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Presented By:
Julie Hoffman, ADN, RN, OCNSylvia Wentzky, ADN, RN
Bon Secours St. Francis Health System Greenville, South Carolina
The purpose of this Evidence Based Project was to compare the cost effectiveness of two anti-nausea medications: ALOXI and ZOFRAN for patients receiving highly emetogenic chemotherapy regimens, such as Cisplatin.
Bon Secours St. Francis Health System Outpatient Infusion Center
Retrospective 3 month chart review Solid tumor types 100 adult patients
Gender Age Diagnosis Types of Lung Cancer Treatments Antiemetics in Cisplatin Protocols
ALOXI- 8% Total Cost SavingsIncreased Patient SatisfactionDecreased Nursing Time
ZOFRAN-Lower Patient SatisfactionIncreased Clinic VisitsIncreased Nursing Time
Aloxi:IV push 1 dose day of chemoNursing time - 5 minutesSupplies – needle & syringe
Zofran:IVPB treatment day2 extra days of IV fluids and daily Zofran IVPBNursing time – 6.5 hoursSupplies – IV tubing
The cost analysis demonstrated that selecting Aloxi on Day 1 of the chemotherapy treatment impacted:
Cost Patient Satisfaction Nurse Time Limitations of this study included a small
sample size, retrospective nature, and selective diagnosis of Lung Cancer.
Product Availability Provider Changes & Preferences Protocol Changes
◦Dexamethasone 10 mg IVP◦Zofran 8 mg IVP◦Emend 150 mg IVPB
3 Month Retrospective Analysis (2014)◦12 Lung Cancer Patients – Cisplatin
Treatment◦1 Patient Needed Hydration
DeLeon, A. (2006, October). Palonosetron (Aloxi): A Second Generation 5HT3 Receptor Antagonist for Chemotherapy-Induced Nausea and Vomiting. Baylor University Medical Center Proceeding, 19(4),413-416. Retrieved from http:///www.medscapecom/viewarticle/512796
Feinberg, B.A., Gilmore, J., Haislip, S., Gondesen, T., Saleh, N., Lenz, W. (2009, February). Data-Driven Medical Decision-Making in Managing Chemotherapy-Induced Nausea and Vomiting, Community Oncology, 62-67. Retrieved from http://www.CommunityOncology.net
National Comprehensive Cancer Network. (2011). NCCN Clinical Practice Guilelines in Oncology (NCCN Guidelines) Antiemesis (Version 1.2012). Fort Washington, PA: Ettinger, David S., et al.
Tarricone, R., & Girolami, F. (2005). Economic Evaluation of a New Antiemetic Drug – Palonosetron Versus Ondansetron, Clinical Drug Investiation, 25 (9), 597-608 Retrieved from http://www.nci.nlm.nih.gov/pmc/articles/PMC1618755
Bon Secours St. Francis Health Bon Secours St. Francis Health SystemSystemOutpatient Infusion CenterOutpatient Infusion CenterGreenville, South CarolinaGreenville, South Carolina
JULIE HOFFMAN, ADN, RN, OCNJULIANA_HOFFMAN @BSHSI.ORG
SYLVIA WENTZKY, ADN, [email protected]
TRACY FASOLINO, PhD, FNP, [email protected]
