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Prevalence and Etiology of the Non-Medical Use of Prescription Medications
among College Students
Amelia M. Arria, Ph.D.Associate Professor
Department of Behavioral and Community HealthDirector, Center on Young Adult Health and Development
University of Maryland School of Public Health
For more information, email: [email protected]
Funded by NIH/NIDA R01-DA014845
Illinois Higher Education Center for Alcohol, Other Drug and Violence Prevention
Eastern Illinois UniversityApril 4, 2017
Overview
1. National Estimates of Prevalence
2. Background on the College Life Study
3. What we know
4. What we suspect
5. What we can do
National Estimates of Prevalence
9.2 9.28.8
8.38.6
8.17.7 7.7
7.47.0
6.6
5.86.2
7.6 7.77.4
6.97.2
6.76.5 6.6
6.35.9
5.3
4.6 4.7
2.72.3
2.0
2.0 2.2
1.6 1.51.4 1.3
1.21.3 1.1
1.5
0.60.5 0.5 0.5 0.4 0.4 0.5 0.5 0.5 0.3 0.3 0.3 0.5
2.3 2.32.1
2.0 1.9
2.0 1.9 1.9 1.9 1.9 1.81.4
1.7
0.0
1.0
2.0
3.0
4.0
5.0
6.0
7.0
8.0
9.0
10.0
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
%Past-Year Nonmedical Use of Prescription Drugs among 12- to
17-year-olds, 2002-2014 (SAMHSA, 2015)
Any Psychotherapeutics Pain Relievers Stimulants Sedatives Tranquilizers
14.4 14.614.9 15.1
15.7
15.0 14.9 15.1
14.3
12.7
13.7
12.211.8
11.412.0 11.9
12.4 12.512.2 12.0 12.0
11.1
9.810.1
8.8
7.8
4.0 3.8 4.0 3.84.2
3.5 3.43.7 3.6
3.1
3.9 3.7 3.9
0.5 0.5 0.5 0.6 0.6 0.6 0.5 0.5 0.5 0.4 0.3 0.4 0.4
4.95.3 5.2
5.5 5.55.2 5.4 5.4 5.3
4.55.0
4.54.1
0.0
2.0
4.0
6.0
8.0
10.0
12.0
14.0
16.0
2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014
%Past-Year Nonmedical Use of Prescription Drugs among 18- to
25-year-olds, 2002-2014 (SAMHSA, 2015)Any Psychotherapeutics Pain Relievers Stimulants Sedatives Tranquilizers
4.3
2.3
1.5
1.0
0.1
4.7
3.3
1.0
1.4
0.2
0.0
1.0
2.0
3.0
4.0
5.0
Any Psychotherapeutics Pain Relievers Stimulants Tranquilizers Sedatives
%Prescription stimulants are the only class of prescription drugs that are
nonmedically used more by full-time college students than part-time college and non-college peers (during the past month; ages 18-22; SAMHSA, 2015)
Full-time college students
Part-time college studentsand non-college peers
6.1
5.1
1.21.4
0.2
7.1
5.6
1.5
2.2
0.4
0.0
1.0
2.0
3.0
4.0
5.0
6.0
7.0
8.0
Any Psychotherapeutics Pain Relievers Stimulants Tranquilizers Sedatives
%Past-Year Nonmedical Use of Prescription Drugs,
among 12- to 17-year-olds, by Gender (SAMHSA, 2013)
Males Females
Post CollegeYear 4
24 Months:Interview
(n=1,101) 88%Screening(n=3,401)
12 Months:Interview
(n=1,142) 91%
36 Months:Interview
(n=1,097) 88%
48 Months:Interview
(n=1,019) 81%
60 Months:Interview
(n=1,001) 80%
Post CollegeYear 3
84 Months:Interview
(n=951) 76%
Post CollegeYear 2
Post CollegeYear 1
SeniorYear
JuniorYear
SophomoreYear
FirstYear
Summer Orientation
Baseline Interview(n=1,253)
72 Months:Interview
(n=982) 78%
Data weighted to adjust for both sampling bias and attrition. Source: College Life Study. Not to be shown or redistributed without written permission from Amelia M. Arria, PI
Weighted lifetime prevalence of drug use in thefirst four years of college, by year
0.0
10.0
20.0
30.0
40.0
50.0
60.0
70.0
Marijuana PrescriptionAnalgesics
PrescriptionStimulants
Hallucinogens Inhalants PrescriptionTranquilizers
Ecstasy Amphetamines Cocaine Heroin
Wei
ghte
d pe
rcen
t of s
tude
nts w
ho u
sed
drug
at l
east
onc
e in
life
tim
e
63%
23%
30%
16%
13%
7%
3%
13%
1%
8%
Year 4
Pre-College
Year 3
Year 2
Year 1
0.0
2.0
4.0
6.0
8.0
10.0
12.0
14.0
16.0
2003 2005 2007 2009 2011 2013
Estim
ated
% w
ith P
ast-
Year
Use
Year
Figure 1. Trends in past-year nonmedical use of prescription medications: 2003-2013
Sleeping MedsSedativesStimulantsOpioidsAny Meds
McCabe, S. E., West, B. T., Teter, C. J., & Boyd, C. J. (2014). Trends in Medical Use, Diversion, and Nonmedical Use of Prescription Medications among College Students from 2003 to 2013: Connecting the Dots. Addictive Behaviors, 39(7), 1176-1182.
