera-ture.Thisworknotonlydetectedandclassi iedADEsfrombigdatabiomedicalliteraturebutalsoscienti icallyvisu-alizedADEinteractions.

Dr.JosephMazzahasreachedakeymilestonewithpublishingresearchstudiesinhis47yearsofserviceatMarsh ieldClinicasahematologist/oncologist.WithhiscontinuedinvolvementinresearchasanEmeritusResearcherattheMarsh ieldClinicRe-searchInstitute(MCRI),Dr.Mazzahasnowpublishedmorethan150peer-reviewedscienti icmanuscriptsinvariousnationalandinternationaljournals.Hiswritingalsoincludesthreebooks,oneofwhichhasthreeeditionsand10chaptersofsci-enti icliterature.

“Wearesofortunatetohavesuchahighcaliberclinicalsci-entistofDr.Mazza’sexpertiseandreputationatMCRI,”saidDr.AmitAcharya,executivedi-rectorofMCRI.“ItisaproudmomentforallofustocelebrateDr.Mazza’ssigni icantpublica-tionmilestone.ThisshowsthedepthandbreadthofDr.Mazza’sresearchandhiscollaboration.”

Dr.MazzajoinedtheClinicin1970aftera ive-yearfellowshipprograminhematologyandinternal

medicineatMayoClinic.Hehasservedastheassis-tantdirectoroftheinternalmedicineresidencypro-gram,anddirectorofthemedicine/pediatricpro-gram.In1992,hebecamedirectorofmedicaleduca-tion.Priortothismilestone,Dr.Mazzawastherecip-ientoffourteachingawards.Currentlyhecontinuestoteachintheresidencyprogramsandmentorthoseinterestedinclinicalresearch.

“Dr.JoeMazzarepresentsthepassionforexcellenceinmedi-cineandloveofscience,”saidDr.RobertHaws,directorofclinicalresearch.“Hispublica-tionsrepresentthousandsofhoursofresearchthathavechangedandimprovedmedicalcareforthoseaffectedbycancerandotherblooddisorders.Un-doubtedly,hisresearchhassavedlivesandimprovedthe

qualityoflifeformany.HehasbeenthementorforhundredsofdoctorsthatcurrentlyareleadersattheMarsh ieldClinicandthroughouttheworld.Hisim-pactonmedicineandonpeopleisamazing.”

Dr. Joseph Mazza hits key research publica on milestone

CCBI Big Data Adverse Drug Events Analysis Published in JMIR Medical Informa cs  

Recent Publica ons and Grants 

Eachmonth,MCRIresearchersandMCclinicalinvestigatorsareactivepublishingjournalarticlesandseekingre-searchfunding.AlistingofpublicationsispostedmonthlyontheMCRIwebsite.Herearethegrantsreceivedsinceourlastpublication.

Presenta ons 

COSH Presents at the AMIA 2017 Annual Symposium in Washington D.C.  

Mr.HarshadHegde,InformaticsResearchArchitect,presentedaposterentitled,“QualityImprovementDashboardtoMonitorOralManifestationsofDysglycemicPatients,”attheAmericanMedicalInformaticsAssociation(AMIA)2017AnnualSymposiuminWash-ingtonD.C.,November4–8,2017.Alsoinattendance,representingCOSH,wasDr.NeelShimpi,AssociateResearchScientistandMr.AlokPanny,ResearchSpecialist.AMIAistheprofessionalhomeofleadinginformaticians:clinicians,|scientists,researchers,educa-tors,students,andotherinformaticsprofessionalswhorelyonda-tatoconnectpeople,information,andtechnology.AMIA®(theAmericanMedicalInformaticsAssociation®)isthecenterofactionformorethan5,000healthcareprofessionals,informaticsre-searchers,andpioneersinbiomedicine,healthcareandscience.AMIAisanunbiased,authoritativesourcewithintheinformaticscommunityandthehealthcareindustry.AMIAanditsmembersaretransforminghealthcarethroughtrustedscience,education,andpracticeinbiomedicalandhealthinformatics.

Dr. Neel Shimpi, Mr. Harshad Hegde and Mr. Alok Panny at AMIA. 

Cer fica ons 

MollyDowden,ProjectManagerfortheClinicalResearchCenter(CRC),recentlyreceivedherProjectManagementProfession-al(PMP)certi icationfromtheProjectManagementInstitute(PMI).Thiscerti icationisrecog-nizedglobally,andisthemost

importantindustry-recognizedcerti icationforprojectmanagers.Withthiscerti ication,Mollywillbeabletoputherprojectmanagementtheoriesandpracticalapplicationstogooduseinmakingmeaningfulimprove-mentstotheCRCprogram.

KristinaFletty,ResearchCoordi-natorAssociatefortheClinicalRe-searchCenter(CRC),recentlyreceivedherClinicalResearchCoordinatorCerti ication(CCRC)fromTheAssociationofClinicalResearchProfessionals(ACRP).Thiscerti icationisthe

formalrecognitionofclinicalresearchprofessionalswhohavedemonstratedtheknowledge,skills,andabilitiestoperformethicalandresponsibleclinicalresearchbypassinganexambasedoninternationalstandards.KristinaiscurrentlyworkingwithDr.BobHawsonseveralprojectsthatstudypatientswithararegeneticdisorder,Bardet-BiedlSyndrome(BBS).

Community & Volunteerism 

TheHolidayseasonisatimeofgivingandtheCenterforClinicalEpidemiologyandPopulationHealth(CCEPH)didjustthat.Theygatheredtogetherforcol-lectionofnonperishablefooditems,cashdonations,andsocksinsupportofSouporSocks(SOS).SOSisaUnitedWayProgramandanemergencyfoodpantyforMarsh ieldandthesurroundingarea.

