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8/7/2019 Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt
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8/7/2019 Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt
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INTRODUCTIONy DWARKESH PHARMACEUTICALS PRIVATE LIMITED
(DPPL) , AHMEDABAD
y LOCATION :- 4801/5, GIDC, Phase IV, Vatva ,Ahmedabad,382445
y Mfg. Lic. No:- G/1404
y Overall Area:- 1900 sq. m
y Built up area:- 2600 sq. m
8/7/2019 Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt
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ORGANISATIONCompany has its organization in the following sequence
y Director :- Mr. Rajesh R. Gupta
y Associate director :- Mr. Rajat Gupta
y Chief Manufacturing Chemist :- Mr. Rakesh G. Patel
y Chief Analysis chemist :- Mrs. Clara Joseph
Organization at section level
y Manager
ySenior Operator
y Helper
y Maintainer
y Security
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MANUFACTURING UNIT
TABLETING SECTION
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STEPS INVOLVED INPROCESSING OF TABLET
Raw Material
Testing of raw material
Issue of raw material
Sifting of raw material
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8/7/2019 Presentation on Training Performed at Dwarkesh Pharmaceuticals Pvt
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Compression into tablet
In process testing of tablet
Coating of tablets
Visual inspection of tablets
Stripping & packaging of tablets
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TABLET FORMULATION SECTION
IS DIVIDED FURTHER INTO:yW
eighing Section
y Mixing Section
y Granulation Section
y Drying Section
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y Compression Section
y
In-process QualityC
ontrol
y Coating Section
y Packaging Section
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Weighing Sectiony In the weighing section all the weighing is done
in accordance with the Master Formulation
record.yWeighing is done by :
y Electronic balance
y Physical balance
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Mixing Section� All the materials received
from Weighing Section are
passed through sieves or sifters and mixed using mass
mixers.
� From here the mixed mass issent to Granulating section.
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Granulating Sectiony Here granulation of the
material received from
the Mixing Section isdone using multi mill .
y Multi mill·s screen no.
varies from 0.5, 1, 1.5,2, 6 & 7 ( in increasing
order of mesh size).
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Drying Sectiony Granules prepared in
the Granulating Section
are dried in FluidizedBed Dryer .
y Over drying should be
prevented.
y
For e.g. Paracetamol-20%-30% optimum
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Compression Sectiony Rotary Punching
Machines are used for
fast production oftablets.
y 16 station-15,000
tabs/hr
y Upto 23 stations single
hopper
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y Punch shape
Deep face-: sugarcoated tablets
Flat face-:uncoated
tablets
Punch size Weight of tablet(mg)
9/32 180-200
10/32 210-230
12/32 340-360
16/32 600-650
Oval 700-750
D.S. 800-1100
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In-Process Quality Controly Parameters noted:
Weight
Disintegration time
Friability
Hardness
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y Type of coating:
Sugar coating - sugar solution
Film coating ² Iso propyl alcohol
Enteric coating-Iso propyl alcohol + Acetone
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Packaging Sectiony Two types of packing:
y Blister pack
y Strip pack
y Temperature of roles:
y Forming role :-160°-
140°
y Sealing role :-170° -
190 °
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THANK YOU