What We Know
• Different drug classes = different harms• Definition of nonmedical use• Motives• Research Studies of College Students• Sources of obtaining drugs for nonmedical use• Access and availability
What We Know, continued
• Diversion is prevalent and fuels nonmedical use• Overestimation of others use• Positive and Negative Expectancies• High-risk Groups for use and diversion• Strong association with other drug use
Motives
• Curiosity
• Improve concentration
• Stay awake longer to study
• Stay awake longer to party, drink more
• Get high
• Relieve depression symptoms?
But remember, motives are not the same as risk factors
How often do users take prescription stimulants nonmedically?
11.3
15.313.8
0
5
10
15
20
25
30
Year 2 Year 3 Year 4
Aver
age
num
ber o
f tim
esin
the
past
yea
r
Source: College Life Study. Not to be shown or redistributed without written permission from Amelia M. Arria, P
What about students with ADHD who have their own prescribed ADHD medications?
Sources:Arria, A.M., Caldeira, K.M., O’Grady, K.E., Vincent, K.B., Johnson, E.P., Wish, E.D. (2008). Nonmedical use of prescription stimulants among
college students: Associations with attention-deficit-hyperactivity disorder and polydrug use. Pharmacotherapy, 28(2) 156-169.Wilens, T.E., Gignac, M., Swezey, A., Monuteaux, M.C., Biederman, J. (2006). Characteristics of adolescents and young adults with ADHD who
divert or misuse their prescribed medications. J Am Acad Child Adolesc Psychiatry, 45(4), 408-14.
• 27% overused their own meds• 16% nonmedically used someone else’s ADHD meds
Among 45 first-year college students with ADHD:
• 22% misused or took too much of their meds• 10% got high on their meds• 8% grinding/sniffing• Nearly all of the misusers (83%) met criteria for CD and/or SUD,
and all were using immediate-release formulations.
In another sample of 55 males (mean age 21) with ADHD:
Sources
Among college students, friends and peersare the most common sources to obtain prescription medications used nonmedically
References: McCabe SE, Teter CJ, Boyd CJ. Medical use, illicit use and diversion of prescription stimulant medication. J Psychoactive Drugs 2006;38(1):43-56. McCabe
SE, Boyd CJ. Sources of prescription drugs for illicit use. Addict Behav 2005;30(7):1342-1350. McCabe SE, Cranford JA, Boyd CJ, Teter CJ. Motives, diversion and routes of administration associated with nonmedical use of prescription opioids. Addict
Behav 2007;32(3):562-575. Barrett SP, Darredeau C, Bordy LE, Pihl RO. Characteristics of methylphenidate misuse in a university student sample. Can J Psychiatry 2005;50(8):457-
461.
How are ADHD meds obtained for nonmedical use?
0102030405060708090
Friend w/Rx
Friendw/o Rx
Other Self Internet $0 $1-4 $5+
Perc
ent o
f use
rs
Year 1 Year 2 Year 3 Year 4
*
Sources of Medication*Denotes significant difference from years 1 and 2 (p<.05).
Garnier-Dykstra, L.M., Caldeira, K.M., Vincent, K.B., O’Grady, K.E., Arria, A.M. (2012). Nonmedical use of prescription stimulants during college: Four-year trends in exposure opportunity, use, motives, and sources. Journal of American College Health, 60(3), 226-234.
Cost**Denotes significant difference from years 3 and 4 (p<.05).
**
DIVERSION60.2% of one sample of college students with ADHD shared or sold their prescription stimulants;
35.4% of students with prescription analgesics diverted their medications.