CCEPHdeveloped iveteamsandcreatedacheerfulenvironmentfulloffunandcompetitionwithastonish-ingresults.WiththelistofneededitemsproducedbySOS,CCEPHimplementedaweightandpointbasedcompetitiontoencouragedonations.Inamatteroftwoandahalfweeks,CCEPHcollected359itemsand$750incashdonationsforSOS.WitheverycompetitionthereisawinnerandthewinningteamwasTheUnper‐ishableElves.TeammembersincludedBobbiBradley,TaraJohnson,DianeKohnhorst,DavidMcClure,DebMulterer,JeremyPomeroy,andJeffVanWormer.

OursincereappreciationtoeveryonethatcontributedandtoCCEPHformakingadifferenceinourlocalcommunity.SpecialthankstoAngelaHarlessandKateLassafororganizingtheinitiative.

CCEPH Holiday Giving 

 

MACF Expresses Thanks for Coat Drive Contribu on 

Upcoming Talks and Presenta ons 

Grand Rounds (12:15‐1:00 p.m. in the Froehlke Auditorium)

Friday,March30thExternalCounterPulsationandYourHeart ShereifRezkalla,MD,FACP,FACC,FSCCT,Cardiology,Marsh ieldClinicHealthSystem 

ORCA Office Hours Lunch and Learn Sessions 

InMarch,theORCATeamintroducedanewseriesofLunchandLearnSessionsaddressingnewandexistingtechnologies,hardwareandsoftwareavailabletoMCRIandotherstaffinterestedinthetopics.The irsttopicwastitled“HowtoSubmitaGoodDataRequest”.ManystaffrequestinformationfromourDataWarehouseandtherearesomeBestPracticeswewouldliketosharetohelppromoteef icientful illmentofyourdataneeds.Otherfuturepresentationswillinclude“TechnologyReviewProcesses”,“TimeandEffortTipsandTricks”,“MCRIRequestMod-ule”and“MCRIHUBSecurityandNoti ications”.Wearealsoexcitedtohearfromyouontopicsthatwemaybringadditioninformationtoyouthruothermethods.PleasefeelfreetocontactJoeEllefsonorLaurelVerhagenwithanytopicsorsuggestedpresentations.Allsessionsheld12:00-12:30p.m.inLairdML2Aconferenceroom

Thursday,April12thMCISProcessReview(Resource,Security,Software,Hardware,etc.)

Wednesday,May9thTimeandEffortTipsandTricks

UW‐ICTR to Offer Short Course on Stakeholder Engagement Theshortcourse“EngagingKeyPartnerstoDesignandConductHighQualityClinicalResearch”willbeofferedbyourICTRpartnersatUW-MadisonthisJune.Learnmoreaboutthe1.5dayshortcourseanditsfocusonmethodsofstakeholderengagementcriticaltothesuccessofclinicalresearch.Throughdidacticandexperientiallearningactivi-ties,attendeeswillgainskillstoengagestakeholders(e.g.,patients,communitymembers,industry,clinicalsites,pay-ers,andgovernmentagencies).Uponcompletionofthisshortcourse,attendeescanexpecttoenhancethesuccessoftheirresearchproposals,easetheexecutionofstudies,andbebetterpositionedtogenerate indingsthatcanhaverealworldimpact.WhoShouldAttendDesigned for investigators, or research team members (including graduate students) who have received, or arethinkingaboutapplyingfor,researchgrantsinvolvingstakeholderengagement.Cost:$50registrationfeeperpersonor$100forresearchteamsupto4Dates:Tuesday,June5,12-4PM-Wednesday,June6,8AM-4:30PMLocation:HealthSciencesLearningCenter,750HighlandAve.,Madison,WI53792R N orcontactThuyDanTranwithanyquestions.

In Addi on: ThenextMCRIFullStaffmeetingisscheduledforMay24,2018at10:00AMintheFroehlkeAuditorium.QuestionscanberoutedoremailedtoMichelleWellsandtat1R3orwellsandt.michelle@marsh ieldresearch.org.

ForthelatestUW-ICTRnews,pleasevisit:https://ictr.wisc.edu/news/.

TheMarsh ieldClinicResearchInstitutewebsitecanbefoundatmarsh ieldresearch.org.

ArchivedissuesofResearchMattersareavailableonline.

Contributorstothisissue:Dr.AmitAcharya,Dr.EmilyAndreae,PattiBaer,BobbiBradley,YvonneCerne,MollyDowden,JoeEllefson,DebHansen,H.JakeHowey,LindaJaros,JeffreyJoyce,StephanieKarl,LauraLauer,DixieSchroeder,LoriScheller,MelissaSlager,Dr.AhmadPahlavanTafti,MichelleWellsandt. 

Editedby:PattiBaer,baer.patricia@marsh ieldresearch.org(ext.1-8840).

Great Minds Think Alike! 

ThefolksinFiscalrecentlytookteambuildingtothenextlevelbyunintentionallyexperienc-ingaDress-Like-A-ColleagueDay.TheThreeJ’s(JasonKing,JohnWelter,andJustinJordan)surprisedtheircoworkers-andthemselves–byappearingintheof icewearingnearlyidenticalout its.Asifwedon’thaveahardenoughtimekeepingtheJ’sstraightaroundhere,guys!Maybeinthefuturetexteachothertoschedulewhatnottowear.

Time Out for Fun