Source: Garnier, L.M., Arria, A.M., Caldeira, K.M., Vincent, K.B., O'Grady, K.E., Wish, E.D. (2010). Sharing and selling of prescription medications in a college student sample. Journal of Clinical Psychiatry. 71(3), 262-269.
Students overestimate how many others use
Source: Carroll, B. C., McLaughlin, T. J., & Blake, D. R. (2006). Patterns and knowledge of nonmedical use of stimulants among college students. Archives of Pediatrics and Adolescent Medicine, 160(5), 481-485.
Students who reported their peers used stimulants
nonmedically
Students who used stimulants nonmedically
High levels of positive
expectancies about the
purported benefit on performance
“It will work”
Low levels of negative
expectancies about the
purported benefit on performance
“I won’t get in trouble”
Nonmedical Use is also associated with:
Source: Bavarian N, Flay BR, Ketcham PL, Smit E, Illicit Use of Prescription Stimulants in a College Student Sample: A Theory-Guided Analysis. Drug and Alcohol Dependence 2013; 132:665-673.
High Risk Groups
• Students attending competitive colleges
• Students involved with Greek organizations
• High-risk drinkers and other drug users
• Students who are academically struggling
• Students who are not risk-aversive
• Students who have misperceptions of prevalence and what is normative
• Students who perceive drugs as benign, safe to use
Nonmedical prescription drug use is strongly associated with alcohol and other drug use
• Numerous studies report past-year prevalence estimates for marijuana use of 85%+
• Cocaine: 35-60%
• Ecstasy: 52%
• Prescription Analgesics: 44%
Nonmedical Use
Medically Supervised Use
Medical Overuse
RISK FOR ILLICIT
DRUG USE
RISK FOR ILLICIT
DRUG USE
RISK FOR ILLICIT
DRUG USE
NON-USERSof Rx Stimulants
(n=989)
NONMEDICAL USERSof Rx Stimulants
(n=217)Alcohol 93.5 % 100.0 %Tobacco Cigarettes 55.3 89.4Marijuana 62.8 93.5Hallucinogens 7.0 41.5Cocaine 2.8 18.0Inhalants 4.8 15.7Ecstasy 2.6 15.2Amphetamines 0.9 8.8Heroin 0.2 0.9Nonmedical use of prescription analgesics 10.1 44.2
Nonmedical use of prescription tranquilizers 3.7 20.7
Overlap between nonmedical prescription stimulant use and other drug use
What We Suspect
Marijuana and other drug use might be driving academic problems, and nonmedical use of prescription stimulants is a compensatory behavior… a shortcut, and largely unsuccessful.
Nonmedical stimulant users spend less time
studying, skip classes more often,
and earn lower grades.
Source: Arria AM, O'Grady KE, Caldeira KM, Vincent KB, Wish ED. (2008). Nonmedical use of prescription stimulants and analgesics: Associations with social and academic behaviors among college students. Journal of Drug Issues. 38(4), 1045-1060.
Nonmedical Use of Prescription Stimulants for Studying
Time
Marijuana Use
Skipping Class
Academic Performance
Marijuana Dependence
NPS use patterns from Year 2 to Year 3 of the College Life Study (n=898).
Abstainedfrom NPS
n=618
Persisted in NPSn=150
Desisted n=52Initiated
NPSn=78
0.016
-0.025
0.053
-0.025
-0.08
-0.06
-0.04
-0.02
0.00
0.02
0.04
0.06
0.08
Chan
ge in
GPA
Estimated marginal means and standard error bars for change in GPA during years 2-3, by NPS use pattern (n=898).
Desisted from NPS
n=52
Persisted in NPSn=150
Abstainedfrom NPS
n=618
Initiated NPSn=78
Note. Sample is restricted to individuals who were never diagnosed with ADHD by Year 3. Change in GPA is computed as the difference between Year 3 GPA and Year 2 GPA, which were averaged from semesters 3-4 and 5-6, respectively. Results are adjusted for the effects of sex and Year 2 GPA. Normal distribution was assumed for GPA change score. Zero values for semester GPA were treated as missing because they cannot be distinguished from missing data due to studying abroad.
Overall sample y=0.005
Source: Arria, A.M., et al., Do college students improve their grades by using prescription stimulants nonmedically?, Addictive Behaviors (2016), http://dx.doi.org/10.1016/j.addbeh.2016.07.016
Interpersonal factors are important influences on nonmedical use…
• Academic self-efficacy • Perception of risk • Perception of reward
Academic Self-Efficacy
• Definition: Having confidence about your ability to complete academic tasks
• Students who were less confident about their ability to avoid nonmedical prescription stimulant use when they had a large amount of work in a short amount of time were more likely to use (Bavarian, 2013).
• The more students procrastinate, the more likely they are to useprescription stimulants nonmedically. A possible solution: createa personalized study plan that outlines study times, learning goals (and class attendance) (Ponnet, 2015).
Academic Self-
Efficacy
Experiences
Practice(Ability)
Influences and Attitudes
of Others
Individuals with low academic self-efficacy might be at high risk for NPS use
Risk and Reward…1. Is it risky?
2. Is there a benefit to using?
3. Does the benefit outweigh the risk?
% u
sing
0
5
10
15
20
25
30
35
40
45
High Perceived Harm Low Perceived Harm
Stimulants Analgesics
Nonmedical use is higher among students who perceive lower levels of harm
Source: Arria AM, Caldeira KM, Vincent KB, O'Grady KE, Wish ED. (2008). Perceived harmfulness predicts nonmedical use of prescription drugs among college students: Interactions with sensation-seeking. Prevention Science. 9(3), 191-201.
Source: Arria AM, Caldeira KM, Vincent KB, O'Grady KE, Wish ED. (2008). Perceived harmfulness predicts nonmedical use of prescription drugs among college students: Interactions with sensation-seeking. Prevention Science. 9(3), 191-201.
However… among sensation-seekers, perceived harm did not influence analgesic use
What we can do
1. Improve physician education and vigilance
2. Intervene by discussing both risk and reward perceptions
3. Correct student misperceptions
4. Educate parents
5. Focus on more subtle consequences
6. Give non-using students a louder voice
1. Monitor medication and other drug use– Pill counts
– Frequent office visits
– Urine toxicology screens
2. Prescribe medications with lower abuse potential– Non-stimulants
– Extended-release preparations
3. Dose judiciously
4. Discuss compliance, “extra doses,” and treatment failure
Clinicians: Considerations for Treating ADHD in High-Risk Patients
Clinicians: Considerations for Treating ADHD in High-Risk Patients
5. Utilize regular dosing, not PRN6. Advocate for safe storage (don’t
advertise)7. Ask about changes in euphoria,
cravings8. Discuss ethical and legal issues
around diversion9. Support prescription drug
monitoring programs
Improving Clinical Practice on College Campuses
Increase vigilance regarding diversion and nonmedical use among college-bound patients.
Partner with local university health centers to promote staff awareness of diversion and the risks of
nonmedical use.
Work with counseling center staff to recognize signs of mental
health issues and drug problems… and intervene with students who are academically
struggling.
Screen ADHD patients for illicit drug use and convey
risks of diversion.
Students
Spread the word to other students about the true risks of nonmedical use and connection to marijuana use.
Challenge misperceptions about “how many people are doing it.”
Link nonmedical drug use to illicit drug use.
Dispel “smart drug” myth.
THC concentrations have increased dramatically from 1995 to 2014
3.96
11.84
0.00
2.00
4.00
6.00
8.00
10.00
12.00
14.00
1995
1996
1997
1998
1999
2000
2001
2002
2003
2004
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
CBD THC
ElSohly, M. A., Mehmedic, Z., Foster, S., Gon, C., Chandra, S., & Church, J. C. (2016). Changes in cannabis potency over the last 2 decades (1995-2014): Analysis of current data in the United States. Biological Psychiatry, 79(7), 613-619.
International concern exists regarding high-potency cannabis,
especially because of the implications for mental health
Students on Medication
Adhere to your provider’s medication instructions.
Never share your medication… not with anyone.
Protect your medication from theft.
Encourage responsible help seeking.
Convey messages about risks of nonmedical use.
Parents
Dispel “smart drug” myths. Do not condone or facilitate nonmedical use. Empower parents to take a central role in preventing
nonmedical use of prescription drugs. Raise awareness about the opportunities for “new” drug
use in college. Educate parents to recognize signs of emerging mental
health and drug problems. Educate parents regarding medication adherence and
role modeling of proper use Parent effectively to reduce risk of use
Colleges and Universities Sponsor ongoing dialogues that raise awareness and
share experiences of college professionals
Develop multidisciplinary campus action plans to reduce nonmedical prescription stimulant use.
Have students re-think taking 18 credits per semester in the first year of college.
Consider options for enforcing sanctions against diversion.
Give students who don’t use a LOUDER voice
Monitoring the Future, not published.
Cognitively Strong
Interlocking Dimensions of Student Success
For more information and a list of publications, please visit:
www.cls.umd.edu
www.cyahd.umd.edu
Thank you!
Email Dr. Arria at [email protected]
